Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T80276 | Target Info | |||
| Target Name | PI3-kinase alpha (PIK3CA) | ||||
| Synonyms |
p110alpha; Serine/threonine protein kinase PIK3CA; PtdIns3kinase subunit p110alpha; PtdIns3kinase subunit alpha; PtdIns-3-kinase subunit p110-alpha; PtdIns-3-kinase subunit alpha; Phosphoinositide3kinase catalytic alpha polypeptide; Phosphoinositide-3-kinase catalytic alpha polypeptide; Phosphatidylinositol 4,5bisphosphate 3kinase catalytic subunit alpha isoform; Phosphatidylinositol 4,5bisphosphate 3kinase 110 kDa catalytic subunit alpha; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; PI3kinase subunit alpha; PI3Kalpha; PI3K-alpha; PI3-kinase subunit alpha
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| Target Type | Successful Target | ||||
| Gene Name | PIK3CA | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 151 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Sorafenib
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Approved | Compound Info | ||
| Synonyms |
Nexavar; Sorafenibum; Sorafenib [INN]; Nexavar (TN); Sorafenib (INN); N-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-[4-[2-(N-methylcarbamoyl)-4-pyridyloxy]phenyl]urea; N-(4-Chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea; N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcar bamoyl)-4-pyridyloxy)phenyl)urea; 4(4-{3-[4-Chloro-3-(trifluoromethyl)phenyl]ureido}phenoxy)-N(sup 2)-methylpyridine-2-carboxamide; 4-(4-((((4-Chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-2-pyridinecarboxamide; 4-(4-(3-(4-chloro-3-trifluoromethylphenyl)ureido)phenoxy)pyridine-2-carboxyllic acid methyamide-4-methylbenzenesulfonate; 4-(4-{3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido}phenoxy)-N(sup 2)-methylpyridine-2-carboxamide; 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide; 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-pyridine-2-carboxamide; 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide; 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide; 4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE; Sorafenib (Pan-TK inhibitor)
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
(1-(7-Fluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-yl)-6-morpholinoindoline-3,3-diyl)dimethanol
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Approved | Compound Info | ||
| Synonyms |
CHEMBL2171925; SCHEMBL2125478; BDBM50396617
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| Activity |
Ki ~ 125000 nM
|
[2] | |||
| Compound Name |
IC87114
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Investigative | Compound Info | ||
| Synonyms |
IC-87114; 371242-69-2; IC87114; 2-((6-amino-9H-purin-9-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one; IC 87114; UNII-9HC746B1KF; 2-[(6-AMINO-9H-PURIN-9-YL)METHYL]-5-METHYL-3-(2-METHYLPHENYL)-4(3H)-QUINAZOLINONE; 9HC746B1KF; CHEMBL1213082; CHEBI:90686; D-030; 2-[(6-aminopurin-9-yl)methyl]-5-methyl-3-(2-methylphenyl)quinazolin-4-one; 2-[(6-Amino-9h-Purin-9-Yl)methyl]-5-Methyl-3-(2-Methylphenyl)quinazolin-4(3h)-One; BiomolKI2_000002; GNWHRHGTIBRNSM-UHFFFAOYSA-N; PubChem22453; MLS006011148; SCHEMBL360745; GTPL9376; EX-A326
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
8-Phenyl-2-thiomorpholin-4-yl-chromen-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL175944; 8-phenyl-2-thiomorpholin-4-yl-chromen-4-one
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
8-Phenyl-2-piperidin-1-yl-chromen-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL176064; 8-Phenyl-2-piperidin-1-yl-chromen-4-one; SCHEMBL259239
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
2-Morpholin-4-yl-pyrimido[2,1-a]isoquinolin-4-one
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Investigative | Compound Info | ||
| Synonyms |
Compound 401; 168425-64-7; 2-morpholino-4H-pyrimido[2,1-a]isoquinolin-4-one; 2-(morpholin-4-yl)pyrimido[2,1-a]isoquinolin-4-one; CHEMBL179242; 2-(4-MORPHOLINYL)-4H-PYRIMIDO[2,1-A]ISOQUINOLIN-4-ONE; Compound401; 2-Morpholin-4-yl-pyrimido[2,1-a]isoquinolin-4-one; SCHEMBL10092321; KS-00001DEG; CTK4D2994; DTXSID20434626; MolPort-023-276-726; HMS3229D15; EX-A1016; BCP04303; BDBM50159620; ZINC13608047; AKOS016369524; CS-5624; NCGC00378805-02; HY-19341; KB-224235; M2537; B7337; S-7713; J-010456
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
2-[(4-Fluoro-2-methylphenoxy)methyl]-N-(2-hydroxyethyl)-6-morpholin-4-ylpyridine-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL469981
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
6-(2-Morpholin-4-yl-7-pyridin-4-yl-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl)-1H-indazol-3-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2314279; BDBM50425211
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
10-(4-Methoxyphenyl)-2-morpholin-4-ylbenzo[g]chromen-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3915703; BDBM50200519
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| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
4-[(3-Chloro-2-methylphenyl)methyl]-2-(4-morpholinyl)[1,3]thiazolo[4,5-d]pyrimidine-5,7(4H,6H)-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2089115; SCHEMBL726392; BDBM50420319; 4-[(3-chloro-2-methylphenyl)methyl]-2-morpholin-4-yl-[1,3]thiazolo[4,5-d]pyrimidine-5,7-dione
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| Activity |
IC50 = 50000 nM
|
[8] | |||
| Compound Name |
N-Acetyl-N-[5-(4-morpholin-4-ylpyrido[3,2-d]pyrimidin-2-yl)pyrimidin-2-yl]acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109136; BDBM50495508
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| Activity |
IC50 ~ 50000 nM
|
[9] | |||
| Compound Name |
(S)-5,5-Dimethyl-2-(3-phenylmorpholino)-5,6-dihydrobenzo[d]thiazol-7(4H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL469059; BDBM50262359
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| Activity |
IC50 ~ 50000 nM
|
[10] | |||
| Compound Name |
1-Isopropyl-3-(pyrimidin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL3616915; CHEMBL1241391; US9765037, Compound 18; BDBM340891; 1-propan-2-yl-3-pyrimidin-5-ylpyrazolo[3,4-d]pyrimidin-4-amine; 1-isopropyl-3-(pyrimidin-5-yl)-1H-pyrazolo[3,4- d]pyrimidin-4-amine
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| Activity |
IC50 = 50000 nM
|
[1] | |||
| Compound Name |
3-(2-Morpholin-4-yl-7-quinolin-6-yl-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl)phenol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2314581; BDBM50425225
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| Activity |
IC50 ~ 50000 nM
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[6] | |||
| Compound Name |
2-(Benzenesulfonyl)-3-(3,4-dihydro-1H-isoquinolin-2-yl)quinoxaline
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2018687; BDBM50381261
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| Activity |
IC50 ~ 50000 nM
|
[11] | |||
| Compound Name |
2-Methyl-5-(2-morpholin-4-yl-7-pyridin-4-yl-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl)phenol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2314585; SCHEMBL2376432; BDBM50425221
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
3-(2-Morpholin-4-yl-7-pyridin-4-yl-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl)benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2314588; SCHEMBL2378569; BDBM50425218
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
