Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T64553 | Target Info | |||
| Target Name | Tyrosine-protein kinase ZAP-70 (ZAP-70) | ||||
| Synonyms |
Syk-related tyrosine kinase; SRK; 70 kDa zeta-chain associated protein
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| Target Type | Patented-recorded Target | ||||
| Gene Name | ZAP70 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 28 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Flavopiridol
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|
Phase 2 | Compound Info | ||
| Synonyms |
FLAVO; Alvocidib [INN]; Flavopiridol hydrochloride; L 868275; HMR-1275; L-868275; L86-8275; HMR-1275, Alvocidib, L868275, Flavopiridol; (-)-cis-5,7-Dihydroxy-2-(2-chlorophenyl)-8-(4-(3-hydroxy-1-methyl)piperidinyl)-4H-1-benzopyran-4-one; 2-(2-CHLORO-PHENYL)-5,7-DIHYDROXY-8-(3-HYDROXY-1-METHYL-PIPERIDIN-4-YL)-4H-BENZOPYRAN-4-ONE; 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]chromen-4-one
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
BMS-509744
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Investigative | Compound Info | ||
| Synonyms |
BMS-509744; 439575-02-7; BMS 509744; CHEMBL209148; N-(5-((5-(4-Acetylpiperazine-1-carbonyl)-4-methoxy-2-methylphenyl)thio)thiazol-2-yl)-4-(((3,3-dimethylbutan-2-yl)amino)methyl)benzamide; N-[5-[5-(4-acetylpiperazine-1-carbonyl)-4-methoxy-2-methylphenyl]sulfanyl-1,3-thiazol-2-yl]-4-[(3,3-dimethylbutan-2-ylamino)methyl]benzamide; GTPL9994; SCHEMBL14460651; KS-00001CVA; CHEBI:91404; MolPort-039-101-283; C32H41N5O4S2; BMS509744; BDBM50186460; 3499AH; compound 3 [PMID:16682193]; AKOS025142036; NCGC00229512-02; NCGC00229512-01
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
Lck inhibitor
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Investigative | Compound Info | ||
| Synonyms |
213743-31-8; 7-Cyclopentyl-5-(4-phenoxy)phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine; CHEMBL47940; KIN001-051; RK-24466; 7-Cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine; 4-Amino-5-(4-Phenoxyphenyl)-7h-Pyrrolo[2,3-D]pyrimidin-7-Yl-Cyclopentane; 7-cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine; 4-Amino-5-(4-phenoxyphenyl)-7H-pyrrolo[3,2-d]pyrimidin-7-yl-cyclopentane; 3vry; 3gen; B43; NCGC00015280-01; Lopac-C-8863; AC1O7G1S; Lopac0_000450; MLS002153184
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
3-({4-[(2,2-Dimethylpropyl)(methyl)amino]-6-(4-methyl-1,4-diazepan-1-yl)-1,3,5-triazin-2-yl}amino)-N-methoxy-4-methylbenzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL225088; SCHEMBL4336699; BDBM16316; triaminotriazine aniline amide inhibitor, 1
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
3,10,13,16,23-Pentaazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,22}]tricosa-1(23),2,4(9),5,7,11(15),17(22),18,20-nonaen-12-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL573026; SCHEMBL13431705; BDBM50300400; 1,1'-(2-Oxo-3-pyrroline-3,4-diyl)-2,2'-bi[1H-benzimidazole]
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| Activity |
IC50 = 50000 nM
|
[5] | |||
| Compound Name |
3-[4-Amino-5-(4-phenoxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclopentanol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL69129; 3-(4-Amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-1-cyclopentanol; 3-[4-amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-1-cyclopentanol; SCHEMBL6861201; BDBM50092224; 3-[4-amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]cyclopentan-1-ol; 3-[4-Amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]cyclopentanol; 3-[4-Amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidine-7-yl]cyclopentanol; 3-[4-amino-5-(4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclopentan-1-ol
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
Benzeneacetamide, N-(5-(((5-(1,1-dimethylethyl)-2-oxazolyl)methyl)thio)-2-thiazolyl)-4-(((2-hydroxy-1-(hydroxymethyl)ethyl)amino)methyl)-
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Investigative | Compound Info | ||
| Synonyms |
BMS-419437; UNII-09RR39UU4V; BMS-268770; 09RR39UU4V; BMS-387032 analog 2; BDBM5668; CHEMBL300936; SCHEMBL4730772; 2-amino-5-thio-substituted thiazole 45; Q27116143
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
