Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T49031 | Target Info | |||
| Target Name | Proteasome beta-5 (PS beta-5) | ||||
| Synonyms |
Proteasome subunit beta type-5; Proteasome subunit X; Proteasome subunit MB1; Proteasome epsilon chain; Proteasome chain 6; Multicatalytic endopeptidase complex epsilon chain; Macropain epsilon chain; MB1; LMPX
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| Target Type | Patented-recorded Target | ||||
| Gene Name | PSMB5 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 20 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Orlistat
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|
Approved | Compound Info | ||
| Synonyms |
orlistat; 96829-58-2; Tetrahydrolipstatin; Xenical; Alli; Orlipastat; (-)-Tetrahydrolipstatin; Orlipastatum; Orlipastatum [INN-Latin]; THLP; Ro-18-0647; UNII-95M8R751W8; C29H53NO5; Ro 18-0647/002; N-Formyl-L-leucine (1S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester; (2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-2-yl (2S)-2-formamido-4-methylpentanoate; Orlistat (Alli, Xenical); MLS002207022; [(2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-2-yl] (2S)-2-formamido-4-methylpentanoate; CHEMBL175247; Alli; GlaxoSmithKline brand of orlistat; Roche brand of orlistat; Alli (TN); Hoffmann-La Roche brand of orlistat; KS-1183; Orlistat [USAN:INN]; R-212; Xenical (TN); Orlistat (USAN/INN); Ro 18-0647/008; Alli, Xenical, Tetrahydrolipstatin, Orlistat; N-Formyl-L-leucine, ester with (3S,4S)-3-hexyl-4-((2S)-2-hydroxytridecyl)-2-oxetanone; L-Leucine, N-formyl-, (1S)-1-(((2S,3S)-3-hexyl-4-oxo-2-oxetanyl)methyl)dodecyl ester; L-Leucine,N-formyl-, (1S)-1-(((2S,3S)-3-hexyl-4-oxo-2-oxetanyl)methyl)dodecyl ester; 1-((3-hexyl-4-oxo-2-oxetanyl)methyl)dodecyl-2-formamido-4-methylvalerate; TETRAHYDROLIPSTATIN
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Cbz-Ile-Pro-Ala-LeuVSMe
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL207670; Cbz-Ile-Pro-Ala-LeuVSMe
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| Activity |
IC50 = 150000 nM
|
[2] | |||
| Compound Name |
N-[(S)-2-Azido-3-phenylpropanoyl]-L-Leu-L-Leu-[(1S,2E)-1-[4-(aminomethyl)benzyl]-3-(methylsulfonyl)allyl]NH2
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2326533; BDBM50426994; J3.584.815K
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| Activity |
IC50 = 50000 nM
|
[3] | |||
| Compound Name |
(2S)-N-[(E,2S)-1-[4-(Aminomethyl)phenyl]-4-methylsulfonylbut-3-en-2-yl]-2-[[(2S)-3-(4-aminophenyl)-2-[[(2S)-2-azido-3-phenylpropanoyl]amino]propanoyl]amino]-4-methylpentanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2326260; BDBM50426992
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
Chembl4212401
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Investigative | Compound Info | ||
| Synonyms |
BDBM50458012
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
(2S,3S)-N-[(2R)-1-(3,4-Dimethylanilino)-1-oxo-3-phenylpropan-2-yl]-3-methyl-2-[(3-nitrophenyl)carbamothioylamino]pentanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4085613; BDBM50234640
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
Methyl N'-[(2S,3S)-1-[[(2R)-1-(3,4-dimethylanilino)-1-oxo-3-phenylpropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]-N-(3-nitrophenyl)carbamimidothioate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4070680; BDBM50234637
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
(2S)-2-[[(2S)-3-[4-(Aminomethyl)phenyl]-2-[[(2S)-2-azido-3-phenylpropanoyl]amino]propanoyl]amino]-N-[(E,2S)-1-[4-(aminomethyl)phenyl]-4-methylsulfonylbut-3-en-2-yl]-4-methylpentanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2326261; BDBM50426996
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
(2S,3S)-2-[(4-Bromophenyl)carbamothioylamino]-N-[(2R)-1-(3-chloro-4-methylanilino)-1-oxo-3-phenylpropan-2-yl]-3-methylpentanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4064812; BDBM50234633
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
