Target Poor or Non Binder(s) Information

Target General Information

Target ID

T75888

Target Info

Target Name

Carnitine O-palmitoyltransferase I (CPT1B)

Synonyms

KIAA1670; Carnitine palmitoyltransferase I-like protein; Carnitine palmitoyltransferase I; Carnitine palmitoyltransferase 1B; Carnitine palmitoyl-transferase I; Carnitine o-palmitoyltransferase-1; Carnitine O-palmitoyltransferase I, muscle isoform; Carnitine O-palmitoyltransferase 1, muscle isoform; CPTI-M; CPTI-L; CPT1-M; CPT-1; CPT I; CPT

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Target Type

Successful Target

Gene Name

CPT1B

Biochemical Class

Acyltransferase

UniProt ID

Q92523

Poor Binders of This Target (in total, 11 binders)

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Compound Name

Amiodarone

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Approved

Compound Info

Synonyms

Amidorone; Aminodarone; Amiobeta; Amiodarex; Amiodarona; Amiodarons; Amiodaronum; Amiohexal; Amjodaronum; Ancar; Aratac;Arycor; Braxan; Corbionax; Cordarex; Cordarone; Kordaron; Labaz; Ortacrone; Pacerone; Rytmarone; Sedacoron; Sedacorone; Tachydaron; ASTA Medica Brand of Amiodarone Hydrochloride; Alphapharm Brand of Amiodarone Hydrochloride; Amiodarone Base; Armstrong Brand of Amiodarone Hydrochloride; Berenguer Infale Brand of Amiodarone Hydrochloride; Betapharm Brand of Amiodarone Hydrochloride; Cordarone Intravenous; G Gam Brand of Amiodarone Hydrochloride; Hexal Brand of Amiodarone Hydrochloride; Leurquin Brand of Amiodarone Hydrochloride; Pharma Investi Brand of Amiodarone Hydrochloride; Sanofi Winthrop Brand of Amiodarone Hydrochloride; Wyeth Brand of Amiodarone Hydrochloride; Ethylaminoethoxy)benzoyl]benzofuran; L 3428; L3428; SKF 33134A; Amio-Aqueous IV; Amiodarona [INN-Spanish]; Amiodaronum [INN-Latin]; Aratac (TN); Arycor (TN); Atlansil (TN); Cordarone (TN); L-3428; Pacerone (TN); Pms-Amiodarone; SKF 33134-A; Amiodarone (USAN/INN); Amiodarone [USAN:BAN:INN]; Ketone, 2-butyl-3-benzofuranyl 4-(2-(diethylamino)ethoxy)-3,5-diiodophenyl; Ketone, 2-butyl-3-benzofuranyl 4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl (7CI,8CI); (2-Butyl-3-benzofuranyl)(4-(2-(diethylamino)ethoxy)-3,5-diidophenyl)methanone; (2-butyl-1-benzofuran-3-yl)(4-{[2-(diethylamino)ethyl]oxy}-3,5-diiodophenyl)methanone; (2-butyl-1-benzofuran-3-yl)-[4-(2-diethylaminoethyloxy)-3,5-diiodophenyl]methanone; (2-butyl-1-benzofuran-3-yl){4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl}methanone; (2-butylbenzofuran-3-yl)-[4-(2-diethylaminoethoxy)-3,5-diiodo-phenyl]-methanone; (2-{4-[(2-butyl-1-benzofuran-3-yl)carbonyl]-2,6-diiodophenoxy}ethyl)diethylamine; 2-Butyl-3-(3,5-diiodo-4-(2-diethylaminoethoxy)benzoyl)benzofuran; 2-Butyl-3-(3,5-diiodo-4-(beta-diethylaminoethoxy)benzoyl)benzofuran; 2-Butyl-3-(4'-beta-N-diethylaminoethoxy-3',5'-diiodobenzoyl)benzofuran; 2-Butyl-3-[3,5-diiodo-4-(2-di; 2-Butyl-3-benzofuranyl 4-(2-(diethylamino)ethoxy)-3,5-diiodophenyl ketone; 2-Butyl-3-benzofuranyl p-((2-diethylamino)ethoxy)-m,m-diiodophenyl ketone; 2-Butyl-3-benzofuranyl p-[(2-diethylamino)ethoxy]-m,m-diiodophenyl ketone; 2-n-Butyl-3',5'-diiodo-4'-N-diethylaminoethoxy-3-benzoylbenzofuran

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Activity

IC50 ~ 100000 nM

[1]

