Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T50773 | Target Info | |||
| Target Name | Dipeptidyl-peptidase 7 (DPP7) | ||||
| Synonyms |
Quiescent cell proline dipeptidase; QPP; Dipeptidyl peptidase II; Dipeptidyl peptidase 7; Dipeptidyl peptidase 2; Dipeptidyl aminopeptidase II; DPP2; DPP II
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| Target Type | Patented-recorded Target | ||||
| Gene Name | DPP7 | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 604 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Vildagliptin
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|
Approved | Compound Info | ||
| Synonyms |
Equa; Galvu; Galvus; Jalra; Xiliarx; Galvus (TN); Vidagliptin (see Vildagliptin); Vildagliptin (JAN/USAN/INN); (2S)-(((3-hydroxyadamantan-1-yl)amino)acetyl)pyrrolidine-2-carbonitrile; (2S)-1-[2-[(3-hydroxy-1-adamantyl)amino]acetyl]pyrrolidine-2-carbonitrile; 1-[2-[(3-hydroxy-1-adamantyl)amino]acetyl]pyrrolidine-2-carbonitrile; 2-Pyrrolidinecarbonitrile, 1-[[(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)amino]acetyl]-, (2S)-(9CI)
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Sitagliptin
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Approved | Compound Info | ||
| Synonyms |
486460-32-6; Januvia; Xelevia; Sitagliptan; MK-0431; UNII-QFP0P1DV7Z; Tesavel; QFP0P1DV7Z; (3R)-3-AMINO-1-[3-(TRIFLUOROMETHYL)-5H,6H,7H,8H-[1,2,4]TRIAZOLO[4,3-A]PYRAZIN-7-YL]-4-(2,4,5-TRIFLUOROPHENYL)BUTAN-1-ONE; (2R)-4-OXO-4-[3-(TRIFLUOROMETHYL)-5,6-DIHYDRO[1,2,4]TRIAZOLO[4,3-A]PYRAZIN-7(8H)-YL]-1-(2,4,5-TRIFLUOROPHENYL)BUTAN-2-AMINE; CHEBI:40237; (R)-3-AMINO-1-(3-(TRIFLUOROMETHYL)-5,6-DIHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZIN-7(8H)-YL)-4-(2,4,5-TRIFLUOROPHENYL)BUTAN-1-ONE; Janumet; Sitagliptin phosphate; Januvia (TN); Sitagliptin (PropINN); Januvia (merck & Co); (3R)-3-Amino-1-[3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one; (3R)-3-amino-1-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one; (3R)-3-amino-1-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one; Sitagliptin/atovastatin
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| Activity |
IC50 = 59830 nM
|
[2] | |||
| Compound Name |
Linagliptin
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Approved | Compound Info | ||
| Synonyms |
Ondero; BI 1356; BI-1356; Ondero (TN); BI-1356-BS; (R)-8-(3-Amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Alogliptin
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Approved | Compound Info | ||
| Synonyms |
850649-61-5; UNII-JHC049LO86; alogliptina; 2-({6-[(3r)-3-Aminopiperidin-1-Yl]-3-Methyl-2,4-Dioxo-3,4-Dihydropyrimidin-1(2h)-Yl}methyl)benzonitrile; SYR-322; JHC049LO86; (R)-2-((6-(3-aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile; CHEBI:72323; AK322010; 2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl}methyl)benzonitrile; vipidia; Alogliptin [INN]; Alogliptin (SYR-322); alogliptinum; alogliptine; HSDB 8203; UNII-JHC049LO86
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Anagliptin
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Approved | Compound Info | ||
| Synonyms |
Anagliptin; 739366-20-2; UNII-K726J96838; suiny; CHEMBL1929396; (S)-N-(2-((2-(2-Cyanopyrrolidin-1-yl)-2-oxoethyl)amino)-2-methylpropyl)-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide; K726J96838; CHEMBL1929387; N-[2-[[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]amino]-2-methylpropyl]-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide; Anagliptin [INN]; N-[2-({2-[(2s)-2-Cyanopyrrolidin-1-Yl]-2-Oxoethyl}amino)-2-Methylpropyl]-2-Methylpyrazolo[1,5-A]pyrimidine-6-Carboxamide; Anagliptin (JAN/INN); SCHEMBL905393; sk-0403
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| Activity |
IC50 = 176700 nM
|
[4] | |||
| Compound Name |
MK-3102
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Phase 3 | Compound Info | ||
| Synonyms |
Omarigliptin
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| Activity |
IC50 ~ 67000 nM
|
[5] | |||
| Compound Name |
NVP-DPP728
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Discontinued in Phase 2 | Compound Info | ||
| Synonyms |
NVP-DPP728; HCX5M1YIOM; UNII-HCX5M1YIOM; CHEMBL77538; NVP-DPP-728; NVP-728; 247016-69-9; dpp-728; BMCL15687 Compound 2; cyanopyrrolidine derivative 2; SCHEMBL160102; BDBM11113; cyano-(S)-pyrrolidine deriv. 1; ZINC26396245; AKOS030529265; LS-137333; (2S)-1-(2-((2-((5-Cyano-2-pyridyl)amino)ethyl)amino)acetyl)pyrrolidine-2-carbonitrile; 1-[[[2-[(5-cyanopyridin-2-yl)amino]ethyl]amino]acetyl]-2-cyano-(s)-pyrroli-dine; (S)-6-((2-((2-(2-cyanopyrrolidin-1-yl)-2-oxoethyl)amino)ethyl)amino)nicotinonitrile; 3-Pyridinecarbonitrile, 6-((2
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| Activity |
IC50 = 110000 nM
|
[6] | |||
| Compound Name |
1G244
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Investigative | Compound Info | ||
| Synonyms |
1G244; CHEMBL1814633; (2~{S})-2-azanyl-4-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-1-(1,3-dihydroisoindol-2-yl)butane-1,4-dione; GTPL8551; SCHEMBL19350285; C29H30N4O2F2; ZINC14949370; BDBM50350169; AKOS030528223; 847928-32-9; (S)-2-amino-4-(4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)-1-(isoindolin-2-yl)butane-1,4-dione; Y0432
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| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
N-isoleucylthiazolidine
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Investigative | Compound Info | ||
| Synonyms |
UNII-SDH8E9EM4L; SDH8E9EM4L; CHEMBL98408; 1-Pentanone, 2-amino-3-methyl-1-(3-thiazolidinyl)-, (2S,3S)-; thiazolidide 2; AC1OCFGU; 3-(L-Ile-)Thiazolidine; BMCL15687 Compound 4; (S)-Isoleucine Thiazolidide; SCHEMBL353709; BDBM11464; ZINC3931585
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| Activity |
IC50 = 68985 nM
|
[8] | |||
| Compound Name |
ARI-3099
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Investigative | Compound Info | ||
| Synonyms |
compound 6 [PMID: 23594271]; compound 226 [PMID: 24997602]; Py(D)AlaboroPro
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| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
Cyclohexylglycine-(2S)-cyanopyrrolidine
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Investigative | Compound Info | ||
| Synonyms |
Chg-Pro-CN; CHEMBL307636; cyclohexylglycine-(2S)-cyanopyrrolidine; BMCL15687 Compound 3; SCHEMBL14392566; BDBM11694; Cyclohexylglycine-(2S)-cyanopyrolidine 3; Cyclohexylglycine-(2S)-cyanopyrrolidine 2
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| Activity |
IC50 = 102000 nM
|
[6] | |||
| Compound Name |
(2S,3S)-2-Amino-1-(5-azidoisoindolin-2-yl)-3-methylpentan-1-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL487432; BDBM50243082
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| Activity |
IC50 ~ 50000 nM
|
[10] | |||
| Compound Name |
CID 44123747
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1819090; SCHEMBL162310; BDBM50351402
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| Activity |
IC50 ~ 50000 nM
|
[11] | |||
| Compound Name |
5-Cyano-N-[2-[(2S)-2-cyano-4,4-difluoropyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233845; BDBM50009374
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| Activity |
IC50 ~ 50000 nM
|
[9] | |||
| Compound Name |
(2S)-2-Amino-4-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]-1-(1,3-dihydroisoindol-2-yl)butane-1,4-dione;2,2,2-trifluoroacetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1814741
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| Activity |
IC50 ~ 50000 nM
|
[12] | |||
| Compound Name |
(2S)-2-Amino-4-[4-[bis(4-fluorophenyl)methyl]-3-oxopiperazin-1-yl]-1-(1,3-dihydroisoindol-2-yl)butane-1,4-dione;dihydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3216276
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| Activity |
IC50 ~ 50000 nM
|
[12] | |||
| Compound Name |
(6S)-1-[(2S)-2-Amino-4-oxo-4-[2-thiophen-2-yl-4-(trifluoromethyl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-7-yl]butyl]-5,5-difluoro-6-hydroxypiperidin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3644792; SCHEMBL13099364; BDBM97585; US8470836, 12
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| Activity |
IC50 ~ 50000 nM
|
[13] | |||
| Compound Name |
5-Bromo-N-[2-[(2S)-2-cyano-4,4-difluoropyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233844; SCHEMBL15129853; BDBM50009373
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| Activity |
IC50 ~ 50000 nM
|
[9] | |||
| Compound Name |
(S)-2-Amino-2-((1S,3R)-3-hydroxy-cyclopentyl)-1-pyrrolidin-1-yl-ethanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL355244; BDBM50141632
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| Activity |
IC50 = 50000 nM
|
[14] | |||
| Compound Name |
(2S)-2-Amino-4-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-1-(5-fluoro-1,3-dihydroisoindol-2-yl)butane-1,4-dione;2,2,2-trifluoroacetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1814739
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| Activity |
IC50 ~ 50000 nM
|
[12] | |||
| Compound Name |
(R)-3-Amino-4-(2-fluoro-phenyl)-1-((R)-2-isopropyl-piperazin-1-yl)-butan-1-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL360488; BDBM50151826
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| Activity |
IC50 = 50000 nM
|
[15] | |||
| Compound Name |
(3R,4R)-1-Pyridin-2-yl-4-(2,4,5-trifluorophenyl)piperidin-3-amine;2,2,2-trifluoroacetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL230340
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| Activity |
IC50 = 50000 nM
|
[16] | |||
| Compound Name |
(2S)-2-Amino-4-[(3S)-4-[bis(4-fluorophenyl)methyl]-3-methylpiperazin-1-yl]-1-(1,3-dihydroisoindol-2-yl)butane-1,4-dione;2,2,2-trifluoroacetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1814748
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| Activity |
IC50 ~ 50000 nM
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[12] | |||
| Compound Name |
(2S)-2-Amino-1-(1,3-dihydroisoindol-2-yl)-4-[4-(naphthalen-2-ylmethyl)piperazin-1-yl]butane-1,4-dione;dihydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3216066
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| Activity |
IC50 ~ 50000 nM
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[12] | |||
| Compound Name |
(2S)-1-(2-{[4-(6-Fluoro-1,2,3,4-tetrahydroisoquinolin-2-yl)-2-methyl-4-oxobutan-2-yl]amino}acetyl)pyrrolidine-2-carbonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL380902; BDBM11717; (2S)-Cyanopyrrolidine analogue 21b
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| Activity |
IC50 = 50146 nM
|
[8] | |||
| Compound Name |
(2S,4S)-1-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-4-fluoropyrrolidine-2-carbonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3330060; BDBM50098903
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| Activity |
IC50 = 50620 nM
|
[17] | |||
| Compound Name |
N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N-(4,4,4-trifluorobutyl)acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683112; BDBM50338405; trans-N-(4-((R)-1-amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)-N-(4,4,4-trifluorobutyl)acetamide
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| Activity |
IC50 = 51000 nM
|
[18] | |||
| Compound Name |
Thiazolopiperidine 76
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL196881; SCHEMBL8312000; BDBM11974
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| Activity |
IC50 = 51000 nM
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[19] | |||
| Compound Name |
(3R)-3-Amino-4-(2,5-difluorophenyl)-1-[2-methyl-3-(trifluoromethyl)-2H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridin-5-yl]butan-1-one
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Investigative | Compound Info | ||
| Synonyms |
pyrazolopiperidine 48; CHEMBL191805; BDBM11946
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| Activity |
IC50 = 51000 nM
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[19] | |||
| Compound Name |
2,6-Diamino-1-azepan-1-yl-hexan-1-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL149498; BDBM50135082
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| Activity |
IC50 = 51900 nM
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[20] | |||
| Compound Name |
2-[(2H-1,3-Benzodioxol-5-ylmethyl)amino]-1-(piperidin-1-yl)ethan-1-one
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Investigative | Compound Info | ||
| Synonyms |
Amide Analogue 36; CHEMBL368869; BDBM12454; 15.2c; AKOS009030308; N-(1,3-benzodioxol-5-ylmethyl)-N-(2-oxo-2-piperidin-1-ylethyl)amine
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| Activity |
IC50 = 52000 nM
|
[21] | |||
| Compound Name |
1-Isoleucyl-1,2,5,6-tetrahydropyridine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL452470; BDBM50243552; (2S,3S)-2-amino-1-(5,6-dihydropyridin-1(2H)-yl)-3-methylpentan-1-one
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| Activity |
IC50 = 52000 nM
|
[22] | |||
| Compound Name |
(R)-2-(2,5-Difluorophenyl)-1-(1-(6-fluoropyridin-3-yl)piperidin-4-yl)ethanamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683136; BDBM50338430
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| Activity |
IC50 = 52000 nM
|
[18] | |||
| Compound Name |
(3R)-3-Amino-1-[8-benzyl-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL539350
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| Activity |
IC50 = 52000 nM
|
[23] | |||
| Compound Name |
2-Amino-1-(3,6-dihydro-2H-pyridin-1-yl)-3-methyl-pentan-1-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL444537; BDBM50135047
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| Activity |
IC50 = 52000 nM
|
[20] | |||
| Compound Name |
(2-Cyclopentylidene-2-fluoroethyl)[3-(dimethylamino)propyl]amine
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Investigative | Compound Info | ||
| Synonyms |
Fluoro-Olefin Analogue 8; CHEMBL179028; BDBM12426; 9.7h; N-(2-Cyclopentylidene-2-fluoroethyl)-N3,N3-dimethyl-1,3-propanediamine
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| Activity |
IC50 = 53700 nM
|
[21] | |||
| Compound Name |
(R)-3-Amino-1-(2-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL399499; SCHEMBL5228197; BDBM50221447
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| Activity |
IC50 = 54000 nM
|
[24] | |||
| Compound Name |
(3R,4R)-1-Pyrimidin-2-yl-4-(2,4,5-trifluorophenyl)piperidin-3-amine;2,2,2-trifluoroacetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL427259
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| Activity |
IC50 = 54000 nM
|
[16] | |||
| Compound Name |
(3R)-3-Amino-4-(2,5-difluorophenyl)-1-[3-(trifluoromethyl)-4H,5H,6H,7H-pyrido[4,3-c][1,2]oxazol-5-yl]butan-1-one
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Investigative | Compound Info | ||
| Synonyms |
isoxazolopiperidine 59; CHEMBL363606; BDBM11957
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| Activity |
IC50 = 54000 nM
|
[19] | |||
| Compound Name |
cis-1-(4-((R)-1-Amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)piperidine-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683118; CHEMBL1683119; BDBM50338412; BDBM50338413; trans-1-(4-((R)-1-amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)piperidine-3-carboxamide
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| Activity |
IC50 = 54000 nM
|
[18] | |||
| Compound Name |
N-[(2R,3R)-2-Amino-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-7-yl]acetamide;2,2,2-trifluoroacetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL556494
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| Activity |
IC50 = 54000 nM
|
[25] | |||
| Compound Name |
(2-Cyclohexylidene-2-fluoroethyl)[3-(dimethylamino)propyl]amine
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Investigative | Compound Info | ||
| Synonyms |
Fluoro-Olefin Analogue 21; CHEMBL175988; BDBM12439; 9.8m; N-(2-Cyclohexylidene-2-fluoroethyl)-N3,N3-dimethyl-1,3-propanediamine
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| Activity |
IC50 = 54600 nM
|
[21] | |||
| Compound Name |
(2S,3S)-3-Amino-N-cyclopropyl-2-[4-(4-fluorophenyl)phenyl]-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutanamide;2,2,2-trifluoroacetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL190788
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| Activity |
IC50 = 55000 nM
|
[26] | |||
| Compound Name |
(2S)-1-[3-Amino-4-(2-fluorophenyl)butanoyl]-N-[[4-(trifluoromethyl)phenyl]methyl]pyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL435882
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| Activity |
IC50 = 55000 nM
|
[27] | |||
| Compound Name |
N-Benzyl-2-(1-pyrrolidinyl)ethanamine
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Investigative | Compound Info | ||
| Synonyms |
N-benzyl-2-(pyrrolidin-1-yl)ethanamine; N-benzyl-2-pyrrolidin-1-ylethanamine; CHEMBL175708; SCHEMBL5756091; CTK5C3211; DTXSID30391413; STK124718; ZINC20126974; AKOS008994457; benzyl[2-(pyrrolidin-1-yl)ethyl]amine; MCULE-4281028842; NCGC00341278-01; EC-000.1340; AB01333066-02; Z86205465
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| Activity |
IC50 = 55300 nM
|
[21] | |||
| Compound Name |
(R)-3-Amino-4-(2,5-difluoro-phenyl)-1-[3-(4-fluoro-benzyl)-2-trifluoromethyl-1,4,6,7-tetrahydro-imidazo[4,5-c]pyridin-5-yl]-butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL400761; BDBM50222479
Click to Show/Hide
|
||||
| Activity |
IC50 = 56000 nM
|
[28] | |||
| Compound Name |
(2R,3S,5R)-5-(2-Cyclopentylsulfonyl-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl)-2-(2,5-difluorophenyl)oxan-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3736085; SCHEMBL14845416
Click to Show/Hide
|
||||
| Activity |
IC50 = 56000 nM
|
[29] | |||
| Compound Name |
(3R)-3-Amino-1-{2-cyclopropyl-4H,5H,6H,7H-pyrido[4,3-d][1,3]oxazol-5-yl}-4-(2,5-difluorophenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
oxazolopiperidine 72; CHEMBL425380; BDBM11970
Click to Show/Hide
|
||||
| Activity |
IC50 = 56000 nM
|
[19] | |||
| Compound Name |
(3R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-methyl-1-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
1-substituted diazepanone 9h; CHEMBL390886; BDBM15537
Click to Show/Hide
|
||||
| Activity |
IC50 = 56000 nM
|
[30] | |||
| Compound Name |
(R)-3-Amino-4-(2,4-difluoro-phenyl)-1-thiazolidin-3-yl-butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL184912; BDBM50151793
Click to Show/Hide
|
||||
| Activity |
IC50 = 56050 nM
|
[31] | |||
| Compound Name |
(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxo-2-[4-(3-pyridin-1-ium-1-ylphenyl)phenyl]butanamide;2,2,2-trifluoroacetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL541919
Click to Show/Hide
|
||||
| Activity |
IC50 = 57000 nM
|
[26] | |||
| Compound Name |
(2S,3S)-3-Amino-2-[4-(3-cyanophenyl)phenyl]-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL190269
Click to Show/Hide
|
||||
| Activity |
IC50 = 57000 nM
|
[26] | |||
| Compound Name |
N-[5-[(3R,5S,6R)-5-Amino-6-(2,5-difluorophenyl)oxan-3-yl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]ethanesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3734828; BDBM50134192
Click to Show/Hide
|
||||
| Activity |
IC50 = 57000 nM
|
[29] | |||
| Compound Name |
N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N,5-dimethyl-1H-pyrazole-4-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683086; BDBM50338452
Click to Show/Hide
|
||||
| Activity |
IC50 = 57000 nM
|
[18] | |||
| Compound Name |
2,2,2-Trifluoroacetic acid;(3R,4R)-1-[3-(trifluoromethyl)pyridin-2-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL230449
Click to Show/Hide
|
||||
| Activity |
IC50 = 57000 nM
|
[16] | |||
| Compound Name |
(3R)-3-Amino-1-[8-[(4-methoxyphenyl)methyl]-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL539352
Click to Show/Hide
|
||||
| Activity |
IC50 = 57000 nM
|
[23] | |||
| Compound Name |
6-[(3R,4R)-3-Amino-4-(2,4,5-trifluorophenyl)piperidin-1-yl]-2-methyl-[1,2,4]triazolo[4,3-b]pyridazin-3-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL390241
Click to Show/Hide
|
||||
| Activity |
IC50 = 57000 nM
|
[16] | |||
| Compound Name |
2-Amino-1-piperidin-1-yl-pentan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL146190; BDBM50135060; 2-amino-1-piperidin-1-ylpentan-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 57100 nM
|
[20] | |||
| Compound Name |
3-[2-(2-Cyano-(S)-pyrrolidin-1-yl)-2-oxoethylamino]-N-phenylpropionamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL371480; BDBM11712; (2S)-Cyanopyrrolidine analogue 18p; 3-({2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl}amino)-N-phenylpropanamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 57176 nM
|
[8] | |||
| Compound Name |
(3R,4R)-1-Pyrido[2,3-b]pyrazin-3-yl-4-(2,4,5-trifluorophenyl)piperidin-3-amine;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL231194
Click to Show/Hide
|
||||
| Activity |
IC50 = 58000 nM
|
[16] | |||
| Compound Name |
(R)-3-Amino-4-(2,5-difluorophenyl)-1-(2-(4-fluorophenyl)-1-methyl-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL398661; BDBM50222482
Click to Show/Hide
|
||||
| Activity |
IC50 = 58000 nM
|
[28] | |||
| Compound Name |
N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N-methyl-1,2-oxazole-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683106; BDBM50338472; trans-N-(4-((R)-1-amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)-N-methylisoxazole-5-carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 58000 nM
|
[18] | |||
| Compound Name |
(2S,3S)-3-Amino-4-(3-fluoroazetidin-1-yl)-2-[4-(4-fluorophenyl)phenyl]-N,N-dimethyl-4-oxobutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL363115
