Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T59082 | Target Info | |||
| Target Name | Membrane-associated lectin type-C (CD209) | ||||
| Synonyms |
Surface C-type lectin DC-SIGN; Probable mannose-binding C-type lectin DC-SIGN; MDC-SIGN1A type I isoform; Dendritic cell-specific ICAM-3-grabbing nonintegrin 1; Dendritic cell-specific ICAM-3-grabbing non-integrin 1; DC-specific ICAM-3 grabbing nonintegrin; DC-SIGN1; DC-SIGN; CLEC4L; CD209 antigen; CD 209; C-type lectin domain family 4 member L
Click to Show/Hide
|
||||
| Target Type | Literature-reported Target | ||||
| Gene Name | CD209 | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 2 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(2S,3S,4S,5S,6R)-2-[1,3-Bis[(7-methoxynaphthalen-2-yl)oxy]propan-2-yloxy]-6-(hydroxymethyl)oxane-3,4,5-triol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3121712; BDBM50448389
Click to Show/Hide
|
||||
| Activity |
IC50 = 50000 nM
|
[1] | |||
| Compound Name |
Chembl4283127
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50467901
Click to Show/Hide
|
||||
| Activity |
IC50 = 71000 nM
|
[2] | |||
| Non Binders of This Target (in total, 29 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
D-mannose
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
D-Mannose; Mannose; D-Mannopyranose; Seminose; Carubinose; Mannopyranose; Mannopyranoside; D-(+)-Mannose; 530-26-7; CHEBI:4208; DL-Mannose; D(+)-Mannose; (+-)-Mannose; (3S,4S,5S,6R)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol; D-Mannopyranoside; D-Man; WQZGKKKJIJFFOK-QTVWNMPRSA-N; Man; Mannopyranose, D-; SMR000857125; EINECS 208-474-2; D-Mannose,(S); alpha,beta-D-mannopyranose; bmse000018; bmse000882; Epitope ID:152206; bmse000874; AC1L2D5C; SCHEMBL38300; MLS001332528; MLS001332527; GTPL4650; CHEMBL469448; DTXSID5040463
Click to Show/Hide
|
||||
| Activity |
Ki = 13100000 nM
|
[1] | |||
| Compound Name |
(1S,2S,4S,5S)-4-(2-Azidoethoxy)-1-N,2-N-bis[[4-(hydroxymethyl)phenyl]methyl]-5-[(2S,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxycyclohexane-1,2-dicarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3121700; BDBM50448401
Click to Show/Hide
|
||||
| Activity |
IC50 = 325000 nM
|
[1] | |||
| Compound Name |
(2S,3S,4S,5S,6R)-2-(2,3-Dinaphthalen-2-yloxypropoxy)-6-(hydroxymethyl)oxane-3,4,5-triol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3121719; BDBM50448382
Click to Show/Hide
|
||||
| Activity |
IC50 = 395000 nM
|
[3] | |||
| Compound Name |
Chembl4294737
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50467902
Click to Show/Hide
|
||||
| Activity |
IC50 = 450000 nM
|
[2] | |||
| Compound Name |
(2S,3S,4S,5S,6R)-2-(2,3-Dinaphthalen-1-yloxypropoxy)-6-(hydroxymethyl)oxane-3,4,5-triol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3121717; BDBM50448384
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[3] | |||
| Compound Name |
(2R,3S,4S,5S,6S)-2-(Hydroxymethyl)-6-[2-(4-nitrophenoxy)-1-[(4-nitrophenoxy)methyl]ethoxy]tetrahydropyran-3,4,5-triol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3121710; BDBM50448391
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[3] | |||
| Compound Name |
(2S,3S,4S,5S,6R)-2-[2,3-Bis[(7-methoxynaphthalen-2-yl)oxy]propoxy]-6-(hydroxymethyl)oxane-3,4,5-triol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3121718; BDBM50448383
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[3] | |||
| Compound Name |
Dimethyl (1S,2S,4S,5S)-4-methoxy-5-[(2S,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxycyclohexane-1,2-dicarboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4095576; BDBM50260173
Click to Show/Hide
|
||||
| Activity |
IC50 = 720000 nM
|
[4] | |||
| Compound Name |
Dimethyl (1S,2S,4S,5S)-4-methoxy-5-[(2R,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]sulfanylcyclohexane-1,2-dicarboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4068200; BDBM50260172
