Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T54156 | Target Info | |||
| Target Name | Matrix metalloproteinase-9 (MMP-9) | ||||
| Synonyms |
Matrix metalloproteinase 9; GELB; CLG4B; 92 kDa type IV collagenase; 92 kDa gelatinase
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|
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| Target Type | Clinical trial Target | ||||
| Gene Name | MMP9 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 256 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Zoledronate
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|
Approved | Compound Info | ||
| Synonyms |
Aclasta; Reclast; ZOL; Zometa; Novartis brand of zoledronic acid; Zoledronic acid; Zometa Concentrate; Bisphosphonate 3; CGP 42446; CGP 42446A; Aclasta (TN); CGP 42'446; CGP-42446; KS-1132; Reclast (TN); Zoledronic acid (INN); Zoledronic acid [USAN:INN]; Zomera (TN); Zometa (Novartis); Zometa (TN); CGP-42'446; Zometa, Zomera, Aclasta and Reclast, Zoledronic Acid; [1-hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl]bis(phosphonic acid); (1-Hydroxy-2-imidazol-1-ylethylidene)diphosphonic acid; (1-hydroxy-2-(1H-imidazol-1-yl)ethylidene)bisphosphonic acid; (1-hydroxy-2-imidazol-1-yl-1-phosphonoethyl)phosphonic acid; (1-hydroxy-2-imidazol-1-yl-phosphonoethyl)phosphonic acid monohydrate; 2-(imidazol-1-yl)-1-hydroxyethane-1,1-diphosphonic acid; 2-(imidazol-1-yl)-1-hydroxyethylidene-1,1-bisphosphonic acid
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| Activity |
IC50 = 52000 nM
|
[1] | |||
| Compound Name |
Tiludronic acid
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Approved | Compound Info | ||
| Synonyms |
Skelid; Tiludronate disodium; ME-3737; SR-41319
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
1607004-34-1
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|
Patented | Compound Info | ||
| Synonyms |
ADAMTS Inhibitor C7; SCHEMBL15692551; CHEMBL3980860; BDBM194644; 1607004-34-1; US9206139, 3
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
US9206139, 4
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|
Patented | Compound Info | ||
| Synonyms |
CHEMBL3955404; SCHEMBL15692527; BDBM194645; US9206139, 4
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|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
2-(benzyloxyamino)-N-hydroxyhexanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL228230; 2-(benzyloxyamino)-N-hydroxyhexanamide
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| Activity |
IC50 = 81000 nM
|
[3] | |||
| Compound Name |
N,N'-Bis(4-Amino-2-Methylquinolin-6-Yl)Urea
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|
Investigative | Compound Info | ||
| Synonyms |
Aminoquinuride; Surfen; aminokinuride; UNII-08T7936572; 3811-56-1; N,N'-BIS(4-AMINO-2-METHYLQUINOLIN-6-YL)UREA; 1,3-bis(4-amino-2-methylquinolin-6-yl)urea; N,N'-Bis(4-amino-2-methyl-6-quinolinyl)urea; Aminochinurid; 08T7936572; Aminochinuridum; Aminoquinuridum; Aminoquinurida; Aminokinuridum; Aminochincarbamidum; Aminoquin carbamide; NSC12155; Aminoquinuride [INN]; NCGC00013130-04; NCGC00013130-03; 5424-37-3; Aminoquinuridum [INN-Latin]; Aminoquinurida [INN-Spanish]; 1pwp; N,N-Bis(4-aminochinaldyl-6)harnstoff
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| Activity |
IC50 = 100000 nM
|
[4] | |||
| Compound Name |
N1,N3-bis(3-methoxybenzyl)isophthalamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL605201; N1,N3-bis(3-methoxybenzyl)isophthalamide; SCHEMBL5332068
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| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
(biphenyl-3-ylamino)methylenediphosphonic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL55371; AC1NQQUY; (biphenyl-3-ylamino)methylenediphosphonic acid; BPH-218; NSC725581; BDBM50138040; ZINC13532369; NSC-725581; [(3-phenylanilino)-phosphonomethyl]phosphonic acid; [(3-phenylanilino)-phosphono-methyl]phosphonic acid; [(Biphenyl-3-ylamino)-phosphono-methyl]-phosphonic acid; (Biphenyl-3-yl)- aminomethylene-1,1-bisphosphonate (dihydrate); Phosphonic acid, [([1,1'-biphenyl]-3-ylamino)methylene]bis-
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-(4-chlorobenzyloxyamino)-N-hydroxyhexanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL388309; 2-(4-chlorobenzyloxyamino)-N-hydroxyhexanamide
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| Activity |
IC50 = 125000 nM
|
[6] | |||
| Compound Name |
2-(4-chlorobenzyloxyamino)-N-hydroxypropanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL228229; 2-(4-chlorobenzyloxyamino)-N-hydroxypropanamide
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| Activity |
IC50 = 141000 nM
|
[6] | |||
| Compound Name |
(2R)-N-Hydroxy-2-[(biphenyl-4-ylcarbonyl)amino]-3-phenylpropanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL157592; BDBM50063149; Biphenyl-4-carboxylic acid ((R)-1-hydroxycarbamoyl-2-phenyl-ethyl)-amide
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| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
N-(4-Amino-2-methylquinolin-6-yl)-3-quinolin-5-ylbenzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3098998; BDBM50444720
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|
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| Activity |
IC50 = 50000 nM
|
[4] | |||
| Compound Name |
(3R)-6-Cyclohexyl-3-[3-(2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl)-1,2,4-oxadiazol-5-yl]-N-hydroxyhexanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL226852; SCHEMBL6599390; BDBM50216790
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|
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| Activity |
IC50 = 50000 nM
|
[8] | |||
| Compound Name |
3-Fluorobenzyl 6-oxo-1,6-dihydropyridine-2-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL398892; BDBM50227585
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| Activity |
IC50 = 50000 nM
|
[9] | |||
| Compound Name |
(R)-2-(4-Fluoro-3,5-dimethylphenylamino)-6-(4-fluorobenzylamino)-N-hydroxyhexanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1269994; SCHEMBL4738506; BDBM50329265; (2R)-2-(4-fluoro-3,5-dimethylanilino)-6-[(4-fluorophenyl)methylamino]-N-hydroxyhexanamide
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| Activity |
Ki ~ 50000 nM
|
[10] | |||
| Compound Name |
(S)-2-(4-Fluoro-3,5-dimethylbenzyl)-6-(4-fluorobenzylamino)-N-hydroxyhexanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1760324; SCHEMBL3436885; BDBM50340754; (2S)-2-[(4-fluoro-3,5-dimethylphenyl)methyl]-6-[(4-fluorophenyl)methylamino]-N-hydroxyhexanamide
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| Activity |
Ki ~ 50000 nM
|
[10] | |||
| Compound Name |
5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3589199; BDBM50270510
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|
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| Activity |
IC50 = 50000 nM
|
[11] | |||
| Compound Name |
(2R)-2-(4-Fluoro-3,5-dimethylphenoxy)-6-[1-(4-fluorophenyl)propylamino]-N-hydroxyhexanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2012837; BDBM50379534
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|
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| Activity |
Ki ~ 50000 nM
|
[10] | |||
| Compound Name |
(2S)-2-[(4-Fluoro-3,5-dimethylphenyl)methyl]-6-[1-(4-fluorophenyl)propylamino]-N-hydroxyhexanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2010824; BDBM50379535
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| Activity |
Ki ~ 50000 nM
|
[10] | |||
| Compound Name |
N-Hydroxy-N-[2-[4-(2-methyl-quinolin-4-ylmethoxy)-benzenesulfonyl]-1-(4-oxo-cyclohexylidenemethyl)-ethyl]-formamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL98852; SCHEMBL3996441; BDBM50146468
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|
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| Activity |
IC50 = 50000 nM
|
[12] | |||
| Compound Name |
Chembl4278980
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50466704
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|
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| Activity |
IC50 ~ 50000 nM
|
[13] | |||
| Compound Name |
(4R)-N-Hydroxy-3-naphthalen-2-ylsulfonyl-1,3-thiazolidine-4-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1957599; BDBM50366201
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|
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| Activity |
IC50 ~ 50000 nM
|
[14] | |||
| Compound Name |
1,5-Dimethyl-5-(4-phenoxyphenyl)hexahydropyrimidine-2,4,6-trione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL366956; SCHEMBL6810545; BDBM50099124; 1,5-Dimethyl-5-(4-phenoxy-phenyl)-pyrimidine-2,4,6-trione; 1,5-dimethyl-5-(4-phenoxyphenyl)-1,3-diazinane-2,4,6-trione
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|
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| Activity |
IC50 ~ 50000 nM
|
[15] | |||
| Compound Name |
(2R)-2-[(Biphenyl-4-ylcarbonyl)amino]-3-phenylpropanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL49671; BDBM50063131; (R)-2-[(Biphenyl-4-carbonyl)-amino]-3-phenyl-propionic acid
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| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
Chembl4212208
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL8229791; BDBM50455848
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| Activity |
IC50 = 50000 nM
|
[16] | |||
| Compound Name |
6-Mercapto-pyridine-2-carboxylic acid biphenyl-3-ylmethyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL251426; BDBM50227601
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|
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| Activity |
IC50 = 50000 nM
|
[9] | |||
| Compound Name |
(2R)-2-(4-Fluoro-3,5-dimethylanilino)-6-[1-(4-fluorophenyl)propylamino]-N-hydroxyhexanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2012836; BDBM50379536
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|
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| Activity |
Ki ~ 50000 nM
|
[10] | |||
| Compound Name |
(2S)-2-[[5-(Dimethylamino)naphthalen-1-yl]sulfonylamino]-N-[(2S)-1-oxo-1-[(2-sulfanylidene-3H-1,3,4-thiadiazol-5-yl)amino]propan-2-yl]-3-phenylpropanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3142608
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|
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| Activity |
Ki = 50000 nM
|
[17] | |||
| Compound Name |
(R)-2-(4-Fluoro-3,5-dimethylphenoxy)-6-(4-fluorobenzylamino)-N-hydroxyhexanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1760322; BDBM50340768
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|
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| Activity |
Ki ~ 50000 nM
|
[10] | |||