(2S)-N-[(E,2S)-1-[4-(Aminomethyl)phenyl]-4-methylsulfonylbut-3-en-2-yl]-2-[[(2S)-2-[[(2S)-2-azido-3-phenylpropanoyl]amino]-3-pyridin-4-ylpropanoyl]amino]-4-methylpentanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2326541; BDBM50426997
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
(2S,3S)-N-[(2R)-1-(3-Chloro-4-methylanilino)-1-oxo-3-phenylpropan-2-yl]-3-methyl-2-[(3-nitrophenyl)carbamothioylamino]pentanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4096708; BDBM50234632
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
Ac-hPhe-Leu-(D)-Ala-LeuVSMe
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL438442; BDBM50186701
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| Activity |
IC50 = 56000 nM
|
[2] | |||
| Compound Name |
Chembl4281070
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Investigative | Compound Info | ||
| Synonyms |
BDBM50464964
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| Activity |
IC50 = 64000 nM
|
[6] | |||
| Compound Name |
Chembl4130258
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Investigative | Compound Info | ||
| Synonyms |
BDBM50274009
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| Activity |
IC50 = 67000 nM
|
[7] | |||
| Compound Name |
Chembl4127928
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Investigative | Compound Info | ||
| Synonyms |
BDBM50274043
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| Activity |
IC50 = 69000 nM
|
[7] | |||
| Compound Name |
Chembl4130108
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Investigative | Compound Info | ||
| Synonyms |
BDBM50274046
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| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
1,1'-[(2-Phenyl-1-buten-1-ylidene)bis(4,1-phenyleneoxy-2,1-ethanediyl)]bis[hexahydro-1H-azepine]
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Investigative | Compound Info | ||
| Synonyms |
RID-F; CHEMBL3099618; BDBM50444909
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
Chembl4127967
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Investigative | Compound Info | ||
| Synonyms |
BDBM50274041
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| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
Chembl4129702
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Investigative | Compound Info | ||
| Synonyms |
BDBM50273999
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| Activity |
IC50 = 125000 nM
|
[7] | |||
| Compound Name |
Chembl4128074
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Investigative | Compound Info | ||
| Synonyms |
BDBM50274034
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| Activity |
IC50 = 140000 nM
|
[7] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 41 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Bortezomib
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Approved | Compound Info | ||
| Synonyms |
179324-69-7; Velcade; Bortezomib (PS-341); UNII-69G8BD63PP; N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE; MLN-341; [(1R)-3-methyl-1-[[(2S)-3-phenyl-2-(pyrazine-2-carbonylamino)propanoyl]amino]butyl]boronic acid; [(1R)-3-Methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic acid; CHEMBL325041; 69G8BD63PP; Boronic acid,; DPBA; PROSCRIPT BORONIC ACID; LPD 341; LPD-341; VELCADE (TN); Velcade (TN); Pyz-Phe-boroLeu; Bortezomib(JAN/USAN/INN); Velcade, MG-341, PS-341, Bortezomib; N-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-Nalpha-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide; Bortezomib (Proteasome inhibitor); Peptide boronate
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| Activity |
IC50 = 512861384 nM
|
[8] | |||
| Compound Name |
Benzyl N-[(2S)-1-[[(2S)-1-[[(1S)-1-cyano-3-methylbutyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]carbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL206525; BDBM50410897
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| Activity |
Ki > 450000 nM
|
[2] | |||
| Compound Name |
