Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T72252 | Target Info | |||
| Target Name | Caspase-7 (CASP7) | ||||
| Synonyms |
MCH3; ICE-like apoptotic protease 3; ICE-LAP3; CMH-1; CASP-7; Apoptotic protease Mch-3
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|
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| Target Type | Clinical trial Target | ||||
| Gene Name | CASP7 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 14 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
1-Butyl-5-[(2S,4R)-2-(methoxymethyl)-4-(trifluoromethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391860; BDBM50435978
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|
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| Activity |
IC50 = 52700 nM
|
[1] | |||
| Compound Name |
1-(4-Fluorobutyl)-5-[(2S,4R)-4-methoxy-2-(methoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391852; BDBM50435986
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| Activity |
IC50 = 59600 nM
|
[1] | |||
| Compound Name |
1-(4-Fluorobutyl)-5-[(2S,4R)-2-(methoxymethyl)-4-(trifluoromethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391861; BDBM50435977
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| Activity |
IC50 = 67700 nM
|
[1] | |||
| Compound Name |
1-Butyl-5-[(2S,4S)-2-(methoxymethyl)-4-(trifluoromethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391863; BDBM50435976
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| Activity |
IC50 = 78300 nM
|
[1] | |||
| Compound Name |
4-(Ethoxycarbonylmethoxy)-1-hydroxy-naphthalene-2-carboxylic Acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL479009; SCHEMBL7824970; ZINC402550; 4-(2-ethoxy-2-oxoethoxy)-1-hydroxynaphthalene-2-carboxylic acid; BDBM50270346; AKOS024325306; MCULE-9442446112; 1-hydroxy-4-ethoxycarbonylmethyloxy-2-naphthoic acid; 4-(2-Ethoxy-2-oxoethoxy)-1-hydroxy-2-naphthoic acid
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| Activity |
IC50 = 84900 nM
|
[2] | |||
| Compound Name |
3,3-Difluoro-5-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl-1-propyl-2H-indole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL522191; BDBM50257479; (S)-3,3-Difluoro-1-propyl-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]indolin-2-one
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(S)-1-[3-(3-Fluoropropoxy)propyl]-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL475858; BDBM50256798
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
3-[3-[5-[(2S)-2-(Methoxymethyl)pyrrolidin-1-yl]sulfonyl-2,3-dioxoindol-1-yl]propoxy]propyl methanesulfonate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL475020; BDBM50256797
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(E,3S)-3-[[(2S,3S)-2-[[(2S)-5-Amino-2-[[(2S)-3-methyl-2-(phenylmethoxycarbonylamino)butanoyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]amino]-5-methylsulfonylpent-4-enoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2324339; BDBM50426562
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|
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
N-(4-Morpholin-4-ylphenyl)-2-(3-oxo-1,2-benzothiazol-2-yl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233645; BDBM50002745
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|
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| Activity |
IC50 = 100400 nM
|
[5] | |||
| Compound Name |
(S)-1-[3-(3-Hydroxypropoxy)propyl]-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL492735; BDBM50257481
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|
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| Activity |
IC50 = 113000 nM
|
[3] | |||
| Compound Name |
1,2-Benzisothiazol-3(2H)-one
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Investigative | Compound Info | ||
| Synonyms |