| Compound Name |
(4S)-5-Amino-4-[[(2S)-3-(1H-imidazol-5-yl)-2-[3-[4-(4-phenylphenyl)phenyl]propanoylamino]propanoyl]amino]-5-oxopentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL6869254; CHEMBL3675578; BDBM120228; US8691753, 77
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| Activity |
Ki ~ 50000 nM
|
[18] | |||
| Compound Name |
N-Hydroxy-2-[4-(4-methanesulfinyl-phenoxy)-benzenesulfonyl]-benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL576762; BDBM50299066
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| Activity |
IC50 = 51000 nM
|
[19] | |||
| Compound Name |
N-Hydroxy-2-[4-(3,5-dibromobenzyloxy)phenylsulfonylamino]acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431021; BDBM50441215
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| Activity |
IC50 = 51000 nM
|
[20] | |||
| Compound Name |
Chembl4215930
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Investigative | Compound Info | ||
| Synonyms |
BDBM50456795
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| Activity |
IC50 = 51600 nM
|
[21] | |||
| Compound Name |
Chembl4218730
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Investigative | Compound Info | ||
| Synonyms |
BDBM50456797
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| Activity |
IC50 = 51900 nM
|
[21] | |||
| Compound Name |
[4-[4-(Thiiran-2-ylmethylsulfonyl)phenoxy]phenyl] N-propylcarbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2442879; BDBM50442358
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| Activity |
Ki = 52000 nM
|
[22] | |||
| Compound Name |
N-Hydroxy-N-[2-[4-(2-methyl-quinolin-4-ylmethoxy)-benzenesulfonyl]-1-(tetrahydro-pyran-4-ylidenemethyl)-ethyl]-formamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL99045; SCHEMBL3881836; BDBM50146477
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| Activity |
IC50 = 53000 nM
|
[12] | |||
| Compound Name |
(2S)-2-(Naphthalen-2-ylsulfonylamino)-N-[(2S)-1-oxo-1-[(2-sulfanylidene-3H-1,3,4-thiadiazol-5-yl)amino]propan-2-yl]-3-phenylpropanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3142591
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| Activity |
Ki = 53000 nM
|
[17] | |||
| Compound Name |
N-Hydroxy-N-[2-[4-(2-methyl-quinolin-4-ylmethoxy)-benzenesulfonyl]-1-(4-oxo-cyclohexylmethyl)-ethyl]-formamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL99365; SCHEMBL3883225; BDBM50146467
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| Activity |
IC50 = 53000 nM
|
[12] | |||
| Compound Name |
Procyanidin C1
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Investigative | Compound Info | ||
| Synonyms |
Procyanidol C1; Proanthocyanidin C1; Cinnamtannin A1; Procyanidin C-1; UNII-33516LCW4F; Procyanidin trimer C1; CHEMBL290632; 33516LCW4F; [Epicatechin(4b->8)]2-epicatechin; [Epicatechin-(4beta->8)]2-epicatechin; EC-(4b,8)-EC-(4b,8)-EC; Epicatechin-(4beta->8)-epicatechin-(4beta->8)-epicatechin; Proanthocyanidin C1;; SCHEMBL678609; CTK4H7642; DTXSID10190562; HY-N2342; BDBM50240460; ZINC96095372; ACN-053267; CS-0021304; C17624; Q7247556; epicatechin-(4beta-8)-epicatechin-(4beta-8)-epicatechin; Epicatechin-(4.beta.-->8)epicatechin-(4.beta.-->8)epicatechin
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| Activity |
IC50 = 53200 nM
|
[23] | |||
| Compound Name |
Chembl4206886
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Investigative | Compound Info | ||
| Synonyms |
BDBM50456777
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| Activity |
IC50 = 53600 nM
|
[21] | |||
| Compound Name |
Chembl4210975
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Investigative | Compound Info | ||
| Synonyms |
BDBM50456781
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| Activity |
IC50 = 54600 nM
|
[21] | |||
| Compound Name |
[[4-(4-Chlorophenoxy)anilino]-phosphonomethyl]phosphonic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440431; BDBM50442509
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| Activity |
IC50 = 55000 nM
|
[1] | |||
| Compound Name |
Chembl4211708
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Investigative | Compound Info | ||
| Synonyms |
BDBM50456798
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| Activity |
IC50 = 56200 nM
|
[21] | |||
| Compound Name |
Chembl4203717
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Investigative | Compound Info | ||
| Synonyms |
BDBM50456771
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| Activity |
IC50 = 57800 nM
|
[21] | |||
| Compound Name |
N-(4'-Cyano-1,1'-biphenyl-4-ylsulfonyl)valine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL45040; 2-(4''-Cyano-biphenyl-4-sulfonylamino)-3-methyl-butyric acid; SCHEMBL7403535; BDBM50084287; (S)-2-(4''-cyano-biphenyl-4-sulfonylamino)-3-methyl-butyric acid; (2S)-2-[[4-(4-cyanophenyl)phenyl]sulfonylamino]-3-methylbutanoic acid
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| Activity |
IC50 = 58884.37 nM
|
[24] | |||
| Compound Name |
2-Bromobenzyl 6-oxo-1,6-dihydropyridine-2-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL254239; BDBM50227569
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| Activity |
IC50 = 59000 nM
|
[9] | |||
| Compound Name |
2,6-Difluorobenzyl 6-oxo-1,6-dihydropyridine-2-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL253375; BDBM50227604
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| Activity |
IC50 = 60000 nM
|
[9] | |||
| Compound Name |
N-Hydroxy-4-methylbenzenesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
Benzenesulfonamide, N-hydroxy-4-methyl-; N-hydroxy-4-methylbenzene-1-sulfonamide; tosylhydroxylamine; N-Tosylhydroxylamine; N-hydroxy-4-methyl-benzenesulfonamide; Hydroxysulfonamide 58; ACMC-209djs; p-tolyl-N-hydroxysulfonamide; N-hydroxy-4-toluenesulfonamide; CHEMBL121559; SCHEMBL1832454; BDBM11377; CTK8B0907; DTXSID10435263; ANW-21830; MFCD11850835; ZINC13813791; AKOS015888649; MCULE-3823003338; SC-50302; DB-064280; CS-0068832; FT-0760726; V3581; A-3307
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| Activity |
Ki = 60000 nM
|
[25] | |||
| Compound Name |
5-(Benzothiazol-2-ylazamethylene)-1-(4-sulfophenyl)-2-pyrazoline-3-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL438832; AKOS024277864; ST019413
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| Activity |
IC50 = 60100 nM
|
[26] | |||
| Compound Name |
(3R)-6-Cyclohexyl-N-hydroxy-3-(3-{[(phenylsulfonyl)amino]carbonyl}-1,2,4-oxadiazol-5-yl)hexanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL439012; SCHEMBL6178395; BDBM50216817
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| Activity |
IC50 = 61000 nM
|
[8] | |||
| Compound Name |
Cyclobutyl 6-oxo-1,6-dihydropyridine-2-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL251937; BDBM50227567
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|
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| Activity |
IC50 = 62000 nM
|
[9] | |||
| Compound Name |
N-(4'-Fluoro-1,1'-biphenyl-4-ylsulfonyl)valine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL418442; SCHEMBL7406959; BDBM50084301; 2-(4''-Fluoro-biphenyl-4-sulfonylamino)-3-methyl-butyric acid; (S)-2-(4''-fluoro-biphenyl-4-sulfonylamino)-3-methyl-butyric acid; (2S)-2-[[4-(4-fluorophenyl)phenyl]sulfonylamino]-3-methylbutanoic acid
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| Activity |
IC50 = 64000 nM
|
[27] | |||
| Compound Name |
((4S,5S)-2-Phenylethynyl-5-vinyl-4,5-dihydro-oxazol-4-yl)-methanol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL364783; BDBM50152644
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| Activity |
Ki = 65000 nM
|
[28] | |||
| Compound Name |
(2S)-2-[[4-(3-Fluorophenyl)phenyl]sulfonylamino]-3-methylbutanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL539683; SCHEMBL7404221; BDBM50084292; 2-(3''-Fluoro-biphenyl-4-sulfonylamino)-3-methyl-butyric acid
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| Activity |
IC50 = 65000 nM
|
[29] | |||
| Compound Name |
4-Bromo-N-hydroxybenzenesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
p-Bromo-N-hydroxybenzenesulfonamide; Benzenesulfonamide, p-bromo-N-hydroxy-; 4-bromo-N-hydroxybenzene-1-sulfonamide; N-(p-bromobenzenesulfonyl)hydroxylamine; BRN 2645335; Hydroxysulfonamide 56; p-Bromobenzenesulfonhydroxamide; CHEMBL123404; SCHEMBL8229526; BDBM11375; CTK8H4740; DTXSID90941675; N-Hydroxy-p-bromobenzenesulfonamide; ZINC6093148; 4-Bromo-N-hydroxybenzenesulfonamide #
Click to Show/Hide
|
||||
| Activity |
Ki = 66000 nM
|
[25] | |||
| Compound Name |
Pentyl 6-oxo-1,6-dihydropyridine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL252326; BDBM50227593
Click to Show/Hide
|
||||
| Activity |
IC50 = 66000 nM
|
[9] | |||
| Compound Name |
Chembl4212449
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50456788
Click to Show/Hide
|
||||
| Activity |
IC50 = 66600 nM
|
[21] | |||
| Compound Name |
3-Chlorobenzyl 6-oxo-1,6-dihydropyridine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL253823; BDBM50227589
Click to Show/Hide
|
||||
| Activity |
IC50 = 67000 nM
|
[9] | |||
| Compound Name |
2,4,5-Trifluorobenzyl 6-oxo-1,6-dihydropyridine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL398450; BDBM50227548
Click to Show/Hide
|
||||
| Activity |
IC50 = 67000 nM
|
[9] | |||
| Compound Name |
Thiophen-3-yl 6-oxo-1,6-dihydropyridine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL398838; BDBM50227596
Click to Show/Hide
|
||||
| Activity |
IC50 = 67000 nM
|
[9] | |||
| Compound Name |
Isopropyl 6-oxo-1,6-dihydropyridine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL445939; BDBM50227603
Click to Show/Hide
|
||||
| Activity |
IC50 = 67000 nM
|
[9] | |||
| Compound Name |
3-Bromobenzyl 6-oxo-1,6-dihydropyridine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL254240; BDBM50227564
Click to Show/Hide
|
||||
| Activity |
IC50 = 67000 nM
|
[9] | |||
| Compound Name |
((4S,5S)-2-p-Tolyl-5-vinyl-4,5-dihydro-oxazol-4-yl)-methanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL184058; BDBM50152657
Click to Show/Hide
|
||||
| Activity |
Ki = 68000 nM
|
[28] | |||
| Compound Name |
But-2-ynyl 6-oxo-1,6-dihydropyridine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL254837; BDBM50227600
Click to Show/Hide
|
||||
| Activity |
IC50 = 68000 nM
|
[9] | |||
| Compound Name |
4-Chlorobenzyl 6-oxo-1,6-dihydropyridine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL254238; BDBM50227571
Click to Show/Hide
|
||||
| Activity |
IC50 = 68000 nM
|
[9] | |||
| Compound Name |
6-Oxo-1,6-dihydro-pyridine-2-carboxylic acid 4-methyl-benzyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL253801; BDBM50227586
Click to Show/Hide
|
||||
| Activity |
IC50 = 68000 nM
|
[9] | |||