N-Methyl-3-(2-morpholin-4-yl-7-pyridin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)-benzenesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2314275; SCHEMBL2376318; BDBM50425215
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
(R)-5,5-Dimethyl-2-(3-phenylmorpholino)-5,6-dihydrobenzo[d]thiazol-7(4H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL512470; BDBM50262358
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| Activity |
IC50 ~ 50000 nM
|
[10] | |||
| Compound Name |
4-(4-Morpholin-4-ylpyrido[3,2-d]pyrimidin-2-yl)aniline
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109129; BDBM50495502
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| Activity |
IC50 ~ 50000 nM
|
[9] | |||
| Compound Name |
4-[2-(3-Methoxyphenyl)pyrido[3,2-d]pyrimidin-4-yl]morpholine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109124; BDBM50495503
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| Activity |
IC50 ~ 50000 nM
|
[9] | |||
| Compound Name |
4-(3-Phenylsulfanylquinoxalin-2-yl)morpholine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3221626
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| Activity |
IC50 ~ 50000 nM
|
[12] | |||
| Compound Name |
4-[4-(1H-Indazol-4-yl)-7-pyridin-4-yl-5,6-dihydropyrrolo[2,3-d]pyrimidin-2-yl]morpholine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2314280; BDBM50425210
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
4-[4-(1H-Indazol-5-yl)-7-pyridin-4-yl-5,6-dihydropyrrolo[2,3-d]pyrimidin-2-yl]morpholine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2314278; BDBM50425212
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
3-[3-(Dimethylamino)-1-propynyl]-1H-indazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1631893; BDBM50333026; 3-(1H-Indazol-3-yl)-N,N-dimethylprop-2-yn-1-amine
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| Activity |
IC50 ~ 50000 nM
|
[13] | |||
| Compound Name |
2-Methyl-3-(2-morpholin-4-yl-7-pyridin-4-yl-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl)phenol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2314586; SCHEMBL2378463; BDBM50425220
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| Activity |
IC50 ~ 50000 nM
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[6] | |||
| Compound Name |
3-[4-(4,4-Difluoropiperidin-1-yl)pyrido[3,2-d]pyrimidin-2-yl]phenol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109120; BDBM50495511
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| Activity |
IC50 ~ 50000 nM
|
[9] | |||
| Compound Name |
3-[4-(4-Methylpiperazin-1-yl)pyrido[3,2-d]pyrimidin-2-yl]phenol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109119; BDBM50495515
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| Activity |
IC50 ~ 50000 nM
|
[9] | |||
| Compound Name |
N-[3-(2-Pyridin-4-ylpyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-3-(trifluoromethyl)benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1089082; SCHEMBL4656083; BDBM50314051; N-(3-(2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide
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| Activity |
IC50 ~ 50000 nM
|
[14] | |||
| Compound Name |
3-[4-(1,1-Dioxo-1,4-thiazinan-4-yl)pyrido[3,2-d]pyrimidin-2-yl]phenol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109118; BDBM50495513
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| Activity |
IC50 ~ 50000 nM
|
[9] | |||
| Compound Name |
4-[4-(1H-Indazol-7-yl)-7-pyridin-4-yl-5,6-dihydropyrrolo[2,3-d]pyrimidin-2-yl]morpholine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2314281; BDBM50425209
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| Activity |
IC50 ~ 50000 nM
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[6] | |||
| Compound Name |
4-[4-(1H-Indazol-6-yl)-7-pyridin-4-yl-5,6-dihydropyrrolo[2,3-d]pyrimidin-2-yl]morpholine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2314277; BDBM50425213
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| Activity |
IC50 ~ 50000 nM
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[6] | |||
| Compound Name |
3-(2-Morpholin-4-yl-7-pyridin-2-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)-phenol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2314577; SCHEMBL2376578; BDBM50425229; 3-(2-morpholin-4-yl-7-pyridin-2-yl-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl)phenol
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| Activity |
IC50 ~ 50000 nM
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[6] | |||
| Compound Name |
3-(2-Acetamido-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-methylbenzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064486; SCHEMBL3101636; BDBM50389398
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| Activity |
IC50 ~ 50118.72 nM
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[15] | |||
| Compound Name |
N-[6-(3-Methylsulfonylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064483; SCHEMBL3105036; BDBM50389396
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| Activity |
IC50 ~ 50118.72 nM
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[15] | |||
| Compound Name |
Ethyl 2-morpholinoisonicotinate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL450243; 2-(4-morpholinyl)-4-Pyridinecarboxylic acid ethyl ester; Ethyl 2-morpholin-4-ylpyridine-4-carboxylate; Ethyl 2-morpholinopyridine-4-carboxylate; DTXSID20376597; BDBM50278660; MFCD04114261; ZINC33369609; AS-31386; DB-077243; FT-0747321; 2-morpholin-4-ylisonicotinic acid ethyl ester; 2-morpholin-4-yl-isonicotinic acid ethyl ester; A-2241; 2-(4-morpholinyl)pyridine-4-carboxylic acid ethyl ester
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| Activity |
IC50 = 51000 nM
|
[5] | |||
| Compound Name |
6-[3-Hydroxypropyl(naphthalen-1-ylmethyl)amino]-4-morpholin-4-yl-1H-pyrimidin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2165181; BDBM50395812
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| Activity |
IC50 = 51500 nM
|
[16] | |||
| Compound Name |
4-Morpholin-4-yl-6-[[(1S)-1-naphthalen-1-ylethyl]amino]-1H-pyrimidin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2158444; BDBM50393982
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| Activity |
IC50 = 52800 nM
|
[17] | |||
| Compound Name |
N-(4-Benzoylphenyl)-1h-indole-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3799345; BDBM50165850
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| Activity |
IC50 = 54000 nM
|
[18] | |||
| Compound Name |
N-[3-Benzoylphenyl]-1h-indole-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3799956; BDBM50165849; AKOS007667379
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| Activity |
IC50 = 55000 nM
|
[18] | |||
| Compound Name |
4-Morpholin-4-yl-6-[naphthalen-1-ylmethyl-(3,3,3-trifluoro-2-hydroxypropyl)amino]-1H-pyrimidin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2165185; BDBM50395808
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| Activity |
IC50 = 56900 nM
|
[16] | |||
| Compound Name |
Chembl4292760
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Investigative | Compound Info | ||
| Synonyms |
BDBM50467454
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| Activity |
EC50 = 58400 nM
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[19] | |||
| Compound Name |
