Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T56367 | Target Info | |||
| Target Name | Phosphodiesterase 1 (PDE1) | ||||
| Synonyms |
PDE-I; Cam-PDE 1
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| Target Type | Successful Target | ||||
| Gene Name | NO-GeName | ||||
| Biochemical Class | Phosphoric diester hydrolase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 83 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Dipyridamole
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|
Approved | Compound Info | ||
| Synonyms |
Agilease; Anginal; Antistenocardin; Apricor; Cardioflux; Cardoxil; Cardoxin; Cerebrovase; Chilcolan; Cleridium; Coribon; Coridil; Coronarine; Corosan; Coroxin; Curantil; Curantyl; Dipiridamol; Dipyramidole; Dipyridamine; Dipyridamol; Dipyridamolum; Dipyridan; Dipyudamine; Dypyridamol; Gulliostin; Justpertin; Kurantil; Miosen; Natyl; Peridamol; Permiltin; Persantin; Persantine; Piroan; Prandiol; Protangix; Stenocardil; Stenocardiol; Stimolcardio; Apotex Brand of Dipyridamole; Ashbourne Brand of Dipyridamole; Belmac Brand of Dipyridamole; Berlin Chemie Brand of Dipyridamole; Boehringer Ingelheim Brand of Dipyridamole; IPRAD Brand of Dipyridamole; Iv Persantine; Novopharm Brand of Dipyridamole; Cleridium 150; D 9766; Prandiol 75; Apo-Dipyridamole; Apo-Dipyridamole Fc; Apo-Dipyridamole Sc; Berlin-Chemie Brand of Dipyridamole; Dipiridamol [INN-Spanish]; Dipyridamolum [INN-Latin]; Novo-Dipiradol; Persantine (TN); RA-8; Usaf Ge-12; Dipyridamole (JP15/USP/INN); Dipyridamole [USAN:INN:BAN:JAN]; Permole, Persantine, Dipyridan, Dipyridamole; 2,6-Bis(diethanolamine)-4,8-dipiperidinopyrimido[5,4-d]pyrimidine; 2,6-Bis(diethanolamino)-4,8-dipiperidinopyrimido(5,4-d)pyrimidine; 2,6-Bis(diethanolamino)-4,8-dipiperidinopyrimido[5,4-d]pyrimidine
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Milrinone
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|
Approved | Compound Info | ||
| Synonyms |
Corotrop; Corotrope; Milrila; Milrinona; Milrinonum; Primacor; Milrinona [Spanish]; Milrinonum [Latin]; M 4659; M1663; YM 018; MILRINONE LACTATE IN DEXTROSE 5% IN PLASTIC CONTAINER; Milrila (TN); PRIMACOR IN DEXTROSE 5% IN PLASTIC CONTAINER; Primacor (TN); WIN 47203-2; Win-47203; Milrinone [USAN:BAN:INN]; Win-47203-2; Milrinone (JAN/USAN/INN); 1,6-Dihydro-2-methyl-6-oxo(3,4'-bipyridine)-5-carbonitrile; 1,6-Dihydro-2-methyl-6-oxo-(3,4′-bipyridine)-5-carbonitrile; 1,6-Dihydro-2-methyl-6-oxo-(3,4'-bipyridine)-5-carbonitrile; 1,6-Dihydro-2-methyl-6-oxo-3,4-bipyridine-5-carbonitrile; 1,6-Dihydro-2-methyl-6-oxo-[3,4'-bipyridine]-5-carbonitrile; 111GE027; 2-methyl-6-oxo-1,6-dihydro-3,4'-bipyridine-5-carbonitrile; 3-Cyano-6-methyl-5-(4-pyridyl)-2-pyridone; 6-Methyl-5-(4-pyridyl)-2-pyridone-3-carbonitrile; 6-methyl-2-oxo-5-pyridin-4-yl-1H-pyridine-3-carbonitrile
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| Activity |
IC50 = 198000 nM
|
[2] | |||
| Compound Name |
ROLIPRAM
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Phase 2 | Compound Info | ||
| Synonyms |
61413-54-5; ZK 62711; Rolipramum; Rolipramum [Latin]; 4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone; Adeo; Rolipram [USAN:INN]; 4-[3-(cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one; 4-(3-(cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one; 4-(3-(Cyclopentyloxy)-4-methoxyphenyl)-2-pyrrolidinone; (R,S)-rolipram; ZK-62711; CHEMBL63; EINECS 262-771-1; BRN 1588548; MLS000069691; CHEBI:104872; HJORMJIFDVBMOB-UHFFFAOYSA-N; 4-(3-Cyclopentyloxy-4-methoxyphenyl)-2-pyrrolidone; [3H]rolipram
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
CI-930
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Discontinued in Phase 2 | Compound Info | ||
| Synonyms |
CI-930; CI 930; 86798-59-6; 4,5-dihydro-6-(4-(imidazol-1-yl)phenyl)-5-methyl-3(2H)-pyridazinone; 3(2H)-Pyridazinone, 4,5-dihydro-6-(4-(1H-imidazol-1-yl)phenyl)-5-methyl-; AC1MIBTH; CHEMBL440593; SCHEMBL6052113; CTK5F7194; BDBM14362; AEZZPAQOEUQNBB-UHFFFAOYSA-N; 90791-23-4 (hydrochloride); BDBM50225945; LS-187480; LS-186812; 6-[4-(1-Imidazolyl)phenyl]-5-methyl-3-oxo-2,3,4,5-tetrahydropyridazine; 3-(4-imidazol-1-ylphenyl)-4-methyl-4,5-dihydro-1H-pyridazin-6-one
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
TETRAHYDROBENXIMIDAZOLE
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL282765; TETRAHYDROBENXIMIDAZOLE; SCHEMBL10625034; KDEKNYKHIZTSLE-UHFFFAOYSA-N; BDBM50016839; 4,5-dihydro-6-[4-(4,5,6,7-tetrahydro-1H-benzimidazol-1-yl)phenyl]-5-methyl-3(2H)-pyridazinone
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| Activity |
IC50 = 75000 nM
|
[5] | |||
| Compound Name |
2-Tert-butyl-8-methyl-6-(2-methylpropyl)-3H-imidazo[4,5-f]quinazoline-7,9-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL369824; BDBM50405457
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
[4-(3-Amino-4,5-dimethoxyphenyl)-6,7-diethoxy-3-(hydroxymethyl)naphthalen-2-yl]methanol;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL542178
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|
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| Activity |
IC50 = 50000 nM
|
[7] | |||
| Compound Name |
1-[2-(2-Oxo-1,2-dihydropyridine-1-yl)-4-pyridinyl]-6,7-dimethoxynaphthalene-2,3-dimethanol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL12599; BDBM50074890; 4''-(2,3-Bis-hydroxymethyl-6,7-dimethoxy-naphthalen-1-yl)-[1,2'']bipyridinyl-2-one
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| Activity |
IC50 = 50000 nM
|
[3] | |||
| Compound Name |
6-Methoxy-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-12-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL109754; SCHEMBL7490467; BDBM50223645; ZINC26975777
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| Activity |
IC50 = 52000 nM
|
[8] | |||
| Compound Name |
2-(Methoxymethyl)-8-methyl-6-(2-methylpropyl)-3H-imidazo[4,5-f]quinazoline-7,9-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL175958; BDBM50405449
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| Activity |
IC50 = 54000 nM
|
[6] | |||
| Compound Name |
1-(1,3-Benzodioxole-5-yl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-6,7-dimethoxy-2-naphthoic acid methyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL25356; BDBM50075696
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| Activity |
IC50 = 55000 nM
|
[9] | |||
| Compound Name |
[3-Hydroxymethyl-6,7-dimethoxy-1-(3,4,5-trimethoxy-phenyl)-naphthalen-2-yl]-methanol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL285361; BDBM50052098; 1-(3,4,5-Trimethoxyphenyl)-6,7-dimethoxy-2,3-naphthalenedimethanol
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| Activity |
IC50 = 60000 nM
|
[7] | |||
| Compound Name |
1-(3-Bromo-4,5-dimethoxyphenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-6-ethoxy-7-methoxy-2-naphthoic acid methyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL24495; BDBM50075698
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| Activity |
IC50 = 61000 nM
|
[9] | |||
| Compound Name |
1-(3,4,5-Trimethoxyphenyl)-3-[(4-methylpiperazino)carbonyl]-6,7-dimethoxy-2-naphthoic acid methyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL24659; BDBM50075706
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| Activity |