1,2-Benzisothiazolin-3-one; 1,2-benzothiazol-3-one; benzisothiazolone; Benzo[d]isothiazol-3(2H)-one; benzisothiazolinone; Benzo[d]isothiazol-3-one; Proxel; 1,2-Benzisothiazoline-3-one; Proxel PL; 1,2-BENZISOTHIAZOL-3-ONE; 1,2-benzisothiazolinone; Nipacide BIT; Proxel AB; Benzo[d]isothiazol-3-ol; 2,3-dihydro-1,2-benzothiazol-3-one; Proxel XL 2; benzoisothiazol-3-one; 1,2-benzoisothiazolin-3-one; 1,2-Benzisothiazolone; C7H5NOS; UNII-HRA0F1A4R3; 3-Hydroxy-1,2-benzisothiazole; HRA0F1A4R3; 1,2-Benzoisothiazoline-3-one; 1,2-BENZISOTHAZOL-3(2H)-ONE; 2,3-dihydro-3-oxo-1,2-benzisothiazole; MLS-0254244.0001; Benzo(d)isothiazol-3(2H)-one; Benzisothiazolin-3-one; Caswell No. 079A; Caswell No. 513A; Benzocil; Acticide BIT; Canguard BIT; Denicide BIT; Proxel BD; Proxel CF; Proxel TN; Proxel XL; Proxel BDN; Proxel GXL; Proxel Ultra 5; San-aibac AP; Proxel LV-S; Proxel Press Paste; Apizas AP-DS; Acticide BW 20; Bestcide 200K; Nipacide BIT 20; Parmetol B 70; Parmetol D 11; Proxel GXL(S); Proxel HL 2; Nuosept 485; Nuosept 491; Nuosept 495; Topcide 600; XBINX; CCRIS 6369; Denicide BIT 20N; Koralone B 119; Nipacide BIT 10W; Preventol BIT 20D; Proxel BD 20; Proxel Press Paste D; Troysan 1050; Bioban BIT 20DPG; 1,2-benzisothiazole-3(2h)-one; benzisothiazoline-3-one; Canguard BIT 20DPG; EINECS 220-120-9; SD 202 (bactericide); Canguard Ultra BIT 20LE; EPA Pesticide Chemical Code 098901; 1,2-Benzoisothiazol-3-one; BIT 10W; BIT 20; 2-Thiobenzimide; 2,3-Dihydrobenzisothiazol-3-one; SD 202; 1,2-Benzothiazolinone; PubChem15685; Benzisothiazolone (BIT); ACMC-209u7v; Epitope ID:115004; Benzisothiazol-3(2H)-one; DSSTox_CID_12523; DSSTox_RID_78967; DSSTox_GSID_32523; SCHEMBL26078; cid_17520; KSC201Q7J; MLS000771034; REGID_for_CID_17520; CHEMBL297304; SCHEMBL5586024; DTXSID5032523; BDBM46658; CTK1A1874; HSDB 8271; HMS1755P21; HMS2706H20; KS-00000E5U; ZINC2581983; Tox21_300489; ANW-43433; MFCD00044001; MFCD00127753; AKOS001062434; AKOS030227972; AC-2653; CS-W018117; FS-3163; MCULE-3257757873; NE11261; 1,2-Benzisothiazol-3(2H)-one, 97%; NCGC00164206-01; NCGC00248077-01; NCGC00254467-01; BR-46705; SC-15324; SMR000344133; US9011882, Table 1, Compound 20; AB0008332; DB-027306; AM20060449; B2430; FT-0606282; EN300-17679; 34B335; M-4954; 634B335; A818398; AE-562/40151878; Q411746; 1,2-Benzisothiazol-3(2H)-one, analytical standard; W-107178; Z56983154; F0288-0100
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| Activity |
IC50 = 137400 nM
|
[5] | |||
| Compound Name |
1-(4-Fluorobutyl)-5-[(2S,4S)-2-(methoxymethyl)-4-(trifluoromethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391864; BDBM50435975
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|
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| Activity |
IC50 = 147000 nM
|
[1] | |||
| Compound Name |
2-(2,3-Dihydro-1,4-benzodioxin-2-YL)-1,3-thiazole-4-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
2-(2,3-dihydro-1,4-benzodioxin-3-yl)-1,3-thiazole-4-carboxylic acid; Maybridge3_004185; Oprea1_735244; Burnham Institute Compound 6; BI-9C1; CHEMBL194183; SCHEMBL3875594; BDBM10220; CTK0H3955; DTXSID50384887; HMS1442O05; AKOS014686734; IDI1_015572; FT-0608390; 2-(2,3-Dihydro-benzo[1,4]dioxin-2-yl)-thiazole-4-carboxylic acid; 4-Thiazolecarboxylicacid, 2-(2,3-dihydro-1,4-benzodioxin-2-yl)-
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| Activity |
IC50 = 170000 nM
|
[6] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 37 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-(2,3-Dihydro-1,4-benzodioxin-2-yl)-N-(furan-2-ylmethyl)-1,3-thiazole-4-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
Bio5F2; Maybridge3_004143; Oprea1_701540; Burnham Institute Compound 3; BI-9C8; CHEMBL365119; BDBM10217; HMS1442M07; MCULE-3424746182; IDI1_015530
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|
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| Activity |
IC50 > 200000 nM
|
[6] | |||
| Compound Name |
2-(2,3-Dihydro-1,4-benzodioxin-2-yl)-N,N-dimethyl-1,3-thiazole-4-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
Maybridge3_004099; Oprea1_776634; Burnham Institute Compound 7; BI-9C7; CHEMBL195076; BDBM10221; HMS1442K07; MCULE-2581910611; IDI1_015486
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|
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| Activity |
IC50 > 200000 nM
|
[6] | |||
| Compound Name |
(S)-3-(((9H-Fluoren-9-yl)methoxy)carbonylamino)-5-(phenylsulfonyl)pent-4-enoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242421; BDBM50326100
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|
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| Activity |
IC50 > 200000 nM
|
[7] | |||
| Compound Name |
(S)-3-((2S,3S)-2-(Benzyloxycarbonylamino)-3-methylpentanamido)-5-(methylsulfonyl)pent-4-enoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242700; BDBM50326095
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|
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| Activity |
IC50 > 200000 nM
|
[7] | |||
| Compound Name |
