Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T80975 | Target Info | |||
| Target Name | Vascular endothelial growth factor receptor 2 (KDR) | ||||
| Synonyms |
VEGFR2; VEGFR-2; VEGF-2 receptor; Protein-tyrosine kinase receptor flk-1; Kinase insert domain receptor; Fetal liver kinase 1; FLK1; FLK-1; CD309
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| Target Type | Successful Target | ||||
| Gene Name | KDR | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 305 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Dasatinib
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Approved | Compound Info | ||
| Synonyms |
Sprycel (TN); BMS 354825; BMS-354825; BMS-354825, Sprycel, BMS354825, Dasatinib; BMS354825; Dasatinib (USAN); Dasatinib [USAN]; Dasatinib anhydrous; Dasatinib, BMS 354825; Dasatinibum; Sprycel; Spyrcel
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Erlotinib
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Approved | Compound Info | ||
| Synonyms |
Erlotinin; Tarceva; Erlotinib Base; OSI 744; R 1415; CP 358,774; CP-358774; Erlotinib(Tarceva); Tarceva (TN); CP-358,774; Erlotinib, OS-774; N-(3-ethynylphenyl)[6,7-bis(2-methoxyethoxy)quinazolin-4-yl]amine; N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine; N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine; N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-Quinazolinamine; [6,7-BIS(2-METHOXY-ETHOXY)QUINAZOLINE-4-YL]-(3-ETHYNYLPHENYL)AMINE; [6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)-amine; 4-[(3-Ethynylphenyl)amino]-6,7-bis(2-methoxyethoxy)quinazoline; 4-[(3-ethynylphenyl)amino]-6,7-bis(2-methoxyethoxy)quinazoline
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| Activity |
IC50 = 124700 nM
|
[2] | |||
| Compound Name |
KENPAULLONE
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Patented | Compound Info | ||
| Synonyms |
kenpaullone; 142273-20-9; 9-Bromopaullone; NSC 664704; 9-Bromo-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one; NSC-664704; NSC664704; MLS002702152; CHEMBL296586; 9-Bromo-7,12-dihydroindolo(3,2-d)(1)benzazepin-6(5H)-one; Indolo[3,2-d][1]benzazepin-6(5H)-one,9-bromo-7,12-dihydro-; QQUXFYAWXPMDOE-UHFFFAOYSA-N; 9-Bromo-7,12-dihydro-indolo[3,2-d][1]benzazepin-6(5H)-one; 9-bromo-7,12-dihydro-5H-indolo[3,2-d][1]benzazepin-6-one; 9-Bromo-7,12-dihydro-indolo-[3,2-d]-[1]benzazepin-6(5H)-one
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
A-770041
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Investigative | Compound Info | ||
| Synonyms |
A-770041; 869748-10-7; UNII-U9855G2ZPR; U9855G2ZPR; CHEMBL197603; KIN001-111; N-(4-{1-[4-(4-Acetylpiperazin-1-Yl)-Trans-Cyclohexyl]-4-Amino-1h-Pyrazolo[3,4-D]pyrimidin-3-Yl}-2-Methoxyphenyl)-1-Methyl-1h-Indole-2-Carboxamide; A 770041; Kinome_3267; 2c0o; MLS006010241; CHEMBL1970879; SCHEMBL15705796; CHEBI:91457; MolPort-039-139-535; C34H39N9O3; 3413AH; ZINC14210723; BDBM50175196; ABP001109; AKOS030526954; ZINC253387967; CS-0057; NCGC00386613-01; NCGC00346955-01; SMR004701317; HY-11011; L2G; 1H-Indole-2-carboxamide, N-(4-(1-(trans-4-(4-
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
A-420983
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL314627; A-420983; N-(4-{4-Amino-1-[4-(4-Methylpiperazin-1-Yl)-Trans-Cyclohexyl]-1h-Pyrazolo[3,4-D]pyrimidin-3-Yl}-2-Methoxyphenyl)-1-Methyl-1h-Indole-2-Carboxamide; SCHEMBL6221049; SCHEMBL5803074; SCHEMBL19999345; SCHEMBL14106773; SCHEMBL16752208; STVKLDUINKMZFE-RQNOJGIXSA-N; STVKLDUINKMZFE-PSWAGMNNSA-N; BDBM50145571; L1G; N-(4-(4-amino-1-((trans)-4-(4-methylpiperazin-1-yl)cyclohexyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-methoxyphenyl)-1-methyl-1H-indole-2-carboxamide
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
3-(4-morpholinothieno[3,2-d]pyrimidin-2-yl)phenol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL541643
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| Activity |
IC50 = 91000 nM
|
[6] | |||
| Compound Name |
3-Substituted indolin-2-one 11c
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Investigative | Compound Info | ||
| Synonyms |
SU5402 analog 11c; BDBM4889; CHEMBL146697; SCHEMBL4407240; 3-[4-Methyl-5-(2-oxo-5-sulfamoyl-1,2-dihydroindol-3-ylidenemethyl)-1H-pyrrol-3-yl]propionic Acid
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| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
1-[4-(3-Methyl-2H-pyrazolo[3,4-b]pyridin-4-yl)phenyl]-3-naphthalen-2-ylurea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4071160; BDBM50238305
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| Activity |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
3-(Benzo[b]thiophen-2-yl)-6-((4-methylpiperazin-1-yl)methyl)-1,4-dihydroindeno[1,2-c]pyrazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL212083; BDBM50188278
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| Activity |
IC50 ~ 50000 nM
|
[9] | |||
| Compound Name |
N-(7-Methoxyquinolin-6-yl)thieno[3,2-d]pyrimidine-7-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL357756; CHEMBL3822972; BDBM206104; DB-085143; US9255110, 17
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| Activity |
IC50 ~ 50000 nM
|
[10] | |||
| Compound Name |
1-[4-(3-Methyl-6-oxo-2,4,5,7-tetrahydropyrazolo[3,4-b]pyridin-4-yl)phenyl]-3-(3-methylphenyl)urea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4063976; BDBM50238287
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| Activity |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
Rac-3-(6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)quinolin-3-yl)propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL591457; BDBM50306678
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| Activity |
IC50 = 50000 nM
|
[11] | |||
| Compound Name |
Rac-3-(6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)quinolin-3-yl)acrylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL602470; BDBM50306685
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| Activity |
IC50 ~ 50000 nM
|
[11] | |||
| Compound Name |
(1R,2R)-N-[4-[[4-Amino-1-[4-(4-methylpiperazin-1-yl)cyclohexyl]pyrazolo[3,4-d]pyrimidin-3-yl]methyl]-2-methoxyphenyl]-2-phenylcyclopropane-1-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL416091
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| Activity |
IC50 ~ 50000 nM
|
[12] | |||
| Compound Name |
N-[4-[4-Amino-1-[4-(4-methylpiperazin-1-yl)cyclohexyl]pyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl]-3-phenylpropanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL295601; Pyrazolo[3,4-d]pyrimidine 11; BDBM8803; SCHEMBL4824701; SCHEMBL4824706; SCHEMBL6434020
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
5-(2-Phenoxyphenyl)-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL68774; SCHEMBL7006001; BDBM50092230; 7-cyclopentyl-5-(2-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-4-amine; 7-Cyclopentyl-5-(2-phenoxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine
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| Activity |
IC50 ~ 50000 nM
|
[13] | |||
| Compound Name |
N4-(3-Bromophenyl)-6-[2-(4-methoxyphenyl)ethyl]-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL485321; BDBM50271759
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| Activity |
IC50 ~ 50000 nM
|
[14] | |||
| Compound Name |
Isoindolinone analog 16
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL185387; BDBM5884; N-[4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenyl]benzenesulfonamide
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| Activity |
IC50 ~ 50000 nM
|
[15] | |||
| Compound Name |
3-(4-Nitrophenyl)isothiazolo[5,4-d]pyrimidin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL374631; SCHEMBL4479244; CTK2E9983; DTXSID10658798; 3-(4-nitrophenyl)-[1,2]thiazolo[5,4-d]pyrimidin-4-amine; BDBM50187999; 3-(4-nitrophenyl)isothiazolo[5.4-d]pyrimidin-4-amine; 3-(4-Nitrophenyl)[1,2]thiazolo[5,4-d]pyrimidin-4-amine; Isothiazolo[5,4-d]pyrimidin-4-amine, 3-(4-nitrophenyl)-
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| Activity |
IC50 ~ 50000 nM
|
[16] | |||
| Compound Name |
Methyl 4-(6-(4-(methoxycarbonylamino)phenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
WYE-354; WYE 354; pyrazolo pyrimidine, 19; cc-506; MLS006011008; SCHEMBL300431; CHEMBL561708; GTPL9361; WYE354; BDBM35587; DTXSID00657912; C24H29N7O5; HMS3654N09; BCP02898; ZINC43013490; CCG-264882; CS-0183; SB19260; NCGC00242484-01; NCGC00242484-02; NCGC00242484-09; AC-28454; AS-55957; HY-12034; SMR004702806; BCP0726000260; DB-059456; FT-0675866; S1266; SW219671-1; X7422; W-5702; J-001552; J-514253; BRD-K77008974-001-01-6; Q27166532; mTOR Kinase Inhibitor II, WYE-354 - CAS 1062169-56-5
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| Activity |
IC50 ~ 50000 nM
|
[17] | |||
| Compound Name |
1-(3-Methylphenyl)-3-[4-[3-(trifluoromethyl)-2H-pyrazolo[3,4-b]pyridin-4-yl]phenyl]urea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4102648; BDBM50238296
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| Activity |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
3-[(E)-2-(4-Chlorophenyl)ethenyl]-N-[(2R)-2,3-dihydroxypropyl]-4-methoxybenzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1949788; SCHEMBL12134179; BDBM50364832; CH-4932748
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| Activity |
IC50 ~ 50000 nM
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[18] | |||
| Compound Name |
Methyl 4-(6-(4-aminophenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1095626; SCHEMBL3984085; BDBM50316252; methyl 4-[6-(4-aminophenyl)-4-morpholin-4-ylpyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate
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| Activity |
IC50 ~ 50000 nM
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[19] | |||
| Compound Name |
3-(2-(Hydrazine)quinolin-6-yl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1241950
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| Activity |
IC50 = 50000 nM
|
[1] | |||
| Compound Name |
4-(2-Methoxyethyl)phenol
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Investigative | Compound Info | ||
| Synonyms |
p-(2-Methoxyethyl)phenol; p-(2-Methoxyethyl) phenol; Phenol, 4-(2-methoxyethyl)-; 4-METHOXYETHYLPHENOL; UNII-PY1W0AKW8I; Metoprolol Impurity B; Metoprolol IMpurity 02; MFCD00017537; PY1W0AKW8I; CHEMBL1094369; 4-Hydroxyphenylethyl methyl ether; 4-(2'-METHOXYETHYL)PHENOL; Metoprolol Impurity I; 4-(2-methoxyethyl)-phenol; 4-(2-Methoxy ethyl)-phenol; EINECS 260-354-9; 4-Methoxy ethyl phenol; ACMC-1AUK5; 4-(2'Methoxyethyl)Phenol; EC 260-354-9; 4-(2-methoxy ethyl)phenol; 4-(2-methoxyethyl) phenol; 4-(2-methoxy ethyl) phenol; 4-(2-methoxy-ethyl)-phenol; KSC495I9L; SCHEMBL303516; p-Hydroxyphenethyl methyl ether; DTXSID2073564; CTK3J5495; ATTERCOP-CHM AT108983; 4-(2-Methoxyethyl)phenol, 97%; CS-M3678; KS-000009AQ; ZINC2566176; ANW-32571; BDBM50316786; AKOS000120544; AS00207; MCULE-8081983402; NE10781; AC-23553; TS-02027; DB-052961; FT-0616546; FT-0652026; M1167; ST50824360; W-105505; Q27286814
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| Activity |
IC50 ~ 50000 nM
|
[20] | |||
| Compound Name |
[6-Chloro-4-methyl-3-[[3-(methylsulfamoylamino)phenyl]methyl]-2-oxochromen-7-yl] N,N-dimethylcarbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3086065; SCHEMBL959662; BDBM50443366
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| Activity |
IC50 ~ 50000 nM
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[21] | |||
| Compound Name |
Chembl4208998
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Investigative | Compound Info | ||
| Synonyms |
BDBM50451034
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| Activity |
IC50 ~ 50000 nM
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[22] | |||
| Compound Name |
(2S)-1-(1H-Indol-3-yl)-3-(5-isoquinolin-6-ylpyridin-3-yl)oxy-propan-2-amine
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Investigative | Compound Info | ||
| Synonyms |
isoquinoline-pyridine, 1; isoquinoline-pyridine, 3; 5-isoquinolinyl pyridine 2; pyridine-base inhibitor 13a; CHEMBL383264; SCHEMBL6855488; BDBM15067; 13a (S-); 6-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyridin-3-yl}isoquinoline
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| Activity |
IC50 ~ 50000 nM
|
[23] | |||
| Compound Name |
Rac-3-(6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)quinolin-3-yl)-N-methylacrylamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL598912; BDBM50306680
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| Activity |
IC50 ~ 50000 nM
|
[11] | |||
| Compound Name |
3-[(4-Chloro-3-methylphenoxy)methyl]-4-methoxybenzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1952357; BDBM50364835; ZINC73292947
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| Activity |
IC50 ~ 50000 nM
|
[18] | |||
| Compound Name |
N4-(3-Bromophenyl)-2-(naphthalen-2-ylmethyl)-1H-indole-4,6-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL502015; BDBM50271908
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| Activity |
IC50 ~ 50000 nM
|
[24] | |||
| Compound Name |
1-(3-Cyanophenyl)-3-[4-(3-methyl-2H-pyrazolo[3,4-b]pyridin-4-yl)phenyl]urea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4079775; BDBM50238322
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| Activity |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
