Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T85223 | Target Info | |||
| Target Name | Deoxyribonuclease I (DNASE1) | ||||
| Synonyms |
Herpesvirus alkaline deoxyribonuclease; Herpesvirus alkaline DNase; Dornase alfa; DNase I; DNASE1; Alkaline deoxyribonuclease
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|
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| Target Type | Literature-reported Target | ||||
| Gene Name | DNASE1 | ||||
| Biochemical Class | Endodeoxyribonucleases | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 56 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
3-hydroxyquinazoline-2,4(1H,3H)-dione
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|
Investigative | Compound Info | ||
| Synonyms |
3-hydroxyquinazoline-2,4(1H,3H)-dione; 3-hydroxy-quinazoline-2,4-dione; CHEMBL183852; 5329-43-1; NSC2552; AC1Q6JF3; AC1L58DP; N-hydroxy quinazolinedione, 4; SCHEMBL1520708; 3-hydroxyquinazoline-2,4-dione; CTK4J7468; BDBM33412; DTXSID00277492; ZINC1640999; NSC-2552; 3-hydroxy-1H-quinazoline-2,4-dione; 3-HYDROXY-2,3H)-QUINAZOLINEDIONE
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
5-Hydroxy-N-(2-morpholin-4-ylethyl)-6-oxo-2-thiophen-2-yl-1H-pyrimidine-4-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3617285; BDBM50121882
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|
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| Activity |
IC50 = 58900 nM
|
[1] | |||
| Compound Name |
N-(2-Acetamidoethyl)-5-hydroxy-6-oxo-2-thiophen-2-yl-1H-pyrimidine-4-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3617282; BDBM50121878
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| Activity |
IC50 = 62600 nM
|
[1] | |||
| Compound Name |
5-Hydroxy-N-methyl-6-oxo-2-thiophen-2-yl-1H-pyrimidine-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3617205; BDBM50121872
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|
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| Activity |
IC50 = 67600 nM
|
[1] | |||
| Compound Name |
N-(3-Hydroxy-2,4-dioxo-1H-quinazolin-6-yl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3617201; BDBM50121863
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|
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| Activity |
IC50 = 87000 nM
|
[1] | |||
| Compound Name |
1-[(4-Chlorophenyl)methyl]-3-[(3,4-dihydroxyphenyl)methyl]imidazolidin-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3617020; BDBM50121723
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|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
5-(3-Chloro-4-fluorophenyl)-3-hydroxy-1H-pyridin-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3617024; BDBM50121747
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N-[(2,4-Dichlorophenyl)methyl]-2-(3,4-dihydroxyphenyl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3617018; BDBM50121721
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N-[4-(5-Hydroxy-6-oxo-1H-pyridin-3-yl)phenyl]acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3617025; BDBM50121750
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
2-Anilino-N-[2-(3,4-dihydroxyphenyl)ethyl]acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616992; BDBM50121705
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N'-[(E)-(3,4-Dihydroxyphenyl)methylidene]-2-(phenylamino)acetohydrazide (non-preferred name)
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616991; BDBM50121706; STK699580; ZINC32923227; AKOS000960964
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
1-(2,4-Dichlorophenyl)-N-[(3,4-dihydroxyphenyl)methyl]methanesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3617017; BDBM50121719
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|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
2-(4-Acetylpiperazin-1-yl)-N-[(3,4-dihydroxyphenyl)methyl]acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3617011; BDBM50121830
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|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N-Butan-2-yl-5-hydroxy-6-oxo-2-thiophen-2-yl-1H-pyrimidine-4-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3617209; BDBM50121876
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
3-Hydroxy-5-(1-methylindazol-6-yl)-1H-pyridin-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3617026; BDBM50121751
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|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N-(3-Hydroxy-2,4-dioxo-1H-quinazolin-8-yl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3617199; BDBM50121865