Click to Show/Hide
|
||||
| Activity |
IC50 = 58000 nM
|
[26] | |||
| Compound Name |
N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N-methylpyridine-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683104; BDBM50338470; trans-N-(4-((R)-1-amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)-N-methylnicotinamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 58000 nM
|
[18] | |||
| Compound Name |
(3r)-4-[(3r)-3-Amino-4-(2,4,5-Trifluorophenyl)butanoyl]-3-(2,2,2-Trifluoroethyl)-1,4-Diazepan-2-One
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Diazepanone Analog 1; SCHEMBL388929; CHEMBL217271; BDBM13525; Q27096498
Click to Show/Hide
|
||||
| Activity |
IC50 = 59000 nM
|
[32] | |||
| Compound Name |
1-Pentanone, 2-amino-3-methyl-1-(1-piperidinyl)-, (2S,3S)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL83418; 1-(L-Ile-)Piperidine; SCHEMBL16578291; BDBM50243497; ZINC11959236; (2S,3S)-2-amino-3-methyl-1-(piperidin-1-yl)pentan-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 59000 nM
|
[22] | |||
| Compound Name |
(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-phenylbutan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL362973
Click to Show/Hide
|
||||
| Activity |
IC50 = 59000 nM
|
[33] | |||
| Compound Name |
3-Methyl-1-oxo-1-piperidin-1-ylpentan-2-aminium
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL93507; SCHEMBL6824150; BDBM50118936; AKOS000171918; 2-Amino-3-methyl-1-piperidin-1-yl-pentan-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 59000 nM
|
[20] | |||
| Compound Name |
4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-methyl-1,4-diazepan-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL390853
Click to Show/Hide
|
||||
| Activity |
IC50 = 59000 nM
|
[30] | |||
| Compound Name |
(3R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-methyl-1,4-diazepan-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
1,4-diazepan-2-one 2b; Diazepanone Analog 18; CHEMBL385711; SCHEMBL1394444; BDBM13519; (R,R); DB07154; Q27096070
Click to Show/Hide
|
||||
| Activity |
IC50 = 59000 nM
|
[32] | |||
| Compound Name |
Methyl 2-[4-[[[(4R)-3-[3-amino-4-(2-fluorophenyl)butanoyl]-1,3-thiazolidine-4-carbonyl]amino]methyl]phenyl]acetate;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL186482
Click to Show/Hide
|
||||
| Activity |
IC50 = 59000 nM
|
[27] | |||
| Compound Name |
(2S,4S)-1-[(3R)-3-Amino-4-(3-fluorophenyl)butanoyl]-4-fluoropyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3330052; BDBM50098909
Click to Show/Hide
|
||||
| Activity |
IC50 = 59100 nM
|
[17] | |||
| Compound Name |
(3R)-3-Amino-1-[8-(2,2,2-trifluoroethyl)-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL536999
Click to Show/Hide
|
||||
| Activity |
IC50 = 60000 nM
|
[23] | |||
| Compound Name |
(S)-1-(2-(2-Tert-butyl-1,3,4-oxadiazole-5-carbonyl)pyrrolidin-1-yl)-2-(1-hydroxy-2-methylpropan-2-ylamino)ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL232759; BDBM50214712
Click to Show/Hide
|
||||
| Activity |
IC50 = 60000 nM
|
[34] | |||
| Compound Name |
(2S)-2-Amino-1-(2-diphenoxyphosphorylpyrrolidin-1-yl)-3-(1H-imidazol-4-yl)propan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL236602; Compound 10.5; BDBM98045
Click to Show/Hide
|
||||
| Activity |
IC50 = 60000 nM
|
[35] | |||
| Compound Name |
(R)-1-((R)-8-(4-Fluorobenzyl)-2-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-3-amino-4-(2,4,5-trifluorophenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL401304; BDBM50221452
Click to Show/Hide
|
||||
| Activity |
IC50 = 60000 nM
|
[24] | |||
| Compound Name |
(S)-2-Amino-1-(pyrrolidin-1-yl)hexan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL442952; BDBM50243495
Click to Show/Hide
|
||||
| Activity |
IC50 = 60000 nM
|
[22] | |||
| Compound Name |
(2R,3S,5R)-2-(2,5-Difluorophenyl)-5-[2-(1-methylimidazol-4-yl)sulfonyl-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl]oxan-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3736423; BDBM50135009
Click to Show/Hide
|
||||
| Activity |
IC50 = 61000 nM
|
[29] | |||
| Compound Name |
(3R,6S)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-ethyl-6-methyl-1,4-diazepan-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
6-methyl diazepanone 14c; CHEMBL230388; BDBM15547
Click to Show/Hide
|
||||
| Activity |
IC50 = 61000 nM
|
[30] | |||
| Compound Name |
(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-[4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]butanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL209064
Click to Show/Hide
|
||||
| Activity |
IC50 = 61000 nM
|
[36] | |||
| Compound Name |
(1S,2R,5S)-5-(2-Cyclopropyl-5H-pyrrolo[3,4-d]pyrimidin-6(7H)-yl)-2-(2,4,5-trifluorophenyl)cyclohexanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL233563; SCHEMBL1528614; BDBM50212928
Click to Show/Hide
|
||||
| Activity |
IC50 = 61000 nM
|
[37] | |||
| Compound Name |
N-(2-Cyclopentylideneethyl)cyclohexanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Olefin Analogue 22; CHEMBL176121; BDBM12440; 10.7a; ZINC13611607
Click to Show/Hide
|
||||
| Activity |
IC50 = 62000 nM
|
[21] | |||
| Compound Name |
(S)-2-Amino-2-((1S,3R)-3-methoxy-cyclohexyl)-1-pyrrolidin-1-yl-ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL352632; BDBM50141646
Click to Show/Hide
|
||||
| Activity |
IC50 = 62000 nM
|
[14] | |||
| Compound Name |
(3R)-3-Amino-1-[8-prop-2-enyl-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL537000
Click to Show/Hide
|
||||
| Activity |
IC50 = 62000 nM
|
[23] | |||
| Compound Name |
2-Amino-3-hydroxy-1-piperidin-1-yl-propan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL146995; SCHEMBL6820648; BDBM50135069
Click to Show/Hide
|
||||
| Activity |
IC50 = 62000 nM
|
[20] | |||
| Compound Name |
(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxo-2-(4-pyrazolo[1,5-a]pyrimidin-5-ylphenyl)butanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL210459
Click to Show/Hide
|
||||
| Activity |
IC50 = 63000 nM
|
[36] | |||
| Compound Name |
2-[(2H-1,3-Benzodioxol-5-ylmethyl)amino]-1-(pyrrolidin-1-yl)ethan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
15.1c; Amide Analogue 27; CHEMBL177644; BDBM12445; AKOS009030269; N-(1,3-benzodioxol-5-ylmethyl)-N-(2-oxo-2-pyrrolidin-1-ylethyl)amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 63000 nM
|
[21] | |||
| Compound Name |
N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N,3,5-trimethyl-1,2-oxazole-4-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683091; BDBM50338457
Click to Show/Hide
|
||||
| Activity |
IC50 = 63000 nM
|
[18] | |||
| Compound Name |
(3R)-3-Amino-4-(2,5-difluorophenyl)-1-[2-(trifluoromethyl)-4H,5H,6H,7H-pyrido[4,3-d][1,3]thiazol-5-yl]butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
thiazolopiperidine 67; CHEMBL426649; BDBM11965
Click to Show/Hide
|
||||
| Activity |
IC50 = 63000 nM
|
[19] | |||
| Compound Name |
(R)-1-(1-(4-Fluorobenzyl)-2-(trifluoromethyl)-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)-3-amino-4-(2,5-difluorophenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL248788; BDBM50222483
Click to Show/Hide
|
||||
| Activity |
IC50 = 64000 nM
|
[28] | |||
| Compound Name |
(3R)-3-Amino-4-(3,4-difluorophenyl)-1-(3-ethyl-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL537844
Click to Show/Hide
|
||||
| Activity |
IC50 = 64000 nM
|
[38] | |||
| Compound Name |
2,2,2-Trifluoroacetic acid;(3R,4R)-1-[2-(trifluoromethyl)imidazo[1,2-b]pyridazin-6-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL389803
Click to Show/Hide
|
||||
| Activity |
IC50 = 64000 nM
|
[16] | |||
| Compound Name |
(R)-2-(2,5-Difluorophenyl)-1-(1-(methylsulfonyl)piperidin-4-yl)ethanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683130; BDBM50338424
Click to Show/Hide
|
||||
| Activity |
IC50 = 65000 nM
|
[18] | |||
| Compound Name |
(S)-2-Amino-3-hydroxy-1-(pyrrolidin-1-yl)propan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL459641; BDBM50243455; (2S)-1-Pyrrolizino-2-amino-3-hydroxy-1-propanone; (2S)-2-amino-3-hydroxy-1-pyrrolidin-1-ylpropan-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 65000 nM
|
[22] | |||
| Compound Name |
(2R,3S,5R)-5-(3H-1,2-Benzoxazol-2-yl)-2-(2,5-difluorophenyl)oxan-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2425067; BDBM50440346
Click to Show/Hide
|
||||
| Activity |
IC50 = 65000 nM
|
[39] | |||
| Compound Name |
2-Amino-3-hydroxy-1-pyrrolidin-1-yl-propan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL97064; CTK8I9631; BDBM50118949
Click to Show/Hide
|
||||
| Activity |
IC50 = 65000 nM
|
[20] | |||
| Compound Name |
(R)-3-Amino-1-((R)-2-benzyl-piperazin-1-yl)-4-(2,5-difluoro-phenyl)-butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL369738; BDBM50151844
Click to Show/Hide
|
||||
| Activity |
IC50 = 65000 nM
|
[15] | |||
| Compound Name |
2-{(R)-4-[(R)-3-Amino-4-(2-fluoro-phenyl)-butyryl]-3-benzyl-piperazin-1-yl}-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL185067; SCHEMBL5419540; BDBM50151835; 2-[(3R)-4-[(3R)-3-amino-4-(2-fluorophenyl)butanoyl]-3-benzylpiperazin-1-yl]acetamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 66000 nM
|
[15] | |||
| Compound Name |
(2S,3S)-2-Amino-3-methyl-1-(5-nitroisoindolin-2-yl)pentan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL510322; BDBM50243081
Click to Show/Hide
|
||||
| Activity |
IC50 = 66000 nM
|
[10] | |||
| Compound Name |
(R)-1-(4-(1-Amino-2-(2,5-difluorophenyl)ethyl)piperidin-1-yl)ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683129; BDBM50338423
Click to Show/Hide
|
||||
| Activity |
IC50 = 66000 nM
|
[18] | |||
| Compound Name |
2-(1,3-Benzodioxol-5-ylmethylamino)-1-cyclopentylethanethione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL178433
Click to Show/Hide
|
||||
| Activity |
IC50 = 67000 nM
|
[21] | |||
| Compound Name |
(3R)-3-Amino-4-(2,5-difluorophenyl)-1-[3-(1,1,2,2,2-pentafluoroethyl)-1H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridin-5-yl]butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
pyrazolopiperidine 53; CHEMBL370269; BDBM11951
Click to Show/Hide
|
||||
| Activity |
IC50 = 67000 nM
|
[19] | |||
| Compound Name |
(3R)-3-Amino-4-(2,5-difluorophenyl)-1-[1-methyl-3-(trifluoromethyl)-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-6-yl]butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
pyrazolopiperidine 61; CHEMBL196938; BDBM11959
Click to Show/Hide
|
||||
| Activity |
IC50 = 67000 nM
|
[19] | |||
| Compound Name |
(R)-3-Amino-4-(4-fluoro-phenyl)-1-thiazolidin-3-yl-butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL363879; BDBM50151791
Click to Show/Hide
|
||||
| Activity |
IC50 = 67630 nM
|
[31] | |||
| Compound Name |
trans-N-(4-((R)-1-Amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)-N-ethylmethanesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683095; BDBM50338461
Click to Show/Hide
|
||||
| Activity |
IC50 = 68000 nM
|
[18] | |||
| Compound Name |
(1S,2R,5S)-5-(Isoindolin-2-yl)-2-(2,4,5-trifluorophenyl)cyclohexanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL392924; SCHEMBL14845909; BDBM50212926
Click to Show/Hide
|
||||
| Activity |
IC50 = 68000 nM
|
[37] | |||
| Compound Name |
Thioamide Analogue 38
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL175977; BDBM12456; 16.2a; ZINC13611638; N-Cyclohexyl-2-thioxo-2-(1-piperidinyl)ethaneamine; N-[2-(piperidin-1-yl)-2-sulfanylideneethyl]cyclohexanamine
Click to Show/Hide
|
||||
| Activity |
IC50 = 69000 nM
|
[21] | |||
| Compound Name |
N-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]acetamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL245971
Click to Show/Hide
|
||||
| Activity |
IC50 = 70000 nM
|
[40] | |||
| Compound Name |
(2R,3S,5R)-2-(2,4-Difluorophenyl)-5-(4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2425072; BDBM50440342
Click to Show/Hide
|
||||
| Activity |
IC50 = 70000 nM
|
[39] | |||
| Compound Name |
N-[5-[(3R,5S,6R)-5-Amino-6-(2,5-difluorophenyl)oxan-3-yl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]-1,3-thiazole-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3735129; BDBM50134189
Click to Show/Hide
|
||||
| Activity |
IC50 = 70000 nM
|
[29] | |||
| Compound Name |
1-((2S,4S)-2-(5-Tert-butyl-1,2,4-oxadiazole-3-carbonyl)-4-fluoropyrrolidin-1-yl)-2-(1-hydroxy-2-methylpropan-2-ylamino)ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL391929; BDBM50214724
Click to Show/Hide
|
||||
| Activity |
IC50 = 70100 nM
|
[34] | |||
| Compound Name |
(3R)-3-Amino-4-(2,5-difluorophenyl)-1-[3-(trifluoromethyl)-1H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridin-5-yl]butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
pyrazolopiperidine 46; CHEMBL197413; BDBM11944
Click to Show/Hide
|
||||
| Activity |
IC50 = 71000 nM
|
[19] | |||
| Compound Name |
(3R,6R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3,6-dimethyl-1,4-diazepan-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
6-methyl diazepanone 14b; CHEMBL397241; BDBM15544
Click to Show/Hide
|
||||
| Activity |
IC50 = 71000 nM
|
[30] | |||
| Compound Name |
(3R)-3-Amino-4-(2,5-difluorophenyl)-1-{3-methyl-1H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridin-5-yl}butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
pyrazolopiperidine 45; CHEMBL426469; BDBM11943
Click to Show/Hide
|
||||
| Activity |
IC50 = 71000 nM
|
[19] | |||
| Compound Name |
(2S,3As,6aS)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3,3a,4,5,6,6a-hexahydro-2H-cyclopenta[b]pyrrole-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3330073; BDBM50098911
Click to Show/Hide
|
||||
| Activity |
IC50 = 71680 nM
|
[17] | |||
| Compound Name |
(R)-3-Amino-1-((S)-8-methyl-2-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL251376; BDBM50221455
Click to Show/Hide
|
||||
| Activity |
IC50 = 72000 nM
|
[24] | |||
| Compound Name |
(3R)-3-Amino-1-(2-benzoyldiazinan-1-yl)-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL535180
Click to Show/Hide
|
||||
| Activity |
IC50 = 72000 nM
|
[41] | |||
| Compound Name |
trans-(R)-1-(4-((R)-1-Amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)piperidin-3-yl carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683122; BDBM50338416
Click to Show/Hide
|
||||
| Activity |
IC50 = 72000 nM
|
[18] | |||
| Compound Name |
(2R,3R)-7-Methoxy-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-2-amine;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL550598
Click to Show/Hide
|
||||
| Activity |
IC50 = 73000 nM
|
[25] | |||
| Compound Name |
(3R,7S)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3,7-dimethyl-1,4-diazepan-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
7-methyl diazepanone 15b; CHEMBL394836; BDBM15546
Click to Show/Hide
|
||||
| Activity |
IC50 = 73000 nM
|
[30] | |||
| Compound Name |
(3R,4R)-1-(3-Methyl-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-amine;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL231497
Click to Show/Hide
|
||||
| Activity |
IC50 = 74000 nM
|
[16] | |||
| Compound Name |
(3R)-3-Amino-1-[(6S)-6-methyl-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL557990
Click to Show/Hide
|
||||
| Activity |
IC50 = 74000 nM
|
[23] | |||
| Compound Name |
N-[(2R,3R)-2-Amino-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-7-yl]methanesulfonamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL561793
Click to Show/Hide
|
||||
| Activity |
IC50 = 74000 nM
|
[25] | |||
| Compound Name |
(2S,3S)-3-Amino-4-(1,1-dioxo-1,3-thiazolidin-3-yl)-2-[4-(4-fluorophenyl)phenyl]-N,N-dimethyl-4-oxobutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL365967
Click to Show/Hide
|
||||
| Activity |
IC50 = 75000 nM
|
[26] | |||
| Compound Name |
(3R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(pyrazin-2-ylmethyl)-1,4-diazepan-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL217702
Click to Show/Hide
|
||||
| Activity |
IC50 = 75000 nM
|
[32] | |||
| Compound Name |
(R)-3-Amino-4-(2,5-difluorophenyl)-1-(3-ethyl-2-(trifluoromethyl)-6,7-dihydro-3H-imidazo[4,5-c]pyridin-5(4H)-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL398492; BDBM50222488
Click to Show/Hide
|
||||
| Activity |
IC50 = 76000 nM
|
[28] | |||
| Compound Name |
(3R)-3-Amino-1-(1-methyl-4-(trifluoromethyl)-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL400954; BDBM50222477
Click to Show/Hide
|
||||
| Activity |
IC50 = 76000 nM
|
[28] | |||
| Compound Name |
(2S,3S)-3-Amino-2-[4-(4-fluorophenyl)phenyl]-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxo-N-propan-2-ylbutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL188643
Click to Show/Hide
|
||||
| Activity |
IC50 = 76000 nM
|
[26] | |||
| Compound Name |
(3R)-3-Amino-1-[8-[(2-fluorophenyl)methyl]-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL540888
Click to Show/Hide
|
||||
| Activity |
IC50 = 76000 nM
|
[23] | |||
| Compound Name |
(2S,3S)-3-Amino-2-[4-(4-fluorophenyl)phenyl]-N,N-dimethyl-4-morpholin-4-yl-4-oxobutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL371347
Click to Show/Hide
|
||||
| Activity |
IC50 = 77000 nM
|
[26] | |||
| Compound Name |
cis-(R)-2-(2,5-Difluorophenyl)-1-(4-(piperidin-1-yl)cyclohexyl)ethanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683116; CHEMBL1683117; BDBM50338410; BDBM50338411; trans-(R)-2-(2,5-difluorophenyl)-1-(4-(piperidin-1-yl)cyclohexyl)ethanamine
Click to Show/Hide
|
||||
| Activity |
IC50 = 77000 nM
|
[18] | |||
| Compound Name |
Benzyl (S)-1-(2-((bis(4-acetamidophenoxy))phosphoryl)pyrrolidin-1-yl)-6-amino-1-oxohexan-2-ylcarbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL238114; BDBM50225434
Click to Show/Hide
|
||||
| Activity |
IC50 = 77000 nM
|
[35] | |||
| Compound Name |
2,2,2-Trifluoroacetic acid;(3R,4R)-1-[4-(trifluoromethyl)pyridin-2-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL389602
Click to Show/Hide
|
||||
| Activity |
IC50 = 77000 nM
|
[16] | |||
| Compound Name |
(3R)-3-Amino-1-[5,5-dimethyl-3-(trifluoromethyl)-6,8-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL536765
Click to Show/Hide
|
||||
| Activity |
IC50 = 77000 nM
|
[23] | |||
| Compound Name |
(2S,3As,6aS)-1-[(3R)-3-amino-4-(4-fluorophenyl)butanoyl]-3,3a,4,5,6,6a-hexahydro-2H-cyclopenta[b]pyrrole-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3330066; BDBM50098989
Click to Show/Hide
|
||||
| Activity |
IC50 = 77030 nM
|
[17] | |||
| Compound Name |
(R)-3-Amino-4-(2,5-difluorophenyl)-1-(thiazolidin-3-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL433572; BDBM50151804; (R)-3-Amino-4-(2,5-difluoro-phenyl)-1-thiazolidin-3-yl-butan-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 77560 nM
|
[31] | |||
| Compound Name |
(R)-3-Amino-1-((R)-2-benzyl-piperazin-1-yl)-4-(2,4,5-trifluoro-phenyl)-butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL184636; BDBM50151840
Click to Show/Hide
|
||||
| Activity |
IC50 = 78000 nM
|
[15] | |||
| Compound Name |
(3R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-1-(2-hydroxyethyl)-3-methyl-1,4-diazepan-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
1-substituted diazepanone 9f; CHEMBL231117; BDBM15535
Click to Show/Hide
|
||||
| Activity |
IC50 = 78000 nM
|
[30] | |||
| Compound Name |
(3R)-3-Amino-1-[3-(1,1,2,2,2-pentafluoroethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL558585
Click to Show/Hide
|
||||
| Activity |
IC50 = 78000 nM
|
[38] | |||
| Compound Name |
Benzoic acid 1-(2,6-diamino-hexanoyl)-pyrrolidin-3-yl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL145855; BDBM50135066
Click to Show/Hide
|
||||
| Activity |
IC50 = 78100 nM
|
[20] | |||
| Compound Name |
2-Amino-1-(2-diphenoxyphosphorylpyrrolidin-1-yl)ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL399189; Compound 10.4; BDBM98044
Click to Show/Hide
|
||||
| Activity |
IC50 = 79000 nM
|
[35] | |||
| Compound Name |
Pyrrolidine, 1-(N-phenylalanyl)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
H-PHE-PYRROLIDIDE; L-Phenylalanine pyrrolidide; 1-[(2S)-2-AMINO-1-OXO-3-PHENYLPROPYL]PYRROLIDINE; (S)-2-amino-3-phenyl-1-(pyrrolidin-1-yl)propan-1-one; (2S)-2-amino-3-phenyl-1-pyrrolidin-1-ylpropan-1-one; CHEMBL453918; FC 191; 1-(N-Phenylalanyl)pyrrolidine; BRN 0010916; 1-(L-Phe-)Pyrrolidine; (S)-1-(2-Amino-1-oxo-3-phenylpropyl)pyrrolidine; H-Phe-Pyrrolidide, AldrichCPR; SCHEMBL1619160; (2S)-2-Amino-3-phenyl-1-(1-pyrrolidinyl)-1-propanone; CTK8F3041; DTXSID10238832; ZINC2567636; 7223AH; BDBM50243410; MFCD00672358; AKOS010390661; AS-46927; K-9988
Click to Show/Hide
|
||||
| Activity |
IC50 = 79000 nM
|
[22] | |||
| Compound Name |
2-Amino-3-phenyl-1-(pyrrolidin-1-yl)propan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL93931; 2-amino-3-phenyl-1-pyrrolidin-1-ylpropan-1-one; SCHEMBL1040335; BDBM50118939; AKOS000171590; AKOS016049949; MCULE-2792256444; 1-Pyrrolizino-2-amino-3-phenyl-1-propanone; FT-0661977; EN300-61595; 2-Amino-3-phenyl-1-pyrrolidin-1-yl-propan-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 79000 nM
|
[20] | |||
| Compound Name |
(2S,3S)-3-Amino-2-[4-(benzenesulfonamido)phenyl]-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL245772
Click to Show/Hide
|
||||
| Activity |
IC50 = 80000 nM
|
[40] | |||
| Compound Name |
(R)-3-Amino-4-(2,5-difluorophenyl)-1-(3-methyl-2-(trifluoromethyl)-6,7-dihydro-3H-imidazo[4,5-c]pyridin-5(4H)-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL251404; BDBM50222487
Click to Show/Hide
|
||||
| Activity |
IC50 = 80000 nM
|
[28] | |||
| Compound Name |
trans-(S)-1-(4-((R)-1-Amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)piperidine-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683120; BDBM50338414
Click to Show/Hide
|
||||
| Activity |
IC50 = 80000 nM
|
