Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T86052 | Target Info | |||
| Target Name | Telomerase reverse transcriptase (TERT) | ||||
| Synonyms |
Telomerase-associated protein 2; Telomerase catalytic subunit; TRT; TP2; TCS1; HEST2; EST2
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| Target Type | Clinical trial Target | ||||
| Gene Name | TERT | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 95 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Doxorubicin
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|
Approved | Compound Info | ||
| Synonyms |
doxorubicin; 23214-92-8; Doxil; Doxorubicine; Adriablastin; Doxorubicinum; 14-Hydroxydaunomycin; 14-Hydroxydaunorubicine; Doxorubicina; Adriamycin semiquinone; Doxorubicinum [INN-Latin]; Doxorubicine [INN-French]; Doxorubicina [INN-Spanish]; Myocet; FI 106; Doxorubicin [USAN:INN:BAN]; CCRIS 739; NDC 38242-874; HSDB 3070; UNII-80168379AG; NCI-C01514; EINECS 245-495-6; CHEMBL53463; CHEBI:28748; 5,12-Naphthacenedione,; ADM; ADR; ThermoDox; Aerosolized Doxorubicin; Doxorubicin citrate; RDF Rubex; Conjugate of doxorubicin with humanized monoclonal antibody LL1 against CD74; DM2; JT9100000; Adiblastine (hydrochloride salt); Adr iablatina (hydrochloride salt); Adriablastine (hydrochloride salt); Adriablatina (hydrochloride salt); Adriacin (hydrochloride salt); Adriamycin PFS (TN); Adriamycin PFS (hydrochloride salt); Adriamycin RDF (TN); Adriamycin RDF (hydrochloride salt); Adriblastina (TN); Adriblastina (hydrochloride salt); Adriblatina (hydrochloride salt); Caelyx (TN); Conjugate of doxorubicin with monoclonal antibody P4/D10 against GP120; DOX-SL; Doxorubicin hydrochloride (hydrochloride salt); Doxorubicin-hLL1; Doxorubicin-hLL1 conjugate; Farmablastina (hydrochloride salt); Hydroxydaunomycin hydrochlor ide (hydrochloride salt); Hydroxydaunomycin hydrochloride (hydrochloride salt); Hydroxydaunorubicin hydrochloride (hydrochloride salt); Myocet (TN); Rubex (TN); Rubex (hydrochloride salt); TLC D-99; Doxorubicin (USAN/INN); Doxorubicin-P4/D10; Doxorubicin-P4/D10 conjugate; Cantide + adriamycin
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| Activity |
IC50 = 73000 nM
|
[1] | |||
| Compound Name |
Resveratrol
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Phase 3 | Compound Info | ||
| Synonyms |
Resveratrol; Resvida; KUC104385N; R 5010; SRT 501; Cis-resveratrol; PREVENTION 8 (RESVERATROL); RM-1812; SRT-501; Trans-resveratrol; CU-01000001503-3; KSC-10-164; Resveratrol-3-sulfate; Trans-3,4',5-trihydroxystilbene; Trans-3,4′,5-Trihydroxystilbene; Trans-1,2-(3,4',5-Trihydroxydiphenyl)ethylene; (E)-5-(2-(4-hydroxyphenyl)ethenyl)-1,3-benzenediol
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| Activity |
IC50 = 85000 nM
|
[2] | |||
| Compound Name |
1,3-Bis(3-(4-(4-(pyrrolidin-1-yl)butanamido)phenylcarbamoyl)phenyl)urea
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL453250; SCHEMBL14041773; BDBM50246818
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| Activity |
EC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
3-Morpholin-4-yl-N-[7-(3-morpholin-4-yl-propionylamino)-9-oxo-9H-fluoren-2-yl]-propionamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL310651; BDBM50079126; N,N'-(9-Oxo-9H-fluorene-2,7-diyl)bis(3-morpholinopropionamide)
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
3,6-Bis[3-(heptamethyleneimino)piperizinopropionamido)acridine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL310838; BDBM50080852; N,N''-(acridine-3,6-diyl)bis(3-(azocan-1-yl)propanamide); N,N'-(Acridine-3,6-diyl)bis[3-(octahydroazocine-1-yl)propanamide]; 3-Azocan-1-yl-N-[6-(3-azocan-1-yl-propionylamino)-acridin-3-yl]-propionamide
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
3-[3-(Dimethylamino)propylamino]-N-[2-[4-[3-(dimethylamino)propylamino]quinazolin-2-yl]phenyl]propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2376061; BDBM50432804
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
N-{9-Oxo-7-[3-(4-pyridin-2-yl-piperazin-1-yl)-propionylamino]-9H-fluoren-2-yl}-3-(4-pyridin-2-yl-piperazin-1-yl)-propionamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL315704; BDBM50079128; N,N'-(9-Oxo-9H-fluorene-2,7-diyl)bis[3-[4-(2-pyridyl)piperazino]propionamide]
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
3-Morpholin-4-yl-N-[8-(3-morpholin-4-yl-propionylamino)-9,10-dioxo-9,10-dihydro-anthracen-1-yl]-propionamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL144208; BDBM50068317
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| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
3-(Dipropylamino)-N-[4-[3-(dipropylamino)propanoylamino]-9,10-dioxoanthracen-1-yl]propanamide;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL544572
