Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T55293 | Target Info | |||
| Target Name | Integrin alpha-2 (ITGA2) | ||||
| Synonyms |
VLA-2 subunit alpha; VLA-2 alphachain; VLA-2; Platelet membrane glycoprotein Ia; Platelet glycoprotein Ia/IIa; Glycoprotein Ia-IIa; GPIa/IIa; GPIa; Collagen receptor; CD49b; CD49 antigen-like family member B; Adhesive platelet receptor alpha1 beta2
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| Target Type | Clinical trial Target | ||||
| Gene Name | ITGA2 | ||||
| Biochemical Class | Integrin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 2 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Methyl 2-ethyl-4,5,7-trihydroxy-6,11-dioxotetracene-1-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL225917; SCHEMBL4389004; BDBM50370964
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| Activity |
IC50 = 50000 nM
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[1] | |||
| Compound Name |
(R)-3-(Furan-3-carboxamido)-2-(2-methoxyphenylsulfonamido)propanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL550395; BDBM50296634
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Small molecule designed to target metal binding site in the alpha2I domain inhibits integrin function. J Med Chem. 2007 May 31;50(11):2742-6. | ||||
| REF 2 | Novel inhibitors of the alphavbeta3 integrin--lead identification strategy. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4832-5. | ||||
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