| Compound Name |
3-Methylbut-2-enyl 6-oxo-1,6-dihydropyridine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL254627; BDBM50227565
Click to Show/Hide
|
||||
| Activity |
IC50 = 69000 nM
|
[9] | |||
| Compound Name |
(Hydroxyamino)(4-iodophenyl)sulfone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Hydroxysulfonamide 57; CHEMBL120934; SCHEMBL8229583; BDBM11376; ZINC5570003; AKOS024355469; N-hydroxy-4-iodobenzene-1-sulfonamide; MCULE-2099459518; ST50982751
Click to Show/Hide
|
||||
| Activity |
Ki = 69000 nM
|
[25] | |||
| Compound Name |
Benzyl 6-oxo-1,6-dihydropyridine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL399070; SCHEMBL20083642; BDBM50227551; benzyl 6-oxo-1H-pyridine-2-carboxylate
Click to Show/Hide
|
||||
| Activity |
IC50 = 69000 nM
|
[9] | |||
| Compound Name |
Perfluorobenzyl 6-oxo-1,6-dihydropyridine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL253820; BDBM50227562
Click to Show/Hide
|
||||
| Activity |
IC50 = 69000 nM
|
[9] | |||
| Compound Name |
Thiophen-2-yl 6-oxo-1,6-dihydropyridine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL254039; BDBM50227537
Click to Show/Hide
|
||||
| Activity |
IC50 = 70000 nM
|
[9] | |||
| Compound Name |
3,5-Difluorobenzyl 6-oxo-1,6-dihydropyridine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL399684; BDBM50227534
Click to Show/Hide
|
||||
| Activity |
IC50 = 71000 nM
|
[9] | |||
| Compound Name |
Chembl4211189
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50456774
Click to Show/Hide
|
||||
| Activity |
IC50 = 72600 nM
|
[21] | |||
| Compound Name |
N-(p-Fluorobenzenesulfonyl)hydroxylamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
4-fluoro-N-hydroxybenzene-1-sulfonamide; Hydroxysulfonamide 54; CHEMBL332145; SCHEMBL2492594; BDBM11373; 4-fluoro-n-hydroxybenzenesulfonamide; N-Hydroxy-4-fluorobenzenesulfonamide
Click to Show/Hide
|
||||
| Activity |
Ki = 73000 nM
|
[25] | |||
| Compound Name |
Cinnamyl 6-oxo-1,6-dihydropyridine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL254657; BDBM50227587
Click to Show/Hide
|
||||
| Activity |
IC50 = 73000 nM
|
[9] | |||
| Compound Name |
3-Phenoxybenzyl 6-mercaptopicolinate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL250069; BDBM50227575
Click to Show/Hide
|
||||
| Activity |
IC50 = 75000 nM
|
[9] | |||
| Compound Name |
(2S)-N-Hydroxy-1-(4-phenylphenyl)sulfonylpyrrolidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1957597; BDBM50366199
Click to Show/Hide
|
||||
| Activity |
IC50 = 76000 nM
|
[14] | |||
| Compound Name |
4-Chloro-N-hydroxybenzene-1-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
N-(p-chlorobenzenesulfonyl)hydroxylamine; 4-chloro-N-hydroxybenzenesulfonamide; NSC528513; Hydroxysulfonamide 55; CHEMBL301469; SCHEMBL5194625; BDBM11374; DTXSID10326460; ZINC1607221; 4-Chloro-N-hydroxy-benzenesulfonamide; NSC-528513; DS-014970
Click to Show/Hide
|
||||
| Activity |
Ki = 76000 nM
|
[25] | |||
| Compound Name |
2-Fluorobenzyl 6-oxo-1,6-dihydropyridine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL253373; BDBM50227552
Click to Show/Hide
|
||||
| Activity |
IC50 = 76000 nM
|
[9] | |||
| Compound Name |
N-Hydroxybenzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Benzenesulfohydroxamic acid; Piloty's acid; Benzenesulfonamide, N-hydroxy-; Benzenesulphonohydroxamic acid; Benzsulfohydroxamic acid; Hydroxamic acid, benzsulfo-; N-(Phenylsulfonyl)hydroxylamine; Hydroxylamine, N-(phenylsulfonyl)-; UNII-C64L4UMH19; CHEMBL55310; C64L4UMH19; MFCD00025013; EINECS 209-973-8; N-Hydroxy-benzenesulfonamide; BRN 2257368; Benzenesulfohyd; piloty acid; BENZENESULFOHYDROXAMICACID; Hydroxysulfonamide 53; Hydroxyphenylsulfonamide; Benzenesulfhydroxamic acid; (hydroxyamino)phenylsulfone; C6H7NSO3; Benzenesulfonamide,N-hydroxy-; 4-11-00-00093 (Beilstein Handbook Reference); SCHEMBL184252; DTXSID4060521; BDBM11372; CTK5B0780; HMS3650A13; NSC45357; ZINC4284435; 1634AH; 7672AF; ANW-43953; NSC-45357; AKOS001139035; MCULE-1579584179; NE34189; VZ36592; AS-59127; ST50825041; SR-01000946758; SR-01000946758-1; Q27275238
Click to Show/Hide
|
||||
| Activity |
Ki = 78000 nM
|
[25] | |||
| Compound Name |
Phenethyl 6-oxo-1,6-dihydropyridine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL255051; BDBM50227541
Click to Show/Hide
|
||||
| Activity |
IC50 = 81000 nM
|
[9] | |||
| Compound Name |
2-Chlorobenzyl 6-oxo-1,6-dihydropyridine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL399685; BDBM50227554
Click to Show/Hide
|
||||
| Activity |
IC50 = 81000 nM
|
[9] | |||
| Compound Name |
Thioacetic acid S-((4S,5S)-2-biphenyl-4-yl-5-vinyl-4,5-dihydro-oxazol-4-yl) ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL363953; BDBM50152633
Click to Show/Hide
|
||||
| Activity |
Ki = 81000 nM
|
[28] | |||
| Compound Name |
Chembl4202989
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50456792
Click to Show/Hide
|
||||
| Activity |
IC50 = 82600 nM
|
[21] | |||
| Compound Name |
Benzenemethanesulfonamide, N-hydroxy-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Hydroxysulfonamide 52; N-Benzylsulfonylhydroxylamin; CHEMBL333122; N-hydroxyphenylmethanesulfonamide; SCHEMBL10656290; BDBM11371; N-hydroxy-1-phenylmethanesulfonamide
Click to Show/Hide
|
||||
| Activity |
Ki = 83000 nM
|
[25] | |||
| Compound Name |
4-Phenoxybutyl 6-mercaptopicolinate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL254610; BDBM50227602
Click to Show/Hide
|
||||
| Activity |
IC50 = 83000 nM
|
[9] | |||
| Compound Name |
Chembl4211258
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50456773
Click to Show/Hide
|
||||
| Activity |
IC50 = 83400 nM
|
[21] | |||
| Compound Name |
alpha-Arylsulfonylamino hydroxamate 3S
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL43644; BDBM12077; (2S)-2-{[4-(4-bromophenyl)benzene]sulfonamido}-N-hydroxy-3-methylbutanamide; (S)-N-Hydroxy-3-methyl-2-[[(4'-bromo-1,1'-biphenyl-4-yl)sulfonyl]amino]butanamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 84000 nM
|
[29] | |||
| Compound Name |
2,5-Difluorobenzyl 6-oxo-1,6-dihydropyridine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL399304; BDBM50227547
Click to Show/Hide
|
||||
| Activity |
IC50 = 85000 nM
|
[9] | |||
| Compound Name |
[[4-(4-Bromophenoxy)anilino]-phosphonomethyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440432; BDBM50442508
Click to Show/Hide
|
||||
| Activity |
IC50 = 87000 nM
|
[1] | |||
| Compound Name |
Benzyl 6-mercaptopicolinate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL402720; BDBM50227533
Click to Show/Hide
|
||||
| Activity |
IC50 = 88000 nM
|
[9] | |||
| Compound Name |
Thioacetic acid S-[(4S,5S)-2-(4-bromo-phenyl)-5-vinyl-4,5-dihydro-oxazol-4-yl] ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL363675; BDBM50152647
Click to Show/Hide
|
||||
| Activity |
Ki = 88000 nM
|
[28] | |||
| Compound Name |
3-Methoxybenzyl 6-oxo-1,6-dihydropyridine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL252965; BDBM50227578
Click to Show/Hide
|
||||
| Activity |
IC50 = 88000 nM
|
[9] | |||
| Compound Name |
(2R,3R)-4-[(2R)-2-(3-Chlorophenyl)pyrrolidin-1-yl]-2,3-dihydroxy-4-oxo-N-[(1R)-1-(4-pyrazol-1-ylphenyl)ethyl]butanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1770629; SCHEMBL8224023; BDBM50342963
Click to Show/Hide
|
||||
| Activity |
Ki = 88400 nM
|
[30] | |||
| Compound Name |
Furan-2-yl 6-oxo-1,6-dihydropyridine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL254821; BDBM50227529
Click to Show/Hide
|
||||
| Activity |
IC50 = 90000 nM
|
[9] | |||
| Compound Name |
Thiophen-3-yl 6-mercaptopicolinate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL399999; BDBM50227561
Click to Show/Hide
|
||||
| Activity |
IC50 = 90000 nM
|
[9] | |||
| Compound Name |
N-(3-(1-Tert-butylpiperidin-4-yl)-1-(4-((2-methylquinolin-4-yl)methoxy)phenylsulfonyl)propan-2-yl)-N-hydroxyformamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL400206; BDBM50197217
Click to Show/Hide
|
||||
| Activity |
IC50 = 90000 nM
|
[31] | |||
| Compound Name |
N-Hydroxy-N-{1-(1-isobutyl-piperidin-4-ylmethyl)-2-[4-(2-methyl-quinolin-4-ylmethoxy)-benzenesulfonyl]-ethyl}-formamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL98390; BDBM50146478
Click to Show/Hide
|
||||
| Activity |
IC50 = 90000 nM
|
[12] | |||
| Compound Name |
Cyclohexyl 6-mercaptopicolinate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL442286; BDBM50227588
Click to Show/Hide
|
||||
| Activity |
IC50 = 91000 nM
|
[9] | |||
| Compound Name |
3-Methoxybenzyl 6-mercaptopicolinate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL254406; BDBM50227568
Click to Show/Hide
|
||||
| Activity |
IC50 = 93000 nM
|
[9] | |||
| Compound Name |
Chembl4211771
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50456785
Click to Show/Hide
|
||||
| Activity |
IC50 = 93100 nM
|
[21] | |||
| Compound Name |
4-Phenoxybutyl 6-oxo-1,6-dihydropyridine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL253372; BDBM50227559
Click to Show/Hide
|
||||
| Activity |
IC50 = 94000 nM
|
[9] | |||
| Compound Name |
(4S,5S)-2-Styryl-5-vinyl-4,5-dihydro-oxazole-4-thiol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL186559; BDBM50152635
Click to Show/Hide
|
||||
| Activity |
Ki = 94000 nM
|
[28] | |||
| Compound Name |
(4S,5S)-2-(4-Bromo-phenyl)-4-phenylsulfanyl-5-vinyl-4,5-dihydro-oxazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL187808; BDBM50152642
Click to Show/Hide
|
||||
| Activity |
Ki = 94000 nM
|
[28] | |||
| Compound Name |
Cyclohexyl 6-oxo-1,6-dihydropyridine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL254838; BDBM50227583
Click to Show/Hide
|
||||
| Activity |
IC50 = 94000 nM
|
[9] | |||
| Compound Name |
4-Methoxybenzyl 6-mercaptopicolinate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL399908; BDBM50227579
Click to Show/Hide
|
||||
| Activity |
IC50 = 95000 nM
|
[9] | |||
| Compound Name |
Chembl4206821
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50456784
Click to Show/Hide
|
||||
| Activity |
IC50 = 95900 nM
|
[21] | |||
| Compound Name |
(2S)-4-Fluoro-2-[(4-methoxyphenyl)sulfonyl-(pyridin-3-ylmethyl)amino]butanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3585764; SCHEMBL13570539; BDBM50093570; (S)-N-(4-Methoxyphenylsulfonyl)-N-(3-pyridylmethyl)-2-amino-4-fluorobutanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[32] | |||
| Compound Name |
2-[(4-Methoxyphenyl)methylthio]-6-methyl-1H-pyrimidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