5-(Pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1645094; 1H-Pyrrolo[2,3-b]pyridine, 5-(4-pyridinyl)-; 5-Pyridin-4-yl-1H-pyrrolo[2,3-b]pyridine; SCHEMBL416750; CTK3C9693; DTXSID10693427; BDBM50333210; ZINC66259733; 5-(4-Pyridinyl)-1H-pyrrolo[2,3-b]pyridine
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| Activity |
IC50 = 59000 nM
|
[20] | |||
| Compound Name |
6-Methyl-8-(2-methylphenoxy)-2-morpholin-4-yl-1H-quinolin-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3218572
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| Activity |
IC50 = 61000 nM
|
[3] | |||
| Compound Name |
N-(4-Acetylphenyl)-1H-indole-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3797839; SCHEMBL15478841; BDBM50165848; AKOS008916268
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| Activity |
IC50 = 61000 nM
|
[18] | |||
| Compound Name |
2-(Naphthalen-1-ylmethylamino)-4-(1H-pyrazol-4-yl)-1H-pyrimidin-6-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2165176; BDBM50395817
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| Activity |
IC50 = 62300 nM
|
[16] | |||
| Compound Name |
N-[6-(1-Methylpyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064497; BDBM50389425
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| Activity |
IC50 ~ 63095.73 nM
|
[15] | |||
| Compound Name |
6-[6-(Methylaminomethyl)pyridin-3-yl]-1,3-benzothiazol-2-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3600686; BDBM50107262
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| Activity |
IC50 = 63095.73 nM
|
[21] | |||
| Compound Name |
N-(3-Acetylphenyl)-1H-indole-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3800262; ZINC8076710; BDBM50165847; AKOS008920869; MCULE-5855200375; Z30815669
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| Activity |
IC50 = 64000 nM
|
[18] | |||
| Compound Name |
2-(4-Chlorophenyl)-1-(2,3,4-trihydroxyphenyl)ethanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1093382; ZINC5569646; BDBM50467456; STK962731; AKOS024365999; MCULE-4754882578; ST50999309; 2',3',4'-Trihydroxy-alpha-(4-chlorophenyl)acetophenone; 2-(4-chlorophenyl)-1-(2,3,4-trihydroxyphenyl)ethan-1-one
Click to Show/Hide
|
||||
| Activity |
EC50 = 69300 nM
|
[19] | |||
| Compound Name |
6-[4-Hydroxybutyl(naphthalen-1-ylmethyl)amino]-4-morpholin-4-yl-1H-pyrimidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2165182; BDBM50395811
Click to Show/Hide
|
||||
| Activity |
IC50 = 73700 nM
|
[16] | |||
| Compound Name |
6-[Cyclopropyl(naphthalen-1-ylmethyl)amino]-4-morpholin-4-yl-1H-pyrimidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2165179; BDBM50395814
Click to Show/Hide
|
||||
| Activity |
IC50 = 76000 nM
|
[16] | |||
| Compound Name |
2-(4-Chlorophenyl)-1-(2,4,6-trihydroxyphenyl)ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1552100; Q63398682; 2-(4-chlorophenyl)-1-(2,4,6-trihydroxyphenyl)ethan-1-one; 2,4,5-Trihydroxyphenyl-p-chlorobenzylketone; Oprea1_124623; CTK4C8429; ZINC58162; DTXSID90343857; BDBM50467457; MFCD00498164; AKOS002384968; MCULE-6656713419; NCGC00142551-01; ST057629; O-BENZOTRIAZOL-1-YL-NNNN-BIS(PENTA&; 2,4-Dihydroxy-6-hydroxy-4'-chlorodeoxybenzoin; 2-(4-chlorophenyl)-1-(2,4,6-trihydroxyphenyl)-ethanone; 2-(4-Chlorophenyl)-1-(2,4,6-trihydroxyphenyl)ethanone #; Ethanone,2-(4-chlorophenyl)-1-(2,4,6-trihydroxyphenyl)-
Click to Show/Hide
|
||||
| Activity |
EC50 = 79300 nM
|
[19] | |||
| Compound Name |
1-(Cyclopropylmethyl)-4-[2-[(1,1-dioxothian-4-yl)methylamino]-1,3-benzothiazol-6-yl]pyridin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3600784; BDBM50107256
Click to Show/Hide
|
||||
| Activity |
IC50 = 79432.82 nM
|
[21] | |||
| Compound Name |
N-[6-(3-Methoxyphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064480; SCHEMBL3098972; BDBM50389393
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 79432.82 nM
|
[15] | |||
| Compound Name |
4-(3-Methoxyazetidin-1-yl)-2-(naphthalen-1-ylmethylamino)-1H-pyrimidin-6-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2165193; BDBM50395819
Click to Show/Hide
|
||||
| Activity |
IC50 = 82600 nM
|
[16] | |||
| Compound Name |
6-[Ethyl(naphthalen-1-ylmethyl)amino]-4-morpholin-4-yl-1H-pyrimidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2165178; BDBM50395815
Click to Show/Hide
|
||||
| Activity |
IC50 = 82800 nM
|
[16] | |||
| Compound Name |
2-(Pyridin-4-yl)benzo[d]oxazol-5-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1645096; BDBM50333212; ZINC16431343; AKOS003232867; 2-(PYRIDIN-4-YL)-1,3-BENZOXAZOL-5-OL
Click to Show/Hide
|
||||
| Activity |
IC50 = 83000 nM
|
[20] | |||
| Compound Name |
4-N-Benzyl-6-morpholin-4-ylpyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2158430; BDBM50393992; SR-01000648934; SR-01000648934-1
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 83300 nM
|
[17] | |||
| Compound Name |
6-(Benzylamino)-4-morpholin-4-yl-1H-pyrimidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2158424; BDBM50393979
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 83300 nM
|
[17] | |||
| Compound Name |
2-Pyridin-4-yl-benzooxazol-5-ylamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-(pyridin-4-yl)-1,3-benzoxazol-5-amine; 2-(pyridin-4-yl)benzo[d]oxazol-5-amine; 2-pyridin-4-yl-1,3-benzoxazol-5-amine; CHEMBL1645099; 2-(4-pyridyl)benzoxazole-5-ylamine; Oprea1_262137; CBDivE_012963; SCHEMBL4076162; CTK4H3354; DTXSID90352904; ZINC155043; ALBB-006224; 2-(4-Pyridinyl)-5-benzoxazolamine; 1121AE; BBL012052; BDBM50333214; MFCD00448006; SBB007305; STK026134; 2-Pyridin-4-ylbenzooxazol-5-yl amine; AKOS000108388; CCG-109259; MCULE-8999136327; VS-03182; 5-amino-2-(pyridine-4-yl)benzo[d]oxazole; 5-amino-2-(pyridine-4-yl) benzo[d]oxazole; BB 0245215; EU-0041953; H2652; ST50024827; SR-01000465976; SR-01000465976-1
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 83300 nM
|
[20] | |||
| Compound Name |
6-[3-(Dimethylamino)propyl-(naphthalen-1-ylmethyl)amino]-4-morpholin-4-yl-1H-pyrimidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2165188; BDBM50395805
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 83300 nM
|
[16] | |||
| Compound Name |
5-(Pyridin-4-yl)-[1,2,4]triazolo[1,5-a]pyrimidin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1645098; BDBM50333213
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 83300 nM
|
[20] | |||
| Compound Name |
2-(Aminomethyl)-N-benzyl-6-morpholin-4-ylpyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2158432; BDBM50393991
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 83300 nM
|
[17] | |||
| Compound Name |
4-Morpholin-4-yl-6-(naphthalen-1-ylmethylamino)-1H-pyrimidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2158442; BDBM50393983
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 83300 nM
|
[17] | |||
| Compound Name |
6-[2-(Dimethylamino)ethyl-(naphthalen-1-ylmethyl)amino]-4-morpholin-4-yl-1H-pyrimidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2165187; BDBM50395806
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 83300 nM
|
[16] | |||
| Compound Name |
N-Benzyl-6-morpholinopyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2158433; SCHEMBL5029684; BDBM50393990; N-Benzyl-6-morpholinopyrimidine-4-amine; N-benzyl-6-morpholin-4-ylpyrimidin-4-amine; SR-01000650518; SR-01000650518-1; F6570-1546
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 83300 nM
|
[17] | |||
| Compound Name |
2-{[4-Amino-3-(3-Hydroxyprop-1-Yn-1-Yl)-1h-Pyrazolo[3,4-D]pyrimidin-1-Yl]methyl}-5-Methyl-3-(2-Methylphenyl)quinazolin-4(3h)-One