3-[(E)-2-(4-Chlorophenyl)ethenyl]-N-[(2S)-2,3-dihydroxypropyl]-4-methoxybenzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1949789; SCHEMBL12134185; BDBM50364833; CH-4932750
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| Activity |
IC50 ~ 50000 nM
|
[18] | |||
| Compound Name |
1-(2-Fluoro-5-methylphenyl)-3-[4-(3-methyl-6-oxo-2,4,5,7-tetrahydropyrazolo[3,4-b]pyridin-4-yl)phenyl]urea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4076032; BDBM50238282
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| Activity |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
3-[(E)-2-(4-Chlorophenyl)ethenyl]-4-methoxybenzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1952362; SCHEMBL1353045; BDBM50364837; CH-4631051
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| Activity |
IC50 ~ 50000 nM
|
[18] | |||
| Compound Name |
3-[4-(Benzylamino)-3-methoxyphenyl]-1-[4-(4-methylpiperazin-1-yl)cyclohexyl]pyrazolo[3,4-d]pyrimidin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL45582; Pyrazolo[3,4-d]pyrimidine 10; BDBM8802; SCHEMBL5804460; SCHEMBL6431352
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| Activity |
IC50 ~ 50000 nM
|
[12] | |||
| Compound Name |
3-(4-(5,7-Dimethylbenzo[d]oxazol-2-ylamino)phenyl)isoxazolo[5,4-d]pyrimidin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL213862; BDBM50188009
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| Activity |
IC50 ~ 50000 nM
|
[16] | |||
| Compound Name |
Benzamide,n-[4-(2,3-dihydro-1-oxo-1h-isoindol-4-yl)phenyl]-
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL361285; isoindolinone analog 15; BDBM5883; ZINC14945176; N-[4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenyl]benzamide
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| Activity |
IC50 ~ 50000 nM
|
[15] | |||
| Compound Name |
Isoindolinone analog 10j
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL185207; BDBM5913; 3-[2,6-dimethyl-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenyl]-1-(3-methylphenyl)urea
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| Activity |
IC50 ~ 50000 nM
|
[15] | |||
| Compound Name |
Serotonin hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
5-Hydroxytryptamine hydrochloride; Serotonin HCl; 3-(2-aminoethyl)-1H-indol-5-ol hydrochloride; 5-Hydroxytryptamine HCl; 1H-Indol-5-ol, 3-(2-aminoethyl)-, monohydrochloride; UNII-GKN429M9VS; MFCD00012686; 3-(2-Aminoethyl)-5-hydroxyindole hydrochloride; GKN429M9VS; CHEMBL535832; 5-Hydroxytryptamine hydrochioride; 3-(2-aminoethyl)indol-5-ol, chloride; 3-(2-aminoethyl)-1H-indol-5-ol;hydrochloride; Serotonin hydrochloride, 98+%; SMR000875214; Prestwick_447; CCRIS 4420; SR-01000075577; Serotonin, HCl; 5-HT hydrochloride; 3-(2-Aminoethyl)indol-5-ol hydrochloride; MLS001332607; MLS001332608; MLS002153834; SCHEMBL379650; Serotonin hydrochloride(5-HT); Serotonin hydrochloride, powder; 3-(2-AMINO-ETHYL)-1H-INDOL-5-OL HYDROCHLORIDE; CTK3J3022; DTXSID80165186; 5-hydroxy tryptamine hydrochloride; HMS1569B03; 3-(2-Aminoethyl)indol-5-ol HCl; BCP20357; HY-B1473; KS-00000FV4; EINECS 244-464-4; Tox21_500607; ANW-43151; s4244; SBB003418; 5-Hydroxytryptamine Hydrochloride,(S); AKOS016010442; CCG-214216; GS-3130; LP00607; MCULE-8194058321; QC-1340; 3-(2-Aminoethyl)-1H-indol-5-ol HCl; NCGC00093982-01; NCGC00093982-02; NCGC00261292-01; SC-80561; ST056223; SY061788; AB0013658; DB-043206; CS-0013171; EU-0100607; FT-0631852; S0370; SW196666-3; A16699; H 9523; H-8140; X-1770; 3-(2-aminoethyl)-1H-indol-5-ol, hydrochloride; 3-(2-aminoethyl)-1H-indol-5-ol;hydrochloride.; 3-(2-azanylethyl)-1H-indol-5-ol hydrochloride; 153S980; A809482; 5-Hydroxytryptamine hydrochloride;5-HT hydrochloride; SR-01000075577-1; SR-01000075577-5; Q27279146
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| Activity |
IC50 ~ 50000 nM
|
[20] | |||
| Compound Name |
N-[4-[4-Amino-1-[4-(4-methylpiperazin-1-yl)cyclohexyl]pyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl]-1-benzofuran-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL43773; Pyrazolo[3,4-d]pyrimidine 15; BDBM8807; SCHEMBL6430463; SCHEMBL6430468
Click to Show/Hide
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
4-(4-Methyl-1H-indol-5-ylamino)-2-(3-oxo-3-(pyrrolidin-1-yl)prop-1-enyl)thieno[2,3-b]pyridine-5-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL477817; SCHEMBL5520662; SCHEMBL5520668; BDBM50263132
Click to Show/Hide
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||||
| Activity |
IC50 ~ 50000 nM
|
[25] | |||
| Compound Name |
2-((4-Amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-(o-tolyl)quinazolin-4(3H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
PIK-294; PIK294; PIK 294; C28H23N7O2; cc-610; MLS006010993; SCHEMBL1952680; CHEMBL1241767; BDBM36411; AOB6611; DTXSID20648004; SYN1098; HMS3244E13; HMS3244E14; HMS3244F13; HMS3655P12; BCP01970; EX-A2568; s2227; ZINC62260316; AKOS026750411; CCG-269607; CS-3528; CID24905149; NCGC00346614-01; NCGC00346614-02; NCGC00346614-07; AC-32796; AK176035; AS-16244; HY-10303; QC-11467; SMR004702793; PIK-294, >=98% (HPLC); FT-0699808; SW220212-1; X7436; Z-3176; J-505227
Click to Show/Hide
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||||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
1-(3-Ethylphenyl)-3-[4-[3-(trifluoromethyl)-2H-pyrazolo[3,4-b]pyridin-4-yl]phenyl]urea
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4081793; BDBM50238265
Click to Show/Hide
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||||
| Activity |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
2-Benzyl-N4-(3-bromophenyl)-1H-indole-4,6-diamine
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL499344; BDBM50271906; 6-benzyl-N4-(3-bromophenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
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||||
| Activity |
IC50 ~ 50000 nM
|
[24] | |||
| Compound Name |
N-[4-(4-Amino-6-methylthieno[2,3-d]pyrimidin-5-yl)phenyl]benzenesulfonamide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
Thienopyrimidine deriv. 8; N-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}phenyl)benzenesulfonamide; BDBM8811; CHEMBL196044; SCHEMBL4471117; N-[4-(4-Amino-6-methylthieno[2,3-d]pyrimidin-5-yl)-phenyl]benzenesulfonamide
Click to Show/Hide
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||||
| Activity |
IC50 ~ 50000 nM
|
[26] | |||
| Compound Name |
1-{3-[(4-Chloro-3-methylphenoxy)methyl]-4-methoxyphenyl}ethan-1-one
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1340723; Ro-0123743; MLS000833787; HMS2780C17; ZINC137768; BDBM50364834; CCG-52449; AKOS008911541; MCULE-9042684864; SMR000457508; SR-01000641684-1
Click to Show/Hide
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||||
| Activity |
IC50 ~ 50000 nM
|
[18] | |||
| Compound Name |
N-[4-(4-Amino-6-methylthieno[2,3-d]pyrimidin-5-yl)phenyl]-1H-indole-2-carboxamide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
Thienopyrimidine deriv. 68; N-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}phenyl)-1H-indole-2-carboxamide; BDBM8817; CHEMBL196934; SCHEMBL4480136; N-[4-(4-Amino-6-methylthieno[2,3-d]pyrimidin-5-yl)-phenyl]-1H-indole-2-carboxamide
Click to Show/Hide
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||||
| Activity |
IC50 ~ 50000 nM
|
[26] | |||
| Compound Name |
N-((4-(6-((4-Methylpiperazin-1-yl)methyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)thiophen-2-yl)methyl)(phenyl)methanesulfonamide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL211567; BDBM50188734
Click to Show/Hide
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||||
| Activity |
IC50 ~ 50000 nM
|
[27] | |||
| Compound Name |
6-Methyl-N-((5-(6-((4-methylpiperazin-1-yl)methyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)thiophen-2-yl)methyl)-1H-benzo[d]imidazol-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL443835; SCHEMBL4812219; BDBM50188765
Click to Show/Hide
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||||
| Activity |
IC50 ~ 50000 nM
|
[27] | |||
| Compound Name |
N-(4-Chlorophenyl)-5H-thiochromeno[4,3-d]pyrimidin-2-amine
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3628812; BDBM50126854
Click to Show/Hide
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||||
| Activity |
IC50 ~ 50000 nM
|
[28] | |||
| Compound Name |
1-Cyclohexyl-3-[4-(3-methyl-2H-pyrazolo[3,4-b]pyridin-4-yl)phenyl]urea
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4096138; BDBM50238284
Click to Show/Hide
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||||
| Activity |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
1-Benzyl-3-[4-(3-methyl-2H-pyrazolo[3,4-b]pyridin-4-yl)phenyl]urea
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4093186; BDBM50238292
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
8-Chloro-N-(4-methoxyphenyl)-5H-thiochromeno[4,3-d]pyrimidin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3628817; BDBM50126852
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[28] | |||
| Compound Name |
1-Ethyl-3-[4-(3-methyl-2H-pyrazolo[3,4-b]pyridin-4-yl)phenyl]urea
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4096971; BDBM50238291
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
N-(4-(4-Amino-7-(3-(4-hydroxypiperidin-1-yl)prop-1-enyl)thieno[3,2-c]pyridin-3-yl)-2-methoxyphenyl)-1-methyl-1H-indole-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL233958; SCHEMBL3527604; SCHEMBL3527605; BDBM50202741
Click to Show/Hide
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||||
| Activity |
IC50 ~ 50000 nM
|
[29] | |||
| Compound Name |
(S)-6-(1-(2,6-Dichloro-3-fluorophenyl)ethoxy)quinoline
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL598523; BDBM50306681
Click to Show/Hide
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||||
| Activity |
IC50 ~ 50000 nM
|
[11] | |||
| Compound Name |
Isoindolinone analog 20
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL183580; BDBM5889; 2-(3-methylphenyl)-N-[4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenyl]acetamide
Click to Show/Hide
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||||
| Activity |
IC50 ~ 50000 nM
|
[15] | |||
| Compound Name |
N-[4-[4-Amino-1-[4-(4-methylpiperazin-1-yl)cyclohexyl]pyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl]benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Pyrazolo[3,4-d]pyrimidine 8; BDBM8800; CHEMBL402673; SCHEMBL7698133
Click to Show/Hide
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||||
| Activity |
IC50 ~ 50000 nM
|
[12] | |||
| Compound Name |
1-[4-(3-Methyl-2H-pyrazolo[3,4-b]pyridin-4-yl)phenyl]-3-propylurea
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4069773; BDBM50238306
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
6-((4-Methylpiperazin-1-yl)methyl)-N-phenyl-1,4-dihydroindeno[1,2-c]pyrazol-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL223551; BDBM50210273
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[30] | |||
| Compound Name |
N4-(3-Bromophenyl)-6-(2-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL485320; BDBM50271758; N4-(3-bromophenyl)-6-phenethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
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||||
| Activity |
IC50 ~ 50000 nM
|
[31] | |||
| Compound Name |
N-(4-(4-Amino-7-(3-(diethylamino)prop-1-enyl)thieno[3,2-c]pyridin-3-yl)-2-methoxyphenyl)-1-methyl-1H-indole-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL232542; SCHEMBL3532542; SCHEMBL3535405; BDBM50202734
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[29] | |||
| Compound Name |
1-(2,3-Dihydro-1H-inden-2-yl)-3-[4-(3-methyl-2H-pyrazolo[3,4-b]pyridin-4-yl)phenyl]urea
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4063368; BDBM50238328
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
1-Cyclopentyl-3-(H-imidazo[1,2-a]pyridin-7-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1241675; BDBM36410; CID24905148; 1-cyclopentyl-3-(H-imidazo[1,2-a]pyridin-7-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, PP162
Click to Show/Hide
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||||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Tert-Butyl 4-(6-(4-aminophenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1095627; SCHEMBL3991434; BDBM50316253
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[19] | |||
| Compound Name |
{3-[(5-Methyl-2-Phenyl-1,3-Oxazol-4-Yl)methoxy]phenyl}methanol
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2069625; [3-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]phenyl]methanol; SCHEMBL4034790; BDBM50389606; 3-(5-methyl-2-phenyl-4-oxazolylmethoxy)benzylalcohol; Q27458508; [3-[(5-methyl-2-phenyl-4-oxazolyl)methoxy]phenyl]methanol; Benzenemethanol, 3-[(5-methyl-2-phenyl-4-oxazolyl)methoxy]-
Click to Show/Hide
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||||
| Activity |
IC50 = 50000 nM
|
[32] | |||
| Compound Name |
Pyrazolopyridazine 1a
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Kinome_3574; pyrazolopyridazine deriv. 1; Oprea1_456301; Pyrazolopyridazine deriv. 1a; BDBM7463; CHEMBL260135; SCHEMBL1226044; ZINC5224686; MCULE-4520438004; ST51002033; 4,5-diphenylpyrazolo[5,4-c]pyridazine-3-ylamine; 3-amino-4,5-diphenyl-1h-pyrazolo[3,4-c]pyridazine; 4,5-diphenyl-1H-pyrazolo[3,4-c]pyridazin-3-amine
Click to Show/Hide
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||||
| Activity |
IC50 ~ 50000 nM
|
[33] | |||
| Compound Name |
N-(4-Chlorophenyl)-8-methoxy-5H-thiochromeno[4,3-d]pyrimidin-2-amine
