Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T76198 | Target Info | |||
| Target Name | Thromboxane A2 receptor (TBXA2R) | ||||
| Synonyms |
TXA2-R; TXA2 receptor; Prostanoid TP receptor
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|
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| Target Type | Successful Target | ||||
| Gene Name | TBXA2R | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 49 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
OC-000459
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|
Phase 2 | Compound Info | ||
| Synonyms |
OC-1768; OC-2125; OC-2184; OC-459; OC-499; ODC-9101; CRTH2 antagonists (asthma/allergy), Oxagen
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
MK-7246
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|
Phase 1 | Compound Info | ||
| Synonyms |
IDDBCP261213; IDDBCP271467
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-[1-[2-(N-Benzoyl-4-methylanilino)ethyl]piperidin-4-yl]oxyacetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3793911; BDBM50163296
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|
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| Activity |
Ki ~ 50000 nM
|
[2] | |||
| Compound Name |
2-[1-[2-[N-(1,3-Benzodioxole-5-carbonyl)-4-methylanilino]ethyl]piperidin-4-yl]oxyacetic acid;hydrate;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3798917; BDBM50167257
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|
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| Activity |
Ki ~ 50000 nM
|
[3] | |||
| Compound Name |
5-[[(E)-(2-Pyrimidinyl)[3-(trifluoromethyl)phenyl]methylene]aminooxy]valeric acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL130623; DTXSID00878145; BDBM50053780; RIDOGREL,2-PYRIMIDINYL-M-TRIFLUOROMETHYLPHENYL-V; 5-[1-Pyrimidin-2-yl-1-(3-trifluoromethyl-phenyl)-meth-(Z)-ylideneaminooxy]-pentanoic acid
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|
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| Activity |
IC50 = 52000 nM
|
[4] | |||
| Compound Name |
5-[[[(E)-1-Cyclohexyl-2-(1H-imidazol-1-yl)ethylidene]amino]oxy]pentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL439790; SCHEMBL9215084; BDBM50037743; 5-[(E)-(1-cyclohexyl-2-imidazol-1-ylethylidene)amino]oxypentanoic acid; 5-[1-Cyclohexyl-2-imidazol-1-yl-eth-(Z)-ylideneaminooxy]-pentanoic acid
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|
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| Activity |
IC50 = 53100 nM
|
[5] | |||
| Compound Name |
1-[3,4,5-Triiodobenzyl]-1,2,3,4-tetrahydroisoquinoline-6,7-diol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL120278; SCHEMBL5899103; BDBM50470917
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|
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| Activity |
Ki = 60255.96 nM
|
[6] | |||
| Compound Name |
2-[3-[2-[[Benzyl(methoxycarbonyl)amino]methyl]-4-(trifluoromethyl)phenyl]-4-methoxyphenyl]acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1916697; SCHEMBL151705; BDBM50357290
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|
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| Activity |
IC50 = 62400 nM
|
[7] | |||
| Compound Name |
(Z)-7-[3-(Hexylsulfinylmethyl)-7-oxabicyclo[2.2.1]heptan-2-yl]hept-5-enoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL368006
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|
||||
| Activity |
IC50 = 63000 nM
|
[8] | |||
| Compound Name |
CID 44205724
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1916686; SCHEMBL1058254; BDBM50357287
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|
||||
| Activity |
IC50 = 63700 nM
|
[7] | |||
| Compound Name |
2-[3-[2-[[Ethyl(methoxycarbonyl)amino]methyl]-4-(trifluoromethyl)phenyl]-4-methoxyphenyl]acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1916704; SCHEMBL135966; BDBM50357291
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|
||||
| Activity |
IC50 = 67400 nM
|
[7] | |||
| Compound Name |
4-[1-(4-Chloro-benzyl)-1H-benzoimidazol-2-ylsulfanylmethyl]-benzenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL108297; BDBM50147378
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|
||||
| Activity |
Ki ~ 70000 nM