Click to Show/Hide
|
||||
| Activity |
IC50 = 776000 nM
|
[4] | |||
| Compound Name |
Dimethyl (1S,2S,4S,5S)-4-(2,2-dimethylpropanoyloxy)-5-[(2R,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]sulfanylcyclohexane-1,2-dicarboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4061670; BDBM50260174
Click to Show/Hide
|
||||
| Activity |
IC50 = 776000 nM
|
[4] | |||
| Compound Name |
(2R,3S,4S,5S,6S)-2-(Hydroxymethyl)-6-[3-(4-hydroxyphenoxy)-2-(4-methoxyphenoxy)propoxy]oxane-3,4,5-triol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3596410
Click to Show/Hide
|
||||
| Activity |
IC50 = 1010000 nM
|
[3] | |||
| Compound Name |
(2S,3S,4S,5S,6R)-2-[2,3-Bis(4-methoxyphenoxy)propoxy]-6-(hydroxymethyl)oxane-3,4,5-triol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3121715; BDBM50448386
Click to Show/Hide
|
||||
| Activity |
IC50 = 1010000 nM
|
[1] | |||
| Compound Name |
(1S)-4alpha-(2-Azidoethoxy)-5beta-(alpha-D-mannopyranosyloxy)cyclohexane-1alpha,2beta-dicarboxylic acid dimethyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3121699; BDBM50448402; Dimethyl (1S,2S,4S,5S)-4-(2-azidoethoxy)-5-(alpha-D-mannopyranosyloxy)cyclohexane-1,2-dicarboxylate
Click to Show/Hide
|
||||
| Activity |
IC50 = 1020000 nM
|
[1] | |||
| Compound Name |
N-[3-(Naphthalene-2-carbonylamino)-2-[(2S,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxypropyl]naphthalene-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3121704; BDBM50448397
Click to Show/Hide
|
||||
| Activity |
IC50 = 1340000 nM
|
[3] | |||
| Compound Name |
Chembl4281622
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50467900
Click to Show/Hide
|
||||
| Activity |
IC50 = 1400000 nM
|
[2] | |||
| Compound Name |
(2R,3S,4S,5S,6S)-2-(Hydroxymethyl)-6-[2-phenoxy-1-(phenoxymethyl)ethoxy]tetrahydropyran-3,4,5-triol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3121708; BDBM50448393
Click to Show/Hide
|
||||
| Activity |
IC50 = 2410000 nM
|
[1] | |||
| Compound Name |
L-Fucose
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
6-Deoxy-Galactopyranose; 6-Deoxy-Galactopyranoside; 6-Deoxy-Galactose; 6-Deoxy-L-Galactopyranose; 6-Deoxy-L-Galactopyranoside; 6-Deoxy-L-Galactose; Fucose; L-Fuc; L-fucopyranose; (3S,4R,5S,6S)-6-Methyltetrahydro-2H-pyran-2,3,4,5-tetraol; L-galactomethylose; CHEMBL469449; 6-Desoxygalactose; (-)-L-Fucose; 6-Deoxy-L-beta-galactose; fucopyranose; L-Galactopyranose, 6-deoxy-; 6-methyltetrahydropyran-2,3,4,5-tetraol; bmse000036; Epitope ID:152214; Fucopyranose, L- (7CI); SCHEMBL63943; (3S,4R,5S,6S)-6-methyloxane-2,3,4,5-tetrol; a-L-Galactopyranose, 6-deoxy-; CTK5C5442; DTXSID501016770; BDBM50242419; L-Galactopyranose, 6-deoxy- (9CI); 6-deoxy-L-galactopyranoseL-fucopyranose; C01019; F-8060; Q409082; O_FULL_00100000000000_GS_657
Click to Show/Hide
|
||||
| Activity |
IC50 = 2950000 nM
|
[1] | |||
| Compound Name |
Chembl4281743
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50466359
Click to Show/Hide
|
||||
| Activity |
IC50 = 3200000 nM
|
[5] | |||
| Compound Name |
4-Methoxy-N-[3-[(4-methoxybenzoyl)amino]-2-[(2S,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxypropyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3121703; BDBM50448398
Click to Show/Hide
|
||||
| Activity |
IC50 = 3890000 nM
|
[3] | |||
| Compound Name |
4-Cyano-N-[3-[(4-cyanobenzoyl)amino]-2-[(2S,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxypropyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3121702; BDBM50448399
Click to Show/Hide
|
||||
| Activity |
IC50 = 4370000 nM
|
[3] | |||
| Compound Name |
(2R,3S,4S,5S,6S)-2-(Hydroxymethyl)-6-[2-(4-methoxyphenoxy)-1-[(4-methoxyphenoxy)methyl]ethoxy]tetrahydropyran-3,4,5-triol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3121709; BDBM50448392
