Target Poor or Non Binder(s) Information
Target General Information | Top | ||||
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Target ID | T78205 | Target Info | |||
Target Name | Long transient receptor potential channel 2 (TRPM2) | ||||
Synonyms |
TrpC7; Transient receptor potential melastatin 2; Transient receptor potential channel 7; Transient receptor potential cation channel subfamily M member 2; LTrpC2; LTrpC-2; Estrogen-responsive element-associated gene 1 protein; EREG1
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Target Type | Literature-reported Target | ||||
Gene Name | TRPM2 | ||||
Biochemical Class | Transient receptor potential catioin channel | ||||
UniProt ID |
Poor Binders of This Target (in total, 10 binders) | Download | Top | |||
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Compound Name |
Adenosine monophosphate
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Approved | Compound Info | ||
Synonyms |
ASMP; Adenovite; Adenyl; Adenylate; Cardiomone; Lycedan; Monophosphadenine; Muskeladenylsaeure; Myoston; PAdo; Phosaden; Phosphaden; Phosphentaside; AMP dianion; Adenine polynucleotides; Adenosine phosphate; Adenosini phosphas; Adenylic acid; Ergadenylic acid; Fosfato de adenosina; Muscle adenylic acid; POLY A; Polyadenylic acids; Vitamin B8; A-5mp; AMP (VAN); AMP (nucleotide); Adenosine Monophosphate (Amp); Adenosine-monophosphate; Adenosine-phosphate; Adenosini phosphas [INN-Latin]; Adenyl (TN); Adenylic acid (VAN); Ado5'P; Fosfato de adenosina [INN-Spanish]; Muskeladenosin-phosphorsaeure; Phosphate d'adenosine; Adenosine 5'-monophosphate; Adenosine 5'-monophosphoric acid; Adenosine 5'-phosphate; Adenosine 5'-phosphoric acid; Adenosine phosphate (USAN/INN); Adenosine phosphate [USAN:BAN:INN]; Adenosine phosphate [USAN:INN:BAN]; Adenosine-5'P; Adenosine-5-monophosphate dianion; Adenosine-5-monophosphoric acid; Adenosine-5-phosphate; Formycin 5'-monophosphate hydrate; Formycin 5'-phosphate; Formycin 5'-phosphate hydrate; Formycin A 5'-monophosphate hydrate; My-B-Den; Phosphate d'adenosine [INN-French]; ADENOSINE-5'-PHOSPHATE; Adenosine 5'-(dihydrogen phosphate); Adenosine, mono(dihydrogen phosphate) (ester); Adenosine-5'-monophosphate; Adenosine-5'-monophosphoric acid; Adenosine-5-monophosphate(2-); GAMMA-ARSONO-BETA, GAMMA-METHYLENEADENOSINE-5'-DIPHOSPHATE; [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate; (S)-1-C-(7-Amino-1H-pyrazolo(4,3-d)pyrimidin-3-yl)-1,4-anhydro-D-ribitol, 5-(dihydrogen phosphate); 1H-Pyrazolo(4,3-d)pyrimidine, 7-amino-3-beta-D-ribofuranosyl-, 5'-(dihydrogen phosphate)-, hydrate; 5'-Adenylic acid, homopolymer; 5'-Deoxy-5'-thioadenosine 5'-monophosphate; 5'-O-phosphonatoadenosine; 5'-O-phosphonoadenosine; 5'-Thio-5'-adenylic acid; 5'-adenosine monophosphate; 5'-adenylic acid; 7-Amino-3-beta-D-ribofuranosyl-1H-pyrazolo(4,3-d)pyrimidine 5'-(dihydrogen phosphate) hydrate; 7A8E6D15-9136-44C1-88C9-E1A224638E56; 7gpb; 8-Aminoadenosine 5'-monophosphate; 8gpb
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Activity |
IC50 = 70000 nM
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[1] | |||
Compound Name |
Flufenamic Acid
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Approved | Compound Info | ||
Synonyms |
flufenamic acid; 530-78-9; Fluphenamic acid; Nichisedan; Achless; Arlef; Tecramine; Paraflu; Lanceat; Flufacid; Plostene; Fullsafe; Parlef; Surika; Parlif; Flufenaminsaeure; Reumajust A; Acido flufenamico; N-(3-Trifluoromethylphenyl)anthranilic acid; Ristogen; Sastridex; Meralen; Ansatin; 2-((3-(Trifluoromethyl)phenyl)amino)benzoic acid; Fluore-200; 2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid; ANT-1; Acide flufenamique; Acidum flufenamicum; TVX 916; INF 1837; 3'-Trifluoromethyldiphenylamine-2-carboxylic acid; NSC-82699; CI 440
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Activity |
IC50 = 70000 nM
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[2] | |||
Compound Name |
Mefenamic acid
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Approved | Compound Info | ||
Synonyms |