Compound Name

Emeriamine

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Terminated

Compound Info

Synonyms

AD-4808

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Activity

IC50 ~ 100000 nM

[1]

Compound Name

2-[6-(4-Chlorophenoxy)-1,1-difluorohexyl]-2-oxiranecarboxylic acid sodium salt

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Investigative

Compound Info

Synonyms

CHEMBL2216768; SCHEMBL10384995

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Activity

IC50 ~ 50000 nM

[1]

Compound Name

4-Hydroxyphenylglyoxylic acid

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Investigative

Compound Info

Synonyms

Pisolithin A; 2-(4-hydroxyphenyl)-2-oxoacetic acid; (4-hydroxyphenyl)(oxo)acetic acid; 4-Hydroxyphenylglyoxylate; 4-hydroxybenzoylformate; Benzeneacetic acid, 4-hydroxy-alpha-oxo-; CHEMBL129918; Benzeneacetic acid,4-hydroxy-a-oxo-; 2-(4-hydroxyphenyl)-2-oxoacetate; 4-Hydroxyphenylglyoxylicacid; para-Hydroxybenzoylformic acid; p-hydroxybenzoylformic acid; SCHEMBL593133; CTK4C8800; DTXSID40165960; ZINC1529704; (4-Hydroxy-phenyl)-oxo-acetic acid; 4-hydroxy-alpha-oxobenzeneacetic acid; BDBM50118093; MFCD13192798; AKOS022504983; AS-47881; A18241; C03590; AE-562/43460298; Q27103861; Z2510259620

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Activity

IC50 = 60300 nM

[1]

Compound Name

(3R)-3-[4-(3-Hexoxyphenoxy)butylcarbamoylamino]-4-(trimethylazaniumyl)butanoate

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Investigative

Compound Info

Synonyms

CHEMBL2216785; BDBM50403032

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Activity

IC50 = 85300 nM

[1]

Compound Name

(R)-1-{2-[3-(4-Methoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-piperidin-1-yl}-2-phenoxy-ethanone

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Investigative

Compound Info

Synonyms

CHEMBL2216775; SCHEMBL3551374; BDBM50403042; 1-[(2R)-2-[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl]-2-phenoxyethanone

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Activity

IC50 ~ 100000 nM

[1]

Compound Name

4-{[1-(5-Chloro-2-methoxy-benzenesulfonyl)-2,3-dihydro-1H-indole-6-carbonyl]-amino}-benzoic acid

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Investigative

Compound Info

Synonyms

CHEMBL2216779; SCHEMBL3580255; BDBM50403040; 4-[[1-(5-chloro-2-methoxyphenyl)sulfonyl-2,3-dihydroindole-6-carbonyl]amino]benzoic acid

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Activity

IC50 ~ 100000 nM

[1]

Compound Name

Trimetazidine

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Investigative

Compound Info

Synonyms

1-(2,3,4-Trimethoxybenzyl)piperazine; 1-[(2,3,4-trimethoxyphenyl)methyl]piperazine; 1-(2,3,4-Trimethoxy-benzyl)-piperazine; UNII-N9A0A0R9S8; Piperazine, 1-((2,3,4-trimethoxyphenyl)methyl)-; N9A0A0R9S8; Vasartel; Piperazine,1-[(2,3,4-trimethoxyphenyl)methyl]-; Piperazine, 1-[(2,3,4-trimethoxyphenyl)methyl]-; Trimetazidina; Trimetazidinum; MLS001240268; Trimetazidinum [INN-Latin]; Trimetazidina [INN-Spanish]; Trimetazidine [INN:BAN:DCF]; 1,2,3-trimethoxy-4-(piperazinylmethyl)benzene; NCGC00016697-01; SMR000674573; EINECS 225-690-2; Preductal; Vasorel; Preductal MB; Dilatan (TN); Trimetazidine (INN); BAS 06612844; Prestwick0_000549; Prestwick1_000549; Prestwick2_000549; Prestwick3_000549; Oprea1_279550; BSPBio_000597; MLS001331735; SCHEMBL230374; SPBio_002518; BPBio1_000657; CHEMBL203266; DTXSID2048531; BDBM80613; cid_9926449; CTK4J2174; HY-B0968A; HMS2230L07; HMS3374D04; ALBB-004703; BCP16534; BBL013084; MFCD00868263; s5779; SBB007020; STK315643; ZINC19358638; AKOS000308094; 4-(2,3,4-Trimethoxybenzyl)piperazine; DB09069; MCULE-9820869946; 1-(2,3,4-trimethoxy benzyl)piperazine; NCGC00016697-02; SMR000814701; 1-(2,3,4-trimethoxyphenyl)methylpiperazine; 1-(2,3,4-trimethoxyphenylmethyl)piperazine; AB0111344; DB-051731; BB 0220635; CS-0099250; R3927; ST45134749; EN300-14439; 71T250; A25088; D08642; A827982; A837947; Q674703; 1-(2,3,4-trimethoxybenzyl)piperazine;hydrochloride; 1-[2,3,4-trimethoxybenzyl] piperazine dihydrochloride; BRD-K88366685-300-03-7; BRD-K88366685-300-04-5; Z99601262; 1-[(2,3,4-trimethoxyphenyl)methyl]piperazine;hydrochloride