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| Activity |
IC50 = 50000 nM
|
[8] | |||
| Compound Name |
2,6-Bis[3-morpholinopropanoylamino]anthraquinone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL33505; SCHEMBL9630665; BDBM50005756
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| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
12-(1,1'-Trimethylene-3'-methyl-2,2'-bi[1H-indole]-3-ylacetylamino)dodecanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL156771; BDBM50097321
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| Activity |
IC50 = 50000 nM
|
[9] | |||
| Compound Name |
7,8,3'-Trihydroxyflavone
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Investigative | Compound Info | ||
| Synonyms |
7,8-dihydroxy-2-(3-hydroxyphenyl)chromen-4-one; 7,8-dihydroxy-2-(3-hydroxyphenyl)-4H-chromen-4-one; CHEMBL225513; 4H-1-Benzopyran-4-one, 7,8-dihydroxy-2-(3-hydroxyphenyl)-; TNP00054; 3',7,8-Trihydroxyflavone; 7,8,3''-Trihydroxyflavone; 7,8,3'-Trihydroxy Flavone; SCHEMBL4649946; CTK4C0843; ZINC39320; DTXSID00350274; BDBM50157558; MFCD00143512; AKOS024282399; MCULE-1925242226; NCGC00017190-01; NCGC00017190-02; NCGC00142444-01; ST056013; FT-0707045; J-007031; 7,8-dihydroxy-2-(3-hydroxyphenyl)-4H-benzopyran-4-one
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| Activity |
IC50 = 50000 nM
|
[10] | |||
| Compound Name |
1,3-Bis(3-(4-(3-(pyrrolidin-1-yl)propanamido)phenylcarbamoyl)phenyl)urea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL446231; BDBM50246817
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|
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| Activity |
EC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
N-{9-Oxo-7-[3-(4-pyrimidin-2-yl-piperazin-1-yl)-propionylamino]-9H-fluoren-2-yl}-3-(4-pyrimidin-2-yl-piperazin-1-yl)-propionamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL329427; BDBM50079134; N,N'-(9-Oxo-9H-fluorene-2,7-diyl)bis[3-[4-(2-pyrimidinyl)piperazino]propionamide]
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
3-(4-Benzyl-piperazin-1-yl)-N-{7-[3-(4-benzyl-piperazin-1-yl)-propionylamino]-9-oxo-9H-fluoren-2-yl}-propionamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL314100; BDBM50079145; N,N'-(9-Oxo-9H-fluorene-2,7-diyl)bis[3-(4-benzylpiperazino)propionamide]
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
3,6-Bis[(3-morpholinopropionamido)] acridine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL421143; BDBM50080843; Q27463741; N,N''-(acridine-3,6-diyl)bis(3-morpholinopropanamide); N,N'-(Acridine-3,6-diyl)bis(3-morpholinopropanamide); N,N'-acridine-3,6-diylbis(3-morpholin-4-ylpropanamide); 3-Morpholin-4-yl-N-[6-(3-morpholin-4-yl-propionylamino)-acridin-3-yl]-propionamide
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
N-{9-Oxo-7-[3-(4-phenyl-piperazin-1-yl)-propionylamino]-9H-fluoren-2-yl}-3-(4-phenyl-piperazin-1-yl)-propionamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL91106; BDBM50079151; N,N'-(9-Oxo-9H-fluorene-2,7-diyl)bis[3-(4-phenylpiperazino)propionamide]
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
3-(4-Benzyl-piperidin-1-yl)-N-{6-[3-(4-benzyl-piperidin-1-yl)-propionylamino]-acridin-3-yl}-propionamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL310569; BDBM50080838; N,N'-(Acridine-3,6-diyl)bis[3-(4-benzylpiperidino)propanamide]; N,N''-(acridine-3,6-diyl)bis(3-(4-benzylpiperidin-1-yl)propanamide)
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
N,N'-(9,10-Dihydro-9,10-dioxoanthracene-2,6-diyl)bis[3-(octahydroazocine-1-yl)propanamide]
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL8706439; CHEMBL3707073
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| Activity |
IC50 ~ 50000 nM
|
[11] | |||
| Compound Name |
3-Morpholin-4-yl-N-[5-(3-morpholin-4-yl-propionylamino)-9,10-dioxo-9,10-dihydro-anthracen-1-yl]-propionamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL144411; BDBM50068331
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|
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| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
3-(1,3,3-Trimethyl-6-aza-bicyclo[3.2.1]oct-6-yl)-N-{6-[3-(1,3,3-trimethyl-6-aza-bicyclo[3.2.1]oct-6-yl)-propionylamino]-acridin-3-yl}-propionamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL79536; BDBM50080846; 3,6-Bis[3-(1,3,3-trimethyl-6-azabicyclo[3.2.1]octano)-propionamido)acridine
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| Activity |
IC50 ~ 50000 nM
|
[11] | |||
| Compound Name |
3-(1,7,7-Trimethyl-3-azabicyclo[3.3.1]nonan-3-yl)-N-[6-[3-(1,7,7-trimethyl-3-azabicyclo[3.3.1]nonan-3-yl)propanoylamino]acridin-3-yl]propanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1078127; BDBM50310885; N,N''-(acridine-3,6-diyl)bis(3-(1,7,7-trimethyl-3-azabicyclo[3.3.1]nonan-3-yl)propanamide)
