Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T74937 | Target Info | |||
| Target Name | Dopamine beta hydroxylase (DBH) | ||||
| Synonyms |
Soluble dopamine betahydroxylase; Dopamine betamonooxygenase; Dopamine betahydroxylase; Dopamine beta-monooxygenase; Dopamine beta-hydroxylase
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| Target Type | Clinical trial Target | ||||
| Gene Name | DBH | ||||
| Biochemical Class | Paired donor oxygen oxidoreductase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 22 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
3-(3,4-Dihydroxy-5-nitro-phenyl)-1-(3,4,5-trimethoxy-phenyl)-propenone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL168600; SCHEMBL7288782; BDBM50017845
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| Activity |
IC50 = 50000 nM
|
[1] | |||
| Compound Name |
1-Propanone, 1-(3,4-dihydroxyphenyl)-2-methyl-
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Investigative | Compound Info | ||
| Synonyms |
U-0521; U 0521; 3',4'-Dihydroxy-2-methylpropiophenone; 1-(3,4-dihydroxyphenyl)-2-methylpropan-1-one; MLS000738074; CHEMBL353187; Propiophenone, 3',4'-dihydroxy-2-methyl- (8CI); 3',4'-Dihydroxyisobutyrophenone; NSC 27389; BRN 2093432; 3',4'-Dihydroxy-alpha-methylpropiophenone; ISOBUTYROPHENONE, 3',4'-DIHYDROXY-; Propiophenone, 3',4'-dihydroxy-alpha-methyl-; 1-(3,4-Dihydroxyphenyl)-2-methyl-1-propanone; Isobutyrophenone,4'-dihydroxy-; SCHEMBL8471397; CTK5A2183; DTXSID40203119; HMS2765J17; NSC27389; ZINC1641376; BDBM50017850; NSC-27389; AKOS006241808; Propiophenone,4'-dihydroxy-2-methyl-; 3', 4'-Dihydroxy-2-methylpropiophenone; NCGC00246924-01; SMR000393746; 1-Propanone,4-dihydroxyphenyl)-2-methyl-; Propiophenone,4'-dihydroxy-.alpha.-methyl-; 3',4'-Dihydroxy-.alpha.-methylpropiophenone; C15475; 1-Propanone,1-(3,4-dihydroxyphenyl)-2-methyl-; 1-(3,4-Dihydroxy-phenyl)-2-methyl-propan-1-one; Q27149134; 1-Propanone, 1-(3,4-dihydroxyphenyl)-2-methyl- (9CI)
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| Activity |
IC50 = 50000 nM
|
[1] | |||
| Compound Name |
3-(3,4-Dihydroxy-5-nitro-phenyl)-1-phenyl-propenone
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL169926; BDBM50017857
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| Activity |
IC50 = 50000 nM
|
[1] | |||
| Compound Name |
1-(2,3-Dichlorobenzyl)-1H-imidazole-2(3H)-thione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL294593; SCHEMBL9837948; BDBM50025787; 3-[(2,3-dichlorophenyl)methyl]-1H-imidazole-2-thione; 1-(2,3-Dichloro-benzyl)-1,3-dihydro-imidazole-2-thione
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| Activity |
IC50 = 52480.75 nM
|
[2] | |||
| Compound Name |
1-(4-Nitrobenzyl)-1H-imidazole-2(3H)-thione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL293230; SCHEMBL10425561; BDBM50025807; 3-[(4-nitrophenyl)methyl]-1H-imidazole-2-thione; 1-(4-Nitro-benzyl)-1,3-dihydro-imidazole-2-thione
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| Activity |
IC50 = 52480.75 nM
|
[2] | |||
| Compound Name |
1-(2,3,5,6-Tetrafluoro-4-hydroxybenzyl)-1H-imidazole-2(3H)-thione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL63145; BDBM50025808; 1-(2,3,5,6-Tetrafluoro-4-hydroxy-benzyl)-1,3-dihydro-imidazole-2-thione
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| Activity |
IC50 = 61659.5 nM
|
[2] | |||
| Compound Name |
1-(3-Methyl-4-methoxybenzyl)-1H-imidazole-2(3H)-thione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL63619; BDBM50406071