[18] | |||
| Compound Name |
(3R)-3-Amino-4-(2,5-difluorophenyl)-1-{2-methyl-4H,5H,6H,7H-pyrido[4,3-d][1,3]thiazol-5-yl}butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
thiazolopiperidine 66; CHEMBL196333; BDBM11964
Click to Show/Hide
|
||||
| Activity |
IC50 = 80000 nM
|
[19] | |||
| Compound Name |
trans-N-(4-((R)-1-Amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)-N-methylpivalamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683101; BDBM50338467
Click to Show/Hide
|
||||
| Activity |
IC50 = 81000 nM
|
[18] | |||
| Compound Name |
(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-2-[4-(3-methylsulfonylphenyl)phenyl]-4-oxobutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL370677
Click to Show/Hide
|
||||
| Activity |
IC50 = 81000 nM
|
[26] | |||
| Compound Name |
(3R,4R)-1-Pyridin-3-yl-4-(2,4,5-trifluorophenyl)piperidin-3-amine;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL230341
Click to Show/Hide
|
||||
| Activity |
IC50 = 82000 nM
|
[16] | |||
| Compound Name |
(R)-3-Amino-1-thiazolidin-3-yl-4-(2-trifluoromethyl-phenyl)-butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL185601; BDBM50151810
Click to Show/Hide
|
||||
| Activity |
IC50 = 82120 nM
|
[31] | |||
| Compound Name |
(3R)-3-Amino-1-[3-(trifluoromethyl)-8-[[2-(trifluoromethyl)phenyl]methyl]-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL536090
Click to Show/Hide
|
||||
| Activity |
IC50 = 83000 nM
|
[23] | |||
| Compound Name |
cis-N-(4-((R)-1-Amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)-N-methylacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683098; CHEMBL1683099; BDBM50338464; BDBM50338465; trans-N-(4-((R)-1-amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)-N-methylacetamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 83000 nM
|
[18] | |||
| Compound Name |
Phe-Pro-CN
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL201268; BDBM11115; 4-substituted phenylalanine cyano-(S)-pyrrolidine deriv. 2; (2S)-1-[(2S)-2-amino-3-phenylpropanoyl]pyrrolidine-2-carbonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 = 84430 nM
|
[42] | |||
| Compound Name |
3-(4-((R)-1-Amino-2-(2,5-difluorophenyl)ethyl)piperidin-1-yl)cyclohexanecarboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683144; BDBM50338438
Click to Show/Hide
|
||||
| Activity |
IC50 = 85000 nM
|
[18] | |||
| Compound Name |
(R)-3-Amino-4-(2,5-difluorophenyl)-1-(3-isobutyl-2-(trifluoromethyl)-6,7-dihydro-3H-imidazo[4,5-c]pyridin-5(4H)-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL429829; BDBM50222478
Click to Show/Hide
|
||||
| Activity |
IC50 = 85000 nM
|
[28] | |||
| Compound Name |
(3R)-3-Amino-4-(2,5-difluorophenyl)-1-[2-methyl-3-(trifluoromethyl)-2H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-6-yl]butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
pyrazolopiperidine 62; CHEMBL371521; BDBM11961
Click to Show/Hide
|
||||
| Activity |
IC50 = 85000 nM
|
[19] | |||
| Compound Name |
Bis(4-acetamidophenyl) 1-((S)-2,6-diaminohexanoyl)pyrrolidin-2-ylphosphonate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL236781; BDBM50225423
Click to Show/Hide
|
||||
| Activity |
IC50 = 85000 nM
|
[35] | |||
| Compound Name |
(3R)-3-Amino-N-[1,1-dioxo-4-(1,3-thiazol-2-yl)thian-4-yl]-4-(2-fluorophenyl)butanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL469538; BDBM50275849
Click to Show/Hide
|
||||
| Activity |
IC50 = 85200 nM
|
[43] | |||
| Compound Name |
N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N-(4,4,4-trifluorobutyl)methanesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683097; BDBM50338463
Click to Show/Hide
|
||||
| Activity |
IC50 = 86000 nM
|
[18] | |||
| Compound Name |
(3R,4R)-1-Pteridin-7-yl-4-(2,4,5-trifluorophenyl)piperidin-3-amine;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL231195
Click to Show/Hide
|
||||
| Activity |
IC50 = 87000 nM
|
[16] | |||
| Compound Name |
(2R,3S,5R)-5-(2-Cyclopropylsulfonyl-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl)-2-(2,5-difluorophenyl)oxan-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3735329; SCHEMBL14845410
Click to Show/Hide
|
||||
| Activity |
IC50 = 87000 nM
|
[29] | |||
| Compound Name |
(2Z)-2-(1-Fluoro-2-{[(4-fluorophenyl)methyl]amino}ethylidene)cyclopentane-1-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Fluoro-Olefin Analogue 43; CHEMBL173824; BDBM12461; 11.7c/1; (1R,S)-(2Z)-2-{1-Fluoro-2-[(4-fluorobenzyl)amino]ethylidene}cyclopentanecarbonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 = 87300 nM
|
[21] | |||
| Compound Name |
(2R,3S,5R)-5-(1-Cyclopropylsulfonyl-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl)-2-(2,5-difluorophenyl)oxan-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3736190; SCHEMBL14845407
Click to Show/Hide
|
||||
| Activity |
IC50 = 88000 nM
|
[29] | |||
| Compound Name |
(2R,3R)-7-Methylsulfonyl-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-2-amine;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL559940
Click to Show/Hide
|
||||
| Activity |
IC50 = 88000 nM
|
[25] | |||
| Compound Name |
N-[5-[(3R,5S,6R)-5-Amino-6-(2,5-difluorophenyl)oxan-3-yl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]-1-pyridin-4-ylmethanesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3735433; BDBM50134195
Click to Show/Hide
|
||||
| Activity |
IC50 = 88000 nM
|
[29] | |||
| Compound Name |
2-Amino-1-piperidin-1-yl-butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL148285; ALBB-022685; BDBM50135080; 2-amino-1-piperidin-1-ylbutan-1-one; AKOS009839926; 1-oxo-1-piperidin-1-ylbutan-2-amine hydrochloride
Click to Show/Hide
|
||||
| Activity |
IC50 = 88700 nM
|
[20] | |||
| Compound Name |
(3R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(pyridin-2-ylmethyl)-1,4-diazepan-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Diazepanone Analog 25; CHEMBL216178; BDBM13527
Click to Show/Hide
|
||||
| Activity |
IC50 = 89000 nM
|
[32] | |||
| Compound Name |
(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxo-2-[4-(4-pyridin-1-ium-1-ylphenyl)phenyl]butanamide;2,2,2-trifluoroacetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL552503
Click to Show/Hide
|
||||
| Activity |
IC50 = 89000 nM
|
[26] | |||
| Compound Name |
(2S,3S)-3-Amino-N-ethyl-2-[4-(4-fluorophenyl)phenyl]-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL189067
Click to Show/Hide
|
||||
| Activity |
IC50 = 90000 nM
|
[26] | |||
| Compound Name |
(3R)-3-Amino-1-(2-cyclopropyl-1,4-dimethyl-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL400911; CHEMBL1204389; BDBM50222476; BDBM50371230
Click to Show/Hide
|
||||
| Activity |
IC50 = 90000 nM
|
[28] | |||
| Compound Name |
(2S,4R)-1-((2S,3R)-2-Amino-3-methylpentanoyl)-4-azidopyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL511659; BDBM50243688
Click to Show/Hide
|
||||
| Activity |
IC50 = 90000 nM
|
[22] | |||
| Compound Name |
Fluoro-Olefin Analogue 1
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL177180; BDBM12419; 9.7a; N-(2-cyclopentylidene-2-fluoroethyl)cyclohexanamine; N-(2-Cyclopentylidene-2-fluoroethyl)cyclohexan-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 90000 nM
|
[21] | |||
| Compound Name |
(3R,6R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-ethyl-6-methyl-1,4-diazepan-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
6-methyl diazepanone 14d; CHEMBL397242; BDBM15548
Click to Show/Hide
|
||||
| Activity |
IC50 = 90000 nM
|
[30] | |||
| Compound Name |
(3R,4R)-1-(3-Ethyl-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-amine;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL390080
Click to Show/Hide
|
||||
| Activity |
IC50 = 90000 nM
|
[16] | |||
| Compound Name |
Fluoro-Olefin Analogue 10
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL178975; BDBM12428; 9.8b; N-(2-Cyclohexylidene-2-fluoroethyl)-1-adamantan-amine; N-(2-cyclohexylidene-2-fluoroethyl)adamantan-1-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 91300 nM
|
[21] | |||
| Compound Name |
2-(Cyclohexylamino)-1-cyclopentylethanethione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL178843
Click to Show/Hide
|
||||
| Activity |
IC50 = 92000 nM
|
[21] | |||
| Compound Name |
(3R)-3-Amino-4-(2,5-difluorophenyl)-1-[2-methyl-3-(1,1,2,2,2-pentafluoroethyl)-2H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridin-5-yl]butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
pyrazolopiperidine 55; CHEMBL366166; BDBM11953
Click to Show/Hide
|
||||
| Activity |
IC50 = 92000 nM
|
[19] | |||
| Compound Name |
(R)-3-Amino-4-(2,5-difluorophenyl)-1-(1-methyl-2-(trifluoromethyl)-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL251205; BDBM50222475
Click to Show/Hide
|
||||
| Activity |
IC50 = 92000 nM
|
[28] | |||
| Compound Name |
(R)-3-Amino-1-thiazolidin-3-yl-4-o-tolyl-butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL185351; BDBM50151789
Click to Show/Hide
|
||||
| Activity |
IC50 = 92060 nM
|
[31] | |||
| Compound Name |
(3R,4R)-1-Pyrazino[2,3-b]pyrazin-3-yl-4-(2,4,5-trifluorophenyl)piperidin-3-amine;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL231196
Click to Show/Hide
|
||||
| Activity |
IC50 = 93000 nM
|
[16] | |||
| Compound Name |
(3R)-3-Amino-1-(4-ethyl-1-methyl-2-(trifluoromethyl)-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL250204; BDBM50222468
Click to Show/Hide
|
||||
| Activity |
IC50 = 93000 nM
|
[28] | |||
| Compound Name |
(2S,3S)-3-Amino-2-[4-(4-fluorophenyl)phenyl]-4-[(3R)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL372486
Click to Show/Hide
|
||||
| Activity |
IC50 = 94000 nM
|
[26] | |||
| Compound Name |
(2R,3S,5R)-5-[2-(Benzenesulfonyl)-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl]-2-(2,5-difluorophenyl)oxan-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3736511
Click to Show/Hide
|
||||
| Activity |
IC50 = 95000 nM
|
[29] | |||
| Compound Name |
(3R)-3-Amino-4-(2,5-difluorophenyl)-1-[2-(trifluoromethyl)-4H,5H,6H,7H-pyrido[3,4-d][1,3]thiazol-5-yl]butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
thiazolopiperidine 73; CHEMBL363375; BDBM11971
Click to Show/Hide
|
||||
| Activity |
IC50 = 95000 nM
|
[19] | |||
| Compound Name |
2,2,2-Trifluoroacetic acid;(3R,4R)-1-[3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL228311
Click to Show/Hide
|
||||
| Activity |
IC50 = 96000 nM
|
[16] | |||
| Compound Name |
2-(Tert-butylamino)-1-((2S,4S)-4-fluoro-2-(2-tert-pentyl-1,3,4-oxadiazole-5-carbonyl)pyrrolidin-1-yl)ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL399408; BDBM50214720
Click to Show/Hide
|
||||
| Activity |
IC50 = 97200 nM
|
[34] | |||
| Compound Name |
(2R,3R)-2-Amino-N,N-dimethyl-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazole-7-carboxamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL560729
Click to Show/Hide
|
||||
| Activity |
IC50 = 98000 nM
|
[25] | |||
| Compound Name |
(3R)-3-Amino-4-(3,4-difluorophenyl)-1-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL558196
Click to Show/Hide
|
||||
| Activity |
IC50 = 98000 nM
|
[38] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]isoquinoline-8-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2385279; BDBM50434190
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[44] | |||
| Compound Name |
(3R)-3-Amino-1-{2-cyclopropyl-4H,5H,6H,7H-pyrido[3,4-d][1,3]oxazol-5-yl}-4-(2,5-difluorophenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
oxazolopiperidine 77; CHEMBL197082; BDBM11975
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
2-[(5-Cyanopyridin-2-yl)amino]-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2385290; BDBM50434179
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[44] | |||
| Compound Name |
N-(1-Napthalenecarbonyl)-Gly-boroPro
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1243373; [(2R)-1-[2-(naphthalene-1-carbonylamino)acetyl]pyrrolidin-2-yl]boronic acid; GTPL9893; SCHEMBL15541697; BDBM50326373; compound 9 [PMID: 20718420]; (R)-1-(2-(1-naphthamido)acetyl)pyrrolidin-2-ylboronic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-2-(4-imidazo[1,2-a]pyridin-6-ylphenyl)-N,N-dimethyl-4-oxobutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL378673
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[36] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]quinoline-8-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2385280; SCHEMBL15129566; BDBM50434189
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[45] | |||
| Compound Name |
(3R)-4-[(3R)-3-Amino-4-(2,5-difluorophenyl)butanoyl]-1-cyclopropyl-3-methyl-1,4-diazepan-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
1-substituted diazepanone 9d; CHEMBL390885; BDBM15532
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
US9346814, Ref. Cmpd No 5
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3984057; BDBM233326
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[45] | |||
| Compound Name |
(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-2-[4-(2-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]-4-oxobutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL209710
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[36] | |||
| Compound Name |
(2R,3S,5R)-2-(2-Chloro-5-fluorophenyl)-5-(4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2425074; BDBM50440340
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[39] | |||
| Compound Name |
(2S,4S)-4-[[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]amino]-1-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]propanoyl]pyrrolidine-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4067185; BDBM50242266
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[46] | |||
| Compound Name |
(2S)-2-Amino-1-(1,3-dihydroisoindol-2-yl)-4-(4-piperidin-1-ylpiperidin-1-yl)butane-1,4-dione;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1814756
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
(S)-1-((2S,4R)-4-(2-(Isoindolin-2-yl)-2-oxoethyl)-5-oxopyrrolidine-2-carbonyl)pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1243403; SCHEMBL3395715; BDBM50326376
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
N-[2-[(2S,4R)-2-Cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233841; BDBM50009365
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]quinoline-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2385277; SCHEMBL15129564; BDBM50434159
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[45] | |||
| Compound Name |
(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-2-[4-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]-4-oxobutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL210621
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[36] | |||
| Compound Name |
N-[2-[(2S,4S)-4-Azido-2-cyanopyrrolidin-1-yl]-2-oxoethyl]naphthalene-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2022526; BDBM50382279
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[47] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-2-(4-fluorophenyl)-1H-imidazo[4,5-b]pyridine-7-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233573; BDBM50009354
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
N-[2-[(2S,4S)-2-Cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233840; BDBM50009364
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
6-Chloro-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2385301; SCHEMBL15138744; BDBM50434168
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[45] | |||
| Compound Name |
(2S)-1-(2-Benzamidoacetyl)-N-tert-butylpyrrolidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2022524; BDBM50382277
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[47] | |||
| Compound Name |
1-[(2S,4S)-4-(4-Cyclopropyltriazol-1-yl)-2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl]-4-phenylbutan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2179406; BDBM50399740
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
Benzamide, N-(2-oxo-2-(1-pyrrolidinyl)ethyl)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2022523; BRN 5026726; N-[2-oxo-2-(pyrrolidin-1-yl)ethyl]benzamide; N-(2-OXO-2-(PYRROLIDIN-1-YL)ETHYL)BENZAMIDE; N-(2-Oxo-2-(1-pyrrolidinyl)ethyl)benzamide; 1-(2-(N-Benzoyl)aminoethyl)-2-oxopyrrolidine; N-(2-oxo-2-pyrrolidin-1-ylethyl)benzamide; SCHEMBL1442608; CTK5H7550; DTXSID10241785; ZINC1999960; BDBM50382276; AKOS005262027; MCULE-8676559311; Z31480293
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[47] | |||
| Compound Name |
(2S,3S)-3-Amino-2-[4-(4-fluorophenyl)phenyl]-4-[(3S)-3-fluoropyrrolidin-1-yl]-N-(2-hydroxyethyl)-4-oxobutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL190593
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[26] | |||
| Compound Name |
5-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]-4-(hydroxymethyl)-1-methylpyridin-2-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL203169
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[49] | |||
| Compound Name |
trans-N-(4-((R)-1-Amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)-N-ethylacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683110; BDBM50338476
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[18] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-2-pyridin-4-ylacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233561; SCHEMBL15129716; BDBM50009342
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[45] | |||
| Compound Name |
2,2-Bis(4-chlorophenyl)-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2022508; BDBM50382253
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[47] | |||
| Compound Name |
(2S,4S)-1-{(2S,4S)-4-[2-(5-Chloro-1,3-dihydroisoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidine-2-carbonyl}-4-fluoropyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1243127; SCHEMBL16509426; BDBM50326391
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-N-(3-methylbutyl)quinoline-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233546; BDBM50009321
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
(2S,3R)-2-Amino-1-(4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)-3-methylpentan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3800132
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
(2R,3S,5R)-2-(2,5-Difluorophenyl)-5-[2-(trifluoromethyl)-4,6-dihydro-1H-pyrrolo[3,4-d]imidazol-5-yl]oxan-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2425069; BDBM50440344
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[39] | |||
| Compound Name |
(2s)-1-({(2s,4s)-4-[2-[4-(4-Chlorophenyl)-3,6-dihydropyridin-1(2h)-yl]-2-oxoethyl]-5-oxopyrrolidin-2-yl}carbonyl)pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1243061; SCHEMBL3399417; BDBM50326386
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(2S)-2-Amino-4-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-1-(2-methyl-4,6-dihydropyrrolo[3,4-d][1,3]thiazol-5-yl)butane-1,4-dione;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3797355
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
US9346814, Cmpd No 29 Example 34
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3929674; SCHEMBL15138774; BDBM233323
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[45] | |||
| Compound Name |
N-[2-[(2S)-2-Cyano-4-ethylpyrrolidin-1-yl]-2-oxoethyl]naphthalene-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2022532; BDBM50382285
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[47] | |||
| Compound Name |
(2s)-1-[1-(4-Phenylbutanoyl)-L-Prolyl]pyrrolidine-2-Carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
KYP-2047; CHEMBL189620; EX-A2764; KYP 2047; BDBM50155838; ZINC13584669; KYP-2047, >=95% (HPLC); 4-phenylbutanoyl-l-prolyl-2(s)-cyanopyrrolidine; Q27453163; (S)-1-((4-Phenylbutanoyl)-L-prolyl)pyrrolidine-2-carbonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
(2S)-1-(2-{[2-Oxo-2-(1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl]amino}acetyl)pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL371907; BDBM11696; (2S)-Cyanopyrrolidine analogue 17; 2-[2-[2-[2-Cyano-(S)-pyrrolidin-1-yl]-2-oxoethylamino]-1-oxo-ethyl]1,2,3,4-tetrahydroisoquinoline
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
8-Bromo-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2385275; SCHEMBL16267174; BDBM50434161; N-[2-[[(2S)-2alpha-Cyanopyrrolidine]-1-yl]-2-oxoethyl]-8-bromoquinoline-4-carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[45] | |||
| Compound Name |
1-Benzyl-7-but-2-ynyl-3-methyl-8-piperazin-1-ylpurine-2,6-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616904
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-3-phenylbenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2022513; BDBM50382267
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[47] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]isoquinoline-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2385276; BDBM50434160
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[44] | |||
| Compound Name |
US9051329, Example 5
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3687980; SCHEMBL14554341; BDBM162380
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[50] | |||
| Compound Name |
(2S,3S)-3-Amino-2-[4-(4-fluorophenyl)phenyl]-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutanoic acid;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL191327
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[26] | |||
| Compound Name |
3-[2-(2-Cyano-(S)-pyrrolidin-1-yl)-2-oxoethylamino]-N-(1-methyl-1-phenylethyl)propionamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL201158; 3-({2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl}amino)-N-(2-phenylpropan-2-yl)propanamide; 3-[[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]amino]-N-(2-phenylpropan-2-yl)propanamide; SCHEMBL3546283; BDBM11710; (2S)-Cyanopyrrolidine analogue 18n