5-(3-Aminopropylamino)-7-(3,5-dimethoxyphenylamino)-1,2,4-triazolo[4,3-c]pyrimidine-8-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL477165; BDBM50263076
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| Activity |
IC50 = 50000 nM
|
[6] | |||
| Compound Name |
1-(3-(8-(Pyridin-4-ylmethylamino)imidazo[1,2-a]pyrazin-6-yl)phenyl)-3-(3-(trifluoromethyl)phenyl)urea
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1081198; SCHEMBL5480112; BDBM50312153
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| Activity |
IC50 = 50000 nM
|
[7] | |||
| Compound Name |
1-[(1-{2-[(3-Chloro-1,2-Dimethyl-1h-Indol-5-Yl)amino]pyrimidin-4-Yl}-3-Methyl-1h-Pyrazol-4-Yl)methyl]azetidin-3-Ol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3622956; SCHEMBL15133954; BDBM138200; US8871778, 141; Q27467492
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|
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| Activity |
IC50 = 53850 nM
|
[8] | |||
| Compound Name |
1,2,4-Oxadiazole Analogue 4i
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL310313; BDBM5063
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| Activity |
IC50 = 55000 nM
|
[9] | |||
| Compound Name |
1,2,4-Oxadiazole Analogue 5c
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM5070; CHEMBL129842
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|
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| Activity |
IC50 = 61000 nM
|
[9] | |||
| Compound Name |
N-(3,4-Dimethoxyphenyl)-6-(morpholin-4-yl)-9H-purin-2-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3115325; BDBM50446908; STK658263; ZINC36358745; AKOS005588997; MCULE-3501033546; N-(3,4-dimethoxyphenyl)-6-morpholino-9H-purin-2-amine
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| Activity |
IC50 = 62000 nM
|
[10] | |||
| Compound Name |
{4-[({[({[(Carbamoylmethyl-ethyl-carbamoyl)-methyl]-ethyl-carbamoyl}-methyl)-isobutyl-carbamoyl]-methyl}-hexanoyl-amino)-methyl]-benzyl}-phosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL130109; BDBM50069343
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| Activity |
IC50 = 63000 nM
|
[11] | |||
| Compound Name |
1,2,4-Oxadiazole Analogue 4b
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM5057; CHEMBL130401
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|
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| Activity |
IC50 = 65000 nM
|
[9] | |||
| Compound Name |
1,2,4-Oxadiazole Analogue 5h
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM5068; CHEMBL133511
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|
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| Activity |
IC50 = 72000 nM
|
[9] | |||
| Compound Name |
(3R)-1-[[1-[2-[(3-Chloro-1,2-dimethylindol-5-yl)amino]pyrimidin-4-yl]-3-methylpyrazol-4-yl]methyl]pyrrolidin-3-ol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3622957; SCHEMBL15134039; BDBM138210; US8871778, 189
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|
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| Activity |
IC50 = 73420 nM
|
[8] | |||
| Compound Name |
9H-Imidazo(4,5-H)isoquinolin-9-one, 2-((2,6-dichlorophenyl)amino)-1,8-dihydro-6,7-dimethyl-
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|
Investigative | Compound Info | ||
| Synonyms |
BIRA-0596; UNII-0U6QL95YQD; 0U6QL95YQD; CHEMBL27085; SCHEMBL676660; SCHEMBL4960262; BDBM50116391; Q27237262; 2-(2,6-dichloroanilino)-6,7-dimethyl-3,8-dihydroimidazo[4,5-h]isoquinolin-9-one
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|
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| Activity |
IC50 = 80000 nM
|
[12] | |||
| Compound Name |
1,2,4-Oxadiazole Analogue 4e
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM5060; CHEMBL423330
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|
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| Activity |
IC50 = 94000 nM
|
[9] | |||
| Compound Name |
1,2,4-Oxadiazole Analogue 5g
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM5067; CHEMBL130106
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|
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| Activity |
IC50 = 96000 nM
|
[9] | |||
| Compound Name |
