Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T59328 | Target Info | |||
| Target Name | Epidermal growth factor receptor (EGFR) | ||||
| Synonyms |
Receptor tyrosine-protein kinase erbB-1; Proto-oncogene c-ErbB-1; HER1; ERBB1; ERBB
Click to Show/Hide
|
||||
| Target Type | Successful Target | ||||
| Gene Name | EGFR | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 605 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Romiplostim
Click to Show/Hide
|
Approved | Compound Info | ||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Imatinib
Click to Show/Hide
|
Approved | Compound Info | ||
| Synonyms |
Cgp 57148; Glamox; Glamox (TN); Gleevec (TN); Glivec (TN); Imatinib (INN); Imatinib (STI571); Imatinib Methansulfonate; Imatinib [INN:BAN]; 112GI019; 152459-95-5; BKJ8M8G5HI; CCRIS 9076; CGP-57148; CHEMBL941; Imatinib free base; STI; UNII-BKJ8M8G5HI
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Adenosine
Click to Show/Hide
|
Approved | Compound Info | ||
| Synonyms |
Adenosine, homopolymer; Adenine 9-beta-D-arabinofuranoside; Adenine-9-beta-D-ribofuranoside; Beta-D-Ribofuranoside, adenine-9; EA6C60C2-6AFB-4264-A2F0-541373DB950E; (2R,3R,4S,5R)-2-(6-Aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol; (2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol; 4-Aminopyrazolo[3,4-d]pyrimidine ribonucleoside; 6-Amino-9-.beta.-ribofuranosyl-9H-purine; 6-Amino-9-beta-D-ribofuranosyl-9H-purine; 6-Amino-9beta-D-ribofuranosyl-9H-purine; 9-(beta-D-Arabinofuranosyl)adenine; 9-beta-D-Ribofuranosidoadenine; 9-beta-D-Ribofuranosyl-9H-purin-6-amine; 9-beta-D-Ribofuranosyladenine; 9beta-D-Ribofuranosyladenine
Click to Show/Hide
|
||||
| Activity |
IC50 = 195000 nM
|
[3] | |||
| Compound Name |
HIF-1alpha
Click to Show/Hide
|
Phase 4 | Compound Info | ||
| Synonyms |
Unii-NA856793UT; 192705-79-6; PD-166866; PD166866; PD 166866; UNII-NA856793UT; CHEMBL299763; NA856793UT; 1-[2-amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylurea; 1-(2-Amino-6-(3,5-dimethoxyphenyl)-pyrido(2,3-d)pyrimidin-7-yl)-3-tert-butyl urea; Urea,N-[2-amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)-; 1-[2-Amino-6-(3,5-dimethoxyphenyl)-pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butyl urea; 6-arylpyrido[2,3-d]pyrimidine deriv 25; AC1NS3U5; SCHEMBL1248489; BDBM3443; CTK4E1060
Click to Show/Hide
|
||||
| Activity |
IC50 = 50000 nM
|
[4] | |||
| Compound Name |
PF-06651600
Click to Show/Hide
|
Phase 2/3 | Compound Info | ||
| Synonyms |
CBRJPFGIXUFMTM-WDEREUQCSA-N; 1792180-81-4; UNII-2OYE00PC25; 2OYE00PC25; PF06651600; 1-((2S,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one; GTPL9559; SCHEMBL16764638; BCP24778; EX-A2613; ZINC526061581; example 5 [WO2015083028]; ACN-040697; compound 11 [PMID: 28139931]; HY-100754; CS-0020243; 1-[(2S,5R)-2-Methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-1-piperidinyl]-2-propen-1-one malonate; 1-[(2S,5R)-2-methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)piperidin-1-yl]prop-2-en-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
PD173074
Click to Show/Hide
|
Phase 2 | Compound Info | ||
| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
Staurosporine
Click to Show/Hide
|
Phase 2 | Compound Info | ||
| Synonyms |
staurosporine; Staurosporin; (+)-Staurosporine; Antibiotic 230; 62996-74-1; Antibiotic AM 2282; CCRIS 3272; AM-2282; UNII-H88EPA0A3N; Alkaloid AM-2282 from Streptomyces; H88EPA0A3N; CHEMBL388978; CHEBI:15738; CGP 39360; 8,12-Epoxy-1H,8H-2,7b,12a-triazadibenzo(a,g)cyclonona(cde)trinden-1-one, 2,3,9,10,11,12-hexahydro-9-methoxy-8-methyl-10-(methylamino)-, (8alpha,9beta,10beta,12alpha)-(+)-
Click to Show/Hide
|
||||
| Activity |
IC50 = 178000 nM
|
[7] | |||
| Compound Name |
Imatinib and nilotinib derivative 1
Click to Show/Hide
|
Patented | Compound Info | ||
| Synonyms |
PMID30074415-Compound-22
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
PMID28460551-Compound-2
Click to Show/Hide
|
Patented | Compound Info | ||
| Activity |
IC50 = 172100 nM
|
[8] | |||
| Compound Name |
Flavonoid derivative 4
Click to Show/Hide
|
Patented | Compound Info | ||
| Synonyms |
PMID26394986-Compound-48
Click to Show/Hide
|
||||
| Activity |
IC50 = 190000 nM
|
[9] | |||
| Compound Name |
SB 203580
Click to Show/Hide
|
Terminated | Compound Info | ||
| Synonyms |
152121-47-6; SB-203580; SB203580; 4-(4-(4-fluorophenyl)-2-(4-(methylsulfinyl)phenyl)-1H-imidazol-5-yl)pyridine; 4-(4-Fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-5-(4-pyridyl)-1H-imidazole; CHEBI:90705; 4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole; CHEMBL10; RWJ 64809; 4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole; 4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine; PB 203580; UNII-WS78QR6DSV
Click to Show/Hide
|
||||
| Activity |
IC50 = 96000 nM
|
[10] | |||
| Compound Name |
BMS-509744
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BMS-509744; 439575-02-7; BMS 509744; CHEMBL209148; N-(5-((5-(4-Acetylpiperazine-1-carbonyl)-4-methoxy-2-methylphenyl)thio)thiazol-2-yl)-4-(((3,3-dimethylbutan-2-yl)amino)methyl)benzamide; N-[5-[5-(4-acetylpiperazine-1-carbonyl)-4-methoxy-2-methylphenyl]sulfanyl-1,3-thiazol-2-yl]-4-[(3,3-dimethylbutan-2-ylamino)methyl]benzamide; GTPL9994; SCHEMBL14460651; KS-00001CVA; CHEBI:91404; MolPort-039-101-283; C32H41N5O4S2; BMS509744; BDBM50186460; 3499AH; compound 3 [PMID:16682193]; AKOS025142036; NCGC00229512-02; NCGC00229512-01
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[11] | |||
| Compound Name |
A-432411
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
43A; (3Z)-6-(4-HYDROXY-3-METHOXYPHENYL)-3-(1H-PYRROL-2-YLMETHYLENE)-1,3-DIHYDRO-2H-INDOL-2-ONE; 2ayp; indolinone analog 13; A-432411; CHEMBL202930; SCHEMBL6674605; BDBM14649; DB07078; 29690-EP2311842A2; 29690-EP2289868A1; 29690-EP2289894A2; (3Z)-6-(4-hydroxy-3-methoxyphenyl)-3-(1H-pyrrol-2-ylmethylidene)-1H-indol-2-one; (3Z)-6-(4-hydroxy-3-methoxyphenyl)-3-(1H-pyrrol-2-ylmethylidene)-2,3-dihydro-1H-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[12] | |||
| Compound Name |
RO-316233
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
119139-23-0; bisindolylmaleimide iv; 3,4-di(1H-indol-3-yl)-1H-pyrrole-2,5-dione; Arcyriarubin A; 3,4-Bis(3-indolyl)maleimide; 3,4-Di-1H-indol-3-yl-1H-pyrrole-2,5-dione; UNII-MBK3OO5K8T; BIM IV; 3,4-bis(1H-indol-3-yl)pyrrole-2,5-dione; MBK3OO5K8T; CHEMBL266487; 3,4-bis(1H-indol-3-yl)-2,5-dihydro-1H-pyrrole-2,5-dione; DQYBRTASHMYDJG-UHFFFAOYSA-N; 2,3-bis(1H-Indol-3-yl)maleimide; 1H-Pyrrole-2,5-dione, 3,4-di-1H-indol-3-yl-; Ro-31-6233; AK-15401; 3,4-bis(3-indolyl)-1H-pyrrole-2,5-dione; Bisindoylmaleimide; Bisindolyl deriv. 3
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[13] | |||
| Compound Name |
(Z)-3-((1H-pyrrol-2-yl)methylene)indolin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
oxindole i; CHEMBL86755; 3-(1H-Pyrrol-2-ylmethylene)-1,3-dihydroindol-2-one; oxindole 1; AC1NZGXV; K00027; (Z)-3-((1H-pyrrol-2-yl)methylene)indolin-2-one; Indolinone based inhibitor, 1; SCHEMBL1162655; SCHEMBL13819612; BDBM17015; MolPort-023-197-743; SEZFNTZQMWJIAI-FLIBITNWSA-N; ZINC3874586; HSCI1_000049; NCGC00343760-01; BRD-K51816706-001-01-7; (3Z)-3-(1H-pyrrol-2-ylmethylidene)-1H-indol-2-one; 3-[(1H-Pyrrole-2-yl)methylene]-1H-indole-2(3H)-one; Z-(1H-Pyrrol-2-ylmethylene)-1,3-dihydro-indol-2-one; Oxindole I
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
Indolin-2-one deriv. 4b
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
indolin-2-one deriv. 4b
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
JNJ-7706621
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
JNJ-7706621; 443797-96-4; JNJ7706621; 4-((5-Amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl)amino)benzenesulfonamide; UNII-74GK72DON8; RWJ-387252; 4-[[5-amino-1-(2,6-difluorobenzoyl)-1,2,4-triazol-3-yl]amino]benzenesulfonamide; CHEMBL191003; 74GK72DON8; 4-[[5-Amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl]amino]benzenesulfonamide; JNJ 7706621; 4-(5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-ylamino)benzenesulfonamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
VEGF receptor 2 kinase inhibitor I
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
VEGF Receptor 2 Kinase Inhibitor I; UNII-U07H877HUF; CHEMBL86943; U07H877HUF; 15966-93-5; (Z)-3-[(2,4-Dimethyl-3-(ethoxycarbonyl)pyrrol-5-yl)methylidenyl]indolin-2-one; Vegfr-2 inhi; ethyl 2,4-dimethyl-5-{[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-1H-pyrrole-3-carboxylate; Ethyl 2,4-dimethyl-5-(((3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene)methyl)-1H-pyrrole-3-carboxylate; AC1O4WEX; K00004; Vegfr 2 kinase inhibitor I; SCHEMBL378979; VEGFR2 KiN/Ase Inhibitor I; GTPL6053; MolPort-044-561-167; HMS3229O05; ZINC3875265
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
SU4984
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SU-4984; CHEMBL315546; 3[4-(1-Formylpiperazin-4-yl)benzylidenyl]-2-indolinone; (Z)-4-(4-((2-Oxoindolin-3-ylidene)methyl)phenyl)piperazine-1-carbaldehyde; 186610-89-9; AC1NZT45; SCHEMBL141892; BDBM50065306; ZINC12832813; 4-[4-[(Z)-(2-oxo-1H-indol-3-ylidene)methyl]phenyl]piperazine-1-carbaldehyde
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
4-(3,4-Dimethoxy-phenoxy)-6,7-dimethoxy-quinoline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL327300; Ki-6783; 6,7-Dimethoxy-4-(3,4-dimethoxyphenoxy)quinoline; SCHEMBL925876; 4-(3,4-Dimethoxy-phenoxy)-6,7-dimethoxy-quinoline; ZQSHUGGLESWJFP-UHFFFAOYSA-N
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[18] | |||
| Compound Name |
JNJ-10198409
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
JNJ-10198409; 627518-40-5; PDGFR Tyrosine Kinase Inhibitor IV; PDGF Receptor Tyrosine Kinase Inhibitor IV; CHEMBL120077; N-(3-fluorophenyl)-6,7-dimethoxy-1,4-dihydroindeno[1,2-c]pyrazol-3-amine; 3-Fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamine; ZDNURMVOKAERHZ-UHFFFAOYSA-N; SCHEMBL3088170; GTPL6020; CTK8E8807; jnj10198409; DTXSID70430890; MolPort-009-019-131; HMS3650O03; HMS3229I11; ZINC13677843; BDBM50179207; AKOS030525202; RWJ 540973; CCG-206773; NCGC00343986-02; RT-014973; KB-274227; SR-01000946814
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
(4-Ethyl-phenyl)-(6,7,8,9-tetrahydro-5H-pyrimido[4,5-b]indol-4-yl)-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL72984; SCHEMBL2461513; BDBM50051324
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[19] | |||
| Compound Name |
N-Phenyl-4,5-dianilinophthalimide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL8000; BDBM50040922; 2-Phenyl-5,6-bis-phenylamino-isoindole-1,3-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[13] | |||
| Compound Name |
(2R)-N-Benzyl-3-[2-[[3-[(2S)-3-(benzylamino)-3-oxo-2-[(2,2,2-trifluoroacetyl)amino]propyl]-1H-indol-2-yl]selanyl]-1H-indol-3-yl]-2-[(2,2,2-trifluoroacetyl)amino]propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL135241
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[20] | |||
| Compound Name |
3-Substituted indolin-2-one 11c
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SU5402 analog 11c; BDBM4889; CHEMBL146697; SCHEMBL4407240; 3-[4-Methyl-5-(2-oxo-5-sulfamoyl-1,2-dihydroindol-3-ylidenemethyl)-1H-pyrrol-3-yl]propionic Acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
3-Substituted indolin-2-one 16i
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM4903; CHEMBL150151; SCHEMBL4408517
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Ethyl 4-[[6-(2,6-dichlorophenyl)-8-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl]amino]benzoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 56; BDBM3089; CHEMBL109525; SCHEMBL6291747; ZINC3832346; DA-21522; ethyl 4-{[6-(2,6-dichlorophenyl)-8-methyl-7-oxo-7H,8H-pyrido[2,3-d]pyrimidin-2-yl]amino}benzoate
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[21] | |||
| Compound Name |
4'-Tert-Butyl-2'-(methoxymethoxy)-1,1'-biphenyl-4-carboxylic acid 2,4,4-trimethylpentyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL357695; BDBM50029738; 4''-tert-Butyl-2''-methoxymethoxy-biphenyl-4-carboxylic acid 2,4,4-trimethyl-pentyl ester
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[22] | |||
| Compound Name |
Methyl-(1H-pyrazolo[3,4-d]pyrimidin-4-yl)-m-tolyl-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL136011; SCHEMBL14040850; BDBM50291110
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[23] | |||
| Compound Name |
N-(7-Methoxyquinolin-6-yl)thieno[3,2-d]pyrimidine-7-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL357756; CHEMBL3822972; BDBM206104; DB-085143; US9255110, 17
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[24] | |||
| Compound Name |
N-Methyl-N-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL541334
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[23] | |||
| Compound Name |
4-[4-(5-Bromo-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-phenyl]-piperazine-1-carbaldehyde
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL88405; BDBM50065299; 4-{4-[5-Bromo-2-oxo-1,2-dihydro-indol-(3Z)-ylidenemethyl]-phenyl}-piperazine-1-carbaldehyde
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[14] | |||
| Compound Name |
N4-(3-Bromophenyl)-6-(3,4,5-trimethoxybenzyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL514014; BDBM50292735
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[25] | |||
| Compound Name |
6-(2,6-Dichlorophenyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL50977; BDBM50064347; 6-(2,6-dichlorophenyl)-8-methylpyrido[2,3-d]pyrimidin-7-one; 6-(2,6-Dichloro-phenyl)-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one; 6-(2,6-Dichlorophenyl)-8-methylpyrido[2,3-d]pyrimidine-7(8H)-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[26] | |||
| Compound Name |
N-[1-(4-Hydroxycyclohexyl)-4-methylbenzimidazol-2-yl]-3-(trifluoromethyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3918367; BDBM50196238
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[27] | |||
| Compound Name |
N4-(3-Bromophenyl)-6-(naphthalen-1-ylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL474538; BDBM50247802; 5H-1,2,4-Triazino[5,6-b]indole, 3-(1-imidazolidinyl)-5,8-dimethyl-; N4-(3-bromophenyl)-2-(naphthalen-1-ylmethyl)-1H-indole-4,6-diamine; N4-(3-bromophenyl)-6-(1-naphthylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[25] | |||
| Compound Name |
(3r)-1-{2-[4-(4-Acetylphenyl)piperazin-1-Yl]-2-Oxoethyl}-N-(3-Chloro-4-Hydroxyphenyl)pyrrolidine-3-Carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3356117; SCHEMBL7878839; BDBM50030881; Q27453793
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[28] | |||
| Compound Name |
beta-Carbamoyl-beta-cyano-3,5-di-tert-butyl-4-hydroxystyrene
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-Propenamide, 3-(3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl)-2-cyano-; benzylidenemalononitrile (BMN) deriv. 45; 3-(3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl)-2-cyano-2-propenamide; BDBM4361; CHEMBL490570; SCHEMBL11093690; (E)-2-cyano-3-(3,5-ditert-butyl-4-hydroxyphenyl)prop-2-enamide; ZINC3165704; AKOS024367844; ST51001882; 2-Cyano-3-(4-hydroxy-3,5-di-tert-butylphenyl)propenamide; (E)-3-(4-Hydroxy-3,5-di-tert-butylphenyl)-2-cyanoacrylamide; (2E)-2-cyano-3-(3,5-di-tert-butyl-4-hydroxyphenyl)prop-2-enamide; (2E)-3-[3,5-bis(tert-butyl)-4-hydroxyphenyl]-2-cyanoprop-2-enamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 50000 nM
|
[29] | |||
| Compound Name |
4,5-Bis[phenyl(methyl)amino]phthalimide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL267941; SCHEMBL8834735; BDBM50040918; 4,5-Bis(N-methyl-N-phenylamino)phthalimide; 5,6-bis(N-methylanilino)isoindole-1,3-dione; 5,6-Bis-(methyl-phenyl-amino)-isoindole-1,3-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[13] | |||
| Compound Name |
Malononitrile, 5-bromovanillylidene-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-[(3-bromo-4-hydroxy-5-methoxyphenyl)methylidene]propanedinitrile; 2-(3-bromo-4-hydroxy-5-methoxybenzylidene)malononitrile; 5-BROMOVANILLYLIDENEMALONONITRILE; BRN 3324020; 5-Bromo vanillylidenemalononitrile; 4-10-00-02306 (Beilstein Handbook Reference); CHEMBL77298; BDBM4334; SCHEMBL4328828; CTK5I0840; DTXSID80244364; ZINC283348; MCK102958; AKOS002952031; MCULE-6915371890; benzylidenemalononitrile (BMN) deriv. 18; SR-01000202944; 3-Bromo-4-hydroxy-5-methoxybenzylidene-malononitrile; SR-01000202944-1
Click to Show/Hide
|
||||
| Activity |
Ki = 50000 nM
|
[30] | |||
| Compound Name |
3-Substituted indolin-2-one 9d
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SU5402 analog 9d; BDBM4886; CHEMBL443296; SCHEMBL6390254
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
3-[(E)-2-(4-Chlorophenyl)ethenyl]-N-[(2R)-2,3-dihydroxypropyl]-4-methoxybenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1949788; SCHEMBL12134179; BDBM50364832; CH-4932748
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[31] | |||
| Compound Name |
1-Butyl-1-(2-hydroxy-5-methylbenzyl)-3-phenylurea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL591707; BDBM50308649
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[32] | |||
| Compound Name |
[4-[(E)-2-Nitroethenyl]phenyl] 4-[[(2S)-1-[[(2S)-1-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethylamino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]carbamoyl]benzenesulfonate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL444470; BDBM50292529
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[29] | |||
| Compound Name |
2-Hydroxy-5-[(2,5-dihydroxybenzylidene)amino]benzoic acid ethyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL354521; BDBM50453609
Click to Show/Hide
|
||||
| Activity |
IC50 = 50000 nM
|
[33] | |||
| Compound Name |
N-[5-Methyl-1-[3-(prop-2-enoylamino)phenyl]benzimidazol-2-yl]-3-(trifluoromethyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3959632; SCHEMBL16755416; BDBM50196103
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[27] | |||
| Compound Name |
4-(2-Methoxyethyl)phenol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
p-(2-Methoxyethyl)phenol; p-(2-Methoxyethyl) phenol; Phenol, 4-(2-methoxyethyl)-; 4-METHOXYETHYLPHENOL; UNII-PY1W0AKW8I; Metoprolol Impurity B; Metoprolol IMpurity 02; MFCD00017537; PY1W0AKW8I; CHEMBL1094369; 4-Hydroxyphenylethyl methyl ether; 4-(2'-METHOXYETHYL)PHENOL; Metoprolol Impurity I; 4-(2-methoxyethyl)-phenol; 4-(2-Methoxy ethyl)-phenol; EINECS 260-354-9; 4-Methoxy ethyl phenol; ACMC-1AUK5; 4-(2'Methoxyethyl)Phenol; EC 260-354-9; 4-(2-methoxy ethyl)phenol; 4-(2-methoxyethyl) phenol; 4-(2-methoxy ethyl) phenol; 4-(2-methoxy-ethyl)-phenol; KSC495I9L; SCHEMBL303516; p-Hydroxyphenethyl methyl ether; DTXSID2073564; CTK3J5495; ATTERCOP-CHM AT108983; 4-(2-Methoxyethyl)phenol, 97%; CS-M3678; KS-000009AQ; ZINC2566176; ANW-32571; BDBM50316786; AKOS000120544; AS00207; MCULE-8081983402; NE10781; AC-23553; TS-02027; DB-052961; FT-0616546; FT-0652026; M1167; ST50824360; W-105505; Q27286814
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[34] | |||
| Compound Name |
[6-Chloro-4-methyl-3-[[3-(methylsulfamoylamino)phenyl]methyl]-2-oxochromen-7-yl] N,N-dimethylcarbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3086065; SCHEMBL959662; BDBM50443366
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[35] | |||
| Compound Name |
N-[5-Methyl-1-[2-(prop-2-enoylamino)phenyl]benzimidazol-2-yl]-3-(trifluoromethyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3935558; SCHEMBL16755450
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[27] | |||
| Compound Name |
3-[3-(Benzothiazol-2-ylsulfanylmethyl)-4,5-dihydroxy-phenyl]-2-cyano-acrylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL333553; BDBM50036692; alpha-Carbamoyl-3-[(benzothiazol-2-ylthio)methyl]-4,5-dihydroxybenzenepropenenitrile
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[36] | |||
| Compound Name |
6,6-Dimethyl-8-(1-(oxetan-3-yl)piperidin-4-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1779202; SCHEMBL897210; BDBM50344664; 6,6-dimethyl-8-[1-(oxetan-3-yl)piperidin-4-yl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[37] | |||
| Compound Name |
(R)-3-(6-(1-(2,6-Dichloro-3-fluorophenyl)ethoxy)quinolin-3-yl)acrylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL602471; BDBM50306677
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[38] | |||
| Compound Name |
N-[5-Methyl-1-[4-(prop-2-enoylamino)cyclohexyl]benzimidazol-2-yl]-3-(trifluoromethyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3944524; CHEMBL3962999; SCHEMBL16755384; SCHEMBL16755385; SCHEMBL16767975; SCHEMBL16769963
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[27] | |||
| Compound Name |
N-[5-Methyl-1-[3-(prop-2-enoylamino)propyl]benzimidazol-2-yl]-3-(trifluoromethyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3966111; SCHEMBL16755397; BDBM50196097
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[27] | |||
| Compound Name |
N-(4-Acetylphenyl)-1H-indole-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3797839; SCHEMBL15478841; BDBM50165848; AKOS008916268
Click to Show/Hide
|
||||
| Activity |
IC50 = 50000 nM
|
[39] | |||
| Compound Name |
Chembl4214588
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50453888
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[40] | |||
| Compound Name |
(E)-2-Cyano-3-[3-(4,5-dihydro-thiazol-2-ylsulfanylmethyl)-4-hydroxy-5-methoxy-phenyl]-acrylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL324030; BDBM50036681; alpha-Carbamoyl-3-[[(2-thiazolin-2-yl)thio]methyl]-4-hydroxy-5-methoxybenzenepropenenitrile; 2-Cyano-3-[3-(4,5-dihydro-thiazol-2-ylsulfanylmethyl)-4-hydroxy-5-methoxy-phenyl]-acrylamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[36] | |||
| Compound Name |
7-((4-Methylpiperazin-1-yl)methyl)-3-(thiophen-3-yl)-1,4-dihydroindeno[1,2-c]pyrazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL213743; BDBM50188266
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[41] | |||
| Compound Name |
3-[(E)-2-(4-Chlorophenyl)ethenyl]-N-[(2S)-2,3-dihydroxypropyl]-4-methoxybenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1949789; SCHEMBL12134185; BDBM50364833; CH-4932750
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[31] | |||
| Compound Name |
1-Butyl-1-(2-hydroxy-3,5-dimethylbenzyl)-3-phenylurea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL590997; BDBM50308652
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[32] | |||
| Compound Name |
2-[5-(2,2-Dicyano-vinyl)-2-hydroxy-3-methoxy-benzylsulfanyl]-benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL118321; BDBM50036695; 2-[5-(2,2-Dicyano-vinyl)-2-hydroxy-3-methoxy-benzylsulfanyl]-benzoic acid anion
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[36] | |||
| Compound Name |
(R)-6-(1-(2,6-Dichloro-3-fluorophenyl)ethoxy)quinoline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL600795; BDBM50306683
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[38] | |||
| Compound Name |
2-[5-[(2,5-Dihydroxyphenyl)methylideneamino]-2-hydroxyphenyl]-N-phenylmethoxyacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL352591; BDBM50453573
Click to Show/Hide
|
||||
| Activity |
IC50 = 50000 nM
|
[33] | |||
| Compound Name |
CID 49806721
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1823221; SCHEMBL896410; BDBM50352760; 9-ethyl-6,6-dimethyl-8-[4-(oxetan-3-yl)piperazin-1-yl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[37] | |||
| Compound Name |
Serotonin hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
5-Hydroxytryptamine hydrochloride; Serotonin HCl; 3-(2-aminoethyl)-1H-indol-5-ol hydrochloride; 5-Hydroxytryptamine HCl; 1H-Indol-5-ol, 3-(2-aminoethyl)-, monohydrochloride; UNII-GKN429M9VS; MFCD00012686; 3-(2-Aminoethyl)-5-hydroxyindole hydrochloride; GKN429M9VS; CHEMBL535832; 5-Hydroxytryptamine hydrochioride; 3-(2-aminoethyl)indol-5-ol, chloride; 3-(2-aminoethyl)-1H-indol-5-ol;hydrochloride; Serotonin hydrochloride, 98+%; SMR000875214; Prestwick_447; CCRIS 4420; SR-01000075577; Serotonin, HCl; 5-HT hydrochloride; 3-(2-Aminoethyl)indol-5-ol hydrochloride; MLS001332607; MLS001332608; MLS002153834; SCHEMBL379650; Serotonin hydrochloride(5-HT); Serotonin hydrochloride, powder; 3-(2-AMINO-ETHYL)-1H-INDOL-5-OL HYDROCHLORIDE; CTK3J3022; DTXSID80165186; 5-hydroxy tryptamine hydrochloride; HMS1569B03; 3-(2-Aminoethyl)indol-5-ol HCl; BCP20357; HY-B1473; KS-00000FV4; EINECS 244-464-4; Tox21_500607; ANW-43151; s4244; SBB003418; 5-Hydroxytryptamine Hydrochloride,(S); AKOS016010442; CCG-214216; GS-3130; LP00607; MCULE-8194058321; QC-1340; 3-(2-Aminoethyl)-1H-indol-5-ol HCl; NCGC00093982-01; NCGC00093982-02; NCGC00261292-01; SC-80561; ST056223; SY061788; AB0013658; DB-043206; CS-0013171; EU-0100607; FT-0631852; S0370; SW196666-3; A16699; H 9523; H-8140; X-1770; 3-(2-aminoethyl)-1H-indol-5-ol, hydrochloride; 3-(2-aminoethyl)-1H-indol-5-ol;hydrochloride.; 3-(2-azanylethyl)-1H-indol-5-ol hydrochloride; 153S980; A809482; 5-Hydroxytryptamine hydrochloride;5-HT hydrochloride; SR-01000075577-1; SR-01000075577-5; Q27279146
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[34] | |||
| Compound Name |
1-(3-(8-(Pyridin-4-ylmethylamino)imidazo[1,2-a]pyrazin-6-yl)phenyl)-3-(3-(trifluoromethyl)phenyl)urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1081198; SCHEMBL5480112; BDBM50312153
Click to Show/Hide
|
||||
| Activity |
IC50 = 50000 nM
|
[42] | |||
| Compound Name |
4,5-Bis[4-(diethylamino)anilino]phthalimide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL8223; BDBM50040921; 5,6-Bis-(4-diethylamino-phenylamino)-isoindole-1,3-dione
Click to Show/Hide
|
||||
| Activity |
IC50 = 50000 nM
|
[13] | |||
| Compound Name |
[5-(2,2-Dicyano-vinyl)-2-hydroxy-3-methoxy-benzylsulfanyl]-acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL120719; BDBM50036682
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[36] | |||
| Compound Name |
2-((4-Amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-(o-tolyl)quinazolin-4(3H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
PIK-294; PIK294; PIK 294; C28H23N7O2; cc-610; MLS006010993; SCHEMBL1952680; CHEMBL1241767; BDBM36411; AOB6611; DTXSID20648004; SYN1098; HMS3244E13; HMS3244E14; HMS3244F13; HMS3655P12; BCP01970; EX-A2568; s2227; ZINC62260316; AKOS026750411; CCG-269607; CS-3528; CID24905149; NCGC00346614-01; NCGC00346614-02; NCGC00346614-07; AC-32796; AK176035; AS-16244; HY-10303; QC-11467; SMR004702793; PIK-294, >=98% (HPLC); FT-0699808; SW220212-1; X7436; Z-3176; J-505227
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[43] | |||
| Compound Name |
1-[4-(4-Amino-6-methylthieno[2,3-d]pyrimidin-5-yl)phenyl]-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Thienopyrimidine deriv. 28; BDBM8846; CHEMBL381207; SCHEMBL4466103
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[44] | |||
| Compound Name |
4,5-Bis(cyclohexylamino)phthalimide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL266969; 5,6-bis(cyclohexylamino)isoindole-1,3-dione; SCHEMBL8834712; BDBM50040912; 5,6-Bis-cyclohexylamino-isoindole-1,3-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[13] | |||
| Compound Name |
N-(4-Pyridin-3-yl-pyrimidin-2-yl)-benzene-1,3-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL57553; SCHEMBL1465; BDBM50045528; VCC415532; 4-(3-Pyridinyl)-N-(3-aminophenyl)pyrimidin-2-amine; N-(3-aminophenyl)-4-(3-pyridyl)-2-pyrimidine-amine; 3-N-(4-pyridin-3-ylpyrimidin-2-yl)benzene-1,3-diamine; N-[4-(pyridin-3-yl)pyrimidin-2-yl]benzene-1,3-diamine; N1-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
Click to Show/Hide
|
||||
| Activity |
IC50 = 50000 nM
|
[2] | |||
| Compound Name |
3-Substituted indolin-2-one 11a
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SU5402 analog 11a; BDBM4887; CHEMBL344319; SCHEMBL4407207; 3-[4-Methyl-5-(2-oxo-1,2-dihydroindol-3-ylidenemethyl)-1H-pyrrol-3-yl]propionic Acid; 3-(4-methyl-5-{[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-1H-pyrrol-3-yl)propanoic acid; 3-[2-[(2,3-Dihydro-2-oxo-1H-indole-3-ylidene)methyl]-3-methyl-1H-pyrrole-4-yl]propanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Chembl4207984
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50453889
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[40] | |||
| Compound Name |
Chembl4218431
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50453890
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[40] | |||
| Compound Name |
N-[3-[(4-Pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL277931; SCHEMBL9197; BDBM50175493; N-[3-(4-Pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
N-[1-(4-Hydroxycyclohexyl)-6-methylbenzimidazol-2-yl]-3-(trifluoromethyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3909438; BDBM50196236
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[27] | |||
| Compound Name |
N-[5-Methyl-1-[3-(prop-2-enoylamino)cyclopentyl]benzimidazol-2-yl]-3-(trifluoromethyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3892960; SCHEMBL16755423
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[27] | |||
| Compound Name |
N-[3-[(4-Pyridin-3-ylpyrimidin-2-yl)amino]phenyl]thiophene-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL56359; SCHEMBL1762; BDBM50290427; Thiophene-2-carboxylic acid [3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-amide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
6-(2,6-Dichlorophenyl)-2-(dimethylamino)-8-methylpyrido[2,3-d]pyrimidin-7-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL299347; 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 28; BDBM3061; SCHEMBL5761783; 2-(Dimethylamino)-6-(2,6-dichlorophenyl)-8-methylpyrido[2,3-d]pyrimidine-7(8H)-one; 6-(2,6-dichlorophenyl)-2-(dimethylamino)-8-methyl-7H,8H-pyrido[2,3-d]pyrimidin-7-one; 6-(2,6-Dichlorophenyl)-2-dimethylamino-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[21] | |||
| Compound Name |
2-Cyano-3-[4-hydroxy-3-[[(2-carboxyphenyl)thio]methyl]-5-methoxyphenyl]propenamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL119987; BDBM50036688; 2-[5-(2-Carbamoyl-2-cyano-vinyl)-2-hydroxy-3-methoxy-benzylsulfanyl]-benzoic acid; 2-[5-((E)-2-Carbamoyl-2-cyano-vinyl)-2-hydroxy-3-methoxy-benzylsulfanyl]-benzoic acid anion
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[36] | |||
| Compound Name |
1-Butyl-1-(3,5-dichloro-2-hydroxybenzyl)-3-phenylturea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL591708; BDBM50308650
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[32] | |||
| Compound Name |
N-[5-Methyl-1-[(1R,3S)-3-(prop-2-enoylamino)cyclohexyl]benzimidazol-2-yl]-3-(trifluoromethyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3953221; SCHEMBL16755447; BDBM50196102
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[27] | |||
| Compound Name |
4-(Bis(2-chloroethyl)amino)-N-(3-morpholinopropyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL589846; BDBM50308942
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[45] | |||
| Compound Name |
Flavopiridol analogue 16
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM5710; CHEMBL334881; SCHEMBL8681635
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[46] | |||
| Compound Name |
n-Methyl-4,5-dianilinophthalimide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL8036; SCHEMBL9381294; BDBM50040923; 4,5-Bis(anilino)-N(2) -methyl-phthalimide; 5,6-dianilino-2-methylisoindole-1,3-dione; 2-Methyl-5,6-bis-phenylamino-isoindole-1,3-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[13] | |||
| Compound Name |
3-[5-(2-Carbamoyl-2-cyano-vinyl)-2-hydroxy-3-methoxy-benzylsulfanyl]-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL424625; BDBM50036703
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[36] | |||
| Compound Name |
3-Substituted indolin-2-one 16d
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM4898; CHEMBL150177
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
2-(Benzylamino)-6-(2,6-dichlorophenyl)-8-methylpyrido[2,3-d]pyrimidin-7-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 27; BDBM3060; CHEMBL113356; SCHEMBL5764908; 2-(benzylamino)-6-(2,6-dichlorophenyl)-8-methyl-7H,8H-pyrido[2,3-d]pyrimidin-7-one; 2-Benzylamino-6-(2,6-dichlorophenyl)-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[21] | |||
| Compound Name |
3''-Tert-Butyl-5''-hydroxy-biphenyl-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL142420; BDBM50029737; ZINC13603854
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[22] | |||
| Compound Name |
N-[5-Methyl-1-[(1R,3R)-3-(prop-2-enoylamino)cyclohexyl]benzimidazol-2-yl]-3-(trifluoromethyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3973973; SCHEMBL16769987; BDBM50196098
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[27] | |||
| Compound Name |
2-(1H-Benzimidazol-2-ylmethyl)-5-[(2-methylphenyl)methyl]-1,3,4-oxadiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4095195; BDBM50232343
Click to Show/Hide
|
||||
| Activity |
IC50 = 50000 nM
|
[47] | |||
| Compound Name |
Pyrrolo[2,3-d]pyrimidin-6-one deriv. 26f
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM5128; CHEMBL305194; SCHEMBL6217722
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[48] | |||
| Compound Name |
N-[5-Methyl-1-[(1R,2R)-2-(prop-2-enoylamino)cyclohexyl]benzimidazol-2-yl]-3-(trifluoromethyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3981978; SCHEMBL16755399
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[27] | |||
