Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T49898 | Target Info | |||
| Target Name | Cyclin-dependent kinase 1 (CDK1) | ||||
| Synonyms |
P34CDC2; P34 protein kinase; CDKN1; CDC28A; CDC2
Click to Show/Hide
|
||||
| Target Type | Clinical trial Target | ||||
| Gene Name | CDK1 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 94 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Adenine
Click to Show/Hide
|
Approved | Compound Info | ||
| Synonyms |
ADE; ANE; Adenin; Adeninimine; Adenine [JAN]; Pedatisectine B; AD2; Vitamin B 4; Vitamin B4; ALBB-005925; Adenine (8CI); Adenine-ring; B 4, Vitamin; Leuco-4; Leucon (TN); Purine, 6; USAF CB-18; Vitamin-B4; Adenine (JAN/USP); Adenine-8-14C; 1,6-Dihydro-6-Imnopurine; 1,6-Dihydro-6-iminopurine; 1H-Purin-6-amine; 1H-Purin-6-amine (9CI); 1H-Purine, 6-amino; 2'-DEOXY-ADENOSINE-3'-5'-DIPHOSPHATE; 3,6-Dihydro-6-iminopurine; 4, Vitamin B; 6-Amino-1H-purine; 6-Amino-3H-purine; 6-Amino-7H-purine; 6-Amino-9H-purine; 6-Aminopurine; 7H-Purin-6-amine; 9H-Purin-6-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 200000 nM
|
[1] | |||
| Compound Name |
LEE011
Click to Show/Hide
|
Phase 3 | Compound Info | ||
| Synonyms |
Ribociclib; LEE011; 1211441-98-3; LEE-011; Kisqali; Ribociclib(LEE011); UNII-TK8ERE8P56; LEE 011; 7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide; TK8ERE8P56; Ribociclib (LEE011); AK174906; 7-cyclopentyl-N,N-dimethyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide; 7-cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7H-pyrrolo [2,3-d]pyrimidine-6-carboxylic acid dimethylamide; Ribociclib [USAN:INN]; LEE011A; Tube013
Click to Show/Hide
|
||||
| Activity |
IC50 = 113000 nM
|
[2] | |||
| Compound Name |
MLN8054
Click to Show/Hide
|
Phase 1 | Compound Info | ||
| Synonyms |
ZZL; MLN-8054
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
A-432411
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
43A; (3Z)-6-(4-HYDROXY-3-METHOXYPHENYL)-3-(1H-PYRROL-2-YLMETHYLENE)-1,3-DIHYDRO-2H-INDOL-2-ONE; 2ayp; indolinone analog 13; A-432411; CHEMBL202930; SCHEMBL6674605; BDBM14649; DB07078; 29690-EP2311842A2; 29690-EP2289868A1; 29690-EP2289894A2; (3Z)-6-(4-hydroxy-3-methoxyphenyl)-3-(1H-pyrrol-2-ylmethylidene)-1H-indol-2-one; (3Z)-6-(4-hydroxy-3-methoxyphenyl)-3-(1H-pyrrol-2-ylmethylidene)-2,3-dihydro-1H-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
CGP-62464
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CGP-62464; CHEMBL169757; 5,7-diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine; NSC606429; AC1Q4VCQ; 5,7-diphenyl-4-aminopyrrolo[2,3-d]pyrimidine; AC1L74EC; SCHEMBL5936176; ZINC1609260; BDBM50088900; NSC-606429; 121405-24-1; FT-0761196; 5,7-diphenylpyrrolo[2,3-d]pyrimidin-4-amine; 5,7-Diphenyl-7H-pyrrolo[2,3-d]pyrimidine-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 54000 nM
|
[5] | |||
| Compound Name |
JNJ-10198409
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
JNJ-10198409; 627518-40-5; PDGFR Tyrosine Kinase Inhibitor IV; PDGF Receptor Tyrosine Kinase Inhibitor IV; CHEMBL120077; N-(3-fluorophenyl)-6,7-dimethoxy-1,4-dihydroindeno[1,2-c]pyrazol-3-amine; 3-Fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamine; ZDNURMVOKAERHZ-UHFFFAOYSA-N; SCHEMBL3088170; GTPL6020; CTK8E8807; jnj10198409; DTXSID70430890; MolPort-009-019-131; HMS3650O03; HMS3229I11; ZINC13677843; BDBM50179207; AKOS030525202; RWJ 540973; CCG-206773; NCGC00343986-02; RT-014973; KB-274227; SR-01000946814
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
Ethyl 8-ethyl-9-oxo-[1,3]thiazolo[5,4-f]quinazoline-2-carboximidate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL506669; BDBM50247372; 8-Ethyl-9-oxo-8,9-dihydro-6-thiazolo[5,4-f]quinazoline-2-carboximidic acid ethyl ester
Click to Show/Hide
|
||||
| Activity |
IC50 = 50000 nM
|
[7] | |||
| Compound Name |
N-(7-Methoxyquinolin-6-yl)thieno[3,2-d]pyrimidine-7-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL357756; CHEMBL3822972; BDBM206104; DB-085143; US9255110, 17
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
(E)-4-(2-(4-Bromobenzylthio)-3-(4-fluoro-3-nitrophenyl)acryloyl)benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242482; SCHEMBL3193921; SCHEMBL3193924; BDBM50326061; 4-[(E)-2-[(4-bromophenyl)methylsulfanyl]-3-(4-fluoro-3-nitrophenyl)prop-2-enoyl]benzoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[9] | |||
| Compound Name |
(S)-N-(1-(3-Fluorobenzyl)-1H-indazol-5-yl)-5-((morpholin-2-ylmethoxy)methyl)pyrrolo[1,2-f][1,2,4]triazin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL246284; SCHEMBL2447488; BDBM50204134
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[10] | |||
| Compound Name |
3-(5-Chloro-2-{[1-(dimethylamino)propan-2-yl]oxy}phenyl)-1-(5-cyanopyrazin-2-yl)urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
urea-based inhibitor 2d; A-690002; CHEMBL425904; SCHEMBL5865729; BDBM14829; 1-[5-chloro-2-[1-(dimethylamino)propan-2-yloxy]phenyl]-3-(5-cyanopyrazin-2-yl)urea; (+/-)1-[5-Chloro-2-(2-dimethylamino-1-methyl-ethyloxy)-phenyl]-3-(5-cyano-pyrazin-2-yl)-urea
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[11] | |||
| Compound Name |
3-[(E)-2-(4-Chlorophenyl)ethenyl]-N-[(2R)-2,3-dihydroxypropyl]-4-methoxybenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1949788; SCHEMBL12134179; BDBM50364832; CH-4932748
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[12] | |||
| Compound Name |
Methyl 4-(6-(4-aminophenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1095626; SCHEMBL3984085; BDBM50316252; methyl 4-[6-(4-aminophenyl)-4-morpholin-4-ylpyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[13] | |||
| Compound Name |
[6-Chloro-4-methyl-3-[[3-(methylsulfamoylamino)phenyl]methyl]-2-oxochromen-7-yl] N,N-dimethylcarbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3086065; SCHEMBL959662; BDBM50443366
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[14] | |||
| Compound Name |
(R)-3-(6-(1-(2,6-Dichloro-3-fluorophenyl)ethoxy)quinolin-3-yl)acrylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL602471; BDBM50306677
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[15] | |||
| Compound Name |
3-[(E)-2-(4-Chlorophenyl)ethenyl]-N-[(2S)-2,3-dihydroxypropyl]-4-methoxybenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1949789; SCHEMBL12134185; BDBM50364833; CH-4932750
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[12] | |||
| Compound Name |
(R)-6-(1-(2,6-Dichloro-3-fluorophenyl)ethoxy)quinoline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL600795; BDBM50306683
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[15] | |||
| Compound Name |
4-[[6-(Ethylamino)-2-[[1-(phenylmethyl)-5-indolyl]amino]-4-pyrimidinyl]amino]-1-cyclohexanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Cdk4/6 Inhibitor IV; CHEMBL2028998; CHEMBL1242367; CGP82996; Cdk4/6InhibitorIV; SCHEMBL14040726; SCHEMBL14334441; SCHEMBL14334442; HMS2043N19; BDBM50378824; BDBM50503352; CINK4, >=95% (HPLC); AKOS016358850; ZINC101499579; CGP-082996; NCGC00346952-01; Q27163298
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[16] | |||
| Compound Name |
3-{5-Chloro-2-[(3-methyloxetan-3-yl)methoxy]phenyl}-1-(5-cyanopyrazin-2-yl)urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
urea-based inhibitor 2e; A-641397; CHEMBL192161; BDBM14830; (+/-)1-[5-Chloro-2-(3-methyl-oxetan-3-ylmethoxy)-phenyl]-3-(5-cyano-pyrazin-2-yl)-urea
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[11] | |||
| Compound Name |
2-(6-Amino-9-methyl-9H-purin-2-ylamino)-ethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL132369; SCHEMBL8008266; 2-hydroxyethylamino-9-methyladenine; BDBM50056172; 2-[(6-amino-9-methylpurin-2-yl)amino]ethanol
Click to Show/Hide
|
||||
| Activity |
IC50 = 50000 nM
|
[1] | |||
| Compound Name |
3-[4-(4-Hydroxyphenyl)phenyl]-N-(pyridin-4-ylmethyl)-1,4-dihydroindeno[1,2-c]pyrazole-6-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL242753; SCHEMBL6794625; BDBM50204693
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[17] | |||
| Compound Name |
3-(4'-Hydroxybiphenyl-4-Yl)-N-(4-Hydroxycyclohexyl)-1,4-Dihydroindeno[1,2-C]pyrazole-6-Carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL438485; SCHEMBL4809259; SCHEMBL4809267; BDBM91830; BDBM50204694; ZINC100469705; ZINC253994709; Q27456666
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[17] | |||
| Compound Name |
Tert-Butyl 4-(6-(4-aminophenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1095627; SCHEMBL3991434; BDBM50316253
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[13] | |||
| Compound Name |
2-(6-((R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy)quinolin-3-yl)cyclopropanecarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL602472; BDBM50306684; CH-5234152
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[15] | |||
| Compound Name |
2-[9-(4-Amino-3-methoxyphenyl)-6-oxo-5,11-dihydrobenzo[b][1,4]benzodiazepin-3-yl]-N-(4-morpholin-4-ylphenyl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL395080; BDBM50218700
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[18] | |||
| Compound Name |
N-[3-(2-Pyridin-4-ylpyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-3-(trifluoromethyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1089082; SCHEMBL4656083; BDBM50314051; N-(3-(2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[19] | |||