ApoMefenamic; Bonabol; Contraflam; Coslan; Dysman; Lysalgo; Mefac; Mefacit; Mefedolo; Mefenacid;Mefenamate; Mefenaminsaeure; Mefic; Mycasaal; Namphen; NuMefenamic; Parkemed; Pinalgesic; Ponalar; Ponalgic; Ponmel; Ponstan; Ponstel; Ponstil; Ponstyl; Ponsyl; Pontal; Rolan; Tanston; Vialidon; APS Brand of Mefenamic Acid; Acide mefenamique; Acide mefenamique [French]; Acido mefenamico; Acidum mefenamicum; Antigen Brand of Mefenamic Acid; Apo Mefenamic; Apotex Brand of Mefenamic Acid; Ashbourne Brand of Mefenamic Acid; Chemidex Brand of Mefenamic Acid; Clonmel Brand of Mefenamic Acid; Elan Brand of Mefenamic Acid; Farmasierra Brand of Mefenamic Acid; First Horizon Brand of Mefenamic Acid; Godecke Brand of Mefenamic Acid; Mefanamic acid; Mefenaminic Acid; Mefenaminsaeure [German]; Mephenamic acid; Mephenaminic acid; Methenamic acid; Nu Mefenamic; Nu Pharm Brand of Mefenamic Acid; PMS Mefenamic Acid; Parke Davis Brand of Mefenamic Acid; Pfizer Brand of Mefenamic Acid; Pharmascience Brand of Mefenamic Acid; Pinewood Brand of Mefenamic Acid; Ponstan forte; Rowa Brand of Mefenamic Acid; Tamany Bonsan; Warner Lambert Brand of Mefenamic Acid; CL 473; CN 35355; HL 1; ID8; INF 3355; M1782; AGN-1255; Ac. mefenamico; Ac. mefenamico [Italian]; Acid, Mefenamic; Acid, Mefenaminic; Acide mefenamique [INN-French]; Acido mefenamico [INN-Spanish]; Acidum mefenamicum [INN-Latin]; Apo-Mefenamic; Bafameritin-M; Bafhameritin-M; CN-35355; Dyfenamic (TN); F0850-6853; Forte, Ponstan; INF-3355; In-M; Mafepain (TN); Meftal (TN); Mephadolor (TN); Nu-Mefenamic; Nu-Pharm Brand of Mefenamic Acid; PMS-Mefenamic Acid; Parkemed (TN); Ponstal (TN); Ponstan (TN); Ponstel (TN); Potarlon (TN); Warner-Lambert Brand of Mefenamic Acid; Mefenamic acid (JP15/USP/INN); Mefenamic acid [USAN:INN:BAN:JAN]; N-2,3-Xylylanthranilic acid; N-(2,3-Dimethylphenyl)anthranilic acid; N-(2,3-Xylyl)anthranilic acid; N-(2,3-Xylyl)-2-aminobenzoic acid; 2-((2,3-Dimethylphenyl)amino)benzoic acid; 2-(2,3-Dimethylanilino)benzoic acid; 2-(2,3-Xylidino)benzoic Acid; 2-(2,3-dimethylphenylamino)benzoic acid; 2-[(2,3-dimethylphenyl)amino]benzoic acid
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Activity |
IC50 = 124000 nM
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[2] | |||
Compound Name |
Niflumic Acid
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Approved | Compound Info | ||
Synonyms |
Actol; Donalgin; Flunir; Forenol; Landruma; NFL; Niflactol; Niflam; Niflugel; Niflumate; Nifluril; Acide niflumique; Acide niflumique [French]; Acido niflumico; Acido niflumico [Italian]; Acidum niflumicum; Nifluminic acid; UPSA Conseil Brand of Niflumic Acid; Upsamedica Brand of Niflumic Acid; N 0630; SC 1332; UP 83; UPSA Brand 1 of Niflumic Acid; UPSA Brand 2 of Niflumic Acid; Acid, Niflumic; Acide niflumique [INN-French]; Acido niflumico [INN-Spanish]; Acidum niflumicum [INN-Latin]; Niflugel (TN); Niflumic acid (INN); Niflumic acid [INN:DCF]; Aza-2 dimethyl-2',3' (tetrazolyl-5)-6 diphenylamino; Aza-2 dimethyl-2',3' (tetrazolyl-5)-6 diphenylamino [French]; 2-(3-(Trifluoromethyl)-phenyl)aminonicotinic acid; 2-(3-(Trifluoromethyl)anilino)nicotinic acid; 2-(3-Trifluoromethyl-phenylamino)-nicotinic acid; 2-(3-Trifluoromethylanilino)nicotinic Acid; 2-(3-[Trifluoromethyl]anilino)nicotinic acid; 2-(A,A,A-Trifluoro-m-toluidino)nicotinic acid; 2-(alpha,alpha,alpha-Trifluoro-m-toluidino)nicotinic acid; 2-[(3-TRIFLUOROMETHYL)PHENYL]AMINO-3-PYRIDINE-CARBOXYLIC ACID; 2-[(3-Trifluoromethyl)phenyl]amino]-3-pyridinecarboxylic Acid; 2-[(3-Trifluoromethylphenyl)amino]nicotinic Acid; 2-[3-(Trifluoromethyl)anilino]nicotinic acid; 2-[3-(trifluoromethyl)anilino]pyridine-3-carboxylic acid; 2-[alpha,alpha,alpha-trifluoro-m-toluidino]-nicotinic acid; 2-{[3-(TRIFLUOROMETHYL)PHENYL]AMINO}NICOTINIC ACID; 2-{[3-(trifluoromethyl)phenyl]amino}pyridine-3-carboxylic acid; 39690A
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Activity |
IC50 = 149000 nM
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[2] | |||
Compound Name |
8-(3-Thiophenyl)adenosine 5'-diphosphoribose
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Investigative | Compound Info | ||
Synonyms |
CHEMBL3110214; BDBM50446560
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Activity |
IC50 = 51000 nM