ML032; MLS000109390; CHEMBL500351; 2-[(4-methoxyphenyl)methylsulfanyl]-6-methyl-1H-pyrimidin-4-one; SMR000105333; SR-01000474780; CDS1_004684; CBMicro_030348; 6-methyl-2-(p-anisylthio)-1H-pyrimidin-4-one; Oprea1_680293; DivK1c_005724; cid_716696; SCHEMBL16743643; BDBM40478; CTK8J7376; HMS2282I24; ZINC8670459; AKOS000530959; MCULE-9257305475; BIM-0030343.P001; ST50101336; EC-000.1648; SR-01000474780-1; SR-01000474780-3; Q27164593; 2-[(4-methoxyphenyl)methylthio]-6-methylpyrimidin-4-ol; 2-(4-Methoxy-benzylsulfanyl)-6-methyl-3H-pyrimidin-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[33] | |||
| Compound Name |
[Phosphono-[4-(trifluoromethyl)anilino]methyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440440; BDBM50442517
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(S)-N-(4-Methoxyphenylsulfonyl)-N-(3-pyridylmethyl)aminobutanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3585760; SCHEMBL13570529; BDBM50093566; (2S)-2-[(4-methoxyphenyl)sulfonyl-(pyridin-3-ylmethyl)amino]butanoic acid; (S)-N-(4-Methoxyphenylsulfonyl)-N-(3-pyridylmethyl)-aminobutanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[32] | |||
| Compound Name |
Chembl4208066
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50457773
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[34] | |||
| Compound Name |
N-(4-Amino-2-methylquinolin-6-yl)-3-[4-(dimethylamino)phenyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3098985; BDBM50444734
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
5-((5-Methoxy-3-oxo-1H-indazol-2(3H)-yl)methyl)-5-methylimidazolidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1078396; SCHEMBL7899982; BDBM50313818
Click to Show/Hide
|
||||
| Activity |
Ki = 100000 nM
|
[35] | |||
| Compound Name |
(Methylamino)carbonylphosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL97388; SCHEMBL12758377; BDBM50146809; AKOS006379972
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[36] | |||
| Compound Name |
Thioacetic acid S-((4S,5S)-2-p-tolyl-5-vinyl-4,5-dihydro-oxazol-4-yl) ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL360868; BDBM50152654
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[28] | |||
| Compound Name |
Cyclohexanamine;3-methylbutylcarbamoylphosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1160686
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[36] | |||
| Compound Name |
(P-Tolylamino)methylenediphosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440439; SCHEMBL11570312; BDBM50442518; ZINC96286211; p-tolylaminomethylenedi-phosphonic acid; (4-Methylphenyl)aminomethylenebisphosphonic acid; [(4-methylanilino)-phosphonomethyl]phosphonic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(2R)-4-Fluoro-2-[(4-methoxyphenyl)sulfonyl-(pyridin-3-ylmethyl)amino]butanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3585763; SCHEMBL13570653; BDBM50093569; (R)-N-(4-Methoxyphenylsulfonyl)-N-(3-pyridylmethyl)-2-amino-4-fluorobutanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[32] | |||
| Compound Name |
(E)-N-(4-Amino-2-methylquinolin-6-yl)-3-(2-methoxyphenyl)prop-2-enamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3099009; BDBM50444709
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
[(3-Fluoroanilino)-phosphonomethyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440436; BDBM50442513
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(2R)-4-Fluoro-2-[(4-methoxyphenyl)sulfonyl-(pyridin-3-ylmethyl)amino]pent-4-enoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3585771; SCHEMBL13570943; BDBM50093577
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[32] | |||
| Compound Name |
[(4-Phenylanilino)-phosphono-methyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL293479; BDBM50138035; NSC725580; ZINC13673810; NSC-725580; (biphenyl-4-ylamino)methylenediphosphonic acid; (biphenyl-4-yl)-aminomethylene-1,1-bisphosphonate; (Biphenyl-4-yl)- aminomethylene-1,1-bisphosphonate; [(Biphenyl-4-ylamino)-phosphono-methyl]-phosphonic acid; Phosphonic acid, [([1,1'-biphenyl]-4-ylamino)methylene]bis-
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4215193
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50456799
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
[(2,4-Dichloroanilino)-phosphono-methyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL191613; BDBM50165966; 2,4-Dichloroanilinomethylenebisphosphonic acid; 2,4-DICHLOROPHENYLAMINOMETHYLENEBISPHOSPHONIC ACID; [(2,4-dichloro-phenyl)aminomethylene]-1,1-bisphosphonate; [(2,4-Dichloro-phenylamino)-phosphono-methyl]-phosphonic acid; Phosphonic acid, [[(2,4-dichlorophenyl)amino]methylene]bis-
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-Methoxybenzyl 6-oxo-1,6-dihydropyridine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL253172; BDBM50227538
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[9] | |||
| Compound Name |
4-(4-Methylphenoxy)-N-(4-pyridinylmethyl)benzenecarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
MLS000755676; SMR000337350; 4-(4-methylphenoxy)-N-[(pyridin-4-yl)methyl]benzamide; 4-(4-methylphenoxy)-N-(pyridin-4-ylmethyl)benzamide; CHEMBL1427458; BDBM46421; cid_4358655; HMS2618P15; KS-00003O5G; ZINC4054502; AKOS005107358; MCULE-5269053313; MS-1279; 4-(4-methylphenoxy)-N-(4-pyridylmethyl)benzamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
[(1S)-6-Fluoro-1-[[4-(4-methoxyphenyl)phenyl]sulfonylamino]hexyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3752419; BDBM50500716
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[38] | |||
| Compound Name |
(5S)-4-[2-(1-Adamantyl)ethyl]-5-butyl-1-[(2S)-1-(4-hydroxyphenyl)-3-[(2S)-2-[[(6R)-6-(naphthalen-2-ylmethyl)-2,3-dioxopiperazin-1-yl]methyl]pyrrolidin-1-yl]propan-2-yl]piperazine-2,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3593549; BDBM50104623
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[39] | |||
| Compound Name |
CID 50943150
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1933882; BDBM50360393; (E)-2-(1H-benzimidazol-2-yl)-3-(5-thiophen-2-ylthiophen-2-yl)prop-2-enenitrile
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
[(4-Cyanoanilino)-phosphonomethyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440437; BDBM50442516
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-[4-[2-[(3S)-3-Hydroxy-1-azabicyclo[2.2.2]octan-3-yl]ethynyl]phenoxy]-N-methylbenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1940296; BDBM50419619
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[41] | |||
| Compound Name |
(4S,5S)-2-(4-Chloro-phenyl)-5-vinyl-4,5-dihydro-oxazole-4-thiol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL361034; BDBM50152648
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[28] | |||
| Compound Name |
(S)-N-(4-Methoxyphenylsulfonyl)-N-(3-pyridylmethyl)-aminopent-4-enoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3585768; SCHEMBL13570710; BDBM50093574; (2S)-2-[(4-methoxyphenyl)sulfonyl-(pyridin-3-ylmethyl)amino]pent-4-enoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[32] | |||
| Compound Name |
(Diethylamino)carbonylphosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL97057; diethylcarbamoylphosphonic acid; Phosphonic acid, [(diethylamino)carbonyl]- (9CI); N-diethyl carbamyl phosphonate; SCHEMBL11592091; BDBM50146813
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[36] | |||
| Compound Name |
Sodium hydrogen (butylamino)carbonylphosphonate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL97389
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[36] | |||
| Compound Name |
(E)-N-Hydroxy-3-[4-(trifluoromethyl)phenyl]acrylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3394285; SCHEMBL12425758; BDBM50140176; (E)-3-[4-(trifluoromethyl)phenyl]prop-2-enehydroxamic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[42] | |||
| Compound Name |
Chembl4214716
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50456783
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
N-(4-Amino-2-methylquinolin-6-yl)-2-(4-phenylmethoxyphenoxy)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3098987; BDBM50444732
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
N-(4-Amino-2-methylquinolin-6-yl)-4-phenylbenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3099029; BDBM50444737
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
Schembl21751149
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3235912; BDBM50104619
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[39] | |||
| Compound Name |
Cyclooctylcarbamoylphosphonic Acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL97709; (cyclooctylamino)carbonylphosphonic acid; BDBM50146798
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[36] | |||
| Compound Name |
[(4-Phenoxyanilino)-phosphonomethyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440430; BDBM50442510
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(Dibutylamino)carbonylphosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL96438; BDBM50146804
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[36] | |||
| Compound Name |
(Cycloheptylamino)carbonylphosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL97614; SCHEMBL5886552; BDBM50146807
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[36] | |||
| Compound Name |
N-(4-Amino-2-methylquinolin-6-yl)-3-quinolin-8-ylbenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3098999; BDBM50444719
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
(Cyclopropylamino)carbonylphosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL540952; BDBM50146815
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[36] | |||
| Compound Name |
(3-Bromophenylamino)Methylenediphosphonic Acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL370662; BDBM50173799; [(3-Bromophenyl)amino]methylenebisphosphonic acid; [(3-bromoanilino)-phosphono-methyl]phosphonic acid; (3-bromo-phenyl)-aminomethylene-1,1-bisphosphonate; [(3-Bromo-phenylamino)-phosphono-methyl]-phosphonic acid; Phosphonic acid, [[(3-bromophenyl)amino]methylene]bis-
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(5S)-5-Benzyl-1-[(2R)-1-[(2S)-2-[[(6R)-6-benzyl-2,3-dioxopiperazin-1-yl]methyl]pyrrolidin-1-yl]-3-cyclohexylpropan-2-yl]-4-(2-phenylethyl)piperazine-2,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3593552; BDBM50104618
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[39] | |||
| Compound Name |
(Hydroxysulfamoyl)dimethylamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Hydroxysulfonamide 51; CHEMBL330950; SCHEMBL6791061; BDBM11370; N-(Dimethylsulfamoyl)hydroxylamine
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[25] | |||
| Compound Name |
N-(4-Amino-2-methylquinolin-6-yl)-5-methoxy-1H-indole-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3099028; BDBM50444738
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
Chembl4203061
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50456794
