Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T48703 | Target Info | |||
| Target Name | Toll-like receptor 8 (TLR8) | ||||
| Synonyms |
UNQ249/PRO286; CD288 antigen; CD288
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|
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| Target Type | Clinical trial Target | ||||
| Gene Name | TLR8 | ||||
| Biochemical Class | Toll-like receptor | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 14 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
6-Amino-2-butoxy-9-(5-piperidin-4-ylpentyl)-7H-purin-8-one;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3398488
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| Activity |
EC50 = 57000 nM
|
[1] | |||
| Compound Name |
Chembl4284645
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL20760756; BDBM50467918
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|
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| Activity |
EC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Chembl4288029
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL20761875; BDBM50467910
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|
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| Activity |
EC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Chembl4278564
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL20761205; BDBM50467913
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| Activity |
EC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Chembl4290288
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL20760565; BDBM50467914
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| Activity |
EC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Chembl4286476
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL20761270; BDBM50467916
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| Activity |
EC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Chembl4277080
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL20761531; BDBM50467915
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|
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| Activity |
EC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Chembl4293700
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL20760937; BDBM50467912
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|
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| Activity |
EC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Chembl4283103
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL20761549; BDBM50467911
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|
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| Activity |
EC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Chembl4279629
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL20761372; BDBM50467917
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|
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| Activity |
EC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Chembl4276704
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL20760966; BDBM50467919
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|
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| Activity |
EC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Chembl4280136
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL20760850; BDBM50467920
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|
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| Activity |
EC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Chembl4285025
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL20760753; BDBM50467921
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|
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| Activity |
EC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
6-Amino-2-butoxy-9-(4-piperidin-4-ylbutyl)-7H-purin-8-one;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3398487
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|
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| Activity |
EC50 = 131000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 5 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Imiquimod
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|
Approved | Compound Info | ||
| Synonyms |
Aldara; Beselna; Zartra; Zyclara; Imiquimod acetate; R 837; S 26308; Aldara (TN); Aldara, Imiquimod; Beselna (TN); DZ-2636; Imiquimod [USAN:INN]; MTD-39; R-837; S-26308; TMX-101; Imiquimod (JAN/USAN/INN); 1-(2-Methylpropyl)-1H-imidazole[4,5-c]quinoline-4-amine; 1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine; 1-(2-methylpropyl)imidazo[4,5-c]quinolin-4-amine; 1-isobutyl-1H-imidazo(4,5-c)quinolin-4-amine; 1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine; 3M Brand of Imiquimod; 4-Amino-1-isobutyl-1H-imidazo(4,5-c)quinoline; 4-Amino-1-isobutyl-1H-imidazo[4,5-c]quinoline
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|
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| Activity |
EC50 > 270000 nM
|
[3] | |||
| Compound Name |
6-Amino-2-butoxy-9-(2-piperidin-4-ylethyl)-7H-purin-8-one;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3398485
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|
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| Activity |
EC50 = 231000 nM
|
[1] | |||
| Compound Name |
6-Amino-2-butoxy-9-(3-piperidin-4-ylpropyl)-7H-purin-8-one;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3398486
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|
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| Activity |
EC50 = 260000 nM
|
[1] | |||
| Compound Name |
4-Amino-alpha,alpha-dimethyl-1H-imidazo(4,5-c)quinoline-1-ethanol
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|
Investigative | Compound Info | ||
| Synonyms |
R 842; UNII-T8NPD94NTJ; T8NPD94NTJ; CHEMBL195276; 1-(4-aminoimidazo[4,5-c]quinolin-1-yl)-2-methylpropan-2-ol; 2-Hydroxy Imiquimod; 4-amino-alpha,alpha-dimethyl-1H-imidazo[4,5-c]quinoline-1-ethanol; R-842; SCHEMBL189202; CTK8G5878; DTXSID80150133; 4-Amino-alpha,alpha-dimethyl-1H-imidazo(4,5-c)quinolin-1-ethanol; BDBM50403024; DS-020086; 1H-Imidazo[4,5-c]quinoline-1-ethanol, 4-amino-; A-dimethyl-; 4-amino-1-(2-hydroxy-2-methylpropyl)-1H-imidazo[4,5-c]quinoline; 4-amino-alpha,alpha,-dimethyl-1H-imidazo[4,5-c]quinoline-1-ethanol; 4-amino-alpha,alphadimethyl-1H-imidazo [4,5-c]quinoline-1-ethanol; 1H-Imidazo(4,5-c)quinoline-1-ethanol, 4-amino-alpha,alpha-dimethyl-
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|
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| Activity |
EC50 > 270000 nM
|
[3] | |||
| Compound Name |
Methyl 4-amino-1-(2-hydroxy-2-methylpropyl)imidazo[4,5-c]quinoline-7-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2216759; SCHEMBL14758154; BDBM50403023
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|
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| Activity |
EC50 > 270000 nM
|
[3] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural requirements for TLR7-selective signaling by 9-(4-piperidinylalkyl)-8-oxoadenine derivatives. Bioorg Med Chem Lett. 2015 Mar 15;25(6):1318-23. | ||||
| REF 2 | NLRP3 Modulators for the Treatment of Autoinflammatory Disorders. ACS Med Chem Lett. 2018 Sep 19;9(10):965-966. | ||||
| REF 3 | Discovery of Imidazoquinolines with Toll-Like Receptor 7/8 Independent Cytokine Induction. ACS Med Chem Lett. 2012 Jun 14;3(6):501-504. | ||||
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