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| Activity |
IC50 = 69183.1 nM
|
[2] | |||
| Compound Name |
1-(2-Methoxybenzyl)-1H-imidazole-2-thiol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL294549; 1-(2-Methoxybenzyl)-1H-imidazole-2(3H)-thione; SCHEMBL10593660; BDBM50406081; ZINC13776284; AKOS009271083; MCULE-6776603157; L-4833; F2147-0441
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| Activity |
IC50 = 74131.02 nM
|
[2] | |||
| Compound Name |
1-(3-Fluoro-4-methoxybenzyl)-1H-imidazole-2(3H)-thione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL302341; SCHEMBL9621820; BDBM50406074; 1-(3-fluoro4-methoxybenzyl)-2-mercaptoimidazole; 3-[(3-fluoro-4-methoxyphenyl)methyl]-1H-imidazole-2-thione; 1-(4'-methoxy-3'-fluorobenzyl)-1,3-dihydro-2H-imidazole-2-thione
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| Activity |
IC50 = 74131.02 nM
|
[2] | |||
| Compound Name |
1-(2,6-Dichloro-4-hydroxybenzyl)-2-mercaptoimidazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL67018; 1-(2,6-dichloro-4-hydroxybenzyl)imidazole-2-thione; SCHEMBL9836922; BDBM50025805; ZINC13776300; 1-(2,6-Dichloro-4-hydroxybenzyl)-1H-imidazole-2(3H)-thione; 1-(2,6-Dichloro-4-hydroxy-benzyl)-1,3-dihydro-imidazole-2-thione; 3-[(2,6-dichloro-4-hydroxyphenyl)methyl]-1H-imidazole-2-thione
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| Activity |
IC50 = 75857.76 nM
|
[2] | |||
| Compound Name |
1-(3-Bromo-4-methoxybenzyl)-2-mercaptoimidazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL441985; SCHEMBL9621670; BDBM50406079; 1-(3-Bromo-4-methoxybenzyl)-1H-imidazole-2(3H)-thione; 3-[(3-bromo-4-methoxyphenyl)methyl]-1H-imidazole-2-thione
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| Activity |
IC50 = 83176.38 nM
|
[2] | |||
| Compound Name |
1-(4-Chlorobenzyl)-1H-imidazole-2-thiol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL306643; 3-[(4-chlorophenyl)methyl]-1H-imidazole-2-thione; SCHEMBL9838297; BDBM50025788; ZINC13776298; AKOS005208507; MCULE-4570594308; 1-(4-Chlorobenzyl)-4-imidazoline-2-thione; L-4834; 1-(4-Chloro-benzyl)-1,3-dihydro-imidazole-2-thione; F2147-0443
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| Activity |
IC50 = 95499.26 nM
|
[2] | |||
| Compound Name |
1-(2,5-Dichlorobenzyl)-1H-imidazole-2(3H)-thione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL444581; SCHEMBL9836387; BDBM50025801; 3-[(2,5-dichlorophenyl)methyl]-1H-imidazole-2-thione; 1-(2,5-Dichloro-benzyl)-1,3-dihydro-imidazole-2-thione
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| Activity |
IC50 = 97723.72 nM
|
[2] | |||
| Compound Name |
1-(2,4,6-Trichlorobenzyl)-1H-imidazole-2(3H)-thione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL303962; SCHEMBL10337133; BDBM50025796; 3-[(2,4,6-trichlorophenyl)methyl]-1H-imidazole-2-thione; 1-(2,4,6-Trichloro-benzyl)-1,3-dihydro-imidazole-2-thione
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| Activity |
IC50 = 102329.3 nM
|
[2] | |||
| Compound Name |
1-(4-Bromobenzyl)-1H-imidazole-2(3H)-thione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL63701; BDBM50406073; ZINC13776279
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|
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| Activity |
IC50 = 114815.36 nM
|
[2] | |||
| Compound Name |