IC50 = 69000 nM
|
[9] | |||
| Compound Name |
[1-(3,4-Dimethoxy-phenyl)-3-hydroxymethyl-6,7-dimethoxy-naphthalen-2-yl]-methanol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL91778; CTK1B2902; DTXSID50472950; BDBM50052087; 1-(3,4-Dimethoxyphenyl)-6,7-dimethoxynaphthalene-2,3-dimethanol; 2,3-Naphthalenedimethanol, 1-(3,4-dimethoxyphenyl)-6,7-dimethoxy-
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| Activity |
IC50 = 70000 nM
|
[7] | |||
| Compound Name |
8-Chloro-5-[2-(methylamino)ethoxy]spiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL184979; BDBM50151642
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| Activity |
IC50 = 72400 nM
|
[10] | |||
| Compound Name |
1-(3,4,5-Trimethoxyphenyl)-3-[(4-hydroxypiperidino)carbonyl]-6,7-dimethoxy-2-naphthoic acid methyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL24719; BDBM50075708
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| Activity |
IC50 = 74000 nM
|
[9] | |||
| Compound Name |
1-(2-Bromo-4-pyridyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-6,7-dimethoxy-2-naphthoic acid methyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL24801; BDBM50075692
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| Activity |
IC50 = 75000 nM
|
[9] | |||
| Compound Name |
1-(2-Thienyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-6,7-dimethoxy-2-naphthoic acid methyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL26622; BDBM50075709
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| Activity |
IC50 = 77000 nM
|
[9] | |||
| Compound Name |
4,5-Dihydro-6-[4-(2-ethyl-4-methyl-1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinone
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL30908; SCHEMBL7288026; BDBM50018615; 3-[4-(2-ethyl-4-methylimidazol-1-yl)phenyl]-4,5-dihydro-1H-pyridazin-6-one; 4,5-dihydro-6-[4-(2-ethyl-4-methyl-1H-imidazol-1-yl)-phenyl]-3(2H)-pyridazinone; 6-[4-(2-Ethyl-4-methyl-imidazol-1-yl)-phenyl]-4,5-dihydro-2H-pyridazin-3-one
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| Activity |
IC50 = 80000 nM
|
[5] | |||
| Compound Name |
5-(4-Chlorophenyl)-N-(4-fluorophenyl)-3-methyl-1,3,4-thiadiazol-2-imine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL362719; SCHEMBL4250388; SCHEMBL4250390; BDBM50151559; [5-(4-Chloro-phenyl)-3-methyl-3H-[1,3,4]thiadiazol-(2Z)-ylidene]-(4-fluoro-phenyl)-amine
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| Activity |
IC50 = 85680 nM
|
[11] | |||
| Compound Name |
1-Isoamyl-3-isobutylxanthine
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Investigative | Compound Info | ||
| Synonyms |
UNII-976SW405SB; CHEMBL20613; 976SW405SB; 1-(3-methylbutyl)-3-(2-methylpropyl)-7H-purine-2,6-dione; 3-Isobutyl-1-isoamylxanthine; SCHEMBL10579248; CTK5C0165; DTXSID30213606; ZINC5114421; BDBM50018154; Q27271973; 3-Isobutyl-1-(3-methyl-butyl)-3,7-dihydro-purine-2,6-dione; 1H-Purine-2,6-dione, 3,7-dihydro-1-(3-methylbutyl)-3-(2-methylpropyl)-; 1H-Purine-2,6-dione,3,9-dihydro-1-(3-methylbutyl)-3-(2-methylpropyl)-
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| Activity |
IC50 = 86000 nM
|
[6] | |||
| Compound Name |
1-(3,4,5-Trimethoxyphenyl)-3-[(4-oxopiperidino)carbonyl]-6,7-dimethoxy-2-naphthoic acid methyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL23990; BDBM50075702
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| Activity |
IC50 = 88000 nM
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[9] | |||
| Compound Name |
1-(3,4-Dichlorophenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-6,7-dimethoxy-2-naphthoic acid methyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL431107; BDBM50075697
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| Activity |
IC50 = 89000 nM
|
[9] | |||
| Compound Name |
1-(2-Methyl-4,5-dimethoxyphenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-6,7-dimethoxy-2-naphthoic acid methyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL282371; BDBM50075700
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| Activity |
IC50 = 97000 nM
|
[9] | |||
| Compound Name |
1-(3-Bromo-4,5-dimethoxyphenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-6,7,8-trimethoxy-2-naphthoic acid methyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL24327; BDBM50075718
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| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
3,4-Dipropyl-8,9-dihydro-7H-pyrimido[2,1-f]purin-5-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL109550; BDBM50471411; 3,4-Dipropyl-3,4,5,7,8,9-hexahydropyrimido[2,1-i]purine-5-one
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| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
6,9-Dipropyltetrazolo[5,1-f]purin-5-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL322358; BDBM50471410; 6,9-Dipropyl-6,9-dihydro-5H-tetrazolo[5,1-i]purin-5-one
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| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
6-Methoxy-9-phenyl-1,7,10-triazatricyclo[6.4.1.04,13]trideca-4,6,8(13),9-tetraen-12-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL113368; SCHEMBL6441960; BDBM50147632; 4-Methoxy-6-phenyl-1,2-dihydro-8H-5,7,9a-triaza-benzo[cd]azulen-9-one
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| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
4-(2,3-Bis-hydroxymethyl-6,7-dimethoxy-naphthalen-1-yl)-1-methyl-3,6-dihydro-1H-pyridin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL329574; BDBM50052100
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| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
T 0156 Hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
T-0156 hydrochloride; t-0156; CHEMBL540294; SR-01000076180; SCHEMBL1148363; CTK8I2006; AKOS024456743; NCGC00094459-01; EU-0101212; T 8067; SR-01000076180-1; SR-01000076180-3; Q15634075
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| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
1-Phthalazinamine, N-(3-chlorophenyl)-4-phenyl-
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Investigative | Compound Info | ||
| Synonyms |
MY-5445; 1-(3-Chloroanilino)-4-phenylphthalazine; MY 5445; 1-(3-chlorophenylamino)-4-phenylphthalazine; n-(3-chlorophenyl)-4-phenylphthalazin-1-amine; UNII-F8CSS73B6A; F8CSS73B6A; CHEMBL332898; Tocris-0432; SpecPlus_000807; Spectrum2_001820; Spectrum3_001763; BSPBio_001360; BSPBio_003225; KBioGR_000080; KBioSS_000080; DivK1c_006903; SPBio_001839; SCHEMBL1752920; CTK2H7315; KBio1_001847; KBio2_000080; KBio2_002648; KBio2_005216; KBio3_000159; KBio3_000160; KBio3_002725; DTXSID70229009; Bio2_000080; Bio2_000560; HMS1361D22; HMS1791D22; HMS1989D22; HMS3266O13; HMS3402D22; HMS3411K15; HMS3675K15; ZINC2557949; BDBM50020874; MFCD00209838; AKOS024458091; IDI1_033830; SMP2_000185; NCGC00024587-01; NCGC00024587-02; NCGC00024587-03; NCGC00024587-04; NCGC00024587-05; HY-100933; 1-(3-Chlorophenyl)amino-4-phenylphthalazine; B6301; CS-0020604; (3-chlorophenyl)-(4-phenylphthalazin-1-yl)amine; SR-01000597645; SR-01000597645-1; (3-Chloro-phenyl)-(4-phenyl-phthalazin-1-yl)-amine; BRD-K90524085-001-05-2; BRD-K90524085-001-06-0; Q15634077
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-Propyl-1,4-dihydro-5H-imidazo[2,1-i]purin-5-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL326285; BDBM50471418