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
(2S)-1-[2-(4-Naphthalen-1-yltriazol-1-yl)acetyl]pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233553; BDBM50009330
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-4-methyl-1,3-oxazole-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233569; SCHEMBL15129604; BDBM50009349
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[45] | |||
| Compound Name |
Tert-butyl N-[[1-[(3R,5S)-1-(4-phenylbutanoyl)-5-(pyrrolidine-1-carbonyl)pyrrolidin-3-yl]triazol-4-yl]methyl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2178957; BDBM50399719
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
Benzyl (2S,4S)-4-(4-phenyltriazol-1-yl)-2-(pyrrolidine-1-carbonyl)pyrrolidine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2178961; BDBM50399736
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
(2S)-1-(2-{[3-(6-Fluoro-1,2,3,4-tetrahydroisoquinolin-2-yl)-3-oxopropyl]amino}acetyl)pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL203084; BDBM11699; (2S)-Cyanopyrrolidine analogue 18c
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
trans-(R)-1-(4-((R)-1-Amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)piperidin-3-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683123; BDBM50338417
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[18] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-2-(4-methoxyphenyl)quinoline-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2385296; BDBM50434173
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[44] | |||
| Compound Name |
N-[5-[(3R,5S,6R)-5-Amino-6-(2,5-difluorophenyl)oxan-3-yl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]pyridine-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3735925; BDBM50134190
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[29] | |||
| Compound Name |
(2S,3R)-2-Amino-3-methyl-1-(2-methyl-4,6-dihydropyrrolo[3,4-d][1,3]thiazol-5-yl)pentan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3797536
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
1-[(4-Methoxyquinazolin-2-yl)methyl]-3-methyl-7-(3-methylbut-2-enyl)-8-(3-oxopiperazin-1-yl)purine-2,6-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616918
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(2R,3S,5R)-2-(2,5-Difluorophenyl)-5-(3-propan-2-ylsulfonyl-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3735694
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[29] | |||
| Compound Name |
(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-[4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]butanamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
MK-0626; CHEMBL537869
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[36] | |||
| Compound Name |
(2S)-1-({(2S,4S)-4-[2-[4-(4-Fluorophenyl)piperazin-1-yl]-2-oxoethyl]-5-oxopyrrolidin-2-yl}carbonyl)pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1243028; SCHEMBL3393509; BDBM50326384
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(2S)-2-Amino-4-[4-[(2-chloro-6-fluorophenyl)methyl]piperazin-1-yl]-1-(1,3-dihydroisoindol-2-yl)butane-1,4-dione;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1814744
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
4-Phenyl-1-[(2S,4S)-4-[4-(piperazin-1-ylmethyl)triazol-1-yl]-2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl]butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2178975; BDBM50399722
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
(2S,3S)-2-(4-Acetamidophenyl)-3-amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL245970
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
(2S)-2-Amino-4-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-1-(3-methylidenepyrrolidin-1-yl)butane-1,4-dione;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3800113
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-2-oxo-1H-quinoline-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2385295; BDBM50434174
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[44] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-6-(trifluoromethoxy)quinoline-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2385302; SCHEMBL15138749; BDBM50434167
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[45] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-2-phenylpyridine-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233558; SCHEMBL15129916; BDBM50009339
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[45] | |||
| Compound Name |
(S)-N-(2-(2-Cyanopyrrolidine-1-yl)-2-oxoethyl)-3-hydroxyquinoline-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2385298; SCHEMBL15129988; BDBM50434171; N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]-3-hydroxyquinoline-4-carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[45] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-2-naphthalen-1-yloxyacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2385285; BDBM50434184
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[44] | |||
| Compound Name |
(3R)-3-Amino-1-[(6R)-6-methyl-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL553787
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-2-(1H-imidazol-5-yl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233567; SCHEMBL15129888; BDBM50009333
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[45] | |||
| Compound Name |
(2R,3R)-7-Ethylsulfonyl-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-2-amine;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL560192
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
(2S,4S)-4-[[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]amino]-1-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]butanoyl]pyrrolidine-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4086264; BDBM50242264
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[46] | |||
| Compound Name |
2-Amino-1-(2,3-dihydro-1H-isoindol-2-yl)-4-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)butane-1,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
isoquinoline derivative 17; CHEMBL361107; SCHEMBL14392394; BDBM12194
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[51] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-3-methoxybenzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2022515; BDBM50382269
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[47] | |||
| Compound Name |
N-[2-[(2S)-2-Cyano-4-methylpyrrolidin-1-yl]-2-oxoethyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2021934; BDBM50382284
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[47] | |||
| Compound Name |
2-[3-[2-[2-Cyano-(S)-pyrrolidin-1-yl]-2-oxoethylamino]-3-methyl-1-oxobutyl]-1,3-dihydroisoindole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
(2S)-cyanopyrrolidine 4; CHEMBL201644; SCHEMBL1069325; BDBM11719; (2S)-Cyanopyrrolidine analogue 21d
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[52] | |||
| Compound Name |
(2S)-1-[2-[Methyl(quinolin-4-ylmethyl)amino]acetyl]pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233548; BDBM50009324
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
(2S,3S)-3-Amino-4-(3-fluoroazetidin-1-yl)-N,N-dimethyl-4-oxo-2-[4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]butanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL210974
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[36] | |||
| Compound Name |
(2S)-1-[(2S)-4-[2-(1,3-Dihydroisoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidine-2-carbonyl]pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1243248
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Benzyl (2S,4S)-4-[4-[[(2-methylpropan-2-yl)oxycarbonylamino]methyl]triazol-1-yl]-2-(pyrrolidine-1-carbonyl)pyrrolidine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2179408; BDBM50399738
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
N-[(2R)-1-[(2S)-2-Cyanopyrrolidin-1-yl]-3-hydroxy-1-oxopropan-2-yl]quinoline-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233538; SCHEMBL15129756; BDBM50009313
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[45] | |||
| Compound Name |
US9346814, Cmpd No 27 Example 32
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3900683; BDBM233322
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[45] | |||
| Compound Name |
4-[4-[Bis(4-fluorophenyl)methyl]piperazin-1-yl]-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]-4-oxobutanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2022520; BDBM50382273
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[47] | |||
| Compound Name |
1-[4-[Bis(4-fluorophenyl)methyl]piperazin-1-yl]-4-(1,3-dihydroisoindol-2-yl)butane-1,4-dione;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1814738
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-2-thiophen-2-ylacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2022506; BDBM50382261
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[47] | |||
| Compound Name |
(2S)-1-[(2S,4S)-4-[2-(5,7-Dihydro-4H-thieno[2,3-c]pyridin-6-yl)-2-oxoethyl]-5-oxopyrrolidine-2-carbonyl]pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242993; BDBM50326381
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(2S,3S)-2-Amino-3-methyl-1-(4-methylisoindolin-2-yl)pentan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL469892; BDBM50242853
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-4-[4-[(4-fluorophenyl)methyl]piperazin-1-yl]-4-oxobutanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2022519; BDBM50382272
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[47] | |||
| Compound Name |
(2S)-1-[(2S,4S)-5-Oxo-4-[2-oxo-2-[2-(trifluoromethyl)-6,8-dihydro-5H-imidazo[1,2-a]pyrazin-7-yl]ethyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242994; SCHEMBL16509428; BDBM50326382
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-2-naphthalen-2-yloxyacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2385284; BDBM50434185
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[44] | |||
| Compound Name |
(2S,3S)-3-Amino-2-[4-(4-fluorophenyl)phenyl]-4-[(3S)-3-fluoropyrrolidin-1-yl]-N-methyl-4-oxobutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL190752
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[26] | |||
| Compound Name |
(2s)-1-({(2s,4s)-4-[2-(1,3-Dihydro-2h-isoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidin-2-yl}carbonyl)-4,4-difluoropyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1243153; SCHEMBL3395679; BDBM50326392
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
(2R,3R)-8-Methylsulfonyl-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-2-amine;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL549645
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]naphthalene-1-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2385289; BDBM50434180
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[44] | |||
| Compound Name |
1-(4-Methylquinazoline-2-ylmethyl)-3-methyl-7-(2-butynyl)-8-[(5S)-3-oxo-5-(hydroxymethyl)piperazino]xanthine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616896
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
7-But-2-ynyl-3-methyl-1-[(5-methyl-2-phenyltriazol-4-yl)methyl]-8-piperazin-1-ylpurine-2,6-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616907
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(S)-N-(2-(2-Cyanopyrrolidin-1-yl)-2-oxoethyl)quinoline-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2385281; SCHEMBL15138980; BDBM50434188; (S)-N-(2-(2-cyanopyrrolidine-1-yl)-2-oxoethyl)quinoline-4-carboxamide; N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[45] | |||
| Compound Name |
US9051329, Example 2
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3687978; SCHEMBL14554395; BDBM162377
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[50] | |||
| Compound Name |
7-But-2-ynyl-3-methyl-8-piperazin-1-yl-1-[[4-(1,2,4-triazol-1-yl)phenyl]methyl]purine-2,6-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616909
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
N-[2-[(2S)-2-(2-Chloroacetyl)pyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233848; BDBM50009372
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
(3R)-3-Amino-1-[8-ethyl-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL556606
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
2-(3,4-Difluorophenyl)-1,2,3,4-tetrahydroisoquinoline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
isoquinoline derivative 10; CHEMBL180664; BDBM12187; AKOS027557967
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[51] | |||
| Compound Name |
(2S)-1-(2-{[3-(2,3-Dihydro-1H-isoindol-2-yl)-3-oxopropyl]amino}acetyl)pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL381530; BDBM11700; (2S)-Cyanopyrrolidine analogue 18d; 2-[3-[2-[2-Cyano-(S)-pyrrolidin-1-yl]-2-oxoethylamino]-1-oxo-propyl]1,3-dihydroisoindole
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
7-But-2-ynyl-8-ethoxy-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]purine-2,6-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616893
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-5-methylquinoline-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233835; SCHEMBL15129783; BDBM50009360
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[45] | |||
| Compound Name |
4-Phenyl-1-[(2S,4S)-4-(4-phenyltriazol-1-yl)-2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl]butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2178962; BDBM50399735
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
1-[(2S,4S)-4-[4-[(Dimethylamino)methyl]triazol-1-yl]-2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl]-4-phenylbutan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2178972; BDBM50399725
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-N-(2-methoxyethyl)quinoline-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233545; BDBM50009320
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
N-[2-[(2S,4S)-4-Azido-2-cyanopyrrolidin-1-yl]-2-oxoethyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2022525; BDBM50382278
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[47] | |||
| Compound Name |
N-(N-(Phenyl)butyryl-L-prolyl)pyrrolidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Suam-1221; Suam 1221; CHEMBL289651; SCHEMBL6285952; 1-Butanone,4-phenyl-1-[(2S)-2-(1-pyrrolidinylcarbonyl)-1-pyrrolidinyl]-; CTK4A7890; DTXSID40150119; BDBM50051539; 4-phenyl-1-[(2S)-2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl]butan-1-one; N-[N-(gamma-phenyl)butyryl-L-prolyl]pyrrolidine; (S)-4-phenyl-1-(2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl)butan-1-one; 4-Phenyl-1-[(S)-2-(pyrrolidine-1-carbonyl)-pyrrolidin-1-yl]-butan-1-one; 4-Phenyl-1-[2-(pyrrolidine-1-carbonyl)-pyrrolidin-1-yl]-butan-1-one; Pyrrolidine, 1-(1-oxo-4-phenylbutyl)-2-(1-pyrolidinylcarbonyl)-, (S)-
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
(R)-1-(2-(Quinoline-4-carboxamido)acetyl)pyrrolidin-2-ylboronic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233847; SCHEMBL15129800; BDBM50009370; [(2R)-1-[2-(quinoline-4-carbonylamino)acetyl]pyrrolidin-2-yl]boronic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
(S)-N-(2-(2-Cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)quinoline-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SP-13786; UAMC-1110; CHEMBL3233842; SCHEMBL15138917; EX-A2803; BDBM50009366; MFCD29477499; ZB1498; ZINC169312174; CS-6200; SB19734; KS-000006B7; AS-35289; HY-100684; S0842
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[45] | |||
| Compound Name |
CID 89705098
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233575; SCHEMBL15129785; BDBM50009357; N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]-[1,2,4]triazolo[1,5-a]pyrimidine-7-carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[45] | |||
| Compound Name |
(2s)-1-({(2s,4s)-4-[2-(5-Trifluoromethyl-1,3-dihydro-2h-isoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidin-2-yl}carbonyl)pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242966; SCHEMBL3395102; BDBM50326379
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-[4-[Bis(4-fluorophenyl)methyl]piperazin-1-yl]-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2022516; BDBM50382258
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[47] | |||
| Compound Name |
Fluoro-Olefin Analogue 11
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL175442; BDBM12429; 9.8c; N-(2-cyclohexylidene-2-fluoroethyl)aniline
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[21] | |||
| Compound Name |
1-[(2S,4S)-4-[4-(2,4-Difluorophenyl)triazol-1-yl]-2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl]-4-phenylbutan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2178964; BDBM50399733
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
1-[(2S,4S)-4-(4-Cyclohexyltriazol-1-yl)-2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl]-4-phenylbutan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2179407; BDBM50399739
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
N-[5-[(3R,5S,6R)-5-Amino-6-(2,5-difluorophenyl)oxan-3-yl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]cyclopropanesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3734999; BDBM50134194
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[29] | |||
| Compound Name |
(3R)-3-Amino-4-(2,5-difluorophenyl)-1-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL537400
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[38] | |||
| Compound Name |
(2R,3S,5R)-5-(1-Cyclopentylsulfonyl-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl)-2-(2,5-difluorophenyl)oxan-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3645492; SCHEMBL14845408; BDBM107101; US8592371, 3
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[29] | |||
| Compound Name |
7-But-2-ynyl-3-methyl-8-(3-oxopiperazin-1-yl)purine-2,6-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616915
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(2S)-2-Amino-3-[4-(4-fluorophenyl)phenyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]propan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL189645
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[26] | |||
| Compound Name |
Tert-butyl N-[[1-[(3S,5S)-5-[(2S)-2-cyanopyrrolidine-1-carbonyl]-1-(4-phenylbutanoyl)pyrrolidin-3-yl]triazol-4-yl]methyl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2178959; BDBM50399717
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
(2S)-1-[2-[2-Methoxyethyl(quinolin-4-ylmethyl)amino]acetyl]pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233547; BDBM50009322
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
(3S)-2-[(2S)-2-Amino-3-(1H-indol-3-yl)propanoyl]-3,4-dihydro-1H-isoquinoline-3-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL180000
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[51] | |||
| Compound Name |
(S)-2-Amino-2-cyclohexyl-1-(pyrrolidin-1-YL)ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL278393; isoquinoline derivative 14; SCHEMBL14392401; BDBM12191; MB11305; (S)-2-Amino-2-cyclohexyl-1-pyrrolidin-1-yl-ethanone; (2S)-2-amino-2-cyclohexyl-1-(pyrrolidin-1-yl)ethan-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[51] | |||
| Compound Name |
trans-4-((4-((R)-1-Amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)(methyl)amino)-4-oxobutanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683103; BDBM50338469
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[18] | |||
| Compound Name |
(2S,4S)-4-[[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]amino]-1-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]hexanoyl]pyrrolidine-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4090635; BDBM50242274
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[46] | |||
| Compound Name |
3-[2-(2-Cyano-(S)-pyrrolidin-1-yl)-2-oxoethylamino]-N-(1-phenylpropyl)propionamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
3-({2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl}amino)-N-(1-phenylpropyl)propanamide; 3-[[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]amino]-N-(1-phenylpropyl)propanamide; CHEMBL201695; SCHEMBL3554544; BDBM11707; (2S)-Cyanopyrrolidine analogue 18k
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
(1R,2S,5S)-3-[(2S,3R)-2-Amino-3-methylpentanoyl]-3-azabicyclo[3.1.0]hexane-2-carbonitrile;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3799074
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
2-[(3S,5S)-5-[(2S)-2-Cyanopyrrolidine-1-carbonyl]-2-oxopyrrolidin-3-yl]-N-phenylacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1243093; SCHEMBL3395680; BDBM50326389; 2-[(3s,5s)-5-{[(2s)-2-cyanopyrrolidin-1-yl]carbonyl}-2-oxopyrrolidin-3-yl]-n-phenylacetamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Benzyl (2S,4S)-4-(4-pyridin-2-yltriazol-1-yl)-2-(pyrrolidine-1-carbonyl)pyrrolidine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2178968; BDBM50399729
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
(2S,3R)-2-Amino-3-methyl-1-(3-methylidenepyrrolidin-1-yl)pentan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3798975
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
2-[(3R,5S,6R)-5-Amino-6-(2,5-difluorophenyl)oxan-3-yl]-3H-isoindol-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2425066; BDBM50440347
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[39] | |||
| Compound Name |
US9346814, Ref. Cmpd No 4
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3896942; BDBM233325
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[45] | |||
| Compound Name |