| Compound Name |
2-Aminopyrido[2,3-d]pyrimidin-7(8H)-one 19
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL51573; BDBM3052; SCHEMBL5763098; 2,8-Dimethyl-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidine-7(8H)-one; 6-(2,6-dichlorophenyl)-2,8-dimethyl-7H,8H-pyrido[2,3-d]pyrimidin-7-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[26] | |||
| Compound Name |
4-(Bis(2-chloroethyl)amino)-N-dodecylbenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL590081; BDBM50308940
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[45] | |||
| Compound Name |
3-Substituted indolin-2-one 11d
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SU5402 analog 11d; BDBM4890; CHEMBL149243; SCHEMBL4416024; 3-[5-(6-Methoxy-2-oxo-1,2-dihydroindol-3-ylidenemethyl)-4-methyl-1H-pyrrol-3-yl]propionic Acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
2-(Cyclohexylamino)-6-(2,6-dichlorophenyl)-8-methylpyrido[2,3-d]pyrimidin-7-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-Cyclohexylamino-6-(2,6-dichlorophenyl)-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one; 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 25; BDBM3058; CHEMBL113128; SCHEMBL5764396; 2-(cyclohexylamino)-6-(2,6-dichlorophenyl)-8-methyl-7H,8H-pyrido[2,3-d]pyrimidin-7-one; 2-(Cyclohexylamino)-6-(2,6-dichlorophenyl)-8-methylpyrido[2,3-d]pyrimidine-7(8H)-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[21] | |||
| Compound Name |
4-[Phenyl(acetyl)amino]-5-anilinophthalimide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL268441; BDBM50040927; N-(1,3-Dioxo-6-phenylamino-2,3-dihydro-1H-isoindol-5-yl)-N-phenyl-acetamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[13] | |||
| Compound Name |
N-[5-Methyl-1-[4-(prop-2-enoylamino)phenyl]benzimidazol-2-yl]-3-(trifluoromethyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3916436; SCHEMBL16755410
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[27] | |||
| Compound Name |
4-N-(4-Chloro-2-fluorophenyl)-6-[(2-methylphenyl)methyl]-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1929552; BDBM50360174
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[49] | |||
| Compound Name |
3-[[5-Cyano-6-(cyclopentylamino)pyrimidin-4-yl]amino]-4-methyl-N-(1,2-oxazol-3-yl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
3-{[5-cyano-6-(cyclopentylamino)pyrimidin-4-yl]amino}-4-methyl-N-(1,2-oxazol-3-yl)benzamide; CHEMBL383172; 5-Cyanopyrimidine Derivative 3b; SCHEMBL16576397; BDBM16326; 3-{[5-cyano-6-(cyclopentylamino)pyrimidin-4-yl]amino}-N-isoxazol-3-yl-4-methylbenzamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[50] | |||
| Compound Name |
1-Butyl-1-(2-hydroxy-3,5-dimethylbenzyl)-3-phenylthiourea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL589365; BDBM50308634
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[32] | |||
| Compound Name |
5,6-Bis-(biphenyl-4-ylamino)-isoindole-1,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL7929; SCHEMBL8834140; BDBM50040919
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[13] | |||
| Compound Name |
Methyl-phenyl-(2,6,7-trimethoxy-quinazolin-4-yl)-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL135928; BDBM50291117
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[23] | |||
| Compound Name |
Cc1ccc2n(C3CN(C3)C(=O)C=C)c(NC(=O)c3cccc(c3)C(F)(F)F)nc2c1
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3921545; SCHEMBL16895919
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[27] | |||
| Compound Name |
N-[4-(4,5-Dichloro-2-fluoro-phenylamino)-quinazolin-6-yl]-2-methoxy-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL190651; SCHEMBL4586538; BDBM50171515; N-[4-(4,5-dichloro-2-fluoroanilino)quinazolin-6-yl]-2-methoxyacetamide; N-{4-[(4,5-dichloro-2-fluoro-phenyl)amino]quinazolin-6-yl}-2-methoxyacetamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 50000 nM
|
[51] | |||
| Compound Name |
4,5-Bis-(4-methoxyanilino)phthalimide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL7352; 5,6-bis(4-methoxyanilino)isoindole-1,3-dione; 4,5-Bis(4-methoxyanilino)phthalimide; 4,5-Bis[4-methoxyanilino]phthalimide; SCHEMBL5814108; BDBM50040925; 5,6-Bis-(4-methoxy-phenylamino)-isoindole-1,3-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[13] | |||
| Compound Name |
3-Substituted indolin-2-one 16e
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM4899; CHEMBL356245; SCHEMBL4411069
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
2-(6-((R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy)quinolin-3-yl)cyclopropanecarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL602472; BDBM50306684; CH-5234152
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[38] | |||
| Compound Name |
3-Substituted indolin-2-one 16c
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM4897; CHEMBL149073
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
4-(3,4-Dimethoxy-phenylsulfanyl)-6,7-dimethoxy-quinazoline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL132605; BDBM50291099
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[52] | |||
| Compound Name |
7-((1H-Imidazol-1-yl)methyl)-3-(thiophen-3-yl)-1,4-dihydroindeno[1,2-c]pyrazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL212084; SCHEMBL4817151; BDBM50188272; 7-(imidazol-1-ylmethyl)-3-thiophen-3-yl-1,4-dihydroindeno[1,2-c]pyrazole
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[41] | |||
| Compound Name |
3-Substituted indolin-2-one 11b
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SU5402 analog 11b; BDBM4888; CHEMBL435227; SCHEMBL4409949
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
5-[(1e)-2-(2-Methoxyphenyl)prop-1-En-1-Yl]furo[2,3-D]pyrimidine-2,4-Diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL610181; BDBM33394; 5-[(E)-2-(2-methoxyphenyl)prop-1-enyl]furo[2,3-d]pyrimidine-2,4-diamine; 2,4-diaminofuro[2,3-d]pyrimidine, 1a; Q27459028; Furo[2,3-d]pyrimidine-2,4-diamine, 5-[(1E)-2-(2-methoxyphenyl)-1-propenyl]-
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[53] | |||
| Compound Name |
N-Cyclopropyl-2,4-difluoro-5-((2-(pyridin-2-ylamino)thiazol-5-yl)methylamino)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BMS-605541; CHEMBL377734; BMS 605541; SCHEMBL2861987; BDBM50189603; AKOS034831603
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[54] | |||
| Compound Name |
N-[4-(3-Iodo-phenylamino)-quinazolin-6-yl]-2-methoxy-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL190567; SCHEMBL4587013; BDBM50171522; N-[4-(3-iodoanilino)quinazolin-6-yl]-2-methoxyacetamide; N-{4-[(3-iodophenyl)amino]-quinazolin-6-yl}-2-methoxyacetamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 50000 nM
|
[51] | |||
| Compound Name |
4,5-Bis[4-iodoanilino]phthalimide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL8163; SCHEMBL8834755; BDBM50040915; 5,6-bis(4-iodoanilino)isoindole-1,3-dione; 5,6-Bis-(4-iodo-phenylamino)-isoindole-1,3-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[13] | |||
| Compound Name |
(3Z)-6-(4-Hydroxy-3-methoxyphenyl)-3-(1H-imidazol-2-ylmethylidene)-2,3-dihydro-1H-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
indolinone analog 29; CHEMBL199299; BDBM14665
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[12] | |||
| Compound Name |
3-Substituted indolin-2-one 9b
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SU5402 analog 9b; BDBM4884; CHEMBL148744; SCHEMBL6393389
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
1-Butyl-1-(3,5-dibromo-2-hydroxybenzyl)-3-phenylurea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL590759; BDBM50308651
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[32] | |||
| Compound Name |
Methyl 3,10-dioxo-20-propoxy-12-oxapentacyclo[11.8.0.02,11.04,9.014,19]henicosa-1(13),2(11),4,6,8,14,16,18,20-nonaene-21-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL202216; BDBM50178496; 7,12-dioxo-5-propoxy-7,12-dihydro-dinaphtho[1,2-b;2'',3''-d]furan-6-carboxylic acid methyl ester
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[55] | |||
| Compound Name |
(2-Chloro-6,7-dimethoxy-quinazolin-4-yl)-methyl-phenyl-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL135417; BDBM50291108
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[23] | |||
| Compound Name |
1-[4-(4-Aminothieno[2,3-d]pyrimidin-5-yl)phenyl]-3-(3-methylphenyl)urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
GDP366; CHEMBL196363; Thienopyrimidine deriv. 76; Kinome_417; KDR Kinase Inhibitor, 1; SCHEMBL232042; BDBM8826; Biochemistry 469551 Compound 3; BCP30719; EX-A3218; HY-U00177; CS-7241; 3-(4-{4-aminothieno[2,3-d]pyrimidin-5-yl}phenyl)-1-(3-methylphenyl)urea; N-[4-(4-Aminothieno[2,3-d]pyrimidin-5-yl)phenyl]-N -(3-methylphenyl)urea; n-[4-(4-aminothieno[2,3-d]pyrimidin-5-yl)phenyl]-n'-(3-methylphenyl)urea
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[44] | |||
| Compound Name |
3-Substituted indolin-2-one 16b
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM4896; CHEMBL357803; SCHEMBL4410717
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Tert-Butyl-2-{5-(4-hydroxyphenethoxy)-1-{5-[4-(methylthio)phenyl]pentyl}-1H-indole-3-yl}ethyl carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1099339; BDBM50316778
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[34] | |||
| Compound Name |
N-[5-Methyl-1-[(1R,2S)-2-(prop-2-enoylamino)cyclohexyl]benzimidazol-2-yl]-3-(trifluoromethyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3961970; SCHEMBL16769988
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[27] | |||
| Compound Name |
[4-[(E)-2-Nitroethenyl]phenyl] 4-[[(2R)-1-[[(2R)-1-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethylamino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]carbamoyl]benzenesulfonate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL309073; BDBM50007065
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[56] | |||
| Compound Name |
N-[5-Methyl-1-(1-prop-2-enoylpiperidin-3-yl)benzimidazol-2-yl]-3-(trifluoromethyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3953921; SCHEMBL16895914; BDBM50196100
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[27] | |||
| Compound Name |
4-Fluoro-N-[3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL418279; SCHEMBL9565; BDBM50290412; 4-Fluoro-N-[3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
Chembl4284413
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
EAI001; 2-(1-oxoisoindolin-2-yl)-2-phenyl-N-(thiazol-2-yl)acetamide; SCHEMBL20365452; BDBM50468244; AKOS032960264; MCULE-8606894682; SR-01000077227; SR-01000077227-1; 2-(3-oxo-1H-isoindol-2-yl)-2-phenyl-N-(1,3-thiazol-2-yl)acetamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[57] | |||
| Compound Name |
(4-Chloro-phenyl)-(5,6-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL72560; SCHEMBL2458392; BDBM50051315; N-(4-chlorophenyl)-5,6-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[19] | |||
| Compound Name |
N-Methyl-N-phenylquinazolin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
4-Anilino quinazoline deriv. 11; BDBM3260; CHEMBL324371; SCHEMBL3109912
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[23] | |||
| Compound Name |
Cc1ccc2n(C3CCCN(CC3)C(=O)C=C)c(NC(=O)c3cccc(c3)C(F)(F)F)nc2c1
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3972987; SCHEMBL16895628
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[27] | |||
| Compound Name |
Flavopiridol analogue 18
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM5711; CHEMBL133498; SCHEMBL8681420; 2-(2-chlorophenoxy)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]-4H-chromen-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[46] | |||
| Compound Name |
Cc1ccc2n(C3CCN(C3)C(=O)C=C)c(NC(=O)c3cccc(c3)C(F)(F)F)nc2c1
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3894391; SCHEMBL16895638
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[27] | |||
| Compound Name |
N-[5-Methyl-1-[2-(prop-2-enoylamino)ethyl]benzimidazol-2-yl]-3-(trifluoromethyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3936272; SCHEMBL16755426
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[27] | |||
| Compound Name |
N-[1-(4-Hydroxycyclohexyl)benzimidazol-2-yl]-3-(trifluoromethyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3954370; BDBM50196105
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[27] | |||
| Compound Name |
4-(3,4-Dimethoxyanilino)-6,7-dimethoxyquinoline-3-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
4-[(3,4-dimethoxyphenyl)amino]-6,7-dimethoxyquinoline-3-carbonitrile; 6,7-dialkoxyquinoline-3-carbonitrile deriv. 11; CHEMBL83228; BDBM4448; SCHEMBL6380423; HMS3487A16; ZINC3832365; 4-Anilino-3-cyanoquinoline deriv. 7e; 4-(3,4-Dimethoxyphenylamino)-6,7-dimethoxyquinoline-3-carbonitrile; 4-[(3,4-dimethoxyphenyl)amino]-6,7-dimethoxy-3-quinolinecarbonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 = 50118.72 nM
|
[58] | |||
| Compound Name |
1 H-Indole-3-alkanamide deriv. 10p
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM4007; CHEMBL346716
Click to Show/Hide
|
||||
| Activity |
IC50 = 51000 nM
|
[59] | |||
| Compound Name |
Chembl4246256
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50462072
Click to Show/Hide
|
||||
| Activity |
IC50 = 52110 nM
|
[60] | |||
| Compound Name |
Dithiobis(1H-indole-3-alkanoic acid) deriv. 21
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL84141; BDBM3972; 2,2 -Dithiobis(1-methyl-1H-indole-3-acetic acid); 2,2'-Dithiobis(1-methyl-1H-indole-3-acetic acid); 2-(2-{[3-(carboxymethyl)-1-methyl-1H-indol-2-yl]disulfanyl}-1-methyl-1H-indol-3-yl)acetic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 53000 nM
|
[61] | |||
| Compound Name |
2-Amino-4-(N-methyl-m-bromoanilino)-6-benzyl-pyrrolo[2,3-d]pyrimidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1254199; BDBM50326609
Click to Show/Hide
|
||||
| Activity |
IC50 = 53100 nM
|
[62] | |||
| Compound Name |
N-[4-[4-(Diaminomethylideneamino)sulfonylanilino]quinazolin-6-yl]prop-2-enamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3133911
Click to Show/Hide
|
||||
| Activity |
IC50 = 53300 nM
|
[63] | |||
| Compound Name |
N-[4-(2,4-Dimethoxyanilino)quinazoline-6-yl]acrylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3133906
Click to Show/Hide
|
||||
| Activity |
IC50 = 53600 nM
|
[63] | |||
| Compound Name |
2-[5-(2,2-Dicyanoethenyl)-2-hydroxy-3-methoxyphenyl]sulfanylacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1161236; BDBM50409737
Click to Show/Hide
|
||||
| Activity |
IC50 = 53703.18 nM
|
[64] | |||
| Compound Name |
Dithiobis(1H-indole-3-carboxamide) deriv. 10n
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM4029; CHEMBL291979; SCHEMBL8998882; N,N'-Diphenyl[2,2'-dithiobis(5-cyano-1-methyl-1H-indole-3-carboxamide)]
Click to Show/Hide
|
||||
| Activity |
IC50 = 54100 nM
|
[65] | |||
| Compound Name |
3-(3-Ethoxy-4-methoxyphenyl)-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242752
Click to Show/Hide
|
||||
| Activity |
IC50 = 54200 nM
|
[43] | |||
| Compound Name |
(E)-3-(3,4-Dihydroxyphenyl)-2-(4-phenylpiperazine-1-carbonyl)prop-2-enenitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Tyrphostin deriv. 68; BDBM4315; CHEMBL291986; 3-(3,4-Dihydroxyphenyl)-2-[(4-phenyl-1-piperazinyl)carbonyl]acrylonitrile; (2E)-3-(3,4-dihydroxyphenyl)-2-[(4-phenylpiperazin-1-yl)carbonyl]prop-2-enenitrile
Click to Show/Hide
|
||||
| Activity |
IC50 = 55000 nM
|
[66] | |||
| Compound Name |
(E)-2-Cyano-3-(3,5-dibutyl-4-hydroxyphenyl)prop-2-enamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL77243
Click to Show/Hide
|
||||
| Activity |
IC50 = 55000 nM
|
[30] | |||
| Compound Name |
Malononitrile, (5-nitrovanillylidene)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-[(4-hydroxy-3-methoxy-5-nitrophenyl)methylidene]propanedinitrile; 5-Nitrovanillylidenemalononitrile; Propanedinitrile,2-[(4-hydroxy-3-methoxy-5-nitrophenyl)methylene]-; ACMC-20m4rr; Oprea1_087808; Oprea1_786471; BDBM4333; CHEMBL307179; CTK4A0198; DTXSID90144169; MCK100760; AKOS002952032; MCULE-1517042950; benzylidenemalononitrile (BMN) deriv. 17; SR-01000203377; SR-01000203377-1
Click to Show/Hide
|
||||
| Activity |
Ki = 55000 nM
|
[30] | |||
| Compound Name |
6-[(2,4-Dichlorophenyl)methyl]-4-N-(3-ethynylphenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1094475; BDBM50318178; N4-(3-Ethynylphenyl)-6-(2,4-dichlorobenzyl)-7Hpyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
||||
| Activity |
IC50 = 55200 nM
|
[67] | |||
| Compound Name |
2-(2-Imino-4-phenyl-1,3-thiazol-3-yl)-1-morpholin-4-ylethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2437301; BDBM50441919
Click to Show/Hide
|
||||
| Activity |
Ki = 55290 nM
|
[68] | |||
| Compound Name |
N-(1-(3-Bromophenylamino)-4-cyanoisoquinolin-7-yl)furan-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1641996; BDBM50334220
Click to Show/Hide
|
||||
| Activity |
IC50 = 55600 nM
|
[69] | |||
| Compound Name |
N-1H-Indol-5-yl-6-(2-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1097368; BDBM50318168
Click to Show/Hide
|
||||
| Activity |
IC50 = 56100 nM
|
[70] | |||
| Compound Name |
2,4-Diaminofuro[2,3-d]pyrimidine, 10
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL603198; BDBM33404; D2E
Click to Show/Hide
|
||||
| Activity |
IC50 = 56500 nM
|
[53] | |||
| Compound Name |
Indolin-2-one deriv. 9d
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM4917; CHEMBL431996; 2-(5-Carboxy-2-oxo-3-indolinylidenemethyl)-4,5,6,7-tetrahydro-1H-indole-3-propionic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 56500 nM
|
[15] | |||
| Compound Name |
N-(3-Acetylphenyl)-1H-indole-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3800262; ZINC8076710; BDBM50165847; AKOS008920869; MCULE-5855200375; Z30815669
Click to Show/Hide
|
||||
| Activity |
IC50 = 57000 nM
|
[39] | |||
| Compound Name |
Azobenzene-2,4,4'-triol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL47966; BDBM50407165
Click to Show/Hide
|
||||
| Activity |
IC50 = 58000 nM
|
[9] | |||
| Compound Name |
N-(5-{[5-Chloro-4-(1-methylindol-3-yl)pyrimidin-2-yl]amino}-2-{2-dimethylaminoethyl-methylamino}-4-methoxyphenyl)prop-2-enamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3353407; SCHEMBL14661147; BDBM50029661
Click to Show/Hide
|
||||
| Activity |
IC50 = 58000 nM
|
[71] | |||
| Compound Name |
N-[5-Chloro-4-(4-chloroanilino)-9H-pyrimido[4,5-b]indol-2-yl]-2,2-dimethylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2337369; BDBM50430564
Click to Show/Hide
|
||||
| Activity |
IC50 = 58700 nM
|
[8] | |||
| Compound Name |
3'-Chloro-7-hydroxyisoflavone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL7699; CTK0J6388; DTXSID50441843; BDBM50074748; ZINC13795469; 3-(3-Chloro-phenyl)-7-hydroxy-chromen-4-one; 4H-1-Benzopyran-4-one, 3-(3-chlorophenyl)-7-hydroxy-
Click to Show/Hide
|
||||
| Activity |
IC50 = 58800 nM
|
[72] | |||
| Compound Name |
5,21-Dihydroxy-13-(propylamino)-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL21096; BDBM50076936
Click to Show/Hide
|
||||
| Activity |
IC50 = 59000 nM
|
[73] | |||
| Compound Name |
2-[5-[(2,5-Dihydroxyphenyl)methylideneamino]-2-hydroxyphenyl]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL171000; BDBM50453598
Click to Show/Hide
|
||||
| Activity |
IC50 = 60000 nM
|
[33] | |||
| Compound Name |
4-[5-(2-Carbamoyl-2-cyano-vinyl)-2-hydroxy-3-methoxy-benzylsulfanyl]-butyric acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL326044; BDBM50036704
Click to Show/Hide
|
||||
| Activity |
IC50 = 60000 nM
|
[36] | |||
| Compound Name |
2-[(4-Formylphenyl)methylidene]propanedinitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
benzylidenemalononitrile (BMN) deriv. 21; BDBM4337; CHEMBL311119; SCHEMBL6281339; (4-Formylbenzylidene)malononitrile; 4-(2,2-dicyanoethenyl)benzaldehyde; Propanedinitrile, 2-[(4-formylphenyl)methylene]-
Click to Show/Hide
|
||||
| Activity |
IC50 = 60000 nM
|
[30] | |||
| Compound Name |
(3Z)-2-Amino-4-(4-hydroxy-3-nitrophenyl)buta-1,3-diene-1,1,3-tricarbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL309625
Click to Show/Hide
|
||||
| Activity |
IC50 = 60000 nM
|
[30] | |||
| Compound Name |
(3Z)-2-Amino-4-(1H-indol-5-yl)buta-1,3-diene-1,1,3-tricarbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
AG-370; NSC651712; TYRPHOSTIN B7; BiomolKI_000027; BiomolKI2_000035; BMK1-D3; BSPBio_001394; CHEMBL59150; BCBcMAP01_000042; HMS1361F16; HMS1362L15; HMS1791F16; HMS1792L15; HMS1989F16; HMS1990L15; HMS3402F16; MFCD00236449; ZINC18128115; CCG-100631; NSC-651712; IDI1_002192; IDI1_033864; NCGC00163377-01; NCGC00163377-02; NCGC00163377-03; J-006473; BRD-K33204703-001-04-6; 2-Amino-4-(1H-indol-5-yl)-1,3-butadiene-1,1,3-tricarbonitrile; (3Z)-2-Amino-4-(1H-indol-5-yl)-1,3-butadiene-1,1,3-tricarbonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[66] | |||
| Compound Name |
Tyrphostin deriv. 21
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL56964; BDBM4290; (5-Methoxy-6-hydroxy-2-oxo-3-indolinidene)malononitrile; [(2,3-Dihydro-6-hydroxy-5-methoxy-2-oxo-1H-indol)-3-ylidene]malononitrile; 2-(6-hydroxy-5-methoxy-2-oxo-2,3-dihydro-1H-indol-3-ylidene)propanedinitrile
Click to Show/Hide
|
||||
| Activity |
IC50 = 60000 nM
|
[66] | |||
| Compound Name |
2-(1H-Benzimidazol-2-ylmethyl)-5-(2,3-dimethoxyphenyl)-1,3,4-oxadiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4065301; BDBM50232341
Click to Show/Hide
|
||||
| Activity |
IC50 = 60953.69 nM
|
[47] | |||
| Compound Name |
2-Chloro-6,7-dimethoxy-N-(4-(methylsulfonyl)phenyl)quinazolin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3098315; BDBM50444628; ZINC103226716; DA-26425; FT-0723401; 2-chloro-6,7-dimethoxy-N-(4-methylsulfonylphenyl)quinazolin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 61500 nM
|
[74] | |||
| Compound Name |
6,7-Dialkoxyquinoline-3-carbonitrile deriv. 33
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM4470; CHEMBL109625; 4-(3-Isopropylphenylamino)-6,7-dimethoxyquinoline-3-carbonitrile; 6,7-dimethoxy-4-{[3-(propan-2-yl)phenyl]amino}quinoline-3-carbonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 = 61659.5 nM
|
[58] | |||
| Compound Name |
2-(3,4-Dihydroxy-5-methylbenzylidene)malononitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL116423; SCHEMBL10186359; CTK8H0386; BDBM50036684; 2-(3,4-Dihydroxy-5-methyl-benzylidene)-malononitrile; 2-[3-Methyl-4,5-dihydroxybenzylidene]propanedinitrile
Click to Show/Hide
|
||||
| Activity |
IC50 = 61659.5 nM
|
[64] | |||
| Compound Name |
N-(3-Chloro-2-fluorophenyl)-8,9-dimethoxy-5,6-dihydropyrimido[4,5-b][1,4]benzothiazepin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL214999; BDBM50192482
Click to Show/Hide
|
||||
| Activity |
IC50 = 62900 nM
|
[75] | |||
| Compound Name |
N'-(4-Chlorophenyl)-5-chloro-9H-pyrimido[4,5-b]indole-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2337363; BDBM50430570
Click to Show/Hide
|
||||
| Activity |
IC50 = 63600 nM
|
[8] | |||
| Compound Name |
4-N-(4-Nitrophenyl)pyrido[4,3-d]pyrimidine-4,7-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
7-Aminopyrido[4,3-d]pyrimidine 7d; BDBM3307; CHEMBL333115; ZINC13743442; N-(4-Nitrophenyl)pyrido[4,3-d]pyrimidine-4,7-diamine; 7-Amino-4-[(4-nitrophenyl)amino]pyrido[4,3-d]pyrimidine
Click to Show/Hide
|
||||
| Activity |
IC50 = 65000 nM
|
[76] | |||
| Compound Name |
N-[4-Methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CGP-53716; CGP53716;CGP 53716; CHEMBL20926; cgp53716; SCHEMBL9782; BCP34642; BDBM50240407; MFCD00945675; VCC347042; AK688902; BS-15548; N-(4-Methyl-3(4-(pyridine-3-yl)pyrimidin-2-ylamino)phenyl)benzamide; N-(4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)benzamide; N-[4-Methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 65000 nM
|
[2] | |||
| Compound Name |
8-(Benzylamino)-1-(3-morpholin-4-ylpropyl)-[1,3]oxazolo[4,5-g]quinazolin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064400; BDBM50389376
Click to Show/Hide
|
||||
| Activity |
IC50 = 65000 nM
|
[77] | |||
| Compound Name |
1-[2-[5-(1H-Benzimidazol-2-ylmethyl)-1,3,4-oxadiazol-2-yl]phenyl]ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4068814; BDBM50232336
Click to Show/Hide
|
||||
| Activity |
IC50 = 65400 nM
|
[47] | |||
| Compound Name |
2-[[5,13-Diamino-11-(2-hydroxyethylamino)-4-thia-8,10,12-triazatricyclo[7.4.0.02,6]trideca-1(13),2,5,7,9,11-hexaen-7-yl]amino]ethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910278; BDBM50356624
Click to Show/Hide
|
||||
| Activity |
IC50 = 66100 nM
|
[78] | |||
| Compound Name |
2-[(4-Hydroxy-3-methoxyphenyl)methylidene]propanedinitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
(4-Hydroxy-3-methoxybenzylidene)malononitrile; Malononitrile, vanillylidene-; (4-hydroxy-3-methoxybenzylidene)propanedinitrile; 2-(4-Hydroxy-3-methoxybenzylidene)malononitrile; NSC 61936; TX 1121; Vanillylidenemalononitrile; 2-[(4-hydroxy-3-methoxyphenyl)methylene]malononitrile; MALONONITRILE, (4-HYDROXY-3-METHOXYBENZYLIDENE)-; ((4-HYDROXY-3-METHOXYPHENYL)METHYLENE)METHANE-1,1-DICARBONITRILE; Vanillylidenemalononitrile; F 2373; NSC 61936; TX 1121; BRN 2695114; 3-Methoxy-4-hydroxy-benzal-malonitril [German]; Oprea1_430831; Oprea1_690178; CHEMBL77869; BDBM4332; SCHEMBL8743696; CTK7C4389; DTXSID80190453; Propanedinitrile, ((4-hydroxy-3-methoxyphenyl)methylene)-; HMS1578O02; Propanedinitrile, 2-[(4-hydroxy-3-methoxyphenyl)methylene]-; ZINC156100; KS-000028LI; NSC61936; BBL008142; MCK103594; MFCD00137632; NSC-61936; STK414180; 3-Methoxy-4-hydroxy-benzal-malonitril; AKOS002161458; MCULE-9571387119; MS-6397; benzylidenemalononitrile (BMN) deriv. 16; 3-Methoxy-4-hydroxybenzylidenemalononitrile; T8405; 2-(4-hydroxy-3-methoxybenzylidene) malononitrile; 2-10-00-00393 (Beilstein Handbook Reference); F6782-3630
Click to Show/Hide
|
||||
| Activity |
Ki = 67000 nM
|
[30] | |||
| Compound Name |
4-[(2-Chloro-6,7-dimethoxyquinazolin-4-yl)amino]-N,N-dimethylbenzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3098312; BDBM50444627
Click to Show/Hide
|
||||
| Activity |
IC50 = 67200 nM
|
[74] | |||
| Compound Name |
1 H-Indole-3-alkanamide deriv. 10g
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM3998; CHEMBL154969; 2,2'-Dithiobis(N-methoxy-1H-indole-3-propanamide); N-methoxy-3-[2-({3-[2-(methoxycarbamoyl)ethyl]-1H-indol-2-yl}disulfanyl)-1H-indol-3-yl]propanamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 68000 nM
|
[59] | |||
| Compound Name |
4-N-[2-(Dimethylamino)phenyl]pyrido[4,3-d]pyrimidine-4,7-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
7-Aminopyrido[4,3-d]pyrimidine 7q; BDBM3320; CHEMBL123523; ZINC13743449; N-(2-Dimethylaminophenyl)pyrido[4,3-d]pyrimidine-4,7-diamine; 7-amino-4-[[2-(dimethylamino)phenyl]amino]pyrido[4,3-d]pyrimidine
Click to Show/Hide
|
||||
| Activity |
IC50 = 69000 nM
|
[76] | |||
| Compound Name |
N-[3-[(3-Cyano-6,7-dimethoxyquinolin-4-yl)amino]phenyl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
N-{3-[(3-cyano-6,7-dimethoxyquinolin-4-yl)amino]phenyl}acetamide; 6,7-dialkoxyquinoline-3-carbonitrile deriv. 40; BDBM4477; CHEMBL324399; SCHEMBL6382170; 4-(3-Acetamidophenylamino)-6,7-dimethoxy-3-quinolinecarbonitrile; N-[3-(3-Cyano-6,7-dimethoxyquinolin-4-ylamino)phenyl]acetamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 69183.1 nM
|
[58] | |||
| Compound Name |
4-N-(3-Bromophenyl)-7-[(2,5-dimethoxyphenyl)methyl]pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956892; BDBM50366091
Click to Show/Hide
|
||||
| Activity |
IC50 = 69200 nM
|
[25] | |||
| Compound Name |
4-Amino-2-[5-(1H-benzimidazol-2-ylmethyl)-1,3,4-oxadiazol-2-yl]phenol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4094647; BDBM50232337
Click to Show/Hide
|
||||
| Activity |
IC50 = 69984.2 nM
|
[47] | |||
| Compound Name |
1-Isopropyl-3-(pyrido[3,2-b]pyrazin-7-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1241775
Click to Show/Hide
|
||||
| Activity |
IC50 = 70000 nM
|
[43] | |||
| Compound Name |
2-[[3-(Diethoxyphosphorylmethyl)-4-hydroxyanilino]methyl]benzene-1,4-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL355419; BDBM50453579
Click to Show/Hide
|
||||
| Activity |
IC50 = 70000 nM
|
[33] | |||
| Compound Name |
2-Cyano-2-(3,4-dihydroxy-benzyl)-thioacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL78249; TRYPHOSTIN; BDBM50031654
Click to Show/Hide
|
||||
| Activity |
IC50 = 70000 nM
|
[79] | |||
| Compound Name |
N-[(2R,3S,4S,6S)-3-Methoxy-2-methyl-16-oxo-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-4-yl]-N-methyl-3,5-dinitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL132170; BDBM50283880
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 70000 nM
|
[80] | |||
| Compound Name |
(E)-2-Cyano-3-(3,4-dihydroxyphenyl)-2-propenoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
AG 30; Tyrphostin AG 30; Tyrphostin AG30; AG-30; (E)-2-cyano-3-(3,4-dihydroxyphenyl)acrylic acid; alpha-Cyano-(3,4-dihydroxy)cinnamic acid; 2-Propenoic acid, 2-cyano-3-(3,4-dihydroxyphenyl)-, (E)-; Tyrphostin AG-30; Tyrphostin AG-43; Tyrophostin AG 30; (E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enoic acid; alpha-Cyano-3,4-dihydroxycinnamic acid; (2E)-2-CYANO-3-(3,4-DIHYDROXYPHENYL)ACRYLIC ACID; CHEMBL73820; BDBM4352; ZINC3871432; 2-Propenoic acid, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)- (9CI); HSCI1_000132; MFCD09739079; AKOS000146224; benzylidenemalononitrile (BMN) deriv. 36; BS-15011; HY-118532; CS-0066283; 520C790; J-004814; (2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enoic acid; 2-propenoic acid, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)-
Click to Show/Hide
|
||||
| Activity |
Ki = 70000 nM
|
[30] | |||
| Compound Name |
6,7-Dimethoxyisoquinoline-4-carbonitrile deriv. 61
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM4490; CHEMBL324439; 1-(3-Bromophenylamino)-6,7-dimethoxyisoquinoline-4-carbonitrile; 1-[(3-bromophenyl)amino]-6,7-dimethoxyisoquinoline-4-carbonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 = 70794.58 nM
|
[58] | |||
| Compound Name |
N-(2-{2-Dimethylaminoethyl-methylamino}-4-methoxy-5-{[5-methyl-4-(1-methylindol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3353409; SCHEMBL14719501; BDBM50029688
Click to Show/Hide
|
||||
| Activity |
IC50 = 71000 nM
|
[71] | |||
| Compound Name |
(Z)-3-(4-Hydroxyphenyl)-2-pyridin-2-ylprop-2-enenitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL43689; ZINC4347852; BDBM50409195; AKOS001301581; AB00757746-01
Click to Show/Hide
|
||||
| Activity |
IC50 = 71700 nM
|
[81] | |||
| Compound Name |
N-[1-(2-Chloro-6-fluorobenzyl)-1H-pyrazol-3-yl]-1,3-dimethyl-1H-pyrazole-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2029697; ZINC2768934; BDBM50384138; STK317459; ZINC02768934; AKOS003757376; MCULE-1102564344; AK-968/41022843
Click to Show/Hide
|
||||
| Activity |
IC50 = 72400 nM
|
[82] | |||
| Compound Name |
2-(1H-Benzimidazol-2-ylmethyl)-5-pyridin-2-yl-1,3,4-oxadiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4074726; BDBM50232345
Click to Show/Hide
|
||||
| Activity |
IC50 = 73451.39 nM
|
[47] | |||
| Compound Name |
(4E)-1-(3,4-Dimethylphenyl)-4-[[5-(2-hydroxy-5-nitrophenyl)furan-2-yl]methylidene]pyrazolidine-3,5-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2029690; BDBM50384131; ZINC33290941
Click to Show/Hide
|
||||
| Activity |
IC50 = 74300 nM
|
[82] | |||
| Compound Name |
3-[3-(1H-Benzoimidazol-2-ylsulfanylmethyl)-4-hydroxy-5-methoxy-phenyl]-2-cyano-acrylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL331026; BDBM50036697; (E)-3-[3-(1H-Benzoimidazol-2-ylsulfanylmethyl)-4-hydroxy-5-methoxy-phenyl]-2-cyano-acrylamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 75000 nM
|
[36] | |||
| Compound Name |
7,8-Dimethoxy-5,10-dihydro-1H-pyrimido[4,5-b]quinolin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL414013; SCHEMBL8357530; BDBM50132155; 7,8-Dimethoxy-5,10-dihydro-3H-pyrimido[4,5-b]quinolin-4-one; 7,8-dimethoxy4-oxo-3,4,5,10-tetrahydropyrimido[4,5-b]quinoline
Click to Show/Hide
|
||||
| Activity |
IC50 = 75000 nM
|
[83] | |||
| Compound Name |
N-Benzoyl-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL277430; BDBM50287092
Click to Show/Hide
|
||||
| Activity |
IC50 = 75000 nM
|
[84] | |||
| Compound Name |
8-(3,5-Dimethylanilino)-1-(3-morpholin-4-ylpropyl)-[1,3]oxazolo[4,5-g]quinazolin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064379; BDBM50389359
Click to Show/Hide
|
||||
| Activity |
IC50 = 75000 nM
|
[77] | |||
| Compound Name |
Dimeric Tyrphostin 24
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM5166; CHEMBL342792
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 75000 nM
|
[85] | |||
| Compound Name |
2-[[3-(Diethoxyphosphorylmethyl)-4-hydroxyphenyl]iminomethyl]benzene-1,4-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL354757; BDBM50453591
Click to Show/Hide
|
||||
| Activity |
IC50 = 75000 nM
|
[33] | |||
| Compound Name |
2-(6-Amino-9H-purine-9-yl)-1-phenylethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL520515; BDBM50268225; AKOS011299819
Click to Show/Hide
|
||||
| Activity |
IC50 = 75000 nM
|
[86] | |||
| Compound Name |
Benzylidenemalononitrile (BMN) deriv. 65
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL76642; BDBM4380; SCHEMBL8749032; 2,5-Dihydroxy-alpha-cyano-cis-cinnamic acid; (2Z)-2-cyano-3-(2,5-dihydroxyphenyl)prop-2-enoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 75000 nM
|
[30] | |||
| Compound Name |