| Compound Name |
Tert-butyl N-[4-[[4-(3-chloroanilino)-2H-pyrazolo[3,4-d]pyrimidin-3-yl]amino]phenyl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
4-(Phenylamino)pyrazolo[3,4-d]pyrimidine deriv. 16; BDBM3015; CHEMBL120703; SCHEMBL8124691; 3-((4-(N-BOC-amino)phenyl)amino)-4-((3-chlorophenyl)amino)-1H-pyrazolo[3,4-d]pyrimidine; 3-[4-(N-BOC-amino)-phenylamino]-4-(3-chloro-phenylamino)-1H-pyrazolo[3,4-d]pyrimidine; tert-butyl N-[4-({4-[(3-chlorophenyl)amino]-1H-pyrazolo[3,4-d]pyrimidin-3-yl}amino)phenyl]carbamate
Click to Show/Hide
|
||||
| Activity |
IC50 = 57000 nM
|
[20] | |||
| Compound Name |
9-Bromo-12-prop-2-enyl-5,7-dihydroindolo[3,2-d][1]benzazepin-6-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL99280; Paullone Analog 43; BDBM7304; SCHEMBL5688608; 9-bromo-12-(2-propenyl)-paullone; NSC 704072; 9-Bromo-12-(2-propenyl)-7,12-dihydroindolo[3,2-d][1]benzazepine-6(5H)-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 60000 nM
|
[21] | |||
| Compound Name |
Benzamide, 4-[[4-amino-6-(cyclohexylmethoxy)-2-pyrimidinyl]amino]-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
4-((4-Amino-6-(cyclohexylmethoxy)pyrimidin-2-yl)amino)benzamide; 4-{[4-amino-6-(cyclohexylmethoxy)pyrimidin-2-yl]amino}benzamide; 2-arylamino-pyrimidine deriv. 8a; BDBM5589; CHEMBL319709; SCHEMBL12589617; CTK2E7584; DTXSID90416196; 4-[[6-(Cyclohexylmethoxy)-4-amino-2-pyrimidinyl]amino]benzamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 63000 nM
|
[22] | |||
| Compound Name |
6-Benzylamino-2-(1-hydroxymethyl-propylamino)-9-isopropyl-9H-purin-8-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL100670; BDBM50132195
Click to Show/Hide
|
||||
| Activity |
IC50 = 65000 nM
|
[23] | |||
| Compound Name |
2-[[9-Methyl-6-(3-methylbut-2-enylamino)purin-2-yl]amino]ethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL131382; BDBM50056165; 2-[9-Methyl-6-(3-methyl-but-2-enylamino)-9H-purin-2-ylamino]-ethanol
Click to Show/Hide
|
||||
| Activity |
IC50 = 65000 nM
|
[1] | |||
| Compound Name |
2-(8-Amino-6-benzylamino-9-isopropyl-9H-purin-2-ylamino)-butan-1-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL100500; BDBM50132188
Click to Show/Hide
|
||||
| Activity |
IC50 = 70000 nM
|
[23] | |||
| Compound Name |
Tert-butyl 9-bromo-6-oxo-5,7-dihydroindolo[3,2-d][1]benzazepine-12-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL100312; Paullone Analog 42; BDBM7303; SCHEMBL5688347; NSC 703057; 9-bromo-12-(tert-butyloxycarbonyl)-paullone; 9-Bromo-12-(tert-butoxycarbonyl)-7,12-dihydroindolo[3,2-d][1]benzazepine-6(5H)-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 70000 nM
|
[21] | |||
| Compound Name |
1-[[2-(9-Bromoindolo[3,2-b]quinoxalin-6-yl)acetyl]amino]-3-cyclohexyl-thiourea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
NSC698983; CHEMBL1973716; BDBM50078891; NSC-698983; NCI60_035386; 6H-Indolo[2,3-b]quinoxaline-6-acetic acid, 9-bromo-, 2-[(cyclohexylamino)thioxomethyl]hydrazide; N'-[Cyclohexylamino(thiocarbonyl)]-9-bromo-6H-indolo[2,3-b]quinoxaline-6-acetic acid hydrazide
Click to Show/Hide
|
||||
| Activity |
IC50 = 70000 nM
|
[24] | |||
| Compound Name |
2-Chloro-9-methyl-9H-purin-6-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-chloro-9-methylpurin-6-amine; 6-Amino-2-chloro-9-methylpurine; 9H-Purin-6-amine, 2-chloro-9-methyl-; CHEMBL317398; 2-chloro-9-methyladenine; SCHEMBL129921; CTK5D1900; DTXSID70220410; ZINC6072445; BDBM50009702; MFCD18433373; AKOS006370683; DS-5349; 2-Chloro-9-methyl-9H-purin-6-ylamine; AK126966; W-203568
Click to Show/Hide
|
||||
| Activity |
IC50 = 70000 nM
|
[1] | |||
| Compound Name |
2,6,9-Trisubstituted purine deriv. 5d
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL132948; BDBM7508; N-benzyl-9-cyclopentyl-2-iodo-9H-purin-6-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 75000 nM
|
[25] | |||
| Compound Name |
2-[6-(4-Chloro-phenylamino)-9-isopropyl-9H-purin-2-ylamino]-3-methyl-butan-1-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL77262; BDBM50113684
Click to Show/Hide
|
||||
| Activity |
IC50 = 80000 nM
|
[26] | |||
| Compound Name |
Ditert-butyl 9-bromo-6-oxo-7,12-dihydroindolo[3,2-d][1]benzazepine-5,7-dicarboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL100485; Paullone Analog 49; BDBM7310; SCHEMBL5688264; 9-bromo-5,7-bis-(tert-butyloxycarbonyl)-paullone; 9-Bromo-5,7-bis(tert-butoxycarbonyl)-7,12-dihydroindolo[3,2-d][1]benzazepine-6(5H)-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 80000 nM
|
[21] | |||
| Compound Name |
2-(4-(4-Amino-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)benzylamino)ethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL173453; SCHEMBL7841930; BDBM50088912; 2-[[4-(4-amino-5-phenylpyrrolo[2,3-d]pyrimidin-7-yl)phenyl]methylamino]ethanol; 2-[4-(4-Amino-5-phenyl-pyrrolo[2,3-d]pyrimidin-7-yl)-benzylamino]-ethanol; 4-Amino-5-phenyl-7-[4-(2-hydroxyethylaminomethyl)phenyl]-7H-pyrrolo[2,3-d]pyrimidine
Click to Show/Hide
|
||||
| Activity |
IC50 = 82500 nM
|
[5] | |||
| Compound Name |
2-Amino-6-benzylamino-9H-purine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL133214; MTH1 inhibitor, 53; 9H-Purine-2,6-diamine, N6-(phenylmethyl)-; SCHEMBL822377; SCHEMBL8014608; BDBM227632; 2-Amino-6-(benzylamino)-9H-purine; 6-N-benzyl-7H-purine-2,6-diamine; BDBM50056167; STL287855; ZINC12898066; AKOS022135389; N*6*-Benzyl-9H-purine-2,6-diamine; N~6~-benzyl-9H-purine-2,6-diamine; MCULE-6482100414; NCGC00168516-01; NCGC00168516-02
Click to Show/Hide
|
||||
| Activity |
IC50 = 90000 nM
|
[1] | |||
| Compound Name |
2,6,9-Trisubstituted purine deriv. 5e
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL335938; BDBM7509; N-benzyl-9-cyclohexyl-2-iodo-9H-purin-6-amine; 2-Iodo-N-benzyl-9-cyclohexyl-9H-purine-6-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 90000 nM
|
[25] | |||
| Compound Name |
7-Phenyl-5-o-tolyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL174634; SCHEMBL7842835; BDBM50088901; ZINC28093747; 5-(2-methylphenyl)-7-phenylpyrrolo[2,3-d]pyrimidin-4-amine; 5-(2-Methylphenyl)-7-phenyl-7H-pyrrolo[2,3-d]pyrimidine-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 90000 nM
|
[5] | |||
| Compound Name |
7-(5-(2-Morpholinoethoxy)-1H-indol-2-yl)isoindolin-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL483451; SCHEMBL5331815; BDBM50264579; 7-[5-(2-morpholin-4-ylethoxy)-1H-indol-2-yl]-2,3-dihydroisoindol-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
4-Amino-6-(4-(benzyloxy)-3-chlorophenylamino)pyrimidine-5-carbohydrazide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL511478; SCHEMBL1096310; BDBM50245445; 4-amino-6-(3-chloro-4-phenylmethoxyanilino)pyrimidine-5-carbohydrazide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[28] | |||
| Compound Name |
Tert-butyl N-[4-[4-(3-chloroanilino)-2H-pyrazolo[3,4-d]pyrimidin-3-yl]phenyl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM3028; CHEMBL420885; SCHEMBL8117280; 4-(Phenylamino)pyrazolo[3,4-d]pyrimidine deriv. 29; 3-(4-(BOC-amino)phenyl)-4-((3-chlorophenyl)amino)-1H-pyrazolo[3,4-d]pyrimidine; 3-(4-tert-butoxycarbonylamino-phenyl)-4-(3-chloro-phenylamino)-1H-pyrazolo[3,4-d]pyrimidine; 3-[4-(tert-Butyloxycarbonylamino)phenyl]-N-(3-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; tert-butyl N-(4-{4-[(3-chlorophenyl)amino]-1H-pyrazolo[3,4-d]pyrimidin-3-yl}phenyl)carbamate
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
4-Amino-6-(4-(benzyloxy)-3-chlorophenylamino)-N-(2-methoxyethyl)pyrimidine-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL517745; SCHEMBL13873522; BDBM50245409
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[28] | |||
| Compound Name |
4-Amino-6-(4-(benzyloxy)-3-chlorophenylamino)-N-phenylpyrimidine-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL461114; SCHEMBL3974260; BDBM50245363; 4-amino-6-(3-chloro-4-phenylmethoxyanilino)-N-phenylpyrimidine-5-carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[28] | |||
| Compound Name |
4-Amino-6-(4-(benzyloxy)-3-chlorophenylamino)-N-(2-(piperidin-1-yl)ethyl)pyrimidine-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL462343; SCHEMBL13873521; BDBM50245364
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[28] | |||
| Compound Name |
2-Hydroxy-5-[2-(1-hydroxymethyl-2-methyl-propylamino)-9-isopropyl-9H-purin-6-ylamino]-benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL74799; BDBM50113692
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[26] | |||
| Compound Name |
5-(3-Chlorophenyl)-7-phenyl-4-aminopyrrolo[2,3-d]pyrimidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL176309; SCHEMBL7844427; BDBM50088910; 5-(3-chlorophenyl)-7-phenylpyrrolo[2,3-d]pyrimidin-4-amine; 5-(3-Chloro-phenyl)-7-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine; 5-(3-chlorophenyl)-7-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine; 5-(3-Chlorophenyl)-7-phenyl-7H-pyrrolo[2,3-d]pyrimidine-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
2-[6-Benzylamino-8-(3-hydroxy-propylamino)-9-isopropyl-9H-purin-2-ylamino]-butan-1-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL318289; BDBM50132194
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
7-(5-(3-(4-Hydroxypiperidin-1-yl)propoxy)-1H-indol-2-yl)isoindolin-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL522601; BDBM50264551
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