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
Acetic acid;N-[9,10-dioxo-6-[(2-piperidin-1-ylacetyl)amino]anthracen-2-yl]-2-piperidin-1-ylacetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL419381
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| Activity |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
3-Morpholin-4-yl-N-[7-(3-morpholin-4-yl-propionylamino)-9,10-dioxo-9,10-dihydro-anthracen-2-yl]-propionamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL91898; BDBM50068340
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
Acetic acid;2-morpholin-4-yl-N-[6-[(2-morpholin-4-ylacetyl)amino]-9,10-dioxoanthracen-2-yl]acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL111206
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| Activity |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
6-Formyl-pyridine-2-carbothioic acid 2,4,6-trichloro-phenyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL351136; SCHEMBL6826433; BDBM50124737; 6-Formylpyridine-2-thiocarboxylic acid S-(2,4,6-trichlorophenyl) ester
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| Activity |
IC50 = 50000 nM
|
[12] | |||
| Compound Name |
N-[9,10-Dioxo-6-[3-(1,3,3-trimethyl-6-azabicyclo[3.2.1]octan-6-yl)propanoylamino]anthracen-2-yl]-3-(1,3,3-trimethyl-6-azabicyclo[3.2.1]octan-6-yl)propanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3707074
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| Activity |
IC50 ~ 50000 nM
|
[11] | |||
| Compound Name |
Acetic acid;3-morpholin-4-yl-N-[6-(3-morpholin-4-ylpropanoylamino)-9,10-dioxoanthracen-2-yl]propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL109388
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| Activity |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
Acetic acid;3-(dipropylamino)-N-[6-[3-(dipropylamino)propanoylamino]-9,10-dioxoanthracen-2-yl]propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL111785
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| Activity |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
1,3-Bis(3-(4-(2-(pyrrolidin-1-yl)acetamido)phenylcarbamoyl)phenyl)urea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL508572; SCHEMBL4786624; BDBM50246816
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| Activity |
EC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
2-(4-Chlorophenoxy)-1-[3-(2-hydroxyphenyl)-5-methyl-3,4-dihydropyrazol-2-yl]ethanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3787238; BDBM50160382
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| Activity |
IC50 = 54360 nM
|
[13] | |||
| Compound Name |
1-[3-(3,4-Dihydro-2H-1,5-benzodioxepin-7-yl)-5-(4-methylphenyl)-3,4-dihydropyrazol-2-yl]ethanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2333204; BDBM50428957
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| Activity |
IC50 = 54900 nM
|
[14] | |||
| Compound Name |
6-Formylpyridine-2-thiocarboxylic acid S-(4-bromophenyl) ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL155734; SCHEMBL6826112; BDBM50124742; 6-Formyl-pyridine-2-carbothioic acid S-(4-bromo-phenyl) ester
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| Activity |
IC50 = 56000 nM
|
[12] | |||
| Compound Name |
3-[2-[2-(4-Chloropiperidin-1-yl)acetyl]-3-phenyl-3,4-dihydropyrazol-5-yl]chromen-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3786111; BDBM50160390
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| Activity |
IC50 = 57790 nM
|
[13] | |||
| Compound Name |
4-Bromo-2-[5-methyl-2-[4-(trifluoromethyl)phenyl]sulfonyl-3,4-dihydropyrazol-3-yl]phenol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3780707; BDBM50152101
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| Activity |
IC50 ~ 60000 nM
|
[15] | |||
| Compound Name |
12-[[2-[1-[2-(5-Chloroindol-1-yl)ethyl]indol-3-yl]acetyl]amino]dodecyl phenyl hydrogen phosphate;N,N-diethylethanamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL155030
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| Activity |
IC50 = 61000 nM
|
[9] | |||
| Compound Name |
12-(1,1'-Ethylene-2,2'-bi[1H-indole]-3-ylacetylamino)dodecanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL157051; BDBM50097325; 12-(2-6,7-Dihydro-pyrazino[1,2-a;4,3-a'']diindol-13-yl-acetylamino)-dodecanoic acid
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| Activity |
IC50 = 62000 nM
|
[9] | |||
| Compound Name |
6-Formyl-pyridine-2-carbothioic acid 3,5-dichloro-phenyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL157889; SCHEMBL6829564; BDBM50124731; 6-Formylpyridine-2-thiocarboxylic acid S-(3,5-dichlorophenyl) ester