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3628815; BDBM50126853
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[28] | |||
| Compound Name |
N-(4-(4-Amino-7-(3-(piperidin-4-ylamino)prop-1-enyl)thieno[3,2-c]pyridin-3-yl)-2-methoxyphenyl)-1-methyl-1H-indole-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL395664; SCHEMBL3525253; SCHEMBL3525266; BDBM50202739
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[29] | |||
| Compound Name |
1-Butyl-3-[4-(3-methyl-2H-pyrazolo[3,4-b]pyridin-4-yl)phenyl]urea
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4085020; BDBM50238304
Click to Show/Hide
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||||
| Activity |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
3-Substituted indolin-2-one 16c
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
BDBM4897; CHEMBL149073
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
2-[9-(4-Amino-3-methoxyphenyl)-6-oxo-5,11-dihydrobenzo[b][1,4]benzodiazepin-3-yl]-N-(4-morpholin-4-ylphenyl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL395080; BDBM50218700
Click to Show/Hide
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||||
| Activity |
IC50 ~ 50000 nM
|
[34] | |||
| Compound Name |
3-Substituted indolin-2-one 11b
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
SU5402 analog 11b; BDBM4888; CHEMBL435227; SCHEMBL4409949
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
1-[4-(3-Methyl-2H-pyrazolo[3,4-b]pyridin-4-yl)phenyl]-3-pentylurea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4063380; BDBM50238294
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
1-[4-(3-Methyl-2H-pyrazolo[3,4-b]pyridin-4-yl)phenyl]-3-pyridin-2-ylurea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4085962; BDBM50238271
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
8-Chloro-N-phenyl-5H-thiochromeno[4,3-d]pyrimidin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3628816; BDBM50126848
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[28] | |||
| Compound Name |
5-Amino-1-(2-fluorophenyl)-N-(5-(isoxazol-3-ylcarbamoyl)-2-methylphenyl)-1H-pyrazole-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1290746; SCHEMBL14097139; BDBM50331629
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[35] | |||
| Compound Name |
8-Methoxy-N-phenyl-5H-thiochromeno[4,3-d]pyrimidin-2-amine
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3628813; BDBM50126849
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[28] | |||
| Compound Name |
3-[(4-Chlorophenoxy)methyl]-4-methoxybenzamide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1952358; BDBM50364836; ZINC73292950; CH-4594478
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[18] | |||
| Compound Name |
N-[4-[4-Amino-1-[4-(4-methylpiperazin-1-yl)cyclohexyl]pyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl]-2,2-dimethyl-3-phenylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL417006; Pyrazolo[3,4-d]pyrimidine 12; BDBM8804; SCHEMBL6432526; SCHEMBL6432529; SCHEMBL6437272
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[12] | |||
| Compound Name |
6-((4-Methylpiperazin-1-yl)methyl)-3-(3-methylthiophen-2-yl)-1,4-dihydroindeno[1,2-c]pyrazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL212030; BDBM50188291
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[9] | |||
| Compound Name |
4-(4-Amino-6-methylthieno[2,3-d]pyrimidin-5-yl)-N-(3-methylphenyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Thienopyrimidine deriv. 64; 4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}-N-(3-methylphenyl)benzamide; BDBM8814; CHEMBL195054; SCHEMBL4472837
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[26] | |||
| Compound Name |
N-(4-(4-Aminoisoxazolo[5,4-d]pyrimidin-3-yl)phenyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL211379; SCHEMBL3124549; BDBM50188004; N-[4-(4-amino-[1,2]oxazolo[5,4-d]pyrimidin-3-yl)phenyl]benzamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[16] | |||
| Compound Name |
1-[4-(3-Methyl-2H-pyrazolo[3,4-b]pyridin-4-yl)phenyl]-3-naphthalen-1-ylurea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4099718; BDBM50238295
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
1-Cyano-3-(3-methylphenyl)-2-[(5-{6-[(4-methylpiperazin-1-yl)methyl]-1H,4H-indeno[1,2-c]pyrazol-3-yl}thiophen-2-yl)methyl]guanidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL214214; SCHEMBL4823933; SCHEMBL17004662; BDBM50188745
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[27] | |||
| Compound Name |
N-[4-[4-Amino-1-[4-(4-methylpiperazin-1-yl)cyclohexyl]pyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL297363; Pyrazolo[3,4-d]pyrimidine 5; BDBM8797; CHEMBL185440; SCHEMBL6430488; SCHEMBL6430494; BDBM50150879
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
Tert-Butyl-2-{5-(4-hydroxyphenethoxy)-1-{5-[4-(methylthio)phenyl]pentyl}-1H-indole-3-yl}ethyl carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1099339; BDBM50316778
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[20] | |||
| Compound Name |
(1S)-2-(1H-Indol-3-YL)-1-[({5-[(E)-2-pyridin-4-ylvinyl]pyridin-3-YL}oxy)methyl]ethylamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
bispyridinylethylene, 2; pyridine-base inhibitor 1b; CHEMBL383541; SCHEMBL6853457; BDBM15022; trans-bispyridinylethylene analog 2q; Q27096021
Click to Show/Hide
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||||
| Activity |
IC50 ~ 50000 nM
|
[23] | |||
| Compound Name |
N-(4-(4-Amino-7-(3-((1r,4r)-4-aminocyclohexylamino)prop-1-enyl)thieno[3,2-c]pyridin-3-yl)-2-methoxyphenyl)-1-methyl-1H-indole-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL395665; CHEMBL395666; SCHEMBL3616612; SCHEMBL3616621; SCHEMBL5024066; SCHEMBL5024069; BDBM50202735; BDBM50202737
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[29] | |||
| Compound Name |
4-[4-[(E)-3-(4-Fluorophenyl)-3-oxoprop-1-enyl]phenoxy]-N-methylpyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3945365; BDBM50199451
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[36] | |||
| Compound Name |
[4-[4-Amino-1-[4-(4-methylpiperazin-1-yl)cyclohexyl]pyrazolo[3,4-d]pyrimidin-3-yl]phenyl]-phenylmethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL45693; Pyrazolo[3,4-d]pyrimidine 4; BDBM8796; SCHEMBL5785233; SCHEMBL5785235; SCHEMBL5787681; 3-(4-benzoylphenyl)-1-[4-(4-methylpiperazin-1-yl)cyclohexyl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[12] | |||
| Compound Name |
Chembl4202658
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50451033
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[22] | |||
| Compound Name |
4-N-(3-Bromophenyl)-6-[(3,4-dichlorophenyl)methyl]-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956886; BDBM50366078
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[24] | |||
| Compound Name |
Rac-3-(6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)quinolin-3-yl)-N,N-dimethylacrylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL608738; BDBM50306679
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[11] | |||
| Compound Name |
2-(Methylthio)-7-chloro-1-thia-3,4,5,6-tetraaza-1H-indene
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2377495; BDBM50491182
Click to Show/Hide
|
||||
| Activity |
IC50 = 50118.72 nM
|
[37] | |||
| Compound Name |
6-(4-Fluorophenyl)-4-(4-methylbenzyl)-3(2H)-pyridazinone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1488812; Cyto4B8; Oprea1_657781; MLS000850208; HMS2800L15; BDBM50462224; ZINC13657766; CCG-240306; MCULE-9171940002; SMR000456226
Click to Show/Hide
|
||||
| Activity |
IC50 = 51600 nM
|
[38] | |||
| Compound Name |
2-(Dimethylamino)ethyl 4-methoxy-3-[[5-pyrimidin-5-yl-2-(trifluoromethoxy)phenyl]carbamoylamino]benzoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3633276; BDBM50130401
Click to Show/Hide
|
||||
| Activity |
IC50 = 51900 nM
|
[39] | |||
| Compound Name |
6,7,12,16,17-Pentahydroxy-12-(2-oxopropyl)-3,20-dioxapentacyclo[11.7.0.02,10.04,9.014,19]icosa-1(13),2(10),4,6,8,14,16,18-octaen-11-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3236670; BDBM50008833; 2,3,6,8,9-Pentahydroxy-6-(2-oxopropyl)benzo[2,1-b:3,4-b']bisbenzofuran-5(6H)-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 52000 nM
|
[40] | |||
| Compound Name |
N-[(1R)-1-Phenylethyl]-1-(2-phenylethyl)pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CLM-3; CHEMBL3128227
Click to Show/Hide
|
||||
| Activity |
IC50 = 52500 nM
|
[41] | |||
| Compound Name |
2-(Dimethylamino)ethyl 3-[[5-(1H-indol-5-yl)-2-(trifluoromethoxy)phenyl]carbamoylamino]-4-methoxybenzoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3633274; BDBM50130399
Click to Show/Hide
|
||||
| Activity |
IC50 = 53000 nM
|
[39] | |||
| Compound Name |
3,4-Dihydro-1,6-naphthyridine analogue 50
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM6183; CHEMBL190443; ZINC14945363
Click to Show/Hide
|
||||
| Activity |
IC50 = 55000 nM
|
[42] | |||
| Compound Name |
5-(3-Chlorophenyl)-3-(3,4,5-trimethoxyphenyl)-1H-pyrazin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3358994
Click to Show/Hide
|
||||
| Activity |
IC50 = 56000 nM
|
[43] | |||
| Compound Name |
5-[(4-Methylphenyl)thio]-9h-pyrimido[4,5-b]indole-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
AG311; CHEMBL1093100; SCHEMBL1997367; BDBM50314077; 5-(p-tolylthio)-9H-pyrimido[4,5-b]indole-2,4-diamine; 5-(4-methylphenyl)sulfanyl-9H-pyrimido[4,5-b]indole-2,4-diamine
Click to Show/Hide
|
||||
| Activity |
IC50 = 56300 nM
|
[44] | |||
| Compound Name |
4-N-(4-Chlorophenyl)-6-[(2,5-dimethoxyphenyl)methyl]-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1929557; BDBM50360179
Click to Show/Hide
|
||||
| Activity |
IC50 = 56700 nM
|
[45] | |||
| Compound Name |
2-(2-Bromoanilino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL599027; BDBM50308186
Click to Show/Hide
|
||||
| Activity |
IC50 = 57000 nM
|
[3] | |||
| Compound Name |
N-[4-Fluoro-3-(trifluoromethyl)phenyl]-6-(2-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1096415; BDBM50318166
Click to Show/Hide
|
||||
| Activity |
IC50 = 57500 nM
|
[31] | |||
| Compound Name |
2-(6-Amino-9H-purin-9-yl)-1-(pyridin-3-yl)ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL501256; BDBM50268239; 2-(6-Amino-9H-purine-9-yl)-1-(pyridine-3-yl)ethanone
Click to Show/Hide
|
||||
| Activity |
IC50 = 58000 nM
|
[46] | |||
| Compound Name |
4-N-(3-Bromophenyl)-7-[(3,4-dichlorophenyl)methyl]pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956894; BDBM50366085
Click to Show/Hide
|
||||
| Activity |
IC50 = 64500 nM
|
[24] | |||
| Compound Name |
4-N-(3-Bromophenyl)-7-[(4-chlorophenyl)methyl]pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956891; BDBM50366090
Click to Show/Hide
|
||||
| Activity |
IC50 = 65300 nM
|
[24] | |||
| Compound Name |
3,8,15,17,19-Pentazatetracyclo[9.8.0.02,7.013,18]nonadeca-1(19),2(7),3,5,11,13(18)-hexaene-9,14,16-trione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL610512; BDBM50308222; 7,12-Dihydro-5H-pyrido[3,2-b]pyrimido[5'',4'':5,6]pyrido[2,3-d]azepine-6,9,11(10H)-trione
Click to Show/Hide
|
||||
| Activity |
IC50 = 66000 nM
|
[3] | |||
| Compound Name |
Polyozellin
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL458248; SCHEMBL2454411; CTK6A1889; DTXSID30327611; BDBM50269566; NSC670123; NSC-670123; NCI60_024584; Q7226724; 2,3,8,9-tetrahydroxydibenzo[d,d']benzo[1,2-b:4,5-b']difuran-6,12-diyl diacetate
Click to Show/Hide
|
||||
| Activity |
IC50 = 66000 nM
|
[40] | |||
| Compound Name |
2-(((2-Aminophenyl)thio)methyl)quinazolin-4(3H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4239930; Maybridge3_001034; Oprea1_252892; HMS1433O22; ZINC138179; BDBM50462220; CCG-40813; AKOS009318065; MCULE-8016017684; IDI1_012421; SR-01000022288; SR-01000022288-1; SR-01000022288-2; F2551-0038
Click to Show/Hide
|
||||
| Activity |
IC50 = 67000 nM
|
[38] | |||
| Compound Name |
4-(1-Methylbenzimidazol-2-yl)-N-(4-morpholin-4-ylphenyl)pyrimidin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2036728; BDBM50385170
Click to Show/Hide
|
||||
| Activity |
IC50 = 69000 nM
|
[47] | |||
| Compound Name |
Thelephoric acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3236668; Thelephorsaure; CTK8I8421; BDBM50008823; 2,3'-Carbonyl-3,2'-carbonylbis(5,6-dihydroxybenzofuran); 2,3,8,9-Tetrahydroxybenzo[1,2-b:4,5-b']bisbenzofuran-6,12-dione, 9CI
Click to Show/Hide
|
||||
| Activity |
IC50 = 70000 nM
|
[40] | |||
| Compound Name |
4-[(E)-2-(6-Methylimidazo[2,1-b][1,3]thiazol-5-yl)ethenyl]pyrimidin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL444654; BDBM50272588; (E/Z)-4-(2-(6-methylimidazo[2,1-b]thiazol-5-yl)vinyl)pyrimidin-2-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 70000 nM
|
[48] | |||
| Compound Name |
5-Chloro-4-N-(3-methoxyphenyl)-9H-pyrimido[4,5-b]indole-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2337366; BDBM50430567
Click to Show/Hide
|
||||
| Activity |
IC50 = 70100 nM
|
[2] | |||
| Compound Name |
Boletopsin C
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1098561; BDBM50317646
Click to Show/Hide
|
||||
| Activity |
IC50 = 70700 nM
|
[49] | |||
| Compound Name |
US9422297, Aag145-346
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3953855; BDBM242737
Click to Show/Hide
|
||||
| Activity |
IC50 = 73000 nM
|
[50] | |||
| Compound Name |
N-(5-Chloro-1,3-benzodioxol-4-yl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Benzodioxole deriv. 26; BDBM6217; CHEMBL352877; N-(5-chloro-2H-1,3-benzodioxol-4-yl)-7-methoxy-6-[3-(morpholin-4-yl)propoxy]quinazolin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 73820 nM