(2S,3S)-2-Amino-N-cyclopentyl-3-methylpentanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
N-Cyclopentyl L-isoleucinamide; CHEMBL457550; N-Cyclopentylisoleucinamide; BDBM50243557; ZINC11959231; K-5714
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
3,7-Dimethyl-8-(3-oxopiperazin-1-yl)purine-2,6-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616914
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
8-Chloro-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2385274; SCHEMBL15138756; BDBM50434162
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[45] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-7-phenylquinoline-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233836; SCHEMBL15130008; BDBM50009332
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[45] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-4-methyl-1,3-thiazole-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233568; SCHEMBL15129841; BDBM50009348
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[45] | |||
| Compound Name |
Tert-butyl N-[[1-[(3S,5S)-1-(4-phenylbutanoyl)-5-(pyrrolidine-1-carbonyl)pyrrolidin-3-yl]triazol-4-yl]methyl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2178960; BDBM50399737
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
(2S)-1-[2-[[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-methylamino]acetyl]pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233549; BDBM50009325
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
N-{2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl}benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2024672; SCHEMBL10022743; CTK3H4478; DTXSID20580319; BDBM50382254; (S)-N-(2-(2-Cyanopyrrolidin-1-yl)-2-oxoethyl)benzamide; Benzamide, N-[2-[(2S)-2-cyano-1-pyrrolidinyl]-2-oxoethyl]-
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[47] | |||
| Compound Name |
2,6-Dichloro-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2022511; BDBM50382265
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[47] | |||
| Compound Name |
N-[2-[(2S,4S)-2-Cyano-4-(trifluoromethyl)pyrrolidin-1-yl]-2-oxoethyl]naphthalene-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2022533; BDBM50382255
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[47] | |||
| Compound Name |
(2S,4S)-1-[(2S)-2-Amino-3-(2-cyanophenyl)propanoyl]-4-fluoropyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3093911; BDBM50443748
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[42] | |||
| Compound Name |
(2S,3S)-2-Amino-3-methyl-1-(5H-pyrrolo[3,4-b]pyridin-6(7H)-yl)pentan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL453199; BDBM50243083
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
1-(Quinoline-2-ylmethyl)-3-methyl-7-(2-butynyl)-8-piperazinoxanthine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616902; BDBM50277300
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(3R)-4-[(3R)-3-Amino-4-(2,5-difluorophenyl)butanoyl]-1-ethyl-3-methyl-1,4-diazepan-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
1-substituted diazepanone 9a; CHEMBL231009; BDBM15529
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
(3s,5s)-3-[2-(1,3-Dihydro-2h-isoindol-2-yl)-2-oxoethyl]-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1243154; SCHEMBL3395728; BDBM50326393; (3S,5S)-3-[2-(1,3-dihydroisoindol-2-yl)-2-oxoethyl]-5-(1,3-thiazolidine-3-carbonyl)pyrrolidin-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
7-But-2-ynyl-1-[[2-(hydroxymethyl)-1,3-thiazol-4-yl]methyl]-3-methyl-8-piperazin-1-ylpurine-2,6-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616888
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(2S)-1-[(2R)-1-(4-Phenylbutanoyl)pyrrolidine-2-carbonyl]pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2024671; BDBM50382287
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[47] | |||
| Compound Name |
(2R,3R,5R)-2-(2,5-Difluorophenyl)-5-(4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2425082; BDBM50440335
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[39] | |||
| Compound Name |
(1S,2R,5S)-5-(3-(Trifluoromethyl)-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)-2-(2,4,5-trifluorophenyl)cyclohexanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL234635; BDBM50210527
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[53] | |||
| Compound Name |
1-(4-Methylquinazoline-2-ylmethyl)-3-methyl-7-(2-butynyl)-8-[2-(acetylamino)ethylamino]xanthine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616898
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
4-Phenyl-1-[(2S,4R)-4-(4-phenyltriazol-1-yl)-2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl]butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2178956; BDBM50399720
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
(3R)-3-Amino-1-[8-[[3,5-bis(trifluoromethyl)phenyl]methyl]-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL536312
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
(2S,3S)-3-Amino-2-(4-(1,8a-dihydro-[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl)-4-((S)-3-fluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxobutanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL459357; BDBM50276598
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[54] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-4-[(2,2,2-trifluoroacetyl)amino]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233571; BDBM50009351
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-3-methylimidazole-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233564; SCHEMBL15129945; BDBM50009345
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[45] | |||
| Compound Name |
(2s)-1-({(2s,4s)-5-Oxo-4-[2-oxo-2-(pyrrolidin-1-yl)ethyl]pyrrolidin-2-yl}carbonyl)pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1243091; SCHEMBL3393495; BDBM50326387
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-[4-[(7-But-2-ynyl-3-methyl-2,6-dioxo-8-piperazin-1-ylpurin-1-yl)methyl]phenyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616906
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(R)-3-Amino-1-(2-cyclopropyl-5,6-dihydro-[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL248936; SCHEMBL5230936; BDBM50221441
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[24] | |||
| Compound Name |
7-But-2-ynyl-3-methyl-1-(naphthalen-2-ylmethyl)-8-piperazin-1-ylpurine-2,6-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616903
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(R)-3-Amino-1-(5,6-dihydro-[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL248743; BDBM50221450
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[24] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-1H-indole-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2385282; BDBM50434187
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[44] | |||
| Compound Name |
(2R,3S,5R)-2-(2,5-Difluorophenyl)-5-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]oxan-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2425063; BDBM50440349
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[39] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-1H-indole-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2385283; BDBM50434186
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[44] | |||
| Compound Name |
(3R)-3-Amino-4-(2,5-difluorophenyl)-1-[3-(1,1,2,2,2-pentafluoroethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL559011
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[38] | |||
| Compound Name |
1-(4-Methoxyquinazoline-2-ylmethyl)-3-methyl-7-(2-butynyl)-8-piperazinoxanthine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616901; BDBM50277301
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-2H-triazole-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233565; SCHEMBL15139038; BDBM50009346; (S)-N-(2-(2-cyanopyrrolidine-1-yl)-2-oxoethyl)-1H-1,2,3-triazole-5-carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[45] | |||
| Compound Name |
(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxo-2-[4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]butanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL377221
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
(2R,3S,5R)-2-(2-Chlorophenyl)-5-(4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2425071; BDBM50440343
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[39] | |||
| Compound Name |
N-[2-[(2S)-2-Cyano-4-methylidenepyrrolidin-1-yl]-2-oxoethyl]naphthalene-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2022531; BDBM50382257
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[47] | |||
| Compound Name |
(2S,3S)-3-Amino-N,N-dimethyl-4-oxo-4-pyrrolidin-1-yl-2-[4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]butanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL378048
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[36] | |||
| Compound Name |
5-Bromo-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2385300; SCHEMBL15130006; BDBM50434169
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[45] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-2-(3,4-dimethoxyphenyl)pyridine-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233559; SCHEMBL15129796; BDBM50009340
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[45] | |||
| Compound Name |
(2S)-1-(2-{[3-(6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)-3-oxopropyl]amino}acetyl)pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL424854; BDBM11698; (2S)-Cyanopyrrolidine analogue 18b
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
1-(4-Methylquinazoline-2-ylmethyl)-3-methyl-7-(2-butynyl)-8-[2-(4-pyridylcarbonylamino)ethylamino]xanthine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616899
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
2-[7-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-8-yl]-N,N-dimethylacetamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL556979
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
(R)-3-Amino-4-(2-fluorophenyl)-1-(piperazin-1-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL184624; BDBM50151819; (R)-3-Amino-4-(2-fluoro-phenyl)-1-piperazin-1-yl-butan-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
Benzyl (2S,4S)-2-(pyrrolidine-1-carbonyl)-4-(4-trimethylsilyltriazol-1-yl)pyrrolidine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2179405; BDBM50399741
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
Allo-Ile-Isoindoline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL397070; SCHEMBL14392574; BDBM50225437; ZINC28826977; NCGC00387470-01; (2S,3R)-2-amino-1-(isoindolin-2-yl)-3-methylpentan-1-one; (2S,3R)-2-amino-1-(1,3-dihydroisoindol-2-yl)-3-methylpentan-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(2S)-1-[(2S,4S)-4-Azido-1-(4-phenylbutanoyl)pyrrolidine-2-carbonyl]pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2178958; BDBM50399718
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
N-[5-[(3R,5S,6R)-5-Amino-6-(2,5-difluorophenyl)oxan-3-yl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]-2,2,2-trifluoroethanesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3735461; BDBM50134193
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[29] | |||
| Compound Name |
Tert-butyl 4-[[1-[(3S,5S)-1-(4-phenylbutanoyl)-5-(pyrrolidine-1-carbonyl)pyrrolidin-3-yl]triazol-4-yl]methyl]piperazine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2178974; BDBM50399723
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
(2S)-N-Tert-butyl-1-[(2S,4S)-4-[2-(1,3-dihydroisoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidine-2-carbonyl]pyrrolidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1243215; BDBM50326396
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(3R)-3-Amino-1-[(8R)-8-methyl-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL558779
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
US9051329, Example 1
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3687977; SCHEMBL14554328; US9051329, Example 4; BDBM162376
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[50] | |||
| Compound Name |
(2S)-1-({(2S,4S)-5-Oxo-4-[2-oxo-2-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]ethyl]pyrrolidin-2-yl}carbonyl)pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1243027; SCHEMBL16509425; BDBM50326383
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
US9346814, Ref. Cmpd No 3 (Example 5)
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3937692; SCHEMBL16267642; BDBM233321; N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]quinoline-3-carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[45] | |||
| Compound Name |
8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-ynyl-3-methyl-1-propan-2-ylpurine-2,6-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616913
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(2R)-2-[4-[[[(2S)-1-(2-Amino-2-cyclohexylacetyl)pyrrolidine-2-carbonyl]amino]methyl]phenoxy]-3-methylbutanoic acid;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL183418
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
(3R)-3-Amino-1-[8-(pyridin-2-ylmethyl)-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL557176
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
(2S,3S)-2-Amino-3-methyl-1-(5-methylisoindolin-2-yl)pentan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL469669; BDBM50242931
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
(2S,3S)-2-Amino-1-(5-tert-butylisoindolin-2-yl)-3-methylpentan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL469678; BDBM50243077
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-3-phenylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2022505; BDBM50382260
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[47] | |||
| Compound Name |
(2R,3S,5R)-2-(2,5-Difluorophenyl)-5-[2-(trifluoromethylsulfonyl)-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl]oxan-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3736188
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[29] | |||
| Compound Name |
(S)-N-(2-(2-Cyanopyrrolidin-1-yl)-2-oxoethyl)-1-naphthamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1243374; SCHEMBL715747; BDBM50326374; N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]naphthalene-1-carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[47] | |||
| Compound Name |
(2S)-1-(2-{[3-Oxo-3-(1,2,3,4-tetrahydroisoquinolin-2-yl)propyl]amino}acetyl)pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL200103; SCHEMBL3555830; BDBM11697; (2S)-Cyanopyrrolidine analogue 18a; (2S)-1-[2-[[3-(3,4-dihydro-1H-isoquinolin-2-yl)-3-oxopropyl]amino]acetyl]pyrrolidine-2-carbonitrile; 2-[3-[2-[2-Cyano-(S)-pyrrolidin-1-yl]-2-oxoethylamino]-1-oxo-propyl]1,2,3,4-tetrahydroisoquinoline
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
1-(4-Methylquinazoline-2-ylmethyl)-3-methyl-7-(2-butynyl)-8-[(6S)-1,4-diazabicyclo[4.3.0]nonane-4-yl]xanthine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616891
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
N-[(2S)-1-[(2S)-2-Cyanopyrrolidin-1-yl]-1-oxopropan-2-yl]quinoline-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233540; BDBM50009315
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
2-(4-Cyanophenyl)-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]pyridine-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233560; SCHEMBL15129643; BDBM50009341
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[45] | |||
| Compound Name |
Benzyl (S)-(-)-2-(1-pyrrolidinylcarbonyl)-1-pyrrolidinecarboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
(S)-benzyl 2-(pyrrolidine-1-carbonyl)pyrrolidine-1-carboxylate; benzyl (2S)-2-(pyrrolidine-1-carbonyl)pyrrolidine-1-carboxylate; CHEMBL1088406; SCHEMBL6384850; CTK1G8492; ZINC57064; DTXSID60350871; 7039AB; BDBM50316820; AKOS015891421; AS-71480; ST51038407; benzyl (S)-2-(1-pyrrolidinylcarbonyl)-1-pyrrolidinecarboxylate; phenylmethyl (2S)-2-(pyrrolidinylcarbonyl)pyrrolidinecarboxylate; Benzyl(S)-(-)-2-(1-pyrrolidinylcarbonyl)-1-pyrrolidinecarboxylate; Benzyl (S)-(-)-2-(1-pyrrolidinyl carbonyl)-1-pyrrolidinecarboxylate; Benzyl (S)-(-)-2-(1-pyrrolidinylcarbonyl)-1-pyrrolidinecarboxylate, 97%; (2S)-2-[(Pyrrolidin-1-yl)carbonyl]pyrrolidine-1-carboxylic acid benzyl ester
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
7-Anilino-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233837; SCHEMBL15129788; BDBM50009361
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[45] | |||
| Compound Name |
3-[2-(2-Cyanopyrrolidin-1-yl)-2-oxo-ethylamino]-3-methyl-N-(1-methyl-1-phenylethyl)butyramide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL202711; BDBM11720; (2S)-Cyanopyrrolidine analogue 21e; 3-({2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl}amino)-3-methyl-N-(2-phenylpropan-2-yl)butanamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]pyridazine-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233563; BDBM50009344
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
(2S)-1-(2-Naphthalen-2-yloxyacetyl)pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2385288; BDBM50434181
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[44] | |||
| Compound Name |
2-[4-[[[(4R)-3-[3-Amino-4-(2-fluorophenyl)butanoyl]-1,3-thiazolidine-4-carbonyl]amino]methyl]phenyl]acetic acid;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL183060
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
(2S,3R,5R)-2-(2,5-Difluorophenyl)-5-(4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2425078; BDBM50440337
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[39] | |||
| Compound Name |
cis-(R)-2-(2,5-Difluorophenyl)-1-(4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)cyclohexyl)ethanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1681802; CHEMBL1683115; BDBM50338408; BDBM50338409
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[18] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-2-naphthalen-1-ylacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2385286; BDBM50434183
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[44] | |||
| Compound Name |
N'-[Bis(4-fluorophenyl)methyl]-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]butanediamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2022518; BDBM50382271
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[47] | |||
| Compound Name |
(2S,3S,5R)-2-(2,5-Difluorophenyl)-5-(4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2425079; BDBM50440333
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[39] | |||
| Compound Name |
7-[(3R,4R)-3-Amino-4-(2,4,5-trifluorophenyl)piperidin-1-yl]-2-methylpyrimido[1,2-b]pyridazin-4-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL231397
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
(S)-N-(2-(2-Cyanopyrrolidine-1-yl)-2-oxoethyl)piperidine-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233562; SCHEMBL15129577; BDBM50009343; N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]piperidine-4-carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[45] | |||
| Compound Name |
7-But-2-ynyl-3-methyl-8-(3-oxopiperazin-1-yl)-1-(pyridin-3-ylmethyl)purine-2,6-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616911
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
7-Benzyl-1-[(4-methoxyquinazolin-2-yl)methyl]-3-methyl-8-(3-oxopiperazin-1-yl)purine-2,6-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616920
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(2S,3R)-2-Amino-3-[4-(4-fluorophenyl)phenyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-4-(tetrazol-1-yl)butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL359581
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[26] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-2-[4-(3,4-difluorophenyl)triazol-1-yl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2022521; BDBM50382274
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[47] | |||
| Compound Name |
(3R)-3-Amino-4-(2,5-difluorophenyl)-1-(1,4-dimethyl-2-(trifluoromethyl)-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL250006; BDBM50222481
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[28] | |||
| Compound Name |
(2E)-2-[2-(Adamantan-1-ylamino)-1-fluoroethylidene]cyclopentane-1-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Fluoro-Olefin Analogue 45; CHEMBL180514; BDBM12463; 11.7b/2; (1R,S)-(2E)-2-[2-(1-Adamantylamino)-1-fluoroethylidene]cyclopentanecarbonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
(2R,3S,5R)-2-(2,5-Difluorophenyl)-5-(2-propan-2-ylsulfonyl-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3735865
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[29] | |||
| Compound Name |
US9051329, Example 7
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3687982; SCHEMBL14554312; BDBM162382
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[50] | |||
| Compound Name |
1-(4-Methylquinazoline-2-ylmethyl)-3-methyl-7-(2-butynyl)-8-(3-oxopiperazino)xanthine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616895
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(2Z)-2-[2-(Adamantan-1-ylamino)-1-fluoroethylidene]cyclopentane-1-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Fluoro-Olefin Analogue 42; CHEMBL177980; BDBM12460; 11.7b/1; (1R,S)-(2Z)-2-[2-(1-Adamantylamino)-1-fluoroethylidene]cyclopentanecarbonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-3-hydroxy-2-methylquinoline-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2385294; SCHEMBL15138746; BDBM50434175
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[45] | |||
| Compound Name |