7-(5-(Benzyloxy)-1H-indol-2-yl)isoindolin-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL484678; SCHEMBL5312152; BDBM50264613; 7-(5-phenylmethoxy-1H-indol-2-yl)-2,3-dihydroisoindol-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
N-(4-Benzyloxy-3-chloro-phenyl)-5-[5-(2-morpholin-4-yl-ethyl)-[1,3,4]oxadiazol-2-yl]-pyrimidine-4,6-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL472545; SCHEMBL1096374; BDBM50245472
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[28] | |||
| Compound Name |
7-(5-(3-(4-Ethylpiperazin-1-yl)propoxy)-1H-indol-2-yl)isoindolin-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL489820; SCHEMBL5456619; BDBM50264550; 7-[5-[3-(4-ethylpiperazin-1-yl)propoxy]-1H-indol-2-yl]-2,3-dihydroisoindol-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
2-(6-Benzylamino-9-isopropyl-8-propoxy-9H-purin-2-ylamino)-butan-1-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL317865; BDBM50132200
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
Tert-butyl 2-(2-methyl-3-oxoisoindolin-4-yl)-1H-pyrrole-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL491243; SCHEMBL5332117; BDBM50264549; tert-butyl 2-(2-methyl-3-oxo-1H-isoindol-4-yl)pyrrole-1-carboxylate; 2-(2-methyl-3-oxo-2,3-dihydro-1H-isoindol-4-yl)-pyrrole-1-carboxylic acid tert-butyl ester
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
7-(5-(3-Hydroxypropoxy)-1H-indol-2-yl)isoindolin-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL449663; SCHEMBL5327042; BDBM50264576; 7-[5-(3-hydroxypropoxy)-1H-indol-2-yl]-2,3-dihydroisoindol-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
4-Amino-6-(4-(benzyloxy)-3-chlorophenylamino)-N-(4-methoxyphenyl)pyrimidine-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL472383; SCHEMBL13873526; BDBM50245443
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[28] | |||
| Compound Name |
2-(6-Benzylamino-8-bromo-9-isopropyl-9H-purin-2-ylamino)-butan-1-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL320873; BDBM50132191
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
4-Amino-6-(4-(benzyloxy)-3-chlorophenylamino)-N-(2-morpholinoethyl)pyrimidine-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL518646; SCHEMBL13873523; BDBM50245407
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[28] | |||
| Compound Name |
2,6-Diaminopurine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
9H-Purine-2,6-diamine; 2-Aminoadenine; 7H-purine-2,6-diamine; 1H-Purine-2,6-diamine; 2,6-diamino-9h-purine; Purine, 2,6-diamino-; NSC 743; SQ 21065; 26-diaminopurine; 2,6-Diamino-purin-9-yl; 2,6-Diaminopurine, 98%; UNII-49P95BAU4Z; purine-2,6-diamine; 49P95BAU4Z; CHEMBL388596; MFCD00213668; Purine-2,6-diyldiamine; CCRIS 923; EINECS 217-605-2; AI3-25010; CCRIS 3903; 2-6-Diaminopurine; Purine,6-diamino-; 2,6-diamino-purine; PubChem9203; Purine, 2, 6-diamino-; Oprea1_670021; SCHEMBL24052; 9H-Purine-2,6-diamine #; KSC179A1B; MLS001066366; NSC743; DTXSID0062052; SCHEMBL16513167; CTK0H9010; CTK7E0750; NSC-743; (2-amino-7H-purin-6-yl)-amine; HMS2267N10; ALBB-023319; BCP30955; ZINC7486121; ANW-23487; BDBM50208879; MFCD00047146; MFCD00071537; SBB000103; AKOS003368184; AKOS015896933; AKOS028109333; 9H-Purine-2,6-diamine0.5M H2SO4; AC-8693; AM81387; GS-3048; LS20247; MCULE-1333744381; 9H-Purine-2,6-diamine;2-Aminoadenine; AK-68382; BP-13206; SC-02056; SMR000112503; ST012425; SY036886; TS-00060; AB0010986; DB-015922; D1625; FT-0610530; S-8021; 904D989; AC-907/34116038; Q-200204; Q4596802; W-203543
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
3-Fluorobenzyl 4-amino-6-(4-(benzyloxy)-3-chlorophenylamino)pyrimidine-5-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL472382; SCHEMBL3977223; BDBM50245442; (3-fluorophenyl)methyl 4-amino-6-(3-chloro-4-phenylmethoxyanilino)pyrimidine-5-carboxylate
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[28] | |||
| Compound Name |
(5R)-5-[(2E,7E,9E)-13-(3-Furanyl)-2,6,10-trimethyl-2,7,9-tridecatrienyl]-4-hydroxy-3-methyl-2(5H)-furanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
palinurin; CHEMBL464381
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[29] | |||
| Compound Name |
4-Amino-6-(4-(benzyloxy)-3-chlorophenylamino)-N''-(3-morpholinopropanoyl)pyrimidine-5-carbohydrazide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL472544; SCHEMBL1096489; BDBM50245471
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[28] | |||
| Compound Name |
4-Amino-6-(4-(benzyloxy)-3-chlorophenylamino)-N,N-diethylpyrimidine-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL452727; SCHEMBL4090152; BDBM50245410; 4-amino-6-(3-chloro-4-phenylmethoxyanilino)-N,N-diethylpyrimidine-5-carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[28] | |||
| Compound Name |
N,9-Dibenzyl-2-iodopurin-6-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL133477; 2,6,9-Trisubstituted purine deriv. 5f; BDBM7510; N,9-dibenzyl-2-iodo-9H-purin-6-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[25] | |||
| Compound Name |
2-[9-Isopropyl-6-(4-methoxy-benzylamino)-9H-purin-2-ylamino]-4-methyl-pentan-1-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL77732; BDBM50113722
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[26] | |||
| Compound Name |
N-Benzyl-N-methyl-4-(phenylsulfamoyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3355482; BDBM50043416; ZINC17334508; AKOS008571954; Z31474376
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
4-(3-Chloro-phenylamino)-3-(3-nitro-phenyl)-1H-pyrazolo[3,4-d]pyrimidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM3026; CHEMBL118904; SCHEMBL8115438; ZINC3815230; N-(3-chlorophenyl)-3-(3-nitrophenyl)-2H-pyrazolo[3,4-d]pyrimidin-4-amine; DA-22709; 4-(Phenylamino)pyrazolo[3,4-d]pyrimidine deriv. 27; 3-(3-nitro-phenyl)-4-(3-chloro-phenylamino)-1H-pyrazolo[3,4-d]pyrimidine; 3-(3-Nitrophenyl)-4-((3-chlorophenyl)amino)-1H-pyrazolo[3,4-d]pyrimidine; 3-(3-Nitrophenyl)-N-(3-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; N-(3-chlorophenyl)-3-(3-nitrophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
7-(1H-Indol-2-yl)isoindolin-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL482621; SCHEMBL5333071; BDBM50264612; 7-(1H-indol-2-yl)-2,3-dihydroisoindol-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
N-(4-Methoxyphenethyl)-4-amino-6-(4-(benzyloxy)-3-chlorophenylamino)pyrimidine-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL461115; SCHEMBL13873524; BDBM50245408
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[28] | |||
| Compound Name |
N-(3-Bromophenyl)-6,7-dimethoxyquinazolin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
PD153035; PD-153035; pd 153035; UNII-TC62B68RSL; 4-(3-BROMOANILINO)-6,7-DIMETHOXYQUINAZOLINE; AG-1517; SU 5271; 4-(3-bromophenylamino)-6,7-dimethoxyquinazoline; AG 1517; NSC-669364; PD-153035 free base; SU-5271; TC62B68RSL; CHEMBL29197; 153436-54-5 (free base); (3-Bromophenyl)(6,7-dimethoxyquinazolin-4-yl)amine; 4-QUINAZOLINAMINE, N-(3-BROMOPHENYL)-6,7-DIMETHOXY-; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline; C16H14BrN3O2; 4-[(3-Bromophenyl)amino]-6,7-dimethoxyquinazoline; SR-01000597835; WHI-P-79; InSolution PD 153035; GI 230329A; PubChem22449; Tocris-1037; SCHEMBL9423; AG-1517 HCl; BDBM3032; LSPANGZZENHZNJ-UHFFFAOYSA-; AOB6127; DTXSID80165328; ZINC600292; BCP00569; EX-A1235; KS-00000I0V; ANW-48127; HSCI1_000100; MFCD00934896; QC-948; s6546; AKOS003676410; BCP9001062; CS-0143; DS-1673; VZ27722; NCGC00024956-01; NCGC00024956-02; NCGC00024956-04; NCGC00024956-18; NCGC00024956-19; AC-32897; AK-50931; AM808088; BR-50931; HY-14346; SC-27623; AB0022472; DB-028592; FT-0643505; W3343; PD 153035(AG-1517); K00043; N-(3-bromophenyl)-6,7-dimethoxyquinazolin-4-; S-7071; J-009016; J-523873; SR-01000597835-2; 4-Quinazolinamine,N-(3-bromophenyl)-6,7-dimethoxy-; BRD-K26603252-001-01-9; Q27163047; PD 153035 - CAS 153436-54-5; PD 153035; SU 5271; 4-[(3-Bromophenyl)amino]-6,7-dimethoxyquinazoline
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[20] | |||
| Compound Name |
7-(5-(3-(Piperidin-1-yl)propoxy)-1H-indol-2-yl)isoindolin-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL485081; SCHEMBL5328153; BDBM50264578; 7-[5-(3-piperidin-1-ylpropoxy)-1H-indol-2-yl]-2,3-dihydroisoindol-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
7-(5-Methoxy-1H-indol-2-yl)isoindolin-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL520975; SCHEMBL5314912; BDBM50264580; 7-(5-methoxy-1H-indol-2-yl)-2,3-dihydroisoindol-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
N-(3-Chlorophenyl)-3-(4-methoxyphenyl)-2H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM3024; CHEMBL332971; SCHEMBL8115114; 4-(Phenylamino)pyrazolo[3,4-d]pyrimidine deriv. 25; 3-(4-Methoxyphenyl)-4-((3-chlorophenyl)amino)-1H-pyrazolo[3,4-d]pyrimidine; 3-(4-Methoxyphenyl)-N-(3-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; 4-(3-chloro-phenylamino)-3-(4-methoxy-phenyl)-1H-pyrazolo[3,4-d]pyrimidine; N-(3-chlorophenyl)-3-(4-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
7-(5-(2-(Piperidin-1-yl)ethoxy)-1H-indol-2-yl)isoindolin-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL484876; SCHEMBL5327067; BDBM50264577; 7-[5-(2-piperidin-1-ylethoxy)-1H-indol-2-yl]-2,3-dihydroisoindol-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
6-(Cyclohexylmethoxy)-9-methyl-9h-purin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