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| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
1-(3-Amino-4,5-dimethoxyphenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-6,7-dimethoxy-2-naphthoic acid methyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL26054; BDBM50075717
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| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
4-[[(1,3-Benzodioxol-5-yl)methyl]amino]quinazoline-6-carbonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL67243; SCHEMBL7503578; BDBM50038992; 4-(3,4-Methylenedioxybenzyl)amino-6-cyanoquinazoline; 4-(1,3-benzodioxol-5-ylmethylamino)quinazoline-6-carbonitrile; 4-[(Benzo[1,3]dioxol-5-ylmethyl)-amino]-quinazoline-6-carbonitrile
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| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
[3-Hydroxymethyl-1-(3-methanesulfonyl-4,5-dimethoxy-phenyl)-6,7-dimethoxy-naphthalen-2-yl]-methanol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL91064; BDBM50052081; 1-[3-(Methylsulfonyl)-4,5-dimethoxyphenyl]-6,7-dimethoxynaphthalene-2,3-dimethanol
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| Activity |
IC50 = 100000 nM
|
[7] | |||
| Compound Name |
5-(2,3-Bis-hydroxymethyl-6,7-dimethoxy-naphthalen-1-yl)-2,3-dimethoxy-N,N-dimethyl-benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL90059; BDBM50052097; 1-[3-(Dimethylcarbamoyl)-4,5-dimethoxyphenyl]-6,7-dimethoxynaphthalene-2,3-dimethanol
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| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-[3-hydroxymethyl-6,7-dimethoxy-4-(3,4,5-trimethoxy-phenyl)-naphthalen-2-yl]-methanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL281771; BDBM50075715
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| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
1-(3,4,5-Trimethoxyphenyl)-3-(methylcarbamoyl)-6,7-dimethoxy-2-naphthoic acid methyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL26493; BDBM50075714
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| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
1-(3-Bromo-4,5-dimethoxyphenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-5-chloro-2-naphthoic acid methyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL24752; SCHEMBL19197655; BDBM50075691
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| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
2-[5-[2,3-Bis(hydroxymethyl)-6,7-dimethoxynaphthalen-1-yl]pyridin-2-yl]-4-pyridin-3-ylphthalazin-1-one;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL536785
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
1,4-Dipropyl-7,8-dihydroimidazo[2,1-f]purin-5-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL111486; BDBM50471413; 1,4-Dipropyl-1,4,7,8-tetrahydro-5H-imidazo[2,1-i]purin-5-one
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| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
6,7-Dipropyltetrazolo[5,1-f]purin-5-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL320350; BDBM50471422; 6,7-Dipropyl-6,7-dihydro-5H-tetrazolo[5,1-i]purin-5-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
3,4-Dipropyl-7,8,9,10-tetrahydro-[1,3]diazepino[2,1-f]purin-5-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL109427; BDBM50471408; 3,4-Dipropyl-3,4,7,8,9,10-hexahydro-5H-[1,3]diazepino[2,1-i]purin-5-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
(3-Hydroxymethyl-6,7-dimethoxy-naphthalen-2-yl)-methanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL90974; BDBM50052089; ZINC13756799; 6,7-Dimethoxynaphthalene-2,3-dimethanol
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
Benzo[1,3]dioxol-5-ylmethyl-(6-methyl-quinazolin-4-yl)-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL67276; SCHEMBL7493988; BDBM50038973; N-(1,3-benzodioxol-5-ylmethyl)-6-methylquinazolin-4-amine; N-[(1,3-Benzodioxol-5-yl)methyl]-6-methylquinazolin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
1-(3,4,5-Trimethoxyphenyl)-6,7-dimethoxy-2,3-naphthalenedicarboxylic acid dimethyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL25671; BDBM50075683; 6,7-Dimethoxy-1-(3,4,5-trimethoxy-phenyl)-naphthalene-2,3-dicarboxylic acid dimethyl ester
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
6-Propyl-6,9-dihydro-5H-tetrazolo[5,1-i]purin-5-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL111990; BDBM50471415
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
1,4-Dipropyl-8,9-dihydro-7H-pyrimido[2,1-f]purin-5-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL109639; BDBM50471414; 1,4-Dipropyl-1,4,5,7,8,9-hexahydropyrimido[2,1-i]purine-5-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
N-(1,3-Benzodioxol-5-ylmethyl)-6-methoxy-4-quinazolinamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL66323; N-(1,3-benzodioxol-5-ylmethyl)-6-methoxyquinazolin-4-amine; 4-{[3',4'-(Methylenedioxy)benzyl]amino}-6-methoxyquinazoline; 4-Quinazolinamine, N-(1,3-benzodioxol-5-ylmethyl)-6-methoxy-; 4-[[3',4'-(methylenedioxy)benzyl]amino]-6-methoxyquinazoline; ACMC-20ekrl; SCHEMBL678438; CTK0B1658; DTXSID20274327; BDBM50038982; HSCI1_000355; J-008706; BRD-K76263570-001-01-6; Q27195180; Benzo[1,3]dioxol-5-ylmethyl-(6-methoxy-quinazolin-4-yl)-amine; N-(Benzo[d][1,3]dioxol-5-ylmethyl)-6-methoxyquinazolin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
N-(1,3-Benzodioxol-5-ylmethyl)-6-chloro-4-quinazolinamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL66620; N-(1,3-benzodioxol-5-ylmethyl)-6-chloroquinazolin-4-amine; 4-Quinazolinamine, N-(1,3-benzodioxol-5-ylmethyl)-6-chloro-; Bio2_000664; ACMC-20ejrz; UPCMLD-DP008; BSPBio_001464; KBioGR_000184; KBioSS_000184; SCHEMBL2458882; UPCMLD-DP008:001; UPCMLD-DP008:002; CTK0E8522; KBio2_000184; KBio2_002752; KBio2_005320; KBio3_000367; KBio3_000368; 4-[[3,4-(methylenedioxy)benzyl]amino]-6-chloroquinazoline; DTXSID60425013; Bio2_000184; HMS1361J06; HMS1791J06; HMS1989J06; HMS3402J06; MBCQ, >=98% (HPLC); ZINC2568241; BDBM50038991; IDI1_033934; NCGC00161596-01; NCGC00161596-02; NCGC00161596-03; NCGC00161596-04; J-008707; 4-(3,4-methylenedioxybenzyl)amino-6-chloroquinazoline; BRD-K64746805-001-02-9; Q27164854; Benzo[1,3]dioxol-5-ylmethyl-(6-chloro-quinazolin-4-yl)-amine; N-(Benzo[d][1,3]dioxol-5-ylmethyl)-6-chloroquinazolin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
[7-Hydroxymethyl-5-(3,4,5-trimethoxy-phenyl)-naphtho[2,3-d][1,3]dioxol-6-yl]-methanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL91728; BDBM50052093; 5-(3,4,5-Trimethoxyphenyl)naphtho[2,3-d]-1,3-dioxole-6,7-dimethanol
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
1-Butyl-4-(7-ethoxy-2,3-bis-hydroxymethyl-5-methoxy-naphthalen-1-yl)-3,6-dihydro-1H-pyridin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL91042; BDBM50052085
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
2-[4-[2,3-Bis(hydroxymethyl)naphthalen-1-yl]pyridin-2-yl]-4-pyridin-3-ylphthalazin-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL553539
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
8-(4-Methyl-piperazin-1-yl)-2-(2-methyl-pyridin-4-ylmethyl)-1-oxo-4-(3,4,5-trimethoxy-phenyl)-1,2-dihydro-[2,7]naphthyridine-3-carboxylic acid methyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL77893; BDBM50130015
