Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T78019 | Target Info | |||
| Target Name | Protein tyrosine phosphatase IVA 3 (PRL-3) | ||||
| Synonyms |
Protein-tyrosine phosphatase of regenerating liver 3; Protein-tyrosine phosphatase 4a3; Protein tyrosine phosphatase type IVA 3; PRL3; PRL-3
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| Target Type | Literature-reported Target | ||||
| Gene Name | PTP4A3 | ||||
| Biochemical Class | Phosphoric monoester hydrolase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 12 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Pentamidine
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Approved | Compound Info | ||
| Synonyms |
Lomidine; Nebupent; PENTAM; PNT; Pentacarinat; Pentamide; Pentamidin; Pentamidina; Pentamidinum; Pneumopent; PENTAMIDINE ISETHIONATE; Pentamidina [DCIT]; Pentamidine isetionate; Pentamidine mesylate; MB 800; Pentam 300; Lomidine (TN); MB-800; Nebupent (as isethionate); Pentacarinat (as isethionate); Pentam 300 (as isethionate); Pentamidine (INN); Pentamidinum [INN-Latin]; RP-2512; Nebupent (*Isethionate); Pentacarinat (*Isethionate); Pentam 300 (*Isethionate); Pentamidine Isethionate 2-Hydroxy-Ethanesulfonic Acid;Pentamidine [INN:BAN:DCF]; RP 2512 (*Isethionate); P,p'-(Pentamethylenedioxy)bis[benzamidine]; P,p'-(Pentamethylenedioxy)dibenzamidine; P,p'-(Pentamethylene-dioxy)bis-benzamidine; Benzenecarboximidamide, 4,4'-(1,5-pentanediylbis(oxy))bis-(9CI); 1,3-BIS(4-AMIDINOPHENOXY)PENTANE; 4, 4'-Diamidinodiphenoxypentane; 4,4'-(1,5-Pentanediylbis(oxy))bis-benzenecarboximidamide; 4,4'-(Pentamethylenedioxy)dibenzamide; 4,4'-(Pentamethylenedioxy)dibenzamidine; 4,4'-Diamidino-.alpha.,.omega.-diphenoxypentane; 4,4'-Diamidinodiphenoxypentane; 4,4'-[pentane-1,5-diylbis(oxy)]dibenzenecarboximidamide; 4-[5-(4-Carbamimidoylphenoxy)pentoxy]benzenecarboximidamide
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| Activity |
IC50 = 53600 nM
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[1] | |||
| Compound Name |
N-{2-[4-(4-Fluorophenyl)piperazin-1-yl]-1-methyl-2-thien-2-ylethyl}-N'-(pyridin-3-ylmethyl)ethanediamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1773181; BDBM50343148; MCULE-8576155103
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
N-(4-Butylphenyl)-2-oxo-1,2-dihydrobenzo[cd]indole-6-sulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1773168; Oprea1_072325; Oprea1_160592; ZINC2184757; BDBM50343142; STL224021; AKOS002276777; MCULE-2878647302; ST45174155; AQ-390/10779040; SR-01000481320; SR-01000481320-1; F0884-0032
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| Activity |
IC50 ~ 50000 nM
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[2] | |||
| Compound Name |
N-(2-Furylmethyl)-N'-{2-[4-(4-methoxyphenyl)piperazin-1-yl]-1-methyl-2-thien-2-ylethyl}ethanediamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1773180; BDBM50343147; MCULE-6096211710
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| Activity |
IC50 ~ 50000 nM
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[2] | |||
| Compound Name |
2-{5-[(E)-(4-Oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl]furan-2-yl}benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CK2/PIM1-IN-1; CHEMBL398538; SCHEMBL3424039; 2-(5-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)furan-2-yl)benzoic acid; ZINC970452; BDBM50237949; STK156908; STL559196; AKOS000323731; HY-135816; CS-0114271; ST51012004; 2-[5-[[(5E)-2-Thioxo-4-oxothiazolidine-5-ylidene]methyl]-2-furyl]benzoic acid; 2-{5-[(4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl]-2-furyl}benzoic acid
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| Activity |
IC50 = 53000 nM
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[3] | |||
| Compound Name |