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| Activity |
IC50 = 64000 nM
|
[12] | |||
| Compound Name |
6-Formylpyridine-2-thiocarboxylic acid S-(4-fluorophenyl) ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL347642; SCHEMBL6831125; BDBM50124727; 6-Formyl-pyridine-2-carbothioic acid S-(4-fluoro-phenyl) ester
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| Activity |
IC50 = 64000 nM
|
[12] | |||
| Compound Name |
Costunolide
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Investigative | Compound Info | ||
| Synonyms |
(+)-costunolide; Costunlide; Costunolid; Costus lactone; Costundide; CHEMBL86416; (E,E)-6-alpha-Hydroxygermacra-1(10),4,11(13)-trien-12-oic acid gamma-lactone; (10S,1R)-3,7-dimethyl-11-methylene-13-oxabicyclo[8.3.0]trideca-2,6-dien-12-one; (E,E)-germacra-1(10),4,11(13)-trien-12-oic acid, 6-alpha-hydroxy-gamma-lactone; melampolide; NSC106404; Costunolide,(S); PubChem6258; SCHEMBL92714; Costunolide, >=97% (HPLC); HMS3269I17; HMS3413B19; HMS3677B19; HY-N0036; BDBM50411242; MFCD00210262; ZINC30726859; AKOS015840065; AKOS015969714; CS-1487; MCULE-2058016705; NCGC00381718-02; AC-28334; AS-17708; V1471; C09382; 553C219; Q5175227; BRD-K26833429-001-01-0
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| Activity |
IC50 = 65000 nM
|
[2] | |||
| Compound Name |
12-[1-[3-(Cyclohexyloxy)propyl]-1H-indole-3-ylacetylamino]dodecanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL155151; BDBM50097317; 12-{2-[1-(3-Cyclohexyloxy-propyl)-1H-indol-3-yl]-acetylamino}-dodecanoic acid
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| Activity |
IC50 = 67000 nM
|
[9] | |||
| Compound Name |
6-Formyl-pyridine-2-carbothioic acid S-(2,5-dichloro-phenyl) ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL157229; SCHEMBL6829046; BDBM50124741; 6-Formylpyridine-2-thiocarboxylic acid S-(2,5-dichlorophenyl) ester
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| Activity |
IC50 = 68000 nM
|
[12] | |||
| Compound Name |
1-[3-(3,4-Dihydro-2H-1,5-benzodioxepin-7-yl)-5-phenyl-3,4-dihydropyrazol-2-yl]ethanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2333218; BDBM50428956
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| Activity |
IC50 = 68233.87 nM
|
[14] | |||
| Compound Name |
6-Formyl-pyridine-2-carbothioic acid S-(3,4-difluoro-phenyl) ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL156248; SCHEMBL6829640; BDBM50124736; 6-Formylpyridine-2-thiocarboxylic acid S-(3,4-difluorophenyl) ester
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| Activity |
IC50 = 69000 nM
|
[12] | |||
| Compound Name |
12-[[2-[1-[2-(5-Chloroindol-1-yl)ethyl]indol-3-yl]acetyl]amino]dodecyl (3-chlorophenyl) hydrogen phosphate;N,N-diethylethanamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL351995
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| Activity |
IC50 = 70000 nM
|
[9] | |||
| Compound Name |
6-Formylpyridine-2-thiocarboxylic acid S-(4-nitrophenyl) ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL345370; SCHEMBL6830044; BDBM50124730; 6-Formyl-pyridine-2-carbothioic acid S-(4-nitro-phenyl) ester
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||||
| Activity |
IC50 = 75000 nM
|
[12] | |||
| Compound Name |
6-Formyl-pyridine-2-carbothioic acid S-m-tolyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL158024; SCHEMBL6828762; BDBM50124729; 6-Formylpyridine-2-thiocarboxylic acid S-(3-methylphenyl) ester
Click to Show/Hide
|
||||
| Activity |
IC50 = 76000 nM
|
[12] | |||
| Compound Name |
6-Formylpyridine-2-thiocarboxylic acid S-(3-methoxyphenyl) ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL156403; SCHEMBL6829714; BDBM50124733; 6-Formyl-pyridine-2-carbothioic acid S-(3-methoxy-phenyl) ester
Click to Show/Hide
|
||||
| Activity |
IC50 = 76000 nM
|
[12] | |||
| Compound Name |
1-[5-(4-Bromophenyl)-3-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)-3,4-dihydropyrazol-2-yl]ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2333203; BDBM50428955
Click to Show/Hide
|
||||
| Activity |
IC50 = 76383.58 nM
|
[14] | |||
| Compound Name |
2-(2,6-Dichloro-benzylsulfanyl)-6-formyl-nicotinonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL160642; BDBM50124726; 2-(2,6-Dichlorobenzylthio)-6-formyl-3-pyridinecarbonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 = 77000 nM
|
[12] | |||
| Compound Name |
6-Formyl-pyridine-2-carbothioic acid 2,6-dichloro-phenyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL440737; SCHEMBL6831258; BDBM50124739; 6-Formylpyridine-2-thiocarboxylic acid S-(2,6-dichlorophenyl) ester
Click to Show/Hide
|
||||
| Activity |
IC50 = 79000 nM
|
[12] | |||
| Compound Name |