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[2] | |||
Compound Name |
N-(3-Methylphenyl)anthranilic acid
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Investigative | Compound Info | ||
Synonyms |
2-(m-Tolylamino)benzoic acid; 2-(3-methylanilino)benzoic acid; Anthranilic acid, N-(m-tolyl)-; Benzoic acid, 2-[(3-methylphenyl)amino]-; 2-m-Tolylamino-benzoic acid; CHEMBL23479; Benzoic acid,2-[(3-methylphenyl)amino]-; N-m-Tolylanthranilic acid; N-(3-Tolyl)anthranilic acid; BRN 2214283; N-(m-Methylphenyl)anthranilic acid; N-(3-METHYLPHENYL)ANTHRANILICACID; 3-MFA; Oprea1_239768; 2-(3-toluidino)benzoic acid; SCHEMBL10144302; CTK4D2026; DTXSID00167869; ZINC5420064; BDBM50385713; AKOS011512492; LS10161; NCGC00487314-02; Benzoic acid, 2-((3-methylphenyl)amino)- (9CI)
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Activity |
IC50 = 76000 nM
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[2] | |||
Compound Name |
9-(4-Hydroxybutyl)adenine 5'-diphosphoribose
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Investigative | Compound Info | ||
Synonyms |
CHEMBL3110195; BDBM50446558
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Activity |
IC50 = 100000 nM
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[2] | |||
Compound Name |
Salicyl-AMS
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Investigative | Compound Info | ||
Synonyms |
CHEMBL371502; MMV687700; Salicyl-Adenosine Monosulfamate; SCHEMBL2288469; Salicyl-Adenosine Monosulphamate; salicylic adenosine monosulfamide; BDBM50324670; 5''-O-[N-(salicyl)sulfamoyl]adenosine; 5'-O-[N-(salicyl)sulfamoyl]-adenosine; 5''-O-[N-(salicyl)sulfamoyl] adenosine; 5''-O-[N-(salicyl)-sulfamoyl]-adenosine; 5'-O-(2-Hydroxybenzoylsulfamoyl)adenosine; HY-108941; CS-0032271; 5''-O-(N-(2-hydroxybenzoyl)sulfamoyl)adenosine; adenosine, 5'-O-[[(2-hydroxybenzoyl)amino]sulfonyl]-
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Activity |
IC50 = 100000 nM
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[2] | |||
Compound Name |
ADP-D-ribose
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Investigative | Compound Info | ||
Synonyms |
adpribose; Poly ADP ribose; Adenosine 5'-diphosphoribose; AdoPPRib; Adenosine 5'-(trihydrogen diphosphate), P'-5-ester with D-ribose; ADP-Rib; D-ribofuranose, 5-5'-ester with adenosine 5'-(trihydrogen pyrophosphate); (Rib5)ppA; A5'pp5Rib; POLY ADENOSINE DIPHOSPHATE RIBOSE; Polyadenosine diphosphate ribose; ADP-riboses; CHEMBL2360089; Adenosine 5'-(trihydrogen diphosphate), P'-5-ester with D-ribose, homopolymer; NCGC00163321-01; D-Ribofuranose 5-diphosphoric acid beta-(5'-adenosyl) ester; adenosine 5'-[3-(D-ribofuranos-5-O-yl) dihydrogen diphosphate]
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Activity |
EC50 = 100000 nM
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[2] | |||
Compound Name |
8-(4-(2-Aminopropanoic acid)phenyl)adenosine 5'-monophosphate
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Investigative | Compound Info | ||
Synonyms |
CHEMBL3110204; BDBM50446557
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Activity |
IC50 = 100000 nM
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Click to Show/Hide the Information of All Poor Binders |
Non Binders of This Target (in total, 1 non binders) | Download | Top | |||
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Compound Name |
8-Bromoadenosine 5'-diphosphoribose
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Investigative | Compound Info | ||
Synonyms |
CHEMBL3110216; BDBM50446562
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Activity |
IC50 = 300000 nM
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[2] |
References | Top | ||||
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REF 1 | Design, synthesis and biological activities of 2,3-dihydroquinazolin-4(1H)-one derivatives as TRPM2 inhibitors. Eur J Med Chem. 2018 May 25;152:235-252. | ||||
REF 2 | Structure-activity relationship of adenosine 5'-diphosphoribose at the transient receptor potential melastatin 2 (TRPM2) channel: rational design of antagonists. J Med Chem. 2013 Dec 27;56(24):10079-102. |
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