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
Chembl4211700
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50456782
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
(4S,5S)-4-Phenylsulfanyl-2-((E)-styryl)-5-vinyl-4,5-dihydro-oxazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL184020; BDBM50152649
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[28] | |||
| Compound Name |
[Anilino(phosphono)methyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440580; SCHEMBL7796889; N-phenylaminomethanediphosphonic acid; BDBM50442523; Phenylaminomethylenebisphosphonic acid; (PHENYLAMINO)METHYLENEDIPHOSPHONIC ACID
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
[2-Methyl-1-[[4-(5-methylthiophen-2-yl)phenyl]sulfonylamino]propyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3752826; BDBM50500715
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[38] | |||
| Compound Name |
(S)-N-(4-Methoxyphenylsulfonyl)-N-(3-pyridylmethyl)-2-amino-4-fluoropent-4-enoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3585772; SCHEMBL13570522; BDBM50093578; (2S)-4-fluoro-2-[(4-methoxyphenyl)sulfonyl-(pyridin-3-ylmethyl)amino]pent-4-enoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[32] | |||
| Compound Name |
Cyclohexanamine;2-methylpropylcarbamoylphosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1160685
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[36] | |||
| Compound Name |
(2R)-N-Hydroxy-2-[[1-[2-[2-[2-[2-[4-[[[(2R)-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl]-(4-methoxyphenyl)sulfonylamino]methyl]triazol-1-yl]ethoxy]ethoxy]ethoxy]ethyl]triazol-4-yl]methyl-(4-methoxyphenyl)sulfonylamino]-3-methylbutanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064553; BDBM50389105
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[43] | |||
| Compound Name |
2-(2-(4-Methoxyphenylsulfonyl)phenyl)acetic Acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL585376; BDBM50299069
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
(4S,5S)-2-p-Tolyl-5-vinyl-4,5-dihydro-oxazole-4-thiol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL362099; BDBM50152637
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[28] | |||
| Compound Name |
[(4-Hydroxyanilino)-phosphonomethyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440438; SCHEMBL4088119; BDBM50442515
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-(3''-Bromo-biphenyl-4-sulfonylamino)-3-methyl-butyric acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL43206; SCHEMBL7409278; BDBM50084299; (S)-2-(3''-bromo-biphenyl-4-sulfonylamino)-3-methyl-butyric acid; (2S)-2-[[4-(3-bromophenyl)phenyl]sulfonylamino]-3-methylbutanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[24] | |||
| Compound Name |
1,1,1-Trifluoro-N-hydroxymethanesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Hydroxysulfonamide 47; CHEMBL331308; SCHEMBL8231627; BDBM11366; CTK1H6610; DTXSID10635307; Methanesulfonamide, 1,1,1-trifluoro-N-hydroxy-
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[25] | |||
| Compound Name |
Cyclohexylcarbamoylphosphonic Acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL329784; (cyclohexylamino)carbonylphosphonic acid; SCHEMBL13986865; BDBM50146801
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[36] | |||
| Compound Name |
CID 78426619
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3235911; SCHEMBL20271444; BDBM50104621
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[39] | |||
| Compound Name |
Thioacetic acid S-[(4S,5S)-2-((E)-styryl)-5-vinyl-4,5-dihydro-oxazol-4-yl] ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL364212; BDBM50152631
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[28] | |||
| Compound Name |
(5S)-5-Benzyl-1-[(2R)-1-cyclohexyl-3-[(2S)-2-[[(6S)-2,3-dioxo-6-propylpiperazin-1-yl]methyl]pyrrolidin-1-yl]propan-2-yl]-4-(2-phenylethyl)piperazine-2,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3593551; BDBM50104620
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[39] | |||
| Compound Name |
N-(2-Methyl-4-amino-6-quinolyl)-3-(2-methoxyphenyl)propionamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3098990; BDBM50444728
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
Chembl4202455
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50456772
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
Chembl4202528
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50456800
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
(2E)-2-(1H-Benzimidazol-2-yl)-3-(3-iodo-4-methoxyphenyl)prop-2-enenitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1933865; BDBM50360392; STK288035; ZINC13943922; AKOS000417983; NCGC00330396-01; AB01325241-02
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
N-(4-Amino-2-methylquinolin-6-yl)-3-[2-(trifluoromethyl)phenyl]propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3099007; BDBM50444711
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
4-Chloroanilinomethylenebisphosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440579; BDBM50442521; ZINC59245747; N-(p-chlorphenyl)-aminomethanediphosphonic acid; (4-CHLOROPHENYLAMINO)METHYLENEDIPHOSPHONIC ACID
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(Sec-butylamino)carbonylphosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL97510; Phosphonic acid, [[(1-methylpropyl)amino]carbonyl]- (9CI); BDBM50146817
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[36] | |||
| Compound Name |
N-(4-Amino-2-methylquinolin-6-yl)-3-(2-methoxypyridin-3-yl)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3098973; BDBM50444760
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
[(4-Fluoro-3-nitroanilino)-phosphonomethyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440434; BDBM50442511
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
3,4-Dichloroanilinomethylenebisphosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440433; BDBM50442512; ZINC96286205; 3,4-DICHLOROPHENYLAMINOMETHYLENEBISPHOSPHONIC ACID
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
1-(4-Amino-2-methylquinolin-6-yl)-3-(4-benzoylphenyl)urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3098982; BDBM50444751
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
2-[(4-Chlorophenyl)methylthio]-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
MLS000062185; CHEMBL473326; SMR000070991; 2-[(4-chlorobenzyl)thio]-3,5,6,7-tetrahydro-4H-cyclopenta[d]pyrimidin-4-one; Oprea1_513869; Oprea1_558114; BDBM40467; cid_2047223; HMS2339I08; ML033; ZINC8602241; BDBM50031314; STL286652; AKOS001659025; CCG-317667; MCULE-1700867569; ST081503; SR-01000464438; SR-01000627583; SR-01000464438-1; SR-01000464438-2; SR-01000627583-2; SR-01000627583-3; Q27165053; 2-[(4-Chlorobenzyl)thio]-6,7-dihydro-5H-cyclopentapyrimidine-4-ol; 2-[(4-chlorobenzyl)thio]-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-4-one; 2-[(4-chlorobenzyl)sulfanyl]-3,5,6,7-tetrahydro-4H-cyclopenta[d]pyrimidin-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[33] | |||
| Compound Name |
(4S,5S)-2-(4-Bromo-phenyl)-5-vinyl-4,5-dihydro-oxazole-4-thiol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL184492; BDBM50152651
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[28] | |||
| Compound Name |
N-Hydroxy-N-{1-(1-isobutyl-piperidin-4-ylidenemethyl)-2-[4-(2-methyl-quinolin-4-ylmethoxy)-benzenesulfonyl]-ethyl}-formamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL318252; SCHEMBL3882021; BDBM50146472
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[44] | |||
| Compound Name |
Chembl4207344
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50456779
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
N-(4-Amino-2-methylquinolin-6-yl)-4-pyridin-3-ylbenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3099030; BDBM50444736
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
(4S,5S)-2-Biphenyl-4-yl-4-phenylsulfanyl-5-vinyl-4,5-dihydro-oxazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL186765; BDBM50152638
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[28] | |||
| Compound Name |
trans-2-Aminocyclohexylcarbamoylphosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL270296; SCHEMBL4854279; BDBM50372742; ZINC29134636; [(1R,2R)-2-aminocyclohexyl]carbamoylphosphonic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[45] | |||
| Compound Name |
[1-[[4-[5-(Methoxymethyl)thiophen-2-yl]phenyl]sulfonylamino]-2-methylpropyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3754314; BDBM50500719
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[38] | |||
| Compound Name |
[(3-Nitroanilino)-phosphono-methyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL450938; SCHEMBL13458525; BDBM50173796; (3-NITROPHENYLAMINO)METHYLENEDIPHOSPHONIC ACID; [(3-Nitro-phenylamino)-phosphono-methyl]-phosphonic acid; Phosphonic acid, [[(3-nitrophenyl)amino]methylene]bis-
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(Cyclobutylamino)carbonylphosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL95763; Phosphonic acid, [(cyclobutylamino)carbonyl]- (9CI); BDBM50146800
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[36] | |||
| Compound Name |
2-(4''-Cyano-biphenyl-4-sulfonylamino)-N-hydroxy-3-methyl-butyramide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL42067; BDBM50084296; (S)-N-Hydroxy-3-methyl-2-[[(4'-cyano-1,1'-biphenyl-4-yl)sulfonyl]amino]butanamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[29] | |||
| Compound Name |
N-[4-[[4-[2-(2,5-Dimethylpyridin-4-yl)ethyl]piperidin-1-yl]sulfonylmethyl]oxan-4-yl]-N-hydroxyformamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1784338; BDBM50345513
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[46] | |||
| Compound Name |
Morpholin-4-ylcarbonylphosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL97838; BDBM50146803
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[36] | |||
| Compound Name |
Cyclopentylcarbamoylphosphonic Acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL316997; (cyclopentylamino)carbonylphosphonic acid; SCHEMBL4846602; CTK8I2608; BDBM50146816
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[36] | |||
| Compound Name |
(4S)-5-Amino-4-[[(2S)-4-methyl-2-[3-[4-(4-phenylphenyl)phenyl]propanoylamino]pentanoyl]amino]-5-oxopentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL6869217; CHEMBL3675580; BDBM120230; US8691753, 79
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[18] | |||
| Compound Name |
Benzyl 6-Benzyl-5,7-Dioxo-6,7-Dihydro-5h-[1,3]thiazolo[3,2-C]pyrimidine-2-Carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
PD-503; CHEMBL409536; SCHEMBL5957461; PD503; BDBM50234334; ZINC29133346; DB08561; Q27097766