|
[51] | |||
| Compound Name |
4-[[4-[(5-Chloro-1,3-benzodioxol-4-yl)amino]-6-methoxyquinazolin-7-yl]oxymethyl]pyridine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Chlorobenzodioxole deriv. 29; BDBM6220; CHEMBL354145; SCHEMBL3205132
Click to Show/Hide
|
||||
| Activity |
IC50 = 77000 nM
|
[51] | |||
| Compound Name |
4-[(E)-2-(6-Phenylimidazo[2,1-b][1,3]thiazol-5-yl)vinyl]pyrimidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL505610; SCHEMBL4769544; BDBM50272101; (E/Z)-6-phenyl-5-(2-(pyrimidin-4-yl)vinyl)imidazo[2,1-b]thiazole; 6-phenyl-5-[(E)-2-pyrimidin-4-ylethenyl]imidazo[2,1-b][1,3]thiazole
Click to Show/Hide
|
||||
| Activity |
IC50 = 77000 nM
|
[48] | |||
| Compound Name |
Ethyl 2-[[2-[(4-carbamimidoylphenoxy)methyl]-2,4-dimethyl-3H-1,4-benzoxazin-6-yl]-[(3-fluorophenyl)methyl]amino]-2-oxoacetate;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2216905
Click to Show/Hide
|
||||
| Activity |
IC50 = 80000 nM
|
[52] | |||
| Compound Name |
2-(6-Amino-9H-purine-9-yl)-1-(1H-indole-3-yl)ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL521155; BDBM50268223
Click to Show/Hide
|
||||
| Activity |
IC50 = 81000 nM
|
[46] | |||
| Compound Name |
(4S,6R,12Z)-6-Chloro-18-hydroxy-16-methoxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),12,15,17-tetraene-2,8-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1668416; BDBM50336464
Click to Show/Hide
|
||||
| Activity |
IC50 = 82000 nM
|
[53] | |||
| Compound Name |
2-(1-Methyl-4-phenyl-1H-imidazol-5-yl)[1,3]thiazolo[5,4-d]pyrimidin-7-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1076330; SCHEMBL4798753; ZINC3819905; BDBM50311972; 2-(1-methyl-4-phenyl-1H-imidazol-5-yl)thiazolo[5,4-d]pyrimidin-7-amine; 2-(3-methyl-5-phenylimidazol-4-yl)-[1,3]thiazolo[5,4-d]pyrimidin-7-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 84000 nM
|
[54] | |||
| Compound Name |
1,3-Dimethyl-7-(1-methylbenzimidazol-2-yl)pyrido[2,3-d]pyrimidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2036871; BDBM50385180
Click to Show/Hide
|
||||
| Activity |
IC50 = 85000 nM
|
[47] | |||
| Compound Name |
6-[(2,4-Dichlorophenyl)methyl]-4-N-(3-ethynylphenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1094475; BDBM50318178; N4-(3-Ethynylphenyl)-6-(2,4-dichlorobenzyl)-7Hpyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
||||
| Activity |
IC50 = 85600 nM
|
[55] | |||
| Compound Name |
5-Chloro-4-N-(3-fluorophenyl)-9H-pyrimido[4,5-b]indole-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2337365; BDBM50430568
Click to Show/Hide
|
||||
| Activity |
IC50 = 86100 nM
|
[2] | |||
| Compound Name |
5-Pyridin-4-yl-2-(2,4,6-trichlorophenyl)pyrazol-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2011303; SCHEMBL14839420; BDBM50379219
Click to Show/Hide
|
||||
| Activity |
IC50 = 87000 nM
|
[56] | |||
| Compound Name |
3,8,13,17,18-Pentazatetracyclo[9.7.0.02,7.014,18]octadeca-1(11),2(7),3,5,12,14,16-heptaen-9-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL591896; BDBM50308212; 6,8-Dihydro-7H-pyrazolo[5'',1'':2,3]pyrimido[4,5-d]pyrido[3,2-b]azepin-7-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 87000 nM
|
[3] | |||
| Compound Name |
N-[5-Chloro-4-(4-chloro-2-fluoroanilino)-9H-pyrimido[4,5-b]indol-2-yl]-2,2-dimethylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2337370; BDBM50430563
Click to Show/Hide
|
||||
| Activity |
IC50 = 89100 nM
|
[2] | |||
| Compound Name |
2-Amino-4-(N-methyl-m-bromoanilino)-6-benzyl-pyrrolo[2,3-d]pyrimidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1254199; BDBM50326609
Click to Show/Hide
|
||||
| Activity |
IC50 = 89200 nM
|
[57] | |||
| Compound Name |
N-[4-(3-Chloro-4-fluoroanilino)-6-(2-pyridin-2-ylethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-2,2-dimethylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2335016; BDBM50429670
Click to Show/Hide
|
||||
| Activity |
IC50 = 89300 nM
|
[58] | |||
| Compound Name |
N-(5-Chloro-1,3-benzodioxol-4-yl)-7-(3-morpholin-4-ylpropoxy)quinazolin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Benzodioxole deriv. 25; BDBM6216; CHEMBL422564; N-(5-chloro-2H-1,3-benzodioxol-4-yl)-7-[3-(morpholin-4-yl)propoxy]quinazolin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 91350 nM
|
[51] | |||
| Compound Name |
Chembl4237913
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Maybridge4_001303; Oprea1_002513; HMS1524L05; BDBM50462225; CCG-43114; MCULE-1847675099; IDI1_031885; SR-01000633061-1; BRD-A52235082-001-01-5
Click to Show/Hide
|
||||
| Activity |
IC50 = 92700 nM
|
[38] | |||
| Compound Name |
(4S,6R)-6-Chloro-18-hydroxy-16-methoxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),15,17-triene-2,8-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1668413; BDBM50336465
Click to Show/Hide
|
||||
| Activity |
IC50 = 93000 nM
|
[53] | |||
| Compound Name |
N-(2-Aminopyrimidin-4-yl)-1-methyl-4-phenyl-1H-imidazole-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL500152; BDBM50272267
Click to Show/Hide
|
||||
| Activity |
IC50 = 98000 nM
|
[48] | |||
| Compound Name |
4-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2435077; CHEMBL1242032; 4-(4-amino-1-isopropyl-1h-pyrazolo[3,4-d]pyrimidin-3-yl)benzenesulfonamide; 4-(4-amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)benzenesulfonamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 98800 nM
|
[1] | |||
| Compound Name |
1-(4-Methoxyphenyl)-3-(3-phenylpyrido[3,4-b]pyrazin-8-yl)urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3781939
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[59] | |||
| Compound Name |
N-(3-Methoxyphenyl)-3-(4-piperidin-1-ylphenyl)pyrido[3,4-b]pyrazin-8-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3782023
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[59] | |||
| Compound Name |
1-Tert-butyl-3-(3,4-dimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL6055041; CHEMBL1242379; 1-tert-butyl-3-(3,4-dimethoxyphenyl)pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
N-(4-Cyanophenyl)-4-(6,7-dimethoxyquinazolin-4-yl)piperazine-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL106966; SCHEMBL2921461; BDBM50115297; 4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-carboxylic acid (4-cyano-phenyl)-amide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[60] | |||
| Compound Name |
N-(1-Phenylethyl)-4-(2-(6-phenylimidazo[2,1-b]thiazol-5-yl)vinyl)pyrimidin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL502803; SCHEMBL4769687; SCHEMBL4769691; BDBM50272070; N-(1-phenylethyl)-4-[(E)-2-(6-phenylimidazo[2,1-b][1,3]thiazol-5-yl)ethenyl]pyrimidin-2-amine; N-(1-phenylethyl)-4-[(E)-2-(6-phenylimidazo[2,1-b][1,3]thiazol-5-yl)vinyl]pyrimidin-2-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
(8S,16S)-3,16-Dihydroxy-9,10-seco-1,3,5(10)-cholestatrien-9-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL456294; Calicoferol I; USFQLAVWHQCNDG-AYEIPMSGSA-; BDBM50358248; LMST03020180
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[61] | |||
| Compound Name |
3-(3-Ethoxy-4-methoxyphenyl)-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242752
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
3-Phenyl-N-(4-piperidin-1-ylphenyl)pyrido[3,4-b]pyrazin-7-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3780571
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[59] | |||
| Compound Name |
N-(3-Methoxyphenyl)-2-phenylpyrido[3,4-b]pyrazin-7-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3781159
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[59] | |||
| Compound Name |
4-(6,7-Dimethoxy-4-quinazolinyl)-N-(4-nitrophenyl)-1-piperazinecarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL99743; SCHEMBL842459; BDBM50115295; KN1022; 4-(6,7-dimethoxyquinazolin-4-yl)-N-(4-nitrophenyl)piperazine-1-carboxamide; 4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-carboxylic acid (4-nitro-phenyl)-amide; 4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-carboxylic acid (4-nitro-phenyl)-amide(KN1022)
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[60] | |||
| Compound Name |
1-[7-(3,4-Dimethoxyphenyl)-1,5-naphthyridin-2-yl]-3-ethylurea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3318024; SCHEMBL1932174; BDBM50050850
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[62] | |||
| Compound Name |
3,8,13,15,17,18-Hexazatetracyclo[9.7.0.02,7.014,18]octadeca-1(11),2(7),3,5,12,14,16-heptaen-9-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL608427; BDBM50308215; 6,8-Dihydro-7H-pyrido[3,2-b][1,2,4]triazolo[5'',1'':2,3]pyrimido[4,5-d]azepin-7-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
2-Chloro-6,7-dimethoxy-N-(4-(methylsulfonyl)phenyl)quinazolin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3098315; BDBM50444628; ZINC103226716; DA-26425; FT-0723401; 2-chloro-6,7-dimethoxy-N-(4-methylsulfonylphenyl)quinazolin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[63] | |||
| Compound Name |
4-(2-(1-Methyl-4-phenyl-1H-imidazol-5-yl)cyclopropyl)pyrimidin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL526880; BDBM50272308
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
3-(2,3-Dihydrobenzofuran-5-yl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL3602713; CHEMBL1241587; 3-(2,3-dihydro-1-benzofuran-5-yl)-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
1-[7-(1-Methylpyrazol-4-yl)-1,5-naphthyridin-2-yl]-3-(2-phenylethyl)urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3318030; SCHEMBL1933387; BDBM50050852
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[62] | |||
| Compound Name |
3-(4-Fluoro-3-methoxyphenyl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL3605089; CHEMBL1241483; 3-(4-fluoro-3-methoxyphenyl)-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
3-Oxoisoindoline-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
1H-Isoindole-4-carboxamide, 2,3-dihydro-3-oxo-; CHEMBL505167; 3-Oxo-2,3-dihydro-1H-isoindole-4-carboxamide; SCHEMBL1859905; CTK8C3072; DTXSID40659556; 5876AC; ANW-69632; BDBM50264616; MFCD13177837; ZINC40379255; AKOS016006377; 3-oxo-1,2-dihydroisoindole-4-carboxamide; L-1816; 1H-Isoindole-4-carboxamide,2,3-dihydro-3-oxo-; 3-oxo-2,3-dihydro-1H-isoindole-4-carboxylic acid amide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[64] | |||
| Compound Name |
(S)-3-(4-Amino-3-(3,4-dimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-2-methylpropan-1-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242380
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
N-Benzyl-4-(6,7-dimethoxyquinazolin-4-yl)piperazine-1-carbothioamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL319894; SCHEMBL2919724; BDBM50118831; N-Benzyl-4-(6,7-dimethoxyquinazoline-4-yl)piperazine-1-carbothioamide; 4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-carbothioic acid benzylamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[65] | |||
| Compound Name |
1-Isopropyl-3-(3-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2467650; CHEMBL1242029; 3-(3-methoxyphenyl)-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
1-Isopropyl-3-(pyrimidin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL3616915; CHEMBL1241391; US9765037, Compound 18; BDBM340891; 1-propan-2-yl-3-pyrimidin-5-ylpyrazolo[3,4-d]pyrimidin-4-amine; 1-isopropyl-3-(pyrimidin-5-yl)-1H-pyrazolo[3,4- d]pyrimidin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
4-Amino-6-(4-(benzyloxy)-3-chlorophenylamino)-N-(2-methoxyethyl)pyrimidine-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL517745; SCHEMBL13873522; BDBM50245409
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[66] | |||
| Compound Name |
US9296747, Example 4
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3912751; SCHEMBL17620622; BDBM214709; N-phenyl-6-(pyridin-3-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[67] | |||
| Compound Name |
4-Amino-6-(4-(benzyloxy)-3-chlorophenylamino)-N-phenylpyrimidine-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL461114; SCHEMBL3974260; BDBM50245363; 4-amino-6-(3-chloro-4-phenylmethoxyanilino)-N-phenylpyrimidine-5-carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[66] | |||
| Compound Name |
1-Isopropyl-3-(2-methylquinolin-7-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242209
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
1-(3-Methoxyphenyl)-3-(3-phenylpyrido[3,4-b]pyrazin-8-yl)urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3780358
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[59] | |||
| Compound Name |
4-Amino-6-(4-(benzyloxy)-3-chlorophenylamino)-N-(2-(piperidin-1-yl)ethyl)pyrimidine-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL462343; SCHEMBL13873521; BDBM50245364
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[66] | |||
| Compound Name |
6-[2-[2-(Dimethylamino)ethylamino]ethylamino]-2-ethylbenzo[de]isoquinoline-1,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2407517; BDBM50437562
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[68] | |||
| Compound Name |
6-[2-[2-(Dimethylamino)ethylamino]ethylamino]-2-hexadecylbenzo[de]isoquinoline-1,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2407635; BDBM50437557
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[68] | |||
| Compound Name |
2-Amino-N-(1-methyl-4-phenyl-1H-imidazol-5-yl)pyrimidine-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL525048; BDBM50272268