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
5,6-Dihydroxy-2-thiophen-2-yl-pyrimidine-4-carboxylic acid methyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL187010; Methyl 5,6-dihydroxy-2-thien-2-ylpyrimidine-4-carboxylate; SCHEMBL3833902; DTXSID80388439; 3046AJ; BDBM50121868; ZINC28390014; SB36992; DB-069771; FT-0713724; methyl 5,6-dihydroxy-2-(2-thienyl)pyrimidine-4-carboxylate; methyl 5,6-dihydroxy-2-(thien-2-yl)pyrimidine-4-carboxylate; methyl 5-hydroxy-4-oxo-2-thiophen-2-yl-1H-pyrimidine-6-carboxylate; 4-Pyrimidinecarboxylic acid, 5,6-dihydroxy-2-(2-thienyl)-, methyl ester; 5,6-dihydroxy-2-thiophen-2-ylpyrimidine-4-carboxylic acid methyl ester; METHYL 5,6-DIHYDROXY-2-(THIOPHEN-2-YL)PYRIMIDINE-4-CARBOXYLATE
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
3-Hydroxy-6-phenyl-1H-pyrimidine-2,4-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3617203; BDBM50121861
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
N-[(3,4-Dihydroxyphenyl)methyl]-1-[(4-fluorophenyl)methyl]piperidine-4-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3617012; BDBM50121713
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N-[(2-Chloro-3,4-dihydroxyphenyl)methyl]-2-(2,4-dichlorophenyl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3617015; BDBM50121717
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
3-Hydroxy-1H-thieno[2,3-d]pyrimidine-2,4-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL361350; NSC237046; SCHEMBL1894456; DTXSID50311072; BDBM50157832; NSC-237046; 3-Hydroxy-4a,7a-dihydro-1H-thieno[2,3-d]pyrimidine-2,4-dione
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
1-(4-Chlorophenyl)-3-[(3,4-dihydroxyphenyl)methyl]urea
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3617019; BDBM50121722
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|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
2-(2,4-Dichlorophenyl)-N-[(2-fluoro-4,5-dihydroxyphenyl)methyl]acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3617016; BDBM50121718
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|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
5,6-Dihydroxy-2-thiophen-2-yl-pyrimidine-4-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL181653; 5,6-dihydroxy-2-(2-thienyl)pyrimidine-4-carboxylic Acid; 5,6-dihydroxy-2-(thiophen-2-yl)pyrimidine-4-carboxylic acid; C9H6N2O4S; SCHEMBL3838465; CTK1B4225; CTK8I5592; DTXSID20388438; ZINC6142725; 3045AJ; BDBM50153250; MFCD09701385; SB36991; DB-069770; FT-0730764; Z-7590; 2-(2-thienyl)-5,6-dihydroxy-4-carboxypyrimidine; 4-Pyrimidinecarboxylic acid, 5,6-dihydroxy-2-(2-thienyl)-; 5,6-dihydroxy-2-thiophen-2-ylpyrimidine-4-carboxylic acid; 5-hydroxy-4-oxo-2-thiophen-2-yl-1H-pyrimidine-6-carboxylic acid; 5-hydroxy-6-oxo-2-(2-thienyl)-1H-pyrimidine-4-carboxylic acid; 4-Pyrimidinecarboxylic acid, 1,6-dihydro-5-hydroxy-6-oxo-2-(2-thienyl)-; 5-Hydroxy-6-oxo-2-(thiophen-2-yl)-1,6-dihydropyrimidine-4-carboxylic acid; 5-Hydroxy-6-oxo-2-(thiophen-2-yl)-3,6-dihydropyrimidine-4-carboxylic acid
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-[3-[(4-Chlorophenyl)methyl]-1,2,4-oxadiazol-5-yl]benzene-1,2-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3617022; BDBM50121725
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N-[(3,4-Dihydroxyphenyl)methyl]benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616998; BDBM50121699
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|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
5,6-Dihydroxy-2-phenylpyrimidine-4-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
5,6-Dihydroxy-2-phenyl-pyrimidine-4-carboxylic acid; CHEMBL440562; MFCD09701383; 5-hydroxy-4-oxo-2-phenyl-1H-pyrimidine-6-carboxylic acid; pyrimidinol carboxylic acid, 6; SCHEMBL3835083; BDBM33414; CTK2C4689; DTXSID50333411; KS-00000D0S; ZINC3583890; 3040AJ; BDBM50121869; NE64315; SB37969; AK156529; CS-12213; SY040243; DB-073071; FT-0757834; 5,6-Dihydroxy-2-phenylpyrimidine-4-carboxylicAcid; 2-Phenyl-5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxylic acid; 4-Pyrimidinecarboxylic acid, 1,6-dihydro-5-hydroxy-6-oxo-2-phenyl-; 5-Hydroxy-6-oxo-2-phenyl-3,6-dihydropyrimidine-4-carboxylic acid
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
5-Hydroxy-N-(2-hydroxyethyl)-6-oxo-2-thiophen-2-yl-1H-pyrimidine-4-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3617207; BDBM50121874