6-Formylpyridine-2-thiocarboxylic acid S-(3-chlorophenyl) ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL154764; SCHEMBL6826178; BDBM50124743; 6-Formyl-pyridine-2-carbothioic acid S-(3-chloro-phenyl) ester
Click to Show/Hide
|
||||
| Activity |
IC50 = 79000 nM
|
[12] | |||
| Compound Name |
(3-Chlorophenyl) 12-[[2-[1-[3-(3-methylindol-1-yl)propyl]indol-3-yl]acetyl]amino]dodecyl hydrogen phosphate;N,N-diethylethanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL413033
Click to Show/Hide
|
||||
| Activity |
IC50 = 79000 nM
|
[9] | |||
| Compound Name |
1-[5-(4-Chlorophenyl)-3-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)-3,4-dihydropyrazol-2-yl]ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2333202; BDBM50428954
Click to Show/Hide
|
||||
| Activity |
IC50 = 82600 nM
|
[14] | |||
| Compound Name |
1-[3-(3,4-Dihydro-2H-1,5-benzodioxepin-7-yl)-5-(4-fluorophenyl)-3,4-dihydropyrazol-2-yl]ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2333201; BDBM50428953
Click to Show/Hide
|
||||
| Activity |
IC50 = 83560.3 nM
|
[14] | |||
| Compound Name |
6-Formylpyridine-2-thiocarboxylic acid S-(2-chlorophenyl) ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL345606; SCHEMBL6828814; BDBM50124740; 6-Formyl-pyridine-2-carbothioic acid S-(2-chloro-phenyl) ester
Click to Show/Hide
|
||||
| Activity |
IC50 = 84000 nM
|
[12] | |||
| Compound Name |
2-Methyl-5-propyl-4-[(3,4,5-trimethoxybenzoyl)amino]pyrazole-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3397659; BDBM50062609
Click to Show/Hide
|
||||
| Activity |
IC50 = 87000 nM
|
[16] | |||
| Compound Name |
12-[[(2R)-2-Acetamido-3-(1H-indol-3-yl)propanoyl]amino]dodecyl (2-chlorophenyl) hydrogen phosphate;N,N-diethylethanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL84794
Click to Show/Hide
|
||||
| Activity |
IC50 = 90700 nM
|
[17] | |||
| Compound Name |
6-Formylpyridine-2-thiocarboxylic acid S-(4-methoxyphenyl) ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL156121; SCHEMBL6829690; BDBM50124728; 6-Formyl-pyridine-2-carbothioic acid S-(4-methoxy-phenyl) ester
Click to Show/Hide
|
||||
| Activity |
IC50 = 91000 nM
|
[12] | |||
| Compound Name |
12-[1-[3-(1H-Indole-1-yl)propyl]-1H-indole-3-ylacetylamino]dodecanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL349537; BDBM50097329; 12-{2-[1-(3-Indol-1-yl-propyl)-1H-indol-3-yl]-acetylamino}-dodecanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 92000 nM
|
[9] | |||
| Compound Name |
1-[3-(3,4-Dihydro-2H-1,5-benzodioxepin-7-yl)-5-(4-nitrophenyl)-3,4-dihydropyrazol-2-yl]ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2333206; BDBM50428952
Click to Show/Hide
|
||||
| Activity |
IC50 = 93110.79 nM
|
[14] | |||
| Compound Name |
6-Formyl-pyridine-2-carbothioic acid S-p-tolyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL158129; BDBM50124738; 6-Formylpyridine-2-thiocarboxylic acid S-(4-methylphenyl) ester
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
N-(3,4-Dichlorophenyl)-6-formylpyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL421835; SCHEMBL6925421; BDBM50124744; 6-Formyl-pyridine-2-carboxylic acid (3,4-dichloro-phenyl)-amide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
Tert-butyl N-[(2S)-1-[[(2R)-1-[[4-[[2-[6-[(2-chlorophenoxy)-hydroxyphosphoryl]oxyhexylamino]-2-oxoethyl]amino]-4-oxobutyl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-indol-2-yl)-1-oxopropan-2-yl]carbamate;N,N-diethylethanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL407131
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
Benzyl N-[(2R)-1-[12-[(2-chlorophenoxy)-hydroxyphosphoryl]oxydodecylamino]-1-oxo-3-phenylpropan-2-yl]carbamate;N,N-diethylethanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL86404
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
6-[[2-[4-[[(2S)-2-[[(2R)-2-Amino-3-(1H-indol-2-yl)propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]butanoylamino]acetyl]amino]hexyl (2-chlorophenyl) hydrogen phosphate;N,N-diethylethanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL316111
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
12-[[(2R)-2-[[(2S)-2-Amino-3-phenylpropanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]dodecyl (2-chlorophenyl) hydrogen phosphate;N,N-diethylethanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL315431
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
(2-Chlorophenyl) 2-[2-[2-[2-[[2-[1-[3-(3-methylindol-1-yl)propyl]indol-3-yl]acetyl]amino]ethoxy]ethoxy]ethoxy]ethyl hydrogen phosphate;N,N-diethylethanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL430453
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
6-Formyl-pyridine-2-carbothioic acid S-(2-methoxy-phenyl) ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL155523; BDBM50124724; 6-Formylpyridine-2-thiocarboxylic acid S-(2-methoxyphenyl) ester