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1213116; SCHEMBL7911679; BDBM50323730; Q27465226
Click to Show/Hide
|
||||
| Activity |
IC50 = 85000 nM
|
[22] | |||
| Compound Name |
4-[6-(2-Pyrazin-2-ylethylsulfonylmethyl)-2-pyridin-2-ylpyrimidin-4-yl]morpholine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2030437; SCHEMBL1271852; BDBM50384259; ZINC84670314
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 90000 nM
|
[23] | |||
| Compound Name |
Chembl4295122
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL10563951; BDBM50467455; 2',3',4'-Trihydroxy-alpha-(3-chlorophenyl)acetophenone
Click to Show/Hide
|
||||
| Activity |
EC50 = 98200 nM
|
[19] | |||
| Compound Name |
2-((4-Fluoro-2-methylphenylamino)methyl)-6-morpholinoisonicotinaldehyde
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL512311; BDBM50278544
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[5] | |||
| Compound Name |
8-Chloro-6-(5-methylsulfonylpyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064569; BDBM50389429
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
N-(6-Isoquinolin-4-yl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064494; SCHEMBL3104880; BDBM50389404
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
2-((4-Fluoro-2-methylphenylamino)methyl)-6-(3-hydroxypyrrolidin-1-yl)isonicotinic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL471046; BDBM50278576
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
N,N-Dimethyl-6-(5-methylsulfonylpyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064505; SCHEMBL3091951; BDBM50389388
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
3-(Phenylethynyl)-1H-indazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1631889; SCHEMBL7982776; 3-(2-phenylethynyl)-2H-indazole; BDBM50333030
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
3-(4-Nitrophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL1320032; CHEMBL1241358; 3-(4-nitrophenyl)-2H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
1-Tert-Butyl-3-Naphthalen-2-Yl-1h-Pyrazolo[3,4-D]pyrimidin-4-Amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1231371; 1-tert-butyl-3-(naphthalen-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; NA-PP2; SCHEMBL1964558; 1-tert-butyl-3-naphthalen-2-ylpyrazolo[3,4-d]pyrimidin-4-amine; BDBM50345704; NCGC00167637-01; Q27458432; 1-tert-butyl-3-(2-naphthyl)pyrazolo[3,4-d]pyrimidin-4-amine; 4-Amino-1-tert-butyl-3-(2-naphthyl)pyrazolo[3,4-d]pyrimidine; 1-(tert-butyl)-3-(naphthalen-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (3)
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
N-Ethyl-N-[(3-phenylpyrido[2,3-b]pyrazin-6-yl)carbamoyl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL5447732; CHEMBL3695619; BDBM142657; US8937068, 46
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[24] | |||
| Compound Name |
3-(2-Ethoxynaphthalen-6-yl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242661; SCHEMBL12608279
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
3-((3,5-Bis(trifluoromethyl)phenyl)ethynyl)-1Hindazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1631899; SCHEMBL12269739; BDBM50333020
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
1-Benzyl-3-(naphthalen-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1241585; 1-benzyl-3-naphthalen-2-ylpyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
2-(4-Amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-(4-Amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-phenol; CHEMBL1241355; J-002258; (6Z)-6-(4-amino-1,2-dihydropyrazolo[3,4-d]pyrimidin-3-ylidene)cyclohexa-2,4-dien-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
N-[4-(4-Amino-2H-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl]-4-phenylbenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242116
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
N-[6-[3-(Benzylsulfamoyl)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-yl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064490; BDBM50389401
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
3-((3,5-Difluorophenyl)ethynyl)-1H-indazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1631890; SCHEMBL12269817; BDBM50333029
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
4-((1H-Indazol-3-yl)ethynyl)benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1631901; SCHEMBL12269664; BDBM50333018; ZINC66251573
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
N-[6-[4-(Methylsulfamoyl)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-yl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064488; BDBM50389423
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
N-[6-[3-(Methanesulfonamido)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclohexanecarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064502; SCHEMBL14259157; BDBM50389409
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
N-[4-(Methylsulfonylmethyl)-6-morpholin-4-ylpyrimidin-2-yl]-1,2-oxazole-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2030450; BDBM50384249
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
2-(Bis(2-hydroxyethyl)amino)-6-((4-fluoro-2-methylphenylamino)methyl)isonicotinic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL469807; BDBM50278579
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
1-Isopropyl-3-(3,4,5-trimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242660; SCHEMBL3602391; BDBM50345734; 1-propan-2-yl-3-(3,4,5-trimethoxyphenyl)pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
2-((4-Fluoro-2-methylphenylamino)methyl)-6-(piperazin-1-yl)isonicotinic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL469797; BDBM50278546
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
5-(2-Amino-7-fluoro-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-tert-butylpyridine-3-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064572; BDBM50389421
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
2-((4-Fluoro-2-methylphenylamino)methyl)-6-(3-hydroxyphenyl)isonicotinic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL470852; BDBM50278616
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[5] | |||
| Compound Name |
3-(Thiophen-3-ylethynyl)-1H-indazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1631900; SCHEMBL12269771; BDBM50333019; ZINC66252788
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
3-(1,2,3,4-Tetrahydronaphthalen-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1241440; 3-(1,2,3,4-tetrahydronaphthalen-2-yl)-2H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
6-[(2,3-Dichlorophenyl)methylamino]-4-morpholin-4-yl-1H-pyrimidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2158443; BDBM50393989
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[17] | |||
| Compound Name |
6-(4-Amino-1-cyclopentyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)quinolin-2(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1241864
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
3-(H-Imidazo[1,2-a]pyridin-7-yl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242665
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
1-Isopropyl-3-(2,3-dimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL3613209; CHEMBL1242751; 3-(2,3-dimethoxyphenyl)-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
N-Methyl-N-[6-(3-methylsulfonylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064503; BDBM50389410