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[47] | |||
| Compound Name |
Lithium ethyl (cyclohexylamino)carbonylphosphonate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1627009
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[36] | |||
| Compound Name |
4-{[1-Methyl-2,4-Dioxo-6-(3-Phenylprop-1-Yn-1-Yl)-1,4-Dihydroquinazolin-3(2h)-Yl]methyl}benzoic Acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL496942; MMP Inhibitor, 5; SCHEMBL6244295; ZINC3815953; BDBM50265079; DB07827; DB-123234; SR-03000000793-1; Q27097037
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
(2E)-3-(N-Hydroxycarbamoyl)-2-heptylidenepropionyl-L-tryptophan-N-methylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL236446; BDBM50213418
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[49] | |||
| Compound Name |
[Phosphono-[3-(trifluoromethyl)anilino]methyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440435; BDBM50442514
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Hydroxysulfonamide 48
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL124237; BDBM11367; 1,1,1-trichloro-N-hydroxymethanesulfonamide
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[25] | |||
| Compound Name |
Chembl4214656
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50456793
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
Phenethylcarbamoylphosphonic Acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL24447; [(2-phenylethyl)amino]carbonylphosphonic acid; SCHEMBL13986851; BDBM50112446
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[36] | |||
| Compound Name |
N-(4-Amino-2-methylquinolin-6-yl)-3-quinolin-6-ylbenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3098995; BDBM50444723
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
Chembl4207416
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50456780
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
(R)-2-(4-Fluorophenylsulphonamido-N-(pyridin-3-ylmethyl))-3-methylbutanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL393793; BDBM50225398
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[50] | |||
| Compound Name |
Pentan-3-ylcarbamoylphosphonic Acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL318664; [(1-ethylpropyl)amino]carbonylphosphonic acid; BDBM50146808
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[36] | |||
| Compound Name |
(3R)-6-Cyclohexyl-N-hydroxy-3-(3-{[(methylsulfonyl)amino]-methyl}-1,2,4-oxadiazol-5-yl)hexanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL389020; SCHEMBL5411951; BDBM50216802; (R)-6-cyclohexyl-N-hydroxy-3-(3-(methylsulfonamidomethyl)-1,2,4-oxadiazol-5-yl)hexanamide; (3R)-6-cyclohexyl-N-hydroxy-3-[3-(methanesulfonamidomethyl)-1,2,4-oxadiazol-5-yl]hexanamide
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[44] | |||
| Compound Name |
N-(4-Amino-2-methylquinolin-6-yl)-4-phenoxybenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3099020; BDBM50444747
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
N-Hydroxy-N-[1-(4-methylidenecyclohexyl)-2-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]sulfonylethyl]formamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL328199; SCHEMBL3883897; BDBM50146470
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
[(4-Fluoroanilino)-phosphonomethyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440581; BDBM50442522
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2,6-Difluorobenzyl 6-mercaptopicolinate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL250058; BDBM50227531
Click to Show/Hide
|
||||
| Activity |
IC50 = 101000 nM
|
[9] | |||
| Compound Name |
[4-(Trifluoromethyl)phenyl]methyl 6-oxo-1H-pyridine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1162966; BDBM50371234
Click to Show/Hide
|
||||
| Activity |
IC50 = 101000 nM
|
[9] | |||
| Compound Name |
4-(4-Methoxyphenyl)-N-(2-morpholin-4-ylethyl)thiophene-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL181682; Peakdale1_000543; SCHEMBL6450822; HMS519I15; BDBM50170202; N-(2-Morpholinoethyl)-4-(4-methoxyphenyl)thiophene-2-carboxamide; 4-(4-Methoxy-phenyl)-thiophene-2-carboxylic acid (2-morpholin-4-yl-ethyl)-amide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 101000 nM
|
[51] | |||
| Compound Name |
Naphthalen-2-yl 6-oxo-1,6-dihydropyridine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL253188; BDBM50227545
Click to Show/Hide
|
||||
| Activity |
IC50 = 103000 nM
|
[9] | |||
| Compound Name |
2,4,5-Trifluorobenzyl 6-mercaptopicolinate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL250059; BDBM50227592
Click to Show/Hide
|
||||
| Activity |
IC50 = 105000 nM
|
[9] | |||
| Compound Name |
(5Z)-5-[(2,4-Dihydroxyphenyl)methylidene]-2-sulfanylideneimidazolidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL378575; BDBM11980; BHT102866; chemical diversity library compound 5; AKOS027461626; ST003272; 2-Thioxo-5-[(Z)-2,4-dihydroxybenzylidene]imidazolidine-4-one; 5-[(2,4-dihydroxyphenyl)methylene]-2-thioxo-1,3-diazolidin-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 105900 nM
|
[26] | |||
| Compound Name |
3-Fluorobenzyl 6-mercaptopicolinate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL254611; BDBM50227528
Click to Show/Hide
|
||||
| Activity |
IC50 = 107000 nM
|
[9] | |||
| Compound Name |
Phenethyl 6-mercaptopicolinate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL252522; BDBM50227599
Click to Show/Hide
|
||||
| Activity |
IC50 = 107000 nM
|
[9] | |||
| Compound Name |
Naphthalen-1-yl 6-oxo-1,6-dihydropyridine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL399504; BDBM50227555
Click to Show/Hide
|
||||
| Activity |
IC50 = 109000 nM
|
[9] | |||
| Compound Name |
Hexyl 6-mercaptopicolinate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL249859; BDBM50227581
Click to Show/Hide
|
||||
| Activity |
IC50 = 109000 nM
|
[9] | |||
| Compound Name |
4-Phenoxybenzyl 6-mercaptopicolinate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL250070; BDBM50227532
Click to Show/Hide
|
||||
| Activity |
IC50 = 110000 nM
|
[9] | |||
| Compound Name |
4-Chlorobenzyl 6-mercaptopicolinate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL251081; BDBM50227556
Click to Show/Hide
|
||||
| Activity |
IC50 = 112000 nM
|
[9] | |||
| Compound Name |
3-Phenylpropyl 6-mercaptopicolinate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL252523; BDBM50227542
Click to Show/Hide
|
||||
| Activity |
IC50 = 112000 nM
|
[9] | |||
| Compound Name |
Benzo[d][1,3]dioxol-5-ylmethyl 6-oxo-1,6-dihydropyridine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL253189; BDBM50227540
Click to Show/Hide
|
||||
| Activity |
IC50 = 114000 nM
|
[9] | |||
| Compound Name |
4-Bromobenzyl 6-oxo-1,6-dihydropyridine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL254448; BDBM50227563
Click to Show/Hide
|
||||
| Activity |
IC50 = 114000 nM
|
[9] | |||
| Compound Name |
6-Mercapto-pyridine-2-carboxylic acid 4-methyl-benzyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL254404; BDBM50227582
Click to Show/Hide
|
||||
| Activity |
IC50 = 119000 nM
|
[9] | |||
| Compound Name |
Naphthalen-2-yl 6-mercaptopicolinate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL251424; BDBM50227584
Click to Show/Hide
|
||||
| Activity |
IC50 = 119000 nM
|
[9] | |||
| Compound Name |
4-Fluorobenzyl 6-mercaptopicolinate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL250057; BDBM50227527
Click to Show/Hide
|
||||
| Activity |
IC50 = 120000 nM
|
[9] | |||
| Compound Name |
2,3-Bis(2,4-dimethoxyphenylsulfonamido)-N-hydroxypropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL521689; BDBM50260884
Click to Show/Hide
|
||||
| Activity |
Ki = 124000 nM
|
[52] | |||
| Compound Name |
3-(Trifluoromethyl)benzyl 6-mercaptopicolinate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL254405; BDBM50227535
Click to Show/Hide
|
||||
| Activity |
IC50 = 126000 nM
|
[9] | |||
| Compound Name |
2-Phenoxyethyl 6-oxo-1,6-dihydropyridine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL438519; BDBM50227595
Click to Show/Hide
|
||||
| Activity |
IC50 = 127000 nM
|
[9] | |||
| Compound Name |
Isopropyl 6-mercaptopicolinate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL404205; BDBM50227591
Click to Show/Hide
|
||||
| Activity |
IC50 = 132000 nM
|
[9] | |||
| Compound Name |
Cyclobutyl 6-mercaptopicolinate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL252327; BDBM50227539
Click to Show/Hide
|
||||
| Activity |
IC50 = 137000 nM
|
[9] | |||
| Compound Name |
2,5-Difluorobenzyl 6-mercaptopicolinate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL400449; BDBM50227576
Click to Show/Hide
|
||||
| Activity |
IC50 = 140000 nM
|
[9] | |||
| Compound Name |
4-(Trifluoromethyl)benzyl 6-mercaptopicolinate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL398662; BDBM50227544
Click to Show/Hide
|
||||
| Activity |
IC50 = 141000 nM
|
[9] | |||
| Compound Name |
(2S)-N-Hydroxy-5-oxo-1-[(4-phenylphenyl)methyl]pyrrolidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1957584; BDBM50366185
Click to Show/Hide
|
||||
| Activity |
IC50 = 144000 nM
|
[14] | |||
| Compound Name |
[(2S)-3-[[(2S)-1-Amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-oxo-2-[2-(trifluoromethoxy)phenyl]sulfanylpropyl]-[(1R)-2-phenyl-1-(phenylmethoxycarbonylamino)ethyl]phosphinic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2153738; BDBM50393207
Click to Show/Hide
|
||||
| Activity |
Ki = 148000 nM
|
[53] | |||
| Compound Name |
(1-Benzyloxycarbonylamino-2-phenyl-ethyl)-[2-[1-carbamoyl-2-(1H-indol-3-yl)-ethylcarbamoyl]-3-(2-trifluoromethoxy-phenylsulfanyl)-propyl]-phosphinic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL323885; BDBM50138686
Click to Show/Hide
|
||||
| Activity |
Ki = 148000 nM
|
[54] | |||
| Compound Name |
1-Cinnamyl-4-(4,5-dihydrooxazol-2-yl)-1H-1,2,3-triazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL249249; BDBM50227597
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 150000 nM
|
[9] | |||
| Compound Name |
3-((2-Phenethyl-2H-tetrazol-5-yl)methyl)pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL251465; BDBM50227530
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 150000 nM
|
[9] | |||
| Compound Name |
Naphthalen-1-yl 6-mercaptopicolinate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL251423; BDBM50227543
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 150000 nM
|
[9] | |||
| Compound Name |
4-(4,5-Dihydrooxazol-2-yl)-1-phenethyl-1H-1,2,3-triazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL400851; BDBM50227577
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 150000 nM
|
[9] | |||
| Compound Name |