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
Tert-butyl N-[(2R)-1-[[(2R)-1-[[4-[[2-[6-[(2-chlorophenoxy)-hydroxyphosphoryl]oxyhexylamino]-2-oxoethyl]amino]-4-oxobutyl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-indol-2-yl)-1-oxopropan-2-yl]carbamate;N,N-diethylethanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL274683
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
12-(2,2'-Bi[1H-indole]-3-yloxyacetylamino)dodecanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL157172; BDBM50097319; 12-[2-(1H,1''H-[2,2'']Biindolyl-3-yloxy)-acetylamino]-dodecanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
6-[[2-[4-[[(2R)-2-[[(2S)-2-Amino-3-(1H-indol-2-yl)propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]butanoylamino]acetyl]amino]hexyl (2-chlorophenyl) hydrogen phosphate;N,N-diethylethanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL86385
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
Tert-butyl N-[(2S)-1-[[(2R)-1-[12-[(2-chlorophenoxy)-hydroxyphosphoryl]oxydodecylamino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamate;N,N-diethylethanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL314161
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
Phosphoric acid 12-[1-[3-(3-methyl-1H-indole-1-yl)propyl]-1H-indole-3-ylacetylamino]dodecyl 2-cyanoethyl 3-chlorophenyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL346776; BDBM50097330
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
(2-Chlorophenyl) 12-[[(2R)-3-(1H-indol-3-yl)-2-[[(2R)-pyrrolidine-2-carbonyl]amino]propanoyl]amino]dodecyl hydrogen phosphate;N,N-diethylethanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL313345
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
6-[[2-[4-[[(2R)-2-[[(2R)-2-Amino-3-(1H-indol-2-yl)propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]butanoylamino]acetyl]amino]hexyl (2-chlorophenyl) hydrogen phosphate;N,N-diethylethanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL87554
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
(4R)-5-[[(2R)-1-[12-[(2-Chlorophenoxy)-hydroxyphosphoryl]oxydodecylamino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-4-[(2-methylpropan-2-yl)oxycarbonylamino]-5-oxopentanoic acid;N,N-diethylethanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL315220
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
6-[[2-[4-[[(2S)-2-[[(2S)-2-Amino-3-(1H-indol-2-yl)propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]butanoylamino]acetyl]amino]hexyl (2-chlorophenyl) hydrogen phosphate;N,N-diethylethanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL83234
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
Tert-butyl N-[(2S)-1-[[(2S)-1-[[4-[[2-[6-[(2-chlorophenoxy)-hydroxyphosphoryl]oxyhexylamino]-2-oxoethyl]amino]-4-oxobutyl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-indol-2-yl)-1-oxopropan-2-yl]carbamate;N,N-diethylethanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL384288
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
6-Formyl-pyridine-2-carboxylic acid 3,4-dichloro-phenyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL156250; SCHEMBL6828668; BDBM50124746; 6-Formyl-pyridine 2-carboxylic acid 3,4-dichlorophenyl ester
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
Tert-butyl N-[(2R)-1-[[(2S)-1-[[4-[[2-[6-[(2-chlorophenoxy)-hydroxyphosphoryl]oxyhexylamino]-2-oxoethyl]amino]-4-oxobutyl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-indol-2-yl)-1-oxopropan-2-yl]carbamate;N,N-diethylethanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL266842
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
6-Formyl-pyridine-2-carbothioic acid S-(4-acetylamino-phenyl) ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL155908; SCHEMBL6829201; BDBM50124735; 6-Formylpyridine-2-thiocarboxylic acid S-[4-(acetylamino)phenyl] ester
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
12-[[2-[1-[2-(5-Chloroindol-1-yl)ethyl]indol-3-yl]acetyl]amino]dodecyl 2-cyanoethyl hydrogen phosphate;N,N-diethylethanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL153853
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
(2-Chlorophenyl) 6-[[2-[4-[[2-[1-[3-(3-methylindol-1-yl)propyl]indol-3-yl]acetyl]amino]butanoylamino]acetyl]amino]hexyl hydrogen phosphate;N,N-diethylethanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL315683
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
12-[1-[3-(1-Pyrrolyl)propyl]-1H-indole-3-ylacetylamino]dodecanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL155302; BDBM50097315; 12-{2-[1-(3-Pyrrol-1-yl-propyl)-1H-indol-3-yl]-acetylamino}-dodecanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