NU-6052; NU6052; CHEMBL94794; BDBM5565; CTK7E0950; NSC707617; O6-Cyclohexylmethyl-N9-methylguanine; NSC-707617; NCI60_038219; 2-amino-6-cyclohexylmethoxy-N(sup 9)-methylpurine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[31] | |||
| Compound Name |
Methyl 6-((5-cyanopyrazin-2-yl)amino)-4-((piperidin-4-ylmethyl)amino)nicotinate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1928692; SCHEMBL618393; BDBM50359819; ZINC82154500; methyl 6-(5-cyanopyrazin-2-ylamino)-4-(piperidin-4-ylmethylamino)nicotinate; methyl 6-(5-cyanopyrazin-2-ylamino)-4-(piperidin-4-ylmethylamino)-nicotinate; methyl 6-[(5-cyanopyrazin-2-yl)amino]-4-(piperidin-4-ylmethylamino)pyridine-3-carboxylate
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[32] | |||
| Compound Name |
6-(Adamantylamino)-2-[(3-hydroxypropyl)amino]-9-isopropylpurine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
purine deriv. 8; CHEMBL83719; BDBM10640; 3-{[6-(1-adamantylamino)-9-isopropyl-9H-purin-2-yl]amino}propan-1-ol; 3-[[9-Isopropyl-6-(adamantane-1-ylamino)-9H-purine-2-yl]amino]propane-1-ol; 3-{[6-(adamantan-1-ylamino)-9-(propan-2-yl)-9H-purin-2-yl]amino}propan-1-ol
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[33] | |||
| Compound Name |
(3Z)-3-[(2,4,6-Trimethoxyphenyl)methylidene]-1H-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL404941; MLS002153404; SCHEMBL905701; SCHEMBL3697594; 3-[(2,4,6-trimethoxyphenyl)methylidene]-2,3-dihydro-1H-indol-2-one; HMS2230A20; BDBM50375651; ZINC12339629; NCGC00485035-01; SMR001230782; IC 261, >=98% (HPLC); BRD-K19535922-001-01-2
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[34] | |||
| Compound Name |
2,6,9-Trisubstituted purine deriv. 8
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL133740; BDBM7513; 2-{[9-(propan-2-yl)-6-(1,2,3,6-tetrahydropyridin-1-yl)-9H-purin-2-yl]amino}ethan-1-ol
Click to Show/Hide
|
||||
| Activity |
IC50 = 110000 nM
|
[25] | |||
| Compound Name |
(5,6-Diphenyl-furo[2,3-D]pyrimidin-4-ylamino)-acetic
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
furanopyrimidine compound 3; CHEMBL364811; BDBM14801; 2-({5,6-diphenylfuro[2,3-d]pyrimidin-4-yl}(methyl)amino)ethan-1-ol; DB07654; Q27096873; 2-[(5,6-Diphenyl-furo[2,3-d]pyrimidin-4-yl)-methylamino]-ethanol; 2-[(5,6-diphenylfuro[2,3-d]pyrimidin-4-yl)(methyl)amino]ethanol
Click to Show/Hide
|
||||
| Activity |
IC50 = 111400 nM
|
[35] | |||
| Compound Name |
2-[1-(9-Isopropyl-6-phenylamino-9H-purin-2-yl)-piperidin-2-yl]-ethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL308714; BDBM50113700
Click to Show/Hide
|
||||
| Activity |
IC50 = 130000 nM
|
[26] | |||
| Compound Name |
(2-Chloro-9-methyl-9H-purin-6-yl)-cyclohexyl-methyl-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL337161; BDBM50056173
Click to Show/Hide
|
||||
| Activity |
IC50 = 130000 nM
|
[1] | |||
| Compound Name |
2-[9-Isopropyl-6-(4-methoxy-benzylamino)-9H-purin-2-ylamino]-butan-1-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL310590; Methoxy-roscovitine; SCHEMBL3718983; BDBM50113724
Click to Show/Hide
|
||||
| Activity |
IC50 = 130000 nM
|
[26] | |||
| Compound Name |
2,6,9-Trisubstituted purine deriv. 7
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL336176; BDBM7512; 2-({6-[methyl(prop-2-en-1-yl)amino]-9-(propan-2-yl)-9H-purin-2-yl}amino)ethan-1-ol
Click to Show/Hide
|
||||
| Activity |
IC50 = 150000 nM
|
[25] | |||
| Compound Name |
6-Chloro-2-iodo-9-isopropyl-9H-purine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL337291; 6-chloro-2-iodo-9-propan-2-ylpurine; 2,6,9-Trisubstituted purine deriv. 4b; BDBM7504; SCHEMBL2314138; CTK0J8514; DTXSID50424878; 2-Iodo-6-chloro-9-isopropyl-9H-purine; 6-chloro-2-iodo-9-(propan-2-yl)-9H-purine; 9H-Purine, 6-chloro-2-iodo-9-(1-methylethyl)-
Click to Show/Hide
|
||||
| Activity |
IC50 = 150000 nM
|
[25] | |||
| Compound Name |
Tritert-butyl 9-bromo-6-oxo-7H-indolo[3,2-d][1]benzazepine-5,7,12-tricarboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL420455; Paullone Analog 53; BDBM7314; SCHEMBL5688965; 9-bromo-5,7,12-tri-(tert-butyloxycarbonyl)-paullone
Click to Show/Hide
|
||||
| Activity |
IC50 = 150000 nM
|
[21] | |||
| Compound Name |
2-[1-(6-Benzylamino-9-isopropyl-9H-purin-2-yl)-piperidin-2-yl]-ethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL76592; BDBM50113738
Click to Show/Hide
|
||||
| Activity |
IC50 = 160000 nM
|
[26] | |||
| Compound Name |
2-[6-(3-Iodo-benzylamino)-9-isopropyl-9H-purin-2-ylamino]-3-methyl-butan-1-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL76761; BDBM50113754
Click to Show/Hide
|
||||
| Activity |
IC50 = 170000 nM
|
[26] | |||
| Compound Name |
2,6,9-Trisubstituted purine deriv. 25
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM7530; CHEMBL3085250; [(2R)-1-[9-benzyl-6-(benzylamino)-9H-purin-2-yl]pyrrolidin-2-yl]methanol; 2-[(2R)-2-(Hydroxymethyl)pyrrolizino]-9,N-dibenzyl-9H-purine-6-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 200000 nM
|
[25] | |||
| Compound Name |
2-[(6-Amino-7H-purin-2-yl)amino]ethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL130306; Ethanol, 2-[(6-amino-9H-purin-2-yl)amino]-; SCHEMBL8009119; BDBM50056161; 2-(6-Amino-9H-purin-2-ylamino)-ethanol
Click to Show/Hide
|
||||
| Activity |
IC50 = 200000 nM
|
[1] | |||
| Compound Name |
6-Benzylaminopurine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Benzyladenine; N6-Benzyladenine; N-Benzyladenine; N-Benzyl-9H-purin-6-amine; 6-Benzyladenine; 6-(Benzylamino)purine; Cytokinin B; 6-BAP; N-benzyl-7H-purin-6-amine; Adenine, N-benzyl-; Benzyl(purin-6-yl)amine; N(6)-Benzylaminopurine; Aminopurine, 6-benzyl; 1H-PURIN-6-AMINE, N-(PHENYLMETHYL)-; BA (Growth stimulant); BAP (growth stimulant); N(sup 6)-Benzyladenine; 6-Benzyl adenine; 6-(N-Benzylamino)purine; N-6-Benzyladenine; Verdan senescence inhibitor; N-(Phenylmethyl)-1H-purin-6-amine; N(sup 6)-(Benzylamino)purine; N(6)-(benzylamino)purine; UNII-KXG6A989PS; SD 4901; SQ 4609; benzylpurin-6-ylamine; 6-(n-benzyl)aminopurine; 6-[(phenylmethyl)amino]-9H-purine; MFCD00005572; 6-(Benzylamino)-9H-purine; KXG6A989PS; N-benzyl-1H-purin-6-amine; MLS000532693; CHEMBL228862; benzyl-(7h-purin-6-yl)-amine; n(6)-benzyladenine; n6-benzylaminopurine; 9H-Purin-6-amine, N-(phenylmethyl)-; benzylaminopurine, 6-; SMR000140130; Pro-Shear; 6-Benzylaminopurine, 99%; Caswell No. 081EE; 6-benzyladenine 6-benzylaminopurine; Adenine, N(sup 6)-benzyl-; CCRIS 4351; ABG 3034; EINECS 214-927-5; NSC 40818; HSDB 7667; N-Benzyl-adenine; Benzyl Aminopurine; BAP (cytokinin); Prestwick_414; 6-benzylamino purine; PubChem9266; Adenine, N6-benzyl-; N-Benzyladenine, 8CI; N(Sup6)-Benzyladenine; BA (growth stimulator); ACMC-1CACB; Opera_ID_868; Prestwick0_000189; Prestwick1_000189; Prestwick2_000189; Prestwick3_000189; N(Sup 6)-benzyl-Adenine; CBKinase1_000521; CBKinase1_012921; Cambridge id 5131951; TimTec1_001722; DSSTox_CID_12630; DSSTox_RID_79014; DSSTox_GSID_32630; Oprea1_747691; Oprea1_785203; Oprea1_830563; SCHEMBL35562; BSPBio_000117; CBDivE_001815; MLS001074298; N6-benzyl-9H-purin-6-amine; SPBio_002038; 6-Benzylaminopurine, 99.0%; BPBio1_000129; DTXSID7032630; CTK4D1317; CTK5J6355; NWBJYWHLCVSVIJ-UHFFFAOYSA-; ZINC43479; HMS1538O06; HMS1568F19; HMS1667I06; HMS2095F19; HMS2234B24; HMS3374C09; HMS3712F19; HY-B0941; NSC40818; STR06184; 6-Benzylaminopurine; Benzyl Kinetin; N-(phenylmethyl)-7H-purin-6-amine; Tox21_301307; ANW-17632; BDBM50205363; CCG-55533; GEO-00296; MFCD00051031; N-(Phenylmethyl)-9H-Purin-6-amine; NSC-40818; s4511; STK858495; AKOS002304241; AKOS005257767; 7H-purin-6-amine, N-(phenylmethyl)-; AC-5488; AM84356; CCG-220189; KS-5285; LS40236; MCULE-1256228871; PS-3425; 6-Benzylaminopurine, analytical standard; KS-00000A54; N-benzyl-9H-purin-6-amine, AldrichCPR; NCGC00016571-01; NCGC00016571-02; NCGC00016571-03; NCGC00016571-04; NCGC00016571-05; NCGC00255357-01; AK-47425; BR-47425; SC-00593; ST020598; SY014632; 6-Benzylaminopurine, >=99.0% (HPLC); B1088; FT-0620956; EN300-40176; 14B397; 6-Benzylaminopurine, plant cell culture tested; A13053; B-1000; C11263; M-4965; Q419946; SR-01000644553; 6-Benzylaminopurine, Vetec(TM) reagent grade, 98%; SR-01000644553-1; SR-01000644553-2; BA ; N6-Benzyladenine ; N6-Benzyladenine ; BA; BRD-K62929068-001-05-8; BRD-K62929068-001-15-7; F0578-0089; 2B76FFBD-3C3A-4349-9047-E5B8945B54A7
Click to Show/Hide
|
||||
| Activity |
IC50 = 200000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 101 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Miltefosine
Click to Show/Hide
|
Approved | Compound Info | ||
| Synonyms |
HDPC; HePC; Hexadecylphosphocholine; Hexadecylphosphorylcholine; Impavido; Miltefosina; Miltefosinum; Miltex; Baxter Oncology brand of miltefosine; Baxter brand of miltefosine; Miltefosin C; Prasfarma brand of miltefosine; D 18506; IN1227; D-18506; H-1850; M-7200; Miltefosina [INN-Spanish]; Miltefosine (INN); Miltefosine[INN:BAN]; Miltefosinum [INN-Latin]; N-Hexadecylphosphorylcholine; TF-002; Choline hydroxide, hexadecyl hydrogen phosphate, inner salt; Choline, hexadecyl hydrogen phosphate, inner salt; Hexadecyl 2-(trimethylazaniumyl)ethyl phosphate; Choline phosphate, hexadecyl ester, hydroxide, inner salt; Choline phosphate, hexadecyl ester, hydroxide, inner salt (6CI); Hexadecyl 2-(trimethyl-.lambda.~5~-azanyl)ethyl hydrogen phosphate; Ethanaminium, 2-(((hexadecyloxy)hydroxyphosphinyl)oxy)-N,N,N-trimethyl-, hydroxide, inner salt; Ethanaminium, 2-(((hexadecyloxy)hydroxyphosphinyl)oxy)-N,N,N-trimethyl-, hydroxide, innner salt; 1-Hexadecylphosphorylcholine; 2-(((Hexadecyloxy)hydroxyphosphinyl)oxy)-N,N,N-trimethylethanaminium hydroxide, inner salt; 3,5-Dioxa-4-phosphaunacosan-1-aminium, 4-hydroxy-N,N,N-trimethyl-, hydroxide, inner salt, 4-oxide