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
Methyl 7-[(2-methylpyridin-4-yl)methyl]-8-oxo-2-(pyrimidin-2-ylmethoxy)-5-(3,4,5-trimethoxyphenyl)-1,7-naphthyridine-6-carboxylate;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL542410
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
6,7-Dimethoxy-2-methyl-4-(3,4,5-trimethoxy-phenyl)-benzo[f]isoindole-1,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL26546; BDBM50075694; 2-Methyl-4-(3,4,5-trimethoxyphenyl)-6,7-dimethoxy-1H-benzo[f]isoindole-1,3(2H)-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
4-(6,7-Diethoxy-2,3-bis-hydroxymethyl-naphthalen-1-yl)-1-(2-methoxy-ethyl)-3,6-dihydro-1H-pyridin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL91632; BDBM50052095
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
1-Butyl-4-(6,7-diethoxy-2,3-bis-hydroxymethyl-naphthalen-1-yl)-3,6-dihydro-1H-pyridin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL327834; BDBM50052099
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
4-(2,3-Bis-hydroxymethyl-6,7-dimethoxy-naphthalen-1-yl)-1-(2-methoxy-ethyl)-3,6-dihydro-1H-pyridin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL90469; BDBM50052096
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
4-Propyl-7,8-dihydro-1H-imidazo[2,1-f]purin-5-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL111466; SCHEMBL8133177; BDBM50471417; 4-Propyl-1,4,7,8-tetrahydro-5H-imidazo[2,1-i]purin-5-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
4-Propyl-7,8,9,10-tetrahydropyrimido[2,1-f]purin-5-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL111071; BDBM50471419; 4-Propyl-1,4,5,7,8,9-hexahydropyrimido[2,1-i]purine-5-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
1-[(1-Butyl-2-oxo-1,2-dihydropyridin)-4-yl]-6,7-dimethoxynaphthalene-2,3-dimethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2115234; SCHEMBL7287261; BDBM50454211
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
N-[5-(2,3-Bis-hydroxymethyl-6,7-dimethoxy-naphthalen-1-yl)-2,3-dimethoxy-phenyl]-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL92043; BDBM50052084; 1-[3-(Acetylamino)-4,5-dimethoxyphenyl]-6,7-dimethoxynaphthalene-2,3-dimethanol
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[7] | |||
| Compound Name |
4-Propyl-8,9,10,11-tetrahydro-7H-[1,3]diazepino[2,1-f]purin-5-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL108884; BDBM50471420; 4-Propyl-1,4,7,8,9,10-hexahydro-5H-[1,3]diazepino[2,1-i]purin-5-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
3,4-Dipropyl-7,8-dihydroimidazo[2,1-f]purin-5-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL333599; SCHEMBL5964490; BDBM50471416; XT-611
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
1-(3,5-Dichlorophenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-6,7-dimethoxy-2-naphthoic acid methyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL285363; BDBM50075707
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
1-(3-Nitrophenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-6,7-dimethoxy-2-naphthoic acid methyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL287642; BDBM50075689
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
1-(3,4,5-Trimethoxyphenyl)-3-(morpholinocarbonyl)-6,7-dimethoxy-2-naphthoic acid methyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL25935; BDBM50075699
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
6-(6,7-Bis-hydroxymethyl-2,3-dimethoxy-naphthalen-1-yl)-1-methyl-3,6-dihydro-1H-pyridin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL329876; BDBM50052086
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
4-(6-Ethoxy-2,3-bis-hydroxymethyl-7-methoxy-naphthalen-1-yl)-1-(2-methoxy-ethyl)-3,6-dihydro-1H-pyridin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL330241; BDBM50052082
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
Benzo[1,3]dioxol-5-ylmethyl-(6-methylsulfanyl-quinazolin-4-yl)-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL304927; SCHEMBL7494566; BDBM50038975; 4-(3,4-Methylenedioxybenzyl)amino-6-methylthioquinazoline; N-(1,3-benzodioxol-5-ylmethyl)-6-methylsulfanylquinazolin-4-amine; N-[(1,3-Benzodioxol-5-yl)methyl]-6-(methylthio)quinazolin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
5-[2-(2-Aminoethoxy)ethoxy]-8-chlorospiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL184701; BDBM50151643
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 101000 nM
|
[10] | |||
| Compound Name |
4-[[5-(4-Chlorophenyl)-3-methyl-1,3,4-thiadiazol-2-ylidene]amino]phenol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL361512; SCHEMBL4247887; SCHEMBL4247888; BDBM50151544; 4-[5-(4-Chloro-phenyl)-3-methyl-3H-[1,3,4]thiadiazol-(2Z)-ylideneamino]-phenol
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 101000 nM
|
[11] | |||
| Compound Name |
2-[[5-(4-Chlorophenyl)-3-methyl-1,3,4-thiadiazol-2-ylidene]amino]phenol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL185531; SCHEMBL4249533; SCHEMBL4249536; BDBM50151525; 2-[5-(4-Chloro-phenyl)-3-methyl-3H-[1,3,4]thiadiazol-(2Z)-ylideneamino]-phenol
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 101000 nM
|
[11] | |||
| Compound Name |
5-(4-Chlorophenyl)-N-(3-fluorophenyl)-3-methyl-1,3,4-thiadiazol-2-imine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL365206; SCHEMBL4246678; SCHEMBL4246681; BDBM50151529; [5-(4-Chloro-phenyl)-3-methyl-3H-[1,3,4]thiadiazol-(2Z)-ylidene]-(3-fluoro-phenyl)-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 101000 nM
|
[11] | |||
| Compound Name |
3-[[5-(4-Chlorophenyl)-3-methyl-1,3,4-thiadiazol-2-ylidene]amino]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL363709; SCHEMBL4251363; SCHEMBL4251364; BDBM50151567; 3-[5-(4-Chloro-phenyl)-3-methyl-3H-[1,3,4]thiadiazol-(2Z)-ylideneamino]-benzonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 101000 nM
|
[11] | |||
| Compound Name |
8-Chloro-5-[2-hydroxy-3-(methylamino)propoxy]spiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL364200; BDBM50151633
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 101000 nM
|
[10] | |||
| Compound Name |
8-Chloro-5-[3-(dimethylamino)-2-hydroxypropoxy]spiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL184013; BDBM50151632
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 101000 nM
|
[10] | |||
| Compound Name |
8-Chloro-5-[3-(dimethylamino)propoxy]spiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL185108; BDBM50151637
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 101000 nM
|
[10] | |||
| Compound Name |
5-(4-Imidazol-1-yl-phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-pyridine-3-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL61692; BDBM50018627
Click to Show/Hide
|
||||
| Activity |
IC50 = 130000 nM
|
[15] | |||
| Compound Name |
4,5-Dihydro-6-[4-(4,5,6,7-tetrahydro-1H-benzimidazol-1-yl)phenyl]-3(2H)-pyridazinone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL30623; SCHEMBL7289586; BDBM50018624; 3-[4-(4,5,6,7-tetrahydrobenzimidazol-1-yl)phenyl]-4,5-dihydro-1H-pyridazin-6-one; 6-[4-(4,5,6,7-Tetrahydro-benzoimidazol-1-yl)-phenyl]-4,5-dihydro-2H-pyridazin-3-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 140000 nM
|
[5] | |||
| Compound Name |