[2-(2,3-Dihydro-1,4-benzodioxin-2-yl)-1,3-thiazol-4-yl](thiophen-2-ylsulfanyl)methanone
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|
Investigative | Compound Info | ||
| Synonyms |
Oprea1_472683; Burnham Institute Compound 5; CHEMBL193538; BDBM10219; BI-9B11; HMS1665H02; MCULE-8815858593; BRD-A61097160-001-01-3
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| Activity |
IC50 > 200000 nM
|
[6] | |||
| Compound Name |
Ethyl 2-(2,3-dihydro-1,4-benzodioxin-2-yl)-4-methyl-1,3-thiazole-5-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
Maybridge3_003925; Oprea1_019141; Burnham Institute Compound 9; BI-9C5; CHEMBL370604; BDBM10223; HMS1442C09; MCULE-8085095066; IDI1_015312
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|
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| Activity |
IC50 > 200000 nM
|
[6] | |||
| Compound Name |
(S)-3-(((9H-Fluoren-9-yl)methoxy)carbonylamino)-5-(methylsulfonyl)pent-4-enoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242422; BDBM50326101
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|
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| Activity |
IC50 > 200000 nM
|
[7] | |||
| Compound Name |
N-(2-Hydroxy-1-methylindol-3-yl)imino-6-(3-methoxyphenyl)-2-methylpyridine-3-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3805517; BDBM50171533
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|
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| Activity |
IC50 > 200000 nM
|
[8] | |||
| Compound Name |
6-(4-Fluorophenyl)-N-(2-hydroxy-1-methylindol-3-yl)imino-2-methylpyridine-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3805744; BDBM50171526
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|
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| Activity |
IC50 > 200000 nM
|
[8] | |||
| Compound Name |
(S)-3-((S)-2-(((9H-Fluoren-9-yl)methoxy)carbonylamino)-3-methylbutanamido)-5-(methylsulfonyl)pent-4-enoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242886; BDBM50326097
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|
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| Activity |
IC50 > 200000 nM
|
[7] | |||
| Compound Name |
6-(3-Chlorophenyl)-N-(2-hydroxy-1-methylindol-3-yl)imino-2-methylpyridine-3-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3805942; BDBM50171506
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|
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| Activity |
IC50 > 200000 nM
|
[8] | |||
| Compound Name |
6-(3,4-Dimethoxyphenyl)-N-(2-hydroxy-1-methylindol-3-yl)imino-2-methylpyridine-3-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3805555; BDBM50171564
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|
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| Activity |
IC50 > 200000 nM
|
[8] | |||
| Compound Name |
N-(2-Hydroxy-1-methylindol-3-yl)imino-6-(2-methoxyphenyl)-2-methylpyridine-3-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3805045; BDBM50171563
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|
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| Activity |
IC50 > 200000 nM
|
[8] | |||
| Compound Name |
Phenyl 2-(2,3-dihydro-1,4-benzodioxin-2-yl)-1,3-thiazole-4-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
Maybridge3_003881; Oprea1_135680; Burnham Institute Compound 4; BI-9C3; CHEMBL195568; SCHEMBL12204572; BDBM10218; HMS1442A09; MCULE-5811988770; IDI1_015268
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|
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| Activity |
IC50 > 200000 nM
|
[6] | |||
| Compound Name |
(4-Chlorophenyl) 2-(2,3-dihydro-1,4-benzodioxin-3-yl)-1,3-thiazole-4-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
Maybridge4_002244; Oprea1_801076; Burnham Institute Compound 8; BI-9C4; CHEMBL195577; BDBM10222; DTXSID40384891; HMS1527F22; CCG-250683; MCULE-9205334627; NCGC00176765-01; BRD-A55814806-001-01-9; 4-chlorophenyl 2-(2,3-dihydro-1,4-benzodioxin-2-yl)-1,3-thiazole-4-carboxylate
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| Activity |
IC50 > 200000 nM
|
[6] | |||
| Compound Name |
(S)-3-((2S,3S)-2-(Benzyloxycarbonylamino)-3-methylpentanamido)-5-(phenylsulfonyl)pent-4-enoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242610; BDBM50326093
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|
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| Activity |
IC50 > 200000 nM
|
[7] | |||
| Compound Name |