(2-Chloro-phenyl)-(5,6-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL73625; SCHEMBL2461532; BDBM50051299; N-(2-chlorophenyl)-5,6-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 75100 nM
|
[19] | |||
| Compound Name |
4-Hydroxy-8-methoxy-6-methyl-2H-pyrano[3,2-c]quinoline-2,5(6H)-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1944928; SCHEMBL13440771; ZINC6557199; BDBM50363484; MCULE-4168902423; AE-406/41057170
Click to Show/Hide
|
||||
| Activity |
IC50 = 76400 nM
|
[87] | |||
| Compound Name |
N-[4-(4-Sulfamoylanilino)quinazolin-6-yl]prop-2-enamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3133910
Click to Show/Hide
|
||||
| Activity |
IC50 = 76500 nM
|
[63] | |||
| Compound Name |
5-[(1E)-2-(5,6-Dibromo-3-ethoxy-2-hydroxyphenyl)-1-azavinyl]-3-hydrobenzimidaz ol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3335245; Oprea1_030343; Oprea1_495189; ZINC868331; BDBM50026038; AKOS024361565; MCULE-8743433907; ST50992035
Click to Show/Hide
|
||||
| Activity |
IC50 = 76700 nM
|
[88] | |||
| Compound Name |
7-(3-Chloro-4-(3-fluorobenzyloxy)phenylamino)-N-(2-(diethylamino)ethyl)-1H-pyrrolo[2,3-d]pyridazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1080271; BDBM50311468
Click to Show/Hide
|
||||
| Activity |
IC50 = 77220 nM
|
[89] | |||
| Compound Name |
(5,6-Dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-(4-ethyl-phenyl)-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL309937; SCHEMBL2458457; BDBM50051301; N-(4-ethylphenyl)-5,6-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 77500 nM
|
[19] | |||
| Compound Name |
3-[5-(2-Chlorophenyl)-1,3,4-thiadiazol-2-yl]-2-phenylquinazolin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4083815; BDBM50245699
Click to Show/Hide
|
||||
| Activity |
IC50 = 78230 nM
|
[90] | |||
| Compound Name |
8-(4-Tert-butylanilino)-1-(3-morpholin-4-ylpropyl)-[1,3]oxazolo[4,5-g]quinazolin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064396; BDBM50389373
Click to Show/Hide
|
||||
| Activity |
IC50 = 79000 nM
|
[77] | |||
| Compound Name |
Dimeric Tyrphostin 11
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM5158; CHEMBL145266
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 80000 nM
|
[85] | |||
| Compound Name |
(3,4-Dimethoxy-phenyl)-(6,7-dimethoxy-quinolin-4-yl)-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL98137; BDBM50290849; MCULE-6650187798
Click to Show/Hide
|
||||
| Activity |
IC50 = 80500 nM
|
[18] | |||
| Compound Name |
3-(3-Chlorophenyl)-5-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-phenyl-3,4-dihydropyrazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3805409; BDBM50172060
Click to Show/Hide
|
||||
| Activity |
IC50 = 81200 nM
|
[91] | |||
| Compound Name |
2-[5,6-Dimethyl-3-(4-methylphenyl)-4-oxo(3-hydrothiopheno[2,3-d]pyrimidin-2-yl thio)]-N-(2-chlorophenyl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1944641; ZINC8446119; BDBM50363486; AKOS000586432; MCULE-4026341518; ST50261149; AG-690/40751723
Click to Show/Hide
|
||||
| Activity |
IC50 = 81600 nM
|
[87] | |||
| Compound Name |
2-(6-Amino-7H-purine-7-yl)-1-(1H-indole-3-yl)ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL485246; BDBM50268224
Click to Show/Hide
|
||||
| Activity |
IC50 = 82000 nM
|
[86] | |||
| Compound Name |
5-Chloro-4-N-(3-methoxyphenyl)-9H-pyrimido[4,5-b]indole-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2337366; BDBM50430567
Click to Show/Hide
|
||||
| Activity |
IC50 = 82900 nM
|
[8] | |||
| Compound Name |
(E)-2-Cyano-N-[[4-[(E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enoyl]piperazin-1-yl]methyl]-3-(3,4-dihydroxyphenyl)prop-2-enamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
NSC677215; CHEMBL145209; NSC-677215
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 83000 nM
|
[85] | |||
| Compound Name |
3-[3-(5-Chloro-benzothiazol-2-ylsulfanylmethyl)-4-hydroxy-5-methoxy-phenyl]-2-cyano-acrylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL115519; BDBM50036683; (E)-3-[3-(5-Chloro-benzothiazol-2-ylsulfanylmethyl)-4-hydroxy-5-methoxy-phenyl]-2-cyano-acrylamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 83000 nM
|
[36] | |||
| Compound Name |
(E)-2-Cyano-N-[4-[[4-[[(E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enoyl]amino]cyclohexyl]methyl]cyclohexyl]-3-(3,4-dihydroxyphenyl)prop-2-enamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
NSC653260; CHEMBL147880; HSCI1_000155; NSC-653260; BRD-K89930444-001-01-9; N,N'-[Methylenebis(cyclohexane-4,1-diyl)]bis[(E)-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide]
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 83000 nM
|
[85] | |||
| Compound Name |
1,3-Dimethyl-6-{[3-(trifluoromethyl)benzyl]amino}-2,4(1H,3H)-pyrimidinedione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2029695; ZINC6219239; BDBM50384136; MCULE-3680009884; AI-204/31699028
Click to Show/Hide
|
||||
| Activity |
IC50 = 83900 nM
|
[82] | |||
| Compound Name |
2-[4-Hydroxy-3-methoxy-5-(toluene-4-sulfonylmethyl)-benzylidene]-malononitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL334032; BDBM50036696; 2-[3-[[(4-Methylphenyl)sulfonyl]methyl]-4-hydroxy-5-methoxybenzylidene]propanedinitrile
Click to Show/Hide
|
||||
| Activity |
IC50 = 85000 nM
|
[36] | |||
| Compound Name |
7-Phenyl-10-sulfanyl-6,12-dihydrobenzo[h][1,2,4]triazolo[4',3':1,2]pyrimido[4,5-b]quinolin-8(5H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1944930; BDBM50363487; ZINC17117759; MCULE-8111694008; AI-060/43371931
Click to Show/Hide
|
||||
| Activity |
IC50 = 85600 nM
|
[87] | |||
| Compound Name |
4-N-(3-Bromo-4-fluorophenyl)-6-(2-pyridin-2-ylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2335377; BDBM50429674
Click to Show/Hide
|
||||
| Activity |
IC50 = 85900 nM
|
[92] | |||
| Compound Name |
2-(2,7a-Dihydro-1H-indol-3-ylmethyl)-5-(1H-benzimidazol-2-ylmethyl)-1,3,4-oxadiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4087489; BDBM50232339
Click to Show/Hide
|
||||
| Activity |
IC50 = 86200 nM
|
[47] | |||
| Compound Name |
2-[3-Methyl-4-hydroxy-5-methoxybenzylidene]propanedinitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL120564; BDBM50036699; 2-(4-Hydroxy-3-methoxy-5-methyl-benzylidene)-malononitrile
Click to Show/Hide
|
||||
| Activity |
IC50 = 87000 nM
|
[36] | |||
| Compound Name |
5-[(1E)-2-(5,6-Dibromo-2-hydroxy-3-methoxyphenyl)-1-azavinyl]-3-hydrobenzimida zol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3335244; Oprea1_441164; Oprea1_611703; ZINC3148634; BDBM50026039; AKOS024352751; MCULE-4354812735; ST50978263
Click to Show/Hide
|
||||
| Activity |
IC50 = 88670 nM
|
[88] | |||
| Compound Name |
3-(2-Nitroethyl)-2-[[3-(2-nitroethyl)-1H-indol-2-yl]disulfanyl]-1H-indole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
3-(2-nitroethyl)-2-{[3-(2-nitroethyl)-1H-indol-2-yl]disulfanyl}-1H-indole; 1 H-indole-3-alkanamide deriv. 10d; BDBM3995; CHEMBL158119; SCHEMBL8999091
Click to Show/Hide
|
||||
| Activity |
IC50 = 89000 nM
|
[59] | |||
| Compound Name |
2-(6-Amino-9H-purin-9-yl)-1-(pyridin-2-yl)ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL504135; BDBM50268226; 2-(6-Amino-9H-purine-9-yl)-1-(pyridine-2-yl)ethanone
Click to Show/Hide
|
||||
| Activity |
IC50 = 89000 nM
|
[86] | |||
| Compound Name |
6,7-Dimethoxyisoquinoline-4-carbonitrile deriv. 62
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM4491; CHEMBL109259; 1-(3-Chlorophenylamino)-6,7-dimethoxyisoquinoline-4-carbonitrile; 1-[(3-chlorophenyl)amino]-6,7-dimethoxyisoquinoline-4-carbonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 = 89125.09 nM
|
[58] | |||
| Compound Name |
5,21-Dihydroxy-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL21108; BDBM50073855
Click to Show/Hide
|
||||
| Activity |
IC50 = 90000 nM
|
[73] | |||
| Compound Name |
4-[[5,21-Dihydroxy-12,14-dioxo-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaen-13-yl]amino]benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL279035; BDBM50076944
Click to Show/Hide
|
||||
| Activity |
IC50 = 90000 nM
|
[73] | |||
| Compound Name |
4-Dimethylamino-but-2-ynoic acid [4-(3-bromo-phenylamino)-3-cyano-7-methoxy-quinolin-6-yl]-amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL116853; SCHEMBL8150506; BDBM50122578
Click to Show/Hide
|
||||
| Activity |
IC50 = 90011.91 nM
|
[93] | |||
| Compound Name |
N-[2-(2-Methoxyanilino)-4-pyrimidinyl]-N-(2-methoxyphenyl)amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1947046; BDBM50363475; AP-501/43295688
Click to Show/Hide
|
||||
| Activity |
IC50 = 90400 nM
|
[87] | |||
| Compound Name |
N4-(3-Fluoro-4-trifluoromethylphenyl)-6-(2,4-dichlorobenzyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1094808; BDBM50318179
Click to Show/Hide
|
||||
| Activity |
IC50 = 91700 nM
|
[67] | |||
| Compound Name |
Lavendustin c
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Compound 5; UNII-HJM06BIW5M; 5-(2,5-Dihydroxybenzylamino)-2-hydroxybenzoic acid; 5-((2,5-Dihydroxybenzyl)amino)-2-hydroxybenzoic acid; HJM06BIW5M; CHEMBL319620; C14H13NO5; 2-Hydroxy-5-(2,5-dihydrobenzyl)aminobenzoic acid; NSC666251; 2-HYDROXY-5-(2,5-DIHYDROXYBENZYLAMINO)BENZOIC ACID; 5-[(2,5-dihydroxyphenyl)methylamino]-2-hydroxybenzoic acid; 5-(((2,5-Dihydroxyphenyl)methyl)amino)-2-hydroxybenzoic acid; 5-[[(2,5-dihydroxyphenyl)methyl]amino]-2-hydroxy-benzoic acid; Benzoic acid,5-[[(2,5-dihydroxyphenyl)methyl]amino]-2-hydroxy-; NSC 666251; 5-[[(2,5-Dihydroxyphenyl)methyl]amino]-2-hydroxybenzoic acid; Benzoic acid, 5-(((2,5-dihydroxyphenyl)methyl)amino)-2-hydroxy-; Benzoic acid, 5-[[(2,5-dihydroxyphenyl)methyl]amino]-2-hydroxy-; MFCD00153955; Lavendustin C (HDBA); BiomolKI_000039; 9-CIS-RETINOICACID; ACMC-20c89k; BiomolKI2_000047; BMK1-E3; 2-Hydroxy-5-(2,5-dihydrobenzyl) aminobenzoic acid; SCHEMBL1821516; CTK4B4739; Lavendustin C, >=97%, solid; DTXSID60154856; ZINC388549; BCP20731; 1815AH; BDBM50038199; HSCI1_000196; CCG-100643; CS-W014573; HY-W013857; NSC-666251; NCGC00163380-01; NCI60_023006; FT-0619570; A805844; 5-(N-2'',5''-dihydroxybenzyl)aminosalicylic acid; J-005266; 5-(2,5-Dihydroxy-benzylamino)-2-hydroxy-benzoic acid; BRD-K80725632-001-02-2; Q27166541; 5-[(2,5-dihydroxyphenyl)methylamino]-2-hydroxy-benzoic acid; 5-(2,5-dihydroxybenzylamino)-2-hydroxybenzoic acid; Lavendustin C; 5-[[2,5-bis(oxidanyl)phenyl]methylamino]-2-oxidanyl-benzoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 92000 nM
|
[94] | |||
| Compound Name |
Ethyl 4-{[({5-[(4-methoxyanilino)methyl]-4-phenyl-4H-1,2,4-triazol-3-yl}sulfanyl)acetyl]amino}benzoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1944931; ZINC6089575; BDBM50363488; MCULE-1644993499; AG-690/40750391
Click to Show/Hide
|
||||
| Activity |
IC50 = 92400 nM
|
[87] | |||
| Compound Name |
2-(6-Amino-9H-purin-9-yl)-1-(pyridin-3-yl)ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL501256; BDBM50268239; 2-(6-Amino-9H-purine-9-yl)-1-(pyridine-3-yl)ethanone
Click to Show/Hide
|
||||
| Activity |
IC50 = 93000 nM
|
[86] | |||
| Compound Name |
4-Amino-7-(2-hydroxyethylamino)pyrido[2,3-d]pyrimidine-6-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910268; BDBM50356614
Click to Show/Hide
|
||||
| Activity |
IC50 = 93300 nM
|
[78] | |||
| Compound Name |
1-[5,21-Dihydroxy-12,14-dioxo-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaen-13-yl]-3-phenylurea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL19978; BDBM50076937
Click to Show/Hide
|
||||
| Activity |
IC50 = 95000 nM
|
[73] | |||
| Compound Name |
2-[(5-Hydroxy-2-nitrophenyl)methylidene]propanedinitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
benzylidenemalononitrile (BMN) deriv. 20; CHEMBL77085; BDBM4336; Propanedinitrile, 2-[(5-hydroxy-2-nitrophenyl)methylene]-; MCK100052
Click to Show/Hide
|
||||
| Activity |
IC50 = 96000 nM
|
[30] | |||
| Compound Name |
N4-(2-Isopropylphenyl)-6-(2,4-dichlorobenzyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1095776; BDBM50318181
Click to Show/Hide
|
||||
| Activity |
IC50 = 96400 nM
|
[67] | |||
| Compound Name |
US9422297, Aag155-336
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3902576; BDBM242732
Click to Show/Hide
|
||||
| Activity |
IC50 = 98800 nM
|
[95] | |||
| Compound Name |
4-N-(3-Bromophenyl)-7-[(4-chlorophenyl)methyl]pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956891; BDBM50366090
Click to Show/Hide
|
||||
| Activity |
IC50 = 99900 nM
|
[25] | |||
| Compound Name |
6-(4-Amino-1-cyclopentyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-4H-chromen-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242119
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[43] | |||
| Compound Name |
Dithiobis(1H-indole-3-alkanoic acid) deriv. 36
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM3988; CHEMBL420400; Dimethyl 2,2 -Dithiobis(1H-indole-3-butanoate); 2,2'-Dithiobis(1H-indole-3-butanoic acid methyl) ester; methyl 4-(2-{[3-(4-methoxy-4-oxobutyl)-1H-indol-2-yl]disulfanyl}-1H-indol-3-yl)butanoate
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[61] | |||
| Compound Name |
3-[(Z)-(4-Bromo-2-thienyl)methylidene]-1H-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL316268; (3Z)-3-[(4-bromothiophen-2-yl)methylidene]-2,3-dihydro-1H-indol-2-one; SCHEMBL5728269; ZINC5903417; BDBM50065319; MFCD03012811; AKOS005094253; 5T-0045; 3-[1-(4-Bromo-thiophen-2-yl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
Dithiobis(1H-indole-3-alkanoic acid) deriv. 24
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM3976; CHEMBL311811; Dimethyl 2,2 -Thiobis(1-methyl-1H-indole-3-acetate); 2,2'-Thiobis(1-methyl-1H-indole-3-acetic acid methyl) ester
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[61] | |||
| Compound Name |
(6,7,8,9-Tetrahydro-5H-pyrimido[4,5-b]indol-4-yl)-m-tolyl-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL307062; SCHEMBL2460990; BDBM50051300
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
1-Methyl-2-methylsulfanyl-N-phenylindole-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
1-Methyl-2-(methylthio)-N-phenyl-1H-indole-3-carboxamide; 2-thioxo-1H-indole-3-carboxamide deriv. 12; CHEMBL64814; BDBM4046; 1-methyl-2-(methylsulfanyl)-N-phenyl-1H-indole-3-carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[65] | |||
| Compound Name |
(Z)-1-Methyl-3-(4-dimethylaminobenzylidene)indoline-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL86921; SCHEMBL14589616; ZINC586193; BDBM50065315; MCULE-4166796331; 3-[1-(4-Dimethylamino-phenyl)-meth-(Z)-ylidene]-1-methyl-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
4-[[4-Amino-6-cyano-2-(2-hydroxyethylamino)pyrido[2,3-d]pyrimidin-7-yl]amino]benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910276; BDBM50356622
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[78] | |||
| Compound Name |
3-[[2-(4-Morpholin-4-ylanilino)pyrimidin-4-yl]amino]benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3884240; BDBM50208588
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[96] | |||
| Compound Name |
N-(4-Cyanophenyl)-4-(6,7-dimethoxyquinazolin-4-yl)piperazine-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL106966; SCHEMBL2921461; BDBM50115297; 4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-carboxylic acid (4-cyano-phenyl)-amide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[97] | |||
| Compound Name |
1 H-Indole-3-alkanamide deriv. 10q
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM4008; CHEMBL350882; 2,2-Dithiobis[N-benzyl-N-(trifluoroacetyl)tryptophanamide]
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[59] | |||
| Compound Name |
Indolin-2-one deriv. 4i
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM4912; CHEMBL313500; 6-(4-Methoxyphenyl)-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylene)-1,3-dihydroindol-2-one; 6-(4-Methoxyphenyl)-3-[4,5,6,7-tetrahydro-1H-indole-2-ylmethylene]-2-indolinone; (3Z)-6-(4-methoxyphenyl)-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylidene)-2,3-dihydro-1H-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
N-(3-Chloro-2-fluorophenyl)-8,9-dimethoxy-2-methyl-5,6-dihydropyrimido[4,5-b][1,4]benzoxazepin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL386052; BDBM50192470
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[75] | |||
| Compound Name |
Dithiobis(1H-indole-3-carboxamide) deriv. 10p
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM4031; CHEMBL303127; N,N'-Diphenyl[2,2'-dithiobis(6-chloro-1-methyl-1H-indole-3-carboxamide)]
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[65] | |||
| Compound Name |
4-Chloro-N-[3-fluoro-4-[6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinolin-4-yl]oxyphenyl]-1-(4-fluorophenyl)-2-oxoquinoline-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3780676; BDBM50152685
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[98] | |||
| Compound Name |
5-(3,6-Dimethoxy-cyclohexa-1,5-dienylmethoxy)-2-hydroxy-benzoic acid methyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL130633; BDBM50038201
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[99] | |||
| Compound Name |
4-[(4-Amino-6-cyano-5-methylpyrido[2,3-d]pyrimidin-7-yl)amino]benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910271; BDBM50356617
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[78] | |||
| Compound Name |
(3-Nitro-phenyl)-(4-pyridin-3-yl-pyrimidin-2-yl)-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL56081; SCHEMBL1977; 2-Pyrimidinamine,N-(3-nitrophenyl)-4-(3-pyridinyl)-; BDBM50290423; VCC117886; N-(3-nitrophenyl)-4-pyridin-3-ylpyrimidin-2-amine; 4-(3-Pyridinyl)-N-(3-nitrophenyl)pyrimidin-2-amine; N-(3-nitrophenyl)-4-(3-pyridyl)-2-pyrimidine-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[2] | |||
| Compound Name |
N-(3-Bromo-4-methylphenyl)-8,9-dimethoxy-2-methyl-5,6-dihydropyrimido[4,5-b][1,4]benzothiazepin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL383999; BDBM50192499
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[75] | |||
| Compound Name |
2-(1H-Benzimidazol-2-ylmethyl)-5-(4-fluorophenyl)-1,3,4-oxadiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4090323; BDBM50232342
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[47] | |||
| Compound Name |
1H-Indole-3-acetic acid, 2,3-dihydro-2-thioxo-, methyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-thioxo-1H-indole-3-alkanoic acid deriv. 7; BDBM3958; CHEMBL312001; SCHEMBL1388345; CTK1H5544; DTXSID40416166; methyl 2-(2-sulfanylidene-1,3-dihydroindol-3-yl)acetate; Methyl 2,3-Dihydro-2-thioxo-1H-indole-3-acetate; 2-Thioxo-2,3-dihydro-1H-indole-3-acetic acid methyl ester; methyl 2-(2-sulfanylidene-2,3-dihydro-1H-indol-3-yl)acetate
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[61] | |||
| Compound Name |
9-Methyl-9H-[1,2,4]triazolo[4,3-a]benzimidazole-3-thiol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1944922; 9-methyl-2,9-dihydro-3H-[1,2,4]triazolo[4,3-a]benzimidazole-3-thione; SCHEMBL16137338; ZINC105761; BBL010381; BDBM50363478; CCG-28973; MFCD03767537; SBB043946; STK713002; STK806058; AKOS000274292; AKOS001036444; MCULE-2829097600; NE36616; SDCCGMLS-0065128.P001; VS-02466; AR-422/40789596; Z56803664; F0863-0286; 9-methyl-9-hydro-1,2,4-triazolo[4,3-a]benzimidazole-3-thiol; 9-methyl-2H-benzo[4,5]imidazo[2,1-c][1,2,4]triazole-3(9H)-thione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[87] | |||
| Compound Name |
1-Isopropyl-3-(isoquinolin-7-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242208
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[43] | |||
| Compound Name |
2-Methoxy-5-[(2,5-dihydroxybenzylidene)amino]benzoic acid methyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL129989; BDBM50043329; 5-[(2,5-Dihydroxy-benzylidene)-amino]-2-methoxy-benzoic acid methyl ester
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[94] | |||
| Compound Name |
4',6-Diamino-5-hydroxyflavone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL116051; 4h-1-benzopyran-4-one,6-amino-2-(4-aminophenyl)-5-hydroxy-; BDBM50037405; ZINC13738764; 6-Amino-2-(4-amino-phenyl)-5-hydroxy-chromen-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[100] | |||
| Compound Name |
4,5-Bis(phenylthio)phthalimide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL8271; BDBM50040924; 5,6-Bis-phenylsulfanyl-isoindole-1,3-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
4-(6,7-Dimethoxy-4-quinazolinyl)-N-(4-nitrophenyl)-1-piperazinecarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL99743; SCHEMBL842459; BDBM50115295; KN1022; 4-(6,7-dimethoxyquinazolin-4-yl)-N-(4-nitrophenyl)piperazine-1-carboxamide; 4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-carboxylic acid (4-nitro-phenyl)-amide; 4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-carboxylic acid (4-nitro-phenyl)-amide(KN1022)
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[97] | |||
| Compound Name |
2-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)benzo[b]thiophene-5-carbaldehyde
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2437351; CHEMBL1241684; 2-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)benzo[b] thiophene-5-carbaldehyde; 2-(4-amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)-1-benzothiophene-5-carbaldehyde
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[43] | |||
| Compound Name |
Tert-butyl N-[(2R)-1-[[4-(3-bromoanilino)quinazolin-6-yl]amino]-1-oxopropan-2-yl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4083222; BDBM50237547
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[101] | |||
| Compound Name |
3-(3-Chlorophenyl)-5,7-dimethoxychromen-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL7981; SCHEMBL10622209; ZINC58157; 3'-Chloro-5,7-dimethoxyisoflavone; BDBM50074746; ST50309253; 3-(3-Chloro-phenyl)-5,7-dimethoxy-chromen-4-one; 5,7-Dimethoxy-3-(3-chlorophenyl)-4H-1-benzopyran-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[72] | |||
| Compound Name |
1-[(E)-(2,4-Difluorophenyl)methylideneamino]-3-[3-fluoro-4-[6-methoxy-7-[3-(4-methylpiperidin-1-yl)propoxy]quinolin-4-yl]oxyphenyl]urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2419669; BDBM50439772
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[102] | |||
| Compound Name |
Di(1,3-dimethyl-1H-2-indolyl) disulfide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL158879; BDBM50036018
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[103] | |||
| Compound Name |
3-Substituted indolin-2-one 16h
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM4902; CHEMBL146694; SCHEMBL4410831
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(E)-2-Cyano-N-[10-[[(E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enoyl]amino]decyl]-3-(3,4-dihydroxyphenyl)prop-2-enamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
NSC677211; Dimeric Tyrphostin 8; BDBM5155; CHEMBL424302; NSC-677211; N,N'-(Decane-1,10-diyl)bis[(E)-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide]
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[85] | |||
| Compound Name |
N-(3-Bromophenyl)-4-hydroxy-2-oxo-1,2-dihydro-3-quinolinecarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1944926; N-(3-bromophenyl)-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamide; Oprea1_246911; Oprea1_275092; BDBM50363482; STK838009; ZINC18069188; AKOS000624680; CCG-200670; MCULE-6882091021; EU-0065756; AG-690/40637133; SR-01000588676; SR-01000588676-1
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[87] | |||
| Compound Name |
5-(4-Amino-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-methoxyphenol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1241301
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[43] | |||
| Compound Name |
2-(1H-Benzimidazol-2-ylmethyl)-5-(furan-2-yl)-1,3,4-oxadiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4061912; BDBM50232333
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[47] | |||
| Compound Name |
6-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)quinolin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242034
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[43] | |||
| Compound Name |
N-[3-[(4-Pyridin-3-ylpyrimidin-2-yl)amino]phenyl]hexanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL56669; SCHEMBL9588; BDBM50290431; Hexanoic acid [3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-amide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
5-(3,6-Dimethoxy-cyclohexa-1,5-dienylmethoxy)-2-hydroxy-benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL131405; BDBM50038206
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[99] | |||
| Compound Name |
Dithiobis(1H-indole-3-carboxamide) deriv. 10f
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL63455; BDBM4021; SCHEMBL8998845; N,N'-Diphenyl[2,2'-dithiobis(5-fluoro-1-methyl-1H-indole-3-carboxamide)]
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[65] | |||
| Compound Name |
4-Methyl-N-[3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL59036; SCHEMBL9763; BDBM50290430; VCC783678; 4-Methyl-N-[3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N-Benzyl-4-(6,7-dimethoxyquinazolin-4-yl)piperazine-1-carbothioamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL319894; SCHEMBL2919724; BDBM50118831; N-Benzyl-4-(6,7-dimethoxyquinazoline-4-yl)piperazine-1-carbothioamide; 4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-carbothioic acid benzylamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[104] | |||
| Compound Name |
2-(3,4-Dihydroxybenzylidene)benzofuran-3(2H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3361128; BDBM50038423; ZINC16052822; (E)-2-(3,4-Dihydroxybenzylidene)benzofuran-3(2H)-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[105] | |||
| Compound Name |
Dithiobis(1H-indole-3-carboxamide) deriv. 10s
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL64068; BDBM4034; SCHEMBL8998859; N,N'-Diphenyl[2,2'-dithiobis(6-acetoxy-1-methyl-1H-indole-3-carboxamide)]
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[65] | |||
| Compound Name |
5,21-Dihydroxy-13-(methylamino)-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL277667; BDBM50076940
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[73] | |||
| Compound Name |
Methyl 3-(1-methyl-2-sulfanylidene-3H-indol-3-yl)propanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-thioxo-1H-indole-3-alkanoic acid deriv. 12; BDBM3963; CHEMBL311609; SCHEMBL8999377; Methyl 2,3-Dihydro-1-methyl-2-thioxo-1H-indole-3-propanoate; 1-Methyl-2-thioxo-2,3-dihydro-1H-indole-3-propionic acid methyl ester; methyl 3-(1-methyl-2-sulfanylidene-2,3-dihydro-1H-indol-3-yl)propanoate
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[61] | |||
| Compound Name |
3-(4-(Dimethylamino)benzylidene)-1,3-dihydro-2H-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SU 4312; SU-4312; NSC86429; NSC 86429; CHEMBL328710; 3-[[4-(dimethylamino)phenyl]methylene]-1,3-dihydro-2H-indol-2-one; SU4312; SR-01000076222; BiomolKI_000054; BiomolKI2_000060; UPCMLD-DP118; cis-SU 4312; Lopac0_001121; BMK1-F6; BSPBio_000998; SCHEMBL1982207; UPCMLD-DP118:001; UPCMLD-DP118:002; BDBM17747; HMS1362B19; HMS1792B19; HMS1990B19; HMS3263B03; HMS3403B19; HMS3412D03; HMS3676D03; BCP20743; Tox21_501121; NSC-86429; STK946565; ZINC12339625; AKOS005640946; CCG-100658; LP01121; SDCCGSBI-0051089.P002; SU4312(NSC86429); IDI1_002094; NCGC00025170-02; NCGC00025170-03; NCGC00025170-04; NCGC00025170-05; NCGC00025170-06; NCGC00025170-07; NCGC00025170-08; NCGC00025170-09; NCGC00025170-10; NCGC00025170-11; NCGC00025170-12; NCGC00025170-14; NCGC00261806-01; B6746; EU-0101121; EC-000.2453; S 8567; (Z)-3-(4-(dimethylamino)benzylidene)indolin-2-one; SR-01000076222-1; SR-01000076222-3; BRD-K20287671-001-01-0; (3Z)-3-[(4-dimethylaminophenyl)methylene]indolin-2-one; DMBI; (Z)-3-(4-(dimethylamino)benzylidene)indolin-2-one; (3Z)-3-[[4-(dimethylamino)phenyl]methylidene]-1H-indol-2-one; (3Z)-3-[4-(dimethylamino)benzylidene]-1,3-dihydro-2H-indol-2-one; (3Z)-3-{[4-(dimethylamino)phenyl]methylidene}-2,3-dihydro-1H-indol-2-one; SU-4312; SU4312. DMBI; NSC 86429; NSC-86429; NSC86429
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
Indolin-2-one deriv. 4f
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM4909; CHEMBL313746; 6-Phenyl-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylene)-1,3-dihydroindol-2-one; (3Z)-6-phenyl-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylidene)-2,3-dihydro-1H-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
N-(3-Bromophenyl)phthalazin-1-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
phthalazine deriv. 23; BDBM3272; CHEMBL326095; ZINC13743121
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[106] | |||
| Compound Name |
4,5-Bis[4-cyanoanilino]phthalimide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL267869; SCHEMBL8835258; BDBM50040928; 4-[[6-(4-cyanoanilino)-1,3-dioxoisoindol-5-yl]amino]benzonitrile; 4-[6-(4-cyanoanilino)-1,3-dioxo-2,3-dihydro-1H-5-isoindolylamino]benzonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
1-Isopropyl-3-(pyrimidin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL3616915; CHEMBL1241391; US9765037, Compound 18; BDBM340891; 1-propan-2-yl-3-pyrimidin-5-ylpyrazolo[3,4-d]pyrimidin-4-amine; 1-isopropyl-3-(pyrimidin-5-yl)-1H-pyrazolo[3,4- d]pyrimidin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[43] | |||
| Compound Name |
3N-(3-Pyridyl)-1-methyl-2-[1-methyl-3-(3-pyridylcarbamoyl)-1H-2-indolyldisulfanyl]-1H-3-indolecarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL352010; SCHEMBL8999317; BDBM50036007
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[103] | |||
| Compound Name |
Methyl 4-{1-methyl-2-[1-methyl-3-(4-methyloxycarbonylphenylcarbamoyl)-1H-2-indolyldisulfanyl]-1H-3-indolylcarboxamido}benzoate H2O
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL348069; SCHEMBL8999420; BDBM50036010
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[103] | |||
| Compound Name |
3-[1-(3-Tert-Butyl-4-methoxy-phenyl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL86945; BDBM50065318; ZINC13780159
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
Dithiobis(1H-indole-3-carboxamide) deriv. 10q
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL64459; BDBM4032; N,N'-Diphenyl[2,2'-dithiobis(1,6-dimethyl-1H-indole-3-carboxamide)]
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[65] | |||
| Compound Name |
3-Substituted indolin-2-one 16g
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL358728; BDBM4901; SCHEMBL4408641
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(3-Imidazol-1-yl-phenyl)-(4-pyridin-3-yl-pyrimidin-2-yl)-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL291963; SCHEMBL6256104; BDBM50045481; N-(3-imidazol-1-ylphenyl)-4-pyridin-3-ylpyrimidin-2-amine; 4-(3-Pyridinyl)-N-[3-(1H-imidazol-1-yl)phenyl]pyrimidin-2-amine; N-[3-(1H-imidazol-1-yl)phenyl]-4-(3-pyridinyl)-2-pyrimidinamine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(3-Nitro-phenyl)-(4-pyridin-2-yl-pyrimidin-2-yl)-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL60816; SCHEMBL1886; BDBM50290424; N-(3-nitrophenyl)-4-pyridin-2-ylpyrimidin-2-amine; 4-(2-Pyridinyl)-N-(3-nitrophenyl)pyrimidin-2-amine; N-(3-nitrophenyl)-4-(2-pyridyl)-2-pyrimidine-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
1-Phenyl-3-[[5-(thiophen-3-ylmethyl)-1,3-thiazole-2-carbonyl]amino]urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1944925; BDBM50363481
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[87] | |||
| Compound Name |
Methyl 2-(1-methyl-2-sulfanylidene-3H-indol-3-yl)acetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-thioxo-1H-indole-3-alkanoic acid deriv. 8; CHEMBL80001; BDBM3959; SCHEMBL1388649; Methyl 2,3-Dihydro-l-methyl-2-thioxo-1H-indole-3-acetate; 1-Methyl-2-thioxo-2,3-dihydro-1H-indole-3-acetic acid methyl ester; methyl 2-(1-methyl-2-sulfanylidene-2,3-dihydro-1H-indol-3-yl)acetate
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[61] | |||
| Compound Name |
2-Thioxo-1H-indole-3-alkanoic acid deriv. 19
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM3970; CHEMBL309513; Trimethyl 1,2-Dihydro-2-thioxo-1H-indole-1,3,3-tripropanoate; 2-Thioxo-2,3-dihydro-1H-indole-1,3,3-tris(propionic acid methyl) ester; methyl 3-[1,3-bis(3-methoxy-3-oxopropyl)-2-sulfanylidene-2,3-dihydro-1H-indol-3-yl]propanoate
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[61] | |||
| Compound Name |
3-Substituted indolin-2-one 11e
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SU5402 analog 11e; BDBM4891; CHEMBL347074; SCHEMBL4405755; 3-[4-Methyl-5-(2-oxo-6-phenyl-1,2-dihydroindol-3-ylidenemethyl)-1H-pyrrol-3-yl]propionic Acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-[Phenyl(methyl)amino]-5-anilinophthalimide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL7775; SCHEMBL8834465; BDBM50040917; 4-(N-Methyl-N-phenylamino)-5-anilino-phthalimide; 5-anilino-6-(N-methylanilino)isoindole-1,3-dione; 5-(Methyl-phenyl-amino)-6-phenylamino-isoindole-1,3-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
5-[(2,5-Dihydroxybenzylidene)amino]salicylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
NSC655254; CHEMBL316764; CHEMBL520491; ZINC1634584; BDBM50040295; BDBM50478479; NSC-655254; 5-((2,5-Dihydroxybenzylidene)amino)-2-hydroxybenzoic acid; 5-[(2,5-Dihydroxy-benzylidene)-amino]-2-hydroxy-benzoic acid; 5-[(E)-(2,5-dihydroxyphenyl)methyleneamino]-2-hydroxy-benzoic acid; 5-{[1-(2,5-Dihydroxy-phenyl)-meth-(E)-ylidene]-amino}-2-hydroxy-benzoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[94] | |||