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[36] | |||
| Compound Name |
PMID17480064C16
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
724711-21-1; 3fhr; 2jbp; 2jbo; P4O; Pyrrolopyridine, 16; Kinome_3179; 3r2y; GTPL8177; BDBM30185; ZINC16052855; AKOS027322581; DB08358; KB-19275; DB-013997; FT-0745988
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[37] | |||
| Compound Name |
N-(5,6-DIPHENYLFURO[2,3-D]PYRIMIDIN-4-YL)GLYCINE
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
(5,6-Diphenyl-furo[2,3-d]pyrimidin-4-ylamino)-acetic acid; N-(5,6-DIPHENYLFURO[2,3-D]PYRIMIDIN-4-YL)GLYCINE; 701223-63-4; DFW; 2-[(5,6-diphenylfuro[2,3-d]pyrimidin-4-yl)amino]acetic acid; 2-({5,6-diphenylfuro[2,3-d]pyrimidin-4-yl}amino)acetic acid; 2brh; CBKinase1_018018; furanopyrimidine compound 4; CBKinase1_005618; AC1LI48C; SCHEMBL6748456; CHEMBL363302; BDBM14802; MolPort-002-125-656; ZINC383023; AKOS015957210; MCULE-9828982030; DB07653; L-3296; SR-01000273355; SR-01000273355-1; BRD-K42410867-001-01-6; F1684-0511
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[35] | |||
| Compound Name |
9-Methyl-9H-adenine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
9-Methyl-9H-purin-6-ylamine
Click to Show/Hide
|
||||
| Activity |
IC50 > 350000 nM
|
[1] | |||
| Compound Name |
2-[(5,6-Diphenylfuro[2,3-D]pyrimidin-4-YL)amino]ethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
ChemDiv2_003927; furanopyrimidine compound 2; Oprea1_754661; CHEMBL189434; SCHEMBL12355054; BDBM14800; 2-(5,6-Diphenyl-furo[2,3-d]pyrimidin-4-ylamino)-ethanol; HMS1380C11; HMS3604K10; 2-({5,6-diphenylfuro[2,3-d]pyrimidin-4-yl}amino)ethan-1-ol; ZINC1803337; CCG-19059; STK012643; AKOS000663532; DB08393; MCULE-8789421392; IDI1_002642; ST056633; Q27097605; 2-[(5,6-diphenylfurano[3,2-e]pyrimidin-4-yl)amino]ethan-1-ol
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[35] | |||
| Compound Name |
2-{1-[9-Isopropyl-6-(4-methoxy-benzylamino)-9H-purin-2-yl]-piperidin-2-yl}-ethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL80674; BDBM50113750
Click to Show/Hide
|
||||
| Activity |
IC50 = 210000 nM
|
[26] | |||
| Compound Name |
2-[[6-(3-Chloro-phenylamino)-9-isopropyl-9H-purin-2-yl]-(2-hydroxy-ethyl)-amino]-ethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL77610; BDBM50113729
Click to Show/Hide
|
||||
| Activity |
IC50 = 220000 nM
|
[26] | |||
| Compound Name |
2-(2-Hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
NG 52; compound 52; NG-52; compound 52 [PMID: 9677190]; CHEMBL311228; 2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)-9H-purin-2-yl}amino)ethan-1-ol; C16H19ClN6O; 2-((6-((3-chlorophenyl)amino)-9-isopropyl-9H-purin-2-yl)amino)ethan-1-ol; compound52; Compound 52; 2-(2-Hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine; NG 52 (Compound 52 ); GTPL5955; SCHEMBL1181087; CTK8A5312; AOB5486; DTXSID80274388; 2,6,9-Trisubstitute purine, 2; HMS3229E14; 2-[[6-(3-chloroanilino)-9-propan-2-ylpurin-2-yl]amino]ethanol; BCP15154; ZINC2391782; 3925AH; BDBM50113707; HSCI1_000070; MFCD02179196; s6540; AKOS026750316; CCG-206834; CS-1187; DB08325; NCGC00378928-02; HY-15154; A12494; K00015; K00222; W-5285; BRD-K02909970-001-01-9; BRD-K02909970-001-02-7; Q27076720; 2-(6-(3-chlorophenylamino)-9-isopropyl-9H-purin-2-ylamino)ethanol; 2-({6-[(3-Chlorophenyl)amino]-9-isopropyl-9H-purin-2-yl}amino)ethanol; 2-[6-(3-Chloro-phenylamino)-9-isopropyl-9H-purin-2-ylamino]-ethanol; 2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)-9h-purin-2-yl}amino)ethanol
Click to Show/Hide
|
||||
| Activity |
IC50 = 220000 nM
|
[26] | |||
| Compound Name |
2-[9-Isopropyl-6-(4-methoxy-benzylamino)-9H-purin-2-ylamino]-3-methyl-butan-1-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL80898; SCHEMBL4422868; BDBM50113737; (2R)-2-[[6-[(4-methoxyphenyl)methylamino]-9-propan-2-ylpurin-2-yl]amino]-3-methylbutan-1-ol
Click to Show/Hide
|
||||
| Activity |
IC50 = 230000 nM
|
[26] | |||
| Compound Name |
2-{1-[6-(4-Amino-benzylamino)-9-isopropyl-9H-purin-2-yl]-piperidin-2-yl}-ethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL310271; BDBM50113726
Click to Show/Hide
|
||||
| Activity |
IC50 = 230000 nM
|
[26] | |||
| Compound Name |
3-[[6-(3-Chloroanilino)-9-isopropyl-purin-2-yl]-(2-hydroxyethyl)amino]propan-1-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL77064; MLS000911546; REGID_for_CID_757551; cid_16746003; HMS2043C01; HMS2218H03; REGID_for_CID_16746003; BDBM50113682; SMR000463562
Click to Show/Hide
|
||||
| Activity |
IC50 = 230000 nM
|
[26] | |||
| Compound Name |
2-(9-Isopropyl-6-phenylamino-9H-purin-2-ylamino)-3-methyl-butan-1-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL76670; BDBM50113747
Click to Show/Hide
|
||||
| Activity |
IC50 = 240000 nM
|
[26] | |||
| Compound Name |
3-{(2-Hydroxy-ethyl)-[9-isopropyl-6-(4-methoxy-benzylamino)-9H-purin-2-yl]-amino}-propan-1-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL80225; BDBM50113751
Click to Show/Hide
|
||||
| Activity |
IC50 = 250000 nM
|
[26] | |||
| Compound Name |
9-Bromo-4-methoxy-7,12-dihydro-5H-indolo[3,2-d][1]benzazepin-6-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL330398; NSC702373; Paullone Analog 47; 9-bromo-4-methoxypaullone; BDBM7308; SCHEMBL5688257; CTK7B0387; NSC 702373; NSC-702373; NCI60_036666; 9-bromo-4-methoxy-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5h)-one; 9-Bromo-4-methoxy-7,12-dihydroindolo[3,2-d][1]benzazepine-6(5H)-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 250000 nM
|
[21] | |||
| Compound Name |
6-Chloro-9-cyclopentyl-9H-purin-2-ylamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL335743; SCHEMBL6473284; 6-chloro-9-cyclopentylpurin-2-amine; BDBM50093398; 9-Cyclopentyl-6-chloro-9H-purine-2-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 260000 nM
|
[25] | |||
| Compound Name |
2-[6-(3-Bromo-phenylamino)-9-isopropyl-9H-purin-2-ylamino]-ethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL80916; BDBM50113743
Click to Show/Hide
|
||||
| Activity |
IC50 = 270000 nM
|
[26] | |||
| Compound Name |
2-[6-(3-Chloro-4-fluoro-phenylamino)-9-isopropyl-9H-purin-2-ylamino]-ethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL415270; MLS000911585; HMS2043F19; HMS2218I18; HMS3358D13; BDBM50113697; SMR000718278
Click to Show/Hide
|
||||
| Activity |
IC50 = 290000 nM
|
[26] | |||
| Compound Name |
(2R)-2-[[6-(3-Chloroanilino)-9-isopropyl-purin-2-yl]amino]butan-1-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL306783; MLS000911551; cid_16746116; HMS2228F06; REGID_for_CID_16746116; BDBM50113680; SMR000463567; (R)-2-(6-(3-chlorophenylamino)-9-isopropyl-9H-purin-2-ylamino)butan-1-ol; 2-[6-(3-Chloro-phenylamino)-9-isopropyl-9H-purin-2-ylamino]-butan-1-ol
Click to Show/Hide
|
||||
| Activity |
IC50 = 300000 nM
|
[26] | |||
| Compound Name |
1-[6-(3-Chloro-phenylamino)-9-isopropyl-9H-purin-2-ylamino]-indan-2-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL79764; BDBM50113721
Click to Show/Hide
|
||||
| Activity |
IC50 = 300000 nM
|
[26] | |||
| Compound Name |
Benzyl-(3-methyl-3,9-dihydro-2H-purin-6-yl)-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL336556; BDBM50056162
Click to Show/Hide
|
||||
| Activity |
IC50 = 300000 nM
|
[1] | |||
| Compound Name |
2-Methyladenine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-Methyl-1H-purin-6-amine; 2-methyl-7H-purin-6-amine; methyladenine; 2-Methyl-6-aminopurine; SQ 23354; ADENINE, 2-METHYL-; 1H-Purin-6-amine, 2-methyl- (9CI); CHEMBL330897; 1H-Purin-6-amine, 2-methyl-; 2-methyladenin; methyl-3h-adenine; 2-methylpurin-6-amine; SCHEMBL19779; 2-methyl-9H-purin-6-amine; 1h-purin-6-amine,2-methyl-; 2-Methyl-9H-purin-6-ylamine; 9H-Purin-6-amine, 2-methyl-; KS-00000SCH; DTXSID80162731; (2-methyl-9H-purin-6-yl)-amine; BCP29033; NSC26364; ZINC1628368; BDBM50030961; MFCD01674065; NSC-26364; AKOS006338122; AKOS015905348; AKOS024463815; DS-8040; AK163291; SQ 23,354; 1H-Purin-6-amine pound not 2-methyl- (9CI); A808223; Q15632702
Click to Show/Hide
|
||||
| Activity |
IC50 = 320000 nM
|
[1] | |||
| Compound Name |
2-[6-(3-Chloro-4-fluoro-phenylamino)-9-isopropyl-9H-purin-2-ylamino]-3-methyl-butan-1-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL80213; BDBM50113749
Click to Show/Hide
|
||||
| Activity |
IC50 = 360000 nM
|
[26] | |||
| Compound Name |
2-[[6-(3-Fluoroanilino)-9-isopropyl-purin-2-yl]amino]ethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL309978; MLS000911537; SCHEMBL5839426; HMS2043A07; HMS2214O19; HMS3330H12; BDBM50113711; SMR000463553; 2-[[6-(3-fluoroanilino)-9-propan-2-ylpurin-2-yl]amino]ethanol; 2-[6-(3-Fluoro-phenylamino)-9-isopropyl-9H-purin-2-ylamino]-ethanol; 6-(3-fluoro-phenyl-amino)-2-(2-hydroxy-ethyl-amino)-9-isopropyl-9H-purine
Click to Show/Hide
|
||||
| Activity |
IC50 = 400000 nM
|
[26] | |||
| Compound Name |
(2R)-2-[[6-(3-Chloroanilino)-9-propan-2-ylpurin-2-yl]amino]-2-phenylethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL311571; BDBM50113710