(R)-3-Amino-4-(2-fluoro-phenyl)-1-((R)-2-methyl-piperazin-1-yl)-butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL264551; BDBM50151824
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
(11R,12R)-11-(2,4,5-Trifluorophenyl)-1,5,8-triazatricyclo[7.4.0.02,7]trideca-2(7),3,5,8-tetraen-12-amine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL552068
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]pyridine-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233554; SCHEMBL15139029; BDBM50009334
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[45] | |||
| Compound Name |
(2S)-1-[(2S,4S)-4-[2-(1,3-Dihydroisoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidine-2-carbonyl]pyrrolidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1243216; BDBM50326397
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Sitagliptin Hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
UNII-IEL0A0OS7E; IEL0A0OS7E; Sitagliptin HCl; CHEMBL539077; SCHEMBL1533793; Q27280690
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
1-(4-Methylquinazoline-2-ylmethyl)-3-methyl-7-(2-butynyl)-8-piperazinoxanthine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616890; SCHEMBL1772451; BDBM50277311; 1-[(4-Methylquinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-(piperazin-1-yl)-xanthine; 7-but-2-ynyl-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]-8-piperazin-1-ylpurine-2,6-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(3R)-3-Amino-1-[(4R)-4-methyl-6-(trifluoromethyl)-3,4-dihydro-1H-pyrrolo[1,2-a]pyrazin-2-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2021529
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
(2S)-1-[3-Amino-4-(2-fluorophenyl)butanoyl]-N-[4-(2H-tetrazol-5-yl)butyl]pyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL184346
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
1-[(2S,4S)-4-[4-(Morpholin-4-ylmethyl)triazol-1-yl]-2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl]-4-phenylbutan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2178973; BDBM50399724
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]naphthalene-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2022514; BDBM50382268
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[47] | |||
| Compound Name |
(2S)-1-({(2S,4S)-4-[2-(1,3-Dihydro-2H-isoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidin-2-yl}carbonyl)pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1243402; SCHEMBL3393551; BDBM50326375
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(2R,3S,5R)-2-(2,5-Difluorophenyl)-5-[2-[3-(trifluoromethyl)phenyl]sulfonyl-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl]oxan-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3736067; BDBM50135035
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[29] | |||
| Compound Name |
(2S)-2-Amino-4-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-1-(4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)butane-1,4-dione;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3800436
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-7-methylquinoline-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233834; SCHEMBL15129765; BDBM50009359
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
(3R)-3-Amino-1-[8-[(4-fluorophenyl)-hydroxymethyl]-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL536536
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
N'-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-N-[(4-fluorophenyl)methyl]butanediamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2022517; BDBM50382270
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[47] | |||
| Compound Name |
(1S,2R,5R)-5-(3-(Trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-2-(2,4,5-trifluorophenyl)cyclohexanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL232191; SCHEMBL13938022; BDBM50210526
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[53] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-1,2,3,4-tetrahydroacridine-9-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2385297; BDBM50434172
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[44] | |||
| Compound Name |
(3S,5S)-3-[2-(1,3-Dihydroisoindol-2-yl)-2-oxoethyl]-5-(pyrrolidine-1-carbonyl)pyrrolidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1243183; SCHEMBL16502392; BDBM50326394
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(2S)-2-[4-[[[(2S)-1-[(3R)-3-Amino-4-(2,5-difluorophenyl)butanoyl]pyrrolidine-2-carbonyl]amino]methyl]phenoxy]-3-methylbutanoic acid;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL445949
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[54] | |||
| Compound Name |
1-[(4-Methoxyquinazolin-2-yl)methyl]-3,7-dimethyl-8-(3-oxopiperazin-1-yl)purine-2,6-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616916
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(R)-3-Amino-1-[(R)-2-(4-fluoro-benzyl)-piperazin-1-yl]-4-(2-fluoro-phenyl)-butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL184902; BDBM50151834
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
7-Bromo-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2385273; SCHEMBL15129949; BDBM50434163
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[45] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-2-methylquinoline-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2385293; SCHEMBL15138987; BDBM50434176
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[45] | |||
| Compound Name |
(2S,4S)-4-[[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]amino]-1-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]pentanoyl]pyrrolidine-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4078112; BDBM50242265
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[46] | |||
| Compound Name |
Unii-Z82X63Q1Z5
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Z82X63Q1Z5; CHEMBL3616894; Linagliptin metabolite m515(1)
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
((2S,4S)-4-(Dinaphthalen-2-ylamino)pyrrolidin-2-yl)(isoindolin-2-yl)methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL452268; BDBM50243315
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
4-Amino-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233570; BDBM50009350
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
N-[2-[(2S)-2-Cyano-4,4-difluoropyrrolidin-1-yl]-2-oxoethyl]-6-methoxyquinoline-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233843; SCHEMBL15130010; BDBM50009331
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[45] | |||
| Compound Name |
N-[2-[(2S,4S)-2-Cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]naphthalene-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2022528; BDBM50382281
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[47] | |||
| Compound Name |
4-Phenyl-1-[(2S,4S)-4-[4-(phenylmethoxymethyl)triazol-1-yl]-2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl]butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2178970; BDBM50399727
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
3-[(7-But-2-ynyl-3-methyl-2,6-dioxo-8-piperazin-1-ylpurin-1-yl)methyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616905
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-3-methylbutanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2024674; BDBM50382256
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[47] | |||
| Compound Name |
2-Chloro-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]pyridine-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233555; BDBM50009335
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
(2S,3S)-3-Amino-4-(azetidin-1-yl)-2-[4-(4-fluorophenyl)phenyl]-N,N-dimethyl-4-oxobutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL370509
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[26] | |||
| Compound Name |
(2S,3S)-3-Amino-2-[4-(4-fluorophenyl)phenyl]-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxo-N-(tetrazol-1-yl)butanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL188444
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[26] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-1H-pyrrolo[2,3-b]pyridine-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233572; SCHEMBL15129831; BDBM50009352
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
(R)-3-Amino-4-(2,5-difluorophenyl)-1-(1-ethyl-2-(trifluoromethyl)-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL251405; BDBM50222486
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[28] | |||
| Compound Name |
2-[[7-But-2-ynyl-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]-2,6-dioxopurin-8-yl]amino]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616897
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(2S,3S)-3-Amino-2-[4-(4-fluorophenyl)phenyl]-4-[(3S)-3-fluoropyrrolidin-1-yl]-N-methoxy-N-methyl-4-oxobutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL370755
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[26] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-4-(trifluoromethoxy)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2022509; BDBM50382263
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[47] | |||
| Compound Name |
(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxo-2-[4-([1,2,4]triazolo[4,3-a]pyridin-6-yl)phenyl]butanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL207348
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[36] | |||
| Compound Name |
2-Bromo-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]pyridine-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233556; BDBM50009336
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
US9051329, Example 8
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3687983; SCHEMBL14554317; BDBM162383
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[50] | |||
| Compound Name |
4-Phenyl-1-[(2S,4S)-4-(4-pyridin-2-yltriazol-1-yl)-2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl]butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2178969; BDBM50399728
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
(2R,3S,5R)-2-(2,5-Difluorophenyl)-5-(2-methyl-4,6-dihydropyrrolo[3,4-d][1,3]oxazol-5-yl)oxan-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2425068; BDBM50440345
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[39] | |||
| Compound Name |
(2s,4s)-1-({(2s,4s)-4-[2-(1,3-Dihydro-2h-isoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidin-2-yl}carbonyl)-4-fluoropyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1243126; SCHEMBL3393518; BDBM50326390
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
N-[1-[(2S)-2-Cyanopyrrolidine-1-carbonyl]cyclopropyl]quinoline-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233541; BDBM50009316
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
(3R,4R)-1-([1,2,4]Triazolo[4,3-b]pyridazin-6-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-amine;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL231496
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
US9346814, Cmpd No 37 Example 42
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233566; SCHEMBL15129600; BDBM233324; BDBM50009347; N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]-1H-1,2,4-triazole-5-carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[45] | |||
| Compound Name |
1-(Quinazoline-2-ylmethyl)-3-methyl-7-(2-butynyl)-8-piperazinoxanthine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616900; BDBM50277317
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(2R,3S,5R)-2-(2,5-Difluorophenyl)-5-(2-ethylsulfonyl-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3735281; SCHEMBL18792879
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[29] | |||
| Compound Name |
trans-N-(2-(3-Chlorophenyl)cyclopropyl)-3-(2-((S)-2-cyanopyrrolidin-1-yl)-2-oxoethylamino)-3-methylbutanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1082996; BDBM50320123
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[52] | |||
| Compound Name |
2-[(3R)-4-[(3R)-3-Amino-4-(2,5-difluorophenyl)butanoyl]-3-methyl-2-oxo-1,4-diazepan-1-yl]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
1-substituted diazepanone 9c; CHEMBL231010; BDBM15531
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
(3R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,3-dimethyl-1,4-diazepan-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
1-substituted diazepanone 9e; CHEMBL231011; BDBM15534
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
(2S)-1-[2-(4-Phenyltriazol-1-yl)acetyl]pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233550; BDBM50009327
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
(2S)-1-(2-Naphthalen-1-yloxyacetyl)pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2385287; BDBM50434182
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[44] | |||
| Compound Name |
2-Amino-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]pyridine-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233557; BDBM50009337
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
2-(4-Chlorophenyl)-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2022507; BDBM50382262
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[47] | |||
| Compound Name |
(3R,4R)-1-([1,2,4]Triazolo[4,3-a]pyrimidin-7-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-amine;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL231294
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-5-methyl-1,4-diazepan-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
5-methyl diazepanone 13b; 5-methyl diazepanone 13a; CHEMBL397010; SCHEMBL5038119; BDBM15541
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-2-(4-imidazo[1,2-b]pyridazin-6-ylphenyl)-N,N-dimethyl-4-oxobutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL379702
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[36] | |||
| Compound Name |
1-[(2S,4R)-4-Azido-2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl]-4-phenylbutan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2178955; BDBM50399721
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
Tert-butyl 4-[1-[2-[[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]amino]-2-oxoethyl]triazol-4-yl]piperazine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2022522; BDBM50382275
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[47] | |||
| Compound Name |
(R)-3-Amino-4-(2-fluoro-phenyl)-1-((R)-2-thiazol-4-ylmethyl-piperazin-1-yl)-butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL185482; BDBM50151833
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
(2S)-1-[(2S,4S)-4-[2-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-oxoethyl]-5-oxopyrrolidine-2-carbonyl]pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242967; SCHEMBL3399176; BDBM50326380
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
N-[(4-Chlorophenyl)methyl]-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233544; BDBM50009319
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
(2S)-1-[{(2S,4S)-5-Oxo-4-(2-oxo-2-(piperidin-1-yl)ethyl)pyrrolidine-2-yl}carbonyl]pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1243092; BDBM50326388
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(2S)-1-[(2S,4S)-4-[2-(5-Fluoro-1,3-dihydroisoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidine-2-carbonyl]pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242940; SCHEMBL3399137; BDBM50326378
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
US9346814, Ref. Cmpd No 2
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3913191; BDBM233320
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[45] | |||
| Compound Name |
5-Chloro-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2385299; SCHEMBL15129952; BDBM50434170
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[45] | |||
| Compound Name |
(2S)-1-[2-[4-(4-Fluorophenyl)triazol-1-yl]acetyl]pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233551; BDBM50009328
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
(S)-2-Amino-2-cyclohexyl-1-(3,4-dihydroisoquinolin-2(1H)-YL)ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL361235; isoquinoline derivative 7; SCHEMBL14392751; BDBM12184; MB11304; (2S)-2-amino-2-cyclohexyl-1-(1,2,3,4-tetrahydroisoquinolin-2-yl)ethan-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[51] | |||
| Compound Name |
N-(2-Oxo-2-pyrrolidin-1-ylethyl)quinoline-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233846; BDBM50009368
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
3,4-Dihydro-1H-isoquinolin-2-yl-[(2S)-pyrrolidin-2-yl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL179996; ZINC11754398
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[51] | |||
| Compound Name |
(3R)-3-Amino-1-(6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL557187
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[38] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-N-cyclopropylquinoline-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233543; BDBM50009318
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
1-[(2S,4S)-4-Azido-2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl]-4-phenylbutan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2178978; BDBM50399743
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
(2S,3S)-3-Amino-2-[4-(4-fluorophenyl)phenyl]-4-[(3S)-3-fluoropyrrolidin-1-yl]-N',N'-dimethyl-4-oxobutanehydrazide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL371588
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[26] | |||
| Compound Name |
1-(2-Pyridylmethyl)-3-methyl-7-(2-butynyl)-8-(3-oxopiperazino)xanthine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616910
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
4-[(3R)-3-Amino-4-(2,5-difluorophenyl)butanoyl]-3-methyl-1,4-diazepan-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL427257
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
(3R,4R)-1-Pyridazin-3-yl-4-(2,4,5-trifluorophenyl)piperidin-3-amine;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL231090
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,4-diazepan-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Diazepanone Analog 22; 1,4-diazepan-2-one 2c; CHEMBL216643; BDBM13523
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-1,7-naphthyridine-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233833; SCHEMBL15129791; BDBM50009358
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[45] | |||
| Compound Name |
1-[(2S,4S)-4-[4-(4-Bromophenyl)triazol-1-yl]-2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl]-4-phenylbutan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2178967; BDBM50399730
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-N-methylquinoline-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233542; BDBM50009317
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
(3R)-3-Amino-1-[(5S,8S)-5,8-dimethyl-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL557219
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
1-[(2s,4s)-4-[4-(4-Fluorophenyl)-1,2,3-Triazol-1-Yl]-2-Pyrrolidin-1-Ylcarbonyl-Pyrrolidin-1-Yl]-4-Phenyl-Butan-1-One
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2178963; BDBM50399734; Q27466106
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
(2R,3S,5R)-2-(2,5-Difluorophenyl)-5-(3-methylsulfonyl-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3735917
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[29] | |||
| Compound Name |
N-[2-[(2S,4R)-4-Azido-2-cyanopyrrolidin-1-yl]-2-oxoethyl]naphthalene-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2022527; BDBM50382280
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[47] | |||
| Compound Name |
(R)-3-Amino-1-((R)-2-benzylpiperazin-1-yl)-4-(2-fluorophenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL175872; SCHEMBL5408217; BDBM50151843; (3R)-3-amino-1-[(2R)-2-benzylpiperazin-1-yl]-4-(2-fluorophenyl)butan-1-one; (R)-3-Amino-1-((R)-2-benzyl-piperazin-1-yl)-4-(2-fluoro-phenyl)-butan-1-one; 3-Amino-1-((R)-2-benzyl-piperazin-1-yl)-4-((R)-2-fluoro-phenyl)-butan-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
1-[4-(1H-Pyrazole-1-yl)benzyl]-3-methyl-7-(2-butynyl)-8-piperazinoxanthine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616908
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(2S)-1-[(2S)-2-Amino-4-{4-[bis(4-fluorophenyl)methyl]piperazin-1-yl}-4-oxobutanoyl]pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL362018; cyanopyrrolidine derivative 6; SCHEMBL14392630; BDBM12183
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(2s)-1-({(2s,4s)-4-[2-[4-(Pyridine-4-yl)-piperazin-1-yl]-2-oxoethyl]-5-oxopyrrolidin-2-yl}carbonyl)pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1243060; SCHEMBL3398698; BDBM50326385
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(2S)-1-[2-[4-[3-(1,3-Dihydroisoindol-2-yl)-3-oxopropyl]triazol-1-yl]acetyl]pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233552; BDBM50009329
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
Benzyl (2S,4S)-2-(pyrrolidine-1-carbonyl)-4-(triazol-1-yl)pyrrolidine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2178979; BDBM50399742
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
(2S)-2-Amino-2-phenyl-1-(1,2,3,4-tetrahydroisoquinolin-2-yl)ethan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
isoquinoline derivative 9; CHEMBL361758; BDBM12186
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[51] | |||
| Compound Name |
(3R)-3-Amino-1-[(8S)-8-methyl-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL557542
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
(3R)-3-Amino-1-[(3R)-3-benzylmorpholin-4-yl]-4-(2-fluorophenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL186610; SCHEMBL5407479; BDBM50151829; (R)-3-Amino-1-((R)-3-benzyl-morpholin-4-yl)-4-(2-fluoro-phenyl)-butan-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