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
1-(4-(6-Amino-5-((methoxyimino)methyl)pyrimidin-4-yloxy)-3-bromophenyl)-3-methylurea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1681963; BDBM50338233
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[69] | |||
| Compound Name |
3-(2-Chloroquinolin-3-yl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242663
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
(2-(5-(Isoquinolin-4-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl)-1H-benzo[d]imidazol-4-yl)methanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL248890; SCHEMBL4037729; BDBM50214102; [2-(5-isoquinolin-4-yl-1H-pyrazolo[3,4-b]pyridin-3-yl)-1H-benzoimidazol-4-yl]-methanol; [2-(5-isoquinolin-4-yl-1,2-dihydropyrazolo[3,4-b]pyridin-3-ylidene)benzimidazol-4-yl]methanol
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[70] | |||
| Compound Name |
5-(4-Amino-1-((5-methyl-2-phenyl-2H-1,2,3-triazol-4-yl)methyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-fluorophenol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242845
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
N-(4-Morpholin-4-ylphenyl)-2-phenylpyrido[3,4-b]pyrazin-7-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3780543
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[59] | |||
| Compound Name |
4-[(2-Chloro-6,7-dimethoxyquinazolin-4-yl)amino]benzenesulfonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3098323; BDBM50444622
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[63] | |||
| Compound Name |
Ethyl 5-amino-3-pyridin-4-yl-1-(2,4,6-trichlorophenyl)pyrazole-4-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2011300; SCHEMBL14833707; BDBM50379221; Ethyl 5-amino-3-(pyridin-4-yl)-1-(2,4,6-trichlorophenyl)-1H-pyrazole-4-carb-oxylate
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[56] | |||
| Compound Name |
1-Tert-butyl-3-[7-(3,4-dimethoxyphenyl)-1,5-naphthyridin-2-yl]urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3318025; SCHEMBL1932951; BDBM50050849
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[62] | |||
| Compound Name |
N-(4-Benzyloxy-3-chloro-phenyl)-5-[5-(2-morpholin-4-yl-ethyl)-[1,3,4]oxadiazol-2-yl]-pyrimidine-4,6-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL472545; SCHEMBL1096374; BDBM50245472
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[66] | |||
| Compound Name |
N-(3-Ethynylphenyl)-2-phenylpyrido[3,4-b]pyrazin-5-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3780350
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[59] | |||
| Compound Name |
Methyl 7-[4-({[(2-fluoro-5-methylphenyl)amino]carbonyl}amino)phenyl]thieno[3,2-b]pyridine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL1459587; CHEMBL3897675; BDBM228524; US9340555, F4; methyl 7-[4-[(2-fluoro-5-methylphenyl)carbamoylamino]phenyl]thieno[3,2-b]pyridine-2-carboxylate
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[71] | |||
| Compound Name |
4-(4-Amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)-2-chlorobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1241862
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
N-(5-Ethylsulfonyl-2-methoxyphenyl)-1-(3-pyridin-3-ylphenyl)triazol-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3633695; BDBM50130407
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[72] | |||
| Compound Name |
(E/Z)-4-(2-(3-Phenylthiophen-2-yl)vinyl)pyrimidin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL500930; BDBM50272162
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
1-Isopropyl-3-(3,4,5-trimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242660; SCHEMBL3602391; BDBM50345734; 1-propan-2-yl-3-(3,4,5-trimethoxyphenyl)pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
(E/Z)-N-Phenyl-4-(2-(6-phenylimidazo[2,1-b]thiazol-5-yl)vinyl)pyrimidin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL526932; SCHEMBL4775072; BDBM50272071; N-phenyl-4-[(E)-2-(6-phenylimidazo[2,1-b][1,3]thiazol-5-yl)ethenyl]pyrimidin-2-amine; N-Phenyl-4[(E)-2-(6-phenylimidazo[2,1-b][1,3]thiazol-5-yl)vinyl]pyrimidin-2-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
1-(4-Methoxyphenyl)-3-(2-thieno[3,2-b]pyridin-7-ylsulfanylphenyl)urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3612225
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[73] | |||
| Compound Name |
4-N-(3-Methyl-5-phenylimidazol-4-yl)pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL525047; BDBM50272266; (E/Z)-N4-(1-methyl-4-phenyl-1H-imidazol-5-yl)pyrimidine-2,4-diamine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
1-Isopropyl-3-(3,4-dimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242290; MMV675993; SCHEMBL2469676; BDBM50345733; 3-(3,4-dimethoxyphenyl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine; 3-(3,4-dimethoxyphenyl)-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
1-Ethyl-3-(2-phenylpyrido[3,4-b]pyrazin-5-yl)urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3780985
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[59] | |||
| Compound Name |
(3-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl)methanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL3607897; CHEMBL1241582; (3-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl) methanol; [3-(4-amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)phenyl]methanol
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
7-[4-({[(2-Fluoro-5-methylphenyl)amino]carbonyl}amino)phenyl]thieno[3,2-b]pyridine-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL1460384; CHEMBL3911858; BDBM228525; US9340555, F5; 7-[4-[(2-fluoro-5-methylphenyl)carbamoylamino]phenyl]thieno[3,2-b]pyridine-2-carboxylic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[71] | |||
| Compound Name |
Tert-butyl 2-(2-methyl-3-oxoisoindolin-4-yl)-1H-pyrrole-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL491243; SCHEMBL5332117; BDBM50264549; tert-butyl 2-(2-methyl-3-oxo-1H-isoindol-4-yl)pyrrole-1-carboxylate; 2-(2-methyl-3-oxo-2,3-dihydro-1H-isoindol-4-yl)-pyrrole-1-carboxylic acid tert-butyl ester
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[64] | |||
| Compound Name |
(4S,6R,12E)-6-Bromo-18-hydroxy-16-methoxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),12,15,17-tetraene-2,8-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1668414; BDBM50336462
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[53] | |||
| Compound Name |
6-[2-[2-(Dimethylamino)ethylamino]ethylamino]-2-methylbenzo[de]isoquinoline-1,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2407516; BDBM50437563
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[68] | |||
| Compound Name |
4-(6-Amino-5-((methoxyimino)methyl)pyrimidin-4-yloxy)phenyl ethylcarbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1681959; SCHEMBL2453863; BDBM50338229
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[69] | |||
| Compound Name |
1-(3-Methoxyphenyl)-3-(2-phenylpyrido[3,4-b]pyrazin-5-yl)urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3780768
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[59] | |||
| Compound Name |
1-(4-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl)ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2466148; CHEMBL1241773; 1-[4-(4-amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)phenyl]ethanone
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
3-(Benzo[c][1,2,5]oxadiazol-6-yl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL3610515; CHEMBL1241492; 3-(2,1,3-benzoxadiazol-5-yl)-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
6-(4-Amino-1-cyclopentyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)quinolin-2(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1241864
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-5-[2-[3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl]ethynyl]-6-methylpyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1934626; BDBM50360453
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[74] | |||
| Compound Name |
3-(H-Imidazo[1,2-a]pyridin-7-yl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242665
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
Methyl 3-(piperidin-1-yl)-1H-thieno[2,3-c]pyrazole-5-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL200348; BDBM50175233
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[75] | |||
| Compound Name |
4-Amino-6-(4-(benzyloxy)-3-chlorophenylamino)-N-(4-methoxyphenyl)pyrimidine-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL472383; SCHEMBL13873526; BDBM50245443
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[66] | |||
| Compound Name |
Tert-butyl 6-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)quinolin-4-ylcarbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242033
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
N-(4-Bromophenyl)-4-(6,7-dimethoxyquinazolin-4-yl)piperazine-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL323336; SCHEMBL2918427; BDBM50115298; N-(4-bromophenyl)-4-(6,7-dimethoxy-4-quinazolinyl)-1-piperazinecarboxamide; 4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-carboxylic acid (4-bromo-phenyl)-amide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[60] | |||
| Compound Name |
4-[(2-Chloroquinazolin-4-yl)amino]-N,N-dimethylbenzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3098314; BDBM50444625
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[63] | |||
| Compound Name |
4-(3-(4-(Methoxymethyl)-1H-benzo[d]imidazol-2-yl)-1-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)isoquinoline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL251740; SCHEMBL4035835; BDBM50214101
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[70] | |||
| Compound Name |
4-Amino-6-(4-(benzyloxy)-3-chlorophenylamino)-N-(2-morpholinoethyl)pyrimidine-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL518646; SCHEMBL13873523; BDBM50245407
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[66] | |||
| Compound Name |
3-Fluorobenzyl 4-amino-6-(4-(benzyloxy)-3-chlorophenylamino)pyrimidine-5-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL472382; SCHEMBL3977223; BDBM50245442; (3-fluorophenyl)methyl 4-amino-6-(3-chloro-4-phenylmethoxyanilino)pyrimidine-5-carboxylate
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[66] | |||
| Compound Name |
4,8,15,17,19-Pentazatetracyclo[9.8.0.02,7.013,18]nonadeca-1(19),2(7),3,5,11,13(18)-hexaene-9,14,16-trione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL606119; BDBM50308220; 7,12-Dihydro-5H-pyrido[4,3-b]pyrimido[5'',4'':5,6]pyrido[2,3-d]azepine-6,9,11(10H)-trione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
8,15,17,19-Tetrazatetracyclo[9.8.0.02,7.013,18]nonadeca-1(19),2,4,6,11,13(18)-hexaene-9,14,16-trione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL597207; BDBM50308216; 7,12-Dihydro-5H-pyrimido[5'',4'':5,6]pyrido[3,2-d][1]benzazepine-6,9,11(10H)-trione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
1-Phenyl-3-(2-thieno[3,2-b]pyridin-7-ylsulfanylphenyl)urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3612224
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[73] | |||
| Compound Name |
1-Cyclohexyl-3-(4-ethoxy-3-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242659
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
N-Phenyl-3-(4-piperidin-1-ylphenyl)pyrido[3,4-b]pyrazin-8-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3781538
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[59] | |||
| Compound Name |
1-Isopropyl-3-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL3610353; CHEMBL1241390; US9765037, Compound 16; BDBM340889; 1-propan-2-yl-3-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-amine; 1-isopropyl-3-(pyridin-3-yl)-1H-pyrazolo[3,4- d]pyrimidin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
Calicoferol C
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL515982; BDBM50358249
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[61] | |||
| Compound Name |
1-Allyl-3-(4-ethoxy-3-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242569
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
4-Amino-6-(4-(benzyloxy)-3-chlorophenylamino)-N''-(3-morpholinopropanoyl)pyrimidine-5-carbohydrazide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL472544; SCHEMBL1096489; BDBM50245471
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[66] | |||
| Compound Name |
2-Butyl-6-[2-[2-(dimethylamino)ethylamino]ethylamino]benzo[de]isoquinoline-1,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2407518; BDBM50437561
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[68] | |||
| Compound Name |
1-N-(6-Chloro-[1,3]dioxolo[4,5-g]quinazolin-8-yl)-4-N,4-N-dimethylbenzene-1,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3098320; BDBM50444623
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[63] | |||
| Compound Name |
N-[3-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-phenyl]-methanesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2432675; CHEMBL1241948; N-[3-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-phenyl]methanesulfonamide; N-[3-(4-amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)phenyl]methanesulfonamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
4-[(2-Chloro-6,7-dimethoxyquinazolin-4-yl)amino]benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3098324; BDBM50444621