1-Butyl-3-propyl-5,7-dihydro-4H-purine-2,6-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL110304; XT-44; BDBM50471412
Click to Show/Hide
|
||||
| Activity |
IC50 = 149000 nM
|
[12] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 44 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Inamrinone Lactate
Click to Show/Hide
|
Approved | Compound Info | ||
| Synonyms |
Amrinone; inamrinone; 60719-84-8; Wincoram; Inocor; Cordemcura; Cartonic; 5-Amino-[3,4'-bipyridin]-6(1H)-one; Amrinonum [INN-Latin]; Amrinonum; Amrinona; Amrinona [INN-Spanish]; 3-Amino-5-(4-pyridinyl)-2(1H)-pyridinone; Win-40680; Amcoral; 5-Amino-(3,4'-bipyridin)-6(1H)-one; WIN 40680; AWD 08-250; 3-amino-5-pyridin-4-yl-1H-pyridin-2-one; UNII-JUT23379TN; CCRIS 3794; Amrinone lactate; MLS000069829; EINECS 262-390-0; 5-amino-3,4'-bipyridin-6(1H)-one; BRN 0744819; 5-Amino(3,4'-bipyridin)-6(1H)-one; SMR000058850; CHEMBL12856; JUT23379TN; Amrinone Lactate
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[12] | |||
| Compound Name |
Cilostazol
Click to Show/Hide
|
Approved | Compound Info | ||
| Synonyms |
cilostazol; 73963-72-1; Pletal; Cilostazole; Pletaal; Cilostazolum; OPC-13013; Cilostazolum [INN-Latin]; OPC-21; OPC 13013; OPC 21; UNII-N7Z035406B; CHEBI:31401; C20H27N5O2; 6-(4-(1-Cyclohexyl-1H-tetrazol-5-yl)butoxy)-3,4-dihydro-2(1H)-quinolinone; BRN 3632107; 6-[4-(1-cyclohexyltetrazol-5-yl)butoxy]-3,4-dihydro-1H-quinolin-2-one; 6-(4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy)-3,4-dihydroquinolin-2(1H)-one; 3,4-Dihydro-6-(4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy)-2(1H)-quinolinone; MLS000028470; Cilostazole; Otsuka brand of cilostazol; C 0737; CL23867; Cilostazol [INN:JAN]; Pleta (TN); Pletal (TN); Pletal, Cilostazol; Cilostazol (JP15/USAN/INN); 6-(4-(1-Cyclohexyl-1H-tetrazol-5-yl)butoxy)-3,4-dihydrocarbostyril; 6-(4-(1-Cyclohexyl-1H-tetrazol-5-yl)butoxyl)-3,4-dihydrocarobostyril; 6-[4-(1-Cyclohexyl-1H-tetrazol-5-yl)-butoxy]-3,4-dihydro-2(1H)-quinolinone; 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydroquinolin-2(1H)-one
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[16] | |||
| Compound Name |
Enoximone
Click to Show/Hide
|
Approved | Compound Info | ||
| Synonyms |
ENOXIMONE; Perfan; 77671-31-9; Fenoximone; Enoximonum [Latin]; MDL-17043; Enoximona [Spanish]; MDL 17,043; UNII-C7Z4ITI7L7; MDL-17,043; RMI-17043; 4-methyl-5-(4-methylsulfanylbenzoyl)-1,3-dihydroimidazol-2-one; C7Z4ITI7L7; 4-Methyl-5-(p-(methylthio)benzoyl)-4-imidazolin-2-one; CHEMBL249856; 2H-Imidazol-2-one, 1,3-dihydro-4-methyl-5-(4-(methylthio)benzoyl)-; NCGC00015400-02; Enoximonum; Enoximona; 1,3-Dihydro-4-methyl-5-[4-methylthiobenzoyl]-2H-imidazol-2-one; DSSTox_RID_80702; DSSTox_CID_25147; DSSTox_GSID_45147; Perfane; Enoximona; E 1279; Perfan (TN); Enoximone (USAN/INN); Enoximone [USAN:BAN:INN]; 1,3-Dihydro-4-methyl-5-(4-methylthiobenzoyl)-2H-imidazol-2-one; FENOXIMONE
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[16] | |||
| Compound Name |
PMID28870136-Compound-48
Click to Show/Hide
|
Patented | Compound Info | ||
| Activity |
IC50 = 320000 nM
|
[16] | |||
| Compound Name |
Ro 20-1724
Click to Show/Hide
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Terminated | Compound Info | ||
| Synonyms |
4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; RO 20-1724; 29925-17-5; 4-(3-Butoxy-4-methoxybenzyl)imidazolidin-2-one; ro-20-1724; Ro 201724; CHEMBL18701; 4-[(3-butoxy-4-methoxyphenyl)methyl]imidazolidin-2-one; 2-Imidazolidinone, 4-((3-butoxy-4-methoxyphenyl)methyl)-; RO-201724; 2-Imidazolidinone, 4-((3-butoxy-4-methoxyphenyl)methyl)-, (+-)-; 4-(3-butoxy-4-methoxy-benzyl)imidazolidin-2-one; 34185-37-0; 4-(3-butoxy-4-methoxyphenyl)methyl-2-imidazolidone; SR-01000075647; keratan sulfate I; Keratan sulphate I; Naphthoquinone analogs
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||||
| Activity |
IC50 = 250000 nM
|
[16] | |||
| Compound Name |
Benzamide,n-(2-chlorophenyl)-3-(cyclopentyloxy)-4-methoxy-
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL289190; SCHEMBL7334642; BDBM50041828; ZINC13736941; n-(2-chlorophenyl)-3-cyclopentyloxy-4-methoxybenzamide; N-(2-Chloro-phenyl)-3-cyclopentyloxy-4-methoxy-benzamide; N-(2-Chlorophenyl)-3-(cyclopentyloxy)-4-methoxybenzamide
Click to Show/Hide
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||||
| Activity |
IC50 > 200000 nM
|
[17] | |||
| Compound Name |
3-Cyclopentyloxy-N-(2,5-dichloro-phenyl)-4-methoxy-benzamide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL44673; SCHEMBL7340498; BDBM50041823; 3-cyclopentyloxy-N-(2,5-dichlorophenyl)-4-methoxybenzamide; N-(2,5-Dichlorophenyl)-3-(cyclopentyloxy)-4-methoxybenzamide
Click to Show/Hide
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||||
| Activity |
IC50 > 200000 nM
|
[17] | |||
| Compound Name |
3-Cyclopentyloxy-N-(2-hydroxy-phenyl)-4-methoxy-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL416466; SCHEMBL7335104; BDBM50041868; 3-cyclopentyloxy-N-(2-hydroxyphenyl)-4-methoxybenzamide; N-(2-Hydroxyphenyl)-3-(cyclopentyloxy)-4-methoxybenzamide
Click to Show/Hide
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||||
| Activity |
IC50 > 200000 nM
|
[17] | |||
| Compound Name |
3-Cyclopentyloxy-N-(2,3-dichloro-phenyl)-4-methoxy-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL44967; BDBM50041852; N-(2,3-Dichlorophenyl)-3-(cyclopentyloxy)-4-methoxybenzamide
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||||
| Activity |
IC50 > 200000 nM
|
[17] | |||
| Compound Name |
(2R,3S)-3-(6-Amino-9H-purin-9-yl)nonan-2-ol
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL50378; (2R,3S)-EHNA; (2R,3S)-3-(6-aminopurin-9-yl)nonan-2-ol; (2R,3S)-3-(adenin-9-yl)-2-nonanol; (2R,3S)-9-(2-hydroxy-3-nonyl)adenine; erythro-9-(2-hydroxy-3-nonyl)adenine; (R,S)-6-amino-beta-hexyl-alpha-methyl-9H-purine-9-ethanol; EHNA.HCl; HWC 52; eh-na; Tocris-1261; (-)-erythro-9-(2-hydroxy-3-nonyl)adenine; Lopac0_000504; BSPBio_001061; KBioGR_000401; KBioSS_000401; SCHEMBL1742893; DTXSID6043880; BCBcMAP01_000066; CTK2H9386; KBio2_000401; KBio2_002969; KBio2_005537; KBio3_000761; KBio3_000762; Bio1_000430; Bio1_000919; Bio1_001408; Bio2_000361; Bio2_000841; HMS1792E03; HMS1990E03; HMS3403E03; ZINC1614354; (R-(R*,S*))-6-Amino-beta-hexyl-alpha-methyl-9H-purine-9-ethanol; BDBM50034908; CCG-36414; 9H-Purine-9-ethanol, 6-amino-beta-hexyl-alpha-methyl-, (R*,S*)-(+-)-; 9H-Purine-9-ethanol, 6-amino-beta-hexyl-alpha-methyl-, (R-(R*,S*))-; SDCCGSBI-0050488.P002; 3-(6-Amino-purin-9-yl)-nonan-2-ol; IDI1_002116; SMP2_000310; NCGC00025087-01; NCGC00025087-02; NCGC00025087-03; NCGC00025087-04; NCGC00025087-05; NCGC00025087-06; NCGC00025087-08; (EHNA)3-(6-Amino-purin-9-yl)-nonan-2-ol; 3-(6-Amino-purin-9-yl)-nonan-2-ol(EHNA); (2R,3S)-3-(6-Amino-purin-9-yl)-nonan-2-ol; (2R,3S)-3-(6-Amino-9H-purine-9-yl)2-nonanol; (2R,3S)-3-((R)-6-Amino-purin-9-yl)-nonan-2-ol; BRD-K27450477-001-03-9; (2R,3S)-rel-3-(6-Amino-9H-purin-9-yl)nonan-2-ol
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||||
| Activity |
Ki > 200000 nM
|
[18] | |||
| Compound Name |
3-Cyclopentyloxy-4-methoxy-N-(2-methylsulfanylphenyl)benzamide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL47957; Benzamide, 3-(cyclopentyloxy)-4-methoxy-N-[2-(methylthio)phenyl]-; ACMC-20n3iw; SCHEMBL73091; CTK0E9814; DTXSID10438390; BDBM50041841; N-[2-(Methylthio)phenyl]-3-(cyclopentyloxy)-4-methoxybenzamide; 3-Cyclopentyloxy-4-methoxy-N-(2-methylsulfanyl-phenyl)-benzamide