Click to Show/Hide
|
||||
| Activity |
IC50 = 400000 nM
|
[26] | |||
| Compound Name |
2-[9-Isopropyl-6-(3-methoxy-phenylamino)-9H-purin-2-ylamino]-ethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL311741; BDBM50113731
Click to Show/Hide
|
||||
| Activity |
IC50 = 400000 nM
|
[26] | |||
| Compound Name |
3-Methyl-3,9-dihydro-2H-purin-6-ylamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL131896; BDBM50056171
Click to Show/Hide
|
||||
| Activity |
IC50 = 400000 nM
|
[1] | |||
| Compound Name |
2-[9-Isopropyl-6-(3-trifluoromethyl-phenylamino)-9H-purin-2-ylamino]-ethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL79329; BDBM50113756
Click to Show/Hide
|
||||
| Activity |
IC50 = 420000 nM
|
[26] | |||
| Compound Name |
4-Methoxy-7,12-dihydro-5H-indolo[3,2-d][1]benzazepin-6-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL99423; 4-methoxypaullone; NSC701591; Paullone Analog 50; BDBM7311; SCHEMBL5688599; CTK7B0388; NSC 701591; NSC-701591; NCI60_036441; 4-methoxy-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5h)-one; 4-Methoxy-7,12-dihydroindolo[3,2-d][1]benzazepine-6(5H)-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 430000 nM
|
[21] | |||
| Compound Name |
{1-[9-Isopropyl-6-(4-methoxy-benzylamino)-9H-purin-2-ylamino]-cyclopentyl}-methanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL306183; BDBM50113720
Click to Show/Hide
|
||||
| Activity |
IC50 = 450000 nM
|
[26] | |||
| Compound Name |
2,6,9-Trisubstituted purine deriv. 6
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL129973; BDBM7511; 2-({9-methyl-6-[methyl(prop-2-en-1-yl)amino]-9H-purin-2-yl}amino)ethan-1-ol
Click to Show/Hide
|
||||
| Activity |
IC50 = 470000 nM
|
[25] | |||
| Compound Name |
Paullone Analog 48
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL97844; 9-bromo-5-ethylpaullone; BDBM7309; NSC 706121; 5-Ethyl-7,12-dihydro-9-bromoindolo[3,2-d][1]benzazepine-6(5H)-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 470000 nM
|
[21] | |||
| Compound Name |
7-Methyl-8,9-dihydro-7H-purin-6-ylamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL334619; SCHEMBL20096935; BDBM50056175
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[1] | |||
| Compound Name |
2-[6-(3-Chloro-phenylamino)-9-isopropyl-9H-purin-2-ylamino]-3-methyl-butan-1-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL80611; SR-01000076068; NG-60; (S)-Purvalanol A; Lopac0_000938; ZINC582580; BDBM50113746; CCG-205019; P 4484; SR-01000076068-1; SR-01000076068-3; SR-01000076068-4
Click to Show/Hide
|
||||
| Activity |
IC50 = 500000 nM
|
[26] | |||
| Compound Name |
2-[6-(3-Chloro-phenylamino)-9-isopropyl-9H-purin-2-ylamino]-3-methyl-pentan-1-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL309227; BDBM50113704
Click to Show/Hide
|
||||
| Activity |
IC50 = 500000 nM
|
[26] | |||
| Compound Name |
{1-[6-(3-Chloro-phenylamino)-9-isopropyl-9H-purin-2-ylamino]-cyclopentyl}-methanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL305823; BDBM50113728
Click to Show/Hide
|
||||
| Activity |
IC50 = 500000 nM
|
[26] | |||
| Compound Name |
2-[6-(3-Chloro-phenylamino)-9-isopropyl-9H-purin-2-ylamino]-3-phenyl-propan-1-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL77365; BDBM50113755
Click to Show/Hide
|
||||
| Activity |
IC50 = 500000 nM
|
[26] | |||
| Compound Name |
(2R)-2-[[6-(3-Chloroanilino)-9-isopropyl-purin-2-yl]amino]-4-methyl-pentan-1-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL80586; SMR000463568; MLS000911552; MLS003105947; HMS2221M10; BDBM50113696; 2-[6-(3-Chloro-phenylamino)-9-isopropyl-9H-purin-2-ylamino]-4-methyl-pentan-1-ol
Click to Show/Hide
|
||||
| Activity |
IC50 = 530000 nM
|
[26] | |||
| Compound Name |
2-[9-Isopropyl-6-(4-methoxy-benzylamino)-9H-purin-2-ylamino]-propane-1,3-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL75795; BDBM50113736
Click to Show/Hide
|
||||
| Activity |
IC50 = 560000 nM
|
[26] | |||
| Compound Name |
(2S)-2-[[6-[(4-Methoxyphenyl)methylamino]-9-propan-2-ylpurin-2-yl]amino]-3-methylbutan-1-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL415271; BDBM50113732
Click to Show/Hide
|
||||
| Activity |
IC50 = 600000 nM
|
[26] | |||
| Compound Name |
{1-[6-(3-Chloro-phenylamino)-9-isopropyl-9H-purin-2-yl]-pyrrolidin-2-yl}-methanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL77369; BDBM50113706; CHEMBL132628; SCHEMBL13046775; BDBM50093397; (R){1-[6-(3-Chloro-phenylamino)-9-isopropyl-9H-purin-2-yl]-pyrrolidin-2-yl}-methanol; 6-(3-Chloroanilino)-2-[(2R)-2-(hydroxymethyl)pyrrolizino]-9-isopropyl-9H-purine
Click to Show/Hide
|
||||
| Activity |
IC50 = 620000 nM
|
[26] | |||
| Compound Name |
2-[9-Isopropyl-6-(4-methoxy-benzylamino)-9H-purin-2-ylamino]-ethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL80754; BDBM50113727
Click to Show/Hide
|
||||
| Activity |
IC50 = 700000 nM
|
[26] | |||
| Compound Name |
2-{1-[6-(4-Chloro-phenylamino)-9-isopropyl-9H-purin-2-yl]-piperidin-2-yl}-ethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL419094; BDBM50113687
Click to Show/Hide
|
||||
| Activity |
IC50 = 790000 nM
|
[26] | |||
| Compound Name |
2-[6-(3-Chloro-phenylamino)-9-isopropyl-9H-purin-2-ylamino]-2-phenyl-ethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL432356; BDBM50113691
Click to Show/Hide
|
||||
| Activity |
IC50 = 800000 nM
|
[26] | |||
| Compound Name |
3-[[6-(3-Chloroanilino)-9-isopropyl-purin-2-yl]amino]propan-1-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL80895; MLS000911548; cid_16746117; HMS2043C05; HMS2228B10; HMS3356F15; REGID_for_CID_16746117; BDBM50113745; SMR000463564; 3-[6-(3-Chloro-phenylamino)-9-isopropyl-9H-purin-2-ylamino]-propan-1-ol
Click to Show/Hide
|
||||
| Activity |
IC50 = 900000 nM
|
[26] | |||
| Compound Name |
(N-Methylpiperidino)ethanol 2-(tetradecyloxy)ethyl phosphonate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL86560; BDBM50051815
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[36] | |||
| Compound Name |
(N-Methylmorpholino)ethanol 2-(dodecyloxy)ethyl phosphonate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL86791; BDBM50051814
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[36] | |||
| Compound Name |
Ditert-butyl 9-bromo-6-oxo-7H-indolo[3,2-d][1]benzazepine-5,12-dicarboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL317562; Paullone Analog 54; BDBM7315; SCHEMBL5688664; NSC 702374; 9-bromo-5,12-bis-(tert-butyloxycarbonyl)-paullone; 9-Bromo-6-oxo-6,7-dihydroindolo[3,2-d][1]benzoazepine-5,12-dicarboxylic acid di-tert-butyl ester
Click to Show/Hide
|
||||
| Activity |
IC50 = 1000000 nM
|
[21] | |||
| Compound Name |
Dodecyl 2-(4-methylmorpholin-4-ium-4-yl)ethyl phosphate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL418940; BDBM50051806
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[36] | |||
| Compound Name |
(N-Methylmorpholino)ethanol 2-(hexadecyloxy)ethyl phosphonate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL89292; BDBM50051807
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[36] | |||
| Compound Name |
(N-Methylmorpholino)ethanol hexadecyl phosphonate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL88487; BDBM50051809; Hexadecyl[2-(N-Methylmorpholinio)ethyl]phosphate
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[36] | |||
| Compound Name |
2-{[9-Isopropyl-6-(4-methoxy-benzylamino)-9H-purin-2-yl]-methyl-amino}-1-phenyl-ethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL80562; BDBM50113695
Click to Show/Hide
|
||||
| Activity |
IC50 = 1000000 nM
|
[26] | |||
| Compound Name |
(N-Methylpiperidino)ethanol 2-(hexadecyloxy)ethyl phosphonate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL89013; BDBM50051810
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[36] | |||
| Compound Name |
2-Chloroadenine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-chloro-7H-purin-6-amine; 2-chloro-9H-purin-6-amine; 2-Chloro-6-aminopurine; 6-Amino-2-chloropurine; Adenine, 2-chloro-; MFCD00037925; 1H-Purin-6-amine, 2-chloro-; CHEMBL134192; 9H-purin-6-amine, 2-chloro-; 6-AMINO-2-CHLORO-PURINE; 6-AMINO-2-CHLORO-7H-PURINE; 2-chloradenin; ClAde; PubChem9259; AI3-52061; 2-Chloroadenine, 97%; 2-chloro-6-amino purine; 2-chloropurine-6-ylamine; UNII-A05OL9V6OM; A05OL9V6OM; ACMC-1C6X9; CLADRIBINE IMPURITY C; SCHEMBL29745; 2-chloro-1H-purin-6-amine; Purine, 6-amino-2-chloro-; KSC234S4F; 2-chloro-1H-purine-6-amine; 2-Chloro-9H-purin-6-ylamine; CTK1D4942; DTXSID30171515; NSC7362; AM799; BCP20072; KS-000000YJ; NSC-7362; ZINC4411053; ANW-23177; BBL101268; BDBM50056180; SBB052056; STL555064; AKOS005257637; AKOS006281627; AKOS028109325; AB01672; AC-1007; LS40260; PS-4933; 2-Chloro-9H-purin-6-amine, AldrichCPR; AK-28668; AK-77180; BR-28668; SC-01941; SQ 22982; SY035219; AB0008578; DB-005233; SQ 22,982; FT-0601064; 2-Chloro-7H-purin-6-amine (2-Chloroadenine); M-2829; 839C185; Q-200260; Cladribine impurity C, European Pharmacopoeia (EP) Reference Standard
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[1] | |||
| Compound Name |
(N-Methylmorpholino)ethanol 2-(tetradecycloxy)ethyl phosphonate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL89650; BDBM50051811
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[36] | |||
| Compound Name |