| Compound Name |
5-(4-Amino-1-((piperidin-4-yl)methyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-chloropheno
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1241859
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[43] | |||
| Compound Name |
N-(3-Bromophenyl)isoquinolin-1-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
isoquinoline deriv. 21; CHEMBL39563; BDBM3270; ZINC390461; AKOS024327640; MCULE-6029043837
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[107] | |||
| Compound Name |
4-Amino-7-(2-hydroxyethylamino)-5-methylpyrido[2,3-d]pyrimidine-6-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910269; BDBM50356615
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[78] | |||
| Compound Name |
N-(3-Bromophenyl)-8,9-dimethoxy-N-methyl-5,6-dihydropyrimido[4,5-b][1,4]benzothiazepin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL215280; BDBM50192503
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[75] | |||
| Compound Name |
3-(2-Chloroquinolin-3-yl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242663
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[43] | |||
| Compound Name |
1-Isopropyl-3-(2,4-dimethoxypyrimidin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL3607903; CHEMBL1242846; 3-(2,4-dimethoxypyrimidin-5-yl)-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[43] | |||
| Compound Name |
Ethyl 2-[5-[(2,5-dihydroxyphenyl)methylideneamino]-2-hydroxyphenyl]acetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL168425; BDBM50453593
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[33] | |||
| Compound Name |
4-[4-[3-(Dimethylamino)-2-methylpropanoyl]phenoxy]sulfonylbenzoic acid;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL543600
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[79] | |||
| Compound Name |
5-(4-Amino-1-((5-methyl-2-phenyl-2H-1,2,3-triazol-4-yl)methyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-fluorophenol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242845
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[43] | |||
| Compound Name |
(3Z)-3-[(4-Bromophenyl)methylidene]-1H-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SU 4942; CHEMBL86837; 3-(4-Bromobenzylidene)-1,3-dihydroindol-2-one; 3-(4-Bromobenzylidene)indolin-2-one; SU4942; SCHEMBL5465141; ZINC574906; BCP20736; BDBM50065305; MFCD00435354; 3-(4-Bromobenzylidene)indoline-2-one; AKOS001575405; (3Z)-3-(4-bromobenzylidene)-1,3-dihydro-2H-indol-2-one; 3-[1-(4-Bromo-phenyl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
3-Substituted indolin-2-one 11g
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SU5402 analog 11g; BDBM4893; CHEMBL147112; SCHEMBL4408809
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Dithiobis(1H-indole-3-carboxamide) deriv. 10c
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM4018; CHEMBL292287; N,N'-Diphenyl[2,2'-dithiobis(1,4-dimethyl-1H-indole-3-carboxamide)]
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[65] | |||
| Compound Name |
1-Isopropyl-3-(2-methylquinolin-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1241682
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[43] | |||
| Compound Name |
N-[3-(4-Pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-nicotinamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL418270; 2-Amino-pyrimidine, 19; SCHEMBL1522; BDBM50290417; VCC225408; N-[3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]pyridine-3-carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N'-(4-Chloro-2-methylphenyl)-4-ethylbenzohydrazide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1944927; ZINC147500; BDBM50363483; MCULE-3848921114
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[87] | |||
| Compound Name |
N-[4-Methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL423288; SCHEMBL19556857; BDBM50240406; N-(4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)acetamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
4-Pyridin-4-yl-N-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]pyrimidin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL55662; SCHEMBL1269; BDBM50290420; 4-(4-Pyridinyl)-N-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]pyrimidin-2-amine; N-[3-(1,1,2,2-tetrafluoro-ethoxy)-phenyl]-4(4-pyridyl)-2-pyrimidineamine; N-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]-4-(4-pyridyl)-2-pyrimidine-amine; (4-Pyridin-4-yl-pyrimidin-2-yl)-[3-(1,1,2,2-tetrafluoro-ethoxy)-phenyl]-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
3-[1-(4-Piperidin-1-yl-phenyl)-ethylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL314798; SCHEMBL19451599; BDBM50065293; 3-[1-(4-Piperidin-1-yl-phenyl)-eth-(E)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
3-(4-Dimethylamino-benzylidene)-4-methyl-1,3-dihydro-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL89809; BDBM50065294; 3-[1-(4-Dimethylamino-phenyl)-meth-(Z)-ylidene]-4-methyl-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
(E)-2-Cyano-N-[[3-[[[(E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enoyl]amino]methyl]cyclohexyl]methyl]-3-(3,4-dihydroxyphenyl)prop-2-enamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Dimeric Tyrphostin 10; BDBM5157; CHEMBL357161; N,N'-[(Cyclohexane-1,3-diyl)bismethylene]bis[(E)-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide]
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[85] | |||
| Compound Name |
2-Thioxo-1H-indole-3-carboxamide deriv. 13
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL64781; BDBM4047; l-Methyl-N-phenyl-2-(phenyldithio)-1H-indole-3-carboxamide; 1-Methyl-2-(phenyldithio)-N-phenyl-1H-indole-3-carboxamide; 1-methyl-N-phenyl-2-(phenyldisulfanyl)-1H-indole-3-carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[65] | |||
| Compound Name |
N-[4-Methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]naphthalene-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL20252; SCHEMBL9837; BDBM50287091; VCC051689; Naphthalene-2-carboxylic acid [4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-amide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
2-Cyano-3-[3-(6-ethoxy-benzothiazol-2-ylsulfanylmethyl)-4-hydroxy-5-methoxy-phenyl]-acrylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL117055; BDBM50036693; alpha-Carbamoyl-3-[[(6-ethoxybenzothiazol-2-yl)thio]methyl]-4-hydroxy-5-methoxybenzenepropenenitrile
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[36] | |||
| Compound Name |
Dithiobis(1H-indole-3-carboxamide) deriv. 10d
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM4019; CHEMBL294205; N,N'-Diphenyl[2,2'-dithiobis(4-methoxy-1-methyl-1H-indole-3-carboxamide)]
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[65] | |||
| Compound Name |
4-[(2-Chloro-6,7-dimethoxyquinazolin-4-yl)amino]benzenesulfonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3098323; BDBM50444622
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[74] | |||
| Compound Name |
3N-Phenyl-2-(3-phenylcarbamoyl-1H-2-indolyldisulfanyl)-1H-3-indolecarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL345641; SCHEMBL8999391; BDBM50035998
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[103] | |||
| Compound Name |
N-Butyl-4-(4-formylphenoxysulfonyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL74038; BDBM50007066; 4-Butylcarbamoyl-benzenesulfonic acid 4-formyl-phenyl ester
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[56] | |||
| Compound Name |
3-[1-(4-Piperidin-1-yl-phenyl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL315701; SCHEMBL6001605; BDBM50065276
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
(3Z)-3-[4-(Morpholin-4-yl)benzylidene]-1,3-dihydro-2H-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL86480; SCHEMBL1452713; HMS1404H09; ZINC3262621; BDBM50065280; STK114426; AKOS005399481; IDI1_007326; 3-(4-Morpholinobenzylidene)indolin-2-one; (Z)-3-(4-Morpholinobenzylidene)indolin-2-one; 3-[1-(4-Morpholin-4-yl-phenyl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
(5,6-Dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-(3-fluoro-phenyl)-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL308582; SCHEMBL2460989; BDBM50051307; N-(3-fluorophenyl)-5,6-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
(5,6-Dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-(2-ethyl-phenyl)-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL310923; SCHEMBL2461566; BDBM50051313; N-(2-ethylphenyl)-5,6-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
Methyl 3-{1-methyl-2-[1-methyl-3-(3-methyloxycarbonylphenylcarbamoyl)-1H-2-indolyldisulfanyl]-1H-3-indolylcarboxamido}benzoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL158596; SCHEMBL8999038; BDBM50036017
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[103] | |||
| Compound Name |
N-[4-(3-Bromo-phenylamino)-quinazolin-6-yl]-2-methoxy-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL192737; SCHEMBL4586021; BDBM50171521; N-[4-(3-bromoanilino)quinazolin-6-yl]-2-methoxyacetamide; N-{4-[(3-bromophenyl)amino]-quinazolin-6-yl}-2-methoxyacetamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[51] | |||
| Compound Name |
Sdz-lap-977
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SDZ281-977; CHEMBL129856; methyl 5-[2-(2,5-dimethoxyphenyl)ethyl]-2-hydroxybenzoate; 5-[2-(2,5-Dimethoxyphenyl)ethyl]-2-hydroxy-Benzoic acid methyl ester; SCHEMBL8951153; ZINC5724; BDBM50038200; CS-6659; HY-101756; 5-(2,5-Dimethoxyphenethyl)salicylic acid methyl ester; methyl 5-(2,5-dimethoxyphenethyl)-2-hydroxybenzoate; 5-[2-(2,5-Dimethoxy-phenyl)-ethyl]-2-hydroxy-benzoic acid methyl ester
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[99] | |||
| Compound Name |
4',6,8-Triamino-7-hydroxyflavone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL115601; BDBM50037409; 6,8-Diamino-2-(4-amino-phenyl)-7-hydroxy-chromen-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[100] | |||
| Compound Name |
4-(4-Amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)-2-chlorobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1241862
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[43] | |||
| Compound Name |
5-Nitro-3-(1H-pyrrol-2-ylmethylene)-1,3-dihydro-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL87325; SCHEMBL6000878; BDBM50065287; 5-Nitro-3-[1-(1H-pyrrol-2-yl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
4-([r]-1-Phenylethylamino)indolo[3,2-d]pyrimidine hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL7215563; SCHEMBL7215566; CHEMBL2094036
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[108] | |||
| Compound Name |
Tert-butyl N-[(2R)-1-[[4-(3-chloro-4-fluoroanilino)quinazolin-6-yl]amino]-1-oxopropan-2-yl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4080555; BDBM50237555
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[101] | |||
| Compound Name |
N-[4-Chloro-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL278630; BDBM50287094
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[84] | |||
| Compound Name |
Di(3-phenyl-1H-2-indolyl) disulfide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL422540; BDBM50036005; Bis(3-phenyl-1H-indole-2-yl) persulfide; 3-phenyl-2-[(3-phenyl-1H-indol-2-yl)disulfanyl]-1H-indole
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[103] | |||
| Compound Name |
Indolin-2-one deriv. 9h
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM4921; CHEMBL313821; SCHEMBL6392692; 2-[6-(2-Methoxyphenyl)-2-oxo-3-indolinylidenemethyl]-4,5,6,7-tetrahydro-1H-indole-3-propionic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
3-(5-((6-(3,5-Dimethoxyphenyl)-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrol-3-yl)propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL231526; NP603; BDBM50217602; ZINC28704669; NP603, >=98% (HPLC)
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[109] | |||
| Compound Name |
2-Thioxo-1H-indole-3-alkanoic acid deriv. 17
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL82640; BDBM3968; 2-Thioxo-2,3-dihydro-1H-indole-3,3-dipropionic acid; 3-[3-(2-carboxyethyl)-2-sulfanylidene-2,3-dihydro-1H-indol-3-yl]propanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[61] | |||
| Compound Name |
7-Aminopyrido[4,3-d]pyrimidine 8s
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM3349; CHEMBL121984; N-(4-Dimethylaminobenzyl)pyrido[4,3-d]pyrimidine-4,7-diamine; 4-N-{[4-(dimethylamino)phenyl]methyl}pyrido[4,3-d]pyrimidine-4,7-diamine; 7-amino-4-[[[4-(dimethylamino)phenyl]methyl]amino]pyrido[4,3-d]pyrimidine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[76] | |||
| Compound Name |
1-Methyl-N-phenyl-2-sulfanylidene-3H-pyrrolo[2,3-b]pyridine-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-thioxo-1H-indole-3-carboxamide deriv. 9z; CHEMBL62699; BDBM4044; 1,3-dihydro-1-methyl-N-phenyl-2-thioxo-2H-pyrrolo[2,3-b]pyridine-3-carboxamide; 1-methyl-N-phenyl-2-sulfanylidene-1H,2H,3H-pyrrolo[2,3-b]pyridine-3-carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[65] | |||
| Compound Name |
1,4-Diphenyl-1,2,3,4-tetrahydro-pyrrolo[3,4-g]quinoxaline-6,8-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL266255; BDBM50040913; 1,4-Diphenyl-1,2,3,4-tetrahydroquinoxaline-6,7-dicarbimide; 1,4-diphenyl-2,3-dihydropyrrolo[3,4-g]quinoxaline-6,8-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
3-(5-Methyl-furan-2-ylmethylene)-1,3-dihydro-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL89697; BDBM50065309; 3-[1-(5-Methyl-furan-2-yl)-meth-(E)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
(3Z)-4-Methyl-3-(1H-pyrrol-2-ylmethylidene)-2,3-dihydro-1H-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL85403; Indolinone based inhibitor, 1a; SCHEMBL5728466; BDBM17016
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
2-Methoxy-N-[3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL299707; SCHEMBL9338; BDBM50290429; VCC092935; 2-Methoxy-N-[3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide; 2-Methoxy-N-[3-[[4-(3-pyridinyl)pyrimidin-2-yl]amino]phenyl]benzamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[2] | |||
| Compound Name |
3-[(Z)-(3-Bromo-2-thienyl)methylidene]-1H-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL87783; (3Z)-3-[(3-bromothiophen-2-yl)methylidene]-2,3-dihydro-1H-indol-2-one; ZINC4038356; BDBM50065272; MFCD05975006; AKOS005076668; 10X-0879; 3-[1-(3-Bromo-thiophen-2-yl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
Dithiobis(1H-indole-3-carboxamide) deriv. 10i
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL60200; BDBM4024; N,N'-Diphenyl[2,2'-dithiobis(1,5-dimethyl-1H-indole-3-carboxamide)]
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[65] | |||
| Compound Name |
9H-Imidazo(4,5-H)isoquinolin-9-one, 2-((2,6-dichlorophenyl)amino)-1,8-dihydro-6,7-dimethyl-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BIRA-0596; UNII-0U6QL95YQD; 0U6QL95YQD; CHEMBL27085; SCHEMBL676660; SCHEMBL4960262; BDBM50116391; Q27237262; 2-(2,6-dichloroanilino)-6,7-dimethyl-3,8-dihydroimidazo[4,5-h]isoquinolin-9-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[110] | |||
| Compound Name |
Methyl 2-[5-[(2,5-dihydroxyphenyl)methylideneamino]-2-hydroxyphenyl]acetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL169081; BDBM50453588
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[33] | |||
| Compound Name |
7-Hydroxy-2-[[7-hydroxy-1-methyl-3-(phenylcarbamoyl)indol-2-yl]disulfanyl]-1-methyl-N-phenylindole-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
dithiobis(1H-indole-3-carboxamide) deriv. 10y; CHEMBL62843; BDBM4040; SCHEMBL8998776
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[65] | |||
| Compound Name |
1-Methyl-2-[[1-methyl-3-(thiophen-2-ylcarbamoyl)indol-2-yl]disulfanyl]-N-thiophen-2-ylindole-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL345622; SCHEMBL8999355; BDBM50035997
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[103] | |||
| Compound Name |
4-[[5,13-Diamino-11-(2-hydroxyethylamino)-4-thia-8,10,12-triazatricyclo[7.4.0.02,6]trideca-1(13),2,5,7,9,11-hexaen-7-yl]amino]benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910279; BDBM50356625
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[78] | |||
| Compound Name |
Arcyriaflavin a
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
12,13-Dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione; CHEMBL268368; LSM-3627; Arcyriaflavin A, Synthetic; STAUROSPORINE AGLYCON; BDBM2672; SCHEMBL8124103; CTK8F0260; DTXSID50416132; QCR-238; HMS3229B05; HMS3269E19; HMS3413O10; HMS3677O10; BCP24907; ZINC12354940; AKOS024457112; NCGC00159573-01; NCGC00159573-02; DB-081253; B7063; FT-0701521; J-003757; BRD-K72726508-001-01-3; Q27164989; 12,13-Dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5 ,7(6H)-dione; 5H-Indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione, 12,13-dihydro-; 6,7,12,13-Tetrahydro-5,7-dioxo-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
6-methyl-N1-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine; 2-(5-Amino-2-methylanilino)-4-(3-pyridyl)pyrimidine; JR9RZF7KDS; UNII-JR9RZF7KDS; CHEMBL278103; 4-methyl-3-N-(4-pyridin-3-ylpyrimidin-2-yl)benzene-1,3-diamine; 1,3-Benzenediamine, 4-methyl-N3-[4-(3-pyridinyl)-2-pyrimidinyl]-; N-(5-Amino-o-tolyl)-4-(3-pyridyl)-2-pyrimidinamine; N-(5-Amino-2-methylphenyl)-4-(3-pyridinyl)-2-pyrimidineamine; 4-Methyl-N3-[4-(3-Pyridinyl)-2-Pyrimidinyl]-1,3-Benzenediamine; 4-methyl-3-[4-(3-pyridyl)pyrimidin-2-ylamino]aniline; 1,3-Benzenediamine, 4-methyl-N3-(4-(3-pyridinyl)-2-pyrimidinyl)-; 4-Methyl-N*3*-(4-pyridin-3-yl-pyrimidin-2-yl)-benzene-1,3-diamine; N-(5-Amino-2-methylphenyl)-4-(3-pridyl)-2-pyrimidineamine; Imatinib amine; 4-Methyl-N3-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine; 4-Methyl-N3-[4-(pyridin-3-yl)pyrimidin-2-yl]benzene-1,3-diamine; 6-METHYL-N1-[4-(PYRIDIN-3-YL)PYRIMIDIN-2-YL]BENZENE-1,3-DIAMINE; zlchem 1354; Imatinib amine [USP]; PubChem18212; Imatinib EP Impurity F; ACMC-209d7r; SCHEMBL2392; KSC174K2P; BEN021; CTK0H4527; DTXSID30433443; ZLE0132; Imatinib related compound F [USP]; ACT04895; BCP22918; AC-619; ANW-21397; BDBM50287097; CA0157; MFCD09028125; VCC489937; ZINC21985310; AKOS015888614; AC-2147; ACN-026829; CCG-310976; CS-W014568; DS-0284; LS41060; MCULE-2150821496; QC-1118; 112GI007; AK-23922; AT-20154; BR-23922; SC-19340; AB0005260; A3351; AM20050827; FT-0647597; FT-0655675; FT-0696298; VU0549314-1; M-1404; 460A101; Q-100177; N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimid; F9995-0188; 3-[[4-(3-Pyridinyl)pyrimidine-2-yl]amino]-4-methylaniline; n-(2-methyl-5-aminophenyl)-4-(3-pyridyl)-2-pyrimidine amine; N-(5-Amino-2-methyl phenyl)-4-(3-pyridyl)-2-pyrimidineamine; N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2- pyrimidineamine; N-(5-amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidine amine; N-(5-amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidine-amine; 1,3-Benzenediamine, 4-methyl-N3-[4-(3-pyridinyl)-2-pyrimidinyl; 4-Methyl-N-3-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine; 4-methyl-N~3~-(4-pyridin-3-ylpyrimidin-2-yl)benzene-1,3-diamine; 4-Methyl-N3-(4-pyridin-3-yl-pyrimidin-2-yl)-benzene-1,3-diamine; 4-methyl-N3-[4-(3-piridinyl)-2-pirimidinyl]-1,3-benzendiamine; 4-Methyl-N3-[4-(3-pyridyl)-2-pyrimidinyl]-1,3-phenylenediamine; 6-Methyl-N-(4-(pyridine-3-yl)pyrimidin-2-yl)benzene-1,3-diamine; 6-Methyl-N1-(4-(pyridine-3-yl)pyrimidin-2-yl)benzene-1,2-diamine; N-(5-amino-2-methyl phenyl)-4-(3-pyridinyl)2-pyrimidine-amine; N-(5-amino-2-methylphenyl)-4-(3-pyridinyl)-2-pyrimidine-amine; 4-Methyl-N~3~-[4-(pyridin-3-yl)pyrimidin-2-yl]benzene-1,3-diamine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
2-Thioxo-1H-indole-3-alkanoic acid deriv. 18
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM3969; CHEMBL312247; Dimethyl 1,2-dihydro-2-thioxo-3H-indole-3,3-dipropanoate; 2-Thioxo-2,3-dihydro-1H-indole-3,3-bis(propionic acid methyl) ester; methyl 3-[3-(3-methoxy-3-oxopropyl)-2-sulfanylidene-2,3-dihydro-1H-indol-3-yl]propanoate
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[61] | |||
| Compound Name |
(3-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl)methanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL3607897; CHEMBL1241582; (3-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl) methanol; [3-(4-amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)phenyl]methanol
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[43] | |||
| Compound Name |
6-(2,4-Dihydroxyphenyl)-4-methyl-2-(3-methyl-5-oxo-4-(thiophen-2-ylmethylene)-4,5-dihydro-1H-pyrazol-1-yl)-N-(3-nitrophenyl)-1,6-dihydropyrimidine-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1087566; BDBM50312571
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[111] | |||
| Compound Name |
2-Thioxo-1H-indole-3-carboxamide deriv. 11
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL63009; BDBM4045; 1,3-dimethyl-N-phenyl-2-thioxoindoline-3-carboxamide; 1,3-dimethyl-N-phenyl-2-sulfanylidene-2,3-dihydro-1H-indole-3-carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[65] | |||
| Compound Name |
N-Benzyl-3-(2-sulfanylidene-1,3-dihydroindol-3-yl)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
1 H-indole-3-alkanamide deriv. 11j; BDBM4015; CHEMBL154911; 2,3-Dihydro-2-thioxo-N-benzyl-1H-indole-3-propanamide; N-benzyl-3-(2-sulfanylidene-2,3-dihydro-1H-indol-3-yl)propanamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[59] | |||
| Compound Name |
5-(4-Amino-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-bromophenol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1241299
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[43] | |||
| Compound Name |
(3Z)-3-(4-Hydroxybenzylidene)-1,3-dihydro-2H-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL313578; SCHEMBL5470603; ZINC2939076; BDBM50065304; STK946564; AKOS002131864; 3-(4-Hydroxybenzylidenyl)-indolin-2-one; 3-[(Z)-4-Hydroxybenzylidene]indoline-2-one; J3.666.327H; SR-01000594632; J-017472; SR-01000594632-1; 3-[1-(4-Hydroxy-phenyl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
[5-[(2,5-Dihydroxyphenyl)methylamino]-2-hydroxyphenyl]methylphosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL352876; BDBM50453608
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[33] | |||
| Compound Name |
2-(1H-Indol-5-ylmethylidene)propanedinitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Propanedinitrile, (1H-indol-5-ylmethylene)-; Tyrphostin deriv. 13; ACMC-20muzg; Tyrphostin AG-410; BDBM4282; CHEMBL294213; SCHEMBL3791649; CTK0C0329; DTXSID20416169; MCK100175; ZINC13822311; AKOS006293071; 2-[(1H-indol-5-yl)methylidene]propanedinitrile; Propanedinitrile, 2-(1H-indol-5-ylmethylene)-
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[66] | |||
| Compound Name |
N-(3-Bromophenyl)quinoxalin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
quinoxaline deriv. 24; BDBM3273; CHEMBL331417; ZINC13743122
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[106] | |||
| Compound Name |
Indolin-2-one deriv. 9b
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM4915; CHEMBL314995; 2-(5-Bromo-2-oxo-3-indolinylidenemethyl)-4,5,6,7-tetrahydro-1H-indole-3-propionic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
2-(Benzylsulfonyl)-4-(2,4-dihydroxyphenyl)-6-methyl-N-p-tolylpyrimidine-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1086152; BDBM50312565
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[111] | |||
| Compound Name |
Dithiobis(1H-indoles) deriv. 4
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL336174; BDBM3351; 2,2'-Dithiobis[N-(phenylmethyl)-alpha-amino-1H-indole-3-propanamide]
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
Indolin-2-one deriv. 4h
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL88462; BDBM4911; SCHEMBL7834368; 6-(2-methoxyphenyl)-3-(4,5,6,7-tetrahydro-1h-indol-2-ylmethylene)-1,3-dihydroindol-2-one; 6-(2-Methoxyphenyl)-3-[4,5,6,7-tetrahydro-1H-indole-2-ylmethylene]-2-indolinone; (3Z)-6-(2-methoxyphenyl)-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylidene)-2,3-dihydro-1H-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
N-(2-Methyl-5-nitrophenyl)-4-pyridin-3-ylpyrimidin-2-amine; N-(2-Methyl-5-nitrophenyl)-4-(3-pyridyl)-2-pyrimidine-amine; n-(2-methyl-5-nitrophenyl)-4-(3-pyridyl)-2-pyrimidineamine; CHEMBL20426; 2-Pyrimidinamine, N-(2-methyl-5-nitrophenyl)-4-(3-pyridinyl)-; (2-Methyl-4-nitro-phenyl)-(4-pyridin-3-yl-pyrimidin-2-yl)-amine; MFCD02179269; N-(2-methyl-5-nitrophenyl)-4-(3-pyridyl)-2-pyrimidinamine; 2-Pyrimidinamine,N-(2-methyl-5-nitrophenyl)-4-(3-pyridinyl)-; 2-Methyl-5-nitro-N-[4-(pyridin-3-yl)pyrimidin-2-yl]benzenamine; SCHEMBL1550; ACMC-1C66W; KSC527I5D; N-(2-methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimid; PYR402; SCHEMBL13597737; CTK4C7451; DTXSID50443544; ACT04899; BCP12559; N-(2-methyl-5-nitro-phenyl)-4-pyridin-3-yl-pyrimidin-2-amine; ANW-41942; BDBM50287093; VCC987289; ZINC21298122; AKOS015909809; AC-2148; ACN-026830; MCULE-9226886591; QC-1117; 112GI008; AK-47893; DS-14539; SC-47708; AB0005259; AM20050826; FT-0654432; M2584; X2637; VU0549313-1; M-8440; 460M098; A809314; J-008922; 2-(2-methyl-5-nitroanilino)-4-(3-pyridinyl)pyrimidine; F9995-0184; N-(2-methyl-5-nitrophenyl)-4-(3-pyridyl)-pyrimidine-amine; N-(2-methyl-5-nitrophenyl)-4-(3-pyridinyl)-2-pyrimidinamine; N-(2-Methyl-5-nitrophenyl)-4-(3-pyridyl)-2-pyrimidinylamine; N-(5-nitro-2-methylphenyl)-4-(3-pyridinyl)-2-pyrimidineamine; (2-Methyl-5-nitro-phenyl)-(4-pyridin-3-yl-pyrimidin-2-yl)-amine; N-(2-Methyl-5-nitrophenyl)-4- (pyridin-3-yl)pyrimidin-2-amine; N-(2-methyl-5-nitrophenyl)-4-(3-pyridinyl)-2 pyrimidine amine; N-(2-methyl-5-nitrophenyl)-4-(3-pyridinyl)-2-pyrimidine amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[84] | |||
| Compound Name |
4-N-[(2-Methoxyphenyl)methyl]pyrido[4,3-d]pyrimidine-4,7-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
7-Aminopyrido[4,3-d]pyrimidine 8k; BDBM3341; CHEMBL121709; N-(2-Methoxybenzyl)pyrido[4,3-d]pyrimidine-4,7-diamine; 7-amino-4-[[(2-methoxyphenyl)-methyl]amino]pyrido[4,3-d]pyrimidine
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[76] | |||
| Compound Name |
4-Amino-3-prop-2-enyl-2-sulfanylidene-N-[(E)-thiophen-2-ylmethylideneamino]-1,3-thiazole-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1944929; BDBM50363485; CCG-237990
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[87] | |||
| Compound Name |
6-(2,4-Dihydroxyphenyl)-2-(4-(furan-2-ylmethylene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)-4-methyl-N-(3-nitrophenyl)-1,6-dihydropyrimidine-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1087440; BDBM50312570
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[111] | |||
| Compound Name |
(Z)-4-Methyl-3-(4-morpholinobenzylidene)indolin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL90277; BDBM50065312; 4-Methyl-3-(4-morpholin-4-yl-benzylidene)-1,3-dihydro-indol-2-one; 4-Methyl-3-[1-(4-morpholin-4-yl-phenyl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
[4-(4-Chloro-phenyl)-pyrimidin-2-yl]-[3-(1,1,2,2-tetrafluoro-ethoxy)-phenyl]-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL57581; SCHEMBL8837820; BDBM50290425; 4-(4-chlorophenyl)-N-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]pyrimidin-2-amine; N-[3-(1,1,2,2-tetrafluoro-ethoxy)-phenyl]-4-(4-chloro-phenyl)-2-pyrimidineamine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(3Z)-3-[(4-Methoxyphenyl)methylidene]-1H-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL87810; 3-(4-Methoxybenzylidene)-2-indolinone; SCHEMBL5475861; BDBM50065296; STL553883; ZINC12339635; AKOS016032064; 3-(4-Methoxybenzylidene)indoline-2-one; (Z)-3-(4-methoxybenzylidene)indolin-2-one; 3-[(Z)-4-Methoxybenzylidene]-1H-indol-2(3H)-one; (3Z)-3-(4-methoxybenzylidene)-1,3-dihydro-2H-indol-2-one; 3-[1-(4-Methoxy-phenyl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
2-Cyano-N-(3-((2-cyano-3-(3,4-dihydroxy-5-(hydroxy(oxido)amino)phenyl)acryloyl)amino)propyl)-3-(3,4-dihydroxy-5-(hydroxy(oxido)amino)phenyl)acrylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
NSC677217; CHEMBL144632; NSC-677217
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[85] | |||
| Compound Name |
Tert-butyl 6-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)quinolin-4-ylcarbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242033
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[43] | |||
| Compound Name |
Methyl 2-{1-methyl-2-[1-methyl-3-(2-methyloxycarbonylphenylcarbamoyl)-1H-2-indolyldisulfanyl]-1H-3-indolylcarboxamido}benzoate0.5 H2O
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL349762; SCHEMBL8999138; BDBM50036022
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[103] | |||
| Compound Name |
N-(4-Bromophenyl)-4-(6,7-dimethoxyquinazolin-4-yl)piperazine-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL323336; SCHEMBL2918427; BDBM50115298; N-(4-bromophenyl)-4-(6,7-dimethoxy-4-quinazolinyl)-1-piperazinecarboxamide; 4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-carboxylic acid (4-bromo-phenyl)-amide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[97] | |||
| Compound Name |
2-Thioxo-1H-indole-3-carboxamide deriv. 14
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL64231; BDBM4048; 2-(benzyldisulfanyl)-1-methyl-N-phenyl-1H-indole-3-carboxamide; 2-(Benzyldithio)-1-methyl-N-phenyl-1H-indole-3-carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[65] | |||
| Compound Name |
4-[(2-Chloroquinazolin-4-yl)amino]-N,N-dimethylbenzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3098314; BDBM50444625
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[74] | |||
| Compound Name |
4-Methyl-3-(5-methylsulfanyl-thiophen-2-ylmethylene)-1,3-dihydro-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL86432; BDBM50065274; 4-Methyl-3-[1-(5-methylsulfanyl-thiophen-2-yl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
(Z)-4-(4-((4-Methyl-2-oxoindolin-3-ylidene)methyl)phenyl)piperazine-1-carbaldehyde
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL89040; BDBM50065290; 4-[4-(4-Methyl-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-phenyl]-piperazine-1-carbaldehyde; 4-{4-[4-Methyl-2-oxo-1,2-dihydro-indol-(3Z)-ylidenemethyl]-phenyl}-piperazine-1-carbaldehyde
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
(3Z)-3-[(4-Chloro-1-methylpyrazol-3-yl)methylidene]-1H-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL89646; SCHEMBL5999800; BDBM50065279; 3-[1-(4-Chloro-1-methyl-1H-pyrazol-3-yl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
3-Substituted indolin-2-one 9a
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SU5402 analog 9a; BDBM4883; CHEMBL147761; SCHEMBL6390802
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
N-(3-Chloro-2-fluorophenyl)-8,9-dimethoxy-2-methyl-5,6-dihydropyrimido[4,5-b][1,4]benzothiazepin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL386579; BDBM50192492
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[75] | |||
| Compound Name |
2-(Benzylsulfonyl)-4-(2,4-dihydroxyphenyl)-6-methyl-N-(3-nitrophenyl)pyrimidine-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1083509; BDBM50312566
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[111] | |||
| Compound Name |
2-[5-(1H-Benzimidazol-2-ylmethyl)-1,3,4-oxadiazol-2-yl]acetonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4067556; BDBM50232335
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[47] | |||
| Compound Name |
3',6-Diamino-7-hydroxyflavone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL115102; 4h-1-benzopyran-4-one,6-amino-2-(3-aminophenyl)-7-hydroxy-; BDBM50037397; ZINC13738769; 6-Amino-2-(3-amino-phenyl)-7-hydroxy-chromen-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[100] | |||
| Compound Name |
1-Isopropyl-3-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL3610353; CHEMBL1241390; US9765037, Compound 16; BDBM340889; 1-propan-2-yl-3-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-amine; 1-isopropyl-3-(pyridin-3-yl)-1H-pyrazolo[3,4- d]pyrimidin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[43] | |||
| Compound Name |
4-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2435077; CHEMBL1242032; 4-(4-amino-1-isopropyl-1h-pyrazolo[3,4-d]pyrimidin-3-yl)benzenesulfonamide; 4-(4-amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)benzenesulfonamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[43] | |||
| Compound Name |
N-(4-Chlorophenyl)-2-[[2-(4-chlorophenyl)-6-oxo-1H-1,3,5-triazin-4-yl]sulfanyl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1946844; ZINC5176597; BDBM50363469; CCG-46357; MCULE-1229698282; SR-01000636060-1
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[87] | |||
| Compound Name |
4',8-Diamino-6-methoxyflavone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL116353; BDBM50037401; 8-Amino-2-(4-amino-phenyl)-6-methoxy-chromen-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[100] | |||
| Compound Name |
4,N*1*-Dimethyl-N*3*-(4-pyridin-3-yl-pyrimidin-2-yl)-benzene-1,3-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL21215; SCHEMBL15159937; BDBM50287095; N1,4-dimethyl-N3-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[84] | |||
| Compound Name |
