Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T70309 | Target Info | |||
| Target Name | Steroid 5-alpha-reductase 1 (SRD5A1) | ||||
| Synonyms |
SRD5A1; SR type 1; 5-alpha reductase 1
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| Target Type | Clinical trial Target | ||||
| Gene Name | SRD5A1 | ||||
| Biochemical Class | CH-CH donor oxidoreductase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 3 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Finasteride
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Approved | Compound Info | ||
| Synonyms |
Andozac; Eucoprost; FIT; Finasterida; Finasteridum; Finastid; Finpecia; Propecia; Propeshia; Proscar; Prostide; Cahill May Roberts Brand of Finasteride; Chibro Proscar; Frosst Iberica Brand of Finasteride; Lipha Brand of Finasteride; MSD Brand of Finasteride; MSD Chibropharm Brand of Finasteride; MK 0906; MK 906; MK906; Merck Brand 1 of Finasteride; Merck Brand 2 of Finasteride; Merck Frosst Brand 1 of Finasteride; Merck Frosst Brand 2 of Finasteride; Alternova (TN); Appecia (TN); Chibro-Proscar; Finalo (TN); Finara (TN); Finast (TN); Finasterid (TN); Finasterid IVAX (TN); Finasterida [INN-Spanish]; Finasteridum [INN-Latin]; Finax (TN); Fincar (TN); Finpecia (TN); Gefina (TN); KS-1058; MK-0906; MK-906; Merck Sharp & Dhome Brand 2 of Finasteride; Merck Sharp & Dohme Brand 1 of Finasteride; Propecia (TN); Proscar (TN); Prosteride (TN); YM-152; Finasteride (USP/INN); Finasteride [USAN:INN:BAN]; L-652,931; Proscar, Propecia, Finasteride; N-tert-Butyl-3-oxo-4-aza-5alpha-androst-1-en-17beta-carboxamide; N-tert-Butyl-3-oxo-4-aza-5alpha-androst-1-ene-17beta-carboxamide; N-(2-methyl-2-propyl)-3-oxo-4-aza-5alpha-androst-1-ene-17beta-carboxamide; N-(2-Methyl-2-propyl)-3-oxo-4-aza-5-alpha-androst-1-ene-17-beta-carboxamide; (1S,3aS,3bS,5aR,9aR,9bS,11aS)-N-tert-butyl-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,5a,6,9b,10,11-dodecahydroindeno[5,4-f]quinoline-1-carboxamide; (4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-(1,1-dimethylethyl)-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide; (4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-(tert-butyl)-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide; (5alpha,17beta)-(1,1-Dimethylethyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide; 17beta-(N-tert-butylcarbamoyl)-4-aza-5 alpha-androst-1-en-3-one
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| Activity |
IC50 = 53000 nM
|
[1] | |||
| Compound Name |
7-(1,1-Dimethyl-2-propenyloxy)-8-allylcoumarin
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL311013; BDBM50103875; 8-Allyl-7-(1,1-dimethyl-allyloxy)-chromen-2-one
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| Activity |
IC50 = 50300 nM
|
[1] | |||
| Compound Name |
19-Nor-10-aza-5alpha-androstane-3,17-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL14575; BDBM50057289; (5aS,7aS,10aS,10bS,12aS)-7a-Methyl-tetradecahydro-indeno[4,5-c]quinolizine-2,8-dione
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Non Binders of This Target (in total, 3 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
4-(1-Cyclohexylmethyl-1H-indol-5-yl)-benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL41778; BDBM50078264; 4-[1-(Cyclohexylmethyl)-1H-indole-5-yl]benzoic acid
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| Activity |
IC50 = 2100000 nM
|
[3] | |||
| Compound Name |
4-(1-Benzhydryl-1H-indole-5-yl)benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL42258; BDBM50078265; 4-(1-Benzhydryl-1H-indol-5-yl)-benzoic acid
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| Activity |
IC50 = 2780000 nM
|
[3] | |||
| Compound Name |
4-[1-(1-Propylbutyl)-1H-indole-5-yl]benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL288893; BDBM50078266; 4-[1-(1-Propyl-butyl)-1H-indol-5-yl]-benzoic acid
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| Activity |
IC50 = 3200000 nM
|
[3] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | A novel class of inhibitors for steroid 5alpha-reductase: synthesis and evaluation of umbelliferone derivatives. Bioorg Med Chem Lett. 2001 Sep 3;11(17):2361-3. | ||||
| REF 2 | 19-nor-10-azasteroids: a novel class of inhibitors for human steroid 5alpha-reductases 1 and 2. J Med Chem. 1997 Mar 28;40(7):1112-29. | ||||
| REF 3 | N-substituted 4-(5-indolyl)benzoic acids. Synthesis and evaluation of steroid 5alpha-reductase type I and II inhibitory activity. Bioorg Med Chem Lett. 1999 Jun 7;9(11):1601-6. | ||||
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