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[63] | |||
| Compound Name |
pi-103 (Hydrochloride)
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
PI 103 HYDROCHLORIDE; PI-103 Hydrochloride; CHEMBL538346; PI103 hydrochloride; PubChem22442; C19H16N4O3.ClH; C19H16N4O3.HCl; DTXSID30587490; 3971AH; ABP000093; HY-10115A; LT0082; AKOS024457341; CS-0760; SB10966; 3-(4-Morpholinopyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl)phenol hydrochloride; PI 103 hydrochloride;PI103 hydrochloride; W-5452; PI-103 - CAS 371935-74-9
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
Calicoferol B
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL464351; BDBM50358250
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[61] | |||
| Compound Name |
3-(3-(4-(Methoxymethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazolo[3,4-b]pyridin-5-yl)quinoline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL249095; SCHEMBL4037124; BDBM50214103
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[70] | |||
| Compound Name |
4-Amino-6-(4-(benzyloxy)-3-chlorophenylamino)-N,N-diethylpyrimidine-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL452727; SCHEMBL4090152; BDBM50245410; 4-amino-6-(3-chloro-4-phenylmethoxyanilino)-N,N-diethylpyrimidine-5-carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[66] | |||
| Compound Name |
15,17-Dimethyl-8,15,17,19-tetrazatetracyclo[9.8.0.02,7.013,18]nonadeca-1(19),2,4,6,11,13(18)-hexaene-9,14,16-trione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL603481; BDBM50308217; 10,12-Dimethyl-7,12-dihydro-5H-pyrimido[5'',4'':5,6]pyrido[3,2-d][1]benzazepine-6,9,11-(10H)-trione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Methyl 3-(phenylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL200796; BDBM50175251
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[75] | |||
| Compound Name |
3-Oxoisoindoline-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
3-OXO-2,3-DIHYDRO-1H-ISOINDOLE-4-CARBOXYLIC ACID; CHEMBL505379; MFCD11506114; 1H-Isoindole-4-carboxylic acid, 2,3-dihydro-3-oxo-; SCHEMBL5338831; CTK8B7220; DTXSID60659558; 3-Oxo-4-isoindolinecarboxylic acid; 5877AC; ANW-56758; BDBM50264659; ZINC40834475; AKOS006323136; DS-3664; SB40069; AK101028; SY235534; DB-079603; CS-0062203; FT-0712220; 3-oxo-1,2-dihydroisoindole-4-carboxylic acid; L-1815
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[64] | |||
| Compound Name |
6-(4-Amino-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-4H-chromen-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242117
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
Anilinoquinazoline deriv. 31
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM4648; CHEMBL151948; N-[4-(4-Chloro-2-fluoroanilino)-6-methoxy-7-quinazolinyl]-2-methoxyacetamide hydrochloride; N-{4-[(4-chloro-2-fluorophenyl)amino]-6-methoxyquinazolin-7-yl}-2-methoxyacetamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[76] | |||
| Compound Name |
5-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)pyridine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2465891; CHEMBL1241772; 5-(4-amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)pyridine-2-carbonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
N-(3-Methoxyphenyl)-2-phenylpyrido[3,4-b]pyrazin-5-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3781584
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[59] | |||
| Compound Name |
15,17-Dimethyl-4,8,15,17,19-pentazatetracyclo[9.8.0.02,7.013,18]nonadeca-1(19),2(7),3,5,11,13(18)-hexaene-9,14,16-trione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL599055; BDBM50308221
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
4-(2-(1-Methyl-4-phenyl-1H-imidazol-5-ylamino)ethyl)pyrimidin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL499863; BDBM50272307
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
5-Methoxy-15,17-dimethyl-8,15,17,19-tetrazatetracyclo[9.8.0.02,7.013,18]nonadeca-1(19),2(7),3,5,11,13(18)-hexaene-9,14,16-trione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL596598; BDBM50308219
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
US9296747, Example 2
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3985924; SCHEMBL17620625; BDBM214707
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[67] | |||
| Compound Name |
(E/Z)-4-(2-(2-Phenylthiophen-3-yl)vinyl)pyrimidin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL499883; BDBM50272214
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
4-[[6-Amino-4-butoxy-5-(2,6-difluorobenzoyl)pyridin-2-yl]amino]benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
3-Acyl-2,6-diaminopyridine deriv. 11; BDBM6913; SCHEMBL4551602; CHEMBL2113092; 4-({6-amino-4-butoxy-5-[(2,6-difluorophenyl)carbonyl]pyridin-2-yl}amino)benzene-1-sulfonamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[77] | |||
| Compound Name |
3-Acyl-2,6-diaminopyridine deriv. 2p
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM6896; CHEMBL193456; 4-({6-amino-5-[(2,6-difluorophenyl)carbonyl]pyridin-2-yl}amino)-N,N-dimethylbenzene-1-sulfonamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[77] | |||
| Compound Name |
1-Benzyl-3-[7-(1-methylpyrazol-4-yl)-1,5-naphthyridin-2-yl]urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3318029; SCHEMBL1933048; BDBM50050853
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[62] | |||
| Compound Name |
6-Chloro-N-(4-methylsulfonylphenyl)-[1,3]dioxolo[4,5-g]quinazolin-8-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3098316; BDBM50444624
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[63] | |||
| Compound Name |
4-[(6-Chloro-[1,3]dioxolo[4,5-g]quinazolin-8-yl)amino]-N-(1,3-thiazol-2-yl)benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3098311; BDBM50444626
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[63] | |||
| Compound Name |
3-(3-(Benzyloxy)-4-methyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242025
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
4-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-fluorobenzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL3616930; CHEMBL1241771; ZINC43465534; 4-(4-amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)-2-fluorobenzonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
Methyl 3-oxoisoindoline-4-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
3-OXO-2,3-DIHYDRO-1H-ISOINDOLE-4-CARBOXYLIC ACID METHYL ESTER; CHEMBL473040; 1H-Isoindole-4-carboxylic acid, 2,3-dihydro-3-oxo-, methyl ester; Methyl 3-oxo-2,3-dihydro-1H-isoindole-4-carboxylate; SCHEMBL5333318; CTK8B8670; DTXSID00659557; 5875AC; ANW-61005; BDBM50264658; MFCD11506113; ZINC40411061; AKOS006323135; SB40068; DB-079602; AM20120450; FT-0736019; L-1817; methyl 3-oxo-1,2-dihydroisoindole-4-carboxylate; 2,3-Dihydro-3-oxo-1H-isoindole-4-carboxylic acid methyl ester
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[64] | |||
| Compound Name |
(3S,5E)-1-Methyl-3-(pyridin-2-ylmethyl)-5-(pyridin-2-ylmethylidene)piperidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2338335; BDBM50431025
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[78] | |||
| Compound Name |
1-(2-Chlorophenyl)-3-(alpha,alpha,alpha-trifluoro-M-tolyl)urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2069624; SCHEMBL10991763; ZINC2161684; BDBM50389605; AKOS024332664; MCULE-4036035781
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[32] | |||
| Compound Name |
Tert-butyl N-[(2R)-3-methyl-1-oxo-1-[[4-[3-(trifluoromethyl)anilino]quinazolin-6-yl]amino]butan-2-yl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4092491; BDBM50237567
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[79] | |||
| Compound Name |
4-(6-Amino-5-((methoxyimino)methyl)pyrimidin-4-yloxy)-N-methylbenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1681957; SCHEMBL12303579; BDBM50338227
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[69] | |||
| Compound Name |
6-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)quinolin-2(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1241863
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
3-(4-Ethoxy-3-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242471; SCHEMBL16665685
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
4-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-methoxyphenol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242112
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
N-(3-Chloro-4-fluorophenyl)-3-phenylpyrido[3,4-b]pyrazin-8-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3780151
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[59] | |||
| Compound Name |
2-[(E)-2-(6-Phenylimidazo[2,1-b][1,3]thiazol-5-yl)ethenyl]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL527110; BDBM50272158; (E/Z)-2-(2-(6-phenylimidazo[2,1-b]thiazol-5-yl)vinyl)pyrimidin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
1-[3-[7-(4-Amino-5-fluoropyrimidin-2-yl)imidazo[1,2-a]pyridin-3-yl]-5-cyclopentyloxyphenyl]-3-(2,2,2-trifluoroethyl)urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3694673; SCHEMBL11925885; BDBM128687; US8796244, 281
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[80] | |||
| Compound Name |
15,17-Dimethyl-3,8,15,17,19-pentazatetracyclo[9.8.0.02,7.013,18]nonadeca-1(19),2(7),3,5,11,13(18)-hexaene-9,14,16-trione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL599056; BDBM50308223
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
6-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-4H-chromen-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242118
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
1-(4-Cyanophenyl)-3-(2-thieno[3,2-b]pyridin-7-ylsulfanylphenyl)urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3612226
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[73] | |||
| Compound Name |
(3R,5E)-1-Methyl-3-(pyridin-2-ylmethyl)-5-(pyridin-2-ylmethylidene)piperidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2338334; BDBM50431026
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[78] | |||
| Compound Name |
N-(4-Methoxyphenethyl)-4-amino-6-(4-(benzyloxy)-3-chlorophenylamino)pyrimidine-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL461115; SCHEMBL13873524; BDBM50245408
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[66] | |||
| Compound Name |
1-[3-(4-Amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)phenyl]ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1241946; SCHEMBL2469922; BDBM50345736
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
4-[[6-Amino-5-(2,6-difluorobenzoyl)pyridin-2-yl]amino]benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
3-Acyl-2,6-diaminopyridine deriv. 2r; BDBM6898; CHEMBL193643; SCHEMBL4419524; 4-({6-amino-5-[(2,6-difluorophenyl)carbonyl]pyridin-2-yl}amino)benzene-1-sulfonamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[77] | |||
| Compound Name |
[4-[4-(5-Ethylsulfonyl-2-methoxyanilino)triazol-1-yl]-2-naphthalen-1-ylphenyl]urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3633691; BDBM50130409
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[72] | |||
| Compound Name |
4-(3-Chlorobenzamido)-3-methyl-1H-thieno[2,3-c]pyrazole-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL199657; BDBM50175253
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[75] | |||
| Compound Name |
N-(4-Methoxyphenyl)-2-phenylpyrido[3,4-b]pyrazin-5-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3781566
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[59] | |||
| Compound Name |
1-Tert-butyl-3-[7-(1-methylpyrazol-4-yl)-1,5-naphthyridin-2-yl]urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3318027; SCHEMBL1932932; BDBM50050847
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[62] | |||
| Compound Name |
N4-((1-Methyl-4-phenyl-1H-imidazol-5-yl)methyl)pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL450886; BDBM50272269
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
1-[7-(1-Methylpyrazol-4-yl)-1,5-naphthyridin-2-yl]-3-phenylurea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3318028; SCHEMBL1932302; BDBM50050854
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[62] | |||
| Compound Name |
5-Methoxy-8,13,15,17,18-pentazatetracyclo[9.7.0.02,7.014,18]octadeca-1(11),2(7),3,5,12,14,16-heptaen-9-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL597005; BDBM50308214; 10-Methoxy-6,8-dihydro-7H-[1,2,4]triazolo[5'',1'':2,3]pyrimido[5,4-d][1]benzazepin-7-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
5-Methoxy-8,15,17,19-tetrazatetracyclo[9.8.0.02,7.013,18]nonadeca-1(19),2(7),3,5,11,13(18)-hexaene-9,14,16-trione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL599666; BDBM50308218; 3-Methoxy-7,12-dihydro-5H-pyrimido[5'',4'':5,6]pyrido[3,2-d][1]benzazepine-6,9,11-(10H)-trione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
N-(4-Ethoxyphenyl)-4-(1-methylbenzimidazol-2-yl)pyrimidin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2036867; BDBM50385176
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[47] | |||
| Compound Name |
4-(4-Chlorobenzamido)-3-methyl-1H-thieno[2,3-c]pyrazole-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL199658; BDBM50175244
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[75] | |||
| Compound Name |