Tert-butyl N-[(2S)-4-methyl-1-[[(1R)-2-(4-methylphenyl)-1-[(1S,2S,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.02,6]decan-4-yl]ethyl]amino]-1-oxopentan-2-yl]carbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3792846; BDBM50163712
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| Activity |
IC50 = 2137962.09 nM
|
[8] | |||
| Compound Name |
Tert-butyl N-[(2S)-4-methyl-1-oxo-1-[[(1R)-2-phenyl-1-[(1S,2S,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.02,6]decan-4-yl]ethyl]amino]pentan-2-yl]carbamate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3793010; BDBM50163709
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| Activity |
IC50 = 8317637.71 nM
|
[8] | |||
| Compound Name |
Tert-butyl N-[(2S)-3-(4-hydroxyphenyl)-1-oxo-1-[[(1R)-2-phenyl-1-[(1S,2S,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.02,6]decan-4-yl]ethyl]amino]propan-2-yl]carbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3793665; BDBM50163706
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| Activity |
IC50 = 8709635.9 nM
|
[8] | |||
| Compound Name |
Tert-butyl N-[(2S)-4-methyl-1-oxo-1-[[(1R)-1-[(1S,2S,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.02,6]decan-4-yl]pentyl]amino]pentan-2-yl]carbamate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3793633; BDBM50163708
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| Activity |
IC50 = 20417379.45 nM
|
[8] | |||
| Compound Name |
Benzyl N-[(2S)-3-(1H-indol-3-yl)-1-[[(1R)-3-methyl-1-[(1S,2S,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.02,6]decan-4-yl]butyl]amino]-1-oxopropan-2-yl]carbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3794482; BDBM50163714
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| Activity |
IC50 = 24547089.16 nM
|
[8] | |||
| Compound Name |
N-[(2S)-3-Methyl-1-[[(1R)-3-methyl-1-[(1S,2S,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.02,6]decan-4-yl]butyl]amino]-1-oxobutan-2-yl]-1,2,3,4-tetrahydronaphthalene-1-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3792403; BDBM50163566
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| Activity |
IC50 = 25703957.83 nM
|
[8] | |||
| Compound Name |
N-[(2S)-3-Methyl-1-[[(1R)-3-methyl-1-[(1S,2S,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.02,6]decan-4-yl]butyl]amino]-1-oxopentan-2-yl]-1,2,3,4-tetrahydronaphthalene-1-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3794131; BDBM50163642
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|
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| Activity |
IC50 = 57543993.73 nM
|
[8] | |||
| Compound Name |
Tert-butyl N-[(2S)-3-(4-hydroxyphenyl)-1-[[(1R)-3-methyl-1-[(1S,2S,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.02,6]decan-4-yl]butyl]amino]-1-oxopropan-2-yl]carbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3793068; BDBM50163705
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| Activity |
IC50 = 61659500.19 nM
|
[8] | |||
| Compound Name |
N-[(2S)-4-Methyl-1-[[(1R)-3-methyl-1-[(1S,2S,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.02,6]decan-4-yl]butyl]amino]-1-oxopentan-2-yl]-1,2,3,4-tetrahydronaphthalene-1-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3792405; BDBM50163633
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|
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| Activity |
IC50 = 70794578.44 nM
|
[8] | |||
| Compound Name |
(2S)-2-Acetamido-3-phenyl-N-[(1R)-1-[(1S,2S,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.02,6]decan-4-yl]pentyl]propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3794303; BDBM50163702
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|
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| Activity |
IC50 = 117489755.5 nM
|
[8] | |||
| Compound Name |
N-[(2S)-1-[[(1R)-3-Methyl-1-[(1S,2S,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.02,6]decan-4-yl]butyl]amino]-3-naphthalen-2-yl-1-oxopropan-2-yl]-1,2,3,4-tetrahydronaphthalene-1-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1169561; BDBM50163653