Hexadecyl 2-(1-methylpiperidinium-1-yl)ethyl phosphate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL89618; BDBM50051816; (N-methylpiperidino)ethanol hexadecyl phosphonate; Hexadecyl[2-(N-Methylpiperidinio)ethyl]phosphate; D-20317
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[36] | |||
| Compound Name |
1-Methyl-9H-purin-6-ylamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL422980; SCHEMBL2254463; BDBM50056166
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[1] | |||
| Compound Name |
(N-Methylpiperidino)ethanol dodecyl phosphonate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL89135; BDBM50051812
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[36] | |||
| Compound Name |
10-Chloro-6-hydroxybenzo [c]quinolizinium chloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL175225; SCHEMBL2081163; SCHEMBL2081165
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[38] | |||
| Compound Name |
Benzyl-(7-methyl-8,9-dihydro-7H-purin-6-yl)-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL133377; BDBM50056179
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[1] | |||
| Compound Name |
(N-Methylpiperidino)ethanol tetradecyl phosphonate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL314931; BDBM50051813
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[36] | |||
| Compound Name |
Benzyl-(1-methyl-6,9-dihydro-1H-purin-6-yl)-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL133290; BDBM50056181
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[1] | |||
| Compound Name |
2-(4-Methylmorpholin-4-ium-4-yl)ethyl tetradecyl phosphate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL89141; BDBM50051808
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[36] | |||
| Compound Name |
2-{Ethyl-[9-isopropyl-6-(4-methoxy-benzylamino)-9H-purin-2-yl]-amino}-ethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL80920; BDBM50113709
Click to Show/Hide
|
||||
| Activity |
IC50 = 1200000 nM
|
[26] | |||
| Compound Name |
3-[9-Isopropyl-6-(4-methoxy-benzylamino)-9H-purin-2-ylamino]-propan-1-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL77413; BDBM50113757
Click to Show/Hide
|
||||
| Activity |
IC50 = 1200000 nM
|
[26] | |||
| Compound Name |
2-(1-{9-Isopropyl-6-[(naphthalen-2-ylmethyl)-amino]-9H-purin-2-yl}-piperidin-2-yl)-ethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL76917; BDBM50113748
Click to Show/Hide
|
||||
| Activity |
IC50 = 1200000 nM
|
[26] | |||
| Compound Name |
2-[1-(6-Butylamino-9-isopropyl-9H-purin-2-yl)-piperidin-2-yl]-ethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL80859; BDBM50113698
Click to Show/Hide
|
||||
| Activity |
IC50 = 1300000 nM
|
[26] | |||
| Compound Name |
3-[9-Isopropyl-6-(4-methoxy-benzylamino)-9H-purin-2-ylamino]-propane-1,2-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL312530; BDBM50113694
Click to Show/Hide
|
||||
| Activity |
IC50 = 1300000 nM
|
[26] | |||
| Compound Name |
2-{1-[9-Isopropyl-6-(3-phenyl-propylamino)-9H-purin-2-yl]-piperidin-2-yl}-ethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL80701; BDBM50113741
Click to Show/Hide
|
||||
| Activity |
IC50 = 1300000 nM
|
[26] | |||
| Compound Name |
2-{1-[6-(3-Chloro-phenylamino)-9-isopropyl-9H-purin-2-yl]-piperidin-2-yl}-ethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL80693; BDBM50113744
Click to Show/Hide
|
||||
| Activity |
IC50 = 1400000 nM
|
[26] | |||
| Compound Name |
2-{1-[9-Isopropyl-6-(2-phenylamino-ethylamino)-9H-purin-2-yl]-piperidin-2-yl}-ethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL79491; BDBM50113699
Click to Show/Hide
|
||||
| Activity |
IC50 = 1500000 nM
|
[26] | |||
| Compound Name |
1-Amino-3-[9-isopropyl-6-(4-methoxy-benzylamino)-9H-purin-2-ylamino]-propan-2-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL419830; BDBM50113713
Click to Show/Hide
|
||||
| Activity |
IC50 = 1600000 nM
|
[26] | |||
| Compound Name |
2-[6-(3-Chloro-phenylamino)-9-isopropyl-9H-purin-2-ylamino]-3,3-dimethyl-butan-1-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL540188; BDBM50113752
Click to Show/Hide
|
||||
| Activity |
IC50 = 2300000 nM
|
[26] | |||
| Compound Name |
2-[6-(2,4-Dichloro-phenylamino)-9-isopropyl-9H-purin-2-ylamino]-ethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL75633; BDBM50113683
Click to Show/Hide
|
||||
| Activity |
IC50 = 2700000 nM
|
[26] | |||
| Compound Name |
2-[9-Isopropyl-6-(4-methoxy-benzylamino)-9H-purin-2-ylamino]-1-phenyl-ethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL75319; BDBM50113688
Click to Show/Hide
|
||||
| Activity |
IC50 = 2800000 nM
|
[26] | |||
| Compound Name |
2-{Benzyl-[9-isopropyl-6-(4-methoxy-benzylamino)-9H-purin-2-yl]-amino}-ethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL420571; BDBM50113740
Click to Show/Hide
|
||||
| Activity |
IC50 = 2800000 nM
|
[26] | |||
| Compound Name |
2-{1-[9-Isopropyl-6-(2-trifluoromethyl-benzylamino)-9H-purin-2-yl]-piperidin-2-yl}-ethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL77291; BDBM50113708
Click to Show/Hide
|
||||
| Activity |
IC50 = 3000000 nM
|
[26] | |||
| Compound Name |
6-N-(3-Chlorophenyl)-9-propan-2-yl-2-N-[[2-(trifluoromethyl)phenyl]methyl]purine-2,6-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL306288; BDBM50113714; N*6*-(3-Chloro-phenyl)-9-isopropyl-N*2*-(2-trifluoromethyl-benzyl)-9H-purine-2,6-diamine
Click to Show/Hide
|
||||
| Activity |
IC50 = 4000000 nM
|
[26] | |||
| Compound Name |
(2-Azepan-1-yl-9-isopropyl-9H-purin-6-yl)-(4-methoxy-benzyl)-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL76784; NG38; BDBM50102697; N-[2-(Azepan-1-yl)-9-isopropyl-9H-purin-6-yl]-4-methoxybenzylamine; (2-Azepan-1-yl-9-isopropyl-9H-purin-6-yl)-(4-methoxy-benzyl)-amine(NG38)
Click to Show/Hide
|
||||
| Activity |
IC50 = 4000000 nM
|
[26] | |||
| Compound Name |
2-[6-(2-Chloro-phenylamino)-9-isopropyl-9H-purin-2-ylamino]-ethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL307367; BDBM50113689
Click to Show/Hide
|
||||
| Activity |
IC50 = 4300000 nM
|
[26] | |||
| Compound Name |
6-N-(3-Chlorophenyl)-2-N-[2-(dimethylamino)ethyl]-9-propan-2-ylpurine-2,6-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL309495; BDBM50113715; N*6*-(3-Chloro-phenyl)-N*2*-(2-dimethylamino-ethyl)-9-isopropyl-9H-purine-2,6-diamine
Click to Show/Hide
|
||||
| Activity |
IC50 = 4400000 nM
|
[26] | |||
| Compound Name |
2-{[6-(3-Chloro-phenylamino)-9-isopropyl-9H-purin-2-yl]-ethyl-amino}-3-methyl-butan-1-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL77122; BDBM50113701
Click to Show/Hide
|
||||
| Activity |
IC50 = 5000000 nM
|
[26] | |||
| Compound Name |
2-{Benzyl-[6-(3-chloro-phenylamino)-9-isopropyl-9H-purin-2-yl]-amino}-ethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL312406; BDBM50113690
Click to Show/Hide
|
||||
| Activity |
IC50 = 5000000 nM
|
[26] | |||
| Compound Name |
2-[6-(3-Chloro-phenylamino)-9-isopropyl-9H-purin-2-ylamino]-3-cyclohexyl-propan-1-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL311488; BDBM50113717
Click to Show/Hide
|
||||
| Activity |
IC50 = 5000000 nM
|
[26] | |||
| Compound Name |
2-{Benzyl-[6-(3-chloro-phenylamino)-9-isopropyl-9H-purin-2-yl]-amino}-3-methyl-butan-1-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL80755; BDBM50113702
Click to Show/Hide
|
||||
| Activity |
IC50 = 5000000 nM
|
[26] | |||
| Compound Name |
2-[[6-(3-Chloro-phenylamino)-9-isopropyl-9H-purin-2-yl]-(3-fluoro-benzyl)-amino]-3-methyl-butan-1-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL445311; SMR000463566; MLS000911550; MLS000911603; MLS003105946; HMS2222M19; BDBM50113733
Click to Show/Hide
|
||||
| Activity |
IC50 = 5000000 nM
|
[26] | |||
| Compound Name |
(2R)-1-[[6-(3-Chloroanilino)-9-propan-2-ylpurin-2-yl]amino]-2,3-dihydro-1H-inden-2-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL77145; BDBM50113734
Click to Show/Hide
|
||||
| Activity |
IC50 = 5000000 nM
|
[26] | |||
| Compound Name |
2-N-Benzyl-2-N-[2-(dimethylamino)ethyl]-6-N-[(4-methoxyphenyl)methyl]-9-propan-2-ylpurine-2,6-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL75809; BDBM50113685; N*2*-Benzyl-N*2*-(2-dimethylamino-ethyl)-9-isopropyl-N*6*-(4-methoxy-benzyl)-9H-purine-2,6-diamine
Click to Show/Hide
|
||||
| Activity |
IC50 = 5000000 nM
|
[26] | |||
| Compound Name |
2-{[6-(3-Chloro-phenylamino)-9-isopropyl-9H-purin-2-yl]-cyclohexylmethyl-amino}-3-methyl-butan-1-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL77119; BDBM50113681
Click to Show/Hide
|
||||
| Activity |
IC50 = 5300000 nM
|
[26] | |||
| Compound Name |
2-{1-[6-(3-Iodo-benzylamino)-9-isopropyl-9H-purin-2-yl]-piperidin-2-yl}-ethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL77126; BDBM50113712
Click to Show/Hide
|
||||
| Activity |
IC50 = 6000000 nM
|
[26] | |||
| Compound Name |
1-[9-Isopropyl-6-(4-methoxy-benzylamino)-9H-purin-2-yl]-piperidin-4-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL75924; BDBM50113723
Click to Show/Hide
|
||||
| Activity |
IC50 = 6500000 nM
|
[26] | |||
| Compound Name |
2-N-Benzyl-6-N-(3-chlorophenyl)-2-N-[2-(dimethylamino)ethyl]-9-propan-2-ylpurine-2,6-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL80402; BDBM50113718; N*2*-Benzyl-N*6*-(3-chloro-phenyl)-N*2*-(2-dimethylamino-ethyl)-9-isopropyl-9H-purine-2,6-diamine
Click to Show/Hide
|
||||
| Activity |
IC50 = 7000000 nM
|
[26] | |||
| Compound Name |
2-{4-[9-Isopropyl-6-(4-methoxy-benzylamino)-9H-purin-2-yl]-piperazin-1-yl}-ethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL78227; BDBM50113753