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
1-Methyl-3-(3-phenylphenyl)pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242849
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
2-((4-Fluoro-2-methylphenylamino)methyl)-6-(2-hydroxyethylamino)isonicotinic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL469806; BDBM50278578
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[5] | |||
| Compound Name |
N-[4-[4-(Methylsulfonylmethyl)-6-morpholin-4-yl-pyrimidin-2-yl]phenyl]methanesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2030449; SCHEMBL4530579; BDBM50384245; N-[4-[4-(methylsulfonylmethyl)-6-morpholin-4-ylpyrimidin-2-yl]phenyl]methanesulfonamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
trans-4-[[[6-[1-(Cyclopropylmethyl)-1,2-dihydro-2-oxo-4-pyridinyl]-2-benzothiazolyl]amino]methyl]-cyclohexanecarboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
AZ044; CHEMBL3600785; BDBM50107257; SB19683
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[21] | |||
| Compound Name |
N-[7-Methyl-6-(5-methylsulfonylpyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064566; BDBM50389416
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
2-((4-Fluoro-2-methylphenylamino)methyl)-6-((2-hydroxyethyl)(methyl)amino)isonicotinic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL512487; BDBM50278577
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
2-Chloro-6-((4-fluoro-2-methylphenylamino)methyl)isonicotinic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL502174; BDBM50278656
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
2-((4-Fluoro-2-methylphenylamino)methyl)-6-(4-hydroxyphenyl)isonicotinic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL470639; BDBM50278615
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[5] | |||
| Compound Name |
Tert-butyl 5-(4-amino-1-cyclopentyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-1H-indole-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL3604275; CHEMBL1242853; tert-butyl 5-(4-amino-1-cyclopentylpyrazolo[3,4-d]pyrimidin-3-yl)indole-1-carboxylate
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
3-(3-(2,6-Dichlorobenzyloxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242292; 3-[3-[(2,6-dichlorophenyl)methoxy]phenyl]-2H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
8-Methyl-7-[2-(4-methylpiperazin-1-yl)ethoxy]-2-morpholin-4-yl-1,3-benzoxazin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL244672; BDBM50401468
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
6-Pyrimidin-2-yl-1,3-benzothiazol-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3600702; BDBM50106927
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
2-((1H-Indazol-3-yl)ethynyl)aniline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1631898; BDBM50333021
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
6-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)quinolin-2(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1241863
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
3-(Pyridin-2-ylethynyl)-1H-indazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1631894; SCHEMBL12269783; BDBM50333025; ZINC66251528
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
2-((4-Fluoro-2-methylphenylamino)methyl)-N-(2-hydroxyethyl)-6-(2-hydroxyethylamino)isonicotinamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL470855; BDBM50278657
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
5-(4-Amino-1-((piperidin-3-yl)methyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-chlorophenol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1241858
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
3-(Cyclopropylethynyl)-1H-indazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1631897; SCHEMBL12269671; BDBM50333022
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
N-[6-[3-(Benzylsulfamoyl)-4-methoxyphenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-yl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2062546; BDBM50389402
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
3-(Cyclopentylethynyl)-1H-indazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1631896; SCHEMBL12269835; BDBM50333023
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
3-(3-Phenoxyphenyl)-2H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242205
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
6-((4-Fluoro-2-methylphenylamino)methyl)-2,3''-bipyridine-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL470638; BDBM50278614
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
N-[5-Methyl-6-(5-methylsulfonylpyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064567; SCHEMBL3087594; BDBM50389417
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
N-[6-(2-Methoxyphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064478; SCHEMBL3098937; BDBM50389389
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
N-[6-(4-Methylsulfonylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064487; BDBM50389399
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
(2-((4-Fluoro-2-methylphenylamino)methyl)-6-(3-hydroxypyrrolidin-1-yl)pyridin-4-yl)(3-hydroxypyrrolidin-1-yl)methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL471057; BDBM50278658
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
3-(4-Biphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL5065122; CHEMBL1242850; 3-(4-phenylphenyl)-2H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
6-(5-Methylsulfonylpyridin-3-yl)-8-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064568; BDBM50389418
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
N-[6-(5-Methylsulfonylpyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]methanesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064506; BDBM50389411
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
5-(4-Amino-1-((4-phenyloxazol-5-yl)methyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-fluorophenol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1241482
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
2-((4-Fluoro-2-methylphenylamino)methyl)-6-(2-hydroxyphenyl)isonicotinic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL470853; BDBM50278617
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
1-[6-[5-(Tert-butylsulfamoyl)pyridin-3-yl]-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-3-phenylurea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2057359; BDBM50387533
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[26] | |||
| Compound Name |
6-[2-Hydroxypropyl(naphthalen-1-ylmethyl)amino]-4-morpholin-4-yl-1H-pyrimidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2165183; BDBM50395810
Click to Show/Hide
|
||||
| Activity |
IC50 = 112000 nM
|
[16] | |||
| Compound Name |
5-Fluoro-2-[(1S)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)propyl]-3-[3-(2,2,2-trifluoroethoxy)phenyl]quinazolin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3944735; SCHEMBL16108305; BDBM197723; US9216985, 11A
Click to Show/Hide
|
||||
| Activity |
IC50 = 115000 nM
|
[27] | |||
| Compound Name |
[2-(Benzylamino)-6-morpholin-4-ylpyridin-4-yl]methanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2158435; BDBM50393995
Click to Show/Hide
|
||||
| Activity |
IC50 = 119000 nM
|
[17] | |||
| Compound Name |