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|
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| Activity |
IC50 = 131825673.9 nM
|
[8] | |||
| Compound Name |
N-[(2S)-3-Methyl-1-[[(1R)-3-methyl-1-[(1S,2S,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.02,6]decan-4-yl]butyl]amino]-1-oxobutan-2-yl]-5,6,7,8-tetrahydronaphthalene-1-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3793192; BDBM50163686
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|
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| Activity |
IC50 = 144543977.1 nM
|
[8] | |||
| Compound Name |
(1S)-N-[(2S)-1-[[(1R)-2-(4-Methylphenyl)-1-[(1S,2S,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.02,6]decan-4-yl]ethyl]amino]-1-oxo-3-phenylpropan-2-yl]-1,2,3,4-tetrahydronaphthalene-1-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3792587; BDBM50163563
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|
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| Activity |
IC50 = 147910838.8 nM
|
[8] | |||
| Compound Name |
(1S)-N-[(2S)-1-[[(1R)-3-Methyl-1-[(1S,2S,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.02,6]decan-4-yl]butyl]amino]-3-naphthalen-2-yl-1-oxopropan-2-yl]-1,2,3,4-tetrahydronaphthalene-1-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3792602; BDBM50163655
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|
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| Activity |
IC50 = 162181009.7 nM
|
[8] | |||
| Compound Name |
(1S)-N-[(2S)-1-Oxo-3-phenyl-1-[[(1R)-2-phenyl-1-[(1S,2S,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.02,6]decan-4-yl]ethyl]amino]propan-2-yl]-1,2,3,4-tetrahydronaphthalene-1-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3793876; BDBM50163562
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|
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| Activity |
IC50 = 190546071.8 nM
|
[8] | |||
| Compound Name |
(1R)-N-[(2S)-1-[[(1R)-3-Methyl-1-[(1S,2S,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.02,6]decan-4-yl]butyl]amino]-1-oxo-3-phenylpropan-2-yl]-1,2,3,4-tetrahydronaphthalene-1-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3792730; BDBM50163560
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|
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| Activity |
IC50 = 194984460 nM
|
[8] | |||
| Compound Name |
N-[(2S)-1-[[(1R)-2-(4-Methylphenyl)-1-[(1S,2S,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.02,6]decan-4-yl]ethyl]amino]-1-oxo-3-phenylpropan-2-yl]pyrazine-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3794440; BDBM50163556
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|
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| Activity |
IC50 = 208929613.1 nM
|
[8] | |||
| Compound Name |
[(1R)-2-(4-Fluorophenyl)-1-[[(2S)-3-phenyl-2-(pyrazine-2-carbonylamino)propanoyl]amino]ethyl]boronic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL499083; BDBM50163718
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|
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| Activity |
IC50 = 229086765.3 nM
|
[8] | |||
| Compound Name |
N-[(2S)-1-[[(1R)-3-Methyl-1-[(1S,2S,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.02,6]decan-4-yl]butyl]amino]-3-naphthalen-1-yl-1-oxopropan-2-yl]-1,2,3,4-tetrahydronaphthalene-1-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1169560; BDBM50163649
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|
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| Activity |
IC50 = 234422881.5 nM
|
[8] | |||
| Compound Name |
N-[(2S)-1-[[(1R)-3-Methyl-1-[(1S,2S,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.02,6]decan-4-yl]butyl]amino]-1-oxo-3-phenylpropan-2-yl]-1,2,3,4-tetrahydronaphthalene-1-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3793344; BDBM50163558
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|
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| Activity |
IC50 = 239883291.9 nM
|
[8] | |||
| Compound Name |