Click to Show/Hide
|
||||
| Activity |
IC50 = 5150000 nM
|
[3] | |||
| Compound Name |
(2S,3S,4S,5S,6R)-2-[2,3-Bis(4-nitrophenoxy)propoxy]-6-(hydroxymethyl)oxane-3,4,5-triol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3121716; BDBM50448385
Click to Show/Hide
|
||||
| Activity |
IC50 = 5730000 nM
|
[3] | |||
| Compound Name |
2-(4-Nitrophenyl)-N-[3-[[2-(4-nitrophenyl)acetyl]amino]-2-[(2S,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxypropyl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3121707; BDBM50448394
Click to Show/Hide
|
||||
| Activity |
IC50 = 6490000 nM
|
[3] | |||
| Compound Name |
(2S,3S,4S,5S,6R)-2-(1-Ethoxy-3-naphthalen-2-yloxypropan-2-yl)oxy-6-(hydroxymethyl)oxane-3,4,5-triol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3121713; BDBM50448388
Click to Show/Hide
|
||||
| Activity |
IC50 = 7160000 nM
|
[1] | |||
| Compound Name |
(2S,3S,4S,5S,6R)-2-(2,3-Diphenoxypropoxy)-6-(hydroxymethyl)oxane-3,4,5-triol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3121714; BDBM50448387
Click to Show/Hide
|
||||
| Activity |
IC50 = 8640000 nM
|
[3] | |||
| Compound Name |
N-[3-Benzamido-2-[(2S,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxypropyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3121701; BDBM50448400
Click to Show/Hide
|
||||
| Activity |
IC50 = 8790000 nM
|
[3] | |||
| Compound Name |
N-Acetyl-D-Mannosamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-Acetamido-2-Deoxy-D-Mannopyranose; 2-Acetamido-2-Deoxy-D-Mannopyranoside; 2-Acetamido-2-Deoxy-D-Mannose; 2-Acetamido-2-Deoxy-Mannopyranose; 2-Acetamido-2-Deoxy-Mannopyranoside; 2-Acetamido-2-Deoxy-Mannose; 2-Deoxy-2-Acetamido-D-Mannopyranose; 2-Deoxy-2-Acetamido-D-Mannopyranoside; 2-Deoxy-2-Acetamido-D-Mannose; 2-Deoxy-2-Acetamido-Mannopyranose; 2-Deoxy-2-Acetamido-Mannopyranoside; 2-Deoxy-2-Acetamido-Mannose; D-ManNAc; ManNAc; N-Acetyl-Mannosamine; N-acetylmannosamine; CHEMBL509437; n-acetyl mannosamine; 6-Acetamido-6-deoxy-acpha-D-glucopyranose; bmse000056; Cyclic N-Acetyl-mannosamine; SCHEMBL5031262; BDBM50466361; MFCD00046758; 2-(Acetylamino)-2-deoxymannopyranose; AKOS024438105; N-[(3S,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide; 2-(Acetamido)-2-deoxy-D-mannopyranose; hexopyranose, 2-(acetylamino)-2-deoxy-; 2-(Acetylamino)-2-deoxy-D-mannopyranose; PS-11250; CS-0130226; A-9322; C00645; Q27132427; N-[2,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-3-yl]acetamide
Click to Show/Hide
|
||||
| Activity |
Ki = 11000000 nM
|
[5] | |||
| Compound Name |
N-[3-(1H-Pyrrole-2-carbonylamino)-2-[(2S,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxypropyl]-1H-pyrrole-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3121705; BDBM50448396
Click to Show/Hide
|
||||
| Activity |
IC50 = 13250000 nM
|
[3] | |||
| Compound Name |
2-Phenyl-N-[3-[(2-phenylacetyl)amino]-2-[(2S,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxypropyl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3121706; BDBM50448395
Click to Show/Hide
|
||||
| Activity |
IC50 = 14940000 nM
|
[3] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Monovalent mannose-based DC-SIGN antagonists: targeting the hydrophobic groove of the receptor. Eur J Med Chem. 2014 Mar 21;75:308-26. | ||||
| REF 2 | Genetically-encoded fragment-based discovery of glycopeptide ligands for DC-SIGN. Bioorg Med Chem. 2018 Oct 15;26(19):5368-5377. | ||||
| REF 3 | Branched alpha-d-mannopyranosides: a new class of potent FimH antagonists. Medchemcomm. 2014;5:1247-53. | ||||
| REF 4 | Facile access to pseudo-thio-1,2-dimannoside, a new glycomimetic DC-SIGN antagonist. Bioorg Med Chem. 2017 Oct 1;25(19):5142-5147. | ||||
| REF 5 | Chemistry-driven glycoscience. Bioorg Med Chem. 2018 Oct 15;26(19):5229-5238. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.