1-N-(6-Chloro-[1,3]dioxolo[4,5-g]quinazolin-8-yl)-4-N,4-N-dimethylbenzene-1,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3098320; BDBM50444623
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[74] | |||
| Compound Name |
N-[3-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-phenyl]-methanesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2432675; CHEMBL1241948; N-[3-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-phenyl]methanesulfonamide; N-[3-(4-amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)phenyl]methanesulfonamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[43] | |||
| Compound Name |
4-Cyano-N-[3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL58580; SCHEMBL9642; BDBM50290411; VCC015466; 4-Cyano-N-[3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide; 4-Cyano-N-[3-[[4-(3-pyridinyl)pyrimidin-2-yl]amino]phenyl]benzamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
2-(1-Methyl-2-sulfanylidene-3H-indol-3-yl)acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2,3-dihydro-1-methyl-2-thioxo-1H-indole-3-acetic acid; 2-thioxo-1H-indole-3-alkanoic acid deriv. 6; BDBM3957; CHEMBL314416; SCHEMBL1388665; 1-Methyl-2-thioxo-2,3-dihydro-1H-indole-3-acetic acid; 2-(1-methyl-2-sulfanylidene-2,3-dihydro-1H-indol-3-yl)acetic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[61] | |||
| Compound Name |
Tert-butyl N-[4-[[4-(3-chloroanilino)-2H-pyrazolo[3,4-d]pyrimidin-3-yl]amino]phenyl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
4-(Phenylamino)pyrazolo[3,4-d]pyrimidine deriv. 16; BDBM3015; CHEMBL120703; SCHEMBL8124691; 3-((4-(N-BOC-amino)phenyl)amino)-4-((3-chlorophenyl)amino)-1H-pyrazolo[3,4-d]pyrimidine; 3-[4-(N-BOC-amino)-phenylamino]-4-(3-chloro-phenylamino)-1H-pyrazolo[3,4-d]pyrimidine; tert-butyl N-[4-({4-[(3-chlorophenyl)amino]-1H-pyrazolo[3,4-d]pyrimidin-3-yl}amino)phenyl]carbamate
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[112] | |||
| Compound Name |
1-[3-Fluoro-4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinolin-4-yl]oxyphenyl]-3-[(E)-(2-hydroxy-3-prop-2-enylphenyl)methylideneamino]urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3764279; BDBM50147893
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[113] | |||
| Compound Name |
2-Methoxy-6-(decahydronaphthalene-1-ylidenemethyl)-1,4-benzoquinone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL98934; BDBM50130358; 2-Methoxy-6-(octahydro-naphthalen-1-ylidenemethyl)-[1,4]benzoquinone
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[114] | |||
| Compound Name |
Methyl 2-[(2R,3S,4S,6S)-4-[benzoyl(methyl)amino]-3-methoxy-2-methyl-16-oxo-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-17-yl]acetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL131456; BDBM50283911
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[80] | |||
| Compound Name |
4-[(2-Chloro-6,7-dimethoxyquinazolin-4-yl)amino]benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3098324; BDBM50444621
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[74] | |||
| Compound Name |
4-(Dimethylamino)-1-(4-phenylmethoxyphenyl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL543362
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[79] | |||
| Compound Name |
6-Chloro-N-furan-2-ylmethyl-N'-(4-methoxy-phenyl)-[1,3,5]triazine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1348499; ChemDiv1_003076; Oprea1_021843; Oprea1_788423; MLS000562227; HMS595L18; ZINC66917; HMS2183M19; BDBM50363472; CCG-16404; STK757192; ZINC00066917; AKOS000518145; MCULE-9559603689; SMR000174442; ST086774; AG-205/34698030; SR-01000430402; SR-01000430402-1; {6-chloro-4-[(4-methoxyphenyl)amino](1,3,5-triazin-2-yl)}(2-furylmethyl)amine; 6-chloro-N-(furan-2-ylmethyl)-N'-(4-methoxyphenyl)-1,3,5-triazine-2,4-diamine; 6-chloro-N~2~-(2-furylmethyl)-N~4~-(4-methoxyphenyl)-1,3,5-triazine-2,4-diamine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[87] | |||
| Compound Name |
N-Phenyl-4-(pyridin-3-yl)pyrimidin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL57690; N-phenyl-4-pyridin-3-ylpyrimidin-2-amine; SCHEMBL6262145; BDBM50045424; STL122121; ZINC29559018; AKOS005738153; MCULE-6845987679; 4-(3-Pyridinyl)-N-phenylpyrimidin-2-amine; Phenyl-(4-pyridin-3-yl-pyrimidin-2-yl)-amine; N-phenyl-N-[4-(3-pyridyl)-2-pyrimidinyl]amine; Phenyl-(4-pyridin-3-yl-pyrimidin-2-yl)-amine sulphate
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[2] | |||
| Compound Name |
(3E)-3-(Furan-2-ylmethylidene)-1H-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL312826; SCHEMBL20838; HMS1433A06; ZINC4693315; BDBM50065301; IDI1_012097; 3-Furan-2-ylmethylene-1,3-dihydro-indol-2-one; 3-[1-Furan-2-yl-meth-(E)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
2-Benzyl-5-[(6-chloro-1H-benzimidazol-2-yl)methyl]-1,3,4-oxadiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4091284; BDBM50232317
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[47] | |||
| Compound Name |
3-(3,5-Dimethyl-1H-pyrrol-2-ylmethylene)-4-methyl-1,3-dihydro-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL330321; SCHEMBL13432277; BDBM50065288; 3-[1-(3,5-Dimethyl-1H-pyrrol-2-yl)-meth-(Z)-ylidene]-4-methyl-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
Dithiobis(1H-indole-3-carboxamide) deriv. 10j
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM4025; CHEMBL294341; N,N'-Diphenyl[2,2'-dithiobis(5-methoxy-1-methyl-1H-indole-3-carboxamide)]
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[65] | |||
| Compound Name |
Dithiobis(1H-indole-3-carboxamide) deriv. 10m
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL61278; BDBM4028; SCHEMBL8998939; N,N'-Diphenyl[2,2'-dithiobis(5-(trifluoromethyl)-1-methyl-1H-indole-3-carboxamide)]
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[65] | |||
| Compound Name |
N-(1,3-Benzothiazol-6-yl)-8,9-dimethoxy-5,6-dihydropyrimido[4,5-b][1,4]benzothiazepin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL211982; BDBM50192488
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[75] | |||
| Compound Name |
Dithiobis(1H-indole-3-alkanoic acid) deriv. 30
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL314029; BDBM3982; Dimethyl 2,2 -dithiobis(1-methyl-1H-indole-3-propanoate); 2,2'-Dithiobis(1-methyl-1H-indole-3-propanoic acid methyl) ester
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[61] | |||
| Compound Name |
2,3-[Ethyliminobis[ethyleneoxyethylene(1H-indole-1,3-diyl)]]maleimide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL103055; SCHEMBL4346022; BDBM50132310
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[115] | |||
| Compound Name |
Chembl4204920
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50453686
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[116] | |||
| Compound Name |
N-[4-Methoxy-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL21086; BDBM50287088
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[84] | |||
| Compound Name |
5-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)pyridine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2465891; CHEMBL1241772; 5-(4-amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)pyridine-2-carbonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[43] | |||
| Compound Name |
4-N-[(4-Methoxyphenyl)methyl]pyrido[4,3-d]pyrimidine-4,7-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
7-Aminopyrido[4,3-d]pyrimidine 8m; BDBM3343; CHEMBL125995; N-(4-Methoxybenzyl)pyrido[4,3-d]pyrimidine-4,7-diamine; 7-amino-4-[[(4-methoxyphenyl)methyl]-amino]pyrido[4,3-d]pyrimidine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[76] | |||
| Compound Name |
3-(5,6-Dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-benzoic acid ethyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL72976; SCHEMBL2463175; BDBM50051314; ethyl 3-[(5,6-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]benzoate
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
Indolin-2-one deriv. 4c
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL88483; BDBM4906; SCHEMBL5577130; SU-6657; (3Z)-2-oxo-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylidene)-2,3-dihydro-1H-indole-5-sulfonamide; 2-Oxo-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylene)-2,3-dihydro-1H-indole-5-sulfonic acid amide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
Indolin-2-one deriv. 9e
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM4918; CHEMBL420609; SCHEMBL6395500; 2-(6-Methoxy-2-oxo-3-indolinylidenemethyl)-4,5,6,7-tetrahydro-1H-indole-3-propionic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
4-Chloro-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL21162; SCHEMBL9677; BDBM50287090; VCC374125; 4-Chloro-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
6-Fluoro-3-[1-(1H-pyrrol-2-yl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL87208; SCHEMBL5728248; BDBM50065302
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
4',8-Diamino-5-methoxyflavone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL115397; BDBM50037396; 8-Amino-2-(4-amino-phenyl)-5-methoxy-chromen-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[100] | |||
| Compound Name |
2-[(5,13-Diamino-4-thia-8,10,12-triazatricyclo[7.4.0.02,6]trideca-1(13),2,5,7,9,11-hexaen-7-yl)amino]ethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910272; BDBM50356618
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[78] | |||
| Compound Name |
4-(1-Methyl-2-sulfanylidene-3H-indol-3-yl)butanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-thioxo-1H-indole-3-alkanoic acid deriv. 14; CHEMBL83390; BDBM3965; SCHEMBL8998730; 1-Methyl-2-thioxo-2,3-dihydro-1H-indole-3-butyric acid; 2,3-Dihydro-1-methyl-2-thioxo-1H-indole-3-butanoic Acid; 4-(1-methyl-2-sulfanylidene-2,3-dihydro-1H-indol-3-yl)butanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[61] | |||
| Compound Name |
Dithiobis(1H-indole-3-alkanoic acid) deriv. 37
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM3989; CHEMBL419280; Dimethyl 2,2 -Dithiobis(1-methyl-1H-indole-3-butanoate); 2,2'-Dithiobis(1-methyl-1H-indole-3-butanoic acid methyl) ester
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[61] | |||
| Compound Name |
3-(2-Chlorophenyl)-N-[3-fluoro-4-[6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinolin-4-yl]oxyphenyl]-4-methyl-2-oxo-1H-imidazole-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3594105; BDBM50103899
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[117] | |||
| Compound Name |
Cyclohexanecarboxylic acid [3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL58142; SCHEMBL1365; BDBM50290419
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
3-(3-Chlorophenyl)quinoline-4(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL7801; BDBM50074747; ZINC13795472; 3-(3-Chloro-phenyl)-1H-quinolin-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[72] | |||
| Compound Name |
4-(Phenylamino)pyrazolo[3,4-d]pyrimidine deriv. 31
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM3030; CHEMBL334026; 4-(3-chlorophenoxy)-N-(3-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-3-amine; N-(3-Chlorophenyl)-4-(3-chlorophenoxy)-1H-pyrazolo[3,4-d]pyrimidin-3-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[112] | |||
| Compound Name |
Methyl 4-(2-sulfanylidene-1,3-dihydroindol-3-yl)butanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-thioxo-1H-indole-3-alkanoic acid deriv. 15; BDBM3966; CHEMBL312402; SCHEMBL1388280; Methyl 2,3-Dihydro-2-thioxo-1H-indole-3-butanoate; 2-Thioxo-2,3-dihydro-1H-indole-3-butyric acid methyl ester; methyl 4-(2-sulfanylidene-2,3-dihydro-1H-indol-3-yl)butanoate
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[61] | |||
| Compound Name |
5-(4-Amino-1-((piperidin-4-yl)methyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-fluorophenol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242844
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[43] | |||
| Compound Name |
3-(3-Chloro-phenyl)-5-hydroxy-7-methoxy-chromen-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL7339; BDBM50074741; 5-Hydroxy-7-methoxy-3-(3-chlorophenyl)-4H-1-benzopyran-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[72] | |||
| Compound Name |
4',8-Diamino-7-hydroxyflavone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL114568; 4h-1-benzopyran-4-one,8-amino-2-(4-aminophenyl)-7-hydroxy-; BDBM50037407; ZINC13738766; 8-Amino-2-(4-amino-phenyl)-7-hydroxy-chromen-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[100] | |||
| Compound Name |
[2-(3-Benzoyl-1-methyl-1H-indol-2-yldisulfanyl)-1-methyl-1H-indol-3-yl]-phenyl-methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL349322; BDBM50036015
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[103] | |||
| Compound Name |
1,2-Benzenedicarboxylic acid, 4,5-bis(phenylamino)-, dimethyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL8222; ACMC-20mtqs; Dimethyl 4,5-dianilinobenzene-1,2-dicarboxylate; SCHEMBL5809618; CTK0F5690; DTXSID90439446; BDBM50040926; ZINC13735540; 4,5-Dianilinophthalic acid dimethyl ester; DA-34802; 4,5-bis(anilino)phthalic acid dimethylester; FT-0755609; 4,5-Bis(anilino)phthalic acid dimethyl ester; 4,5-Bis(anilino)phthalic acid dim ethyl ester; 4,5-Bis-phenylamino-phthalic acid dimethyl ester
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
1 H-Indole-3-alkanamide deriv. 10m
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM4004; CHEMBL154822; 2,2 -Dithiobis[N-[[3-hydroxy-4-(methoxycarbonyl)phenyl]methyl]-1H-indole-3-propanamide]; 2,2'-Dithiobis[N-(3-hydroxy-4-methoxycarbonylbenzyl)-1H-indole-3-propanamide]
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[59] | |||
| Compound Name |
3-(3,5-Dimethyl-1H-pyrrol-2-ylmethylene)-5-methyl-1,3-dihydro-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL89483; BDBM50065292; (Z)-3-(3,5-Dimethyl-1H-pyrrol-2-ylmethylene)-5-methyl-1,3-dihydro-indol-2-one; 3-[1-(3,5-Dimethyl-1H-pyrrol-2-yl)-meth-(Z)-ylidene]-5-methyl-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
4-[(4-Amino-6-cyanopyrido[2,3-d]pyrimidin-7-yl)amino]benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910270; BDBM50356616
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[78] | |||
| Compound Name |
Methyl 2,3-dihydro-2-thioxo-1H-indole-3-propanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-thioxo-1H-indole-3-alkanoic acid deriv. 11; BDBM3962; CHEMBL309716; SCHEMBL1388675; methyl 3-(2-sulfanylidene-1,3-dihydroindol-3-yl)propanoate; 2-Thioxo-2,3-dihydro-1H-indole-3-propionic acid methyl ester; methyl 3-(2-sulfanylidene-2,3-dihydro-1H-indol-3-yl)propanoate
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[61] | |||
| Compound Name |
3-Substituted indolin-2-one 11h
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SU5402 analog 11h; BDBM4894; CHEMBL148984; SCHEMBL4416055
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
3-[1-(4-Bromo-phenyl)-meth-(Z)-ylidene]-1-methyl-1,3-dihydro-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL314021; ZINC575064; BDBM50065316; AKOS001097016; AB00736582-01; SR-01000072622; SR-01000072622-1
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
4-[[6-Amino-4-butoxy-5-(2,6-difluorobenzoyl)pyridin-2-yl]amino]benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
3-Acyl-2,6-diaminopyridine deriv. 11; BDBM6913; SCHEMBL4551602; CHEMBL2113092; 4-({6-amino-4-butoxy-5-[(2,6-difluorophenyl)carbonyl]pyridin-2-yl}amino)benzene-1-sulfonamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[118] | |||
| Compound Name |
Indolin-2-one deriv. 4g
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM4910; CHEMBL419682; SCHEMBL7838947; 6-(3-methoxyphenyl)-3-(4,5,6,7-tetrahydro-1h-indol-2-ylmethylene)-1,3-dihydroindol-2-one; 6-(3-Methoxyphenyl)-3-[4,5,6,7-tetrahydro-1H-indole-2-ylmethylene]-2-indolinone; (3Z)-6-(3-methoxyphenyl)-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylidene)-2,3-dihydro-1H-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
Dithiobis(1H-indole-3-carboxamide) deriv. 10u
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM4036; CHEMBL291667
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[65] | |||
| Compound Name |
3-((4,5,6,7-Tetrahydro-1H-indol-2-yl)methylene)indolin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
(Z)-3-((4,5,6,7-tetrahydro-1H-indol-2-yl)methylene)indolin-2-one; Indolin-2-one deriv. 4a; BDBM4904; CHEMBL328029; SCHEMBL1062998; SCHEMBL4142256; ZINC4392003; MFCD14586259; AC-31708; DS-20140; CS-0060748; 3-(4,5,6,7-Tetrahydro-1H-indole-2-ylmethylene)-2-indolinone; 3-(4,5,6,7-Tetrahydro-1H-indol-2-ylmethylene)-1,3-dihydroindol-2-one; (3Z)-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylidene)-2,3-dihydro-1H-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
3-Acyl-2,6-diaminopyridine deriv. 2p
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM6896; CHEMBL193456; 4-({6-amino-5-[(2,6-difluorophenyl)carbonyl]pyridin-2-yl}amino)-N,N-dimethylbenzene-1-sulfonamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[118] | |||
| Compound Name |
3-[1-(4-Chloro-1H-pyrazol-3-yl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL87402; SCHEMBL6001442; BDBM50065284
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
N',N'-Dimethyl-N-(5H-pyrimido[5,4-b]indol-4-yl)ethane-1,2-diamine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL543457
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[108] | |||
| Compound Name |
4-[2-Oxo-1,2-dihydro-indol-(3Z)-ylidenemethyl]-benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL313259; BDBM50065281
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
4',8-Diaminoflavone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL323660; 4h-1-benzopyran-4-one,8-amino-2-(4-aminophenyl)-; BDBM50037410; ZINC13738757; 8-Amino-2-(4-amino-phenyl)-chromen-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[100] | |||
| Compound Name |
6-Chloro-N-(4-methylsulfonylphenyl)-[1,3]dioxolo[4,5-g]quinazolin-8-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3098316; BDBM50444624
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[74] | |||
| Compound Name |
(3-Chloro-phenyl)-(2,5,6-trimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL73402; SCHEMBL2461575; BDBM50051298; N-(3-chlorophenyl)-2,5,6-trimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
4-[(6-Chloro-[1,3]dioxolo[4,5-g]quinazolin-8-yl)amino]-N-(1,3-thiazol-2-yl)benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3098311; BDBM50444626
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[74] | |||
| Compound Name |
3-[1-(3,4-Dimethyl-1H-pyrrol-2-yl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL316020; SCHEMBL6001449; BDBM50065311
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
4',8-Diamino-5-hydroxyflavone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL114578; BDBM50037402; 8-Amino-2-(4-amino-phenyl)-5-hydroxy-chromen-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[100] | |||
| Compound Name |
Diselenobis(1H-indole) deriv. 21
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM3352; CHEMBL334973; 2,2 -Diselenobis[1-methyl-1H-indole-3-carboxylic acid, tert-butyl ester]; 2,2'-Diselenobis(1-methyl-1H-indole-3-carboxylic acid tert-butyl) ester
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
N-Cyclohexyl-5H-pyrimido[5,4-b]indol-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Pyrimido[5,4-b]indole deriv. 40; BDBM3749; CHEMBL348003; ZINC13803512; CU-00000000017-1
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[108] | |||
| Compound Name |
Chembl4285414
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50464908
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[119] | |||
| Compound Name |
3-(2-Chloroquinolin-6-yl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL3610356; CHEMBL1241683; 3-(2-chloroquinolin-6-yl)-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[43] | |||
| Compound Name |
N-[3-(4-Pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-isonicotinamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL55592; SCHEMBL1430; BDBM50290421; N-[3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]pyridine-4-carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
1-Ethyl-2-[[1-ethyl-3-(phenylcarbamoyl)indol-2-yl]disulfanyl]-N-phenylindole-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL156020; BDBM50035994; 3N-phenyl-1-ethyl-2-(1-ethyl-3-phenylcarbamoyl-1H-2-indolyldisulfanyl)-1H-3-indolecarboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[103] | |||
| Compound Name |
3-(5-Ethyl-furan-2-ylmethylene)-1,3-dihydro-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL328452; SCHEMBL5728117; BDBM50065291; 3-[1-(5-Ethyl-furan-2-yl)-meth-(E)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
3-(4-Ethoxy-3-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242471; SCHEMBL16665685
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[43] | |||
| Compound Name |
N-(4-Bromophenyl)-8,9-dimethoxy-5,6-dihydropyrimido[4,5-b][1,4]benzoxazepin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL385015; SCHEMBL6255746; BDBM50192484
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[75] | |||
| Compound Name |
4-(3-Chloro-phenylamino)-3-(3-nitro-phenyl)-1H-pyrazolo[3,4-d]pyrimidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM3026; CHEMBL118904; SCHEMBL8115438; ZINC3815230; N-(3-chlorophenyl)-3-(3-nitrophenyl)-2H-pyrazolo[3,4-d]pyrimidin-4-amine; DA-22709; 4-(Phenylamino)pyrazolo[3,4-d]pyrimidine deriv. 27; 3-(3-nitro-phenyl)-4-(3-chloro-phenylamino)-1H-pyrazolo[3,4-d]pyrimidine; 3-(3-Nitrophenyl)-4-((3-chlorophenyl)amino)-1H-pyrazolo[3,4-d]pyrimidine; 3-(3-Nitrophenyl)-N-(3-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; N-(3-chlorophenyl)-3-(3-nitrophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[112] | |||
| Compound Name |
5-(4-Amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-methoxyphenol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1241300
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[43] | |||
| Compound Name |
2-(2-Amino-ethyl-amino)-6-(3-chloro-phenylamino)-9-ethyl-9H-purine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL173647; SCHEMBL5839057; BDBM50073758; 2-N-(2-aminoethyl)-6-N-(3-chlorophenyl)-9-ethylpurine-2,6-diamine; N*2*-(2-Amino-ethyl)-N*6*-(3-chloro-phenyl)-9-ethyl-9H-purine-2,6-diamine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[120] | |||
| Compound Name |
N-(4-Chloro-3-methylphenyl)-8,9-dimethoxy-2-methyl-5,6-dihydropyrimido[4,5-b][1,4]benzothiazepin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL386296; BDBM50192495
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[75] | |||
| Compound Name |
N-(3-Bromophenyl)-8,9-dimethoxy-2-methyl-5,6-dihydropyrimido[4,5-b][1,4]benzoxazepin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL380168; BDBM50192476
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[75] | |||
| Compound Name |
(3Z)-3-[[4-(Dimethylamino)phenyl]methylidene]-6-fluoro-1H-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL329367; BDBM50065298; 3-[1-(4-Dimethylamino-phenyl)-meth-(Z)-ylidene]-6-fluoro-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
N-{4-Methyl-3-[4-(1-oxy-pyridin-3-yl)-pyrimidin-2-ylamino]-phenyl}-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL21079; SCHEMBL3048286; BDBM50287098; N-[4-methyl-3-[[4-(1-oxidopyridin-1-ium-3-yl)pyrimidin-2-yl]amino]phenyl]benzamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[84] | |||
| Compound Name |
(5,6-Dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-m-tolyl-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL307026; SCHEMBL2459209; BDBM50051304; 5,6-dimethyl-N-(3-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
Methyl 3-[4-methyl-5-[(Z)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL316009; SCHEMBL14519114; BDBM50065289
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
4-[5-(1H-Benzimidazol-2-ylmethyl)-1,3,4-oxadiazol-2-yl]phenol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4059610; BDBM50232340
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[47] | |||
| Compound Name |
7-Aminopyrido[4,3-d]pyrimidine 8q
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM3347; CHEMBL419601; N-(2-Dimethylaminobenzyl)pyrido[4,3-d]pyrimidine-4,7-diamine; 4-N-{[2-(dimethylamino)phenyl]methyl}pyrido[4,3-d]pyrimidine-4,7-diamine; 7-amino-4-[[[2-(dimethylamino)phenyl]methyl]amino]pyrido[4,3-d]pyrimidine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[76] | |||
| Compound Name |
2-[5-(1H-Benzimidazol-2-ylmethyl)-1,3,4-oxadiazol-2-yl]benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4073285; BDBM50232338
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[47] | |||
| Compound Name |
(3Z)-3-[(5-Methylsulfanylthiophen-2-yl)methylidene]-1H-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL89721; BDBM50065273; 3-[1-(5-Methylsulfanyl-thiophen-2-yl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
(3Z)-3-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylidene]-6-fluoro-1H-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL87324; BDBM50065282; 3-[1-(3,5-Dimethyl-1H-pyrrol-2-yl)-meth-(Z)-ylidene]-6-fluoro-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
N-Benzyl-2-(2-sulfanylidene-1,3-dihydroindol-3-yl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
1 H-indole-3-alkanamide deriv. 11a; BDBM4013; CHEMBL155389; SCHEMBL1388643; 2,3-Dihydro-2-thioxo-N-benzyl-1H-indole-3-acetamide; N-benzyl-2-(2-sulfanylidene-2,3-dihydro-1H-indol-3-yl)acetamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[59] | |||
| Compound Name |
(3-Nitro-phenyl)-(4-pyridin-4-yl-pyrimidin-2-yl)-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL55683; SCHEMBL1144; BDBM50290426; VCC792768; N-(3-nitrophenyl)-4-pyridin-4-ylpyrimidin-2-amine; 4-(4-Pyridinyl)-N-(3-nitrophenyl)pyrimidin-2-amine; N-(3-nitrophenyl)-4-(4-pyridyl)-2-pyrimidine-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
7,8-Dihydroxyisoquinoline-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL48384; 3-isoquinolinecarboxamide,7,8-dihydroxy-; NSC655246; SCHEMBL9388848; ZINC6500066; BDBM50046762; 7,8-Dihydroxy-3-isoquinolinecarboxamide; 3-Isoquinolinecarboxamide, 7,8-dihydroxy-; 7-hydroxy-8-oxo-2H-isoquinoline-3-carboxamide; 7,8-Dihydroxy-isoquinoline-3-carboxylic acid amide; 7,8-Dihydroxy-3-isoquinolinecarboxamide hydrochloride
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[121] | |||
| Compound Name |
5-[[3-Fluoro-4-[6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinolin-4-yl]oxyphenyl]iminomethyl]-6-hydroxy-1-(4-methylphenyl)pyrimidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3116440; BDBM50446585
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[122] | |||
| Compound Name |
1,3N-Dimethyl-3N-phenyl-2-[1-methyl-3-methyl(phenyl)carbamoyl-1H-2-indolyldisulfanyl]-1H-3-indolecarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL347256; SCHEMBL8999473; BDBM50036006
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[103] | |||
| Compound Name |
Indolin-2-one deriv. 9i
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL91815; BDBM4922; SCHEMBL6393305; 2-[6-(4-Methoxyphenyl)-2-oxo-3-indolinylidenemethyl]-4,5,6,7-tetrahydro-1H-indole-3-propionic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
4-[[6-Amino-5-(2,6-difluorobenzoyl)pyridin-2-yl]amino]benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
3-Acyl-2,6-diaminopyridine deriv. 2r; BDBM6898; CHEMBL193643; SCHEMBL4419524; 4-({6-amino-5-[(2,6-difluorophenyl)carbonyl]pyridin-2-yl}amino)benzene-1-sulfonamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[118] | |||
| Compound Name |
Dithiobis(1H-indole-3-carboxamide) deriv. 10b
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM4017; CHEMBL293986; N,N'-Diphenyl[2,2'-dithiobis(4-chloro-1-methyl-1H-indole-3-carboxamide)]
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[65] | |||
| Compound Name |
3',6-Diaminoflavone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL115103; 4h-1-benzopyran-4-one,6-amino-2-(3-aminophenyl)-; BDBM50037399; ZINC13738768; 6-Amino-2-(3-amino-phenyl)-chromen-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[100] | |||
| Compound Name |
3-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2469784; CHEMBL1242031; 3-(4-amino-1-isopropyl-1h-pyrazolo[3,4-d]pyrimidin-3-yl)benzenesulfonamide; 3-(4-amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)benzenesulfonamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[43] | |||
| Compound Name |
5-Chloro-3-(1H-pyrrol-2-ylmethylene)-1,3-dihydro-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL431025; SCHEMBL3912682; BDBM50065317; ZINC33034247; AKOS001473500; 5-Chloro-3-[1-(1H-pyrrol-2-yl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
2-[3-Fluoro-4-[6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinolin-4-yl]oxyphenyl]-N-[(E)-[4-(trifluoromethyl)phenyl]methylideneamino]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3339360; BDBM50102822
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[123] | |||
| Compound Name |
3-Substituted indolin-2-one 11f
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SU5402 analog 11f; BDBM4892; CHEMBL148514; SCHEMBL4408863
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
5-Benzyl-4-methyl-2-[(3-naphthalen-2-yloxy-2-oxopropyl)amino]thiophene-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1944924; BDBM50363480
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[87] | |||
| Compound Name |
4-Methyl-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL20867; SCHEMBL9820; BDBM50175491; VCC643561; 4-Methyl-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Schembl22498984
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4083305; BDBM50232334
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[47] | |||
| Compound Name |
3-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2434145; CHEMBL1241679; 3-(4-amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)benzonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[43] | |||
| Compound Name |
4',6,8-Triaminoflavone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL112422; BDBM50037394; 6,8-Diamino-2-(4-amino-phenyl)-chromen-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[100] | |||
| Compound Name |
4-Amino-2,7-bis(2-hydroxyethylamino)pyrido[2,3-d]pyrimidine-6-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910274; BDBM50356620
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[78] | |||
| Compound Name |
Indolin-2-one deriv. 9a
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM4914; CHEMBL315753; SCHEMBL6297812; 2-(2-Oxo-3-indolinylidenemethyl)-4,5,6,7-tetrahydro-1H-indole-3-propionic acid; 3-[2-(2-Oxo-1,2-dihydroindol-3-ylidenemethyl)-4,5,6,7-tetrahydro-1H-indol-3-yl]propionic Acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
6,7-Dihydroxyisoquinoline-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
3-isoquinolinecarboxamide,6,7-dihydroxy-; CHEMBL295939; NSC655245; 7-hydroxy-6-oxo-2,6-dihydroisoquinoline-3-carboxamide; SCHEMBL9386706; CTK7D2490; ZINC6499802; BDBM50046760; 6,7-Dihydroxy-3-isoquinolinecarboxamide; 3-Isoquinolinecarboxamide, 6,7-dihydroxy-; 6,7-Dihydroxy-isoquinoline-3-carboxylic acid amide; 6,7-Dihydroxy-3-isoquinolinecarboxamide hydrochloride
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[121] | |||
| Compound Name |
3-[1-(4-Pyrrolidin-1-yl-phenyl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL314217; SCHEMBL6001567; SCHEMBL14519135; ZINC574986; BDBM50065314
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
Indolin-2-one deriv. 4e
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL91250; BDBM4908; 6-Methoxy-3-(4,5,6,7-tetrahydro-1H-indole-2-ylmethylene)-2-indolinone; 6-Methoxy-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylene)-1,3-dihydroindol-2-one; (3Z)-6-methoxy-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylidene)-2,3-dihydro-1H-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
(3Z)-3-[(1-Methylpyrrol-2-yl)methylidene]-1H-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL86631; SCHEMBL21465; BDBM50065300; 3-[1-(1-Methyl-1H-pyrrol-2-yl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
Dimeric Tyrphostin 21
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM5163; CHEMBL143108; N,N'-(Propane-1,3-diyl)bis[(E)-2-cyano-3-(1H-indol-5-yl)acrylamide]
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[85] | |||
| Compound Name |
N-[4-Methyl-3-(4-thiophen-2-yl-pyrimidin-2-ylamino)-phenyl]-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL21078; BDBM50287087
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[84] | |||
| Compound Name |
2-(4-p-Tolyl-1H-1,2,3-triazol-1-yl)cyclohexanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1642294; BDBM50334629
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[124] | |||
| Compound Name |
5-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-fluorobenzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL3608290; CHEMBL1241680; 5-(4-amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)-2-fluorobenzonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[43] | |||
| Compound Name |
Dithiobis(1H-indole-3-carboxamide) deriv. 10v
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL64165; BDBM4037; N,N'-Diphenyl[2,2'-dithiobis(1,7-dimethyl-1H-indole-3-carboxamide)]
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[65] | |||
| Compound Name |