Click to Show/Hide
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||||
| Activity |
IC50 > 200000 nM
|
[17] | |||
| Compound Name |
3-Cyclopentyloxy-4-methoxy-N-p-tolyl-benzamide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL47954; BDBM50041860; N-(4-Methylphenyl)-3-(cyclopentyloxy)-4-methoxybenzamide
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||||
| Activity |
IC50 > 200000 nM
|
[17] | |||
| Compound Name |
6-(4-Benzoimidazol-1-yl-phenyl)-4,5-dihydro-2H-pyridazin-3-one
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL30402; SCHEMBL7280920; BDBM50018618; 3-[4-(benzimidazol-1-yl)phenyl]-4,5-dihydro-1H-pyridazin-6-one; 4,5-dihydro-6-[4-(1H-benzimidazol-1-yl)phenyl]-3(2H)-pyridazinone
Click to Show/Hide
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||||
| Activity |
IC50 = 220000 nM
|
[5] | |||
| Compound Name |
3-Cyclopentyloxy-N-(2,6-dimethyl-phenyl)-4-methoxy-benzamide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL295669; SCHEMBL7334292; BDBM50041826; 3-cyclopentyloxy-N-(2,6-dimethylphenyl)-4-methoxybenzamide; N-(2,6-Dimethylphenyl)-3-(cyclopentyloxy)-4-methoxybenzamide
Click to Show/Hide
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||||
| Activity |
IC50 = 250000 nM
|
[17] | |||
| Compound Name |
1H-Imidazo(4,5-b)pyridine, 2-(2,4-dimethoxyphenyl)-
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL43406; 2-(2,4-Dimethoxyphenyl)-1H-imidazo(4,5-b)pyridine; 2-(2,4-dimethoxyphenyl)-1H-imidazo[4,5-b]pyridine; 2-(2,4-Dimethoxy-phenyl)-3H-imidazo[4,5-b]pyridine; AR-L 57BS; 2-(2,4-dimethoxyphenyl)-3H-imidazo[4,5-b]pyridine; SCHEMBL6040494; SCHEMBL11770981; AR-L-57; DTXSID50228055; ZINC5115747; BDBM50020868; AKOS011056149; MCULE-1037524258; AM20061499; 2-(2,4-Dimethoxy-phenyl)-1H-imidazo[4,5-b]pyridine; 2-(2,4-dimethoxy-phenyl)-3H-imidazo[5,4-b]pyridine
Click to Show/Hide
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||||
| Activity |
IC50 = 265000 nM
|
[16] | |||
| Compound Name |
6-[4-(1H-Imidazol-2-yl)-phenyl]-2H-pyridazin-3-one
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL58728; BDBM50018620; ZINC29569665
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||||
| Activity |
IC50 = 330000 nM
|
[15] | |||
| Compound Name |
4-(4-Imidazol-1-yl-phenyl)-4a,5,6,7,8,8a-hexahydro-2H-phthalazin-1-one
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL30358; BDBM50018612
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||||
| Activity |
IC50 = 380000 nM
|
[5] | |||
| Compound Name |
3-Cyclopentyloxy-4-methoxy-N-(2-nitrophenyl)benzamide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL45687; SCHEMBL7337371; BDBM50041851; 3-Cyclopentyloxy-4-methoxy-N-(2-nitro-phenyl)-benzamide; N-(2-Nitrophenyl)-3-(cyclopentyloxy)-4-methoxybenzamide
Click to Show/Hide
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||||
| Activity |
IC50 = 400000 nM
|
[17] | |||
| Compound Name |
4-Acetyl-1-methyl-7-(4-pyridyl)-5,6,7,8-tetrahydro-3(2H)-isoquinolinone
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
MS-857; CHEMBL116992; 4-Acetyl-1-methyl-7-pyridin-4-yl-5,6,7,8-tetrahydro-2H-isoquinolin-3-one; 3(2H)-Isoquinolinone,4-acetyl-5,6,7,8-tetrahydro-1-methyl-7-(4-pyridinyl)-; BRN 6416236; ACMC-20maw3; 5,6,7,8-Tetrahydro-4-acetyl-1-methyl-7-(4-pyridinyl)-3(2H)-isoquinolinone; SCHEMBL2456049; CTK4A5048; DTXSID00910251; BDBM50228048; 3(2H)-Isoquinoline, 4-acetyl-5,6,7,8-tetrahydro-1-methyl-7-(4-pyridinyl)-; 3(2H)-Isoquinolinone, 5,6,7,8-tetrahydro-4-acetyl-1-methyl-7-(4-pyridinyl)-
Click to Show/Hide
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||||
| Activity |
IC50 = 409000 nM
|
[2] | |||
| Compound Name |
4-Amino-6-(4-imidazol-1-ylphenyl)-2H-pyridazin-3-one
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL448467; SCHEMBL10668965; BDBM50018611; AKOS015906124; 5-amino-3-(4-imidazol-1-ylphenyl)-1H-pyridazin-6-one; 4-Amino-6-(4-imidazol-1-yl-phenyl)-2H-pyridazin-3-one; 4-amino-6-[4-(1H-imidazol-1-yl)-phenyl]-2H-pyridazin-3-one
Click to Show/Hide
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||||
| Activity |
IC50 > 500000 nM
|
[5] | |||
| Compound Name |
4,5-Dihydro-6-[4-(2-methyl-1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinone
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL30368; SCHEMBL7280962; BDBM50018619; 3-[4-(2-methylimidazol-1-yl)phenyl]-4,5-dihydro-1H-pyridazin-6-one; 6-[4-(2-Methyl-imidazol-1-yl)-phenyl]-4,5-dihydro-2H-pyridazin-3-one
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||||
| Activity |
IC50 = 530000 nM
|
[5] | |||
| Compound Name |
6-(4-Imidazol-1-yl-phenyl)-2H-pyridazin-3-one
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL287398; SCHEMBL7280366; BDBM50018617; ZINC26420394; AKOS005207362; 3-(4-imidazol-1-ylphenyl)-1H-pyridazin-6-one; 6-[4-(1{H}-imidazol-1-yl)phenyl]pyridazin-3-ol; 6-[4-(1H-Imidazol-1-yl)phenyl]pyridazin-3(2H)-one; F1967-0319
Click to Show/Hide
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||||
| Activity |
IC50 = 580000 nM
|
[15] | |||
| Compound Name |
6-(4-(1H-Imidazol-1-yl)phenyl)-5-methylpyridazin-3(2H)-one
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL31105; 6-[4-(1H-Imidazol-1-yl)phenyl]-5-methylpyridazin-3(2H)-one; SCHEMBL7290528; CTK2I3158; DTXSID10555899; BDBM50018613; ZINC29213003; 3-(4-imidazol-1-ylphenyl)-4-methyl-1H-pyridazin-6-one; 6-(4-Imidazol-1-yl-phenyl)-5-methyl-2H-pyridazin-3-one; 3(2H)-Pyridazinone, 6-[4-(1H-imidazol-1-yl)phenyl]-5-methyl-
Click to Show/Hide
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||||
| Activity |
IC50 = 660000 nM
|
[15] | |||
| Compound Name |
N-(6-Methyl-8-propyl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)acetamide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
Ici 58301; ICI-58301; CHEMBL358641; DTXSID40177846; 3-Acetamido-6-methyl-8-n-propyl-s-triazolo(4,3alpha)pyrazine; BDBM50225505; Acetamide, N-(6-methyl-8-propyl-1,2,4-triazolo(4,3-a)pyrazin-3-yl)-
Click to Show/Hide
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||||
| Activity |
Ki = 717000 nM
|
[16] | |||
| Compound Name |
6-(3-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-pyridazin-3-one
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL30367; SCHEMBL7278112; BDBM50018622; 3-(3-imidazol-1-ylphenyl)-4,5-dihydro-1H-pyridazin-6-one
Click to Show/Hide
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||||
| Activity |
IC50 = 930000 nM
|
[15] | |||
| Compound Name |
4,5-Dihydro-6-[4-(4-hydroxymethyl-1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinone
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL286502; SCHEMBL7277863; BDBM50018623; 3-[4-[4-(hydroxymethyl)imidazol-1-yl]phenyl]-4,5-dihydro-1H-pyridazin-6-one; 6-[4-(4-Hydroxymethyl-imidazol-1-yl)-phenyl]-4,5-dihydro-2H-pyridazin-3-one
Click to Show/Hide
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| Activity |
IC50 > 1000000 nM
|
[5] | |||
| Compound Name |
Sulmazole
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Investigative | Compound Info | ||
| Synonyms |