2-(5-Isoquinolin-4-yl-1H-pyrazolo[3,4-b]pyridin-3-yl)-1H-benzoimidazole-4-carboxylic acid methyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL399042; SCHEMBL4037517; BDBM50214104; methyl 2-(5-(isoquinolin-4-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl)-1H-benzo[d]imidazole-4-carboxylate
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[70] | |||
| Compound Name |
1-Ethyl-3-[7-(4-methoxyphenyl)-1,5-naphthyridin-2-yl]urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3318023; SCHEMBL1932961; BDBM50050851
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[62] | |||
| Compound Name |
5-(4-Amino-1-((4-phenyloxazol-5-yl)methyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-fluorophenol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1241482
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
1-Tert-butyl-3-[7-(4-hydroxy-3-methoxyphenyl)-1,5-naphthyridin-2-yl]urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3318026; SCHEMBL1933008; BDBM50050848
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[62] | |||
| Compound Name |
5-[(E)-2-(2-Chloropyrimidin-4-yl)vinyl]-6-phenylimidazo[2,1-b][1,3]thiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL501444; SCHEMBL4770215; BDBM50272074; (E/Z)-5-(2-(2-chloropyrimidin-4-yl)vinyl)-6-phenylimidazo[2,1-b]thiazole; 5-[(E)-2-(2-chloropyrimidin-4-yl)ethenyl]-6-phenylimidazo[2,1-b][1,3]thiazole
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
6-[2-[2-(Dimethylamino)ethylamino]ethylamino]-2-hexylbenzo[de]isoquinoline-1,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2407519; BDBM50437560
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[68] | |||
| Compound Name |
(E/Z)-4-(2-(4-Phenyl-1H-pyrazol-5-yl)vinyl)pyrimidin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL500929; BDBM50272161
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
7-((1H-1,2,4-Triazol-1-yl)methyl)-3-(thiophen-3-yl)-1,4-dihydroindeno[1,2-c]pyrazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL213014; SCHEMBL4823887; BDBM50188286; 3-thiophen-3-yl-7-(1,2,4-triazol-1-ylmethyl)-1,4-dihydroindeno[1,2-c]pyrazole
Click to Show/Hide
|
||||
| Activity |
IC50 = 108000 nM
|
[9] | |||
| Compound Name |
N-(3-Bromophenyl)-6-(2-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1094423; BDBM50318162
Click to Show/Hide
|
||||
| Activity |
IC50 = 112300 nM
|
[31] | |||
| Compound Name |
N4-(3-Fluoro-4-trifluoromethylphenyl)-6-(2,4-dichlorobenzyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1094808; BDBM50318179
Click to Show/Hide
|
||||
| Activity |
IC50 = 113100 nM
|
[55] | |||
| Compound Name |
4-N-(3-Bromophenyl)-7-[(2-methylphenyl)methyl]pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956889; BDBM50366089
Click to Show/Hide
|
||||
| Activity |
IC50 = 113400 nM
|
[24] | |||
| Compound Name |
2-Amino-4-(m-bromoanilino)-6-(2-methylbenzyl)-7-methyl-pyrrolo[2,3-d]pyrimidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1254364; BDBM50326613
Click to Show/Hide
|
||||
| Activity |
IC50 = 116300 nM
|
[57] | |||
| Compound Name |
5-Chloro-4-N-phenyl-9H-pyrimido[4,5-b]indole-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2337374; BDBM50430572
Click to Show/Hide
|
||||
| Activity |
IC50 = 123800 nM
|
[2] | |||
| Compound Name |
4-N-[4-Fluoro-3-(trifluoromethyl)phenyl]-6-(2-pyridin-2-ylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2335014; BDBM50429671
Click to Show/Hide
|
||||
| Activity |
IC50 = 124500 nM
|
[58] | |||
| Compound Name |
N-[4-(3-Ethynylanilino)-6-(2-pyridin-2-ylethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-2,2-dimethylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2335017; BDBM50429677
Click to Show/Hide
|
||||
| Activity |
IC50 = 125600 nM
|
[58] | |||
| Compound Name |
5-(1-(2,5-Dichlorobenzyl)-1H-1,2,3-triazol-4-yl)-1H-indazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1682355; SCHEMBL3672631; BDBM50337329; 5-[1-[(2,5-dichlorophenyl)methyl]triazol-4-yl]-1H-indazole
Click to Show/Hide
|
||||
| Activity |
Ki = 126500 nM
|
[81] | |||
| Compound Name |
N4-(3-Chloro-4-fluorophenyl)-6-(2-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL504416; BDBM50271804
Click to Show/Hide
|
||||
| Activity |
IC50 = 132100 nM
|
[14] | |||
| Compound Name |
N4-(3-Bromo-4-fluorophenyl)-6-phenethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL483108; BDBM50271803; N4-(3-bromo-4-fluorophenyl)-6-(2-phenylethyl)-7Hpyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
||||
| Activity |
IC50 = 132100 nM
|
[31] | |||
| Compound Name |
US9422297, Aag145-340
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3976755; BDBM242733
Click to Show/Hide
|
||||
| Activity |
IC50 = 132900 nM
|
[50] | |||
| Compound Name |
7-(2-(4-Methylpiperazin-1-yl)ethyl)-3-(thiophen-3-yl)-1,4-dihydroindeno[1,2-c]pyrazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL215901; BDBM50188276
Click to Show/Hide
|
||||
| Activity |
IC50 = 143000 nM
|
[9] | |||
| Compound Name |
7-((1H-Imidazol-1-yl)methyl)-3-(thiophen-3-yl)-1,4-dihydroindeno[1,2-c]pyrazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL212084; SCHEMBL4817151; BDBM50188272; 7-(imidazol-1-ylmethyl)-3-thiophen-3-yl-1,4-dihydroindeno[1,2-c]pyrazole
Click to Show/Hide
|
||||
| Activity |
IC50 = 147000 nM
|
[9] | |||
| Compound Name |
N-[4-[4-Fluoro-3-(trifluoromethyl)anilino]-6-(2-pyridin-2-ylethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-2,2-dimethylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2335019; BDBM50429668
Click to Show/Hide
|
||||
| Activity |
IC50 = 150900 nM
|
[58] | |||
| Compound Name |
5-Naphthalen-2-ylsulfanyl-9H-pyrimido[4,5-b]indole-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4060383; BDBM50235696
Click to Show/Hide
|
||||
| Activity |
IC50 = 160300 nM
|
[82] | |||
| Compound Name |
US9422297, Aag145-341
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3977751; BDBM242734
Click to Show/Hide
|
||||
| Activity |
IC50 = 163100 nM
|
[50] | |||
| Compound Name |
US9422297, Aag155-336
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3902576; BDBM242732
Click to Show/Hide
|
||||
| Activity |
IC50 = 167500 nM
|
[50] | |||
| Compound Name |
5-(4-Methoxyphenyl)sulfanyl-9H-pyrimido[4,5-b]indole-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4096329; BDBM50235700
Click to Show/Hide
|
||||
| Activity |
IC50 = 182200 nM
|
[82] | |||
| Compound Name |
7-((1H-1,2,3-Triazol-1-yl)methyl)-3-(thiophen-3-yl)-1,4-dihydroindeno[1,2-c]pyrazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL377327; SCHEMBL4808113; BDBM50188282; 3-thiophen-3-yl-7-(triazol-1-ylmethyl)-1,4-dihydroindeno[1,2-c]pyrazole
Click to Show/Hide
|
||||
| Activity |
IC50 = 190000 nM
|
[9] | |||
| Compound Name |
7-((4-Isopropylpiperazin-1-yl)methyl)-3-(thiophen-3-yl)-1,4-dihydroindeno[1,2-c]pyrazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL209912; SCHEMBL4814926; BDBM50188285; 7-[(4-propan-2-ylpiperazin-1-yl)methyl]-3-thiophen-3-yl-1,4-dihydroindeno[1,2-c]pyrazole
Click to Show/Hide
|
||||
| Activity |
IC50 = 190000 nM
|
[9] | |||
| Compound Name |
N-(4-Anilino-5-chloro-9H-pyrimido[4,5-b]indol-2-yl)-2,2-dimethylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2337367; BDBM50430566
Click to Show/Hide
|
||||
| Activity |
IC50 = 192000 nM
|
[2] | |||
| Compound Name |
5-Naphthalen-1-ylsulfanyl-9H-pyrimido[4,5-b]indole-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4088617; BDBM50235697
Click to Show/Hide
|
||||
| Activity |
IC50 = 193100 nM
|
[82] | |||
| Compound Name |
US9422297, Aag145-342
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3948546; BDBM242735
Click to Show/Hide
|
||||
| Activity |
IC50 = 198500 nM
|
[50] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 71 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Lapatinib
Click to Show/Hide
|
Approved | Compound Info | ||
| Synonyms |
FMM; Tycerb; Lapatinib Ditosylate; Lapatinib [INN]; Lapatinib tosilate hydrate; GSK 572016; GSK572016; GW 572016; GW 572016X; GW572016; Lapatinib (INN); Tykerb (TN); Lapatinib, Tykerb, GW572016; N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine; N-{3-CHLORO-4-[(3-FLUOROBENZYL)OXY]PHENYL}-6-[5-({[2-(METHYLSULFONYL)ETHYL]AMINO}METHYL)-2-FURYL]-4-QUINAZOLINAMINE; N-(3-Chloro-4-((3-fluorophenyl)methoxy)phenyl)-6-(5-((2-methylsulfonylethylamino)methyl)-2-furyl)quinazolin-4-amine; N-(3-Chloro-4-{[(3-fluorophenyl)methyl]oxy}phenyl)-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furanyl]-4-quinazolinamine; 4-[[3-Chloro-4-(3-fluorobenzyloxy)phenyl]amino]-6-[5-[[(2-methanesulfonylethyl)amino]methyl]furan-2-yl]quinazoline; Lapatinib (ERBB2 inhibitor)
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[83] | |||
| Compound Name |
N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[2-methylsulfonyl-1-(propan-2-ylamino)ethyl]furan-2-yl]quinazolin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3344213; BDBM50030384
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[83] | |||
| Compound Name |
2-Amino-4-(N-methyl-m-bromoanilino)-6-(2,5-dimethoxybenzyl)-7-methyl-pyrrolo[2,3-d]pyrimidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1254523; BDBM50326617
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[57] | |||
| Compound Name |
[[(1S)-1-[5-[4-[3-Chloro-4-[(3-fluorophenyl)methoxy]anilino]quinazolin-6-yl]furan-2-yl]-2-methylsulfonylethyl]amino] propanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3344217; BDBM50030378
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[83] | |||
| Compound Name |
N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[1-(ethylamino)-2-methylsulfonylethyl]furan-2-yl]quinazolin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3344211; SCHEMBL1352826; BDBM50030382
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[83] | |||
| Compound Name |
[[(1S)-1-[5-[4-[3-Chloro-4-[(3-fluorophenyl)methoxy]anilino]quinazolin-6-yl]furan-2-yl]-2-methylsulfonylethyl]amino] pentanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3344218; BDBM50030377
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[83] | |||
| Compound Name |
N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[2-methylsulfonyl-1-(2-methylsulfonylethylamino)ethyl]furan-2-yl]quinazolin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3344214; BDBM50030375
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[83] | |||
| Compound Name |
6-[5-(1-Amino-2-methylsulfonylethyl)furan-2-yl]-N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]quinazolin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3344209; SCHEMBL1351084; BDBM50030387
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[83] | |||
| Compound Name |
2-Amino-4-(N-methyl-m-bromoanilino)-6-(2-methylbenzyl)-7-methyl-pyrrolo[2,3-d]pyrimidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1254443; BDBM50326614
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[57] | |||
| Compound Name |
N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[1-(cyclohexylamino)-2-methylsulfonylethyl]furan-2-yl]quinazolin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3344212; BDBM50030388
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[83] | |||
| Compound Name |
CID 46866615
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3344220; SCHEMBL1352619; BDBM50030389
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[83] | |||
| Compound Name |
4-N-(3-Bromophenyl)-7-[(2,4-dichlorophenyl)methyl]pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956893; BDBM50366086
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[24] | |||
| Compound Name |
2-Amino-4-(N-methyl-m-bromoanilino)-6-benzyl-7-methyl-pyrrolo[2,3-d]pyrimidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1254286; BDBM50326611
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[57] | |||
| Compound Name |
N4-(3-Ethynylphenyl)-6-phenethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL520803; BDBM50271849; N4-(3-Ethynylphenyl)-6-(2-phenylethyl)-7H-pyrrolo[2,3-d ]pyrimidine-2,4-diamine
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[31] | |||
| Compound Name |
[[(1S)-1-[5-[4-[3-Chloro-4-[(3-fluorophenyl)methoxy]anilino]quinazolin-6-yl]furan-2-yl]-2-methylsulfonylethyl]amino] heptanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3344219; BDBM50030381
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[83] | |||
| Compound Name |
4-N-(3-Bromophenyl)-7-[(2,5-dimethoxyphenyl)methyl]pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956892; BDBM50366091
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[24] | |||
| Compound Name |
N-[4-(3-Bromo-4-fluoroanilino)-6-(2-pyridin-2-ylethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-2,2-dimethylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2335015; BDBM50429676
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[58] | |||
| Compound Name |
N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(1R)-1-(dimethylamino)-2-methylsulfonylethyl]furan-2-yl]quinazolin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3344221; SCHEMBL1353012; BDBM50030380
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[83] | |||
| Compound Name |
N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(1S)-1-(dimethylamino)-2-methylsulfonylethyl]furan-2-yl]quinazolin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3344216; SCHEMBL1351262; BDBM50030383
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[83] | |||
| Compound Name |
4-N-(3-Bromophenyl)-6-[(2,5-dimethoxyphenyl)methyl]-4-N-methyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1254444; BDBM50326615; 2-Amino-4-(N-methyl-m-bromoanilino)-6-(2,5-dimethoxybenzyl)-pyrrolo[2,3-d]pyrimidine