4-(1-(7-Fluoro-3-methyl-2-(2-pyridinyl)-4-quinolinyl)-3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-6-methyl-2-pyrimidinamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2171928; SCHEMBL2124906; BDBM50396615
Click to Show/Hide
|
||||
| Activity |
Ki ~ 125000 nM
|
[2] | |||
| Compound Name |
N-[2-Methyl-6-[2-[(1-methylpyrazol-3-yl)amino]-6-(1-propan-2-ylpyrazol-4-yl)imidazo[1,2-a]pyridin-3-yl]pyrimidin-4-yl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2172478; BDBM50396295
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 125000 nM
|
[28] | |||
| Compound Name |
3-(4-Fluorophenyl)-7,8-dihydroxychromen-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4286485; Oprea1_446422; Oprea1_857631; 3-(4-fluorophenyl)-7,8-dihydroxy-4H-chromen-4-one; SCHEMBL10558084; ZINC6557424; BDBM50467464; STK973480; AKOS000523057; MCULE-9534726208
Click to Show/Hide
|
||||
| Activity |
EC50 = 139600 nM
|
[19] | |||
| Compound Name |
2-(Benzylamino)-6-morpholin-4-yl-1H-pyridin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2158426; BDBM50393977
Click to Show/Hide
|
||||
| Activity |
IC50 = 142000 nM
|
[17] | |||
| Compound Name |
4-Morpholin-4-yl-6-[[(1R)-1-naphthalen-1-ylethyl]amino]-1H-pyrimidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2158445; BDBM50393994
Click to Show/Hide
|
||||
| Activity |
IC50 = 146000 nM
|
[17] | |||
| Compound Name |
6-[2-Hydroxybutyl(naphthalen-1-ylmethyl)amino]-4-morpholin-4-yl-1H-pyrimidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2165184; BDBM50395809
Click to Show/Hide
|
||||
| Activity |
IC50 = 149000 nM
|
[16] | |||
| Compound Name |
6-(6-Methylsulfonylpyridin-3-yl)-1,3-benzothiazol-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3600693; BDBM50107268
Click to Show/Hide
|
||||
| Activity |
IC50 = 158489.32 nM
|
[21] | |||
| Compound Name |
4-(4-Hydroxypiperidin-1-yl)-2-(naphthalen-1-ylmethylamino)-1H-pyrimidin-6-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2165194; BDBM50395818
Click to Show/Hide
|
||||
| Activity |
IC50 = 160000 nM
|
[16] | |||
| Compound Name |
2-(4-Fluorophenyl)-1-(2,3,4-trihydroxyphenyl)ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL486077; Oprea1_455025; Oprea1_660409; SCHEMBL10558859; ZINC301217; BDBM50467443; STK968273; AKOS001038103; MCULE-8347519233; ST50999300; SR-01000314088; SR-01000314088-1; 2-(4-fluorophenyl)-1-(2,3,4-trihydroxyphenyl)ethan-1-one
Click to Show/Hide
|
||||
| Activity |
EC50 = 170400 nM
|
[19] | |||
| Compound Name |
2-(4-Chlorophenyl)-1-(2,4-dihydroxyphenyl)ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1077251; Ethanone,2-(4-chlorophenyl)-1-(2,4-dihydroxyphenyl)-; 1-(2,4-dihydroxyphenyl)-2-(4-chlorophenyl)ethan-1-one; Oprea1_427565; Oprea1_780217; SCHEMBL3586687; CTK4C8427; ZINC58236; DTXSID00342977; 2,4-Dihydroxy-4'-chlorodeoxybenzoin; 4814AH; BDBM50467444; MFCD00499120; SBB015373; STK878820; AKOS000273243; CCG-103621; MCULE-5770510847; EU-0000913; ST50071301; SR-01000395038; SR-01000395038-1; 2-(4-chlorophenyl)-1-(2,4-dihydroxy-phenyl)ethanone; 2-(4-Chlorophenyl)-1-(2,4-dihydroxyphenyl)-ethanone; 2-(4-Chlorophenyl)-1-(2,4-dihydroxyphenyl)ethanone #; F0900-1866
Click to Show/Hide
|
||||
| Activity |
EC50 = 196000 nM
|
[19] | |||
| Compound Name |
1-(Cyclopropylmethyl)-4-[2-(oxan-4-ylmethylamino)-1,3-benzothiazol-6-yl]pyridin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3600781; BDBM50107248
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 199526.23 nM
|
[21] | |||
| Compound Name |
1-(Cyclopropylmethyl)-4-[2-[[(1R)-1-(oxan-4-yl)ethyl]amino]-1,3-benzothiazol-6-yl]pyridin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3600782; BDBM50107254
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 199526.23 nM
|
[21] | |||
| Compound Name |
1-(Cyclopropylmethyl)-4-[2-[[(1S)-1-(oxan-4-yl)ethyl]amino]-1,3-benzothiazol-6-yl]pyridin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3600783; BDBM50107255
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 199526.23 nM
|
[21] | |||
| Compound Name |
Click to Show/Hide
|
Compound Info | |||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 44 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
PMID28870136-Compound-48
Click to Show/Hide
|
Patented | Compound Info | ||
| Activity |
IC50 = 300000 nM
|
[3] | |||
| Compound Name |
PMID28870136-Compound-52
Click to Show/Hide
|
Patented | Compound Info | ||
| Activity |
IC50 = 400000 nM
|
[3] | |||
| Compound Name |
BENZOIN
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BENZOIN; 119-53-9; 2-Hydroxy-1,2-diphenylethanone; 2-Hydroxy-2-phenylacetophenone; Benzoylphenylcarbinol; Benzoin tincture; Ethanone, 2-hydroxy-1,2-diphenyl-; Bitter almond oil camphor; Phenylbenzoyl carbinol; 2-hydroxy-1,2-diphenylethan-1-one; (+-)-Benzoin; DL-BENZOIN; alpha-Hydroxybenzyl phenyl ketone; 579-44-2; alpha-Hydroxy-alpha-phenylacetophenone; Benzoin resin; Phenyl-alpha-hydroxybenzyl ketone; NCI-C50011; Acetophenone, 2-hydroxy-2-phenyl-; Benzoin gum; Bitter-almond-oil camphor; Benzoin Siam; Benzoin extract (resinoid)
Click to Show/Hide
|
||||
| Activity |
IC50 = 2120000 nM
|
[29] | |||
| Compound Name |
2-((9H-Purin-6-ylthio)methyl)-5-chloro-3-(2-methoxyphenyl)quinazolin-4(3H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
PIK-39; CHEMBL1213083; SCHEMBL369837; BDBM50323727; ZINC16052698; DB06831; CU-00000000270-1; Q27095735
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[30] | |||
| Compound Name |
6-[(3-Hydroxy-2,2-dimethylpropyl)-(naphthalen-1-ylmethyl)amino]-4-morpholin-4-yl-1H-pyrimidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2165186; BDBM50395807
Click to Show/Hide
|
||||
| Activity |
IC50 = 205000 nM
|
[16] | |||
| Compound Name |
6-[Methyl(naphthalen-1-ylmethyl)amino]-4-morpholin-4-yl-1H-pyrimidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2165177; BDBM50395816
Click to Show/Hide
|
||||
| Activity |
IC50 = 212000 nM
|
[16] | |||
| Compound Name |
Methyl 2-(benzylamino)-6-morpholin-4-ylpyridine-4-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2158434; BDBM50393978
Click to Show/Hide
|
||||
| Activity |
IC50 = 240000 nM
|
[17] | |||
| Compound Name |
Ethanone, 2-(3,4-dimethoxyphenyl)-1-(2,3,4-trihydroxyphenyl)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL563494; ACMC-20lxm4; CTK3F6062; DTXSID90552922; BDBM50295966; 2,3,4-Trihydroxy-3'',4''-dimethoxydeoxybenzoin; 2-(3,4-dimethoxyphenyl)-1-(2,3,4-trihydroxyphenyl)ethanone; 2-(3,4-Dimethoxyphenyl)-1-(2,3,4-trihydroxyphenyl)ethan-1-one
Click to Show/Hide
|
||||
| Activity |
EC50 = 242000 nM
|
[19] | |||
| Compound Name |
Chembl4295167
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50467469
Click to Show/Hide
|
||||
| Activity |
EC50 = 242300 nM
|
[19] | |||
| Compound Name |
Chembl4229035
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50460339
Click to Show/Hide
|
||||
| Activity |
IC50 = 250000 nM
|
[31] | |||
| Compound Name |
4-(Benzylamino)-2-morpholin-4-yl-1H-pyrimidin-6-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2158425; BDBM50393993
Click to Show/Hide
|
||||
| Activity |
IC50 = 283000 nM
|
[17] | |||
| Compound Name |
Chembl4228200
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50460340
Click to Show/Hide
|
||||
| Activity |
IC50 = 290000 nM
|
[31] | |||
| Compound Name |
4-[2-[3-(Methoxymethyl)phenyl]-6-(methylsulfonylmethyl)pyrimidin-4-yl]morpholine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2030444; BDBM50384257