sulmazol; Sulmazolum; 2-[2-methoxy-4-(methylsulfinyl)phenyl]-1H-imidazo[4,5-b]pyridine; Vardax; CHEMBL286020; NCGC00016924-02; 2-(2-Methoxy-4-(methylsulfinyl)phenyl)-1H-imidazo(4,5-b)pyridine; Sulmazole [INN]; Sulmazol [INN-Spanish]; Sulmazolum [INN-Latin]; 2-(2-Methoxy-4-(methylsulfinyl)phenyl)-3H-imidazo(4,5-b)pyridine; 2-(2-Methoxy-4-(methylsulfinyl)phenyl)-3H-imidazo[4,5-b]pyridine; 2-(2-Methoxy-4-[methylsulfinyl]phenyl)-1H-imidazo(4,5-b)pyridine; 2-[2-methoxy-4-(methylsulfinyl)phenyl]-3H-imidazo[4,5-b]pyridine; AR-L 115BS; AR-L 115-BS; SR-01000841215; EINECS 277-406-1; BRN 0818370; 2-(2-methoxy-4-(methylsulfinyl)phenyl)-1H-imidazo[4,5-b]pyridine; Prestwick_1012; Spectrum_001155; Prestwick0_000641; Prestwick1_000641; Prestwick2_000641; Prestwick3_000641; Spectrum3_000733; Spectrum4_001246; Spectrum5_002074; 1H-Imidazo(4,5-b)pyridine, 2-(2-methoxy-4-(methylsulfinyl)phenyl)-; DSSTox_CID_20617; DSSTox_RID_79513; DSSTox_GSID_40617; BSPBio_000641; BSPBio_002286; KBioGR_001772; KBioSS_001635; MLS002153927; DivK1c_000276; SCHEMBL187165; SPECTRUM1501159; SPBio_002562; BPBio1_000707; DTXSID1040617; AR-L-115-BS; CTK5D7914; CTK9A2962; HMS500N18; KBio1_000276; KBio2_001635; KBio2_004203; KBio2_006771; KBio3_001506; NINDS_000276; HMS1570A03; HMS2097A03; HMS2230O09; HMS3371L17; HMS3714A03; Pharmakon1600-01501159; Tox21_110685; BDBM50000056; BDBM50225309; CCG-38446; NSC757867; CCG-220641; NSC-757867; IDI1_000276; NCGC00016924-01; NCGC00095999-01; DA-03205; SMR001233271; SBI-0051668.P002; AB00052230; FT-0748740; C13749; SR-01000841215-2; SR-01000841215-3; BRD-A22081593-001-04-6; BRD-A22081593-001-06-1; Q27116354; 2-methoxy-4-(methylsulfinyl)-phenylimidazo[4,5-b]pyridine; 2-(2-methoxy-4-methylsulfinyl-phenyl)-1H-imidazo[4,5-b]pyridine; 2-(4-Methanesulfinyl-2-methoxy-phenyl)-1H-imidazo[4,5-b]pyridine; 2-(4-Methanesulfinyl-2-methoxy-phenyl)-3H-imidazo[4,5-b]pyridine; 2-Methyl-6-oxo-1,6-dihydro-[3,4'']bipyridinyl-5-carbonitrile; 3H-Imidazo[4,5-b]pyridine,2-[2-methoxy-4-(methylsulfinyl)phenyl]-; (sulmazole)2-(4-Methanesulfinyl-2-methoxy-phenyl)-3H-imidazo[4,5-b]pyridine; 2-(4-Methanesulfinyl-2-methoxy-phenyl)-1H-imidazo[4,5-b]pyridine (sulmazole); 2-(4-Methanesulfinyl-2-methoxy-phenyl)-1H-imidazo[4,5-b]pyridine(sulmazole)
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| Activity |
IC50 > 1000000 nM
|
[16] | |||
| Compound Name |
3-(Cyclopentyloxy)-N-(2-fluorophenyl)-4-methoxybenzamide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL47683; SCHEMBL7336803; BDBM50041862; 3-cyclopentyloxy-N-(2-fluorophenyl)-4-methoxybenzamide; 3-Cyclopentyloxy-N-(2-fluoro-phenyl)-4-methoxy-benzamide; N-(2-Fluorophenyl)-3-(cyclopentyloxy)-4-methoxybenzamide
Click to Show/Hide
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| Activity |
IC50 > 1000000 nM
|
[17] | |||
| Compound Name |
N-(2-Hydroxybutyl)-5-[(2-oxo-3,4-dihydro-1H-quinolin-6-yl)oxy]-N-phenylpentanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL347523; BDBM50225503
Click to Show/Hide
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| Activity |
IC50 > 1000000 nM
|
[16] | |||
| Compound Name |
3(2H)-Pyridazinone, 5-ethyl-4,5-dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL30362; ACMC-20l9l5; SCHEMBL11206290; CTK3B1886; DTXSID00530655; BDBM50018614; 4-ethyl-3-(4-imidazol-1-ylphenyl)-4,5-dihydro-1H-pyridazin-6-one; 3-[4-(1H-Imidazole-1-yl)phenyl]-4-ethyl-4,5-dihydropyridazine-6(1H)-one; 5-Ethyl-6-(4-imidazol-1-yl-phenyl)-4,5-dihydro-2H-pyridazin-3-one; 5-Ethyl-6-[4-(1H-imidazol-1-yl)phenyl]-4,5-dihydropyridazin-3(2H)-one
Click to Show/Hide
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| Activity |
IC50 > 1000000 nM
|
[5] | |||
| Compound Name |
3-(Cyclopentyloxy)-N-(2,6-dichlorophenyl)-4-methoxybenzamide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL45834; Benzamide, 3-(cyclopentyloxy)-N-(2,6-dichlorophenyl)-4-methoxy-; ACMC-20n3iv; SCHEMBL7338641; CTK0E9815; DTXSID10437343; BDBM50041838; 3-cyclopentyloxy-N-(2,6-dichlorophenyl)-4-methoxybenzamide; 3-Cyclopentyloxy-N-(2,6-dichloro-phenyl)-4-methoxy-benzamide; N-(2,6-Dichlorophenyl)-3-(cyclopentyloxy)-4-methoxybenzamide
Click to Show/Hide
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| Activity |
IC50 > 1000000 nM
|
[17] | |||
| Compound Name |
3-Cyclopentyloxy-N-(2,6-dibromo-phenyl)-4-methoxy-benzamide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL46044; SCHEMBL7332380; BDBM50041833; 3-cyclopentyloxy-N-(2,6-dibromophenyl)-4-methoxybenzamide; N-(2,6-Dibromophenyl)-3-(cyclopentyloxy)-4-methoxybenzamide
Click to Show/Hide
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| Activity |
IC50 > 1000000 nM
|
[17] | |||
| Compound Name |
N-(2-Chloro-6-methyl-phenyl)-3-cyclopentyloxy-4-methoxy-benzamide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL294949; benzamide,n-(2-chloro-6-methylphenyl)-3-(cyclopentyloxy)-4-methoxy-; SCHEMBL7334555; ZINC605606; BDBM50041854; n-(2-chloro-6-methylphenyl)-3-cyclopentyloxy-4-methoxybenzamide; N-(2-Methyl-6-chlorophenyl)-3-(cyclopentyloxy)-4-methoxybenzamide
Click to Show/Hide
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| Activity |
IC50 > 1000000 nM
|
[17] | |||
| Compound Name |
N-(4-Chloro-phenyl)-3-cyclopentyloxy-4-methoxy-benzamide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL45822; BDBM50041857; N-(4-Chlorophenyl)-3-(cyclopentyloxy)-4-methoxybenzamide
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| Activity |
IC50 > 1000000 nM
|
[17] | |||
| Compound Name |
3-(Cyclopentyloxy)-N-(2,6-difluorophenyl)-4-methoxybenzamide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL47113; Benzamide, 3-(cyclopentyloxy)-N-(2,6-difluorophenyl)-4-methoxy-; ACMC-20n3iu; SCHEMBL7335862; CTK0E9816; DTXSID20430906; BDBM50041844; 3-cyclopentyloxy-N-(2,6-difluorophenyl)-4-methoxybenzamide; N-(2,6-difiuorophenyl)-3-cyclopentyloxy-4-methoxybenzamide; N-(2,6-difluorophenyl)-3-cyclopentyloxy-4-methoxybenzamide; 3-Cyclopentyloxy-N-(2,6-difluoro-phenyl)-4-methoxy-benzamide; N-(2,6-Difluorophenyl)-3-(cyclopentyloxy)-4-methoxybenzamide
Click to Show/Hide
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| Activity |
IC50 > 1000000 nM
|
[17] | |||
| Compound Name |
6-(4-Imidazol-1-yl-phenyl)-2-methyl-4,5-dihydro-2H-pyridazin-3-one
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL31112; SCHEMBL7280036; BDBM50018616; 6-(4-imidazol-1-ylphenyl)-2-methyl-4,5-dihydropyridazin-3-one; 4,5-dihydro-2-methyl-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinone
Click to Show/Hide
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| Activity |
IC50 > 1000000 nM
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[5] | |||
| Compound Name |
3-Cyclopentyloxy-N-(4-fluoro-phenyl)-4-methoxy-benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL296646; BDBM50041871; N-(4-Fluorophenyl)-3-(cyclopentyloxy)-4-methoxybenzamide
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||||
| Activity |
IC50 > 1000000 nM
|
[17] | |||
| Compound Name |
Benzamide,n-(2-bromophenyl)-3-(cyclopentyloxy)-4-methoxy-
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL296700; SCHEMBL7334985; BDBM50041845; ZINC13736951; n-(2-bromophenyl)-3-cyclopentyloxy-4-methoxybenzamide; N-(2-Bromo-phenyl)-3-cyclopentyloxy-4-methoxy-benzamide; N-(2-Bromophenyl)-3-(cyclopentyloxy)-4-methoxybenzamide
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||||
| Activity |
IC50 > 1000000 nM
|
[17] | |||
| Compound Name |