|
[9] | |||
| Compound Name |
2-((R)-8-((R)-2-(4-Fluorophenyl)-N-methylpropanamido)-6,7,8,9-tetrahydropyrido[3,2-b]indolizin-5-yl)acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1641811; SCHEMBL2214672; BDBM50333497
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|
||||
| Activity |
Ki ~ 71000 nM
|
[10] | |||
| Compound Name |
5-[1-(4-Chloro-benzyl)-1H-benzoimidazol-2-ylsulfanylmethyl]-isophthalic acid diethyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL107973; BDBM50147370
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|
||||
| Activity |
Ki ~ 71000 nM
|
[9] | |||
| Compound Name |
5-[[[(Alphae)-alpha-(3-Pyridazinyl)benzylidene]amino]oxy]valeric acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL131088; BDBM50053766; ZINC13759453; 5-[1-Phenyl-1-pyridazin-3-yl-meth-(Z)-ylideneaminooxy]-pentanoic acid
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|
||||
| Activity |
IC50 = 71000 nM
|
[4] | |||
| Compound Name |
(Z)-7-[3-[[2-Oxo-2-(propylamino)ethyl]sulfanylmethyl]-7-oxabicyclo[2.2.1]heptan-2-yl]hept-5-enoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL426586
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|
||||
| Activity |
IC50 = 72000 nM
|
[8] | |||
| Compound Name |
Sodium;2-[2-[3-[(4-chlorophenyl)sulfonylamino]propyl]-2,3-dihydro-1H-inden-5-yl]acetate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL130170
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|
||||
| Activity |
IC50 = 72300 nM
|
[11] | |||
| Compound Name |
1-(4-Chloro-benzyl)-2-(4-trifluoromethyl-benzylsulfanyl)-1H-benzoimidazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL110431; BDBM50147388
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|
||||
| Activity |
Ki ~ 73000 nM
|
[9] | |||
| Compound Name |
1-(4-Chloro-benzyl)-2-(4-methylsulfanyl-benzylsulfanyl)-1H-benzoimidazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL107974; BDBM50147366
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|
||||
| Activity |
Ki ~ 73000 nM
|
[9] | |||
| Compound Name |
5-[[[(Z)-1-Phenyl-2-(1H-imidazol-1-yl)propylidene]amino]oxy]pentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL333868; SCHEMBL7442639; BDBM50037730; 5-[(Z)-(2-imidazol-1-yl-1-phenylpropylidene)amino]oxypentanoic acid; 5-[2-Imidazol-1-yl-1-phenyl-prop-(E)-ylideneaminooxy]-pentanoic acid
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|
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| Activity |
IC50 = 73000 nM
|
[5] | |||
| Compound Name |
1-(4-Chloro-benzyl)-2-[4-(3-methyl-[1,2,4]oxadiazol-5-yl)-benzylsulfanyl]-1H-benzoimidazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL264394; BDBM50147372
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|
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| Activity |
Ki ~ 74000 nM
|
[9] | |||
| Compound Name |
1-(4-Chloro-benzyl)-2-[4-(5-methyl-[1,2,4]oxadiazol-3-yl)-benzylsulfanyl]-1H-benzoimidazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL108856; BDBM50147367
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|
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| Activity |
Ki ~ 74000 nM
|
[9] | |||
| Compound Name |
6-[2-Imidazol-1-yl-1-phenyl-eth-(Z)-ylideneaminooxy]-hexanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL120370; SCHEMBL9209791; BDBM50037727
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|
||||
| Activity |
IC50 = 74500 nM
|
[5] | |||
| Compound Name |
4-{(E)-2-[1-(4-Chloro-benzyl)-1H-benzoimidazol-2-yl]-vinyl}-benzoic acid methyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL111054; BDBM50147371
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|
||||
| Activity |
Ki ~ 75000 nM
|
[9] | |||
| Compound Name |
Sodium;2-[2-[(pentylsulfonylamino)methyl]-2,3-dihydro-1H-inden-5-yl]acetate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL340073
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|
||||
| Activity |
IC50 = 77600 nM
|
[11] | |||
| Compound Name |
(Z)-7-[(1R,2S,3R)-3-(Hexylsulfanylmethyl)-7-oxabicyclo[2.2.1]heptan-2-yl]hept-5-enoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3349042; BDBM50405920
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|
||||
| Activity |
IC50 = 83000 nM