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[23] | |||
| Compound Name |
4H-1-Benzopyran-4-one, 3-(3,4-dimethoxyphenyl)-7,8-dihydroxy-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1290567; ACMC-20m1pv; SCHEMBL10563073; CTK3G8098; DTXSID50552923; BDBM50467450; 7,8-Dihydroxy-3',4'-dimethoxyisoflavone; 3-(3,4-Dimethoxyphenyl)-7,8-dihydroxy-4H-1-benzopyran-4-one; 3-(3,4-DIMETHOXYPHENYL)-7,8-DIHYDROXYCHROMEN-4-ONE
Click to Show/Hide
|
||||
| Activity |
EC50 = 335500 nM
|
[19] | |||
| Compound Name |
6-[2-Hydroxyethyl(naphthalen-1-ylmethyl)amino]-4-[(2R)-2-methylmorpholin-4-yl]-1H-pyrimidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2165190; BDBM50395804
Click to Show/Hide
|
||||
| Activity |
IC50 = 349000 nM
|
[16] | |||
| Compound Name |
Chembl4279224
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50467463
Click to Show/Hide
|
||||
| Activity |
EC50 > 500000 nM
|
[19] | |||
| Compound Name |
Chembl4290972
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Cambridge id 6627572; DTXSID00417674; ZINC6557553; BDBM50467462; AKOS001220568; MCULE-6590793744; SR-01000239284; SR-01000239284-1; T5512514; 3-(2-chlorophenyl)-7,8-dihydroxy-4H-chromen-4-one; Z57147676
Click to Show/Hide
|
||||
| Activity |
EC50 > 500000 nM
|
[19] | |||
| Compound Name |
Chembl4287871
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50467449
Click to Show/Hide
|
||||
| Activity |
EC50 > 500000 nM
|
[19] | |||
| Compound Name |
Chembl4294362
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50467446
Click to Show/Hide
|
||||
| Activity |
EC50 > 500000 nM
|
[19] | |||
| Compound Name |
2-(2-Chlorophenyl)-1-(2,3,4-trihydroxyphenyl)ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109028; DTXSID10387738; ZINC4755035; BDBM50467452; NSC731312; MCULE-6101932657; NSC-731312
Click to Show/Hide
|
||||
| Activity |
EC50 > 500000 nM
|
[19] | |||
| Compound Name |
Chembl4293291
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50467460
Click to Show/Hide
|
||||
| Activity |
EC50 > 500000 nM
|
[19] | |||
| Compound Name |
Chembl4291276
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Oprea1_512012; BDBM50467453
Click to Show/Hide
|
||||
| Activity |
EC50 > 500000 nM
|
[19] | |||
| Compound Name |
(2-Oxo-1,2-diphenylethyl) 4-chlorobenzoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3601177; Oprea1_667243; BDBM50107317; AKOS001026175; AKOS016182944; MCULE-3594952598
Click to Show/Hide
|
||||
| Activity |
IC50 = 730000 nM
|
[29] | |||
| Compound Name |
(2-Oxo-1,2-diphenylethyl) 4-nitrobenzoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3601173; SCHEMBL14662793; BDBM50107321
Click to Show/Hide
|
||||
| Activity |
IC50 = 880000 nM
|
[29] | |||
| Compound Name |
2-Oxo-1,2-diphenylethyl 2-fluorobenzoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3601174; Oprea1_552558; BDBM50107320; AKOS033709748; MCULE-9548120734; Z19797247
Click to Show/Hide
|
||||
| Activity |
IC50 = 910000 nM
|
[29] | |||
| Compound Name |
2-Oxo-1,2-diphenylethyl 3-fluorobenzoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3601175; Oprea1_620653; BDBM50107319; AKOS002288931; ST50780605
Click to Show/Hide
|
||||
| Activity |
IC50 = 970000 nM
|
[29] | |||
| Compound Name |
Methyl (6-morpholino-2-phenyl-4-pyrimidinyl)methyl sulfone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2030440; 4-[6-(methanesulfonylmethyl)-2-phenylpyrimidin-4-yl]morpholine; Oprea1_461953; SCHEMBL1271420; 4-[6-(methylsulfonylmethyl)-2-phenylpyrimidin-4-yl]morpholine; KS-000037TP; ZINC1388926; BDBM50384262; AKOS005090371; 4L-550S; MCULE-6477976264
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[23] | |||
| Compound Name |
2-Hydroxy-1,2-bis(4-methoxyphenyl)ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Anisoin; 4,4'-Dimethoxybenzoin; p-Anisoin; Ethanone, 2-hydroxy-1,2-bis(4-methoxyphenyl)-; MFCD00008411; Benzoin, 4,4'-dimethoxy-; Anisoin, 95%; Benzoin,4'-dimethoxy-; 4,4'-Anisoin; p,p'-Dimethoxybenzoin; 1,2-bis(4-methoxyphenyl)-2-hydroxyethan-1-one; NSC8504; NSC 7960; EINECS 204-330-8; p-Anisoin (8CI); 4,4'-bismethoxybenzoin; AI3-23357; 4,4\\'-Dimethoxybenzoin; TimTec1_001608; Oprea1_009659; SCHEMBL68736; Benzil-related compound, 38; ACMC-209a33; CHEMBL370299; 4,4'-Dimethoxybenzoin, 95%; BDBM22760; KS-00000FNJ; LRRQSCPPOIUNGX-UHFFFAOYSA-; DTXSID60883311; NSC7960; HMS1538J02; EBD96556; NSC-7960; NSC-8504; 3346AA; ANW-17341; SBB006267; STK803148; AKOS003239372; AKOS016038120; MCULE-4924541341; NCGC00174251-01; AK-90133; DS-16803; Hydroxy-1,2-bis(4-methoxyphenyl)ethanone; ST023482; SY019730; 1,2-di-(4-methoxyphenyl)-2-oxo-ethanol; DB-041475; FT-0622404; 2-Hydroxy-1,2-bis(4-methoxyphenyl);ethanone; 2-Hydroxy-1,2-bis(4-methoxyphenyl)ethanone #; 4,4 inverted exclamation mark -Dimethoxybenzoin; 2-hydroxy-1,2-bis(4-methoxyphenyl)ethan-1-one; W-108509; 2-Hydroxy-4'-methoxy-2-(4-methoxyphenyl)acetophenone; F1638-0096; (alpha-Hydroxy-4-methoxybenzyl)-(4-methoxyphenyl)-ketone
Click to Show/Hide
|
||||
| Activity |
IC50 = 1170000 nM
|
[29] | |||
| Compound Name |
2-Oxo-1,2-diphenylethyl 4-fluorobenzoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3601176; Oprea1_110511; SCHEMBL6203117; BDBM50107318; STK388431; AKOS003647714; MCULE-8533039237; ST45158721; AN-652/12623071; SR-01000423995; SR-01000423995-1
Click to Show/Hide
|
||||
| Activity |
IC50 = 1290000 nM
|
[29] | |||
| Compound Name |
Desyl benzoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-Oxo-1,2-diphenylethyl benzoate; benzoin benzoate; (2-oxo-1,2-diphenylethyl) benzoate; CHEMBL3601172; Ethanone, 2-(benzoyloxy)-1,2-diphenyl-; DL-BENZOIN BENZOATE; NCIOpen2_007901; Oprea1_078052; SCHEMBL343011; NSC60084; BDBM50107322; NSC-60084; 2-Oxo-1,2-diphenylethyl benzoate #; AKOS002910672; MCULE-4784302511; FT-0624528; ST50444831
Click to Show/Hide
|
||||
| Activity |
IC50 = 2660000 nM
|
[29] | |||
| Compound Name |
[1,2-Bis(4-methoxyphenyl)-2-oxoethyl] 4-fluorobenzoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3601178; BDBM50107316
Click to Show/Hide
|
||||
| Activity |
IC50 = 2820000 nM
|
[29] | |||
| Compound Name |
5-(2-Amino-5-fluoro-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-tert-butylpyridine-3-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2205763; SCHEMBL3258676; BDBM50401150
Click to Show/Hide
|
||||
| Activity |
IC50 = 3981071.71 nM
|
[32] | |||
| Compound Name |
CID 44621448
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2205767; SCHEMBL3222900; BDBM50401153; 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-(2,2,2-trifluoroethyl)pyridine-3-sulfonamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 7943282.35 nM
|
[32] | |||
| Compound Name |
5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N,N-diethylpyridine-3-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2205771; SCHEMBL3226533; BDBM50401144
Click to Show/Hide
|
||||
| Activity |
IC50 = 7943282.35 nM
|
[32] | |||
| Compound Name |
5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-benzylpyridine-3-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2205770; SCHEMBL3225926; BDBM50401145
Click to Show/Hide
|
||||
| Activity |
IC50 = 10000000 nM
|
[32] | |||
| Compound Name |
CID 44621449
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2205768; SCHEMBL13536557; BDBM50401147
Click to Show/Hide
|
||||
| Activity |
IC50 = 10000000 nM
|
[32] | |||
| Compound Name |