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-(2,4-Dichlorophenyl)-1-(6,7-dihydroxy-3,4-dihydro-1H-isoquinolin-2-yl)ethanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3617013; BDBM50121714
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N-[(3,4-Dihydroxyphenyl)methyl]-3-phenylpropanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616995; BDBM50121702
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N-[(3,4-Dihydroxyphenyl)methyl]-2-phenylacetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616997; BDBM50121700
Click to Show/Hide
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
2-(4-Chlorophenyl)-N-[(3,4-dihydroxyphenyl)methyl]acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3617000; BDBM50121697
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N-(4-Fluorobenzyl)-5,6-dihydroxy-2-thien-2-ylpyrimidine-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL216874; Dihydroxypyrimidine, 5; SCHEMBL5117933; BDBM22714; BDBM50121880; 4-Pyrimidinecarboxamide, 5,6-dihydroxy-N-[(4-fluorophenyl)methyl]-2-(2-thienyl)-; N-[(4-fluorophenyl)methyl]-5,6-dihydroxy-2-(2-thienyl)pyrimidine-4-carboxamide; N-[(4-fluorophenyl)methyl]-5,6-dihydroxy-2-(thiophen-2-yl)pyrimidine-4-carboxamide; N-[(4-fluorophenyl)methyl]-5-hydroxy-4-oxo-2-thiophen-2-yl-1H-pyrimidine-6-carboxamide
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Methyl 5,6-dihydroxy-2-phenylpyrimidine-4-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
5,6-DIHYDROXY-2-PHENYL-PYRIMIDINE-4-CARBOXYLIC ACID METHYL ESTER; CHEMBL3617204; DTXSID00715687; BDBM50121870; MFCD09701382; ZINC33268084; MCULE-8828266483; NE64262; SB37968; SY045090; DB-073070; FT-0769675; 5,6-Dihydroxy-2-phenylpyrimidine-4-carboxylic acid methyl ester; Methyl 5-hydroxy-6-oxo-2-phenyl-3,6-dihydropyrimidine-4-carboxylate
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-Anilino-N-[(3,4-dihydroxyphenyl)methyl]acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616993; BDBM50121704
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
5-(4-Fluorophenyl)-3-hydroxy-1H-pyridin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2443225; 2(1H)-Pyridinone, 5-(4-fluorophenyl)-3-hydroxy-; SCHEMBL15614331; BDBM50121726
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
1-Benzyl-3-hydroxythieno[2,3-d]pyrimidine-2,4(1H,3H)-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL182974; CTK3D8838; DTXSID90658695; BDBM50157850; 3-Hydroxy-1-phenyl-1H-thieno[2,3-d]pyrimidine-2,4-dione; Thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione, 3-hydroxy-1-(phenylmethyl)-
Click to Show/Hide
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-Anilino-N-(3,4-dihydroxyphenyl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616994; BDBM50121703
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N-(3-Hydroxy-2,4-dioxo-1H-quinazolin-7-yl)acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3617200; NSC332063; BDBM50121864; NSC-332063
Click to Show/Hide
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
5-Hydroxy-1-methyl-6-oxo-2-(2-thienyl)pyrimidine-4-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL366051; SCHEMBL4032042; BDBM50153254; 5,6-dihydroxy-1-methyl-2-thiophen-2-yl-pyrimidine-4-carboxylic acid; 5-hydroxy-1-methyl-6-oxo-2-thiophen-2-ylpyrimidine-4-carboxylic acid; 5-Hydroxy-1-methyl-6-oxo-2-(thien-2-yl)-1,6-dihydropyrimidine-4-carboxylic acid; 5-hydroxy-1-methyl-6-oxo-2-(thiophen-2-yl)-1,6-dihydropyrimidine-4-carboxylic acid; 5-Hydroxy-1-methyl-6-oxo-2-thiophen-2-yl-1,6-dihydro-pyrimidine-4-carboxylic acid
Click to Show/Hide
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
3-Hydroxy-1-methylquinazoline-2,4(1H,3H)-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3617202; NSC193561; 2,4(1H,3H)-Quinazolinedione, 3-hydroxy-1-methyl-; CTK8I4892; DTXSID60307648; BDBM50121862; NSC-193561; 2,3H)-Quinazolinedione, 3-hydroxy-1-methyl-; 3-Hydroxy-1-methyl-2,4(1H,3H)-quinazolinedione #
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
3-Hydroxy-7-(4-methylphenyl)furo[3,2-d]pyrimidine-2,4(1H,3H)-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL182381; CTK3D8835; DTXSID50658691; 3-hydroxy-7-(p-tolyl)furo[3,2-d]pyrimidine-2,4(1H,3H)-dione; BDBM50157846; 3-Hydroxy-7-p-tolyl-1H-furo[3,2-d]pyrimidine-2,4-dione; Furo[3,2-d]pyrimidine-2,4(1H,3H)-dione, 3-hydroxy-7-(4-methylphenyl)-
Click to Show/Hide
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
3-Hydroxy-5-(3-pyrazol-1-ylphenyl)-1H-pyridin-2-one
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3617023; BDBM50121727
