Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T54582 | Target Info | |||
| Target Name | Nicotinamide phosphoribosyltransferase (NAMPT) | ||||
| Synonyms |
Visfatin; PreBcell colonyenhancing factor 1; PreB cellenhancing factor; Pre-B-cell colony-enhancing factor 1; Pre-B cell-enhancing factor; PBEF1; PBEF; Nampt; NAmPRTase
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| Target Type | Clinical trial Target | ||||
| Gene Name | NAMPT | ||||
| Biochemical Class | Glycosyltransferases | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 26 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
3-Methyl-N-(pyridin-3-yl)thiophene-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3112695; SCHEMBL13270385; BDBM50447571; ZINC40459471; AKOS016722787; MCULE-4156059081; Z31791483
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| Activity |
IC50 = 50000 nM
|
[1] | |||
| Compound Name |
4-[(4-Chlorophenyl)sulfonylamino]-N-pyridin-3-ylbenzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3116419; BDBM50447597
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| Activity |
IC50 = 62000 nM
|
[1] | |||
| Compound Name |
4-[[(4-Tert-butylbenzoyl)amino]methyl]-N-pyridin-3-ylbenzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3116422; SCHEMBL1048281; BDBM50447594; ZINC96341509; AKOS016675753; MCULE-7078860278
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| Activity |
IC50 = 80000 nM
|
[1] | |||
| Compound Name |
4-(4-Methylbenzenesulfonamido)-N-(pyridin-3-yl)benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3116415; ZINC1059924; BDBM50447601; STL114363; AKOS000395020; CCG-324475; MCULE-3769438230; SDCCGSBI-0126544.P001; Z57695216; 4-{[(4-methylphenyl)sulfonyl]amino}-N-(pyridin-3-yl)benzamide
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| Activity |
IC50 = 83000 nM
|
[1] | |||
| Compound Name |
Chembl4216048
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL13373422; BDBM50453375; AKOS005218566; AKOS027641606
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| Activity |
IC50 = 90000 nM
|
[2] | |||
| Compound Name |
1-Methyl-N-(pyridin-3-yl)-1H-pyrazole-5-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1494030; Cambridge id 6540033; Oprea1_069221; Oprea1_487160; MLS000072660; 2-Methyl-2H-pyrazole-3-carboxylic acid pyridin-3-ylamide; HMS1681M17; HMS2504G11; ZINC138552; BDBM50447577; STK048549; AKOS003594981; MCULE-1292648087; SMR000011777; ST031141; (1-methylpyrazol-5-yl)-N-(3-pyridyl)carboxamide; SR-01000317466; SR-01000317466-1; Q27453010
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| Activity |
IC50 = 91000 nM
|
[1] | |||
| Compound Name |
1,5-Dimethyl-N-pyridin-3-ylpyrrole-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3112698; BDBM50447568
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
1-Methyl-N-pyridin-3-ylimidazole-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3112691; BDBM50447575
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
3-Methyl-N-pyridin-3-ylbenzimidazole-5-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3116431; BDBM50447585
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-(Aminomethyl)-N-pyridin-3-ylbenzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3116406; SCHEMBL12077252; CTK7E4364; BDBM50447611; ZINC21968165; AKOS000130696; MCULE-6552710519; 4-(aminomethyl)-N-(3-pyridinyl)benzamide; 4-(AMINOMETHYL)-N-(PYRIDIN-3-YL)BENZAMIDE
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-Amino-n-pyridin-3-ylbenzamide
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Investigative | Compound Info | ||
| Synonyms |
4-amino-N-(pyridin-3-yl)benzamide; 4-AMINO-N-3-PYRIDINYLBENZAMIDE; Benzamide, 4-amino-N-3-pyridinyl-; CHEMBL3112706; 4-amino-N-pyridin-3-yl-benzamide; SCHEMBL3403542; CTK4B7400; DTXSID80276903; BBL009606; BDBM50447614; MFCD09046746; STK497964; ZINC12540155; AKOS000100220; MCULE-7971640137; VS-02108; BB 0217309; EN300-33559; Y-4910; J-006026; Z361993858
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-[(1-Benzoylpiperidin-4-yl)methyl]-1-methyl-N-pyridin-3-ylbenzimidazole-5-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3116403; BDBM50447578
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
1-Ethyl-3-methyl-N-(pyridin-3-yl)-1H-pyrazole-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3112703; BDBM50447563; ZINC12949820; AKOS003745168
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
5-Methyl-N-pyridin-3-yl-1,3-thiazole-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3112693; BDBM50447573
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-(Benzenesulfonamido)-N-pyridin-3-ylbenzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3112628; SCHEMBL12078328; ZINC4809340; BDBM50447605; STL071824; AKOS000394865; MCULE-9540042150; 4-[(phenylsulfonyl)amino]-N-(pyridin-3-yl)benzamide
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
5-Methyl-N-pyridin-3-yl-1,3-oxazole-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3112694; BDBM50447572
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
3-Benzyl-N-pyridin-3-ylbenzimidazole-5-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3116432; BDBM50447584
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
1,3-Dimethyl-N-(pyridin-3-yl)-1H-pyrazole-4-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3112702; BDBM50447564
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2,3-Dimethyl-N-pyridin-3-ylimidazole-4-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3112701; SCHEMBL19541138; BDBM50447565
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
5-Ethyl-2-methyl-N-pyridin-3-ylpyrazole-3-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3112704; BDBM50447562
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-Methyl-N-pyridin-3-yl-1,3-thiazole-5-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3112696; BDBM50447570
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
1-Ethyl-5-methyl-N-pyridin-3-ylpyrazole-4-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3112699; BDBM50447567
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
N-Pyridin-3-yl-1H-pyrazole-5-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3116433; SCHEMBL11039238; BDBM50447576
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Tert-butyl 4-[[1-methyl-5-(pyridin-3-ylcarbamoyl)benzimidazol-2-yl]methyl]piperidine-1-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3116402; BDBM50447579
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
5-Methyl-1-phenyl-N-(pyridin-3-yl)-1H-pyrazole-4-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3112700; BDBM50447566; STL245312; ZINC10742130; AKOS025282639; MCULE-1504894065; Z194863184
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
3-Methyl-N-pyridin-3-ylfuran-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3112697; BDBM50447569; AKOS033801694; MCULE-3346112689
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 3 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-[(2-Fluorophenyl)amino]-6-propylpyrimidin-4(3H)-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4210011; 2-((2-fluorophenyl)amino)-6-propylpyrimidin-4(3H)-one; ZINC5182435; BDBM50453373; AKOS002321811; MCULE-9823983784; ST50327123; F3284-7017; 2-[(2-fluorophenyl)amino]-6-propyl-3-hydropyrimidin-4-one
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| Activity |
IC50 = 360000 nM
|
[2] | |||
| Compound Name |
Chembl4214925
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50453372; AKOS027616186
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|
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| Activity |
IC50 = 850000 nM
|
[2] | |||
| Compound Name |
Chembl4215353
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50453371
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|
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| Activity |
IC50 > 1000000 nM
|
[2] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Fragment-based design of 3-aminopyridine-derived amides as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). Bioorg Med Chem Lett. 2014 Feb 1;24(3):954-62. | ||||
| REF 2 | Fragment-based discovery of a potent NAMPT inhibitor. Bioorg Med Chem Lett. 2018 Feb 1;28(3):437-440. | ||||
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