Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T52189 | Target Info | |||
| Target Name | ATP-citrate synthase (ACLY) | ||||
| Synonyms |
Citrate cleavage enzyme; ATP-citrate (pro-S-)-lyase; ACL
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| Target Type | Successful Target | ||||
| Gene Name | ACLY | ||||
| Biochemical Class | Acyltransferase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 3 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(S)-2-[(R)-7-(5-Chloro-3-nitro-indol-1-yl)-2-hydroxy-heptyl]-2-hydroxy-succinic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL120641; BDBM50066679
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| Activity |
Ki = 64000 nM
|
[1] | |||
| Compound Name |
2-[6-(3,5-Dichloro-pyridin-4-yl)-hexylsulfanylmethyl]-2-hydroxy-succinic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL331902; BDBM50053013
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| Activity |
Ki = 121000 nM
|
[2] | |||
| Compound Name |
(S)-2-[(R)-6-(5-Chloro-indol-1-yl)-2-hydroxy-hexyl]-2-hydroxy-succinic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL120253; BDBM50066704
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| Activity |
Ki = 160000 nM
|
[1] | |||
| Non Binders of This Target (in total, 2 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-Hydroxy-2-(3-naphthalen-2-yl-propylsulfanylmethyl)-succinic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL118897; BDBM50052984
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| Activity |
Ki = 300000 nM
|
[2] | |||
| Compound Name |
2-Hydroxy-2-(6-phenyl-hexylsulfanylmethyl)-succinic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL120621; BDBM50052992
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| Activity |
Ki = 320000 nM
|
[2] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | ATP-Citrate lyase as a target for hypolipidemic intervention. 2. Synthesis and evaluation of (3R,5S)-omega-substituted-3-carboxy-3, 5-dihydroxyalkanoic acids and their gamma-lactone prodrugs as inhibitors of the enzyme in vitro and in vivo. J Med Chem. 1998 Sep 10;41(19):3582-95. | ||||
| REF 2 | ATP-citrate lyase as a target for hypolipidemic intervention. Design and synthesis of 2-substituted butanedioic acids as novel, potent inhibitors of the enzyme. J Med Chem. 1996 Aug 30;39(18):3569-84. | ||||
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