Click to Show/Hide
|
||||
| Activity |
IC50 = 7000000 nM
|
[26] | |||
| Compound Name |
2-{1-[6-(3,3-Diphenyl-propylamino)-9-isopropyl-9H-purin-2-yl]-piperidin-2-yl}-ethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL80758; BDBM50113719
Click to Show/Hide
|
||||
| Activity |
IC50 = 9000000 nM
|
[26] | |||
| Compound Name |
2-[9-Isopropyl-6-(2-methoxy-phenylamino)-9H-purin-2-ylamino]-ethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL75973; BDBM50113735
Click to Show/Hide
|
||||
| Activity |
IC50 = 9000000 nM
|
[26] | |||
| Compound Name |
2-[[6-(3-Chloro-phenylamino)-9-isopropyl-9H-purin-2-yl]-(4-methyl-benzyl)-amino]-3-methyl-butan-1-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL80203; BDBM50113705
Click to Show/Hide
|
||||
| Activity |
IC50 = 10000000 nM
|
[26] | |||
| Compound Name |
2-[[6-(3-Chloro-phenylamino)-9-isopropyl-9H-purin-2-yl]-(4-fluoro-benzyl)-amino]-3-methyl-butan-1-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL276120; BDBM50113686
Click to Show/Hide
|
||||
| Activity |
IC50 = 10000000 nM
|
[26] | |||
| Compound Name |
2-[9-Isopropyl-6-(2-trifluoromethyl-phenylamino)-9H-purin-2-ylamino]-ethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL307891; BDBM50113742
Click to Show/Hide
|
||||
| Activity |
IC50 = 10000000 nM
|
[26] | |||
| Compound Name |
2-(4-Methylpiperazino)-6-(4-methoxybenzylamino)-9-isopropyl-9H-purine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL76921; BDBM50102704; [9-Isopropyl-2-(4-methyl-piperazin-1-yl)-9H-purin-6-yl]-(4-methoxy-benzyl)-amine; [9-Isopropyl-2-(4-methyl-piperazin-1-yl)-9H-purin-6-yl]-(4-methoxy-benzyl)-amine(NG13)
Click to Show/Hide
|
||||
| Activity |
IC50 = 10800000 nM
|
[26] | |||
| Compound Name |
2-[6-(4-Amino-3-chloro-phenylamino)-9-isopropyl-9H-purin-2-ylamino]-3-methyl-butan-1-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL78214; BDBM50113730
Click to Show/Hide
|
||||
| Activity |
IC50 = 33000000 nM
|
[26] | |||
| Compound Name |
2-[6-(3-Amino-4-chloro-phenylamino)-9-isopropyl-9H-purin-2-ylamino]-3-methyl-butan-1-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL311354; BDBM50113693
Click to Show/Hide
|
||||
| Activity |
IC50 = 52000000 nM
|
[26] | |||
| Compound Name |
2-[9-Isopropyl-6-(naphthalen-2-ylamino)-9H-purin-2-ylamino]-ethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL80168; BDBM50113716
Click to Show/Hide
|
||||
| Activity |
IC50 = 430000000 nM
|
[26] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Cytokinin-derived cyclin-dependent kinase inhibitors: synthesis and cdc2 inhibitory activity of olomoucine and related compounds. J Med Chem. 1997 Feb 14;40(4):408-12. | ||||
| REF 2 | US patent application no. 8962630B2, Pyrrolopyrimidine compounds and their uses | ||||
| REF 3 | Synthesis, SAR and biological evaluation of 1,6-disubstituted-1H-pyrazolo[3,4-d]pyrimidines as dual inhibitors of Aurora kinases and CDK1. Bioorg Med Chem Lett. 2012 Mar 1;22(5):2070-4. | ||||
| REF 4 | Synthesis and biological evaluation of 3-ethylidene-1,3-dihydro-indol-2-ones as novel checkpoint 1 inhibitors. Bioorg Med Chem Lett. 2006 Jan 15;16(2):421-6. | ||||
| REF 5 | Substituted 5,7-diphenyl-pyrrolo[2,3d]pyrimidines: potent inhibitors of the tyrosine kinase c-Src. Bioorg Med Chem Lett. 2000 May 1;10(9):945-9. | ||||
| REF 6 | (6,7-Dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamines: platelet-derived growth factor receptor tyrosine kinase inhibitors with broad ant... J Med Chem. 2005 Dec 29;48(26):8163-73. | ||||
| REF 7 | Novel 9-oxo-thiazolo[5,4-f]quinazoline-2-carbonitrile derivatives as dual cyclin-dependent kinase 1 (CDK1)/glycogen synthase kinase-3 (GSK-3) inhibitors: synthesis, biological evaluation and molecular modeling studies. Eur J Med Chem. 2008 Jul;43(7):1469-77. | ||||
| REF 8 | Identification of a selective inhibitor of transforming growth factor -activated kinase 1 by biosensor-based screening of focused libraries. Bioorg Med Chem Lett. 2017 Feb 15;27(4):1031-1036. | ||||
| REF 9 | Design, synthesis and evaluation of (E)-alpha-benzylthio chalcones as novel inhibitors of BCR-ABL kinase. Bioorg Med Chem. 2010 Mar 15;18(6):2317-2326. | ||||
| REF 10 | 5-((4-Aminopiperidin-1-yl)methyl)pyrrolotriazine dual inhibitors of EGFR and HER2 protein tyrosine kinases. Bioorg Med Chem Lett. 2007 Sep 1;17(17):4947-54. | ||||
| REF 11 | 1-(5-Chloro-2-alkoxyphenyl)-3-(5-cyanopyrazin-2-yl)ureas [correction of cyanopyrazi] as potent and selective inhibitors of Chk1 kinase: synthesis, preliminary SAR, and biological activities. J Med Chem. 2005 May 5;48(9):3118-21. | ||||
| REF 12 | Angiogenesis inhibitors identified by cell-based high-throughput screening: synthesis, structure-activity relationships and biological evaluation of 3-[(E)-styryl]benzamides that specifically inhibit endothelial cell proliferation. Bioorg Med Chem. 2012 Feb 15;20(4):1442-60. | ||||
| REF 13 | Discovery of 4-morpholino-6-aryl-1H-pyrazolo[3,4-d]pyrimidines as highly potent and selective ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR): optimization of the 6-aryl substituent. J Med Chem. 2009 Dec 24;52(24):8010-24. | ||||
| REF 14 | The sulfamide moiety affords higher inhibitory activity and oral bioavailability to a series of coumarin dual selective RAF/MEK inhibitors. Bioorg Med Chem Lett. 2013 Dec 1;23(23):6223-7. | ||||
| REF 15 | Discovery of 6-benzyloxyquinolines as c-Met selective kinase inhibitors. Bioorg Med Chem Lett. 2010 Feb 15;20(4):1405-9. | ||||
| REF 16 | Selectivity and potency of cyclin-dependent kinase inhibitors. AAPS J. 2006 Mar 24;8(1):E204-21. | ||||
| REF 17 | Discovery of 1,4-dihydroindeno[1,2-c]pyrazoles as a novel class of potent and selective checkpoint kinase 1 inhibitors. Bioorg Med Chem. 2007 Apr 1;15(7):2759-67. | ||||
| REF 18 | Design, synthesis, and biological activity of 5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-one-based potent and selective Chk-1 inhibitors. J Med Chem. 2007 Aug 23;50(17):4162-76. | ||||
| REF 19 | Hit to lead optimization of pyrazolo[1,5-a]pyrimidines as B-Raf kinase inhibitors. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6890-2. | ||||
| REF 20 | Use of a pharmacophore model for the design of EGF-R tyrosine kinase inhibitors: 4-(phenylamino)pyrazolo[3,4-d]pyrimidines. J Med Chem. 1997 Oct 24;40(22):3601-16. | ||||
| REF 21 | Paullones, a series of cyclin-dependent kinase inhibitors: synthesis, evaluation of CDK1/cyclin B inhibition, and in vitro antitumor activity. J Med Chem. 1999 Jul 29;42(15):2909-19. | ||||
| REF 22 | Structure-based design of 2-arylamino-4-cyclohexylmethyl-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinases 1 and 2. Bioorg Med Chem Lett. 2003 Sep 15;13(18):3079-82. | ||||
| REF 23 | 2,6,8,9-tetrasubstituted purines as new CDK1 inhibitors. Bioorg Med Chem Lett. 2003 Sep 15;13(18):2993-6. | ||||
| REF 24 | Water-soluble isoindolo[2,1-a]quinoxalin-6-imines: in vitro antiproliferative activity and molecular mechanism(s) of action. Eur J Med Chem. 2015 Apr 13;94:149-62. | ||||
| REF 25 | 3D-QSAR CoMFA on cyclin-dependent kinase inhibitors. J Med Chem. 2000 Nov 2;43(22):4098-108. | ||||
| REF 26 | Structural classification of protein kinases using 3D molecular interaction field analysis of their ligand binding sites: target family landscapes. J Med Chem. 2002 Jun 6;45(12):2366-78. | ||||
| REF 27 | 7-[1H-Indol-2-yl]-2,3-dihydro-isoindol-1-ones as dual Aurora-A/VEGF-R2 kinase inhibitors: design, synthesis, and biological activity. Bioorg Med Chem Lett. 2008 Sep 15;18(18):5130-3. | ||||
| REF 28 | A novel 5-[1,3,4-oxadiazol-2-yl]-N-aryl-4,6-pyrimidine diamine having dual EGFR/HER2 kinase activity: design, synthesis, and biological activity. Bioorg Med Chem Lett. 2008 Sep 1;18(17):4896-9. | ||||
| REF 29 | Evidence for a new binding mode to GSK-3: allosteric regulation by the marine compound palinurin. Eur J Med Chem. 2013 Feb;60:479-89. | ||||
| REF 30 | Discovery of a Type III Inhibitor of LIM Kinase 2 That Binds in a DFG-Out Conformation. ACS Med Chem Lett. 2014 Aug 7;6(1):53-7 | ||||
| REF 31 | Identification of novel purine and pyrimidine cyclin-dependent kinase inhibitors with distinct molecular interactions and tumor cell growth inhibition profiles. J Med Chem. 2000 Jul 27;43(15):2797-804. | ||||
| REF 32 | Discovery of 3-alkoxyamino-5-(pyridin-2-ylamino)pyrazine-2-carbonitriles as selective, orally bioavailable CHK1 inhibitors. J Med Chem. 2012 Nov 26;55(22):10229-40. | ||||
| REF 33 | Docking-based development of purine-like inhibitors of cyclin-dependent kinase-2. J Med Chem. 2000 Jun 29;43(13):2506-13. | ||||
| REF 34 | A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20523-8. | ||||
| REF 35 | Structure-based design of novel Chk1 inhibitors: insights into hydrogen bonding and protein-ligand affinity. J Med Chem. 2005 Jun 30;48(13):4332-45. | ||||
| REF 36 | Alkyl and alkoxyethyl antineoplastic phospholipids. J Med Chem. 1996 Jun 21;39(13):2609-14. | ||||
| REF 37 | Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2). J Med Chem. 2007 May 31;50(11):2647-54. | ||||
| REF 38 | Benzo[c]quinoliziniums: A new family of inhibitors for protein kinase CK II. Bioorg Med Chem Lett. 1997 Apr 22;7(8):961-4. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.