{4-[({[{[{[Carbamoylmethyl-(3-phenyl-propyl)-carbamoyl]-methyl}-(3-phenyl-propyl)-carbamoyl]-methyl}-(3-phenyl-propyl)-carbamoyl]-methyl}-hexanoyl-amino)-methyl]-benzyl}-phosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL131773; BDBM50069341
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|
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| Activity |
IC50 = 100000 nM
|
[11] | |||
| Compound Name |
{4-[({[[({[Carbamoylmethyl-(3-phenyl-propyl)-carbamoyl]-methyl}-ethyl-carbamoyl)-methyl]-(3-phenyl-propyl)-carbamoyl]-methyl}-hexanoyl-amino)-methyl]-benzyl}-phosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL264257; BDBM50069342
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|
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| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
[4-({[({[[(Carbamoylmethyl-ethyl-carbamoyl)-methyl]-(3-phenyl-propyl)-carbamoyl]-methyl}-ethyl-carbamoyl)-methyl]-hexanoyl-amino}-methyl)-benzyl]-phosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL336975; BDBM50069337
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|
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| Activity |
IC50 = 100000 nM
|
[11] | |||
| Compound Name |
{4-[({[[({[Carbamoylmethyl-(3-phenyl-propyl)-carbamoyl]-methyl}-isobutyl-carbamoyl)-methyl]-(3-phenyl-propyl)-carbamoyl]-methyl}-hexanoyl-amino)-methyl]-benzyl}-phosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL205386; BDBM50069339
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|
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| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
{4-[({[({[(Carbamoylmethyl-isobutyl-carbamoyl)-methyl]-ethyl-carbamoyl}-methyl)-isobutyl-carbamoyl]-methyl}-hexanoyl-amino)-methyl]-benzyl}-phosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL131086; BDBM50069338
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|
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| Activity |
IC50 = 100000 nM
|
[11] | |||
| Compound Name |
1,2,4-Oxadiazole Analogue 7
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM5077; CHEMBL132014
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| Activity |
IC50 = 128000 nM
|
[9] | |||
| Compound Name |
1,2,4-Oxadiazole Analogue 4g
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM5061; CHEMBL341314
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| Activity |
IC50 = 184000 nM
|
[9] | |||
| Compound Name |
N-[(S)-1-[3-(3,4-Dichlorobenzyl)-1,2,4-oxadiazole-5-yl]ethyl]-4-(phosphonooxy)benzenepropanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL419353; BDBM50082329
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| Activity |
IC50 = 198000 nM
|
[13] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 20 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
ISIS-CRP
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|
Phase 1 | Compound Info | ||
| Synonyms |
1-(Tert-butyl)-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; 172889-27-9; pp2; PP 2; 1-(tert-butyl)-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; AG 1879; 1-tert-butyl-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; PP2; 4-Amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine; AG-1879; CHEMBL406845; CHEBI:78331; AK-60369; 1-tert-butyl-3-(4-chlorophenyl)pyrazolo[3,4-d]pyrimidin-4-amine; 3-(4-chlorophenyl) 1-(1,1-dimethylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; C15H16ClN5; 1qpe; 4few; PBBRWFOVCUAONR-UHFFFAOYSA-N; AG1879; PP 2 (AG 1879)
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| Activity |
IC50 > 100000000 nM
|
[14] | |||
| Compound Name |
1,2,4-Oxadiazole Analogue 6
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM5076; CHEMBL131768
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|
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| Activity |
IC50 = 228000 nM
|
[9] | |||
| Compound Name |
(3S)-3-[[(2S)-2-Acetamido-3-(4-phosphonooxyphenyl)propanoyl]amino]-4-[[(2S)-1-[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL336957
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|
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| Activity |
IC50 = 328000 nM
|
[9] | |||
| Compound Name |
