Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T67754 | Target Info | |||
| Target Name | Transketolase (TK) | ||||
| Synonyms |
TKT1; SDDHD; HEL107; HEL-S-48
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| Target Type | Literature-reported Target | ||||
| Gene Name | TKT | ||||
| Biochemical Class | Transketolase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 2 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-[4-[(4-Aminopyrimidin-5-yl)methyl]-3-methylthiophen-2-yl]ethanol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL257285; BDBM50373881
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| Activity |
EC50 = 52000 nM
|
[1] | |||
| Compound Name |
N-[(2-Amino-6-methylpyridin-3-yl)methyl]-N-[(Z)-2-[[(Z)-1-[(2-amino-6-methylpyridin-3-yl)methyl-formylamino]-4-hydroxybut-1-en-2-yl]disulfanyl]-4-hydroxybut-1-enyl]formamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL252085; SCHEMBL12898324; BDBM50230602
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| Activity |
EC50 = 101870 nM
|
[2] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Non-charged thiamine analogs as inhibitors of enzyme transketolase. Bioorg Med Chem Lett. 2008 Jan 15;18(2):509-12. | ||||
| REF 2 | Prodrug thiamine analogs as inhibitors of the enzyme transketolase. Bioorg Med Chem Lett. 2008 Jan 15;18(2):505-8. | ||||
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