[2-(2,3-Dihydro-1,4-benzodioxin-3-yl)-1,3-thiazol-4-yl]-morpholin-4-ylmethanone
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|
Investigative | Compound Info | ||
| Synonyms |
BI-9C2; Oprea1_649863; Burnham Institute Compound 10; CHEMBL194103; SCHEMBL3537780; BDBM10224; 4-{[2-(2,3-dihydro-1,4-benzodioxin-2-yl)-1,3-thiazol-4-yl]carbonyl}morpholine
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| Activity |
IC50 > 200000 nM
|
[6] | |||
| Compound Name |
(S)-3-((S)-2-(((9H-Fluoren-9-yl)methoxy)carbonylamino)-3-methylbutanamido)-5-(phenylsulfonyl)pent-4-enoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242788; BDBM50326096
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|
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| Activity |
IC50 > 200000 nM
|
[7] | |||
| Compound Name |
N-(2-Hydroxy-1-methylindol-3-yl)imino-6-(4-methoxyphenyl)-2-methylpyridine-3-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3805972; BDBM50171532
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|
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| Activity |
IC50 > 200000 nM
|
[8] | |||
| Compound Name |
N-(2-Hydroxy-1-methylindol-3-yl)imino-2-methyl-6-(2-nitrophenyl)pyridine-3-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3805109; BDBM50171503
Click to Show/Hide
|
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| Activity |
IC50 > 200000 nM
|
[8] | |||
| Compound Name |
(S)-3-((S)-2-(Benzyloxycarbonylamino)-3-methylbutanamido)-5-(methylsulfonyl)pent-4-enoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242699; SCHEMBL7884555; BDBM160794; BDBM50326094; US9045524, 61
Click to Show/Hide
|
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| Activity |
IC50 > 200000 nM
|
[7] | |||
| Compound Name |
2-(2,3-Dihydro-1,4-benzodioxin-2-yl)-4-methyl-1,3-thiazole-5-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
Maybridge3_004013; Oprea1_459918; MLS000850593; Burnham Institute Compound 11; BI-9C6; CHEMBL193772; SCHEMBL3880831; BDBM10225; HMS1442G09; HMS2793O03; AKOS014686032; MCULE-3808231625; 2-(2,3-dihydro-1,4-benzodioxin-3-yl)-4-methyl-1,3-thiazole-5-carboxylic acid; IDI1_015400; SMR000456611
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|
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| Activity |
IC50 > 200000 nM
|
[6] | |||
| Compound Name |
N-[(4-Morpholin-4-ylphenyl)methyl]-3-oxo-1,2-benzothiazole-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233639; BDBM50002741
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|
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| Activity |
IC50 = 248000 nM
|
[5] | |||
| Compound Name |
5-[(2S,4S)-4-Methoxy-2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl-1H-indole-2,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391853; BDBM50435985
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|
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| Activity |
IC50 > 500000 nM
|
[1] | |||
| Compound Name |
5-[(2S,5R)-2,5-Bis(methoxymethyl)pyrrolidin-1-yl]sulfonyl-1-(4-fluorobutyl)indole-2,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391978; BDBM50435966
Click to Show/Hide
|
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| Activity |
IC50 > 500000 nM
|
[1] | |||
| Compound Name |
5-[(2R,5S)-2,5-Bis(methoxymethyl)pyrrolidin-1-yl]sulfonyl-1H-indole-2,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391976; BDBM50435968
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|
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| Activity |
IC50 > 500000 nM
|
[1] | |||
| Compound Name |
5-[(2S,5S)-2,5-Bis(methoxymethyl)pyrrolidin-1-yl]sulfonyl-1H-indole-2,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391979; BDBM50435965
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|
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| Activity |
IC50 > 500000 nM
|
[1] | |||
| Compound Name |
5-[(2S,4R)-4-Methoxy-2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl-1H-indole-2,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391850; BDBM50435988
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|
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| Activity |
IC50 > 500000 nM
|
[1] | |||
| Compound Name |
5-[(2S,4R)-2-(Methoxymethyl)-4-(trifluoromethyl)pyrrolidin-1-yl]sulfonyl-1H-indole-2,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391859; BDBM50435979
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|
||||
| Activity |