2-{[5,6-Di(furan-2-yl)-1,2,4-triazin-3-yl]sulfanyl}-N-(2-nitrophenyl)acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2146959; ZINC4110598; BDBM50391712; STK384257; AKOS000578258; MCULE-5041435142; 2-(5,6-Di-furan-2-yl-[1,2,4]triazin-3-ylsulfanyl)-N-(2-nitro-phenyl)-acetamide; EU-0079654
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| Activity |
IC50 = 57000 nM
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[4] | |||
| Compound Name |
Propan-2-yl (E)-3-(3-bromo-4-hydroxy-5-methoxyphenyl)-2-cyanoprop-2-enoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3393149; ZINC5118815; BDBM50059141
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| Activity |
IC50 = 69400 nM
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[3] | |||
| Compound Name |
4-(2-((2,5-Dioxoimidazolidin-4-ylidene)methyl)-1H-pyrrol-1-yl)benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL399586; VC-2959; (E)-4-[2-(2,5-Dioxo-imidazolidin-4-ylidenemethyl)-pyrrol-1-yl]-benzoic acid; BDBM50237957; STK571468; ZINC13749892; AKOS000344815; AKOS005496967; MLS-0390863.0001; SR-01000256261; SR-01000256261-1
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| Activity |
IC50 ~ 100000 nM
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[4] | |||
| Compound Name |
2-[6-(Pyrazin-2-yl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-3-yl]quinoline
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2146956; BDBM50391713; STK637156; ZINC13724453; AKOS005569052; MCULE-9814371674; 6-pyrazin-2-yl-3-quinolin-2-yl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
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| Activity |
IC50 ~ 100000 nM
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[4] | |||
| Compound Name |
8-Carboxy-2-phenyl[1,3]thiazolo[3,2-a]pyridin-4-ium-3-olate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3393147; BDBM50059139; STK922327; AKOS002312449; MCULE-7085291378; ST50758455; VU0608624-1; F3281-0063; 8-carboxy-2-phenylthiazolo[3,2-a]pyridin-4-ium-3-olate; 3-hydroxy-2-phenyl-1,3-thiazolo[3,2-a]pyridine-8-carboxylic acid
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| Activity |
IC50 = 102000 nM
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[3] | |||
| Compound Name |
Ethyl (2E)-2-cyano-3-(3,5-dibromo-4-hydroxyphenyl)prop-2-enoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3393150; BBL019231; BDBM50059142; MFCD06210268; STL199340; ZINC72334076; AKOS017082913; VS-06890
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| Activity |
IC50 = 109200 nM
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[3] | |||
| Compound Name |
Propan-2-yl (2Z)-3-(3-bromo-4-hydroxyphenyl)-2-cyanoprop-2-enoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3393151; BDBM50059143; CAK109693; NCGC00333225-01; AB01328271-02
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| Activity |
IC50 = 167100 nM
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[3] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Discovery of novel PRL-3 inhibitors based on the structure-based virtual screening. Bioorg Med Chem Lett. 2008 Apr 1;18(7):2250-5. | ||||
| REF 2 | Identification and characterization of novel inhibitors of mPTPB, an essential virulent phosphatase from Mycobacterium tuberculosis. ACS Med Chem Lett. 2010 Oct 14;1(7):355-359. | ||||
| REF 3 | Biochemical evaluation of virtual screening methods reveals a cell-active inhibitor of the cancer-promoting phosphatases of regenerating liver. Eur J Med Chem. 2014 Dec 17;88:89-100. | ||||
| REF 4 | Discovery of potent inhibitors of receptor protein tyrosine phosphatase sigma through the structure-based virtual screening. Bioorg Med Chem Lett. 2012 Oct 15;22(20):6333-7. | ||||
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