1-Cyclohexenyl-4-(4,5-dihydrooxazol-2-yl)-1H-1,2,3-triazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL249860; BDBM50227560
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 150000 nM
|
[9] | |||
| Compound Name |
6-Mercapto-pyridine-2-carboxylic acid biphenyl-4-ylmethyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL251425; BDBM50227590
Click to Show/Hide
|
||||
| Activity |
IC50 = 150000 nM
|
[9] | |||
| Compound Name |
4-(4,5-Dihydrooxazol-2-yl)-1-(3-phenylpropyl)-1H-1,2,3-triazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL249863; BDBM50227536
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 150000 nM
|
[9] | |||
| Compound Name |
2-Bromobenzyl 6-mercaptopicolinate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL399997; BDBM50227598
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 150000 nM
|
[9] | |||
| Compound Name |
2,3-Bis(1-(dimethylamino)naphthalene-5-sulfonamido)-N-hydroxypropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL494644; BDBM50260885
Click to Show/Hide
|
||||
| Activity |
Ki = 150000 nM
|
[52] | |||
| Compound Name |
3-((2-Benzyl-2H-tetrazol-5-yl)methyl)pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL400357; BDBM50227573
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 150000 nM
|
[9] | |||
| Compound Name |
4-(4,5-Dihydrooxazol-2-yl)-1-hexyl-1H-1,2,3-triazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL249861; BDBM50227550
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 150000 nM
|
[9] | |||
| Compound Name |
(E)-3-((2-Cinnamyl-2H-tetrazol-5-yl)methyl)pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL428762; BDBM50227546
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 150000 nM
|
[9] | |||
| Compound Name |
4-(4,5-Dihydrooxazol-2-yl)-1-heptyl-1H-1,2,3-triazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL400850; BDBM50227570
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 150000 nM
|
[9] | |||
| Compound Name |
5-(3-Pyridylmethyl)-1H-tetrazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL399998; 3-(2H-tetrazol-5-ylmethyl)pyridine; BDBM50227558; AKOS000262059; 3-((2H-tetrazol-5-yl)methyl)pyridine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 150000 nM
|
[9] | |||
| Compound Name |
1-Benzyl-4-(4,5-dihydrooxazol-2-yl)-1H-1,2,3-triazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL249862; BDBM50227566; J3.517.457E; 1-Benzyl-4-(2-oxazoline-2-yl)-1H-1,2,3-triazole
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 150000 nM
|
[9] | |||
| Compound Name |
3-((2-(3-Phenylpropyl)-2H-tetrazol-5-yl)methyl)pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL400358; BDBM50227594
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 150000 nM
|
[9] | |||
| Compound Name |
N-[(Hydroxyamino)carbonyl]-D-leucyl-Lphenylalanine methylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL452082; BDBM50245247
Click to Show/Hide
|
||||
| Activity |
IC50 = 200000 nM
|
[55] | |||
| Compound Name |
N-[(1S,2S)-2-Hydroxycyclopentyl]-4-phenoxybenzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2380397; BDBM50433870
Click to Show/Hide
|
||||
| Activity |
Ki = 200000 nM
|
[56] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 25 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Clodronate
Click to Show/Hide
|
Approved | Compound Info | ||
| Synonyms |
Bonefos; Clodronsaeure; Dichloromethanediphosphonate; Dichloromethylenebisphosphonate; Methanedichlorodiphosphonate; Acide clodronique; Acido clodronico; Acidum clodronicum; Clodronic Acid; Dichloromethanediphosphonic acid; Dichloromethylene Biphosphonate; Dichloromethylene Diphosphonate; Dichloromethylidene diphosphonate; Liposomes containing clodronic acid; Methanedichlorodiphosphonic acid; Acid, Clodronic; Acid, Dichloromethanediphosphonic; Acide clodronique [INN-French]; Acido clodronico [INN-Spanish]; Acidum clodronicum [INN-Latin]; Biphosphonate, Dichloromethylene; Bonefos (TN); Clodron (TN); Diphosphonate, Dichloromethane; Diphosphonate, Dichloromethylene; Disodium, Clodronate; Loron (TN); Sodium, Clodronate; [dichloro(phosphono)methyl]phosphonic acid; Clodronic acid (USAN/INN); Clodronic acid [USAN:BAN:INN]; Dichlormethylen-bis(phosphonsaeure); Dichloromethylene-1,1-bisphosphonic acid; Dichloromethylene-1,1-diphosphonic acid; Phosphonic acid, (dichloromethylene)di-(8CI); (Dichloro-phosphono-methyl)-phosphonic acid; (Dichloromethylene)bisphosphonic acid; (Dichloromethylene)diphosphonic acid; (Lip-C); (dichloromethanediyl)bis(phosphonic acid)
Click to Show/Hide
|
||||
| Activity |
IC50 = 320000 nM
|
[57] | |||
| Compound Name |
2-(benzyloxyamino)-N-hydroxyacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL226149; 2-(benzyloxyamino)-N-hydroxyacetamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 256000 nM
|
[6] | |||
| Compound Name |
2-(4-chlorobenzyloxyamino)-N-hydroxyacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL227566; 2-(4-chlorobenzyloxyamino)-N-hydroxyacetamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 261000 nM
|
[6] | |||
| Compound Name |
2-(benzyloxyamino)-N-hydroxy-3-methylpentanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL228231; 2-(benzyloxyamino)-N-hydroxy-3-methylpentanamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 352000 nM
|
[6] | |||
| Compound Name |
(4S,5S)-2-(4-Chloro-phenyl)-4-phenylsulfanyl-5-vinyl-4,5-dihydro-oxazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL364322; BDBM50152632
Click to Show/Hide
|
||||
| Activity |
Ki > 200000 nM
|
[28] | |||
| Compound Name |
N-Hydroxy-2,3-bis(perfluorophenylsulfonamido)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL494643; BDBM50260883
Click to Show/Hide
|
||||
| Activity |
Ki = 212000 nM
|
[52] | |||
| Compound Name |
(S)-N-Hydroxy-2,5-bis(4-iodophenylsulfonamido)pentanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL496093; BDBM50260940
Click to Show/Hide
|
||||
| Activity |
Ki = 221000 nM
|
[52] | |||
| Compound Name |
2-(Benzyl-hydroxycarbamoylmethyl-amino)-N-[2-(4-sulfamoyl-phenyl)-ethyl]-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL234737; BDBM50241254; N-Benzyl-N-{[2-(4-sulfamoylphenyl)ethylcarbamoyl]methyl}-aminoacetohydroxamic Acid
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[58] | |||
| Compound Name |
L-Leucyl-L-phenylalanine methylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL445994; h-leu-phe-nhme, AldrichCPR; SCHEMBL7330972; ZINC2386645; BDBM50245250; MFCD01862383; L-leucyl-L-phenylalanine N-methylamide; (2S)-2-AMINO-4-METHYL-N-[(1S)-1-(METHYLCARBAMOYL)-2-PHENYLETHYL]PENTANAMIDE; (2S)-2-amino-4-methyl-N-[(2S)-1-(methylamino)-1-oxo-3-phenylpropan-2-yl]pentanamide
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[55] | |||
| Compound Name |
D-Leucyl-L-phenylalanine methylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL510082; BDBM50245251
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[55] | |||
| Compound Name |
3,2-Diguanidinoneamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
3,2'-diguanidinoneamine; CHEMBL215074; BDBM12005; Neamine guanidinylated deriv. 21
Click to Show/Hide
|
||||
| Activity |
Ki > 300000 nM
|
[59] | |||
| Compound Name |
Neamine guanidinylated deriv. 29
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL215715; BDBM12012; 1,3,2,6-Tetraguanidino-5,6,3,4-tetramethoxylneamine
Click to Show/Hide
|
||||
| Activity |
Ki > 300000 nM
|
[59] | |||
| Compound Name |
Neamine guanidinylated deriv. 4
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL215269; 1,3,2,6-Tetraguanidinoneamine; BDBM11997; 1,3,2',6'-tetraguanidinoneamine
Click to Show/Hide
|
||||
| Activity |
Ki > 300000 nM
|
[59] | |||
| Compound Name |
Z-L-Leu-L-Phe-OMe
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL452584; SCHEMBL7326037; BDBM50245249; N-benzyloxycarbonyl-L-leucyl-L-phenylalanine methyl ester; N-(Benzyloxycarbonyl)-L-leucyl-L-phenylalanine methyl ester; methyl (2S)-2-[[(2S)-4-methyl-2-(phenylmethoxycarbonylamino)pentanoyl]amino]-3-phenylpropanoate
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[55] | |||
| Compound Name |
1,3,2-Triguanidinoneamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
1,3,2'-triguanidinoneamine; CHEMBL438810; BDBM12008; Neamine guanidinylated deriv. 23
Click to Show/Hide
|
||||
| Activity |
Ki > 300000 nM
|
[59] | |||
| Compound Name |
(S)-N-Hydroxy-2,5-bis(4-(trifluoromethyl)phenylsulfonamido)pentanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL496702; BDBM50260913
Click to Show/Hide
|
||||
| Activity |
Ki = 329000 nM
|
[52] | |||
| Compound Name |
Chembl4202548
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50455850
Click to Show/Hide
|
||||
| Activity |
IC50 = 332000 nM
|
[16] | |||
| Compound Name |
(2R)-1-[(4-Chlorophenyl)methyl]-N-hydroxy-5-oxopyrrolidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1957581; BDBM50366182
Click to Show/Hide
|
||||
| Activity |
IC50 = 430000 nM
|
[14] | |||
| Compound Name |
(2R)-2-[(3R)-3-Amino-3-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-2-oxopyrrolidin-1-yl]-N-hydroxy-3-methylbutanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1630098; BDBM50332481
Click to Show/Hide
|
||||
| Activity |
IC50 = 460000 nM
|
[60] | |||
| Compound Name |
2-Amino-5-(4-((thiiran-2-ylmethyl)sulfonyl)phenoxy)phenol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1834423; SCHEMBL2369869; BDBM50354625; 2-amino-5-[4-(thiiran-2-ylmethylsulfonyl)phenoxy]phenol
Click to Show/Hide
|
||||
| Activity |
Ki = 490000 nM
|
[61] | |||
| Compound Name |
(2R)-1-[(2-Chlorophenyl)methyl]-N-hydroxy-5-oxopyrrolidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1957578; BDBM50366179
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[14] | |||
| Compound Name |
(S)-2-Benzenesulfonylamino-N-hydroxy-3-phenyl-propionamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL345135; BDBM50063173
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[7] | |||
| Compound Name |
((4S,5S)-2-Heptyl-5-vinyl-4,5-dihydro-oxazol-4-yl)-methanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL360435; BDBM50152655
Click to Show/Hide
|
||||
| Activity |
Ki > 2000000 nM
|
[28] | |||
| Compound Name |
((4S,5S)-2-Pentyl-5-vinyl-4,5-dihydro-oxazol-4-yl)-methanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL184029; BDBM50152656
Click to Show/Hide
|
||||
| Activity |
Ki > 2000000 nM
|
[28] | |||
| Compound Name |
((4S,5S)-2-Phenyl-5-vinyl-4,5-dihydro-oxazol-4-yl)-methanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL360509; BDBM50152639
Click to Show/Hide
|
||||
| Activity |
Ki > 4000000 nM
|
[28] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Arylamino methylene bisphosphonate derivatives as bone seeking matrix metalloproteinase inhibitors. Bioorg Med Chem. 2013 Nov 1;21(21):6456-65. | ||||