Click to Show/Hide
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
5-Hydroxy-6-oxo-N-pyridin-3-yl-2-thiophen-2-yl-1H-pyrimidine-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3617284; BDBM50121881
Click to Show/Hide
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
3-Hydroxy-7-phenyl-1H-thieno[3,2-d]pyrimidine-2,4-dione
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL361011; SCHEMBL1886589; CTK3D8840; DTXSID80467753; BDBM50157830; Thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione, 3-hydroxy-7-phenyl-
Click to Show/Hide
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
N-[(3,4-Dihydroxyphenyl)methyl]-2-phenoxyacetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616996; BDBM50121701
Click to Show/Hide
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
2-(2,4-Dichlorophenyl)-N-[(3,4-dihydroxyphenyl)methyl]-N-methylacetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3617014; BDBM50121715
Click to Show/Hide
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
2-(2-Chlorophenyl)-N-[(3,4-dihydroxyphenyl)methyl]acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3617001; BDBM50121696
Click to Show/Hide
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
5-Hydroxy-6-oxo-N-propyl-2-thiophen-2-yl-1H-pyrimidine-4-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3617206; BDBM50121873
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-(2,4-Dichlorophenyl)-N-[(3,4-dihydroxyphenyl)methyl]acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3617002; BDBM50121695
Click to Show/Hide
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N-[(3,4-Dihydroxyphenyl)methyl]cyclopentanecarboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3617006; BDBM50121693
Click to Show/Hide
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N'-[(E)-(2,5-Dibromo-3,4-dihydroxyphenyl)methylidene]-2-[(3-methylphenyl)amino]acetohydrazide (non-preferred name)
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3617028; SCHEMBL8289491; BDBM50121752; STK750209; AKOS001705977; MCULE-9848286753; N'~1~-[(E)-1-(2,5-dibromo-3,4-dihydroxyphenyl)methylidene]-2-(3-toluidino)acetohydrazide
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
N-[(3,4-Dihydroxyphenyl)methyl]-2-(4-morpholin-4-ylphenyl)acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3617010; BDBM50121707
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
4-[[3-(4-Chlorophenyl)-1,2,4-oxadiazol-5-yl]methyl]benzene-1,2-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3617021; BDBM50121724
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
5,6-Dihydroxy-2-(2-thienyl)pyrimidine-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL223338; SCHEMBL6644722; CTK2I4797; DTXSID80715721; 5-hydroxy-4-oxo-2-thiophen-2-yl-1H-pyrimidine-6-carboxamide; BDBM50121871; 4-Pyrimidinecarboxamide, 5,6-dihydroxy-2-(2-thienyl)-; 4-Pyrimidinecarboxamide, 1,6-dihydro-5-hydroxy-6-oxo-2-(2-thienyl)-; 5-Hydroxy-6-oxo-2-(thiophen-2-yl)-1,6-dihydropyrimidine-4-carboxamide; 5-Hydroxy-6-oxo-2-(thiophen-2-yl)-3,6-dihydropyrimidine-4-carboxamide
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| Activity |
IC50 ~ 100000 nM
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[1] | |||
| Compound Name |
2-Cyclohexyl-N-[(3,4-dihydroxyphenyl)methyl]acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3617007; BDBM50121692
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 1 non binders) | Download | Top | |||
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| Compound Name |
4-[(4,6-Dichloro-1,3,5-triazin-2-yl)amino]-2-(3-hydroxy-6-oxoxanthen-9-yl)benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL222509; CBChromo1_000291; Probes1_000495; Probes2_000050; CBDivE_003184; SCHEMBL6037129; ZINC3877744; BDBM50206432; DR-396
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| Activity |
IC50 > 300000 nM
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[3] | |||
| References | Top | ||||
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| REF 1 | N-Hydroxyimides and hydroxypyrimidinones as inhibitors of the DNA repair complex ERCC1-XPF. Bioorg Med Chem Lett. 2015 Oct 1;25(19):4104-8. | ||||
| REF 2 | Catechols and 3-hydroxypyridones as inhibitors of the DNA repair complex ERCC1-XPF. Bioorg Med Chem Lett. 2015 Oct 1;25(19):4097-103. | ||||
| REF 3 | Deoxyribonuclease inhibitors. Eur J Med Chem. 2014 Dec 17;88:101-11. | ||||
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