N-[(2S)-3-(1H-Indol-3-yl)-1-[[(1R)-3-methyl-1-[(1S,2S,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.02,6]decan-4-yl]butyl]amino]-1-oxopropan-2-yl]-1,2,3,4-tetrahydronaphthalene-1-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3794171; BDBM50163663
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|
||||
| Activity |
IC50 = 275422870.3 nM
|
[8] | |||
| Compound Name |
N-[(2S)-1-Oxo-3-phenyl-1-[[(1R)-2-phenyl-1-[(1S,2S,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.02,6]decan-4-yl]ethyl]amino]propan-2-yl]-1,2,3,4-tetrahydronaphthalene-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3793066; BDBM50163669
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|
||||
| Activity |
IC50 = 295120922.7 nM
|
[8] | |||
| Compound Name |
Benzyl N-[(2S)-3-(1H-indol-3-yl)-1-[[(1R)-2-(4-methylphenyl)-1-[(1S,2S,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.02,6]decan-4-yl]ethyl]amino]-1-oxopropan-2-yl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3793683; BDBM50163715
Click to Show/Hide
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||||
| Activity |
IC50 = 301995172 nM
|
[8] | |||
| Compound Name |
N-[(2S)-1-[[(1R)-2-(4-Fluorophenyl)-1-[(1S,2S,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.02,6]decan-4-yl]ethyl]amino]-1-oxo-3-phenylpropan-2-yl]pyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3792854; BDBM50163557
Click to Show/Hide
|
||||
| Activity |
IC50 = 309029543.3 nM
|
[8] | |||
| Compound Name |
(2S)-2-Acetamido-N-[(1R)-2-(4-methylphenyl)-1-[(1S,2S,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.02,6]decan-4-yl]ethyl]-3-phenylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3793863; BDBM50163704
Click to Show/Hide
|
||||
| Activity |
IC50 = 363078054.8 nM
|
[8] | |||
| Compound Name |
N-[(2S)-1-[[(1R)-3-Methyl-1-[(1S,2S,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.02,6]decan-4-yl]butyl]amino]-3-naphthalen-1-yl-1-oxopropan-2-yl]naphthalene-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3793093; BDBM50163693
Click to Show/Hide
|
||||
| Activity |
IC50 = 407380277.8 nM
|
[8] | |||
| Compound Name |
(2S)-2-Acetamido-N-[(1R)-3-methyl-1-[(1S,2S,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.02,6]decan-4-yl]butyl]-3-phenylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3792573; BDBM50163703
Click to Show/Hide
|
||||
| Activity |
IC50 = 426579518.8 nM
|
[8] | |||
| Compound Name |
N-[(2S)-1-[[(1R)-3-Methyl-1-[(1S,2S,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.02,6]decan-4-yl]butyl]amino]-1-oxo-3-phenylpropan-2-yl]pyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL606394; SCHEMBL12518944; BDBM50163555
Click to Show/Hide
|
||||
| Activity |
IC50 = 524807460.3 nM
|
[8] | |||
| Compound Name |
(1S)-N-[(2S)-1-Oxo-3-phenyl-1-[[(1R)-1-[(1S,2S,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.02,6]decan-4-yl]pentyl]amino]propan-2-yl]-1,2,3,4-tetrahydronaphthalene-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3792511; BDBM50163561
Click to Show/Hide
|
||||
| Activity |
IC50 = 524807460.3 nM
|
[8] | |||
| Compound Name |
[(1R)-3-Methyl-1-[[(2S)-3-phenyl-2-(5,6,7,8-tetrahydronaphthalene-1-carbonylamino)propanoyl]amino]butyl]boronic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL499504; BDBM50160868
Click to Show/Hide
|
||||
| Activity |
IC50 = 616595001.9 nM
|
[8] | |||
| Compound Name |
N-[(2S)-1-[[(1R)-3-Methyl-1-[(1S,2S,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.02,6]decan-4-yl]butyl]amino]-1-oxo-3-phenylpropan-2-yl]-1,2,3,4-tetrahydronaphthalene-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3793242; BDBM50163668
Click to Show/Hide
|
||||
| Activity |
IC50 = 691830970.9 nM
|
[8] | |||
| Compound Name |
N-[(2S)-1-[[(1R)-3-Methyl-1-[(1S,2S,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.02,6]decan-4-yl]butyl]amino]-3-naphthalen-1-yl-1-oxopropan-2-yl]-5,6,7,8-tetrahydronaphthalene-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3794207; BDBM50163689
Click to Show/Hide
|
||||
| Activity |
IC50 = 741310241.3 nM
|