IC50 > 500000 nM
|
[1] | |||
| Compound Name |
1-Butyl-5-[(2S,4S)-4-methoxy-2-(methoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391854; BDBM50435984
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|
||||
| Activity |
IC50 > 500000 nM
|
[1] | |||
| Compound Name |
7-Chloro-5-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl-1H-indole-2,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3359198; BDBM50031606
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|
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| Activity |
IC50 = 500000 nM
|
[9] | |||
| Compound Name |
5-[(2S,4S)-4-[2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]ethoxy]-2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl-1H-indole-2,3-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391857; BDBM50435981
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| Activity |
IC50 > 500000 nM
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[1] | |||
| Compound Name |
5-[(2R,5S)-2,5-Bis(methoxymethyl)pyrrolidin-1-yl]sulfonyl-1-butylindole-2,3-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391977; BDBM50435967
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| Activity |
IC50 > 500000 nM
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[1] | |||
| Compound Name |
7-Bromo-5-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl-1H-indole-2,3-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3359190; BDBM50031598
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| Activity |
IC50 = 500000 nM
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[9] | |||
| Compound Name |
5-[(2S,4R)-4-[2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]ethoxy]-2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl-1H-indole-2,3-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391856; BDBM50435982
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| Activity |
IC50 > 500000 nM
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[1] | |||
| Compound Name |
1-Butyl-5-[(2S,4S)-4-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]-2-(methoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391858; BDBM50435980
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| Activity |
IC50 > 500000 nM
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[1] | |||
| Compound Name |
7-Iodo-5-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl-1H-indole-2,3-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3359182; BDBM50031590
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| Activity |
IC50 = 500000 nM
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[9] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
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| REF 1 | Influence of 4- or 5-substituents on the pyrrolidine ring of 5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin derivatives on their inhibitory activities towards caspases-3 and -7. Eur J Med Chem. 2013 Jun;64:562-78. | ||||
| REF 2 | Structure-based discovery of a novel non-peptidic small molecular inhibitor of caspase-3. Bioorg Med Chem. 2008 May 1;16(9):4854-9. | ||||
| REF 3 | Fluorinated isatin derivatives. Part 1: synthesis of new N-substituted (S)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatins as potent caspase-3 and -7 inhibitors. Bioorg Med Chem. 2009 Apr 1;17(7):2680-8. | ||||
| REF 4 | Irreversible inhibitors of cysteine proteases. ACS Med Chem Lett. 2013 Jan 28;4(2):163-4. | ||||
| REF 5 | 1,2-benzisothiazol-3-one derivatives as a novel class of small-molecule caspase-3 inhibitors. Bioorg Med Chem. 2014 Apr 15;22(8):2416-26. | ||||
| REF 6 | Discovery of a novel class of reversible non-peptide caspase inhibitors via a structure-based approach. J Med Chem. 2005 Mar 10;48(5):1649-56. | ||||
| REF 7 | Synthesis and evaluation of vinyl sulfones as caspase-3 inhibitors. A structure-activity study. Eur J Med Chem. 2010 Sep;45(9):3858-63. | ||||
| REF 8 | Protective effect of novel substituted nicotine hydrazide analogues against hypoxic brain injury in neonatal rats via inhibition of caspase. Bioorg Med Chem Lett. 2016 Jul 1;26(13):3195-3201. | ||||
| REF 9 | Synthesis of 7-halogenated isatin sulfonamides: nonradioactive counterparts of caspase-3/-7 inhibitor-based potential radiopharmaceuticals for molecular imaging of apoptosis. J Med Chem. 2014 Nov 26;57(22):9383-95. | ||||
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