(4S)-4-[[(2S)-2-[[(2S)-2-Acetamido-3-(4-phosphonooxyphenyl)propanoyl]amino]-4-amino-4-oxobutanoyl]amino]-5-[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-5-oxopentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL430059
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|
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| Activity |
IC50 = 422000 nM
|
[9] | |||
| Compound Name |
[4-[2-Acetamido-3-[[(1S)-1-[3-carbamoyl-4-(cyclohexylmethoxy)phenyl]ethyl]amino]-3-oxopropyl]phenyl] dihydrogen phosphate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL77638; BDBM50103784
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|
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| Activity |
IC50 = 441000 nM
|
[15] | |||
| Compound Name |
(4-{2-[1-(3-Carbamoyl-4-cyclohexylmethoxy-phenyl)-1-methyl-ethylcarbamoyl]-ethyl}-2-phosphono-phenoxy)-acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL433507; BDBM50103786
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|
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| Activity |
IC50 > 500000 nM
|
[15] | |||
| Compound Name |
[4-[(2S)-2-Acetamido-3-[[(1S)-4-amino-4-oxo-1-[3-[(4,6,6-trimethylcyclohexa-2,4-dien-1-yl)methyl]-1,2,4-oxadiazol-5-yl]butyl]amino]-3-oxopropyl]phenyl] dihydrogen phosphate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL134191
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|
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| Activity |
IC50 > 500000 nM
|
[9] | |||
| Compound Name |
[4-{2-Acetylamino-2-[(S)-1-(3-carbamoyl-4-cyclohexylmethoxy-phenyl)-ethylcarbamoyl]-ethyl}-2-(ethoxy-hydroxy-phosphoryl)-phenoxy]-acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL308734; BDBM50103780
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|
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| Activity |
IC50 > 500000 nM
|
[15] | |||
| Compound Name |
(5-{2-[1-(3-Carbamoyl-4-cyclohexylmethoxy-phenyl)-1-methyl-ethylcarbamoyl]-ethyl}-2-hydroxy-phenyl)-phosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL76937; BDBM50103788
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|
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| Activity |
IC50 > 500000 nM
|
[15] | |||
| Compound Name |
1,2,4-Oxadiazole Analogue 4k
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL76963; BDBM5064
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|
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| Activity |
IC50 > 500000 nM
|
[9] | |||
| Compound Name |
1,2,4-Oxadiazole Analogue 8
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM5078; CHEMBL130751
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|
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| Activity |
IC50 > 500000 nM
|
[9] | |||
| Compound Name |
[5-{2-[1-(3-Carbamoyl-4-cyclohexylmethoxy-phenyl)-1-methyl-ethylcarbamoyl]-ethyl}-2-(tetrazol-1-ylmethoxy)-phenyl]-phosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL311114; BDBM50103778
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|
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| Activity |
IC50 > 500000 nM
|
[15] | |||
| Compound Name |
(4-{2-Acetylamino-2-[1-(3-carbamoyl-4-cyclohexylmethoxy-phenyl)-1-methyl-ethylcarbamoyl]-ethyl}-2-phosphono-phenoxy)-acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL265777; BDBM50103781
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|
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| Activity |
IC50 > 500000 nM
|
[15] | |||
| Compound Name |
{4-[2-Acetylamino-2-(3-carbamoyl-4-cyclohexylmethoxy-benzylcarbamoyl)-ethyl]-2-phosphono-phenoxy}-acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL263721; BDBM50103785
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|
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| Activity |
IC50 > 500000 nM
|
[15] | |||
| Compound Name |
Trifluoro-methanesulfonic acid 4-{2-[1-(3-carbamoyl-4-cyclohexylmethoxy-phenyl)-1-methyl-ethylcarbamoyl]-ethyl}-2-phosphono-phenyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL430825; BDBM50103779
Click to Show/Hide
|
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| Activity |
IC50 > 500000 nM
|
[15] | |||
| Compound Name |
{4-[2-Acetylamino-2-(3-carbamoyl-4-cyclohexylmethoxy-phenylcarbamoyl)-ethyl]-2-phosphono-phenoxy}-acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL308164; BDBM50103783