|
[8] | |||
| Compound Name |
1-[3,5-Bis(trifluoromethyl)benzyl]-1,2,3,4-tetrahydroisoquinoline-6,7-diol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL333438; BDBM50470921
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|
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| Activity |
Ki = 83176.38 nM
|
[6] | |||
| Compound Name |
(Z)-7-[3-[[(E)-3-Phenylprop-2-enyl]sulfanylmethyl]-7-oxabicyclo[2.2.1]heptan-2-yl]hept-5-enoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL175178
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|
||||
| Activity |
IC50 = 86000 nM
|
[8] | |||
| Compound Name |
1-(4-Aminobenzyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL173039; SCHEMBL14301922; BDBM50422209
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|
||||
| Activity |
IC50 = 89125.09 nM
|
[12] | |||
| Compound Name |
5-[[(Z)-(2-Pyrimidinyl)[3-(trifluoromethyl)phenyl]methylene]aminooxy]valeric acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL130785; BDBM50053762; 5-[1-Pyrimidin-2-yl-1-(3-trifluoromethyl-phenyl)-meth-(E)-ylideneaminooxy]-pentanoic acid
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|
||||
| Activity |
IC50 = 99000 nM
|
[4] | |||
| Compound Name |
2-[(6R)-6-[(4-Fluorophenyl)sulfonyl-methylamino]-5,6,7,8-tetrahydropyrido[2,3-b]indol-9-yl]acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL552211; BDBM50296985; (R)-2-(6-(4-fluoro-N-methylphenylsulfonamido)-7,8-dihydro-5H-pyrido[2,3-b]indol-9(6H)-yl)acetic acid
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(R)-2-(8-(4-Fluoro-N-methylphenylsulfonamido)-6,7,8,9-tetrahydro-5H-pyrido[3,2-b]indol-5-yl)acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL550465; SCHEMBL2516080; BDBM50296983
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(R)-2-(3-(4-Fluoro-N-methylphenylsulfonamido)-1,2,3,4-tetrahydropyrido[1,2-a]indol-10-yl)acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL564920; SCHEMBL3242718; BDBM50296981
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Sodium;2-[4-[(4-chlorophenyl)sulfonylamino]butyl]-2,3-dihydro-1H-indene-5-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL130045
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|
||||
| Activity |
IC50 = 100000 nM
|
[11] | |||
| Compound Name |
2-[(6R)-6-[(4-Fluorophenyl)sulfonyl-methylamino]-5,6,7,8-tetrahydropyrido[3,4-b]indol-9-yl]acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL550868; BDBM50296984; (R)-2-(6-(4-fluoro-N-methylphenylsulfonamido)-7,8-dihydro-5H-pyrido[3,4-b]indol-9(6H)-yl)acetic acid
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Sodium;2-[2-[(pyridin-3-ylsulfonylamino)methyl]-2,3-dihydro-1H-inden-5-yl]acetate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL134128
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
4-[[[(E)-1-Cyclohexyl-2-(1H-imidazol-1-yl)ethylidene]amino]oxy]butanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL121300; SCHEMBL9208595; BDBM50037733; 4-[(E)-(1-cyclohexyl-2-imidazol-1-ylethylidene)amino]oxybutanoic acid; 4-[1-Cyclohexyl-2-imidazol-1-yl-eth-(Z)-ylideneaminooxy]-butyric acid
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
2-[(3R)-3-[(4-Fluorophenyl)sulfonyl-methylamino]-1,2,3,4,4b,8a-hexahydrocarbazol-9-yl]acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL563664; BDBM50296979; 2-((3R)-3-(4-fluoro-N-methylphenylsulfonamido)-3,4-dihydro-1H-carbazol-9(2H,4bH,8aH)-yl)acetic acid
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Sodium;2-[2-[(benzylsulfonylamino)methyl]-2,3-dihydro-1H-inden-5-yl]acetate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL132573
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
4-[(E)-(2-Imidazol-1-yl-1-phenylethylidene)amino]oxybutanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL120372; SCHEMBL9214210; BDBM50037753; 4-[2-Imidazol-1-yl-1-phenyl-eth-(Z)-ylideneaminooxy]-butyric acid
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
[2'-[(Cyclopropanecarbonyl-ethyl-amino)-methyl]-4'-(6-ethoxy-pyridin-3-yl)-6-methoxy-biphenyl-3-yl]-acetic acid sodium salt
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1668898
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