N-[4-[(2S,3S)-3-Amino-1-(dimethylamino)-4-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxobutan-2-yl]phenyl]-N,4-dimethylbenzamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL396168
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
(R)-3-Amino-1-((S)-2-benzyl-piperidin-1-yl)-4-(2-fluoro-phenyl)-butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL186611; BDBM50151841
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
N-[5-[(3R,5S,6R)-5-Amino-6-(2,5-difluorophenyl)oxan-3-yl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]methanesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3734769; BDBM50134191
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[29] | |||
| Compound Name |
(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-2-[4-(1-methyl-6-oxopyridin-3-yl)phenyl]-4-oxobutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL209162
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[36] | |||
| Compound Name |
(3R,7S)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-methyl-7-(trifluoromethyl)-1,4-diazepan-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL230603
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
(1S,2R,5S)-5-(5H-Pyrrolo[3,4-d]pyrimidin-6(7H)-yl)-2-(2,4,5-trifluorophenyl)cyclohexanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL233564; BDBM50212925
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
CID 89704940
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233574; SCHEMBL15129575; BDBM50009356
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[45] | |||
| Compound Name |
(2S,3S)-2-[4-[Acetyl(methyl)amino]phenyl]-3-amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL246168
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
N-[5-[(3R,5S,6R)-5-Amino-6-(2,5-difluorophenyl)oxan-3-yl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3736135; BDBM50135020
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[29] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-3-methoxybenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2024673; BDBM50382288
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[47] | |||
| Compound Name |
(3R)-3-Amino-1-[(4S)-4-methyl-6-(trifluoromethyl)-3,4-dihydro-1H-pyrrolo[1,2-a]pyrazin-2-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2021541
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
(2S,3R,5S)-2-(2,5-Difluorophenyl)-5-(4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2425077; BDBM50440338
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[39] | |||
| Compound Name |
(R)-1-(2-(1-Oxoisoindolin-2-yl)acetyl)pyrrolidin-2-ylboronic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL387050; BDBM50200723
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
1-(4-Methoxyquinazoline-2-ylmethyl)-3-methyl-7-(2-butynyl)-8-(3-oxopiperazino)xanthine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616917
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(2S)-1-{2-[(3-{4-[(3,5-Difluorophenyl)carbonyl]piperazin-1-yl}-3-oxopropyl)amino]acetyl}pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL372746; SCHEMBL3554462; BDBM11701; (2S)-Cyanopyrrolidine analogue 18e
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
(2s)-1-({(2s,4s)-4-[2-(5-Chloro-1,3-dihydro-2h-isoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidin-2-yl}carbonyl)pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242939; SCHEMBL3395629; BDBM50326377
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-[[[(2S)-1-[3-Amino-4-(3,4-difluorophenyl)butanoyl]pyrrolidine-2-carbonyl]amino]methyl]benzoic acid;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL182223
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-4-thiophen-2-ylbenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2022512; BDBM50382266
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[47] | |||
| Compound Name |
(2R)-2-[4-[[[(2S)-1-[3-Amino-4-(2,3,4,5,6-pentafluorophenyl)butanoyl]pyrrolidine-2-carbonyl]amino]methyl]phenoxy]-3-methylbutanoic acid;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL183289
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
Benzyl (2S,4S)-4-azido-2-(pyrrolidine-1-carbonyl)pyrrolidine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2178977; BDBM50399744
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
(R)-3-Amino-4-phenyl-1-thiazolidin-3-yl-butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL184262; BDBM50151805; CHEMBL184262 (24)
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[31] | |||
| Compound Name |
(R)-3-Amino-1-((R)-2-benzyl-4-methyl-piperazin-1-yl)-4-(2-fluoro-phenyl)-butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL184071; SCHEMBL5439657; BDBM50151838; (3R)-3-amino-1-[(2R)-2-benzyl-4-methylpiperazin-1-yl]-4-(2-fluorophenyl)butan-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-2-[4-(5-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]-4-oxobutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL209111
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[36] | |||
| Compound Name |
N-[5-[(3R,5S,6R)-5-Amino-6-(2,5-difluorophenyl)oxan-3-yl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]cyclopropanecarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3734964; BDBM50134186
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[29] | |||
| Compound Name |
N-[4-[(2S,3S)-3-Amino-1-(dimethylamino)-4-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxobutan-2-yl]phenyl]-4-fluoro-N-methylbenzamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL245969
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-3-cyclopentyloxy-4-methoxybenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2022510; BDBM50382264
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[47] | |||
| Compound Name |
(3R)-3-Amino-1-[5,8-dimethyl-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL536089
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
(3R)-3-Amino-1-[(5R,8R)-5,8-dimethyl-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL536311
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
(3R,4R)-1-Pyrimidin-4-yl-4-(2,4,5-trifluorophenyl)piperidin-3-amine;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL230984
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
3-Amino-N-[4-[(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N-methylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683102; BDBM50338468; trans-3-amino-N-(4-((R)-1-amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)-N-methylpropanamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[18] | |||
| Compound Name |
N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N,2-dimethylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683100; BDBM50338466; trans-N-(4-((R)-1-amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)-N-methylisobutyramide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[18] | |||
| Compound Name |
(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-2-[4-[methyl-(4-methylphenyl)sulfonylamino]phenyl]-4-oxobutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL429653
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
N-[4-[(4-Acetamidophenoxy)-[2-[(2S,3R)-2-amino-3-methylpentanoyl]-1,3-dihydroisoindol-1-yl]phosphoryl]oxyphenyl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL238050; BDBM50225420; di-(4-acetamido)phenyl 2-((2S,3R)-2-amino-3-methylpentanoyl)isoindolin-1-ylphosphonate
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[35] | |||
| Compound Name |
(R)-3-Amino-4-(2,5-difluorophenyl)-1-(2-(trifluoromethyl)-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL402496; BDBM50222480
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[28] | |||
| Compound Name |
Methyl 2-[(3R)-4-[(3R)-3-amino-4-(2,5-difluorophenyl)butanoyl]-3-methyl-2-oxo-1,4-diazepan-1-yl]acetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
1-substituted diazepanone 9b; CHEMBL390884; BDBM15530
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
7-But-2-ynyl-3-methyl-8-(3-oxopiperazin-1-yl)-1-(pyridin-4-ylmethyl)purine-2,6-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616912
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(3R)-3-Amino-4-(3,4-difluorophenyl)-1-(6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL537625
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[38] | |||
| Compound Name |
1-[(4-Methoxyquinazolin-2-yl)methyl]-3-methyl-7-(4-methylpent-3-enyl)-8-(3-oxopiperazin-1-yl)purine-2,6-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616919
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(1S,2R,5S)-5-[3-(Trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-A]pyrazin-7(8H)-YL]-2-(2,4,5-trifluorophenyl)cyclohexanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL233360; SCHEMBL3904882; BDBM50212927; CHEMBL233360 (15); DB07072; Q27095987
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
(2R,3S,5R)-2-(2,5-Difluorophenyl)-5-(2-propylsulfonyl-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3734912
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[29] | |||
| Compound Name |
(3R)-3-Amino-4-(2,5-difluorophenyl)-1-[3-(trifluoromethyl)-4H,5H,6H,7H-pyrido[3,4-c][1,2]oxazol-6-yl]butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
isoxazolopiperidine 64; CHEMBL195984; BDBM11962
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
(2S,3S)-3-Amino-2-[4-(4-fluorophenyl)phenyl]-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL191208
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[26] | |||
| Compound Name |
(2R)-1-[2-[2-[3-(3,4-Dimethoxyphenyl)-2-oxoimidazolidin-1-yl]ethylamino]acetyl]pyrrolidine-2-carbonitrile;oxalic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1202080
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[55] | |||
| Compound Name |
(2S,3S,5S)-2-(2,5-Difluorophenyl)-5-(4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2425080; BDBM50440336
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[39] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-5-methoxyquinoline-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233839; SCHEMBL15129973; BDBM50009363
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
7-[(3R,4R)-3-Amino-4-(2,4,5-trifluorophenyl)piperidin-1-yl]pyrimido[1,2-b]pyridazin-2-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL231396
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
2-({2-[(3r)-3-Aminopiperidin-1-Yl]-5-Methyl-6,9-Dioxo-5,6,7,9-Tetrahydro-1h-Imidazo[1,2-A]purin-1-Yl}methyl)-4-Fluorobenzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3687984; SCHEMBL14554320; Q27456296; 6AJ
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[50] | |||
| Compound Name |
(S)-N-(2-(2-Cyanopyrrolidine-1-yl)-2-oxoethyl)-5-phenylquinoline-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233838; SCHEMBL15129619; BDBM50009362; N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]-5-phenylquinoline-4-carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[45] | |||
| Compound Name |
(4-{[4-(Ethoxycarbonylmethyl-carbamoyl)-phenoxy]-[1-(pyrrolidine-2-carbonyl)-pyrrolidin-2-yl]-phosphinoyloxy}-benzoylamino)-acetic acid ethyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL235766; BDBM50225430
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[35] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]isoquinoline-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2385278; BDBM50434191
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[44] | |||
| Compound Name |
(2R,3R)-2-Amino-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazole-7-carboxylic acid;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL563383
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
(3S)-2-[(2S)-2-Amino-2-cyclohexylacetyl]-3,4-dihydro-1H-isoquinoline-3-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL361551; SCHEMBL14392398
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[51] | |||
| Compound Name |
(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4-fluoro-2-(trifluoromethyl)phenyl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL191652
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[33] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopiperidin-1-yl]-2-oxoethyl]naphthalene-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2022535; BDBM50382286
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[47] | |||
| Compound Name |
N-[2-[(2S)-2-Cyano-4,4-difluoropyrrolidin-1-yl]-2-oxoethyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2022529; BDBM50382282
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[47] | |||
| Compound Name |
2,2,2-Trifluoroacetic acid;(3R,4R)-1-[2-(trifluoromethyl)-[1,2,4]triazolo[1,5-b]pyridazin-6-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL231293
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
US9051329, Example 3
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3687979; SCHEMBL14554368; BDBM162378
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[50] | |||
| Compound Name |
2-((R)-2-Amino-4-oxo-4-thiazolidin-3-yl-butyl)-benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL185121; BDBM50151800
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[31] | |||
| Compound Name |
(R)-3-Amino-4-(2-fluoro-phenyl)-1-((R)-2-pyridin-3-ylmethyl-piperazin-1-yl)-butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL184808; BDBM50151820
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
N-((R)-1-((S)-2-Cyanopyrrolidine-1-yl)-1-oxopropan-2-yl)quinoline-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233539; SCHEMBL15129971; BDBM50009314; N-[(2R)-1-[(2S)-2-cyanopyrrolidin-1-yl]-1-oxopropan-2-yl]quinoline-4-carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[45] | |||
| Compound Name |
N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N,1-dimethylimidazole-4-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683087; BDBM50338453
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[18] | |||
| Compound Name |
(3R)-3-Amino-1-(4-cyclopropyl-1-methyl-2-(trifluoromethyl)-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL248810; BDBM50222469
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[28] | |||
| Compound Name |
2-[3-[2-[2-Cyano-(S)-pyrrolidin-1-yl]-2-oxoethylamino]-4-methyl-1-oxopentyl]-1,2,3,4-tetrahydroisoquinoline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL201398; BDBM11715; (2S)-Cyanopyrrolidine analogue 20b
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
7-But-2-ynyl-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]-8-piperidin-1-ylpurine-2,6-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616892; SCHEMBL15083818
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(2R)-2-[4-[[[(2S)-1-[3-Amino-4-(2,5-difluorophenyl)butanoyl]pyrrolidine-2-carbonyl]amino]methyl]phenoxy]-3-methylbutanoic acid;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL364102
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
(2S,4S)-1-[(2S)-2-Amino-3-[2-(trifluoromethyl)phenyl]propanoyl]-4-fluoropyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3093912; BDBM50443747
Click to Show/Hide
|
||||
| Activity |
IC50 = 102000 nM
|
[42] | |||
| Compound Name |
1-Pentanone, 2-amino-3-methyl-1-(1-pyrrolidinyl)-, (2S,3S)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL503274; isoleucyl-pyrrolidine; 1-(L-Ile-)Pyrrolidine; SCHEMBL355114; BDBM50118943; ZINC11959221; (2S,3S)-2-amino-3-methyl-1-pyrrolidin-1-ylpentan-1-one; (2S,3S)-2-amino-3-methyl-1-(pyrrolidin-1-yl)pentan-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 110000 nM
|
[22] | |||
| Compound Name |
Ala-Pro-CN
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL319514; SCHEMBL14392760; BDBM50118940; (2S)-1-L-Alanyl-2alpha-pyrrolidinecarbonitrile; (S)-1-((S)-2-Amino-propionyl)-pyrrolidine-2-carbonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 = 110000 nM
|
[20] | |||
| Compound Name |
2-Amino-1-(3-fluoro-pyrrolidin-1-yl)-3-methyl-pentan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL148261; BDBM50135074; 2-amino-1-(3-fluoropyrrolidin-1-yl)-3-methylpentan-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 111000 nM
|
[20] | |||
| Compound Name |
(2S,3S)-2-Amino-1-(3-fluoropyrrolidin-1-yl)-3-methylpentan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL460886; SCHEMBL8198092; BDBM50243555
Click to Show/Hide
|
||||
| Activity |
IC50 = 111000 nM
|
[22] | |||
| Compound Name |
(S)-2-Amino-4-methyl-1-(pyrrolidin-1-yl)pentan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL453574; SCHEMBL7817249; BDBM50243408; ZINC11960880; (2S)-1-Pyrrolizino-2-amino-4-methyl-1-pentanone
Click to Show/Hide
|
||||
| Activity |
IC50 = 122000 nM
|
[22] | |||
| Compound Name |
(3S)-3-Amino-4-(2-diphenoxyphosphorylpyrrolidin-1-yl)-4-oxo-butanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL237672; Compound 10.2; BDBM98042
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 125000 nM
|
[35] | |||
| Compound Name |
Talabostat
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Val-boro-pro; PT-100; UNII-KZ1O2SH88Z; Val-boroPro; KZ1O2SH88Z; CHEMBL67279; Pyrrolidine derivative; PT100; [(2R)-1-[(2S)-2-amino-3-methylbutanoyl]pyrrolidin-2-yl]boronic acid; ((R)-1-(L-Valyl)pyrrolidin-2-yl)boronic acid; Talabostat(PT100); Talabostat [USAN:INN]; PT 100; ValboroPro; ((2R)-1-((2S)-2-amino-3-methylbutanoyl)pyrrolidin-2-yl)boronic acid; Boronic acid, ((2R)-1-((2S)-2-amino-3-methyl-1-oxobutyl)-2-pyrrolidinyl)-; Boronic acid, [(2R)-1-[(2S)-2-amino-3-methyl-1-oxobutyl]-2-pyrrolidinyl]-; Valinyl-L-Boroproline; Ketopyrrolidine derivative; Talabostat (USAN/INN); SCHEMBL393024; C9H19BN2O3; GTPL9892; CTK0H0433; EX-A3155; ((R)-1-((S)-2-Amino-3-methylbutanoyl)pyrrolidin-2-yl)boronic acid; 8274AH; BDBM50050513; ZINC169746694; compound 1 [PMID: 18783201]; CS-6996; DB06182; HY-13233; A18222; D05989; (2R)-1-(L-Valyl)-2alpha-(dihydroxyboryl)pyrrolidine; Q27282515; (R)-1-((S)-2-amino-3-methylbutanoyl)pyrrolidin-2-ylboronic acid; (S)-2-Amino-3-methyl-2-boronic acid-1-pyrrolidin-1-yl-butan-1-one; [(2R)-1-[(2S)-2-Amino-3-methyl-1-oxobutyl]-2-pyrrolidinyl]boronic acid; (S)-2-Amino-1-((R)-2-dihydroxyboron-pyrrolidin-1-yl)-3-methyl-butan-1-one; Boronic acid, (1-(2-amino-3-methyl-1-oxobutyl)-2-pyrrolidinyl)-, (R-(R*,S*))-
Click to Show/Hide
|
||||
| Activity |
Ki = 125000 nM
|
[20] | |||
| Compound Name |
(2S,4S)-1-[(3R)-3-Amino-4-(2-chlorophenyl)butanoyl]-4-fluoropyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3330050; BDBM50098910
Click to Show/Hide
|
||||
| Activity |
IC50 = 129710 nM
|
[17] | |||
| Compound Name |
(R)-2,4-Diamino-1-piperidin-1-yl-butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL146450; SCHEMBL6820919; BDBM50135075; (2R)-2,4-diamino-1-piperidin-1-ylbutan-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 130000 nM
|
[20] | |||
| Compound Name |
(1R)-2-[2-(1-Adamantylamino)acetyl]cyclopentane-1-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL179771
Click to Show/Hide
|
||||
| Activity |
IC50 = 133500 nM
|
[21] | |||
| Compound Name |
Cyclohexyl-(2-pyrrolidino-ethyl)-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL177735; SCHEMBL3446318; AKOS009012969; N-(2-pyrrolidin-1-ylethyl)cyclohexanamine
Click to Show/Hide
|
||||
| Activity |
IC50 = 136000 nM
|
[21] | |||
| Compound Name |
Pyrrolidine, 1-[(2S,3R)-2-amino-3-methyl-1-oxopentyl]-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL453573; SCHEMBL297708; CTK0A6989; DTXSID90430756; BDBM50243407; ZINC11959217; (2S,3R)-2-amino-3-methyl-1-(pyrrolidin-1-yl)pentan-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 145000 nM
|
[22] | |||
| Compound Name |
2-[[(2S,4S)-1-[(1,1-Dimethyl-2-hydroxyethylamino)acetyl]-4-fluoro-2-pyrrolidinyl]carbonyl]-5-tert-butyl-1,3,4-oxadiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL232185; BDBM50214709
Click to Show/Hide
|
||||
| Activity |
IC50 = 145800 nM
|
[34] | |||
| Compound Name |
2-Amino-3-(4-hydroxy-phenyl)-1-pyrrolidin-1-yl-propan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL317126; BDBM50118937
Click to Show/Hide
|
||||
| Activity |
IC50 = 150000 nM
|
[20] | |||
| Compound Name |
3-Amino-4-oxo-4-pyrrolidin-1-yl-butyramide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL328795; BDBM50118948
Click to Show/Hide
|
||||
| Activity |
IC50 = 152000 nM
|
[20] | |||
| Compound Name |
(S)-3-Amino-4-oxo-4-(pyrrolidin-1-yl)butanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL443373; BDBM50243452
Click to Show/Hide
|
||||
| Activity |
IC50 = 152000 nM
|
[22] | |||
| Compound Name |
2-Amino-3-methyl-1-pyrrolidin-1-YL-butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
(S)-2-amino-3-methyl-1-(pyrrolidin-1-yl)butan-1-one; CHEMBL383705; (2S)-2-amino-3-methyl-1-(pyrrolidin-1-yl)butan-1-one; (2S)-2-amino-3-methyl-1-pyrrolidin-1-ylbutan-1-one; Pyrrolidine, 1-[(2S)-2-amino-3-methyl-1-oxobutyl]-; valine-pyrrolidide; 1-valylpyrrolidine; SCHEMBL111112; ZINC7335; CTK1F9393; DTXSID50332247; BDBM50178428; MFCD09724545; AKOS010391077; DB01884; MCULE-4089760641; NS-01392; (2S)-3-methyl-1-oxo-1-pyrrolidin-1-ylbutan-2-amine; Q27093003; F8881-8952
Click to Show/Hide
|
||||
| Activity |
IC50 = 153000 nM
|
[56] | |||
| Compound Name |
Benzoic acid 1-(2-amino-3-methyl-pentanoyl)-pyrrolidin-3-yl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL148026; BDBM50135067
Click to Show/Hide
|
||||
| Activity |
IC50 = 158000 nM
|
[20] | |||
| Compound Name |
2,6-Diamino-1-azetidin-1-yl-hexan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL348246; BDBM50135052
Click to Show/Hide
|
||||
| Activity |
IC50 = 159000 nM
|
[20] | |||
| Compound Name |