7-[5-(2,2-Dimethylazetidin-1-yl)sulfonylpyridin-3-yl]-[1,2,4]triazolo[1,5-a]pyridin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2205772; BDBM50401146
Click to Show/Hide
|
||||
| Activity |
IC50 = 12589254.12 nM
|
[32] | |||
| Compound Name |
5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-propylpyridine-3-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2205764; SCHEMBL3234064; BDBM50401151
Click to Show/Hide
|
||||
| Activity |
IC50 = 12589254.12 nM
|
[32] | |||
| Compound Name |
5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-methylpyridine-3-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2205774; SCHEMBL3234736; BDBM50401143
Click to Show/Hide
|
||||
| Activity |
IC50 = 12589254.12 nM
|
[32] | |||
| Compound Name |
5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-propan-2-ylpyridine-3-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2205765; SCHEMBL3226438; BDBM50401148
Click to Show/Hide
|
||||
| Activity |
IC50 = 12589254.12 nM
|
[32] | |||
| Compound Name |
5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)pyridine-3-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2205773; SCHEMBL3228404; BDBM50401149
Click to Show/Hide
|
||||
| Activity |
IC50 = 15848931.92 nM
|
[32] | |||
| Compound Name |
5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-tert-butylpyridine-3-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2205766; SCHEMBL3226712; BDBM50401152; ZINC95562659
Click to Show/Hide
|
||||
| Activity |
IC50 = 19952623.15 nM
|
[32] | |||
| Compound Name |
7-(5-Methylsulfonylpyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2203312; SCHEMBL3262808; BDBM50401141
Click to Show/Hide
|
||||
| Activity |
IC50 = 19952623.15 nM
|
[32] | |||
| Compound Name |
5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-phenylpyridine-3-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2205769; SCHEMBL3232284; BDBM50401142
Click to Show/Hide
|
||||
| Activity |
IC50 = 39810717.06 nM
|
[32] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
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| REF 2 | Discovery and in vivo evaluation of dual PI3K/ inhibitors. J Med Chem. 2012 Sep 13;55(17):7667-85. | ||||
| REF 3 | Small molecules targeting phosphoinositide 3-kinases. Medchemcomm. 2012;3:1337-55. | ||||
| REF 4 | Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and... J Med Chem. 2005 Jan 27;48(2):569-85. | ||||
| REF 5 | Exploring the PI3K alpha and gamma binding sites with 2,6-disubstituted isonicotinic derivatives. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2215-9. | ||||
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| REF 8 | Rational Design, Synthesis, and SAR of a Novel Thiazolopyrimidinone Series of Selective PI3K-beta Inhibitors. ACS Med Chem Lett. 2012 May 29;3(7):524-9. | ||||
| REF 9 | Design, synthesis, and biological activity of pyridopyrimidine scaffolds as novel PI3K/mTOR dual inhibitors. J Med Chem. 2014 Feb 13;57(3):613-31. | ||||
| REF 10 | 4-(1,3-Thiazol-2-yl)morpholine derivatives as inhibitors of phosphoinositide 3-kinase. Bioorg Med Chem Lett. 2008 Aug 1;18(15):4316-20. | ||||
| REF 11 | Discovery of novel 2-piperidinol-3-(arylsulfonyl)quinoxalines as phosphoinositide 3-kinase alpha (PI3Kalpha) inhibitors. Bioorg Med Chem. 2012 May 1;20(9):2837-44. | ||||
| REF 12 | Discovery of novel morpholino-quinoxalines as PI3Kalpha inhibitors by pharmacophore-based screening. Medchemcomm. 2012;3:659-62. | ||||
| REF 13 | Design, synthesis, and structure-activity relationships of 3-ethynyl-1H-indazoles as inhibitors of the phosphatidylinositol 3-kinase signaling pathway. J Med Chem. 2010 Dec 9;53(23):8368-75. | ||||
| REF 14 | Hit to lead optimization of pyrazolo[1,5-a]pyrimidines as B-Raf kinase inhibitors. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6890-2. | ||||
| REF 15 | SAR studies around a series of triazolopyridines as potent and selective PI3K inhibitors. Bioorg Med Chem Lett. 2012 Aug 15;22(16):5257-63. | ||||
| REF 16 | Discovery of phosphoinositide 3-kinases (PI3K) p110 isoform inhibitor 4-[2-hydroxyethyl(1-naphthylmethyl)amino]-6-[(2S)-2-methylmorpholin-4-yl]-1H-pyrimidin-2-one, an effective antithrombotic agent without associated bleeding and insulin resistance. Bioorg Med Chem Lett. 2012 Nov 1;22(21):6671-6. | ||||
| REF 17 | Discovery of 4-morpholino-pyrimidin-6-one and 4-morpholino-pyrimidin-2-one-containing Phosphoinositide 3-kinase (PI3K) p110 isoform inhibitors through structure-based fragment optimisation. Bioorg Med Chem Lett. 2012 Nov 1;22(21):6665-70. | ||||
| REF 18 | Computer-aided design, synthesis, and biological evaluation of new indole-2-carboxamide derivatives as PI3Kalpha/EGFR inhibitors. Bioorg Med Chem Lett. 2016 Jun 1;26(11):2685-90. | ||||
| REF 19 | Synthesis, biological evaluation and structure-activity relationship of a novel class of PI3Kalpha H1047R mutant inhibitors. Eur J Med Chem. 2018 Oct 5;158:707-19. | ||||
| REF 20 | Discovery of novel class 1 phosphatidylinositide 3-kinases (PI3K) fragment inhibitors through structure-based virtual screening. Bioorg Med Chem Lett. 2011 Jan 15;21(2):829-35. | ||||
| REF 21 | Discovery of potent, selective small molecule inhibitors of alpha-subtype of type III phosphatidylinositol-4-kinase (PI4KIIIalpha). Bioorg Med Chem Lett. 2015 Aug 15;25(16):3189-93. | ||||
| REF 22 | The p110 delta structure: mechanisms for selectivity and potency of new PI(3)K inhibitors. Nat Chem Biol. 2010 Feb;6(2):117-24. | ||||
| REF 23 | Sulfonyl-morpholino-pyrimidines: SAR and development of a novel class of selective mTOR kinase inhibitor. Bioorg Med Chem Lett. 2012 Jun 15;22(12):4163-8. | ||||
| REF 24 | US patent application no. 8937068B2, Pyridopyrazine derivatives and their use | ||||
| REF 25 | Synthesis, DNA-PK inhibition, anti-platelet activity studies of 2-(N-substituted-3-aminopyridine)-substituted-1,3-benzoxazines and DNA-PK and PI3K inhibition, homology modelling studies of 2-morpholino-(7,8-di and 8-substituted)-1,3-benzoxazines. Eur J Med Chem. 2012 Nov;57:85-101. | ||||
| REF 26 | Discovery of novel PI3K/ inhibitors as potential agents for inflammation. Bioorg Med Chem Lett. 2012 Jul 15;22(14):4546-9. | ||||
| REF 27 | US patent application no. 9216985B2, 3-aryl-2-((arylamino)methyl)quinazolin-4-(3H)-ones | ||||
| REF 28 | Discovery and optimization of potent and selective imidazopyridine and imidazopyridazine mTOR inhibitors. Bioorg Med Chem Lett. 2012 Aug 1;22(15):4967-74 | ||||
| REF 29 | Molecular modeling based approach, synthesis, and cytotoxic activity of novel benzoin derivatives targeting phosphoinostide 3-kinase (PI3Kalpha). Bioorg Med Chem Lett. 2015 Aug 15;25(16):3120-4. | ||||
| REF 30 | PI3K and PI3K as targets for autoimmune and inflammatory diseases. J Med Chem. 2012 Oct 25;55(20):8559-81. | ||||
| REF 31 | Design and synthesis of 1,4-substituted 1H-1,2,3-triazolo-quinazolin-4(3H)-ones by Huisgen 1,3-dipolar cycloaddition with PI3K isoform selective activity. Bioorg Med Chem Lett. 2018 Apr 1;28(6):1005-1010. | ||||
| REF 32 | Discovery of 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-(tert-butyl)pyridine-3-sulfonamide (CZC24758), as a potent, orally bioavailable and selective inhibitor of PI3K for the treatment of inflammatory disease. Bioorg Med Chem Lett. 2012 Jul 15;22(14):4613-8. | ||||
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