1-(3-Trifluoromethyl-4-hydroxybenzyl)-2-mercaptoimidazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL292271; SCHEMBL9838413; BDBM50025786; ZINC13776292; 1-(3-Trifluoromethyl-4-hydroxybenzyl)-1H-imidazole-2(3H)-thione; 1-(4-Hydroxy-3-trifluoromethyl-benzyl)-1,3-dihydro-imidazole-2-thione; 3-[[4-hydroxy-3-(trifluoromethyl)phenyl]methyl]-1H-imidazole-2-thione
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|
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| Activity |
IC50 = 120226.44 nM
|
[2] | |||
| Compound Name |
1-(4-Methylbenzyl)-1H-imidazole-2-thiol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL65265; SCHEMBL12305079; BDBM50406072; ZINC13776277; AKOS005208412; MCULE-8251916860; L-4682; 1-(4-Methylbenzyl)-1H-imidazole-2(3H)-thione; F2135-0841
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|
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| Activity |
IC50 = 147910.84 nM
|
[2] | |||
| Compound Name |
1-(3-Hydroxybenzyl)-1H-imidazole-2(3H)-thione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL448479; SCHEMBL10593706; BDBM50025794; 1-(3-Hydroxy-benzyl)-1,3-dihydro-imidazole-2-thione
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|
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| Activity |
IC50 = 147910.84 nM
|
[2] | |||
| Compound Name |
1-(2,6-Dichloro-4-methoxybenzyl)-1H-imidazole-2(3H)-thione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL63667; SCHEMBL9838171; BDBM50406077; 1-[2',6'-dichloro-4'-methoxybenzyl]2-mercaptoimidazole; 3-[(2,6-dichloro-4-methoxyphenyl)methyl]-1H-imidazole-2-thione
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| Activity |
IC50 = 154881.66 nM
|
[2] | |||
| Compound Name |
1-(3-Methoxybenzyl)-1H-imidazole-2(3H)-thione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL68008; SCHEMBL10593221; BDBM50025809; 1-(3-Methoxy-benzyl)-1,3-dihydro-imidazole-2-thione
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| Activity |
IC50 = 158489.32 nM
|
[2] | |||
| Compound Name |
1-(3-Trifluoromethyl-4-methoxybenzyl)-1H-imidazole-2(3H)-thione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL67213; SCHEMBL9837829; BDBM50406084; 1-(3'-trifluoromethyl-4'-methoxy- benzyl)-2-mercaptoimidazole; 3-[[4-methoxy-3-(trifluoromethyl)phenyl]methyl]-1H-imidazole-2-thione
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|
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| Activity |
IC50 = 173780.08 nM
|
[2] | |||
| Compound Name |
2H-Imidazole-2-thione, 1,3-dihydro-1-[[4-(trifluoromethyl)phenyl]methyl]-
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL64938; ACMC-20m8xr; CTK0G4716; DTXSID80561861; BDBM50406075; AKOS012176911; 1-(4-Trifluoromethylbenzyl)-1H-imidazole-2(3H)-thione; 1-{[4-(Trifluoromethyl)phenyl]methyl}-1,3-dihydro-2H-imidazole-2-thione
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| Activity |
IC50 = 199526.23 nM
|
[2] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 9 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
1-(4-Methoxybenzyl)-1H-imidazole-2-thiol
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|
Investigative | Compound Info | ||
| Synonyms |
3-[(4-methoxyphenyl)methyl]-1H-imidazole-2-thione; CHEMBL68010; 1-[(4-methoxyphenyl)methyl]-2,3-dihydro-1H-imidazole-2-thione; 1-(4-Methoxybenzyl)-1H-imidazole-2(3H)-thione; SCHEMBL9622071; BDBM50025486; ZINC13776288; AKOS009271076; AKOS022361559; 1-(4-methoxybenzyl)imidazole-2-thione; MCULE-1922098304; 1-(4-methoxybenzyl)-2-mercaptoimidazole; L-4681; 1-[(4-methoxyphenyl)methyl]-1H-imidazole-2-thiol; 1-(4-Methoxy-benzyl)-1,3-dihydro-imidazole-2-thione; F2135-0843; Z1742055053; 1-(4'-methoxybenzyl)-1,3-dihydro-2H-imidazole-2-thione