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Activity

IC50 ~ 100000 nM

[1]

Compound Name

Oxfenicine

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Investigative

Compound Info

Synonyms

4-Hydroxy-L-phenylglycine; H-Phg(4-OH)-OH; L-4-Hydroxyphenylglycine; (S)-2-AMINO-2-(4-HYDROXYPHENYL)ACETIC ACID; (S)-Amino-(4-hydroxyphenyl)acetic acid; (2s)-Amino(4-Hydroxyphenyl)Acetic Acid; (2S)-2-amino-2-(4-hydroxyphenyl)acetic acid; UNII-9YH0WH2Z02; L-2-(p-Hydroxyphenyl)glycine; L-2-(4-Hydroxyphenyl)glycine; (2S)-amino(4-hydroxyphenyl)ethanoic acid; Oxfenicine (USAN/INN); L-P-HYDROXYPHENYGLYCINE; 9YH0WH2Z02; UK-25842; UK-25,842; DSSTox_CID_26403; DSSTox_RID_81583; DSSTox_GSID_46403; Oxfenicina; Oxfenicinum; (S)-4-hydroxyphenylglycine; Oxfenicinum [INN-Latin]; p-Hydroxy-L-phenylglycine; Oxfenicina [INN-Spanish]; L-(+)-A-4-HYDROXYPHENYLGLYCINE; Oxfenicine [USAN:INN:BAN]; MFCD00065932; NCGC00164509-01; EINECS 251-061-7; PubChem13975; UK 25842; (S)-alpha-Amino-4-hydroxybenzeneacetic acid; (S)-2-Amino-2-(4-hydroxyphenyl)essigsaeure; bmse000629; SCHEMBL122315; (s)-(4-hydroxyphenyl)glycine; Benzeneacetic acid, alpha-amino-4-hydroxy-, (alphaS)-; CHEMBL1232077; DTXSID3046403; CTK4G8744; KS-00000MKP; 4-Hydroxy-L-(+)-2-phenylglycine; ACT05092; ZINC6667724; Tox21_112144; ANW-48447; BDBM50403035; L-(+)-2-(4-Hydroxyphenyl)glycine; AKOS016842371; Tox21_112144_1; CS-W018812; DB04291; HY-W018026; NCGC00344518-01; AC-24628; BR-28583; DS-11081; SC-20695; W5427; 4-Hydroxy-L-phenylglycine, >=99.0% (NT); C12323; D05292; S-1484; Benzeneacetic acid, a-amino-4-hydroxy-, (aS)-; (2S)-2-azanyl-2-(4-hydroxyphenyl)ethanoic acid; A821286; Benzeneacetic acid, alpha-amino-4-hydroxy-, (S)-; (S)-(+)-2-Amino-2-(4-hydroxyphenyl)acetic Acid; J-018746; Q27095113; UNII-7UYG7X0F53 component LJCWONGJFPCTTL-ZETCQYMHSA-N

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Activity

IC50 ~ 100000 nM

[1]

Compound Name

N-(Thiophen-2-ylmethyl)-1-[[3-(trifluoromethyl)phenyl]methyl]indazole-3-carboxamide

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Investigative

Compound Info

Synonyms

CHEMBL2216776; SCHEMBL958183; BDBM50403041

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Activity

IC50 ~ 100000 nM

[1]

Compound Name

2-Phenoxy-1-[(2R)-2-(4-pyridin-2-yl-1,3-thiazol-2-yl)piperidin-1-yl]ethanone

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Investigative

Compound Info

Synonyms

CHEMBL2216774; SCHEMBL2306797; BDBM50403037

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Activity

IC50 ~ 100000 nM

[1]

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References

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REF 1

Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research. J Med Chem. 2011 May 12;54(9):3109-52.

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