| REF 2 | US patent application no. 9206139B2, Aggrecanase inhibitors | ||||
| REF 3 | Synthesis, experimental evaluation and molecular modelling of hydroxamate derivatives as zinc metalloproteinase inhibitors. Eur J Med Chem. 2016 Jan 27;108:141-153. | ||||
| REF 4 | Small molecule inhibitors of anthrax lethal factor toxin. Bioorg Med Chem. 2014 Jan 1;22(1):419-34. | ||||
| REF 5 | Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment ... Bioorg Med Chem Lett. 2010 Jan 15;20(2):576-80. | ||||
| REF 6 | Carbonic anhydrase and matrix metalloproteinase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozyme I and II with su... Bioorg Med Chem. 2007 Mar 15;15(6):2298-311. | ||||
| REF 7 | Highly selective and orally active inhibitors of type IV collagenase (MMP-9 and MMP-2): N-sulfonylamino acid derivatives. J Med Chem. 1998 Feb 12;41(4):640-9. | ||||
| REF 8 | Potent and selective nonpeptidic inhibitors of procollagen C-proteinase. J Med Chem. 2007 Jul 26;50(15):3442-56. | ||||
| REF 9 | Synthesis and evaluation of novel heterocyclic MMP inhibitors. Bioorg Med Chem Lett. 2007 Dec 15;17(24):6864-70. | ||||
| REF 10 | Antidotes to anthrax lethal factor intoxication. Part 3: Evaluation of core structures and further modifications to the C2-side chain. Bioorg Med Chem Lett. 2012 Mar 15;22(6):2242-6. | ||||
| REF 11 | Tamarixetin 3-O--d-Glucopyranoside from Azadirachta indica Leaves: Gastroprotective Role through Inhibition of Matrix Metalloproteinase-9 Activity in Mice. J Nat Prod. 2017 May 26;80(5):1347-1353. | ||||
| REF 12 | Reverse hydroxamate-based selective TACE inhibitors. Bioorg Med Chem Lett. 2004 Jun 7;14(11):2897-900. | ||||
| REF 13 | Matrix metalloproteinase-12 inhibitors: synthesis, structure-activity relationships and intestinal absorption of novel sugar-based biphenylsulfonamide carboxylates. Bioorg Med Chem. 2018 Dec 1;26(22):5804-5815. | ||||
| REF 14 | In silico scaffold evaluation and solid phase approach to identify new gelatinase inhibitors. Bioorg Med Chem. 2012 Apr 1;20(7):2323-37. | ||||
| REF 15 | Novel 5,5-disubstitutedpyrimidine-2,4,6-triones as selective MMP inhibitors. Bioorg Med Chem Lett. 2001 Apr 23;11(8):969-72. | ||||
| REF 16 | Development of Thioaryl-Based Matrix Metalloproteinase-12 Inhibitors with Alternative Zinc-Binding Groups: Synthesis, Potentiometric, NMR, and Crystallographic Studies. J Med Chem. 2018 May 24;61(10):4421-4435. | ||||
| REF 17 | Protease inhibitors: synthesis of matrix metalloproteinase and bacterial collagenase inhibitors incorporating 5-amino-2-mercapto-1,3,4-thiadiazole ... Bioorg Med Chem Lett. 2002 Oct 7;12(19):2667-72. | ||||
| REF 18 | US patent application no. 8691753B2, Pseudodipeptides as MMP inhibitors | ||||
| REF 19 | Design, synthesis, biological evaluation, and NMR studies of a new series of arylsulfones as selective and potent matrix metalloproteinase-12 inhib... J Med Chem. 2009 Oct 22;52(20):6347-61. | ||||
| REF 20 | Selective arylsulfonamide inhibitors of ADAM-17: hit optimization and activity in ovarian cancer cell models. J Med Chem. 2013 Oct 24;56(20):8089-103. | ||||
| REF 21 | Discovery of dehydroabietic acid sulfonamide based derivatives as selective matrix metalloproteinases inactivators that inhibit cell migration and proliferation. Eur J Med Chem. 2017 Sep 29;138:979-992. | ||||
| REF 22 | O-phenyl carbamate and phenyl urea thiiranes as selective matrix metalloproteinase-2 inhibitors that cross the blood-brain barrier. J Med Chem. 2013 Oct 24;56(20):8139-50. | ||||
| REF 23 | Identification of potential and selective collagenase, gelatinase inhibitors from Crataegus pinnatifida. Bioorg Med Chem Lett. 2010 Feb 1;20(3):991-3. | ||||
| REF 24 | Matrix metalloproteinases (MMPs): chemical-biological functions and (Q)SARs. Bioorg Med Chem. 2007 Mar 15;15(6):2223-68. | ||||
| REF 25 | Carbonic anhydrase and matrix metalloproteinase inhibitors: sulfonylated amino acid hydroxamates with MMP inhibitory properties act as efficient inhibitors of CA isozymes I, II, and IV, and N-hydroxysulfonamides inhibit both these zinc enzymes. J Med Chem. 2000 Oct 5;43(20):3677-87. | ||||
| REF 26 | Novel small-molecule inhibitors of anthrax lethal factor identified by high-throughput screening. J Med Chem. 2006 Aug 24;49(17):5232-44. | ||||
| REF 27 | alpha-Biphenylsulfonylamino 2-methylpropyl phosphonates: enantioselective synthesis and selective inhibition of MMPs. Bioorg Med Chem. 2007 Jan 15;15(2):791-9. | ||||
| REF 28 | Synthesis and evaluation of novel oxazoline MMP inhibitors. Bioorg Med Chem Lett. 2004 Oct 4;14(19):4935-9. | ||||
| REF 29 | Structure-activity relationships and pharmacokinetic analysis for a series of potent, systemically available biphenylsulfonamide matrix metalloproteinase inhibitors. J Med Chem. 2000 Jan 27;43(2):156-66. | ||||
| REF 30 | Structure and activity relationships of tartrate-based TACE inhibitors. Bioorg Med Chem Lett. 2010 Aug 15;20(16):4812-5. | ||||
| REF 31 | Identification of potent and selective TACE inhibitors via the S1 pocket. Bioorg Med Chem Lett. 2007 Jan 1;17(1):34-9. | ||||
| REF 32 | New matrix metalloproteinase inhibitors based on -fluorinated alpha-aminocarboxylic and alpha-aminohydroxamic acids. Bioorg Med Chem. 2015 Jul 1;23(13):3809-18. | ||||
| REF 33 | Ranking the selectivity of PubChem screening hits by activity-based protein profiling: MMP13 as a case study. Bioorg Med Chem. 2009 Feb 1;17(3):1101-8. | ||||
| REF 34 | Lung cancer and matrix metalloproteinases inhibitors of polyphenols from Selaginella tamariscina with suppression activity of migration. Bioorg Med Chem Lett. 2018 Aug 1;28(14):2413-2417. | ||||
| REF 35 | Discovery and SAR of hydantoin TACE inhibitors. Bioorg Med Chem Lett. 2010 Mar 15;20(6):1877-80. | ||||
| REF 36 | Carbamoylphosphonates, a new class of in vivo active matrix metalloproteinase inhibitors. 1. Alkyl- and cycloalkylcarbamoylphosphonic acids. J Med Chem. 2004 May 20;47(11):2826-32. | ||||
| REF 37 | Selective non zinc binding inhibitors of MMP13. Bioorg Med Chem Lett. 2011 Jul 15;21(14):4215-9. | ||||
| REF 38 | Fluorinated matrix metalloproteinases inhibitors--Phosphonate based potential probes for positron emission tomography. Bioorg Med Chem. 2016 Feb 15;24(4):902-9. | ||||
| REF 39 | SAR Studies of Exosite-Binding Substrate-Selective Inhibitors of A Disintegrin And Metalloprotease 17 (ADAM17) and Application as Selective in Vitro Probes. J Med Chem. 2015 Aug 13;58(15):5808-24. | ||||
| REF 40 | Time-dependent botulinum neurotoxin serotype A metalloprotease inhibitors. Bioorg Med Chem. 2011 Dec 15;19(24):7338-48. | ||||
| REF 41 | Lead optimisation of selective non-zinc binding inhibitors of MMP13. Part 2. Bioorg Med Chem Lett. 2012 Jan 1;22(1):271-7. | ||||
| REF 42 | Design and synthesis of an activity-based protein profiling probe derived from cinnamic hydroxamic acid. Bioorg Med Chem. 2016 Feb 15;24(4):686-92. | ||||
| REF 43 | A new class of highly potent matrix metalloproteinase inhibitors based on triazole-substituted hydroxamates: (radio)synthesis and in vitro and first in vivo evaluation. J Med Chem. 2012 May 24;55(10):4714-27. | ||||
| REF 44 | Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge. Bioorg Med Chem. 2008 Oct 1;16(19):8781-94. | ||||
| REF 45 | Carbamoylphosphonate matrix metalloproteinase inhibitors 6: cis-2-aminocyclohexylcarbamoylphosphonic acid, a novel orally active antimetastatic mat... J Med Chem. 2008 Mar 13;51(5):1406-14. | ||||
| REF 46 | Orally active achiral N-hydroxyformamide inhibitors of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) for the treatment of osteoarthritis. Bioorg Med Chem Lett. 2011 Jun 1;21(11):3301-6. | ||||
| REF 47 | Quinazolinones and pyrido[3,4-d]pyrimidin-4-ones as orally active and specific matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis. J Med Chem. 2008 Feb 28;51(4):835-41. | ||||
| REF 48 | Discovery and characterization of a novel inhibitor of matrix metalloprotease-13 that reduces cartilage damage in vivo without joint fibroplasia si... J Biol Chem. 2007 Sep 21;282(38):27781-91. | ||||
| REF 49 | Simultaneous presence of unsaturation and long alkyl chain at P'1 of Ilomastat confers selectivity for gelatinase A (MMP-2) over gelatinase B (MMP-9) inhibition as shown by molecular modelling studies. Bioorg Med Chem. 2007 Jul 15;15(14):4753-66. | ||||
| REF 50 | Novel fluorinated derivatives of the broad-spectrum MMP inhibitors N-hydroxy-2(R)-[[(4-methoxyphenyl)sulfonyl](benzyl)- and (3-picolyl)-amino]-3-methyl-butanamide as potential tools for the molecular imaging of activated MMPs with PET. J Med Chem. 2007 Nov 15;50(23):5752-64. | ||||
| REF 51 | Structure-based design and synthesis of novel non-zinc chelating MMP-12 inhibitors. Bioorg Med Chem Lett. 2005 Aug 15;15(16):3787-90. | ||||
| REF 52 | Novel bis-(arylsulfonamide) hydroxamate-based selective MMP inhibitors. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3333-7. | ||||
| REF 53 | Remarkable potential of the alpha-aminophosphonate/phosphinate structural motif in medicinal chemistry. J Med Chem. 2011 Sep 8;54(17):5955-80. | ||||
| REF 54 | Evaluation of P1'-diversified phosphinic peptides leads to the development of highly selective inhibitors of MMP-11. J Med Chem. 2004 Jan 15;47(2):325-36. | ||||
| REF 55 | Peptidyl 3-substituted 1-hydroxyureas as isosteric analogues of succinylhydroxamate MMP inhibitors. Eur J Med Chem. 2008 May;43(5):1008-14. | ||||
| REF 56 | Matrix metalloproteinase inhibitors based on the 3-mercaptopyrrolidine core. J Med Chem. 2013 Jun 13;56(11):4357-73. | ||||
| REF 57 | Platinum complexes can inhibit matrix metalloproteinase activity: platinum-diethyl[(methylsulfinyl)methyl]phosphonate complexes as inhibitors of matrix metalloproteinases 2, 3, 9, and 12. J Med Chem. 2007 Jul 26;50(15):3434-41. | ||||
| REF 58 | Dual inhibitors of matrix metalloproteinases and carbonic anhydrases: iminodiacetyl-based hydroxamate-benzenesulfonamide conjugates. J Med Chem. 2008 Dec 25;51(24):7968-79. | ||||
| REF 59 | Selectively guanidinylated derivatives of neamine. Syntheses and inhibition of anthrax lethal factor protease. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5183-9. | ||||
| REF 60 | Structure based optimization of chromen-based TNF-alpha converting enzyme (TACE) inhibitors on S1' pocket and their quantitative structure-activity relationship (QSAR) study. Bioorg Med Chem. 2010 Dec 15;18(24):8618-29. | ||||
| REF 61 | Selective water-soluble gelatinase inhibitor prodrugs. J Med Chem. 2011 Oct 13;54(19):6676-90. | ||||
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