Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T71081 | Target Info | |||
| Target Name | GTPase HRas (HRAS) | ||||
| Synonyms |
p21ras; cHras; c-H-ras; Transforming protein p21; HaRas; Ha-Ras; H-Ras-1; GTPase HRas, Nterminally processed
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| Target Type | Literature-reported Target | ||||
| Gene Name | HRAS | ||||
| Biochemical Class | Small GTPase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 5 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Tert-butyl-[[(2S,6R)-6-(4-chloro-6-methoxy-3-methylpyrazolo[3,4-b]quinolin-1-yl)-4-(4-nitrophenyl)sulfanylmorpholin-2-yl]methoxy]-dimethylsilane
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL292023; BDBM50287957
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| Activity |
IC50 = 50000 nM
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[1] | |||
| Compound Name |
Benzoic acid (2S,5R)-5-(4-chloro-6-methoxy-3-methyl-pyrazolo[3,4-b]quinolin-1-yl)-2,5-dihydro-furan-2-ylmethyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL302851; BDBM50287950
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| Activity |
IC50 = 80000 nM
|
[1] | |||
| Compound Name |
N-[(3R,4R,5S,6R)-2-[(3,4-Dihydroxyphenyl)methyl-phenylmethoxyamino]-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3218192
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| Activity |
IC50 = 80000 nM
|
[2] | |||
| Compound Name |
(3R,4S,5S,6R)-2-[(3,4-Dihydroxyphenyl)methyl-phenylmethoxyamino]-6-(hydroxymethyl)oxane-3,4,5-triol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3218191
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| Activity |
IC50 = 80000 nM
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[2] | |||
| Compound Name |
(2S,3R,4S,5R,6R)-2-[(2R,3S,4R,5R)-6-[(3,4-Dihydroxyphenyl)methyl-phenylmethoxyamino]-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3218193
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| Activity |
IC50 = 100000 nM
|
[2] | |||
| Non Binders of This Target (in total, 4 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Distamycin A
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Investigative | Compound Info | ||
| Synonyms |
distamycin a; Stallimycin; Distamycin; Herperetin; 636-47-5; DST-A; UNII-80O63P88IS; NSC82150; FI 6426; CHEMBL11252; 80O63P88IS; NCGC00018292-04; NSC 150528; Stallimycinum; Stallimycine; Estalimicina; Stallimicina; Distamicina A; DISTAMYCIN HYDROCHLORIDE; NSC150528; Dst-3; AC1Q5M1Q; AC1L1F7B; DSSTox_RID_81018; DSSTox_CID_25637; DSSTox_GSID_45637; DISTAMYCIN; STALLIMYCIN; SCHEMBL108585; DTXSID9045637; cid_6602691; UPBAOYRENQEPJO-UHFFFAOYSA-N; ZINC3872327; Tox21_110857; 6576-51-8 (mono-hydrochloride); NSC-82150; CCG-36393; BDBM50055659
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| Activity |
IC50 > 200000 nM
|
[3] | |||
| Compound Name |
N-[5-[[5-[(3-Amino-3-iminopropyl)carbamoyl]-1-methylpyrrol-3-yl]carbamoyl]-1-methylpyrrol-3-yl]-4-formamido-1-methylpyrrole-2-carboxamide;methyl 3-[[(6aS)-2-methoxy-11-oxo-6a,7,8,9-tetrahydropyrrolo[2,1-c][1,4]benzodiazepin-3-yl]oxy]propanoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL101290
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| Activity |
IC50 > 200000 nM
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[3] | |||
| Compound Name |
Methyl 3-[[(6aS)-2-methoxy-11-oxo-6a,7,8,9-tetrahydropyrrolo[2,1-c][1,4]benzodiazepin-3-yl]oxy]propanoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL300580; BDBM50072338
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| Activity |
IC50 > 300000 nM
|
[3] | |||
| Compound Name |
4-[(Phenylmethoxyamino)methyl]benzene-1,2-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3218190; AKOS021027570
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| Activity |
IC50 = 320000 nM
|
[2] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Synthesis and evaluation of pyrazolo[3,4-b]quinoline ribofuranosides and their derivatives as inhibitors of oncogenic Ras. Bioorg Med Chem Lett. 1996 Jan 23;6(2):195-200. | ||||
| REF 2 | Binding properties and biological characterization of new sugar-derived Ras ligands. Medchemcomm. 2011;2:396-401. | ||||
| REF 3 | Design, synthesis and biological activity of a pyrrolo [2,1-c][1,4]benzodiazepine (PBD)-distamycin hybrid. Bioorg Med Chem Lett. 1998 Nov 3;8(21):3019-24. | ||||
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