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|
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| Activity |
IC50 > 500000 nM
|
[15] | |||
| Compound Name |
(4-{2-Acetylamino-2-[(S)-1-(3-carbamoyl-4-cyclohexylmethoxy-phenyl)-ethylcarbamoyl]-ethyl}-2-phosphono-phenoxy)-acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL76350; BDBM50103782
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|
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| Activity |
IC50 > 500000 nM
|
[15] | |||
| Compound Name |
1,2,4-Oxadiazole Analogue 4a
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL77067; BDBM5092
Click to Show/Hide
|
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| Activity |
IC50 > 500000 nM
|
[9] | |||
| Compound Name |
(S)-4-{(S)-2-[(S)-2-Acetylamino-3-(4-phosphonooxy-phenyl)-propionylamino]-4-carboxy-butyrylamino}-4-((1S,2S)-1-carbamoyl-2-methyl-butylcarbamoyl)-butyric acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL311937; Ac-pY-E-E-I-NH2; Ac-pTyr-Glu-Glu-Ile-amide; Ac-pTyr-Glu-Glu-Ile-NH(2); acetyl-Tyr(P)-Glu-Glu-Ile-amide; BDBM50080177
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|
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| Activity |
IC50 = 530000 nM
|
[9] | |||
| Compound Name |
1-[(3-Methyl-1-{2-[(1,2,3-Trimethyl-1h-Indol-5-Yl)amino]pyrimidin-4-Yl}-1h-Pyrazol-4-Yl)methyl]azetidin-3-Ol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3622958; SCHEMBL15310875; BDBM50124868; Q27454824
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|
||||
| Activity |
IC50 = 995800 nM
|
[8] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Discovery of aminothiazole inhibitors of cyclin-dependent kinase 2: synthesis, X-ray crystallographic analysis, and biological activities. J Med Chem. 2002 Aug 29;45(18):3905-27. | ||||
| REF 2 | Discovery and SAR of 2-amino-5-(thioaryl)thiazoles as potent and selective Itk inhibitors. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3706-12. | ||||
| REF 3 | Pyrrolo[2,3-d]pyrimidines containing an extended 5-substituent as potent and selective inhibitors of lck I. Bioorg Med Chem Lett. 2000 Oct 2;10(19):2167-70. | ||||
| REF 4 | The discovery of orally active triaminotriazine aniline amides as inhibitors of p38 MAP kinase. J Med Chem. 2004 Dec 2;47(25):6283-91. | ||||
| REF 5 | Discovery of potential ZAP-70 kinase inhibitors: pharmacophore design, database screening and docking studies. Eur J Med Chem. 2009 Dec;44(12):4793-800. | ||||
| REF 6 | A novel Syk family kinase inhibitor: design, synthesis, and structure-activity relationship of 1,2,4-triazolo[4,3-c]pyrimidine and 1,2,4-triazolo[1,5-c]pyrimidine derivatives. Bioorg Med Chem. 2008 Aug 1;16(15):7347-57. | ||||
| REF 7 | Imidazo[1,2-a]pyrazine diaryl ureas: inhibitors of the receptor tyrosine kinase EphB4. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6991-5. | ||||
| REF 8 | Highly potent and selective pyrazolylpyrimidines as Syk kinase inhibitors. Bioorg Med Chem Lett. 2015 Oct 15;25(20):4441-6. | ||||
| REF 9 | Discovery of potent and selective SH2 inhibitors of the tyrosine kinase ZAP-70. J Med Chem. 1999 Oct 7;42(20):4088-98. | ||||
| REF 10 | Discovery of ZAP70 inhibitors by high-throughput docking into a conformation of its kinase domain generated by molecular dynamics. Bioorg Med Chem Lett. 2013 Oct 15;23(20):5721-6. | ||||
| REF 11 | Solid phase synthesis of a biased mini tetrapeptoid-library for the discovery of monodentate ITAM mimics as ZAP-70 inhibitors. Bioorg Med Chem Lett. 1998 Mar 3;8(5):405-8. | ||||
| REF 12 | Discovery of 2-phenylamino-imidazo[4,5-h]isoquinolin-9-ones: a new class of inhibitors of lck kinase. J Med Chem. 2002 Aug 1;45(16):3394-405. | ||||
| REF 13 | Nonpeptidic SH2 inhibitors of the tyrosine kinase ZAP-70. Bioorg Med Chem Lett. 1999 Oct 18;9(20):3009-14. | ||||
| REF 14 | A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20523-8. | ||||
| REF 15 | A novel phosphotyrosine mimetic 4'-carboxymethyloxy-3'-phosphonophenylalanine (Cpp): exploitation in the design of nonpeptide inhibitors of pp60(Src) SH2 domain. Bioorg Med Chem Lett. 2001 Sep 3;11(17):2319-23. | ||||
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