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[57] | |||
| Compound Name |
6-Phenethyl-N4-(3-(trifluoromethyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL483312; BDBM50271848; N4-(3-Trifluromethylphenyl)-6-(2-phenylethyl)-7Hpyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[31] | |||
| Compound Name |
CID 46866616
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3344215; SCHEMBL1351081; BDBM50030385
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[83] | |||
| Compound Name |
N4-(4-Fluoro-3-(trifluoromethyl)phenyl)-6-phenethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL482715; BDBM50271852; N4-[4-Fluoro-3-(trifluoromethyl)phenyl]-6-(2-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[31] | |||
| Compound Name |
2-Amino-4-(m-bromoanilino)-6-(2,5-dimethoxybenzyl)-7-methyl-pyrrolo[2,3-d]pyrimidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1254522; BDBM50326616
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[57] | |||
| Compound Name |
N4-(4-Chloro-2-fluorophenyl)-6-(2-phenylethyl)-7Hpyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL483313; BDBM50271850; N4-(4-chloro-2-fluorophenyl)-6-phenethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[31] | |||
| Compound Name |
N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[1-(methylamino)-2-methylsulfonylethyl]furan-2-yl]quinazolin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3344210; SCHEMBL1353264; BDBM50030379
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[83] | |||
| Compound Name |
4-N-(3-Chloro-4-fluorophenyl)-6-(2-pyridin-2-ylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2335378; BDBM50429673
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[58] | |||
| Compound Name |
2-Amino-4-(m-bromoanilino)-6-benzyl-7-methyl-pyrrolo-[2,3-d]pyrimidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1254285; BDBM50326610
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[57] | |||
| Compound Name |
N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[1-(dimethylamino)-2-methylsulfonylethyl]furan-2-yl]quinazolin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3344208; SCHEMBL1351264; BDBM50030376
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[83] | |||
| Compound Name |
4-N-(3-Bromophenyl)-4-N-methyl-6-[(2-methylphenyl)methyl]-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1254363; BDBM50326612; 2-Amino-4-(N-methyl-m-bromoanilino)-6-(2-methylbenzyl)-pyrrolo[2,3-d]pyrimidine
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[57] | |||
| Compound Name |
4-N-(4-Chlorophenyl)-6-(2-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL519147; BDBM50271851; N4-(4-Chlorophenyl)-6-(2-phenylethyl)-7H-pyrrolo[2,3-d ]pyrimidine-2,4-diamine
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[14] | |||
| Compound Name |
N-(3-Bromophenyl)-6-(2,4-dichlorobenzyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1094783; BDBM50318186
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[55] | |||
| Compound Name |
N4-(2-Isopropylphenyl)-6-(2,4-dichlorobenzyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1095776; BDBM50318181
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[55] | |||
| Compound Name |
6-(2,4-Dichlorobenzyl)-N-(3-(trifluoromethyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1094784; BDBM50318187
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[55] | |||
| Compound Name |
6-(2,4-Dichlorobenzyl)-N-(3-ethynylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1098440; BDBM50318188
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[55] | |||
| Compound Name |
6-[(2,4-Dichlorophenyl)methyl]-4-N-[3-(trifluoromethyl)phenyl]-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1095445; BDBM50318177; N4-(3-Trifluoromethylphenyl)-6-(2,4-dichlorobenzyl)-7Hpyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[55] | |||
| Compound Name |
N-(3-Bromophenyl)-6-(2,5-dimethoxybenzyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1094782; BDBM50318185
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[55] | |||
| Compound Name |
2-(Diethylamino)ethyl 4-methoxy-3-[[5-pyrimidin-5-yl-2-(trifluoromethoxy)phenyl]carbamoylamino]benzoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3633279; BDBM50130394
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[39] | |||
| Compound Name |
2-(Dimethylamino)ethyl 4-methoxy-3-[[3-pyrimidin-5-yl-5-(trifluoromethyl)phenyl]carbamoylamino]benzoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3633272; BDBM50130397
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[39] | |||
| Compound Name |
2,4-Diaminofuro[2,3-d]pyrimidine, 8
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL605413; BDBM33402
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[84] | |||
| Compound Name |
2-[Di(propan-2-yl)amino]ethyl 4-methoxy-3-[[5-(1H-pyrazol-4-yl)-2-(trifluoromethoxy)phenyl]carbamoylamino]benzoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3633284; BDBM50130389
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[39] | |||
| Compound Name |
2-Morpholin-4-ylethyl 3-[[3-(1H-indol-5-yl)-5-(trifluoromethyl)phenyl]carbamoylamino]-4-methoxybenzoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3633287; BDBM50130386
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[39] | |||
| Compound Name |
2-Morpholin-4-ylethyl 4-methoxy-3-[[3-pyridin-3-yl-5-(trifluoromethyl)phenyl]carbamoylamino]benzoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3633286; BDBM50130387
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[39] | |||
| Compound Name |
5-[2-Cyclopropyl-2-(2-methoxyphenyl)ethenyl]furo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL594320
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[84] | |||
| Compound Name |
2-[Di(propan-2-yl)amino]ethyl 4-methoxy-3-[[5-pyrimidin-5-yl-2-(trifluoromethoxy)phenyl]carbamoylamino]benzoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3633283; BDBM50130390
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[39] | |||
| Compound Name |
5-[2-(2-Methoxyphenyl)-3-methylpent-1-enyl]furo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL603849
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[84] | |||
| Compound Name |
2-[Di(propan-2-yl)amino]ethyl 3-[[3-(1H-indol-5-yl)-5-(trifluoromethyl)phenyl]carbamoylamino]-4-methoxybenzoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3633281; BDBM50130392
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[39] | |||
| Compound Name |
2,4-Diaminofuro[2,3-d]pyrimidine, 13
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL594339; BDBM33407
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[84] | |||
| Compound Name |
2-[Di(propan-2-yl)amino]ethyl 4-methoxy-3-[[5-(1-methylpyrazol-4-yl)-2-(trifluoromethoxy)phenyl]carbamoylamino]benzoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3633285; BDBM50130388
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[39] | |||
| Compound Name |
2-[Di(propan-2-yl)amino]ethyl 3-[[5-(1H-indol-5-yl)-2-(trifluoromethoxy)phenyl]carbamoylamino]-4-methoxybenzoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3633282; BDBM50130391
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[39] | |||
| Compound Name |
2,4-Diaminofuro[2,3-d]pyrimidine, 12
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL606362; BDBM33406
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[84] | |||
| Compound Name |
2,4-Diaminofuro[2,3-d]pyrimidine, 11
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL594790; BDBM33405; D2F
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[84] | |||
| Compound Name |
5-[2-(2-Methoxyphenyl)-4-methylpent-1-enyl]furo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL593154
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[84] | |||
| Compound Name |
5-(4-Chlorophenyl)sulfanyl-9H-pyrimido[4,5-b]indole-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4079829; BDBM50235699
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[82] | |||
| Compound Name |
5-[2-(2-Methoxyphenyl)-3-methylbut-1-enyl]furo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL594810
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[84] | |||
| Compound Name |
5-[2-(2-Methoxyphenyl)hex-1-enyl]furo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL604879
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[84] | |||
| Compound Name |
Chembl4164979
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 = 564000 nM
|
[85] | |||
| Compound Name |
4-((3-(Thiophen-3-yl)-1,4-dihydroindeno[1,2-c]pyrazol-7-yl)methyl)piperazine-1-carbaldehyde
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL211089; SCHEMBL4811223; BDBM50188280; 4-[(3-thiophen-3-yl-1,4-dihydroindeno[1,2-c]pyrazol-7-yl)methyl]piperazine-1-carbaldehyde
Click to Show/Hide
|
||||
| Activity |
IC50 = 665000 nM
|
[9] | |||
| Compound Name |
N-Ethyl-N-((3-(thiophen-3-yl)-1,4-dihydroindeno[1,2-c]pyrazol-7-yl)methyl)ethanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL213531; SCHEMBL4818918; BDBM50188270; N-ethyl-N-[(3-thiophen-3-yl-1,4-dihydroindeno[1,2-c]pyrazol-7-yl)methyl]ethanamine
Click to Show/Hide
|
||||
| Activity |
IC50 = 824000 nM
|
[9] | |||
| Compound Name |
N-[3-[3-[[2-Methyl-6-(2-morpholin-4-ylethylamino)pyrimidin-4-yl]amino]-1H-pyrazol-5-yl]phenyl]benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1807788; SCHEMBL12077782; BDBM50349021
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[86] | |||
| Compound Name |
1-[4-(3-Amino-1H-indazol-7-yl)phenyl]-3-(3-methylphenyl)urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2046838; BDBM50387357
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[87] | |||
| Compound Name |
N-(Pyridin-3-ylmethyl)benzofuro[2,3-b]pyridin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1290178; BDBM50331614
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[88] | |||
| Compound Name |
N-[3-[3-[[6-(4-Hydroxypiperidin-1-yl)-2-methylpyrimidin-4-yl]amino]-1H-pyrazol-5-yl]phenyl]benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1807785; SCHEMBL12077625; BDBM50349018
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[86] | |||
| Compound Name |
4-Phenyl-[1]benzofuro[2,3-b]pyridine-3,6-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2163772; BDBM50395892
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[89] | |||
| Compound Name |
CID 56659825
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1807485; SCHEMBL12077735; BDBM50349017
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[86] | |||
| Compound Name |
N-(4-Methoxybenzyl)benzofuro[2,3-b]pyridin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1290072; BDBM50331612
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| Activity |
Ki > 1000000 nM
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[88] | |||
| Compound Name |
N-(3-Chlorobenzyl)benzofuro[2,3-b]pyridin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1290073; BDBM50331615
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| Activity |
Ki > 1000000 nM
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[88] | |||
| Compound Name |
1-(3-Methylphenyl)-3-[4-(3-oxo-1,2-dihydroisoindol-4-yl)phenyl]urea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2046837; BDBM50387356
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| Activity |
IC50 > 1000000 nM
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[87] | |||
| Compound Name |
CID 56676977
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1807484; SCHEMBL12077993; BDBM50349016
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| Activity |
IC50 > 1000000 nM
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[86] | |||
| Compound Name |
6-(4-Methylpiperazin-1-yl)-3-(thiophen-2-yl)-1,4-dihydroindeno[1,2-c]pyrazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL379103; BDBM50188288
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| Activity |
IC50 = 1005000 nM
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[9] | |||
| Compound Name |
(4-Methylpiperazin-1-yl)(3-(thiophen-3-yl)-1,4-dihydroindeno[1,2-c]pyrazol-7-yl)methanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL378007; BDBM50188267
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| Activity |
IC50 = 4081000 nM
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[9] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
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| REF 82 | Synthesis and evaluation of 5-(arylthio)-9H-pyrimido[4,5-b]indole-2,4-diamines as receptor tyrosine kinase and thymidylate synthase inhibitors and as antitumor agents. Bioorg Med Chem Lett. 2017 Apr 1;27(7):1602-1607. | ||||
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| REF 84 | Design, synthesis, and X-ray crystal structures of 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase i... Bioorg Med Chem. 2009 Oct 15;17(20):7324-36. | ||||
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| REF 88 | Discovery and selectivity-profiling of 4-benzylamino 1-aza-9-oxafluorene derivatives as lead structures for IGF-1R inhibitors. Bioorg Med Chem Lett. 2010 Dec 1;20(23):6915-9. | ||||
| REF 89 | Multitargeted drug development: Discovery and profiling of dihydroxy substituted 1-aza-9-oxafluorenes as lead compounds targeting Alzheimer disease relevant kinases. Bioorg Med Chem Lett. 2012 Nov 15;22(22):6914-8. | ||||
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