Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T63359 | Target Info | |||
| Target Name | Bacterial UDP-N-acetylenolpyruvylglucosamine reductase (Bact murB) | ||||
| Synonyms |
UDP-N-acetylmuramate dehydrogenase; MurB
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| Target Type | Literature-reported Target | ||||
| Gene Name | Bact murB | ||||
| Biochemical Class | Short-chain dehydrogenases reductase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 6 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
1,2-Bis-(4-chloro-phenyl)-4-methyl-4-(6-phenyl-hexyl)-pyrazolidine-3,5-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL189679; BDBM50166484
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| Activity |
IC50 ~ 50000 nM
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[1] | |||
| Compound Name |
1,2-Bis-(4-chloro-phenyl)-5-[2-(2,4-difluoro-phenyl)-2-oxo-ethoxy]-4-methyl-pyrazolidin-3-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL363203; BDBM50166502
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
4-[1,2-Bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carbonyl]aminobenzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL217408; BDBM50195575
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| Activity |
IC50 ~ 52000 nM
|
[2] | |||
| Compound Name |
N-(4-Chlorophenyl)-3-hydroxy-5-oxo-1,2-diphenyl-pyrazole-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL384106; BDBM50195580; 5-hydroxy-3-oxo-1,2-diphenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid (4-chloro-phenyl)amide
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| Activity |
IC50 = 54000 nM
|
[2] | |||
| Compound Name |
3-Hydroxy-5-oxo-N,1,2-triphenyl-pyrazole-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL217127; BDBM50195582; 5-hydroxy-3-oxo-1,2-diphenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid phenylamide
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| Activity |
IC50 = 54000 nM
|
[2] | |||
| Compound Name |
N,1,2-Tris(4-chlorophenyl)-3-hydroxy-N-methyl-5-oxopyrazole-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL276644; BDBM50195574; 1,2-bis(4-chlorophenyl)-5-hydroxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid methylphenylamide
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| Activity |
IC50 ~ 55000 nM
|
[2] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | 4-Alkyl and 4,4'-dialkyl 1,2-bis(4-chlorophenyl)pyrazolidine-3,5-dione derivatives as new inhibitors of bacterial cell wall biosynthesis. Bioorg Med Chem Lett. 2005 May 16;15(10):2527-31. | ||||
| REF 2 | Pyrazolidine-3,5-diones and 5-hydroxy-1H-pyrazol-3(2H)-ones, inhibitors of UDP-N-acetylenolpyruvyl glucosamine reductase. J Med Chem. 2006 Oct 5;49(20):6027-36. | ||||
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