6-Formyl-pyridine-2-carbothioic acid S-o-tolyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL156703; SCHEMBL6828872; BDBM50124732; 6-Formylpyridine-2-thiocarboxylic acid S-(2-methylphenyl) ester
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
12-[1-[2-(3-Methyl-1H-indole-1-yl)ethyl]-1H-indole-3-ylacetylamino]dodecanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL153925; BDBM50097314; 12-(2-{1-[2-(3-Methyl-indol-1-yl)-ethyl]-1H-indol-3-yl}-acetylamino)-dodecanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
Tert-butyl N-[(2S)-1-[[(2R)-1-[12-[(2-chlorophenoxy)-hydroxyphosphoryl]oxydodecylamino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-indol-2-yl)-1-oxopropan-2-yl]carbamate;N,N-diethylethanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL85434
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
Phosphoric acid 12-[1-[2-(5-chloro-1H-indole-1-yl)ethyl]-1H-indole-3-ylacetylamino]dodecyl 2-cyanoethyl 3-chlorophenyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL154719; BDBM50097333
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
12-{2-[1-(3-Pyrrolidin-1-yl-propyl)-1H-indol-3-yl]-acetylamino}-dodecanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL157387; BDBM50097331; 12-[1-(3-Pyrrolizinopropyl)-1H-indole-3-ylacetylamino]dodecanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
Tert-butyl N-[(2R)-1-[6-[(2-chlorophenoxy)-hydroxyphosphoryl]oxyhexylamino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]carbamate;N,N-diethylethanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL314847
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
Tert-butyl N-[(2R)-1-[[(2S)-1-[12-[(2-chlorophenoxy)-hydroxyphosphoryl]oxydodecylamino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-indol-2-yl)-1-oxopropan-2-yl]carbamate;N,N-diethylethanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL421541
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
6-[[(2R)-2-Amino-3-(1H-indol-3-yl)propanoyl]amino]hexyl (2-chlorophenyl) hydrogen phosphate;N,N-diethylethanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL313922
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
(4R)-4-Amino-5-[[(2R)-1-[12-[(2-chlorophenoxy)-hydroxyphosphoryl]oxydodecylamino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid;N,N-diethylethanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL313673
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
12-[[2-[1-[2-(5-Chloroindol-1-yl)ethyl]indol-3-yl]acetyl]amino]dodecyl cyclohexyl hydrogen phosphate;N,N-diethylethanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL345715
Click to Show/Hide
|
||||
| Activity |
IC50 = 101000 nM
|
[9] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 10 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Camptothecin
Click to Show/Hide
|
Phase 3 | Compound Info | ||
| Synonyms |
camptothecin; Camptothecine; 7689-03-4; (S)-(+)-Camptothecin; Campathecin; d-Camptothecin; (+)-Camptothecine; (+)-Camptothecin; 20(S)-Camptothecine; 21,22-Secocamptothecin-21-oic acid lactone; NSC94600; (S)-Camptothecin; Camptothecine (8CI); 20(S)-Camptothecin; Camptothecine (S,+); CHEMBL65; UNII-XT3Z54Z28A; MLS000766223; (4S)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; XT3Z54Z28A; CHEBI:27656; VSJKWCGYPAHWDS-FQEVSTJZSA-N; Camptothecin, Camptotheca acuminata; NSC-94600; Camptothecin derivat
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[1] | |||
| Compound Name |
TOPOSTATIN
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
topostatin; CHEMBL505529
Click to Show/Hide
|
||||
| Activity |
IC50 > 250000 nM
|
[1] | |||
| Compound Name |
Collinomycin
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
alpha-Rubromycin; UNII-5XEO5ZD7XP; .alpha.-Rubromycin; 5XEO5ZD7XP; Rubromycin; Tuoromycin; SCHEMBL2141952; CHEMBL3347655; DTXSID60930430; Q27263008; Naphtho[2,3-b]furan, 1H-2-benzopyran-3-carboxylic acid deriv.; 6-[2-(4,9-Dihydro-8-hydroxy-5,7-dimethoxy-4,9-dioxonaphtho[2,3-b]furan-2-yl)
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[2] | |||
| Compound Name |
3-[(E)-4-Hydroxybenzylidene]-6-hydroxybenzofuran-2(3H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL195416; SCHEMBL15426107; BDBM50164888; 6-Hydroxy-3-[1-(4-hydroxy-phenyl)-meth-(E)-ylidene]-3H-benzofuran-2-one
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| Activity |
IC50 > 400000 nM
|
[1] | |||
| Compound Name |
Altertoxin I
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Investigative | Compound Info | ||
| Synonyms |
Altertoxin-I; CCRIS 2190; CHEMBL521470; SCHEMBL22837286; DTXSID40971689; HY-N6724; ZINC6092274; BDBM50479261; MCULE-6504405710; CS-0085164; 1,4,9,12a-Tetrahydroxy-1,2,11,12,12a,12b-hexahydroperylene-3,10-dione