Indolin-2-one deriv. 9f
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL88771; BDBM4919; SCHEMBL6389192; 2-(6-Phenyl-2-oxo-3-indolinylidenemethyl)-4,5,6,7-tetrahydro-1H-indole-3-propionic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
N-(3-Chloro-4-(3-fluorobenzyloxy)phenyl)-6-(pyrrolidin-1-yl)pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683953; BDBM50338607
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[125] | |||
| Compound Name |
2-[(6-Chloro-1H-benzimidazol-2-yl)methyl]-5-phenyl-1,3,4-oxadiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4063427; BDBM50232318
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[47] | |||
| Compound Name |
(Z)-3-(2,4-Dimethyl-5-((2-oxo-6-phenylindolin-3-ylidene)methyl)-1H-pyrrol-3-yl)propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SU 16F; CHEMBL149201; SU-16F; 3-substituted indolin-2-one 16f; BDBM4900; SCHEMBL4408682; ZINC3834020; AKOS015994588; ES-0059; NCGC00370874-01; HY-108628; CS-0029344; J-015830; PDGFR Tyrosine Kinase Inhibitor VII - CAS 251356-45-3
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4,5-Bis(4-fluoroanilino)phthalic acid dimethyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL8091; SCHEMBL8834288; BDBM50040931; 4,5-bis(4-fluoroanilino)phthalic acid dimethylester; 4,5-bis-(4-fluoroanilino)phthalic acid dimethylester; dimethyl 4,5-bis(4-fluoroanilino)benzene-1,2-dicarboxylate; 4,5-Bis-(4-fluoro-phenylamino)-phthalic acid dimethyl ester
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
(3Z)-3-[(3-Ethyl-4,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1H-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL313433; SCHEMBL6000845; BDBM50065303; 3-[1-(3-Ethyl-4,5-dimethyl-1H-pyrrol-2-yl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
4-(6,7-Dimethoxyquinazolin-4-yl)-N-thiophen-3-ylpiperazine-1-carboxamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL553824
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[104] | |||
| Compound Name |
Chembl4276946
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
GTPL9965; compound 3a [Pipionne et al, 2018]; 1-[5-amino-4-(3,4-dichlorophenyl)-3-methyl-1H-pyrazol-1-yl]ethan-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[126] | |||
| Compound Name |
5-Chloro-1-methyl-N-phenyl-2-sulfanylidene-3H-indole-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-thioxo-1H-indole-3-carboxamide deriv. 9g; CHEMBL62067; BDBM4043; 2,3-Dihydro-5-chloro-1-methyl-2-thioxo-N-phenyl-1H-indole-3-carboxamide; 5-chloro-1-methyl-N-phenyl-2-sulfanylidene-2,3-dihydro-1H-indole-3-carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[65] | |||
| Compound Name |
4-(3,4-Dimethoxy-phenoxy)-6,7-dimethoxy-quinazoline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL431818; BDBM50290837
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[18] | |||
| Compound Name |
5-(2,5-Dimethoxy-benzylamino)-2-hydroxy-benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL341459; SCHEMBL4823681; BDBM50038197; ZINC13739790; 5-[(2,5-dimethoxyphenyl)methylamino]-2-hydroxybenzoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[99] | |||
| Compound Name |
4-(6,7-Dimethoxy-4-quinazolinyl)-N-(3,4-methylenedioxybenzyl)-1-piperazinethiocarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL102301; SCHEMBL2923651; KN734; BDBM50118826; KN-734; N-(1,3-benzodioxol-5-ylmethyl)-4-(6,7-dimethoxyquinazolin-4-yl)piperazine-1-carbothioamide; 4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-carbothioic acid (benzo[1,3]dioxol-5-ylmethyl)-amide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[104] | |||
| Compound Name |
Methyl 4-(1-methyl-2-sulfanylidene-3H-indol-3-yl)butanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-thioxo-1H-indole-3-alkanoic acid deriv. 16; CHEMBL84512; BDBM3967; SCHEMBL1388508; Methyl 2,3-Dihydro-1-methyl-2-thioxo-1H-indole-3-butanoate; 1-Methyl-2-thioxo-2,3-dihydro-1H-indole-3-butyric acid methyl ester; methyl 4-(1-methyl-2-sulfanylidene-2,3-dihydro-1H-indol-3-yl)butanoate
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[61] | |||
| Compound Name |
3',8-Diamino-6-methoxyflavone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL114550; BDBM50037392; 8-Amino-2-(3-amino-phenyl)-6-methoxy-chromen-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[100] | |||
| Compound Name |
5-(4-Amino-1-((R)-1-aminopropan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-fluorophenol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242378
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[43] | |||
| Compound Name |
N-(2-Chloro-4-fluorophenyl)-8,9-dimethoxy-5,6-dihydropyrimido[4,5-b][1,4]benzoxazepin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL384558; BDBM50192493
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[75] | |||
| Compound Name |
(3-Chloro-phenyl)-(4-pyridin-3-yl-pyrimidin-2-yl)-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL300817; SCHEMBL6254782; BDBM50045485; ZINC29559022; 4-(3-Pyridinyl)-N-(3-chlorophenyl)pyrimidin-2-amine; N-(3-chlorophenyl)-4-pyridin-3-ylpyrimidin-2-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Tert-butyl N-[(2R)-1-oxo-1-[[4-[3-(trifluoromethyl)anilino]quinazolin-6-yl]amino]propan-2-yl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4102666; BDBM50237663
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[101] | |||
| Compound Name |
(3Z)-3-[(5-Bromo-4,5,6,7-tetrahydro-1H-indol-2-yl)methylidene]-1H-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL408565; BDBM50375652
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
1-Methyl-2-[[1-methyl-3-(pyridin-4-ylcarbamoyl)indol-2-yl]disulfanyl]-N-pyridin-4-ylindole-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL156281; SCHEMBL8998915; BDBM50036002
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[103] | |||
| Compound Name |
(3Z)-3-[(4-Ethyl-3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1H-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL420411; SCHEMBL5728018; BDBM50065286; 3-[1-(4-Ethyl-3,5-dimethyl-1H-pyrrol-2-yl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
5-(4-Amino-1-((4-phenyloxazol-5-yl)methyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-fluorophenol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1241482
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[43] | |||
| Compound Name |
N-(4-Chloro-phenyl)-6-methoxy-N'-(2-morpholin-4-yl-ethyl)-[1,3,5]triazine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1946846; ChemDiv1_017828; Oprea1_148711; HMS637K08; BDBM50363471; STK755852; ZINC19758216; AKOS005615763; MCULE-4335193234; AB00092816-01; SR-01000516239; SR-01000516239-1; N-[4-(4-chloroanilino)-6-methoxy-1,3,5-triazin-2-yl]-N-(2-morpholinoethyl)amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[87] | |||
| Compound Name |
3-(3-Bromo-5-tert-butyl-4-methoxy-benzylidene)-5-chloro-1,3-dihydro-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL86944; BDBM50065313; 3-[1-(3-Bromo-5-tert-butyl-4-methoxy-phenyl)-meth-(Z)-ylidene]-5-chloro-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
3-Substituted indolin-2-one 9c
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SU5402 analog 9c; BDBM4885; CHEMBL450622; SCHEMBL6396784
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(5,6-Dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-phenyl-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL75049; SCHEMBL2461344; BDBM50051319; 5,6-dimethyl-N-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
2-(1H-Benzimidazol-2-ylmethyl)-5-(4-methylphenyl)-1,3,4-oxadiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4086731; BDBM50232331
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[47] | |||
| Compound Name |
5-(1H-Indol-3-yl)-3-(3,4,5-trimethoxyphenyl)-1H-pyrazin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3358966
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[127] | |||
| Compound Name |
10-Hydroxy-18-N-2-naphthyl-N-phenylaminobetaenone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL443169; BDBM50269145; 10-Hydroxy-18-N-2-naphtyl-N-phenylaminobetae- none
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[128] | |||
| Compound Name |
Indolin-2-one deriv. 4d
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL89010; BDBM4907; 2-Oxo-3-(4,5,6,7-tetrahydro-1H-indole-2-ylmethylene)indoline-5-carboxylic acid; (3Z)-2-oxo-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylidene)-2,3-dihydro-1H-indole-5-carboxylic acid; 2-Oxo-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylene)-2,3-dihydro-1H-indole-5-carboxylic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
4',8-Diamino-6-hydroxyflavone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL112421; BDBM50037406; 8-Amino-2-(4-amino-phenyl)-6-hydroxy-chromen-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[100] | |||
| Compound Name |
N-[(2R,3S,4S,6S)-17-Benzyl-3-methoxy-2-methyl-16-oxo-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-4-yl]-N-methylbenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL415233; BDBM50283914
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[80] | |||
| Compound Name |
1 H-Indole-3-alkanamide deriv. 10u
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM4012; CHEMBL156555; 2,2'-Dithiobis(N-benzyl-1H-indole-3-butanamide); N-benzyl-4-[2-({3-[3-(benzylcarbamoyl)propyl]-1H-indol-2-yl}disulfanyl)-1H-indol-3-yl]butanamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[59] | |||
| Compound Name |
4-Methyl-5-[2-oxo-1,2-dihydro-indol-(3Z)-ylidenemethyl]-1H-pyrrole-3-carboxylic acid ethyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL316008; SCHEMBL5388917; BDBM50065283
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
4-[[4-Amino-6-cyano-2-(2-hydroxyethylamino)-5-methylpyrido[2,3-d]pyrimidin-7-yl]amino]benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910277; BDBM50356623
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[78] | |||
| Compound Name |
2-Methoxy-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL418010; SCHEMBL9666; BDBM50287096; VCC863136; 2-Methoxy-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
2-(1H-Benzimidazol-2-ylmethyl)-5-thiophen-2-yl-1,3,4-oxadiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4075892; BDBM50232332
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[47] | |||
| Compound Name |
4',5,7-Triamino-6-hydroxyflavone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL114814; CTK4C9734; 5,7,4'-triamino-6-hydroxyflavone; BDBM50037395; 5,7-Diamino-2-(4-amino-phenyl)-6-hydroxy-chromen-4-one; 4H-1-Benzopyran-4-one,5,7-diamino-2-(4-aminophenyl)-6-hydroxy-, hydrochloride (1:3)
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[100] | |||
| Compound Name |
N,N'-(Butane-1,4-diyl)bis[(E)-2-cyano-3-(3-bromo-4-hydroxy-5-methoxyphenyl)acrylamide]
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL357400
Click to Show/Hide
|
||||
| Activity |
IC50 = 102000 nM
|
[85] | |||
| Compound Name |
4-N-(3-Chloro-4-fluorophenyl)-6-(2-pyridin-2-ylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2335378; BDBM50429673
Click to Show/Hide
|
||||
| Activity |
IC50 = 110600 nM
|
[92] | |||
| Compound Name |
5-[2-(2-Methoxyphenyl)-3-methylbut-1-enyl]furo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL594810
Click to Show/Hide
|
||||
| Activity |
IC50 = 111400 nM
|
[53] | |||
| Compound Name |
4-N-(4-Chloro-2-fluorophenyl)-6-(naphthalen-1-ylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1929554; BDBM50360176
Click to Show/Hide
|
||||
| Activity |
IC50 = 112100 nM
|
[49] | |||
| Compound Name |
4-N-(4-Chloro-2-fluorophenyl)-6-[(2,5-dimethoxyphenyl)methyl]-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1929556; BDBM50360178
Click to Show/Hide
|
||||
| Activity |
IC50 = 112700 nM
|
[49] | |||
| Compound Name |
(E)-2-Cyano-N-[2-[[(E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enoyl]amino]ethyl]-3-(3,4-dihydroxyphenyl)prop-2-enamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL144908; Dimeric Tyrphostin 3; Tirfostin; BDBM5150; SCHEMBL6217616; SCHEMBL8486593; N,N'-Ethylenebis[(E)-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide]
Click to Show/Hide
|
||||
| Activity |
IC50 = 113000 nM
|
[85] | |||
| Compound Name |
4-N-(3-Bromophenyl)-7-[(2-methylphenyl)methyl]pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956889; BDBM50366089
Click to Show/Hide
|
||||
| Activity |
IC50 = 113300 nM
|
[25] | |||
| Compound Name |
N-(4-Anilino-5-chloro-9H-pyrimido[4,5-b]indol-2-yl)-2,2-dimethylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2337367; BDBM50430566
Click to Show/Hide
|
||||
| Activity |
IC50 = 114700 nM
|
[8] | |||
| Compound Name |
Piperonylidenemalononitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
MALONONITRILE, (PIPERONYLIDENE)-; (Benzo[3,4-d]1,3-dioxolan-5-ylmethylene)methane-1,1-dicarbonitrile; 2-(1,3-benzodioxol-5-ylmethylidene)propanedinitrile; 2-(Benzo[d][1,3]dioxol-5-ylmethylene)malononitrile; Propanedinitrile,2-(1,3-benzodioxol-5-ylmethylene)-; 2-(1,3-benzodioxol-5-ylmethylene)malononitrile; 2-(2H-1,3-benzodioxol-5-ylmethylidene)propanedinitrile; NSC 1340; NSC 521577; BRN 0181717; (2H-benzo[3,4-d]1,3-dioxolen-5-ylmethylene)methane-1,1-dicarbonitrile; Maybridge1_007110; Oprea1_083830; Oprea1_282990; 5-19-07-00480 (Beilstein Handbook Reference); CHEMBL78005; BDBM4330; SCHEMBL3369590; CTK4G3732; HMS561L04; ZINC51261; DTXSID50183872; NSC1340; NSC-1340; (Benzo[3,4-D]1,3-Dioxolan-5-Yl-Methylene)Methane-1,1-Dicarbonitrile; MFCD00022987; NSC521577; SBB038644; STK028870; AKOS000266877; MCULE-3873660958; NSC-521577; benzylidenemalononitrile (BMN) deriv. 14; ST090382; DB-047637; FT-0634583; KS-00003531; 2-Benzo[1,3]dioxol-5-ylmethylene-malononitrile; (1,3-benzodioxol-5-ylmethylidene)propanedinitrile; 2X-0244; 2-((benzo[d][1,3]dioxol-5-yl)methylene)malononitrile; 2-[(2H-1,3-benzodioxol-5-yl)methylidene]propanedinitrile; (Benzo[3,4-d]1,3-dioxolan-5-ylmethylene)-methane-1,1-dicarbonitrile
Click to Show/Hide
|
||||
| Activity |
Ki = 117000 nM
|
[30] | |||
| Compound Name |
N4-(4-Fluoro-3-(trifluoromethyl)phenyl)-6-phenethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL482715; BDBM50271852; N4-[4-Fluoro-3-(trifluoromethyl)phenyl]-6-(2-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
||||
| Activity |
IC50 = 122000 nM
|
[70] | |||
| Compound Name |
(3-Hydroxybenzylidene)propanedinitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-[(3-hydroxyphenyl)methylidene]propanedinitrile; m-Hydroxybenzylidenemalononitrile; NSC74439; NCIOpen2_000626; BDBM4329; CHEMBL310400; SCHEMBL8543873; 3-Hydroxybenzylidenemalononitrile; CTK5D6477; DTXSID10291245; ZINC1620775; BBL006910; MCK100550; MFCD01162200; NSC-74439; STL137024; 2-(3-Hydroxybenzylidene)malononitrile; AKOS002952566; MCULE-9500307588; 2-(3-Hydroxy-benzylidene)-malononitrile; benzylidenemalononitrile (BMN) deriv. 13; H1162; V2230; F0192-0862; PROPANEDINITRILE, 2-[(3-HYDROXYPHENYL)METHYLENE]-
Click to Show/Hide
|
||||
| Activity |
Ki = 123000 nM
|
[30] | |||
| Compound Name |
Propanedinitrile, ((4-hydroxy-3-nitrophenyl)methylene)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
AG 127; 2-[(4-hydroxy-3-nitrophenyl)methylidene]propanedinitrile; AG127; benzylidenemalononitrile (BMN) deriv. 19; Oprea1_459053; BDBM4335; CHEMBL308134; Propanedinitrile, 2-[(4-hydroxy-3-nitrophenyl)methylene]-; MCK100183; ZINC14944535; AKOS002952030
Click to Show/Hide
|
||||
| Activity |
IC50 = 125000 nM
|
[30] | |||
| Compound Name |
2-(4-Hydroxyphenyl)benzothiazol-6-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL44227; 6-Benzothiazolol,2-(4-hydroxyphenyl)-; SCHEMBL5423269; BDBM50407168; 2-(p-hydroxyphenyl)-6-hydroxybenzothiazole; 2-(4-Hydroxy-phenyl)-6-hydroxy-benzothiazole; 4-(6-hydroxy-3H-1,3-benzothiazol-2-ylidene)cyclohexa-2,5-dien-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 130000 nM
|
[9] | |||
| Compound Name |
2-(3,4-Dihydroxyphenyl)benzothiazole-4,6-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL48085; BDBM50407166
Click to Show/Hide
|
||||
| Activity |
IC50 = 130000 nM
|
[9] | |||
| Compound Name |
N-[4-(3-Bromoanilino)-3-cyanoquinolin-6-yl]-4-(propylamino)but-2-ynamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2262407; SCHEMBL6998273; BDBM50487308
Click to Show/Hide
|
||||
| Activity |
IC50 = 130016.96 nM
|
[93] | |||
| Compound Name |
N-[5-Chloro-4-(3-methoxyanilino)-9H-pyrimido[4,5-b]indol-2-yl]-2,2-dimethylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2337372; BDBM50430561
Click to Show/Hide
|
||||
| Activity |
IC50 = 130500 nM
|
[8] | |||
| Compound Name |
4-Formyl-alpha-cyanocinnamic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
benzylidenemalononitrile (BMN) deriv. 35; CHEMBL76985; BDBM4351; (2E)-2-cyano-3-(4-formylphenyl)prop-2-enoic acid
Click to Show/Hide
|
||||
| Activity |
Ki = 140000 nM
|
[30] | |||
| Compound Name |
Benzoic acid, 4-(2,2-dicyanoethenyl)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
4-(2,2-dicyanoeth-1-en-1-yl)benzoic acid; 4-(2,2-dicyanoethenyl)benzoic acid; benzylidenemalononitrile (BMN) deriv. 12; Oprea1_449829; CHEMBL78174; BDBM4328; SCHEMBL4910902; CTK0E7330; DTXSID50416172; 4-(2,2-Dicyanovinyl)benzoic acid; ZINC14944534; AKOS002951404
Click to Show/Hide
|
||||
| Activity |
Ki = 143000 nM
|
[30] | |||
| Compound Name |
4-N-(3-Bromophenyl)-6-[(2,5-dimethoxyphenyl)methyl]-4-N-methyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1254444; BDBM50326615; 2-Amino-4-(N-methyl-m-bromoanilino)-6-(2,5-dimethoxybenzyl)-pyrrolo[2,3-d]pyrimidine
Click to Show/Hide
|
||||
| Activity |
IC50 = 143500 nM
|
[62] | |||
| Compound Name |
2-Propenamide, N-[5-[(5-chloro-4-pyrazolo[1,5-a]pyridin-3-yl-2-pyrimidinyl)amino]-2-[[2-(dimethylamino)ethyl]methylamino]-4-methoxyphenyl]-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3353404; SCHEMBL16669316; BDBM50029685
Click to Show/Hide
|
||||
| Activity |
IC50 = 145000 nM
|
[71] | |||
| Compound Name |
(4-(1-Carboxyethen-2-yl)benzylidene)malononitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
(E)-3-[4-(2,2-dicyanoethenyl)phenyl]prop-2-enoic acid; Cinnbzmeprcn2; Tyrphostin 11; CHEMBL77778; BDBM4327; SCHEMBL19716206; ((4-(1-Carboxyethen-2-yl)phenyl)methylene)propanedinitrile; ZINC6092604; benzylidenemalononitrile (BMN) deriv. 11; 2-Propenoic acid, 3-(4-(2,2-dicyanoethenyl)phenyl)-; (2E)-3-[4-(2,2-dicyanoeth-1-en-1-yl)phenyl]prop-2-enoic acid
Click to Show/Hide
|
||||
| Activity |
Ki = 150000 nM
|
[30] | |||
| Compound Name |
N-Tert-butyl-3-[[5-cyano-2-[3-methyl-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]amino]benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3885292; BDBM50208591
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 150000 nM
|
[96] | |||
| Compound Name |
1-[3-(Cyclohexylamino)-8-thia-4,6,11-triazatricyclo[7.4.0.02,7]trideca-1(9),2,4,6-tetraen-11-yl]prop-2-en-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3133900
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 150000 nM
|
[63] | |||
| Compound Name |
2-N-[3-Methyl-4-(4-methylpiperazin-1-yl)phenyl]-4-N-(3-methylphenyl)pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3884848; BDBM50208589
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 150000 nM
|
[96] | |||
| Compound Name |
3-[[2-[3-Methyl-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]amino]benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3884104; BDBM50208590
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 150000 nM
|
[96] | |||
| Compound Name |
Tyrphostin AG 126
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
AG-126; AG 126; ag126; alpha-Cyano-(3-hydroxy-4-nitro)cinnamonitrile; Tyrphostin AG126; UNII-7YA4AMD1JC; 2-[(3-hydroxy-4-nitrophenyl)methylidene]propanedinitrile; 7YA4AMD1JC; Propanedinitrile, ((3-hydroxy-4-nitrophenyl)methylene)-; Propanedinitrile,2-[(3-hydroxy-4-nitrophenyl)methylene]-; 2-(3-hydroxy-4-nitrobenzylidene)malononitrile; (3-Hydroxy-4-nitrobenzylidene)malononitrile; Tyrphostin A 10; SR-01000076182; tyrphostin AG-126; ACMC-20dhp9; BiomolKI_000026; Lopac-T-9177; BiomolKI2_000034; UPCMLD-DP015; Lopac0_001272; BMK1-D2; BSPBio_001196; KBioGR_000536; KBioSS_000536; CHEMBL77387; AG126;Tyrphostin AG 126; BDBM4326; SCHEMBL1802883; UPCMLD-DP015:001; UPCMLD-DP015:002; CTK4B0663; KBio2_000536; KBio2_003104; KBio2_005672; KBio3_000971; KBio3_000972; DTXSID80152117; Bio2_000438; Bio2_000918; HMS1362L17; HMS1792L17; HMS1990L17; HMS3403L17; HMS3648K20; BCP29141; ZINC2560269; HSCI1_000134; MCK100790; s6596; CCG-100630; CS-8032; IDI1_002193; NCGC00016062-01; NCGC00016062-02; NCGC00016062-03; NCGC00016062-04; NCGC00016062-05; NCGC00016062-06; NCGC00016062-07; NCGC00094508-01; NCGC00094508-03; NCGC00094508-04; NCGC00094508-05; NCGC00094508-06; NCGC00094508-07; benzylidenemalononitrile (BMN) deriv. 10; BS-14518; HY-108330; AK00064474; EU-0101272; T 9177; J-003748; SR-01000076182-1; SR-01000076182-4; AG 126 - CAS 118409-62-4; BRD-K67506692-001-03-8; BRD-K67506692-001-04-6; Q27166506; Propanedinitrile, 2-[(3-hydroxy-4-nitrophenyl)methylene]-
Click to Show/Hide
|
||||
| Activity |
Ki = 150000 nM
|
[30] | |||
| Compound Name |
4-((2s)-2-Methoxymethylpyrrolidin-1-yl)but-2-ynoic acid[4-(3-bromophenylamino)-3-cyanoquinolin-6-yl]amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL117324; SCHEMBL1896371; BDBM50148236; N-[4-(3-bromoanilino)-3-cyanoquinolin-6-yl]-4-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]but-2-ynamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 150003.02 nM
|
[93] | |||
| Compound Name |
Malonoben
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
tyrphostin A9; Tyrphostin 9; NSC 242557; GCP 5126; ENT 27910; SF 6847; AG 17; UNII-87TE8MRS65; S-15126; 3,5-di-t-Butyl-4-hydroxy-benzylidenemalononitrile; Tyrphostin 9 (RG-50872, Malonaben, SF 6847); MLS002702095; 87TE8MRS65; GCP5126; MFCD00209853; NSC242557; Malonoben [ANSI]; Caswell No. 291AA; Gulf S-15126; SMR001230759; RG-50872; Tyrphostin 9/AG-9; Malonoben [ANSI:ISO]; EPA Pesticide Chemical Code 537200; BRN 2700764; Malonaben; AI3-27910; Tyrphostin AG 17; Tyrphostin 9AG-17; Tyrphostin A9, solid; TYRPHOSTINA9; Lopac-T-182; BiomolKI_000020; BiomolKI2_000009; Neuro_000115; CBiol_001719; Lopac0_001254; Oprea1_168738; BMK1-C8; BSPBio_001200; KBioGR_000540; KBioSS_000540; 4-10-00-02178 (Beilstein Handbook Reference); MLS002153354; CHEMBL78150; SCHEMBL120440; Tyrphostin 9 (SF 6847); BDBM4325; ZINC5256; DTXSID1042106; CTK8G3674; KBio2_000540; KBio2_003108; KBio2_005676; KBio3_000979; KBio3_000980; KS-00000XPI; Bio1_000005; Bio1_000494; Bio1_000983; Bio2_000440; Bio2_000920; HMS1362L21; HMS1792L21; HMS1990L21; HMS2232D08; HMS3263L10; HMS3371F08; HMS3403L21; HMS3651J06; BCP06486; Tox21_501254; HSCI1_000185; MCK103008; s2895; STL406446; AKOS024319213; CCG-100624; CS-1033; LP01254; MCULE-2226202492; NSC-242557; QC-1143; SDCCGSBI-0051221.P002; SF-6847; IDI1_002195; benzylidenemalononitrile (BMN) deriv. 9; NCGC00015992-01; NCGC00015992-02; NCGC00015992-03; NCGC00015992-04; NCGC00015992-05; NCGC00015992-06; NCGC00015992-07; NCGC00094494-01; NCGC00094494-02; NCGC00094494-03; NCGC00094494-04; NCGC00094494-05; NCGC00261939-01; AC-32053; HY-15511; NCI60_001943; SF 6847;RG-50872; AB0035909; EU-0101254; SW219498-1; T-182; Y0356; A11949; C19039; S-7671; 2,6-Di-tert-butyl-4-(2,2-dicyanovinyl)phenol; AG 17 - CAS 10537-47-0; SR-01000075534; J-001407; J-524054; SR-01000075534-1; BRD-K40255344-001-04-4; BRD-K40255344-001-05-1; Q27155778
Click to Show/Hide
|
||||
| Activity |
Ki = 155000 nM
|
[30] | |||
| Compound Name |
7,8-Dimethoxy-3-methyl-5,10-dihydro-3H-pyrimido[4,5-b]quinolin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL6976; BDBM50286752
Click to Show/Hide
|
||||
| Activity |
IC50 = 160000 nM
|
[83] | |||
| Compound Name |
4-Hydroxybenzylidenemalononitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Tyrphostin 8; 2-[(4-hydroxyphenyl)methylidene]propanedinitrile; Malononitrile, (p-hydroxybenzylidene)-; UKI2IW0CAY; UNII-UKI2IW0CAY; 2-(4-hydroxybenzylidene)malononitrile; [(4-hydroxyphenyl)methylene]malononitrile; propanedinitrile, [(4-hydroxyphenyl)methylene]-; (4-Hydroxybenzylidene)malononitrile; MFCD00020189; (4-hydroxybenzylidene)propanedinitrile; Propanedinitrile, ((4-hydroxyphenyl)methylene)- (9CI); ((4-Hydroxyphenyl)methylene)malononitrile; 2-[(4-HYDROXYPHENYL)METHYLENE]MALONONITRILE; 4-Hydroxybenzylidene malononitrile; NSC 1345; EINECS 223-253-0; 4-Hydroxy-benzal-malonitril [German]; [(4-hydroxyphenyl)methylene]methane-1,1-dicarbonitrile; 4-Hydroxy-benzal-malonitril; BRN 2209079; Tyrphostin-8; F 2372; ACMC-1CTU5; 2-Hydroxybenzalmalononitrile; WLN: QR D1UYCN&CN; BSPBio_001199; KBioGR_000539; KBioSS_000539; 4-(2,2'-dicyanovinyl)phenol; BDBM4324; BMK1-H11; CHEMBL305695; SCHEMBL1238796; RARECHEM AL BX 0098; CTK7C4442; KBio2_000539; KBio2_003107; KBio2_005675; KBio3_000977; KBio3_000978; DTXSID80191283; NSC1345; Bio2_000430; Bio2_000910; HMS1362K21; HMS1792K21; HMS1990K21; HMS3403K21; ZINC149333; NSC-1345; STR04828; BBL008143; HSCI1_000080; MCK103087; PR-113; SBB043856; STL139246; 4-hydroxyphenylmethylene malononitrile; 2-(4-Hydroxy-benzyliden)-malonitrile; AKOS000274430; MCULE-8226882576; 2-(4-hydroxylbenzylidene)-malononitrile; IDI1_002185; benzylidenemalononitrile (BMN) deriv. 8; NCGC00163461-01; NCGC00163461-02; NCGC00163461-03; DB-026237; FT-0618703; H2676; ST50201663; EN300-15634; BRD-K50212643-001-03-2; Q27185965; F3098-7925
Click to Show/Hide
|
||||
| Activity |
Ki = 160000 nM
|
[30] | |||
| Compound Name |
5-[2-(2-Methoxyphenyl)pent-1-enyl]furo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL595497
Click to Show/Hide
|
||||
| Activity |
IC50 = 160300 nM
|
[53] | |||
| Compound Name |
6-[(2,4-Dichlorophenyl)methyl]-4-N-(3-fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1095131; BDBM50318176; N4-(3-Fluorophenyl)-6-(2,4-dichlorobenzyl)-7H-pyrrolo-[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
||||
| Activity |
IC50 = 161600 nM
|
[67] | |||
| Compound Name |
alpha-Cyano-4-hydroxycinnamic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
alpha-Cyano; a-Cyano-4-hydroxycinnamic acid; 2-Cyano-3-(4-hydroxyphenyl)acrylic acid; (2E)-2-cyano-3-(4-hydroxyphenyl)prop-2-enoic acid; alpha-CHCA; alpha-cyano-4-hydroxy-cinnamic acid; (E)-2-cyano-3-(4-hydroxyphenyl)acrylic acid; MFCD00004204; 1-carboxy-1-cyano-2-(4-hydroxyphenyl)ethylene; Q63391607; 4-HCCA; alpha-CCA; 2-Propenoic acid, 2-cyano-3-(4-hydroxyphenyl)-; Spectrum5_001633; 2-Cyano-3-(4-hydroxyphenyl)-2-propenoic acid; SCHEMBL26825; BSPBio_002260; MLS002207285; CHEMBL76602; (E)-2-cyano-3-(4-hydroxyphenyl)prop-2-enoic acid; BDBM4350; HMS500K21; DTXSID501018295; ZINC155109; BBL103553; CCG-39475; GEO-00838; s8612; SBB057160; STL557363; .alpha.-Cyano-4-hydroxycinnamic acid; AKOS000145566; IDI1_000219; NCGC00094622-01; NCGC00094622-02; alpha-Cyano-4-hydroxybenzenepropenoic acid; alpha-Cyano-4-hydroxycinnamic acid, 97%; alpha-Cyano-4-hydroxycinnamic acid, 99%; benzylidenemalononitrile (BMN) deriv. 34; BS-16413; SMR001306800; 2-Cyano-3-(4-hydroxyphenyl)propenoic acid; HY-107641; CS-0029043; ST50997515; A819766; (E)-2-cyano-3-(4-hydroxyphenyl)-2-propenoic acid; BRD-K60302405-001-02-9; BRD-K60302405-001-04-5; (2E)-2-Cyano-3-(4-hydroxyphenyl)-2-propenoic acid #; alpha-Cyano-4-hydroxycinnamic acid, >=98% (TLC), powder; alpha-Cyano-4-hydroxycinnamic acid, purum, >=99.0% (HPLC); alpha-Cyano-4-hydroxycinnamic acid, suitable for MALDI-TOF MS; alpha-Cyano-4-hydroxycinnamic acid, matrix substance for MALDI-MS, Ultra pure
Click to Show/Hide
|
||||
| Activity |
IC50 = 165000 nM
|
[30] | |||
| Compound Name |
(E)-2-Cyano-3-[3-[(5-ethoxy-1,3-benzothiazol-2-yl)sulfanylmethyl]-4-hydroxy-5-methoxyphenyl]prop-2-enamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL343875; BDBM50409739
Click to Show/Hide
|
||||
| Activity |
IC50 = 165958.69 nM
|
[64] | |||
| Compound Name |
Tyrphostin deriv. 64
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL57251; BDBM4312; N-(2,4-Dimethoxyphenyl)-alpha-cyano-3,4-dihydroxycinnamamide; 2-Cyano-3-(3,4-dihydroxyphenyl)-N-(2,4-dimethoxyphenyl)acrylamide; (2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(2,4-dimethoxyphenyl)prop-2-enamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 166000 nM
|
[66] | |||
| Compound Name |
7-Benzyl-4-N-(3-bromophenyl)pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956888; BDBM50366088
Click to Show/Hide
|
||||
| Activity |
IC50 = 166400 nM
|
[25] | |||
| Compound Name |
(E)-2-Cyano-N-[3-[4-[3-[[(E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enoyl]amino]propyl]piperazin-1-yl]propyl]-3-(3,4-dihydroxyphenyl)prop-2-enamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL144402
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 167000 nM
|
[85] | |||
| Compound Name |
5-Naphthalen-1-ylsulfanyl-9H-pyrimido[4,5-b]indole-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4088617; BDBM50235697
Click to Show/Hide
|
||||
| Activity |
IC50 = 167300 nM
|
[129] | |||
| Compound Name |
13-(2,3-Dihydroxypropylamino)-5,21-dihydroxy-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL266182; BDBM50076935
Click to Show/Hide
|
||||
| Activity |
IC50 = 180000 nM
|
[73] | |||
| Compound Name |
N-[4-(3-Bromoanilino)-3-cyano-7-methoxyquinolin-6-yl]but-2-ynamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL116525; SCHEMBL6383794; BDBM50122572; N-[4-[(3-bromophenyl)amino]-3-cyano-7-methoxy -6-quinolinyl]-2-butynamide; N-[4-[(3-bromophenyl)amino]-3-cyano-7-methoxy-6-quinolinyl]-2-butynamide; But-2-ynoic acid [4-(3-bromo-phenylamino)-3-cyano-7-methoxy-quinolin-6-yl]-amide
Click to Show/Hide
|
||||
| Activity |
IC50 = 190020.3 nM
|
[93] | |||
| Compound Name |
3-(3,4-Dichlorophenyl)-5-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-phenyl-3,4-dihydropyrazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3805849; BDBM50172063
Click to Show/Hide
|
||||
| Activity |
IC50 = 192000 nM
|
[91] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 130 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Levodopa
Click to Show/Hide
|
Approved | Compound Info | ||
| Synonyms |
Levodopa (optimized formulation, Parkinson's disease); More effective levodopa (Parkinson's disease), Orion; Levodopa (optimized formulation, Parkinson's disease), Orion
Click to Show/Hide
|
||||
| Activity |
IC50 = 900000 nM
|
[30] | |||
| Compound Name |
3,4-Dihydroxycinnamic Acid
Click to Show/Hide
|
Phase 4 | Compound Info | ||
| Synonyms |
Caffeic acid; caffeic acid; 3,4-Dihydroxycinnamic acid; 331-39-5; 3-(3,4-dihydroxyphenyl)acrylic acid; 501-16-6; (E)-3-(3,4-dihydroxyphenyl)acrylic acid; 3,4-Dihydroxybenzeneacrylic acid; (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoic acid; trans-caffeic acid; trans-Caffeate; 3,4-Dihydroxy-trans-cinnamate; 2-Propenoic acid, 3-(3,4-dihydroxyphenyl)-; Cinnamic acid, 3,4-dihydroxy-; 3-(3,4-Dihydroxyphenyl)propenoic acid; UNII-U2S3A33KVM; 3-(3,4-Dihydroxyphenyl)-2-propenoic acid; 4-(2-Carboxyethenyl)-1,2-dihydroxybenzene
Click to Show/Hide
|
||||
| Activity |
Ki = 400000 nM
|
[30] | |||
| Compound Name |
Olomoucine
Click to Show/Hide
|
Terminated | Compound Info | ||
| Synonyms |
olomoucine; 101622-51-9; 4erk; UNII-6A839B2HYS; 2-(2-Hydroxyethylamino)-6-benzylamino-9-methylpurine; 6A839B2HYS; CHEMBL280074; 2-{[6-(benzylamino)-9-methyl-9h-purin-2-yl]amino}ethanol; 6-Benzylamino-2-(2-hydroxyethylamino)-9-methylpurine; 6-(Benzylamino)-2-(2-hydroxyethylamino)-9-methylpurine; Ethanol,2-[[9-methyl-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-; OLO; 2-(Hydroxyethylamino)-6-benzylamino-9-methylpurine; 6-Benylamino-2-(2-hydroxyethylamino)-9-methylpurine
Click to Show/Hide
|
||||
| Activity |
IC50 = 440000 nM
|
[46] | |||
| Compound Name |
5-[(2,5-Dihydroxyphenyl)methylideneamino]-2-hydroxy-N-methoxybenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL354300; BDBM50453567
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[33] | |||
| Compound Name |
N-[5-Chloro-4-(4-chloro-2-fluoroanilino)-9H-pyrimido[4,5-b]indol-2-yl]-2,2-dimethylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2337370; BDBM50430563
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[8] | |||
| Compound Name |
13-(1,3-Dihydroxypropan-2-ylamino)-5,21-dihydroxy-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL277008; BDBM50076922
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[73] | |||
| Compound Name |
4-N-(4-Chlorophenyl)-6-[(2-methylphenyl)methyl]-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1929553; BDBM50360175
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[49] | |||
| Compound Name |
N-(3-Bromo-4-fluorophenyl)-6-(2-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1096737; BDBM50318165; N-(3-bromo-4-flurophenyl)-6-(2-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[70] | |||
| Compound Name |
N-[4-(3-Ethynylanilino)-6-(2-pyridin-2-ylethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-2,2-dimethylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2335017; BDBM50429677
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[92] | |||
| Compound Name |
Edotecarin
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
J-107088; UNII-1V8X590XDP; PF-804950; 1V8X590XDP; CHEMBL435191; Edotecarina; E'dotecarine; Edotecarin [USAN:INN]; Edotecarinum [INN-Latin]; E'dotecarine [INN-French]; C29H28N4O11; Edotecarin (USAN/INN); J 107088; SCHEMBL5177060; ZINC3946372; BDBM50086570; CS-6688; DB04882; HY-13618; Z1880; D03954; Q27095555