3-Cyclopentyloxy-4-methoxy-N-phenyl-benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL46321; SCHEMBL7340175; BDBM50041829; 3-cyclopentyloxy-4-methoxy-N-phenylbenzamide; N-Phenyl-3-(cyclopentyloxy)-4-methoxybenzamide
Click to Show/Hide
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||||
| Activity |
IC50 > 1000000 nM
|
[17] | |||
| Compound Name |
Imazodan
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Investigative | Compound Info | ||
| Synonyms |
6-(4-(1H-imidazol-1-yl)phenyl)-4,5-dihydropyridazin-3(2H)-one; UNII-6PVQ5VQW24; CI 914; Cl 914; 3-(4-imidazol-1-ylphenyl)-4,5-dihydro-1H-pyridazin-6-one; 6PVQ5VQW24; CHEMBL12831; MFCD00867109; NCGC00015547-02; 4,5-Dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinone; 3(2H)-Pyridazinone, 4,5-dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-; Imazodan [INN]; Imazodanum [Latin]; Imazodanum; 3(2H)-Pyridazinone, 4,5-dihydro-6-(4-(1H-imidazol-1-yl)phenyl)-; Lopac-I-0782; DSSTox_CID_25160; DSSTox_RID_80710; DSSTox_GSID_45160; Lopac0_000639; MLS000862182; SCHEMBL148436; ZINC1553; Imazodan, >=99% (HPLC); DTXSID1045160; CTK8G0276; HMS2233L24; HMS3261P20; HMS3369I22; KS-000001DA; Tox21_110171; Tox21_500639; BDBM50000315; AKOS027327583; CCG-204726; LP00639; QC-1573; SDCCGSBI-0050619.P002; NCGC00015547-01; NCGC00015547-03; NCGC00015547-04; NCGC00015547-05; NCGC00094006-01; NCGC00094006-02; NCGC00261324-01; AK326183; DS-11856; SMR000326945; DB-056777; EU-0100639; FT-0630925; I 0782; 4,5-dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-; SR-01000075931; SR-01000075931-1; Q27265291; 6-(4-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-pyridazin-3-one; (CI-914)6-(4-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-pyridazin-3-one; 6-(4-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-pyridazin-3-one(CI-914); 6-(4-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-pyridazin-3-one(Imazodan)
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||||
| Activity |
IC50 > 1000000 nM
|
[16] | |||
| Compound Name |
3-Cyclopentyloxy-4-methoxy-N-(2-trifluoromethyl-phenyl)-benzamide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL44109; SCHEMBL7335856; 3-cyclopentyloxy-4-methoxy-N-[2-(trifluoromethyl)phenyl]benzamide; BDBM50041863; 3-(cyclopentyloxy)-4-methoxy-N-(2-(trifluoromethyl)phenyl)benzamide; N-[2-(Trifluoromethyl)phenyl]-3-(cyclopentyloxy)-4-methoxybenzamide
Click to Show/Hide
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||||
| Activity |
IC50 > 1000000 nM
|
[17] | |||
| Compound Name |
N-(2-Chloro-6-fluoro-phenyl)-3-cyclopentyloxy-4-methoxy-benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL45128; benzamide,n-(2-chloro-6-fluorophenyl)-3-(cyclopentyloxy)-4-methoxy-; SCHEMBL7334330; ZINC605604; BDBM50041855; N-(2-Chloro-6-fluorophenyl)-3-(cyclopentyloxy)-4-methoxybenzamide; n-(2-chloro-6-fluorophenyl)-3-cyclopentyloxy-4-methoxybenzamide
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||||
| Activity |
IC50 > 1000000 nM
|
[17] | |||
| Compound Name |
3-Cyclopentyloxy-4-methoxy-N-o-tolyl-benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL431146; BDBM50041858; N-(2-Methylphenyl)-3-(cyclopentyloxy)-4-methoxybenzamide
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||||
| Activity |
IC50 > 1000000 nM
|
[17] | |||
| Compound Name |
6-(4-Imidazol-1-yl-phenyl)-4-methyl-4,5-dihydro-2H-pyridazin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL31762; SCHEMBL11099239; BDBM50018621; 3-(4-imidazol-1-ylphenyl)-5-methyl-4,5-dihydro-1H-pyridazin-6-one
Click to Show/Hide
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||||
| Activity |
IC50 > 1000000 nM
|
[5] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Cyclic GMP phosphodiesterase inhibitors. 1. The discovery of a novel potent inhibitor, 4-((3,4-(methylenedioxy)benzyl)amino)-6,7,8-trimethoxyquinazoline. J Med Chem. 1993 Nov 26;36(24):3765-70. | ||||
| REF 2 | Cardiotonic agents. 1-Methyl-7-(4-pyridyl)-5,6,7,8-tetrahydro-3 (2H)-isoquinolinones and related compounds. Synthesis and activity. J Med Chem. 1989 Feb;32(2):351-7. | ||||
| REF 3 | Novel, potent, and selective phosphodiesterase-4 inhibitors as antiasthmatic agents: synthesis and biological activities of a series of 1-pyridylnaphthalene derivatives. J Med Chem. 1999 Mar 25;42(6):1088-99. | ||||
| REF 4 | Imidazotriazinone inhibitors of the Ca2+-calmodulin sensitive phosphodiesterase (PDE I). Bioorg Med Chem Lett. 1997 Jan 7;7(1):89-94. | ||||
| REF 5 | Cardiotonic agents. 7. Inhibition of separated forms of cyclic nucleotide phosphodiesterase from guinea pig cardiac muscle by 4,5-dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones and related compounds. Structure-activity relationships and correlation with in vivo positive inotropic activity. J Med Chem. 1987 Nov;30(11):1955-62. | ||||
| REF 6 | Inhibition of cyclic nucleotide phosphodiesterases from pig coronary artery by benzo-separated analogues of 3-isobutyl-1-methylxanthine. J Med Chem. 1986 Jun;29(6):972-8. | ||||
| REF 7 | Novel selective PDE IV inhibitors as antiasthmatic agents. Synthesis and biological activities of a series of 1-aryl-2,3-bis(hydroxymethyl)naphthalene lignans. J Med Chem. 1996 Jul 5;39(14):2696-704. | ||||
| REF 8 | New substituted triaza-benzo[cd]azulen-9-ones as promising phosphodiesterase-4 inhibitors. Bioorg Med Chem Lett. 2004 Jun 21;14(12):3303-6. | ||||
| REF 9 | 1-Arylnaphthalene lignan: a novel scaffold for type 5 phosphodiesterase inhibitor. J Med Chem. 1999 Apr 8;42(7):1293-305. | ||||
| REF 10 | Spiroquinazolinones as novel, potent, and selective PDE7 inhibitors. Part 2: Optimization of 5,8-disubstituted derivatives. Bioorg Med Chem Lett. 2004 Sep 20;14(18):4627-31. | ||||
| REF 11 | Discovery of thiadiazoles as a novel structural class of potent and selective PDE7 inhibitors. Part 1: design, synthesis and structure-activity relationship studies. Bioorg Med Chem Lett. 2004 Sep 20;14(18):4607-13. | ||||
| REF 12 | Selective inhibitors of cyclic AMP-specific phosphodiesterase: heterocycle-condensed purines. J Med Chem. 1997 Sep 26;40(20):3248-53. | ||||
| REF 13 | 1,7- and 2,7-naphthyridine derivatives as potent and highly specific PDE5 inhibitors. Bioorg Med Chem Lett. 2003 Jul 21;13(14):2341-5. | ||||
| REF 14 | Cyclic GMP phosphodiesterase inhibitors. 2. Requirement of 6-substitution of quinazoline derivatives for potent and selective inhibitory activity. J Med Chem. 1994 Jun 24;37(13):2106-11. | ||||
| REF 15 | Cardiotonic agents. 8. Selective inhibitors of adenosine 3',5'-cyclic phosphate phosphodiesterase III. Elaboration of a five-point model for positive inotropic activity. J Med Chem. 1987 Nov;30(11):1963-72. | ||||
| REF 16 | A new generation of phosphodiesterase inhibitors: multiple molecular forms of phosphodiesterase and the potential for drug selectivity. J Med Chem. 1985 May;28(5):537-45. | ||||
| REF 17 | Selective type IV phosphodiesterase inhibitors as antiasthmatic agents. The syntheses and biological activities of 3-(cyclopentyloxy)-4-methoxybenzamides and analogues. J Med Chem. 1994 May 27;37(11):1696-703. | ||||
| REF 18 | 9-Benzyladenines: potent and selective cAMP phosphodiesterase inhibitors. J Med Chem. 1997 Jun 6;40(12):1768-70. | ||||
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