Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T83059 | Target Info | |||
| Target Name | Tankyrase (TNKS) | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | NO-GeName | ||||
| Biochemical Class | Glycosyltransferases | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 1 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
IWR-1-endo
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Investigative | Compound Info | ||
| Synonyms |
IWR-1; CHEMBL562310; C25H19N3O3; IWR1-endo; exo-IWR 1; IWR-1 endo; endo-IWR-1; cc-714; SCHEMBL15315470; EX-A642; BCP05700; ZINC2483738; 1806AH; 2489AH; BDBM50007583; MFCD18086875; CCG-208104; IWR-1, >=98% (HPLC); HY-12238; B2306; BRD-K61314889-001-01-0; Q27132252
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| Activity |
IC50 = 136000 nM
|
[1] | |||
| Non Binders of This Target (in total, 1 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one
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Investigative | Compound Info | ||
| Synonyms |
XAV-939; XAV939; XAV 939; C14H11F3N2OS; CHEMBL1086580; 2-(4-(trifluoromethyl)phenyl)-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-4-ol; MFCD16879017; 2-[4-(trifluoromethyl)phenyl]-7,8-dihydro-5H-thiino[4,3-d]pyrimidin-4-ol; 2-[4-(Trifluoromethyl)phenyl]-7,8-Dihydro-5h-Thiopyrano[4,3-D]pyrimidin-4-Ol; NVP-XAV-939; NVP-XAV 939; Maybridge3_005018; cc-343; MLS006012021; SCHEMBL7783488; TB3748-GMP; SCHEMBL15315468; AOB4150; DTXSID60369423; XAV939,XAV-939; BCPP000009; HMS1445E02; HMS3414D07; HMS3648B17; HMS3654O16; HMS3678D07; HMS3743E05; BCP02128; EX-A1760; ABP000288; BDBM50188594; BDBM50318567; s1180; ZINC13467799; AKOS015954858; AKOS024457786; AKOS026750243; CCG-208105; CS-0494; MCULE-6143908878; SB19432; IDI1_016405; KS-0000181U; NCGC00250397-01; NCGC00484998-01; AC-28393; AK198691; CS-10386; HY-15147; SC-95571; SMR003874205; XAV 939/XAV939,NVP-XAV939; XAV939, >=98% (HPLC); DB-067924; FT-0675873; SW218311-2; X7558; A25698; W-5666; SR-01000946403; J-511234; SR-01000946403-1; BRD-K12762134-001-01-3; BRD-K12762134-001-05-4; Q27132250; 6,8-Dihydro-2-[4-(trifluoromethyl)phenyl]-5H-thiopyrano[3,4-d]pyrimidine; 2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiopyrano-[4,3-d]pyrimidin-4-ol; 2-[4-(trifluoromethyl)phenyl]-1H,4H,5H,7H,8H-thiopyrano[4,3-d]pyrimidin-4-one
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| Activity |
IC50 = 272000 nM
|
[1] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Discovery of a class of novel tankyrase inhibitors that bind to both the nicotinamide pocket and the induced pocket. J Med Chem. 2013 Feb 14;56(3):1341-5. | ||||
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