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[130] | |||
| Compound Name |
4-N-(3-Bromophenyl)-7-[(4-phenylphenyl)methyl]pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956897; BDBM50366082
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[25] | |||
| Compound Name |
N-[5,21-Dihydroxy-12,14-dioxo-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaen-13-yl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL428453; BDBM50076930
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[73] | |||
| Compound Name |
N-(4-Chloro-2-fluorophenyl)-6-(2-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1096416; BDBM50318167
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[70] | |||
| Compound Name |
13-(Ethylamino)-5,21-dihydroxy-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL277011; BDBM50076942
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[73] | |||
| Compound Name |
4-N-(3-Bromophenyl)-7-[(3,4,5-trimethoxyphenyl)methyl]pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956898; BDBM50366081
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[25] | |||
| Compound Name |
3-[[5,21-Dihydroxy-12,14-dioxo-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaen-13-yl]amino]propanenitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL283766; BDBM50076938
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[73] | |||
| Compound Name |
N-(3-Ethynylphenyl)-6-(2-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1096972; BDBM50318163
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[70] | |||
| Compound Name |
5-Chloro-4-N-(3-fluorophenyl)-9H-pyrimido[4,5-b]indole-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2337365; BDBM50430568
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[8] | |||
| Compound Name |
13-(Dimethylamino)-5,21-dihydroxy-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL278071; BDBM50076939
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[73] | |||
| Compound Name |
N-[5,21-Dihydroxy-12,14-dioxo-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaen-13-yl]formamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL282436; BDBM50076943
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[73] | |||
| Compound Name |
6-(2-Phenylethyl)-N-[3-(trifluoromethyl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1097743; BDBM50318164
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[70] | |||
| Compound Name |
6,20-Dihydroxy-13-[[3-(hydroxymethyl)pyridin-4-yl]methylamino]-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL509544; BDBM50249696
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[130] | |||
| Compound Name |
N-(3-Bromophenyl)-6-(2-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1094423; BDBM50318162
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[70] | |||
| Compound Name |
5-[2-Cyclopropyl-2-(2-methoxyphenyl)ethenyl]furo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL594320
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[53] | |||
| Compound Name |
5-Chloro-4-N-phenyl-9H-pyrimido[4,5-b]indole-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2337374; BDBM50430572
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[8] | |||
| Compound Name |
[5,21-Dihydroxy-12,14-dioxo-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaen-13-yl]urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL277039; BDBM50076921
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[73] | |||
| Compound Name |
N-[5,21-Dihydroxy-12,14-dioxo-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaen-13-yl]propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL278101; BDBM50076931
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[73] | |||
| Compound Name |
6,20-Dihydroxy-13-[[6-(hydroxymethyl)pyridin-2-yl]methylamino]-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL474561; BDBM50249689
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[130] | |||
| Compound Name |
4-N-(3-Bromophenyl)-7-[(2,4-dichlorophenyl)methyl]pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956893; BDBM50366086
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[25] | |||
| Compound Name |
N-[5,21-Dihydroxy-12,14-dioxo-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaen-13-yl]pyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL20255; BDBM50076925
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[73] | |||
| Compound Name |
N4-(3-Ethynylphenyl)-6-phenethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL520803; BDBM50271849; N4-(3-Ethynylphenyl)-6-(2-phenylethyl)-7H-pyrrolo[2,3-d ]pyrimidine-2,4-diamine
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[70] | |||
| Compound Name |
5-[2-(2-Methoxyphenyl)-3-methylpent-1-enyl]furo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL603849
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[53] | |||
| Compound Name |
N-[5,21-Dihydroxy-12,14-dioxo-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaen-13-yl]methanesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL277408; BDBM50076924
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[73] | |||
| Compound Name |
6,20-Dihydroxy-13-(pyridin-4-ylmethylamino)-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL455328; BDBM50249674
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[130] | |||
| Compound Name |
2-[[5,21-Dihydroxy-12,14-dioxo-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaen-13-yl]amino]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL21263; BDBM50076932
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[73] | |||
| Compound Name |
2,4-Diaminofuro[2,3-d]pyrimidine, 13
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL594339; BDBM33407
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[53] | |||
| Compound Name |
5,21-Dihydroxy-13-[(3-hydroxyphenyl)methylamino]-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL282655; BDBM50076933
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[73] | |||
| Compound Name |
5,21-Dihydroxy-13-(2-hydroxyethylamino)-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL20811; BDBM50076920
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[73] | |||
| Compound Name |
N4-1H-Indol-5-yl-6-(2-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL499067; BDBM50271905; N4-(1H-indol-5-yl)-6-phenethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[70] | |||
| Compound Name |
N-[5,21-Dihydroxy-12,14-dioxo-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaen-13-yl]-2-(dimethylamino)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL278757; BDBM50076934
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[73] | |||
| Compound Name |
6-Phenethyl-N4-(3-(trifluoromethyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL483312; BDBM50271848; N4-(3-Trifluromethylphenyl)-6-(2-phenylethyl)-7Hpyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[70] | |||
| Compound Name |
5-[(1z)-2-(2-Methoxyphenyl)prop-1-En-1-Yl]furo[2,3-D]pyrimidine-2,4-Diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL606039; BDBM33395; 2,4-diaminofuro[2,3-d]pyrimidine, 1b; Q27455399
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[53] | |||
| Compound Name |
4-N-(4-Chlorophenyl)-6-[(2,5-dimethoxyphenyl)methyl]-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1929557; BDBM50360179
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[49] | |||
| Compound Name |
2-Amino-4-(m-bromoanilino)-6-(2,5-dimethoxybenzyl)-7-methyl-pyrrolo[2,3-d]pyrimidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1254522; BDBM50326616
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[62] | |||
| Compound Name |
4-N-(3-Bromophenyl)-7-[(3,4-dichlorophenyl)methyl]pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956894; BDBM50366085
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[25] | |||
| Compound Name |
4-N-(3-Bromophenyl)-7-(naphthalen-1-ylmethyl)pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956895; BDBM50366084
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[25] | |||
| Compound Name |
13-Amino-5,21-dihydroxy-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL21265; BDBM50076923
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[73] | |||
| Compound Name |
N-[4-Fluoro-3-(trifluoromethyl)phenyl]-6-(2-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1096415; BDBM50318166
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[70] | |||
| Compound Name |
N-[5,21-Dihydroxy-12,14-dioxo-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaen-13-yl]-4-methylbenzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL21267; BDBM50076941
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[73] | |||
| Compound Name |
5-[2-(2-Methoxyphenyl)-4-methylpent-1-enyl]furo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL593154
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[53] | |||
| Compound Name |
2-Amino-4-(m-bromoanilino)-6-benzyl-7-methyl-pyrrolo-[2,3-d]pyrimidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1254285; BDBM50326610
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[62] | |||
| Compound Name |
2-Cyano-N-[5,21-dihydroxy-12,14-dioxo-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaen-13-yl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL278526; BDBM50076929
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[73] | |||
| Compound Name |
4-N-(3-Bromophenyl)-7-(naphthalen-2-ylmethyl)pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956896; BDBM50366083
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[25] | |||
| Compound Name |
N-[5,21-Dihydroxy-12,14-dioxo-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaen-13-yl]-2-hydroxyacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL21221; BDBM50076927
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[73] | |||
| Compound Name |
N-[5,21-Dihydroxy-12,14-dioxo-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaen-13-yl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL277432; BDBM50076926
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[73] | |||
| Compound Name |
N4-(3-Bromo-4-fluorophenyl)-6-phenethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL483108; BDBM50271803; N4-(3-bromo-4-fluorophenyl)-6-(2-phenylethyl)-7Hpyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[131] | |||
| Compound Name |
4-N-(3-Bromophenyl)-7-[(2-chlorophenyl)methyl]pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956890; BDBM50366087
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[25] | |||
| Compound Name |
Propanedinitrile, [(4-hydroxyphenyl)hydrazono]-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Propanedinitrile, 2-[2-(4-hydroxyphenyl)hydrazinylidene]-; CHEMBL310958; CTK1F5591; DTXSID70416174; [2-(4-Hydroxyphenyl)hydrazono]malononitrile
Click to Show/Hide
|
||||
| Activity |
IC50 = 225000 nM
|
[30] | |||
| Compound Name |
Malononitrile, (3-pyridylmethylene)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-(pyridin-3-ylmethylidene)propanedinitrile; 3-Pyridylmethylenemalononitrile; (pyridin-3-ylmethylidene)propanedinitrile; 2-[(pyridin-3-yl)methylidene]propanedinitrile; 2-((PYRIDIN-3-YL)METHYLIDENE)PROPANEDINITRILE; NSC 102579; BRN 0118555; Propanedinitrile, (3-pyridinylmethylene)-; NSC102579; Tyrphostin deriv. 1; NCIOpen2_001710; 4-22-00-01672 (Beilstein Handbook Reference); MLS000420228; CHEMBL56281; WLN: T6NJ C1UYCN&CN; BDBM4271; SCHEMBL22208284; CTK5D9601; DTXSID30225229; HMS2671G09; ZINC104275; (3-Pyridinylmethylene)malononitrile; BBL005585; MFCD00466404; STK170257; AKOS002951300; 2-(pyridin-3-ylmethylene)malononitrile; MCULE-5955098708; NSC-102579; 2-(pyridin-3-yl-methylene)malononitrile; NCGC00246596-01; SMR000322817; ST50685036; T8150; KS-00003552; (3-pyridylmethylene)methane-1,1-dicarbonitrile; 2Z-0210; Propanedinitrile, (3-pyridinylmethylene)- (9CI); F0192-0845
Click to Show/Hide
|
||||
| Activity |
IC50 = 225000 nM
|
[66] | |||
| Compound Name |
2-(Hydroxy(4-Hydroxyphenyl)Methylene)Malononitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL79064; SCHEMBL8743684; 2-[hydroxy-(4-hydroxyphenyl)methylidene]propanedinitrile; alpha,4-Dihydroxybenzylidenemalononitrile; Propanedinitrile, 2-[hydroxy(4-hydroxyphenyl)methylene]-
Click to Show/Hide
|
||||
| Activity |
IC50 = 230000 nM
|
[30] | |||
| Compound Name |
US9422297, Aag145-344
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3985894; SCHEMBL12391860; BDBM242736
Click to Show/Hide
|
||||
| Activity |
IC50 = 232700 nM
|
[95] | |||
| Compound Name |
Benzylidenemalononitrile (BMN) deriv. 5
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM4321; CHEMBL307248; 3-{[4-(2,2-dicyanoeth-1-en-1-yl)phenyl]carbamoyl}propanoic acid
Click to Show/Hide
|
||||
| Activity |
Ki = 240000 nM
|
[30] | |||
| Compound Name |
2-[(3-Hydroxy-4-methoxyphenyl)methylidene]propanedinitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Propanedinitrile, [(3-hydroxy-4-methoxyphenyl)methylene]-; ACMC-20lo8i; CBMicro_011382; (3-hydroxy-4-methoxybenzylidene)propanedinitrile; Oprea1_808014; CHEMBL78302; BDBM4331; CTK2J3261; ZINC68542; DTXSID50351256; SMSF0003896; MCK103044; STK327993; AKOS001309150; CB14854; MCULE-1273790076; benzylidenemalononitrile (BMN) deriv. 15; BIM-0011453.P001; (3-Hydroxy-4-methoxybenzylidene)malononitrile; 1-cyano-2-(3-hydroxy-4-methoxyphenyl)vinyl cyanide; Propanedinitrile, 2-[(3-hydroxy-4-methoxyphenyl)methylene]-
Click to Show/Hide
|
||||
| Activity |
IC50 > 250000 nM
|
[30] | |||
| Compound Name |
5-(2,2-Dicyanoethenyl)furan-2-sulfonic acid sodium salt
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL56674
Click to Show/Hide
|
||||
| Activity |
IC50 > 250000 nM
|
[66] | |||
| Compound Name |
2-(2-Oxoindolin-3-ylidene)malononitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
(2-oxo-1,2-dihydro-3h-indol-3-ylidene)malononitrile; (2-oxo-1,2-dihydro-3H-indol-3-ylidene)propanedinitrile; 2-(2-oxo-1H-indol-3-ylidene)propanedinitrile; CHEMBL293798; 2-(2-oxo-2,3-dihydro-1H-indol-3-ylidene)propanedinitrile; Propanedinitrile, 2-(1,2-dihydro-2-oxo-3H-indol-3-ylidene)-; NSC55483; Tyrphostin deriv. 22; Oprea1_813847; Oprea1_814560; BDBM4291; 3-(dicyanomethylene)-2-indolone; CTK7C4152; ZINC47961; DTXSID30984743; 3-(Dicyanomethylene)indoline-2-one; NSC61793; (2-Oxo-3-indolinidene)malononitrile; BBL022696; MFCD00175750; NSC-55483; NSC-61793; NSC229043; RSC002726; STK057179; AKOS000359216; MCULE-4580177467; NSC-229043; ST097194; T8422; EN300-31032; Z57493510; F1006-0007; 2-(2-Oxo-1,2-dihydro-3H-indol-3-ylidene)malononitrile #; (2-oxo-1H-benzo[d]azolidin-3-ylidene)methane-1,1-dicarbonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 > 250000 nM
|
[66] | |||
| Compound Name |
Malononitrile, (4-pyridylmethylene)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
1,1-dicyano-2-(pyridine-4-yl)ethylene; 2-(pyridin-4-ylmethylidene)propanedinitrile; BRN 3538924; 4-(Pyridylmethylene)malononitrile; CHEMBL77737; 4-Pyridylmethylenemalononitrile; 4-(2,2-dicyanovinyl)pyridine; BDBM4372; SCHEMBL7708384; DTXSID10212410; 4-pyridinylmethylen-propanedinitril; ZINC12938134; AKOS002951299; MCULE-2461934472; benzylidenemalononitrile (BMN) deriv. 56; ST50996829; (4-pyridylmethylene)methane-1,1-dicarbonitrile; A1-00315
Click to Show/Hide
|
||||
| Activity |
IC50 = 250000 nM
|
[30] | |||
| Compound Name |
(4-Morpholin-4-ylbenzylidene)malononitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-{[4-(morpholin-4-yl)phenyl]methylidene}propanedinitrile; NSC275408; 2-[(4-morpholin-4-ylphenyl)methylidene]propanedinitrile; Oprea1_072840; Oprea1_271919; MLS000712607; BDBM4322; CHEMBL420385; cid_321779; SCHEMBL1009547; DTXSID60313709; HMS2750E10; ZINC342449; ALBB-022589; MCK100287; MFCD00654980; (4-Morpholinobenzylidene)malononitrile; AKOS000438151; MCULE-2826358307; NSC-275408; 2-(4-Morpholinobenzylidene)malononitrile; benzylidenemalononitrile (BMN) deriv. 6; SMR000282374; R3593; 2-[4-(4-morpholinyl)benzylidene]malononitrile; AG-690/08774024; SR-01000313850; SR-01000313850-1; Propanedinitrile, [[4-(4-morpholinyl)phenyl]methylene]-
Click to Show/Hide
|
||||
| Activity |
Ki > 250000 nM
|
[30] | |||
| Compound Name |
N-[4-(3-Bromoanilino)-3-cyanoquinolin-6-yl]-4-(propan-2-ylamino)but-2-ynamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2262408; BDBM50487309
Click to Show/Hide
|
||||
| Activity |
IC50 = 250034.54 nM
|
[93] | |||
| Compound Name |
2-Amino-4-(N-methyl-m-bromoanilino)-6-benzyl-7-methyl-pyrrolo[2,3-d]pyrimidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1254286; BDBM50326611
Click to Show/Hide
|
||||
| Activity |
IC50 = 253600 nM
|
[62] | |||
| Compound Name |
2-(1H-Pyrrol-2-ylmethylene)malononitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-(1H-pyrrol-2-ylmethylidene)propanedinitrile; 2-(1H-pyrrol-2-ylmethylidene)malononitrile; 2-[(1H-pyrrol-2-yl)methylidene]propanedinitrile; 2-(2,2-dicyanovinyl)pyrrole; BDBM4371; CHEMBL310514; SCHEMBL3462848; CTK7C4477; KS-00001XDE; DTXSID80383641; ZINC164240; MFCD00173105; AKOS005092211; MCULE-4136401248; benzylidenemalononitrile (BMN) deriv. 55; 2-(1H-Pyrrole-2-ylmethylene)malononitrile; DB-004481; FT-0702405; 5F-037
Click to Show/Hide
|
||||
| Activity |
IC50 = 260000 nM
|
[30] | |||
| Compound Name |
(3R,4S)-3-Fluoro-1-[4-[[2-[(1R)-1-hydroxyethyl]-1-[(2R)-1,1,1-trifluoropropan-2-yl]imidazo[4,5-c]pyridin-6-yl]amino]pyrimidin-2-yl]piperidin-4-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3734988; SCHEMBL15749380; BDBM50498974
Click to Show/Hide
|
||||
| Activity |
IC50 = 261000 nM
|
[132] | |||
| Compound Name |
(E)-2-Cyano-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
benzylidenemalononitrile (BMN) deriv. 33; CHEMBL76979; BDBM4349; SCHEMBL8749247; 4-Hydroxy-3,5-dimethoxy-alpha-cyanocinnamic acid; (2E)-2-cyano-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 264000 nM
|
[30] | |||
| Compound Name |
4-Phenyl-[1]benzofuro[2,3-b]pyridine-3,6-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2163772; BDBM50395892
Click to Show/Hide
|
||||
| Activity |
Ki = 296000 nM
|
[133] | |||
| Compound Name |
US9422297, Aag145-341
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3977751; BDBM242734
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[95] | |||
| Compound Name |
N-(3-Bromophenyl)-6-(2,4-dichlorobenzyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1094783; BDBM50318186
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[67] | |||
| Compound Name |
US9422297, Aag145-347
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3983639; BDBM242738
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[95] | |||
| Compound Name |
2-(4-Hydroxyphenyl)benzothiazole-4,6-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL45564; BDBM50407167
Click to Show/Hide
|
||||
| Activity |
IC50 = 300000 nM
|
[9] | |||
| Compound Name |
2-[(4-Hydroxy-3,5-dimethoxyphenyl)methylidene]propanedinitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
(4-hydroxy-3,5-dimethoxybenzylidene)propanedinitrile; Oprea1_498351; Oprea1_735588; BDBM4320; CHEMBL421877; SCHEMBL8745026; ZINC190060; BBL005812; MCK100650; MFCD00810338; STL134550; AKOS001112521; MCULE-1865360454; UPCMLD0ENAT5389863:001; benzylidenemalononitrile (BMN) deriv. 4; T8887; 2-(4-Hydroxy-3,5-dimethoxybenzylidene)malononitrile; Z44300075; 2-(4-Hydroxy-3,5-dimethoxybenzylidene)propanedinitrile; F6782-3626
Click to Show/Hide
|
||||
| Activity |
Ki = 300000 nM
|
[30] | |||
| Compound Name |
6-(2,4-Dichlorobenzyl)-N-(3-ethynylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1098440; BDBM50318188
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[67] | |||
| Compound Name |
N-(3-Bromophenyl)-6-(2-methylbenzyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1095466; BDBM50318184
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[67] | |||
| Compound Name |
5-(2,3-Dihydro-1,4-benzodioxin-6-yl)-3-(3-methoxyphenyl)-2-phenyl-3,4-dihydropyrazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3805675; BDBM50172058
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[91] | |||
| Compound Name |
US9422297, Aag145-340
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3976755; BDBM242733
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[95] | |||
| Compound Name |
N4-(4-Bromo-2-chlorophenyl)-6-(2,4-dichlorobenzyl)-7Hpyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1095762; BDBM50318173; 7H-Pyrrolo[2,3-d]pyrimidine-2,4-diamine, N4-(4-bromo-2-chlorophenyl)-6-[(2,4-dichlorophenyl)methyl]-
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[67] | |||
| Compound Name |
4-[5-(2,3-Dihydro-1,4-benzodioxin-6-yl)-2-phenyl-3,4-dihydropyrazol-3-yl]-N,N-dimethylaniline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3806108; BDBM50172062
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[91] | |||
| Compound Name |
US9422297, Aag145-346
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3953855; BDBM242737
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[95] | |||
| Compound Name |
N-(3-Bromophenyl)-6-(2,5-dimethoxybenzyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1094782; BDBM50318185
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[67] | |||
| Compound Name |
4-Dimethylamino-but-2-enoic acid [4-(3-bromo-phenylamino)-3-cyano-quinolin-6-yl]-amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL30973; SCHEMBL8155341; BDBM50122567; (E)-4-Dimethylamino-but-2-enoic acid [4-(3-bromo-phenylamino)-3-cyano-quinolin-6-yl]-amide
Click to Show/Hide
|
||||
| Activity |
IC50 = 310027.34 nM
|
[93] | |||
| Compound Name |
2-[(3,5-Ditert-butyl-4-hydroxyphenyl)methylidene]cyclopent-4-ene-1,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
TX-1123; CHEMBL258726; 2-((3,5-di-tert-Butyl-4-hydroxyphenyl)-methylene)-4-cyclopentene-1,3-dione; NSC718729; SCHEMBL16971041; CTK6A4583; BDBM50375666; AKOS025294616; NSC-718729; NCI60_040912; J-009415; 2-(3,5-di-tert-butyl-4-hydroxybenzylidene)cyclopent-4-ene-1,3-dione; [2-((3,5-di-tert-Butyl-4-hydroxyphenyl)-methylene)-4-cyclopentene-1,3-dione]; Cyclopent-4-ene-1, 2-[[4-hydroxy-3,5-bis(1,1-dimethylethyl)phenyl]methyl]-
Click to Show/Hide
|
||||
| Activity |
IC50 = 320000 nM
|
[17] | |||
| Compound Name |
N-(4-(2,2-Dicyanovinyl)phenyl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-(4-Acetamidobenzylidene)malononitrile; N-[4-(2,2-dicyanoethenyl)phenyl]acetamide; 4'-(2,2-Dicyanovinyl)acetanilide; N-[4-(2,2-dicyanovinyl)phenyl]acetamide; ACETANILIDE, 4'-(2,2-DICYANOVINYL)-; N-[4-(2,2-dicyanoeth-1-en-1-yl)phenyl]acetamide; NSC 56077; BRN 2372655; Acetamide, N-[4-(2,2-dicyanoethenyl)phenyl]-; NSC56077; Tyrphostin deriv. 3; Oprea1_608033; Acetanilide,2-dicyanovinyl)-; 4-14-00-01928 (Beilstein Handbook Reference); CHEMBL57631; SCHEMBL412241; BDBM4273; CTK4F7042; DTXSID60180716; HMS1580E01; ZINC283219; Acetamide,2-dicyanoethenyl)phenyl]-; 2228AB; 4'-(2,2-Dicyanoethenyl)acetanilide; MCK100648; NSC-56077; STK834811; AKOS005623834; MCULE-6585425132; AC-22517; DB-046830; FT-0638571; ST50547634; N-[4-(2,2-Dicyano-vinyl)-phenyl]-acetamide; Acetamide,N-[4-(2,2-dicyanoethenyl)phenyl]-; ALPHA-DICYANOMETHYLENE-PARA-ACETOTOLUIDIDE; 088A799; SR-01000202866; SR-01000202866-1; Acetamide, N-(4-(2,2-dicyanoethenyl)phenyl)- (9CI)
Click to Show/Hide
|
||||
| Activity |
IC50 > 325000 nM
|
[66] | |||
| Compound Name |
(2E)-2-Cyano-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
benzylidenemalononitrile (BMN) deriv. 32; 2-cyano-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid; (E)-2-cyano-3-(4-hydroxy-3-methoxyphenyl)-2-propenoic acid; BDBM4348; CHEMBL307250; ZINC122665; AKOS000146851; 4-Hydroxy-3-methoxy-alpha-cyanocinnamic acid; 9X-0858; SR-01000309519; SR-01000309519-1
Click to Show/Hide
|
||||
| Activity |
IC50 = 325000 nM
|
[30] | |||
| Compound Name |
4-Methoxymethoxy-but-2-ynoic acid[4-(3-bromophenylamino)-3-cyano-quinolin-6-yl]-amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL441279; SCHEMBL1895351; BDBM50148234; 4-methoxymethoxy-but-2-ynoic acid[4-(3-bromo-phenylamino)-3-cyano-quinolin-6-yl]-amide
Click to Show/Hide
|
||||
| Activity |
IC50 = 330065.4 nM
|
[93] | |||
| Compound Name |
Benzylidenemalononitrile (BMN) deriv. 38
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL77197; BDBM4354; (2E)-2-cyano-3-(4-hydroxy-3-methoxyphenyl)but-2-enoic acid
Click to Show/Hide
|
||||
| Activity |
Ki = 341000 nM
|
[30] | |||
| Compound Name |
Propanedinitrile, 2-[[(4-hydroxyphenyl)amino]methylene]-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL77814; AKOS003490839
Click to Show/Hide
|
||||
| Activity |
IC50 = 350000 nM
|
[30] | |||
| Compound Name |
N-[2-[(3R)-3-(Dimethylamino)pyrrolizino]-4-methoxy-5-[4-(pyrazolo[1,5-a]pyridine-3-yl)-5-chloropyrimidine-2-ylamino]phenyl]acrylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3353403; SCHEMBL14719220; BDBM50029684
Click to Show/Hide
|
||||
| Activity |
IC50 = 357000 nM
|
[71] | |||
| Compound Name |
Benzylidenemalononitrile (BMN) deriv. 40
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL76557; BDBM4356; (2E)-2-cyano-N-(cyanomethyl)-3-(4-hydroxyphenyl)prop-2-enamide
Click to Show/Hide
|
||||
| Activity |
Ki = 360000 nM
|
[30] | |||
| Compound Name |
2-(4-Hydroxy-3-methoxy-5-phenylsulfanylmethyl-benzylidene)-malononitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL122522; BDBM50036689; 2-[3-[(Phenylthio)methyl]-4-hydroxy-5-methoxybenzylidene]propanedinitrile
Click to Show/Hide
|
||||
| Activity |
IC50 = 370000 nM
|
[36] | |||
| Compound Name |
2-[(4-Fluorophenyl)methylidene]propanedinitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-(4-Fluorobenzylidene)malononitrile; NSC637327; 4-Fluorobenzalmalononitrile; 2-(4-Fluorobenzylidene)-malononitrile; (4-fluorobenzylidene)malononitrile; (4-fluorobenzylidene)propanedinitrile; Propanedinitrile, [(4-fluorophenyl)methylene]-; [(4-fluorophenyl)methylene]methane-1,1-dicarbonitrile; CHEMBL76983; BDBM4319; SCHEMBL3368837; CTK0J2139; ZINC99963; DTXSID80327222; beta,beta-Dicyano-4-fluorostyrene; BBL005362; MCK100002; MFCD00466403; RSC003287; SBB088614; STK183333; AKOS001063390; AS-8878; MCULE-1385536004; NSC-637327; 2-(4-Fluorobenzylidene)malononitrile #; 2-(4-Fluorobenzylidene)propanedinitrile; 1-(4-fluorophenyl)-2,2-dicyanoethylene; benzylidenemalononitrile (BMN) deriv. 3; [(4-Fluorophenyl)methylidene]propanedinitrile; FT-0690439; ST50684355; T7624; 2-[(4-fluorophenyl)methylene]propanedinitrile; Benzene, 1-fluoro-4-(2,2-dicyanoethenyl)-; Propanedinitrile, 2-[(4-fluorophenyl)methylene]-; Z44300017; F3147-4397
Click to Show/Hide
|
||||
| Activity |
Ki > 400000 nM
|
[30] | |||
| Compound Name |
2-(3-Hydroxyphenyl)ethene-1,1,2-tricarbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL449114; BDBM50292528
Click to Show/Hide
|
||||
| Activity |
IC50 = 400000 nM
|
[29] | |||
| Compound Name |
(3,5-Dimethoxybenzylidene)propanedinitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-[(3,5-dimethoxyphenyl)methylidene]propanedinitrile; Propanedinitrile,2-[(3,5-dimethoxyphenyl)methylene]-; [(3,5-dimethoxyphenyl)methylene]methane-1,1-dicarbonitrile; Tyrphostin AG-81; NSC136545; Oprea1_324487; CHEMBL77724; BDBM4318; Propanedinitrile, 2-[(3,5-dimethoxyphenyl)methylene]-; CTK4F8007; DTXSID10300386; ZINC102422; MCK102975; RSC006643; AKOS003683422; MCULE-2229804536; NSC-136545; benzylidenemalononitrile (BMN) deriv. 2; ST014281; 2-(3,5-Dimethoxybenzylidene)malononitrile
Click to Show/Hide
|
||||
| Activity |
Ki > 400000 nM
|
[30] | |||
| Compound Name |
2-((3,5-Dimethyl-4-hydroxyphenyl)-methylene)-4-cyclopentene-1,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
TX-1918; CHEMBL437612; 2-[(4-hydroxy-3,5-dimethylphenyl)methylidene]cyclopent-4-ene-1,3-dione; K00011; SCHEMBL16971039; CTK8G3670; HMS3229P13; HMS3674M15; BCP16358; BDBM50375667; ZINC35212842; TX 1918;TX1918; 2-[(4-Hydroxy-3,5-dimethylphenyl)methylene]-4-cyclopentene-1,3-dione; TX-1918; 2-((3,5-dimethyl-4-hydroxyphenyl)-methylene)-4-cyclopentene-1,3-dione
Click to Show/Hide
|
||||
| Activity |
IC50 = 440000 nM
|
[17] | |||
| Compound Name |
N-(3-Chlorophenyl)-5,6,7-trimethylpyrrolo[2,3-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL120667
Click to Show/Hide
|
||||
| Activity |
IC50 = 450000 nM
|
[112] | |||
| Compound Name |
Propanedinitrile, 2-[hydroxy(4-methoxyphenyl)methylene]-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL311564
Click to Show/Hide
|
||||
| Activity |
IC50 = 450000 nM
|
[30] | |||
| Compound Name |
Benzylidenemalononitrile (BMN) deriv. 41
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM4357; CHEMBL306988; 3-{[4-(1,1-dicyanoprop-1-en-2-yl)phenyl]carbamoyl}propanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 500000 nM
|
[30] | |||
| Compound Name |
2,4-Diaminofuro[2,3-d]pyrimidine, 12
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL606362; BDBM33406
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[53] | |||
| Compound Name |
(E)-3-[3-Tert-butyl-4-hydroxy-5-[(2-methylpropan-2-yl)oxy]phenyl]-2-cyanoprop-2-enethioamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL140213; BDBM50409736
Click to Show/Hide
|
||||
| Activity |
IC50 = 501187.23 nM
|
[64] | |||
| Compound Name |
5-[2-(2-Methoxyphenyl)hex-1-enyl]furo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL604879
Click to Show/Hide
|
||||
| Activity |
IC50 = 529300 nM
|
[53] | |||
| Compound Name |
2-(1H-Imidazol-2-ylmethylidene)propanedinitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Propanedinitrile, (1H-imidazol-2-ylmethylene)-; Tyrphostin deriv. 4; BDBM4274; CHEMBL293482; CTK2I6677; DTXSID60416168; AKOS006352454; [(1H-Imidazol-2-yl)methylene]malononitrile
Click to Show/Hide
|
||||
| Activity |
IC50 = 532000 nM
|
[66] | |||
| Compound Name |
N-[4-(3-Bromoanilino)-3-cyanoquinolin-6-yl]-4-thiomorpholin-4-ylbut-2-ynamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL327023; BDBM50122577; 4-Thiomorpholin-4-yl-but-2-ynoic acid [4-(3-bromo-phenylamino)-3-cyano-quinolin-6-yl]-amide
Click to Show/Hide
|
||||
| Activity |
IC50 = 550047.25 nM
|
[93] | |||
| Compound Name |
2-[(6-Nitro-1,3-benzodioxol-5-yl)methylidene]propanedinitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
ST036284; 3,.4-Methylenedioxy-6-nitrobenzylidene malononitrile; 2-[(6-nitro-2H-1,3-benzodioxol-5-yl)methylidene]propanedinitrile; Oprea1_092159; Oprea1_435119; CHEMBL76082; ARONIS017977; BDBM4323; SCHEMBL6278899; ZINC95623; KS-00004A9N; MCK100670; STK068866; AKOS000485531; MCULE-6088679964; benzylidenemalononitrile (BMN) deriv. 7; 3,4-Methylenedioxy-6-nitrobenzylidene malononitrile; [(6-nitro-1,3-benzodioxol-5-yl)methylene]malononitrile; [3,4-(Methylenedioxy)-6-nitrobenzylidene]malononitrile; 2-[(6-Nitro-1,3-benzodioxole-5-yl)methylene]malononitrile; [(6-nitro-1,3-benzodioxol-5-yl)methylidene]propanedinitrile; 2-[(6-Nitro-1,3-benzodioxol-5-yl)methylidene]malononitrile
Click to Show/Hide
|
||||
| Activity |
IC50 = 560000 nM
|
[30] | |||
| Compound Name |
N-[4-(3-Chloro-4-fluoro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-2-dimethylaminomethyl-acrylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL117326; BDBM50122579
Click to Show/Hide
|
||||
| Activity |
IC50 = 560015.44 nM
|
[93] | |||
| Compound Name |
N-[4-(3-Bromo-phenylamino)-3-cyano-quinolin-6-yl]-acrylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL281300; SCHEMBL6382090; BDBM50122562; N-[4-(3-bromoanilino)-3-cyanoquinolin-6-yl]prop-2-enamide; N-[4-[(3-Bromophenyl)amino]-3-cyano-6-quinolinyl]-2-propenamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 590065.2 nM
|
[93] | |||
| Compound Name |
Propanedinitrile, ((4-methoxyphenyl)hydrazono)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-[(4-methoxyphenyl)hydrazono]malononitrile; BRN 1842409; Mesoxalonitrile, (p-methoxyphenyl)hydrazone; ((4-Methoxyphenyl)hydrazono)propanedinitrile; 4-15-00-01330 (Beilstein Handbook Reference); CHEMBL77825; 2-[(4-methoxyphenyl)hydrazinylidene]propanedinitrile; ARONIS020086; RSCBB000088; DTXSID70153057; Propanedinitrile, 2-[2-(4-methoxyphenyl)hydrazinylidene]-; ZINC357630; KS-00004BW1; STK054058; AKOS000486691; MCULE-3163440158; [(4-methoxyphenyl)hydrazono]malononitrile; [2-(4-Methoxyphenyl)hydrazono]malononitrile; 2-[(4-methoxyphenyl)hydrazono] malononitrile; AN-329/33310020; [2-(4-methoxyphenyl)hydrazinylidene]propanedinitrile; 1-CYANO-N-(4-METHOXYPHENYL)METHANECARBOHYDRAZONOYL CYANIDE
Click to Show/Hide
|
||||
| Activity |
IC50 = 600000 nM
|
[30] | |||
| Compound Name |
2-(4-Formylphenyl)ethene-1,1,2-tricarbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL489349; BDBM50292530
Click to Show/Hide
|
||||
| Activity |
IC50 = 600000 nM
|
[29] | |||
| Compound Name |
2-(4-Hydroxyphenyl)ethene-1,1,2-tricarbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL450319; SCHEMBL15494488; BDBM50292531
Click to Show/Hide
|
||||
| Activity |
IC50 = 600000 nM
|
[29] | |||
| Compound Name |
2-{[4-(Methylsulfanyl)phenyl]methylidene}propanedinitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-{[4-(methylsulfanyl)phenyl]methylene}malononitrile; [(4-methylthiophenyl)methylene]methane-1,1-dicarbonitrile; ((4-METHYLTHIOPHENYL)METHYLENE)METHANE-1,1-DICARBONITRILE; Tyrphostin deriv. 5; Maybridge1_007317; CHEMBL57471; BDBM4275; 2-[(4-methylsulfanylphenyl)methylidene]propanedinitrile; Propanedinitrile, 2-[[4-(methylthio)phenyl]methylene]-; HMS562E13; ZINC100467; KS-000028UA; MCK102230; MFCD00176176; SBB062365; (4-Methylthiobenzylidene)malononitrile; AKOS000369883; MCULE-5548087072; MS-6872