5-[2-Imidazol-1-yl-1-pyridin-2-yl-eth-(E)-ylideneaminooxy]-pentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL121261; BDBM50037764
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
Sodium;2-[2-[4-[(4-chlorophenyl)sulfonylamino]butyl]-2,3-dihydro-1H-inden-5-yl]acetate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL131336
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
2-[(8R)-8-[(4-Fluorophenyl)sulfonyl-methylamino]-6,7,8,9-tetrahydropyrazino[2,3-b]indol-5-yl]acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL556849; BDBM50296986
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-[(7R)-7-[(4-Fluorophenyl)sulfonyl-methylamino]-6,7,8,9-tetrahydropyrido[2,3-b]indolizin-10-yl]acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL557117; BDBM50296987
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
5-[[[(Alphaz)-alpha-(3-Pyridazinyl)benzylidene]amino]oxy]valeric acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL341211; BDBM50053753; ZINC13759455; 5-[1-Phenyl-1-pyridazin-3-yl-meth-(E)-ylideneaminooxy]-pentanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 104000 nM
|
[4] | |||
| Compound Name |
1-(3,4,5-Trimethoxyanilino)-3,4-dihydroisoquinoline-6,7-diol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL172042; BDBM50422207
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|
||||
| Activity |
Ki = 120226.44 nM
|
[12] | |||
| Compound Name |
Click to Show/Hide
|
Compound Info | |||
| Activity |
IC50 = 62600 nM
|
[1] | |||
| Compound Name |
Click to Show/Hide
|
Compound Info | |||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 8 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(Z)-7-(3-Heptylsulfanyl-7-oxabicyclo[2.2.1]heptan-2-yl)hept-5-enoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL175325
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|
||||
| Activity |
IC50 = 230000 nM
|
[8] | |||
| Compound Name |
5-[[[(E)-1-Phenyl-2-(1H-imidazol-1-yl)propylidene]amino]oxy]pentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL122181; SCHEMBL9218078; BDBM50037755; 5-[(E)-(2-imidazol-1-yl-1-phenylpropylidene)amino]oxypentanoic acid; 5-[2-Imidazol-1-yl-1-phenyl-prop-(Z)-ylideneaminooxy]-pentanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 295000 nM
|
[5] | |||
| Compound Name |
(Z)-7-[3-(Octylsulfanylmethyl)-7-oxabicyclo[2.2.1]heptan-2-yl]hept-5-enoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL176877
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|
||||
| Activity |
IC50 = 547000 nM
|
[8] | |||
| Compound Name |
2-(3-((1-(2,4-Difluorobenzyl)-6-oxo-1,6-dihydropyridazin-3-yl)methyl)-5-fluoro-2-methyl-1H-indol-1-yl)acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2204469; SCHEMBL1757725; BCP18118; BDBM50401097
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|
||||
| Activity |
IC50 = 560000 nM
|
[14] | |||
| Compound Name |
TMQ, 5-TrifluoroMe
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL143645; BDBM82504; PDSP1_000601; PDSP2_000598
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|
||||
| Activity |
IC50 = 1.20E+12 nM
|
[15] | |||
| Compound Name |
TMQ, 5,8-Difluoro
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL358648; BDBM82498; PDSP1_000593; PDSP2_000590
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|
||||
| Activity |
IC50 = 6.31E+12 nM
|
[15] | |||
| Compound Name |
TMQ, 5-Iodo
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL145381; BDBM82488; PDSP1_000594; PDSP2_000591
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|
||||
| Activity |
IC50 = 8.32E+12 nM
|
[15] | |||
| Compound Name |
TMQ, 8-Iodo
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL341654; BDBM82502; PDSP1_000598; PDSP2_000595
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|
||||
| Activity |
IC50 = 3.24E+14 nM
|
[15] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Novel tricyclic antagonists of the prostaglandin D2 receptor DP2 with efficacy in a murine model of allergic rhinitis. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4647-51. | ||||
| REF 2 | Piperidine derivatives as nonprostanoid IP receptor agonists. Bioorg Med Chem Lett. 2016 May 1;26(9):2360-4. | ||||
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