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| Activity |
IC50 = 204173.79 nM
|
[2] | |||
| Compound Name |
1-(3,4-Dimethoxybenzyl)-1H-imidazole-2(3H)-thione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL308667; BDBM50406085; AKOS005852370
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| Activity |
IC50 = 338844.16 nM
|
[2] | |||
| Compound Name |
1-(2-Methylbenzyl)-1H-imidazole-2(3H)-thione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL65169; BDBM50406080
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| Activity |
IC50 = 338844.16 nM
|
[2] | |||
| Compound Name |
2H-Imidazole-2-thione, 1,3-dihydro-1-[(4-methoxy-3-nitrophenyl)methyl]-
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL63823; ACMC-20m4wy; SCHEMBL9838126; CTK0G7918; DTXSID50602114; 3-[(4-methoxy-3-nitrophenyl)methyl]-1H-imidazole-2-thione; BDBM50025784; 1-[3'-nitro-4'-methoxybenzyl]-2mercaptoimidazole; 1-(3-Nitro-4-methoxybenzyl)-1H-imidazole-2(3H)-thione; 1-(4-Methoxy-3-nitro-benzyl)-1,3-dihydro-imidazole-2-thione; 1-[(4-Methoxy-3-nitrophenyl)methyl]-1,3-dihydro-2H-imidazole-2-thione
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|
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| Activity |
IC50 = 354813.39 nM
|
[2] | |||
| Compound Name |
1-(2-Chlorobenzyl)-1H-imidazole-2-thiol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL304123; 1-[(2-chlorophenyl)methyl]-2,3-dihydro-1H-imidazole-2-thione; 1-(2-Chlorobenzyl)-1H-imidazole-2(3H)-thione; 3-[(2-chlorophenyl)methyl]-1H-imidazole-2-thione; SCHEMBL9838394; BDBM50406083; ZINC13776266; AKOS005208464; AKOS016371335; MCULE-5374812315; NS-02797; L-4835; F2147-0440
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| Activity |
IC50 = 354813.39 nM
|
[2] | |||
| Compound Name |
1-(2,6-Dimethoxybenzyl)-1H-imidazole-2(3H)-thione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL65391; BDBM50406078
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| Activity |
IC50 = 501187.23 nM
|
[2] | |||
| Compound Name |
1-(2-Hydroxybenzyl)-1H-imidazole-2(3H)-thione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL64641; SCHEMBL10594477; BDBM50025800; ZINC13776286; 1-(2-hydroxybenzyl)imidazole-2-thione; 1-(2-Hydroxy-benzyl)-1,3-dihydro-imidazole-2-thione
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| Activity |
IC50 = 575439.94 nM
|
[2] | |||
| Compound Name |
1-(2,6-Dichlorobenzyl)-1H-imidazole-2(3H)-thione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL292989; SCHEMBL9836934; BDBM50406076; 3-[(2,6-dichlorophenyl)methyl]-1H-imidazole-2-thione
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| Activity |
IC50 = 707945.78 nM
|
[2] | |||
| Compound Name |
1-(2,6-Dimethylbenzyl)-1H-imidazole-2(3H)-thione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL67525; BDBM50406082; ZINC13776260
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| Activity |
IC50 = 1000000 nM
|
[2] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Synthesis of some novel potent and selective catechol O-methyltransferase inhibitors. J Med Chem. 1989 Apr;32(4):841-6. | ||||
| REF 2 | Three-dimensional quantitative structure-activity relationships from molecular similarity matrices and genetic neural networks. 2. Applications. J Med Chem. 1997 Dec 19;40(26):4360-71. | ||||
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