Click to Show/Hide
|
||||
| Activity |
IC50 > 625000 nM
|
[66] | |||
| Compound Name |
(E)-4-Dimethylamino-but-2-enoic acid [4-(3-chloro-4-fluoro-phenylamino)-3-cyano-quinolin-6-yl]-amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL323630; SCHEMBL6382554; SCHEMBL6384324; BDBM50122563; 4-Dimethylamino-but-2-enoic acid [4-(3-chloro-4-fluoro-phenylamino)-3-cyano-quinolin-6-yl]-amide
Click to Show/Hide
|
||||
| Activity |
IC50 = 650129.69 nM
|
[93] | |||
| Compound Name |
N-[4-Methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]-2-[methyl-[2-(methylamino)ethyl]amino]phenyl]prop-2-enamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
AZ7550; UNII-NI2ZUZ6F4O; NI2ZUZ6F4O; CHEMBL3353412; AZ-7550; Osimertinib metabolite M3; SCHEMBL14661086; BCP20939; HY-B0794; BDBM50029687; CS-8145
Click to Show/Hide
|
||||
| Activity |
IC50 = 786000 nM
|
[71] | |||
| Compound Name |
4-Dimethylamino-but-2-enoic acid [4-(3-bromo-phenylamino)-3-cyano-7-methoxy-quinolin-6-yl]-amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL263788; BDBM50122560; (E)-4-Dimethylamino-but-2-enoic acid [4-(3-bromo-phenylamino)-3-cyano-7-methoxy-quinolin-6-yl]-amide
Click to Show/Hide
|
||||
| Activity |
IC50 = 790132.64 nM
|
[93] | |||
| Compound Name |
N-[4-(3-Bromoanilino)-3-cyano-7-methoxyquinolin-6-yl]-4-methoxybut-2-ynamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL326280; BDBM50122588; 4-Methoxy-but-2-ynoic acid [4-(3-bromo-phenylamino)-3-cyano-7-methoxy-quinolin-6-yl]-amide
Click to Show/Hide
|
||||
| Activity |
IC50 = 790678.63 nM
|
[93] | |||
| Compound Name |
(2E)-2-Cyano-3-(4-hydroxyphenyl)prop-2-enamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL308048; NSC117971; BDBM4355; SCHEMBL9539318; alpha-Cyano-4-hydroxycinnamamide; ZINC160670; CCG-50900; NSC638074; alpha-Cyano-4-hydroxybenzeneacrylamide; AKOS016024289; NSC-117971; NSC-638074; benzylidenemalononitrile (BMN) deriv. 39; 2-Propenamide, 2-cyano-3-(4-hydroxyphenyl)-; (2E)-2-cyano-3-(4-hydroxyphenyl)-2-propenamide; SR-01000640240-1
Click to Show/Hide
|
||||
| Activity |
IC50 = 800000 nM
|
[30] | |||
| Compound Name |
2-[(3-Fluoro-4-methoxyphenyl)methylidene]propanedinitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Tyrphostin deriv. 6; CHEMBL57170; BDBM4276; Propanedinitrile, 2-[(3-fluoro-4-methoxyphenyl)methylene]-; MCK103015; AKOS008877580; (3-Fluoro-4-methoxybenzylidene)malononitrile
Click to Show/Hide
|
||||
| Activity |
IC50 = 800000 nM
|
[66] | |||
| Compound Name |
N-[4-(3-Bromo-phenylamino)-3-cyano-7-methoxy-quinolin-6-yl]-acrylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL324718; SCHEMBL6381201; BDBM50122583; N-[4-(3-bromoanilino)-3-cyano-7-methoxyquinolin-6-yl]prop-2-enamide; N-[4-[(3-Bromophenyl)amino]-3-cyano-7-methoxy-6-quinolinyl]-2-propenamide; N-[4-[(3-Bromophenyl)amino]-3-cyano-7-methoxy -6-quinolinyl]-2-propenamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 810027.94 nM
|
[93] | |||
| Compound Name |
1-Carboxy-1-cyano-2-(4-fluorophenyl)ethylene
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
NSC638135; (E)-2-cyano-3-(4-fluorophenyl)prop-2-enoic acid; 2-cyano-3-(4-fluorophenyl)prop-2-enoic acid; CHEMBL78184; BDBM4344; 4-Fluoro-alpha-cyanocinnamic acid; ZINC1625445; AKOS000263178; NSC-638135; 2-Cyano-3-(4-fluorophenyl)acrylic acid; benzylidenemalononitrile (BMN) deriv. 28; 2-Cyano-3-(4-fluorophenyl)propenoic acid; J3.658.130A; (2E)-2-cyano-3-(4-fluorophenyl)prop-2-enoic acid; (E)-2-Cyano-3-(4-fluorophenyl)-2-propenoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 833000 nM
|
[30] | |||
| Compound Name |
alpha-Cyano-4-methoxycinnamic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
(2E)-2-cyano-3-(4-methoxyphenyl)prop-2-enoic acid; 4-methoxybenzylidenecyanoacetic acid; (E)-2-cyano-3-(4-methoxyphenyl)prop-2-enoic acid; MFCD00051722; 1-carboxy-1-cyano-2-(4-methoxyphenyl)ethylene; (2e)-2-cyano-3-(4-methoxyphenyl)acrylic acid; NSC31629; CHEMBL77524; SCHEMBL782091; BDBM4343; 4-Methoxy-alpha-cyanocinnamic acid; alpha-cyano 4-methoxycinnamic acid; ZINC156538; SMSF0003775; 6138AH; NSC-31629; SBB028532; STK809530; AKOS001018352; CB14144; 2-cyano-3-(4-methoxyphenyl)acrylic acid; AS-60371; benzylidenemalononitrile (BMN) deriv. 27; BIM-0010971.P001; ST45187192; (E)-2-CYANO-3-(4-METHOXYPHENYL)ACRYLIC ACID
Click to Show/Hide
|
||||
| Activity |
IC50 = 833000 nM
|
[30] | |||
| Compound Name |
alpha-Cyanocinnamic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
alpha-Cyanocinnamate; 2-Cyano-3-phenylacrylic Acid; (E)-2-cyano-3-phenylprop-2-enoic acid; 2-Propenoic acid, 2-cyano-3-phenyl-; (2E)-2-cyano-3-phenylprop-2-enoic acid; a-cyanocinnamic acid; (2E)-2-cyano-3-phenylacrylic acid; 2-cyano-3-phenylprop-2-enoic acid; ALPHA-CYANOCINNAMICACID; NSC 298; EINECS 213-788-8; Cinnamic acid, alpha-cyano-; .alpha.-Cyanocinnamic acid; CHEMBL77595; SCHEMBL305982; 2-Cyano-3-phenyl-acrylic acid; BDBM4342; 2-Cyano-3-phenylpropenoic acid; GTPL11299; ZINC84158; HMS1757L09; (E)-2-Cyano-3-phenylacrylic acid; 5806AF; MFCD00016813; SBB028487; STL281379; AKOS000274287; .alpha.-Cyano-.beta.-phenylacrylic acid; AS-62210; benzylidenemalononitrile (BMN) deriv. 26; ST50189880; (2E)-2-Cyano-3-phenyl-2-propenoic acid #; 2-propenoic acid, 2-cyano-3-phenyl-, (2E)-; AF-213/30142035
Click to Show/Hide
|
||||
| Activity |
IC50 = 850000 nM
|
[30] | |||
| Compound Name |
2-(4-Hydroxy-3,5-dimethoxyphenyl)ethene-1,1,2-tricarbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL489148; BDBM50292519
Click to Show/Hide
|
||||
| Activity |
IC50 = 900000 nM
|
[29] | |||
| Compound Name |
N-[4-(3-Bromoanilino)-3-cyanoquinolin-6-yl]-4-(2-methoxyethoxy)but-2-ynamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL115440; SCHEMBL1895606; BDBM50148235; 3-(2-Methoxy-ethoxy)-propynoic acid [4-(3-bromo-phenylamino)-3-cyano-quinolin-6-yl]-amide; 4-(2-methoxy-ethoxy)-but-2-ynoic acid[4-(3-bromo-phenylamino)-3-cyano-quinolin-6-yl]-amide
Click to Show/Hide
|
||||
| Activity |
IC50 = 930036.51 nM
|
[93] | |||
| Compound Name |
N-[2-[3-(Dimethylamino)azetidine-1-yl]-4-methoxy-5-[4-(pyrazolo[1,5-a]pyridine-3-yl)-5-chloropyrimidine-2-ylamino]phenyl]acrylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3353405; SCHEMBL16668610; BDBM50029686
Click to Show/Hide
|
||||
| Activity |
IC50 = 938000 nM
|
[71] | |||
| Compound Name |
N-[4-[(3-Bromophenyl)amino]-3-cyano-6-quinolinyl]butynamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL283682; SCHEMBL6380849; CTK0J7512; DTXSID90432417; BDBM50122573; N-[4-(3-bromoanilino)-3-cyanoquinolin-6-yl]but-2-ynamide; 2-Butynamide, N-[4-[(3-bromophenyl)amino]-3-cyano-6-quinolinyl]-; N-[4-[(3-Bromophenyl)amino]-3-cyano-6-quinolinyl]-2-butynamide; But-2-ynoic acid [4-(3-bromo-phenylamino)-3-cyano-quinolin-6-yl]-amide
Click to Show/Hide
|
||||
| Activity |
IC50 = 940156.17 nM
|
[93] | |||
| Compound Name |
N-[4-(3-Bromoanilino)-3-cyanoquinolin-6-yl]-4-methoxybut-2-ynamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL114593; SCHEMBL6381504; BDBM50122582; N-[4-[(3-Bromophenyl)amino]-3-cyano-6-quinolinyl]-4-methoxy-2-butynamide; 4-Methoxy-but-2-ynoic acid [4-(3-bromo-phenylamino)-3-cyano-quinolin-6-yl]-amide
Click to Show/Hide
|
||||
| Activity |
IC50 = 960063.59 nM
|
[93] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Design, synthesis, and evaluations of substituted 3-[(3- or 4-carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as inhibitors of VEGF, FGF, and P... J Med Chem. 1999 Dec 16;42(25):5120-30. | ||||
| REF 2 | Potent and selective inhibitors of the Abl-kinase: phenylamino-pyrimidine (PAP) derivatives. Bioorg Med Chem Lett. 1997 Jan 21;7(2):187-92. | ||||
| REF 3 | Structure-based design of a potent, selective, and irreversible inhibitor of the catalytic domain of the erbB receptor subfamily of protein tyrosine kinases. J Med Chem. 1997 Mar 28;40(7):1130-5. | ||||
| REF 4 | Discovery and structure-activity studies of a novel series of pyrido[2,3-d]pyrimidine tyrosine kinase inhibitors. Bioorg Med Chem Lett. 1997 Sep 23;7(18):2415-20. | ||||
| REF 5 | Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1-((2S,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one (PF-06651600) Allowing for the Interrogation of JAK3 Signaling in Humans. J Med Chem. 2017 Mar 9;60(5):1971-1993. | ||||
| REF 6 | Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling. Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):19936-41. | ||||
| REF 7 | Discovery and optimization of selective FGFR4 inhibitors via scaffold hopping. Bioorg Med Chem Lett. 2017 Jun 1;27(11):2420-2423. | ||||
| REF 8 | Synthesis and biological activity of 5-chloro-N4-substituted phenyl-9H-pyrimido[4,5-b]indole-2,4-diamines as vascular endothelial growth factor receptor-2 inhibitors and antiangiogenic agents. Bioorg Med Chem. 2013 Apr 1;21(7):1857-64. | ||||
| REF 9 | Structural studies on bioactive compounds. 23. Synthesis of polyhydroxylated 2-phenylbenzothiazoles and a comparison of their cytotoxicities and pharmacological properties with genistein and quercetin. J Med Chem. 1994 May 27;37(11):1689-95. | ||||
| REF 10 | Design and synthesis of potent, selective, and orally bioavailable tetrasubstituted imidazole inhibitors of p38 mitogen-activated protein kinase. J Med Chem. 1999 Jun 17;42(12):2180-90. | ||||
| REF 11 | Discovery and SAR of 2-amino-5-(thioaryl)thiazoles as potent and selective Itk inhibitors. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3706-12. | ||||
| REF 12 | Synthesis and biological evaluation of 3-ethylidene-1,3-dihydro-indol-2-ones as novel checkpoint 1 inhibitors. Bioorg Med Chem Lett. 2006 Jan 15;16(2):421-6. | ||||
| REF 13 | Dianilinophthalimides: potent and selective, ATP-competitive inhibitors of the EGF-receptor protein tyrosine kinase. J Med Chem. 1994 Apr 1;37(7):1015-27. | ||||
| REF 14 | Synthesis and biological evaluations of 3-substituted indolin-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases. J Med Chem. 1998 Jul 2;41(14):2588-603. | ||||
| REF 15 | Identification of substituted 3-[(4,5,6, 7-tetrahydro-1H-indol-2-yl)methylene]-1,3-dihydroindol-2-ones as growth factor receptor inhibitors for VEGF-R2 (Flk-1/KDR), FGF-R1, and PDGF-Rbeta tyrosine kinases. J Med Chem. 2000 Jul 13;43(14):2655-63. | ||||
| REF 16 | 1-Acyl-1H-[1,2,4]triazole-3,5-diamine analogues as novel and potent anticancer cyclin-dependent kinase inhibitors: synthesis and evaluation of biological activities. J Med Chem. 2005 Jun 30;48(13):4208-11. | ||||
| REF 17 | A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20523-8. | ||||
| REF 18 | A novel series of 4-phenoxyquinolines: potent and highly selective inhibitors of PDGF receptor autophosphorylation. Bioorg Med Chem Lett. 1997 Dec 2;7(23):2935-40. | ||||
| REF 19 | 4-(Phenylamino)pyrrolopyrimidines: potent and selective, ATP site directed inhibitors of the EGF-receptor protein tyrosine kinase. J Med Chem. 1996 Jun 7;39(12):2285-92. | ||||
| REF 20 | Tyrosine kinase inhibitors. 6. Structure-activity relationships among N- and 3-substituted 2,2'-diselenobis(1H-indoles) for inhibition of protein tyrosine kinases and comparative in vitro and in vivo studies against selected sulfur congeners. J Med Chem. 1997 Feb 14;40(4):413-26. | ||||
| REF 21 | 2-Substituted aminopyrido[2,3-d]pyrimidin-7(8H)-ones. structure-activity relationships against selected tyrosine kinases and in vitro and in vivo anticancer activity. J Med Chem. 1998 Aug 13;41(17):3276-92. | ||||
| REF 22 | Inhibition of the EGF-stimulated cellular proliferation of ER 22 cells by hydroxybiphenyl derivatives. J Med Chem. 1995 Nov 10;38(23):4693-703. | ||||
| REF 23 | The synthesis and SAR of new 4-(N-alkyl-N-phenyl)amino-6,7-dimethoxyquinazolines and 4-(N-alkyl-N-phenyl)aminopyrazolo[3,4-d]pyrimidines, inhibitors of CSF-1R tyrosine kinase activity. Bioorg Med Chem Lett. 1997 Feb 18;7(4):421-4. | ||||
| REF 24 | Identification of a selective inhibitor of transforming growth factor -activated kinase 1 by biosensor-based screening of focused libraries. Bioorg Med Chem Lett. 2017 Feb 15;27(4):1031-1036. | ||||
| REF 25 | N4-(3-Bromophenyl)-7-(substituted benzyl) pyrrolo[2,3-d]pyrimidines as potent multiple receptor tyrosine kinase inhibitors: design, synthesis, and in vivo evaluation. Bioorg Med Chem. 2012 Apr 1;20(7):2444-54. | ||||
| REF 26 | Development of a binding model to protein tyrosine kinases for substituted pyrido[2,3-d]pyrimidine inhibitors. J Med Chem. 1998 May 21;41(11):1752-63. | ||||
| REF 27 | Discovery of (R,E)-N-(7-Chloro-1-(1-[4-(dimethylamino)but-2-enoyl]azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide (EGF816), a Novel, Potent, and WT Sparing Covalent Inhibitor of Oncogenic (L858R, ex19del) and Resistant (T790M) EGFR Mutants for the Treatment of EGFR Mutant Non-Small-Cell Lung Cancers. J Med Chem. 2016 Jul 28;59(14):6671-89. | ||||
| REF 28 | Discovery of novel, dual mechanism ERK inhibitors by affinity selection screening of an inactive kinase. J Med Chem. 2014 Nov 13;57(21):8817-26. | ||||
| REF 29 | Protein-tyrosine kinase inhibition: mechanism-based discovery of antitumor agents. J Nat Prod. 1992 Nov;55(11):1529-60. | ||||
| REF 30 | Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors. J Med Chem. 1989 Oct;32(10):2344-52. | ||||
| REF 31 | Angiogenesis inhibitors identified by cell-based high-throughput screening: synthesis, structure-activity relationships and biological evaluation of 3-[(E)-styryl]benzamides that specifically inhibit endothelial cell proliferation. Bioorg Med Chem. 2012 Feb 15;20(4):1442-60. | ||||
| REF 32 | Synthesis and structure-activity relationships of N-benzyl-N-(X-2-hydroxybenzyl)-N'-phenylureas and thioureas as antitumor agents. Bioorg Med Chem. 2010 Jan 1;18(1):305-13. | ||||
| REF 33 | Structure-activity relationships in a series of 5-[(2,5-dihydroxybenzyl)amino]salicylate inhibitors of EGF-receptor-associated tyrosine kinase: importance of additional hydrophobic aromatic interactions. J Med Chem. 1994 Mar 18;37(6):845-59. | ||||
| REF 34 | Serotonin derivatives as a new class of non-ATP-competitive receptor tyrosine kinase inhibitors. Bioorg Med Chem. 2010 May 15;18(10):3387-402. | ||||
| REF 35 | The sulfamide moiety affords higher inhibitory activity and oral bioavailability to a series of coumarin dual selective RAF/MEK inhibitors. Bioorg Med Chem Lett. 2013 Dec 1;23(23):6223-7. | ||||
| REF 36 | Tyrphostins. 3. Structure-activity relationship studies of alpha-substituted benzylidenemalononitrile 5-S-aryltyrphostins. J Med Chem. 1993 Nov 12;36(23):3556-64. | ||||
| REF 37 | 9-substituted 6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazoles as highly selective and potent anaplastic lymphoma kinase inhibitors. J Med Chem. 2011 Sep 22;54(18):6286-94. | ||||
| REF 38 | Discovery of 6-benzyloxyquinolines as c-Met selective kinase inhibitors. Bioorg Med Chem Lett. 2010 Feb 15;20(4):1405-9. | ||||
| REF 39 | Computer-aided design, synthesis, and biological evaluation of new indole-2-carboxamide derivatives as PI3Kalpha/EGFR inhibitors. Bioorg Med Chem Lett. 2016 Jun 1;26(11):2685-90. | ||||
| REF 40 | Recent Progress of Small-Molecule Epidermal Growth Factor Receptor (EGFR) Inhibitors against C797S Resistance in Non-Small-Cell Lung Cancer. J Med Chem. 2018 May 24;61(10):4290-4300. | ||||
| REF 41 | Hit-to-lead optimization of 1,4-dihydroindeno[1,2-c]pyrazoles as a novel class of KDR kinase inhibitors. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4371-5. | ||||
| REF 42 | Imidazo[1,2-a]pyrazine diaryl ureas: inhibitors of the receptor tyrosine kinase EphB4. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6991-5. | ||||
| REF 43 | Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. Nat Chem Biol. 2008 Nov;4(11):691-9. | ||||
| REF 44 | Thienopyrimidine ureas as novel and potent multitargeted receptor tyrosine kinase inhibitors. J Med Chem. 2005 Sep 22;48(19):6066-83. | ||||
| REF 45 | Synthesis, biological evaluation and molecular docking studies of amide-coupled benzoic nitrogen mustard derivatives as potential antitumor agents. Bioorg Med Chem. 2010 Jan 15;18(2):880-6. | ||||
| REF 46 | Thio- and oxoflavopiridols, cyclin-dependent kinase 1-selective inhibitors: synthesis and biological effects. J Med Chem. 2000 Nov 2;43(22):4126-34. | ||||
| REF 47 | Design, synthesis, docking and QSAR study of substituted benzimidazole linked oxadiazole as cytotoxic agents, EGFR and erbB2 receptor inhibitors. Eur J Med Chem. 2017 Jan 27;126:853-869. | ||||
| REF 48 | Rational design of 4,5-disubstituted-5,7-dihydro-pyrrolo[2,3-d]pyrimidin-6-ones as a novel class of inhibitors of epidermal growth factor receptor (EGF-R) and Her2(p185(erbB)) tyrosine kinases. Bioorg Med Chem Lett. 2002 Aug 19;12(16):2153-7. | ||||
| REF 49 | N4-Aryl-6-substitutedphenylmethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as receptor tyrosine kinase inhibitors. Bioorg Med Chem. 2012 Jan 15;20(2):910-4. | ||||
| REF 50 | 5-Cyanopyrimidine derivatives as a novel class of potent, selective, and orally active inhibitors of p38alpha MAP kinase. J Med Chem. 2005 Oct 6;48(20):6261-70. | ||||
| REF 51 | High-affinity epidermal growth factor receptor (EGFR) irreversible inhibitors with diminished chemical reactivities as positron emission tomography (PET)-imaging agent candidates of EGFR overexpressing tumors. J Med Chem. 2005 Aug 11;48(16):5337-48. | ||||
| REF 52 | The preparation and sar of 4-(anilino), 4-(phenoxy), and 4-(thiophenoxy)-quinazolines: Inhibitors of p56lck and EGF-R tyrosine kinase activity. Bioorg Med Chem Lett. 1997 Feb 18;7(4):417-20. | ||||
| REF 53 | Design, synthesis, and X-ray crystal structures of 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase i... Bioorg Med Chem. 2009 Oct 15;17(20):7324-36. | ||||
| REF 54 | Discovery and evaluation of N-cyclopropyl- 2,4-difluoro-5-((2-(pyridin-2-ylamino)thiazol-5- ylmethyl)amino)benzamide (BMS-605541), a selective and orally efficacious inhibitor of vascular endothelial growth factor receptor-2. J Med Chem. 2006 Jun 29;49(13):3766-9. | ||||
| REF 55 | Naphthofuroquinone derivatives: inhibition of receptor tyrosine kinases. Bioorg Med Chem Lett. 2006 Feb;16(3):737-42. | ||||
| REF 56 | Sulfonylbenzoyl-nitrostyrenes: potential bisubstrate type inhibitors of the EGF-receptor tyrosine protein kinase. J Med Chem. 1991 Aug;34(8):2328-37. | ||||
| REF 57 | Recent updates on third generation EGFR inhibitors and emergence of fourth generation EGFR inhibitors to combat C797S resistance. Eur J Med Chem. 2017 Dec 15;142:32-47. | ||||
| REF 58 | Towards predictive inhibitor design for the EGFR autophosphorylation activity. Eur J Med Chem. 2008 Apr;43(4):781-91. | ||||
| REF 59 | Tyrosine kinase inhibitors. 2. Synthesis of 2,2'-dithiobis(1H-indole-3-alkanamides) and investigation of their inhibitory activity against epidermal growth factor receptor and pp60v-src protein tyrosine kinases. J Med Chem. 1994 Mar 4;37(5):598-609. | ||||
| REF 60 | Synthesis and antitumor activities of 1,2,3-triazines and their benzo- and heterofused derivatives. Eur J Med Chem. 2017 Dec 15;142:74-86. | ||||
| REF 61 | Tyrosine kinase inhibitors. 1. Structure-activity relationships for inhibition of epidermal growth factor receptor tyrosine kinase activity by 2,3-dihydro-2-thioxo-1H-indole-3-alkanoic acids and 2,2'-dithiobis(1H-indole-3-alkanoic acids). J Med Chem. 1993 Aug 20;36(17):2459-69. | ||||
| REF 62 | Design, synthesis and evaluation of 2-amino-4-m-bromoanilino-6-arylmethyl-7H-pyrrolo[2,3-d]pyrimidines as tyrosine kinase inhibitors and antiangiogenic agents. Bioorg Med Chem. 2010 Jul 15;18(14):5261-73. | ||||
| REF 63 | Quinazoline and tetrahydropyridothieno[2,3-d]pyrimidine derivatives as irreversible EGFR tyrosine kinase inhibitors: influence of the position 4 substituent. Medchemcomm. 2013;4:1202-7. | ||||
| REF 64 | Receptor-guided alignment-based comparative 3D-QSAR studies of benzylidene malonitrile tyrphostins as EGFR and HER-2 kinase inhibitors. J Med Chem. 2003 Oct 23;46(22):4657-68. | ||||
| REF 65 | Tyrosine kinase inhibitors. 3. Structure-activity relationships for inhibition of protein tyrosine kinases by nuclear-substituted derivatives of 2,2'-dithiobis(1-methyl-N-phenyl-1H-indole-3-carboxamide). J Med Chem. 1994 Jun 24;37(13):2033-42. | ||||
| REF 66 | Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine... J Med Chem. 1991 Jun;34(6):1896-907. | ||||
| REF 67 | Synthesis and biological activity of N(4)-phenylsubstituted-6-(2,4-dichloro phenylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as vascular endo... Bioorg Med Chem. 2010 May 15;18(10):3575-87. | ||||
| REF 68 | Novel acetamidothiazole derivatives: synthesis and in vitro anticancer evaluation. Eur J Med Chem. 2013 Nov;69:908-19. | ||||
| REF 69 | Synthesis and biological evaluation of 7-substituted-1-(3-bromophenylamino)isoquinoline-4-carbonitriles as inhibitors of myosin light chain kinase and epidermal growth factor receptor. Bioorg Med Chem. 2011 Jan 1;19(1):429-39. | ||||
| REF 70 | The contribution of a 2-amino group on receptor tyrosine kinase inhibition and antiangiogenic activity in 4-anilinosubstituted pyrrolo[2,3-d]pyrimidines. Bioorg Med Chem Lett. 2010 May 15;20(10):3177-81. | ||||
| REF 71 | Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor. J Med Chem. 2014 Oct 23;57(20):8249-67. | ||||
| REF 72 | Use of a pharmacophore model for the design of EGFR tyrosine kinase inhibitors: isoflavones and 3-phenyl-4(1H)-quinolones. J Med Chem. 1999 Mar 25;42(6):1018-26. | ||||
| REF 73 | Synthesis and biological activities of topoisomerase I inhibitors, 6-N-amino analogues of NB-506. Bioorg Med Chem Lett. 1999 May 3;9(9):1219-24. | ||||
| REF 74 | Novel 2-chloro-4-anilino-quinazoline derivatives as EGFR and VEGFR-2 dual inhibitors. Eur J Med Chem. 2014 Jan;71:1-14. | ||||
| REF 75 | Novel tricyclic azepine derivatives: Biological evaluation of pyrimido[4,5-b]-1,4-benzoxazepines, thiazepines, and diazepines as inhibitors of the epidermal growth factor receptor tyrosine kinase. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5102-6. | ||||
| REF 76 | Tyrosine kinase inhibitors. 7. 7-Amino-4-(phenylamino)- and 7-amino-4-[(phenylmethyl)amino]pyrido[4,3-d]pyrimidines: a new class of inhibitors of the tyrosine kinase activity of the epidermal growth factor receptor. J Med Chem. 1995 Sep 15;38(19):3780-8. | ||||
| REF 77 | Novel oxazolo[4,5-g]quinazolin-2(1H)-ones: dual inhibitors of EGFR and Src protein tyrosine kinases. Eur J Med Chem. 2012 Sep;55:39-48. | ||||
| REF 78 | Design, synthesis and biological study of novel pyrido[2,3-d]pyrimidine as anti-proliferative CDK2 inhibitors. Eur J Med Chem. 2011 Dec;46(12):5825-32. | ||||
| REF 79 | [(Alkylamino)methyl]acrylophenones: potent and selective inhibitors of the epidermal growth factor receptor protein tyrosine kinase. J Med Chem. 1995 Jun 23;38(13):2441-8. | ||||
| REF 80 | Inhibitory activity and selectivity of staurosporine derivatives towards protein kinase C. Bioorg Med Chem Lett. 1994 Feb 10;4(3):399-404. | ||||
| REF 81 | Structural studies on bioactive compounds. 32. Oxidation of tyrphostin protein tyrosine kinase inhibitors with hypervalent iodine reagents. J Med Chem. 2000 Apr 20;43(8):1550-62. | ||||
| REF 82 | Discovery of novel EGFR tyrosine kinase inhibitors by structure-based virtual screening. Bioorg Med Chem Lett. 2012 Jun 15;22(12):4004-9. | ||||
| REF 83 | Selective inhibition of the tyrosine kinase pp60src by analogs of 5,10-dihydropyrimido[4,5-b]quinolin-4(1H)-one. Bioorg Med Chem Lett. 1995 May 4;5(9):1007-10. | ||||
| REF 84 | Phenylamino-pyrimidine (PAP) - derivatives: a new class of potent and highly selective PDGF-receptor autophosphorylation inhibitors. Bioorg Med Chem Lett. 1996 Jun 4;6(11):1221-6. | ||||
| REF 85 | Tyrphostins. 6. Dimeric benzylidenemalononitrile tyrophostins: potent inhibitors of EGF receptor tyrosine kinase in vitro. J Med Chem. 1996 Dec 6;39(25):4905-11. | ||||
| REF 86 | Design, synthesis and characterization of N9/N7-substituted 6-aminopurines as VEGF-R and EGF-R inhibitors. Eur J Med Chem. 2009 Apr;44(4):1788-93. | ||||
| REF 87 | Discovery of novel selective inhibitors for EGFR-T790M/L858R. Bioorg Med Chem Lett. 2012 Feb 1;22(3):1365-70. | ||||
| REF 88 | Discovery of (E)-5-(benzylideneamino)-1H-benzo[d]imidazol-2(3H)-one derivatives as inhibitors for PTK6. Bioorg Med Chem Lett. 2014 Oct 1;24(19):4659-4663. | ||||
| REF 89 | Synthesis and biological evaluation of pyrrolopyridazine derivatives as novel HER-2 tyrosine kinase inhibitors. Bioorg Med Chem Lett. 2009 Nov 15;19(22):6437-40. | ||||
| REF 90 | Design and synthesis of quinazolinones as EGFR inhibitors to overcome EGFR resistance obstacle. Bioorg Med Chem. 2017 May 15;25(10):2713-2723. | ||||
| REF 91 | Design, biological evaluation and 3D QSAR studies of novel dioxin-containing triaryl pyrazoline derivatives as potential B-Raf inhibitors. Bioorg Med Chem. 2016 Jul 1;24(13):3052-3061. | ||||
| REF 92 | N2-Trimethylacetyl substituted and unsubstituted-N4-phenylsubstituted-6-(2-pyridin-2-ylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines: design, cellular receptor tyrosine kinase inhibitory activities and in vivo evaluation as antiangiogenic, antimetastatic and antitumor agents. Bioorg Med Chem. 2013 Mar 1;21(5):1312-23. | ||||
| REF 93 | 3D QSAR STUDIES OF INHIBITORS OF EPIDERMAL GROWTH FACTOR RECEPTOR [EGFR] USING CoMFA AND GFA METHODOLOGIES. Med Chem Res. 2004;13:605-18. | ||||
| REF 94 | Synthesis and structure-activity studies of a series of [(hydroxybenzyl)amino]salicylates as inhibitors of EGF receptor-associated tyrosine kinase activity. J Med Chem. 1993 Dec 10;36(25):4094-8. | ||||
| REF 95 | US patent application no. 9422297B2, Tricyclic compounds having cytostatic and/or cytotoxic activity and methods of use thereof | ||||
| REF 96 | Evaluation of the anti-malarial activity and cytotoxicity of 2,4-diamino-pyrimidine-based kinase inhibitors. Eur J Med Chem. 2016 Nov 29;124:896-905. | ||||
| REF 97 | Potent and selective inhibitors of platelet-derived growth factor receptor phosphorylation. 1. Synthesis, structure-activity relationship, and biological effects of a new class of quinazoline derivatives. J Med Chem. 2002 Jul 4;45(14):3057-66. | ||||
| REF 98 | Synthesis and antiproliferative activity of 6,7-disubstituted-4-phenoxyquinoline derivatives bearing the 2-oxo-4-chloro-1,2-dihydroquinoline-3-carboxamide moiety. Bioorg Med Chem Lett. 2016 Apr 1;26(7):1794-8. | ||||
| REF 99 | Novel antiproliferative agents derived from lavendustin A. J Med Chem. 1994 Nov 25;37(24):4079-84. | ||||
| REF 100 | Synthesis and biochemical evaluation of a series of aminoflavones as potential inhibitors of protein-tyrosine kinases p56lck, EGFr, and p60v-src. J Med Chem. 1994 Sep 30;37(20):3353-62. | ||||
| REF 101 | Design, synthesis, and biological evaluation of novel 4-anilinoquinazoline derivatives bearing amino acid moiety as potential EGFR kinase inhibitors. Eur J Med Chem. 2017 Apr 21;130:393-405. | ||||
| REF 102 | Discovery and optimization of novel 4-phenoxy-6,7-disubstituted quinolines possessing semicarbazones as c-Met kinase inhibitors. Bioorg Med Chem. 2013 Sep 1;21(17):5246-60. | ||||
| REF 103 | Tyrosine kinase inhibitors. 4. Structure-activity relationships among N- and 3-substituted 2,2'-dithiobis(1H-indoles) for in vitro inhibition of receptor and nonreceptor protein tyrosine kinases. J Med Chem. 1995 Jan 6;38(1):58-67. | ||||
| REF 104 | Potent and selective inhibitors of PDGF receptor phosphorylation. 2. Synthesis, structure activity relationship, improvement of aqueous solubility, and biological effects of 4-[4-(N-substituted (thio)carbamoyl)-1-piperazinyl]-6,7-dimethoxyquinazoline derivatives. J Med Chem. 2002 Sep 26;45(20):4513-23. | ||||
| REF 105 | In vitro and in vivo characterization of a benzofuran derivative, a potential anticancer agent, as a novel Aurora B kinase inhibitor. Eur J Med Chem. 2015 Jan 7;89:310-9. | ||||
| REF 106 | Tyrosine kinase inhibitors. 5. Synthesis and structure-activity relationships for 4-[(phenylmethyl)amino]- and 4-(phenylamino)quinazolines as poten... J Med Chem. 1995 Sep 1;38(18):3482-7. | ||||
| REF 107 | Tyrosine kinase inhibitors. 11. Soluble analogues of pyrrolo- and pyrazoloquinazolines as epidermal growth factor receptor inhibitors: synthesis, biological evaluation, and modeling of the mode of binding. J Med Chem. 1997 May 9;40(10):1519-29. | ||||
| REF 108 | Tyrosine kinase inhibitors. 16. 6,5,6-tricyclic benzothieno[3, 2-d]pyrimidines and pyrimido[5,4-b-] and -[4,5-b]?ndoles as potent inhibitors of the epidermal growth factor receptor tyrosine kinase. J Med Chem. 1999 Dec 30;42(26):5464-74. | ||||
| REF 109 | 5-Substituted pyrido[2,3-d]pyrimidine, an inhibitor against three receptor tyrosine kinases. Bioorg Med Chem Lett. 2009 Feb 1;19(3):745-50. | ||||
| REF 110 | Discovery of 2-phenylamino-imidazo[4,5-h]isoquinolin-9-ones: a new class of inhibitors of lck kinase. J Med Chem. 2002 Aug 1;45(16):3394-405. | ||||
| REF 111 | Design, synthesis, and biological evaluation of novel pyrimidine derivatives as CDK2 inhibitors. Eur J Med Chem. 2010 Mar;45(3):1158-66. | ||||
| REF 112 | Use of a pharmacophore model for the design of EGF-R tyrosine kinase inhibitors: 4-(phenylamino)pyrazolo[3,4-d]pyrimidines. J Med Chem. 1997 Oct 24;40(22):3601-16. | ||||
| REF 113 | Design, synthesis and biological evaluation of novel 4-phenoxy-6,7-disubstituted quinolines possessing (thio)semicarbazones as c-Met kinase inhibitors. Bioorg Med Chem. 2016 Mar 15;24(6):1331-45. | ||||
| REF 114 | Development of natural product-derived receptor tyrosine kinase inhibitors based on conservation of protein domain fold. J Med Chem. 2003 Jul 3;46(14):2917-31. | ||||
| REF 115 | Macrocyclic bisindolylmaleimides as inhibitors of protein kinase C and glycogen synthase kinase-3. Bioorg Med Chem Lett. 2003 Sep 15;13(18):3049-53. | ||||
| REF 116 | Discovery of novel 2-substituted-4-phenoxypyridine derivatives as potential antitumor agents. Bioorg Med Chem Lett. 2018 Feb 1;28(3):254-259. | ||||
| REF 117 | Design and biological evaluation of novel 4-(2-fluorophenoxy)quinoline derivatives bearing an imidazolone moiety as c-Met kinase inhibitors. Bioorg Med Chem. 2015 Aug 1;23(15):4410-4422. | ||||
| REF 118 | 3-Acyl-2,6-diaminopyridines as cyclin-dependent kinase inhibitors: synthesis and biological evaluation. Bioorg Med Chem Lett. 2005 May 2;15(9):2221-4. | ||||
| REF 119 | Synthesis and bioevaluation and doking study of 1H-pyrrolo[2,3-b]pyridine derivatives bearing aromatic hydrazone moiety as c-Met inhibitors. Eur J Med Chem. 2018 Feb 10;145:315-327. | ||||
| REF 120 | 2,6,9-trisubstituted purines: optimization towards highly potent and selective CDK1 inhibitors. Bioorg Med Chem Lett. 1999 Jan 4;9(1):91-6. | ||||
| REF 121 | Arylamides of hydroxylated isoquinolines as protein-tyrosine kinase inhibitors. Bioorg Med Chem Lett. 1992 Dec;2(12):1771-4. | ||||
| REF 122 | Discovery of novel 6,7-disubstituted-4-phenoxyquinoline derivatives bearing 5-(aminomethylene)pyrimidine-2,4,6-trione moiety as c-Met kinase inhibitors. Bioorg Med Chem. 2014 Feb 15;22(4):1236-49. | ||||
| REF 123 | Design and optimization of novel 4-(2-fluorophenoxy)quinoline derivatives bearing a hydrazone moiety as c-Met kinase inhibitors. Eur J Med Chem. 2014 Nov 24;87:508-18. | ||||
| REF 124 | Click chemistry inspired one-pot synthesis of 1,4-disubstituted 1,2,3-triazoles and their Src kinase inhibitory activity. Bioorg Med Chem Lett. 2011 Jan 1;21(1):449-52. | ||||
| REF 125 | Synthesis and evaluation of novel pyrimidine-based dual EGFR/Her-2 inhibitors. Bioorg Med Chem Lett. 2011 Mar 15;21(6):1601-6. | ||||
| REF 126 | N-Acetyl-3-aminopyrazoles block the non-canonical NF-kB cascade by selectively inhibiting NIK. Medchemcomm. 2018 Apr 12;9(6):963-968. | ||||
| REF 127 | Optimization of potent DFG-in inhibitors of platelet derived growth factor receptor (PDGF-R) guided by water thermodynamics. J Med Chem. 2015 Jan 8;58(1):170-82. | ||||
| REF 128 | Anthraquinones and betaenone derivatives from the sponge-associated fungus Microsphaeropsis species: novel inhibitors of protein kinases. J Nat Prod. 2000 Jun;63(6):739-45. | ||||
| REF 129 | Synthesis and evaluation of 5-(arylthio)-9H-pyrimido[4,5-b]indole-2,4-diamines as receptor tyrosine kinase and thymidylate synthase inhibitors and as antitumor agents. Bioorg Med Chem Lett. 2017 Apr 1;27(7):1602-1607. | ||||
| REF 130 | Synthesis and biological activities of topoisomerase I inhibitors, 6-arylmethylamino analogues of edotecarin. J Med Chem. 2009 May 28;52(10):3225-37. | ||||
| REF 131 | Design, synthesis and biological evaluation of substituted pyrrolo[2,3-d]pyrimidines as multiple receptor tyrosine kinase inhibitors and antiangiogenic agents. Bioorg Med Chem. 2008 May 15;16(10):5514-28. | ||||
| REF 132 | Noncovalent Mutant Selective Epidermal Growth Factor Receptor Inhibitors: A Lead Optimization Case Study. J Med Chem. 2015 Nov 25;58(22):8877-95. | ||||
| REF 133 | Multitargeted drug development: Discovery and profiling of dihydroxy substituted 1-aza-9-oxafluorenes as lead compounds targeting Alzheimer disease relevant kinases. Bioorg Med Chem Lett. 2012 Nov 15;22(22):6914-8. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.