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| Activity |
IC50 > 1000000 nM
|
[2] | |||
| Compound Name |
3-Amino-8-(4-amidinophenylazoamino)-6-phenyl-5-ethylphenanthridine-5-ium
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2260104; BDBM50487896
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| Activity |
IC50 = 18197008.59 nM
|
[18] | |||
| Compound Name |
Isometamidium
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Investigative | Compound Info | ||
| Synonyms |
Samorin; UNII-S9HA0WUW3H; Trypamidium; S9HA0WUW3H; SCHEMBL913500; CHEMBL2111043; SCHEMBL17679335; CTK5C7059; DTXSID30174384; ZINC4216649; BDBM50440390; AKOS030242652; Q27289082; Phenanthridinium, 8-(3-(m-amidinophenyl)-2-triazenol-3-amino-5-phenyl-
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| Activity |
IC50 = 19054607.18 nM
|
[18] | |||
| Compound Name |
3-N-(2-Amino-1,6-dimethylpyrimidin-1-ium-4-yl)-5-methyl-6-(4-methylphenyl)phenanthridin-5-ium-3,8-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2260106; BDBM50487898
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| Activity |
IC50 = 46773514.13 nM
|
[18] | |||
| Compound Name |
3-[(3,8-Diamino-5-ethyl-6-phenylphenanthridin-5-ium-7-yl)diazenyl]benzenecarboximidamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2260105; BDBM50487895; M&B-4250
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| Activity |
IC50 = 97723722.1 nM
|
[18] | |||
| Compound Name |
3,11-Difluoro-6,8,13-trimethyl-8H-quino[4,3,2-KL]acridin-13-ium
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL158083; RHPS-4; CHEMBL1181174; SCHEMBL15722798; ZINC1551456; BDBM50108802; Q27462485; 3,11-difluoro-6,8,13-trimethyl-8H-quino[4,3,2-kl]acridin-13-ium; methyl sulfate(RHPS4)
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| Activity |
IC50 = 331131121.5 nM
|
[18] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
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| REF 2 | Natural products targeting telomere maintenance. Medchemcomm. 2011;2:229-45. | ||||
| REF 3 | Rational design of substituted diarylureas: a scaffold for binding to G-quadruplex motifs. J Med Chem. 2008 Dec 25;51(24):7751-67. | ||||
| REF 4 | 2,7-Disubstituted amidofluorenone derivatives as inhibitors of human telomerase. J Med Chem. 1999 Jul 15;42(14):2679-84. | ||||
| REF 5 | Prediction of telomerase inhibitory activity for acridinic derivatives based on chemical structure. Eur J Med Chem. 2009 Dec;44(12):4826-40. | ||||
| REF 6 | New quinazoline derivatives for telomeric G-quadruplex DNA: effects of an added phenyl group on quadruplex binding ability. Eur J Med Chem. 2013 May;63:1-13. | ||||
| REF 7 | Human telomerase inhibition by regioisomeric disubstituted amidoanthracene-9,10-diones. J Med Chem. 1998 Nov 19;41(24):4873-84. | ||||
| REF 8 | 1,4- and 2,6-disubstituted amidoanthracene-9,10-dione derivatives as inhibitors of human telomerase. J Med Chem. 1998 Aug 13;41(17):3253-60. | ||||
| REF 9 | Development of novel telomerase inhibitors based on a bisindole unit. Bioorg Med Chem Lett. 2001 Feb 26;11(4):583-5. | ||||
| REF 10 | Catecholic flavonoids acting as telomerase inhibitors. J Med Chem. 2004 Dec 16;47(26):6466-75. | ||||
| REF 11 | Molecular modeling studies on G-quadruplex complexes of telomerase inhibitors: structure-activity relationships. J Med Chem. 1999 Nov 4;42(22):4538-46. | ||||
| REF 12 | Synthesis of 6-formyl-pyridine-2-carboxylate derivatives and their telomerase inhibitory activities. Bioorg Med Chem Lett. 2003 Feb 24;13(4):609-12. | ||||
| REF 13 | Dihydropyrazole derivatives as telomerase inhibitors: Structure-based design, synthesis, SAR and anticancer evaluation in vitro and in vivo. Eur J Med Chem. 2016 Apr 13;112:231-251. | ||||
| REF 14 | Synthesis, biological evaluation, 3D-QSAR studies of novel aryl-2H-pyrazole derivatives as telomerase inhibitors. Bioorg Med Chem Lett. 2013 Feb 15;23(4):1091-5. | ||||
| REF 15 | Identification of human telomerase inhibitors having the core of N-acyl-4,5-dihydropyrazole with anticancer effects. Bioorg Med Chem Lett. 2016 Mar 15;26(6):1508-1511. | ||||
| REF 16 | Novel pyrazole-5-carboxamide and pyrazole-pyrimidine derivatives: synthesis and anticancer activity. Eur J Med Chem. 2015 Jan 27;90:889-96. | ||||
| REF 17 | Solid-Phase synthesis of a library constructed of aromatic phosphate, long alkyl chains and tryptophane components, and identification of potent dipeptide telomerase inhibitors. Bioorg Med Chem Lett. 2001 Oct 8;11(19):2581-4. | ||||
| REF 18 | QSAR and pharmacophore studies of telomerase inhibitors. Med Chem Res. 2011 Feb 18;21:853-66. | ||||
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