[8] | |||
| Compound Name |
N-[(2S)-1-[[(1R)-3-Methyl-1-[(1S,2S,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.02,6]decan-4-yl]butyl]amino]-1-oxo-3-phenylpropan-2-yl]-5,6,7,8-tetrahydronaphthalene-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3793848; BDBM50163687
Click to Show/Hide
|
||||
| Activity |
IC50 = 758577575 nM
|
[8] | |||
| Compound Name |
(1S)-N-[(2S)-1-[[(1R)-2-(4-Fluorophenyl)-1-[(1S,2S,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.02,6]decan-4-yl]ethyl]amino]-1-oxo-3-phenylpropan-2-yl]-1,2,3,4-tetrahydronaphthalene-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3794136; BDBM50163565
Click to Show/Hide
|
||||
| Activity |
IC50 = 794328234.7 nM
|
[8] | |||
| Compound Name |
[(1R)-3-Methyl-1-[[(2S)-3-phenyl-2-[[(1S)-1,2,3,4-tetrahydronaphthalene-1-carbonyl]amino]propanoyl]amino]butyl]boronic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL499361; BDBM50160867
Click to Show/Hide
|
||||
| Activity |
IC50 = 831763771.1 nM
|
[8] | |||
| Compound Name |
N-[(2S)-1-[[(1R)-3-Methyl-1-[(1S,2S,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.02,6]decan-4-yl]butyl]amino]-3-naphthalen-2-yl-1-oxopropan-2-yl]-5,6,7,8-tetrahydronaphthalene-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3794310; BDBM50163698
Click to Show/Hide
|
||||
| Activity |
IC50 = 862978547.8 nM
|
[8] | |||
| Compound Name |
N-[(2S)-1-[[(1R)-2-(4-Methylphenyl)-1-[(1S,2S,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.02,6]decan-4-yl]ethyl]amino]-1-oxo-3-phenylpropan-2-yl]-1,2,3,4-tetrahydronaphthalene-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3793238; BDBM50163673
Click to Show/Hide
|
||||
| Activity |
IC50 = 862978547.8 nM
|
[8] | |||
| Compound Name |
N-[(2S)-4-Methyl-1-[[(1R)-3-methyl-1-[(1S,2S,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.02,6]decan-4-yl]butyl]amino]-1-oxopentan-2-yl]-5,6,7,8-tetrahydronaphthalene-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3793581; BDBM50163685
Click to Show/Hide
|
||||
| Activity |
IC50 = 868960429.3 nM
|
[8] | |||
| Compound Name |
(1S)-N-[(2S)-1-[[(1R)-3-Methyl-1-[(1S,2S,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.02,6]decan-4-yl]butyl]amino]-1-oxo-3-phenylpropan-2-yl]-1,2,3,4-tetrahydronaphthalene-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3794168; BDBM50163559
Click to Show/Hide
|
||||
| Activity |
IC50 = 893305483.7 nM
|
[8] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | A strategy for dual inhibition of the proteasome and fatty acid synthase with belactosin C-orlistat hybrids. Bioorg Med Chem. 2017 Jun 1;25(11):2901-2916. | ||||
| REF 2 | Optimization of subsite binding to the beta5 subunit of the human 20S proteasome using vinyl sulfones and 2-keto-1,3,4-oxadiazoles: syntheses and c... J Med Chem. 2006 May 18;49(10):2953-68. | ||||
| REF 3 | Incorporation of non-natural amino acids improves cell permeability and potency of specific inhibitors of proteasome trypsin-like sites. J Med Chem. 2013 Feb 14;56(3):1262-75. | ||||
| REF 4 | Ridaifen-F conjugated with cell-penetrating peptides inhibits intracellular proteasome activities and induces drug-resistant cell death. Eur J Med Chem. 2018 Feb 25;146:636-650. | ||||
| REF 5 | Terminal functionalized thiourea-containing dipeptides as multidrug-resistance reversers that target 20S proteasome and cell proliferation. Eur J Med Chem. 2017 Jan 27;126:259-269. | ||||
| REF 6 | Structure-based design of human immuno- and constitutive proteasomes inhibitors. Eur J Med Chem. 2018 Feb 10;145:570-587. | ||||
| REF 7 | Potent and Highly Selective Inhibitors of the Proteasome Trypsin-like Site by Incorporation of Basic Side Chain Containing Amino Acid Derived Sulfonyl Fluorides. J Med Chem. 2018 Jun 28;61(12):5395-5411. | ||||
| REF 8 | 3D-QSAR-aided design, synthesis, in vitro and in vivo evaluation of dipeptidyl boronic acid proteasome inhibitors and mechanism studies. Bioorg Med Chem. 2016 Jun 1;24(11):2576-88. | ||||
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