2-(Cyclohexylamino)-1-(piperidin-1-yl)ethan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Amide Analogue 34; CHEMBL177696; BDBM12452; 15.2a; ZINC13611630; AKOS000253191; N-Cyclohexyl-2-oxo-2-(1-piperidinyl)ethaneamine
Click to Show/Hide
|
||||
| Activity |
IC50 = 177000 nM
|
[21] | |||
| Compound Name |
(S)-2-Amino-1-(pyrrolidin-1-yl)propan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL443622; (2S)-2-amino-1-pyrrolidin-1-ylpropan-1-one; Pyrrolidine, 1-[(2S)-2-amino-1-oxopropyl]-; (2S)-2-amino-1-(pyrrolidin-1-yl)propan-1-one; l-alanine pyrrolidide; 1-(L-Ala-)Pyrrolidine; SCHEMBL389573; CTK1F4743; DTXSID20464286; BDBM50243406; ZINC11957328; AKOS010386702; MCULE-7219811454; NS-01098
Click to Show/Hide
|
||||
| Activity |
IC50 = 179000 nM
|
[22] | |||
| Compound Name |
2,4-Diamino-1-piperidin-1-yl-butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL147923; SCHEMBL1063047; BDBM50135044
Click to Show/Hide
|
||||
| Activity |
IC50 = 191000 nM
|
[20] | |||
| Compound Name |
(2S,4S)-1-[(3R)-3-Amino-4-(4-fluorophenyl)butanoyl]-4-fluoropyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3330053; BDBM50098907
Click to Show/Hide
|
||||
| Activity |
IC50 = 192790 nM
|
[17] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 33 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Vildagliptin/metformin
Click to Show/Hide
|
Phase 3 | Compound Info | ||
| Synonyms |
274901-16-5; (S)-1-[2-((5S,7S)-3-hydroxy-adamantan-1-ylamino)-acetyl]-pyrrolidine-2-carbonitrile; 1044676-63-2; vildaglipitin; (-)-(2S)-1-[[(3-Hydroxytricyclo[3.3.1.1[3,7]]dec-1-yl)amino]acetyl]pyrrolidine-2-carbonitrile; (S)-1-[N-(3-hydroxy-1-adamantyl)glycyl]pyrrolidine-2-carbonitrile; CHEMBL319819; SCHEMBL16155482; SCHEMBL16153676; SCHEMBL10031674; CHEMBL3084811; MolPort-020-006-001; (S)-1-(2-(((1r,3R,5R,7S)-3-hydroxyadamantan-1-yl)amino)acetyl)pyrrolidine-2-carbonitrile; BDBM123776
Click to Show/Hide
|
||||
| Activity |
IC50 = 210000 nM
|
[6] | |||
| Compound Name |
(S)-pyrrolidin-1-yl(pyrrolidin-2-yl)methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL403882; L-Prolin-pyrrolidid; (S)-1-prolylpyrrolidine; 1-(L-Prolyl)pyrrolidine; (S)-pyrrolidin-1-yl(pyrrolidin-2-yl)methanone; 41721-00-0; SCHEMBL1383434; HDLWINONZUFKQV-QMMMGPOBSA-N; ZINC11754367; BDBM50228295; AKOS022180332; AJ-60015; Pyrrolidine, 1-[(2S)-2-pyrrolidinylcarbonyl
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[22] | |||
| Compound Name |
N-[[(2S,3As,7aS)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-2,3,3a,4,5,6,7,7a-octahydroindol-2-yl]methyl]-1,1,1-trifluoromethanesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3357782; BDBM50037682
Click to Show/Hide
|
||||
| Activity |
IC50 = 207350 nM
|
[2] | |||
| Compound Name |
2-Amino-3-methyl-pentanoic acid methyl-propyl-amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL343650; BDBM50135076
Click to Show/Hide
|
||||
| Activity |
IC50 = 213000 nM
|
[20] | |||
| Compound Name |
2-Amino-1-azepan-1-yl-3-methyl-pentan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL148127; BDBM50135046; AKOS000187601
Click to Show/Hide
|
||||
| Activity |
IC50 = 228000 nM
|
[20] | |||
| Compound Name |
1-Isoleucylhexahydro-1H-azepine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL446007; BDBM50243498; ZINC13529436; (2S,3S)-2-amino-1-(azepan-1-yl)-3-methylpentan-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 228000 nM
|
[22] | |||
| Compound Name |
(2S,3R)-2-Amino-3-hydroxy-1-(pyrrolidin-1-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL459438; SCHEMBL15924487; BDBM50243453; (2S,3R)-2-amino-3-hydroxy-1-pyrrolidin-1-ylbutan-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 230000 nM
|
[22] | |||
| Compound Name |
Benzyl N-[(2S)-6-amino-1-[1-bis(4-acetamidophenoxy)phosphoryl-1,3-dihydroisoindol-2-yl]-1-oxohexan-2-yl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL392163; BDBM50225424; benzyl (S)-5-amino-6-(1-(di-(4-acetamido)phenoxyphosphoryl)isoindolin-2-yl)-6-
Click to Show/Hide
|
||||
| Activity |
IC50 > 250000 nM
|
[35] | |||
| Compound Name |
Diphenyl 2-((2S,3S)-2-amino-3-methylpentanoyl)isoindolin-1-ylphosphonate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL399402; BDBM50225435
Click to Show/Hide
|
||||
| Activity |
IC50 > 250000 nM
|
[35] | |||
| Compound Name |
2-(Benzylamino)-1-cyclopentylethanethione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL178844
Click to Show/Hide
|
||||
| Activity |
IC50 > 250000 nM
|
[21] | |||
| Compound Name |
Diphenyl 2-((2S,3R)-2-amino-3-methylpentanoyl)isoindolin-1-ylphosphonate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL237860; BDBM50225422
Click to Show/Hide
|
||||
| Activity |
IC50 > 250000 nM
|
[35] | |||
| Compound Name |
Ethanone, 2-(cyclohexylamino)-1-(1-pyrrolidinyl)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Amide Analogue 25; cyclohexylglycine pyrrolidide; CHEMBL177746; SCHEMBL5325757; BDBM12443; 15.1a; AKOS000253189; N-Cyclohexyl-2-oxo-2-(1-pyrrolidinyl)ethaneamine; 2-(cyclohexylamino)-1-(pyrrolidin-1-yl)ethan-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 276000 nM
|
[21] | |||
| Compound Name |
2-Amino-1-(2,5-dihydro-pyrrol-1-yl)-3-methyl-pentan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL148569; BDBM50135072
Click to Show/Hide
|
||||
| Activity |
IC50 = 288000 nM
|
[20] | |||
| Compound Name |
1-Isoleucyl-3-pyrroline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL461291; BDBM50243499; (2S,3S)-2-amino-1-(2,5-dihydropyrrol-1-yl)-3-methylpentan-1-one; (2S,3S)-2-amino-3-methyl-1-(2H-pyrrol-1(5H)-yl)pentan-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 288000 nM
|
[22] | |||
| Compound Name |
(2S)-1-[(2S)-2-Amino-3-(2-fluorophenyl)propanoyl]pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3093916; BDBM50443742
Click to Show/Hide
|
||||
| Activity |
IC50 = 296900 nM
|
[42] | |||
| Compound Name |
2-Amino-1-(3-hydroxy-pyrrolidin-1-yl)-3-methyl-pentan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL147691; BDBM50135081; AKOS012239185
Click to Show/Hide
|
||||
| Activity |
IC50 = 299000 nM
|
[20] | |||
| Compound Name |
(2S,3S)-2-Amino-1-(3-hydroxypyrrolidin-1-yl)-3-methylpentan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL503809; BDBM50243553; AKOS012240510
Click to Show/Hide
|
||||
| Activity |
IC50 = 299000 nM
|
[22] | |||
| Compound Name |
(S)-Benzyl 5-amino-6-(3,4-dihydroquinolin-1(2H)-yl)-6-oxohexylcarbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL512705; BDBM50243647
Click to Show/Hide
|
||||
| Activity |
IC50 = 390000 nM
|
[22] | |||
| Compound Name |
(S)-2,6-Diamino-1-(3,4-dihydroquinolin-1(2H)-yl)hexan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL449318; BDBM50243606
Click to Show/Hide
|
||||
| Activity |
IC50 = 393000 nM
|
[22] | |||
| Compound Name |
Piperidine, 1-[[(phenylmethyl)amino]acetyl]-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Amide Analogue 35; ACMC-20m3xj; 2-(benzylamino)-1-piperidin-1-ylethanone; CHEMBL176262; BDBM12453; CTK0G8583; DTXSID00472369; 15.2b; ZINC13611632; AKOS000251939; AKOS002995184; N-Benzyl-2-oxo-2-(1-piperidinyl)ethaneamine; 2-(benzylamino)-1-(piperidin-1-yl)ethan-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 397000 nM
|
[21] | |||
| Compound Name |
(6S)-1-[(2S)-2-Amino-4-[2-(2-methoxyethyl)-4-(trifluoromethyl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-7-yl]-4-oxobutyl]-5,5-difluoro-6-hydroxypiperidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3644790; SCHEMBL13099358; BDBM97583; US8470836, 10
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
2-Amino-3-methyl-pentanoic acid cyclopentylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL148142; BDBM50135077; AKOS000186824
Click to Show/Hide
|
||||
| Activity |
IC50 = 500000 nM
|
[20] | |||
| Compound Name |
(S)-3-Amino-4-oxo-4-(pyrrolidin-1-yl)butanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL499101; BDBM50243412
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[22] | |||
| Compound Name |
Diphenyl 1-((2S,3S)-2-amino-3-methylpentanoyl)pyrrolidin-2-ylphosphonate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL427850; BDBM50225427
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[35] | |||
| Compound Name |
Fluoro-Olefin Analogue 9
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
9.8a; CHEMBL275472; BDBM12427; N-(2-cyclohexylidene-2-fluoroethyl)cyclohexanamine; N-(2-Cyclohexylidene-2-fluoroethyl)cyclohexan-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 500000 nM
|
[21] | |||
| Compound Name |
2-Amino-3-methyl-pentanoic acid diethylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL146437; BDBM50135049; AKOS000170515
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[20] | |||
| Compound Name |
2-(Benzylamino)-1-(pyrrolidin-1-yl)ethan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Amide Analogue 26; CHEMBL175260; SCHEMBL10381350; BDBM12444; 15.1b; ZINC13611615; AKOS000251889; 2-(benzylamino)-1-pyrrolidin-1-ylethanone; N-Benzyl-2-oxo-2-(1-pyrrolidinyl)ethaneamine
Click to Show/Hide
|
||||
| Activity |
IC50 = 500000 nM
|
[21] | |||
| Compound Name |
Pyrrolidin-1-yl-(tetrahydro-thiophen-2-yl)-methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL343907; BDBM50135064; AKOS013916174
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[20] | |||
| Compound Name |
Pyrrolidin-2-yl-pyrrolidin-1-yl-methanethione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL328655; BDBM50118954
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[57] | |||
| Compound Name |
Benzyl (S)-6-amino-1-(2-(diphenoxyphosphoryl)pyrrolidin-1-yl)-1-oxohexan-2-ylcarbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL439205; BDBM50225433
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[35] | |||
| Compound Name |
2-Amino-3-methyl-pentanoic acid ethyl-methyl-amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL434886; BDBM50135084
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[20] | |||
| Compound Name |
1-Isoleucylazetidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL461496; CTK0A1560; DTXSID80442363; BDBM50243496; (2S,3S)-2-amino-1-(azetidin-1-yl)-3-methylpentan-1-one; Azetidine, 1-[(2S,3S)-2-amino-3-methyl-1-oxopentyl]-
Click to Show/Hide
|
||||
| Activity |
IC50 = 730000 nM
|
[22] | |||
| Compound Name |
2-Amino-1-azetidin-1-yl-3-methyl-pentan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL346877; BDBM50135061
Click to Show/Hide
|
||||
| Activity |
IC50 = 730000 nM
|
[20] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Substituted 4-carboxymethylpyroglutamic acid diamides as potent and selective inhibitors of fibroblast activation protein. J Med Chem. 2010 Sep 23;53(18):6572-83. | ||||
| REF 2 | (R)-3-amino-1-((3aS,7aS)-octahydro-1H-indol-1-yl)-4-(2,4,5-trifluorophenyl)butan-1-one derivatives as potent inhibitors of dipeptidyl peptidase-4: design, synthesis, biological evaluation, and molecular modeling. Bioorg Med Chem. 2014 Dec 1;22(23):6684-6693. | ||||
| REF 3 | Selective inhibitors of fibroblast activation protein (FAP) with a xanthine scaffold. Medchemcomm. 2014;5:1700-7. | ||||
| REF 4 | Discovery and pharmacological characterization of N-[2-({2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl}amino)-2-methylpropyl]-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide hydrochloride (anagliptin hydrochloride salt) as a potent and selective DPP-IV inhibitor. Bioorg Med Chem. 2011 Dec 1;19(23):7221-7. | ||||
| REF 5 | Omarigliptin (MK-3102): a novel long-acting DPP-4 inhibitor for once-weekly treatment of type 2 diabetes. J Med Chem. 2014 Apr 24;57(8):3205-12. | ||||
| REF 6 | 1-[[(3-hydroxy-1-adamantyl)amino]acetyl]-2-cyano-(S)-pyrrolidine: a potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitor with antihyperglycemic properties. J Med Chem. 2003 Jun 19;46(13):2774-89. | ||||
| REF 7 | Probing for improved selectivity with dipeptide-derived inhibitors of dipeptidyl peptidases 8 and 9: the impact of P1-variation. Medchemcomm. 2016;7:433-8. | ||||
| REF 8 | 2-[3-[2-[(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethylamino]-3-methyl-1-oxobutyl]- 1,2,3,4-tetrahydroisoquinoline: a potent, selective, and orally bioava... J Med Chem. 2006 Jan 12;49(1):373-80. | ||||
| REF 9 | Extended structure-activity relationship and pharmacokinetic investigation of (4-quinolinoyl)glycyl-2-cyanopyrrolidine inhibitors of fibroblast activation protein (FAP). J Med Chem. 2014 Apr 10;57(7):3053-74. | ||||
| REF 10 | Inhibitors of dipeptidyl peptidase 8 and dipeptidyl peptidase 9. Part 2: isoindoline containing inhibitors. Bioorg Med Chem Lett. 2008 Jul 15;18(14):4159-62. | ||||
| REF 11 | 2-({6-[(3R)-3-amino-3-methylpiperidine-1-yl]-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-5H-pyrrolo[3,2-d]pyrimidine-5-yl}methyl)-4-fluorobenzonitrile (DSR-12727): a potent, orally active dipeptidyl peptidase IV inhibitor without mechanism-based inactivation of CYP3A. Bioorg Med Chem. 2011 Sep 15;19(18):5490-9. | ||||
| REF 12 | Structure-activity relationship studies on isoindoline inhibitors of dipeptidyl peptidases 8 and 9 (DPP8, DPP9): is DPP8-selectivity an attainable goal?. J Med Chem. 2011 Aug 25;54(16):5737-46. | ||||
| REF 13 | US patent application no. 8470836B2, Dipeptidyl peptidase-IV inhibiting compounds, methods of preparing the same, and pharmaceutical compositions containing the same as active agent | ||||
| REF 14 | Diastereoselective synthesis and configuration-dependent activity of (3-substituted-cycloalkyl)glycine pyrrolidides and thiazolidides as dipeptidyl peptidase IV inhibitors. Bioorg Med Chem Lett. 2004 Feb 23;14(4):859-63. | ||||
| REF 15 | Substituted piperazines as novel dipeptidyl peptidase IV inhibitors. Bioorg Med Chem Lett. 2004 Sep 20;14(18):4763-6. | ||||
| REF 16 | Discovery of 3-aminopiperidines as potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitors. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4579-83. | ||||
| REF 17 | Design, synthesis and biological evaluation of 4-fluoropyrrolidine-2-carbonitrile and octahydrocyclopenta[b]pyrrole-2-carbonitrile derivatives as dipeptidyl peptidase IV inhibitors. Eur J Med Chem. 2014 Oct 30;86:242-56. | ||||
| REF 18 | Synthesis and evaluation of [(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]cyclohexanes and 4-[(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]piperidines as DPP-4 inhibitors. Bioorg Med Chem Lett. 2011 Mar 15;21(6):1880-6. | ||||
| REF 19 | Dipeptidyl peptidase IV inhibitors derived from beta-aminoacylpiperidines bearing a fused thiazole, oxazole, isoxazole, or pyrazole. Bioorg Med Chem Lett. 2005 May 2;15(9):2253-8. | ||||
| REF 20 | Design, synthesis, and SAR of potent and selective dipeptide-derived inhibitors for dipeptidyl peptidases. J Med Chem. 2003 Nov 6;46(23):5005-14. | ||||
| REF 21 | Fluoro-olefins as peptidomimetic inhibitors of dipeptidyl peptidases. J Med Chem. 2005 Mar 24;48(6):1768-80. | ||||
| REF 22 | Inhibitors of dipeptidyl peptidase 8 and dipeptidyl peptidase 9. Part 1: identification of dipeptide derived leads. Bioorg Med Chem Lett. 2008 Jul 15;18(14):4154-8. | ||||
| REF 23 | Discovery of potent and selective dipeptidyl peptidase IV inhibitors derived from beta-aminoamides bearing subsituted triazolopiperazines. J Med Chem. 2008 Feb 14;51(3):589-602. | ||||
| REF 24 | Design, synthesis, and biological evaluation of triazolopiperazine-based beta-amino amides as potent, orally active dipeptidyl peptidase IV (DPP-4) inhibitors. Bioorg Med Chem Lett. 2007 Nov 1;17(21):5934-9. | ||||
| REF 25 | Aminopiperidine-fused imidazoles as dipeptidyl peptidase-IV inhibitors. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4097-101. | ||||
| REF 26 | Discovery of potent and selective orally bioavailable beta-substituted phenylalanine derived dipeptidyl peptidase IV inhibitors. Bioorg Med Chem Lett. 2005 Jun 15;15(12):3048-52. | ||||
| REF 27 | Potent and selective proline derived dipeptidyl peptidase IV inhibitors. Bioorg Med Chem Lett. 2004 Oct 18;14(20):5151-5. | ||||
| REF 28 | Imidazopiperidine amides as dipeptidyl peptidase IV inhibitors for the treatment of diabetes. Bioorg Med Chem Lett. 2007 Nov 1;17(21):5853-7. | ||||
| REF 29 | Structure-activity-relationship of amide and sulfonamide analogs of omarigliptin. Bioorg Med Chem Lett. 2015 Dec 15;25(24):5767-71. | ||||
| REF 30 | Optimization of 1,4-diazepan-2-one containing dipeptidyl peptidase IV inhibitors for the treatment of type 2 diabetes. Bioorg Med Chem Lett. 2007 Apr 1;17(7):1903-7. | ||||
| REF 31 | Discovery of potent and selective beta-homophenylalanine based dipeptidyl peptidase IV inhibitors. Bioorg Med Chem Lett. 2004 Sep 20;14(18):4759-62. | ||||
| REF 32 | (3R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one, a selective dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. Bioorg Med Chem Lett. 2007 Jan 1;17(1):49-52. | ||||
| REF 33 | Discovery of potent and selective phenylalanine based dipeptidyl peptidase IV inhibitors. Bioorg Med Chem Lett. 2005 May 16;15(10):2533-6. | ||||
| REF 34 | Synthesis, SAR, and X-ray structure of novel potent DPPIV inhibitors: oxadiazolyl ketones. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4167-72. | ||||
| REF 35 | Irreversible inhibition of dipeptidyl peptidase 8 by dipeptide-derived diaryl phosphonates. J Med Chem. 2007 Nov 15;50(23):5568-70. | ||||
| REF 36 | (2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(4-[1,2,4]triazolo[1,5-a]-pyridin-6-ylphenyl)butanamide: a selective alpha-amino amide dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. J Med Chem. 2006 Jun 15;49(12):3614-27. | ||||
| REF 37 | Modeling assisted rational design of novel, potent, and selective pyrrolopyrimidine DPP-4 inhibitors. Bioorg Med Chem Lett. 2007 Jul 15;17(14):3877-9. | ||||
| REF 38 | (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: a potent, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. J Med Chem. 2005 Jan 13;48(1):141-51. | ||||
| REF 39 | Novel tetrahydropyran analogs as dipeptidyl peptidase IV inhibitors: Profile of clinical candidate (2R,3S,5R)-2- (2,5-difluorophenyl)-5-(4,6-dihydropyrrolo [3,4-c]pyrazol-5-(1H)-yl)tetrahydro-2H-pyran-3-amine (23) [corrected]. Bioorg Med Chem Lett. 2013 Oct 1;23(19):5361-6. | ||||
| REF 40 | 4-aminophenylalanine and 4-aminocyclohexylalanine derivatives as potent, selective, and orally bioavailable inhibitors of dipeptidyl peptidase IV. Bioorg Med Chem Lett. 2007 May 15;17(10):2879-85. | ||||
| REF 41 | Synthesis, biological evaluation and structural determination of beta-aminoacyl-containing cyclic hydrazine derivatives as dipeptidyl peptidase IV (DPP-IV) inhibitors. Bioorg Med Chem Lett. 2007 May 1;17(9):2622-8. | ||||
| REF 42 | Synthesis and biological evaluation of pyrrolidine-2-carbonitrile and 4-fluoropyrrolidine-2-carbonitrile derivatives as dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes. Bioorg Med Chem. 2013 Dec 1;21(23):7418-29. | ||||
| REF 43 | Novel series of 3-amino-N-(4-aryl-1,1-dioxothian-4-yl)butanamides as potent and selective dipeptidyl peptidase IV inhibitors. Bioorg Med Chem Lett. 2012 Dec 1;22(23):7036-40 | ||||
| REF 44 | Selective Inhibitors of Fibroblast Activation Protein (FAP) with a (4-Quinolinoyl)-glycyl-2-cyanopyrrolidine Scaffold. ACS Med Chem Lett. 2013 Mar 18;4(5):491-6. | ||||
| REF 45 | US patent application no. 9346814B2, FAP inhibitors | ||||
| REF 46 | Approaches towards the development of chimeric DPP4/ACE inhibitors for treating metabolic syndrome. Bioorg Med Chem Lett. 2017 Jun 1;27(11):2313-2318. | ||||
| REF 47 | Acylated Gly-(2-cyano)pyrrolidines as inhibitors of fibroblast activation protein (FAP) and the issue of FAP/prolyl oligopeptidase (PREP)-selectivity. Bioorg Med Chem Lett. 2012 May 15;22(10):3412-7. | ||||
| REF 48 | P2-substituted N-acylprolylpyrrolidine inhibitors of prolyl oligopeptidase: biochemical evaluation, binding mode determination, and assessment in a cellular model of synucleinopathy. J Med Chem. 2012 Nov 26;55(22):9856-67. | ||||
| REF 49 | Discovery of potent, selective, and orally bioavailable pyridone-based dipeptidyl peptidase-4 inhibitors. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1346-9. | ||||
| REF 50 | Discovery of Novel Tricyclic Heterocycles as Potent and Selective DPP-4 Inhibitors for the Treatment of Type 2 Diabetes. ACS Med Chem Lett. 2016 Mar 12;7(5):498-501. | ||||
| REF 51 | Novel isoindoline compounds for potent and selective inhibition of prolyl dipeptidase DPP8. Bioorg Med Chem Lett. 2005 Feb 1;15(3):687-91. | ||||
| REF 52 | (2S,4S)-1-[2-(1,1-dimethyl-3-oxo-3-pyrrolidin-1-yl-propylamino)acetyl]-4-fluoro-pyrrolidine-2-carbonitrile: a potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3596-600. | ||||
| REF 53 | Rational design of a novel, potent, and orally bioavailable cyclohexylamine DPP-4 inhibitor by application of molecular modeling and X-ray crystallography of sitagliptin. Bioorg Med Chem Lett. 2007 Jun 15;17(12):3384-7. | ||||
| REF 54 | Medicinal chemistry approaches to the inhibition of dipeptidyl peptidase-4 for the treatment of type 2 diabetes. Bioorg Med Chem. 2009 Mar 1;17(5):1783-802. | ||||
| REF 55 | Synthesis and evaluation of structurally constrained imidazolidin derivatives as potent dipeptidyl peptidase IV inhibitors. Eur J Med Chem. 2009 Aug;44(8):3318-22. | ||||
| REF 56 | Crystal structure of Porphyromonas gingivalis dipeptidyl peptidase 4 and structure-activity relationships based on inhibitor profiling. Eur J Med Chem. 2017 Oct 20;139:482-491. | ||||
| REF 57 | Development of potent and selective dipeptidyl peptidase II inhibitors. Bioorg Med Chem Lett. 2002 Oct 21;12(20):2825-8. | ||||
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