Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T86273 | Target Info | |||
| Target Name | G-protein coupled bile acid receptor 1 (GPBAR1) | ||||
| Synonyms |
hGPCR19; hBG37; TGR5; Membrane-type receptor for bile acids; M-BAR; G-protein coupled receptor GPCR19; BG37
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| Target Type | Clinical trial Target | ||||
| Gene Name | GPBAR1 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 45 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
tauroursodeoxycholic acid
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|
Investigative | Compound Info | ||
| Synonyms |
tauroursodeoxycholate; TUDCA
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| Activity |
EC50 = 50500 nM
|
[1] | |||
| Compound Name |
[2-[(2-Chloro-6-fluorophenyl)methylsulfanyl]-4-(4-chloro-3-methoxyphenyl)-3-(4-fluorophenyl)-6,7-dihydro-5H-benzimidazol-4-yl]methanol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4064131; SCHEMBL17185839; BDBM50233514
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| Activity |
EC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
2-[(2-Bromo-6-fluorophenyl)methylsulfanyl]-7-(4-chloro-3-methoxyphenyl)-1-(4-fluorophenyl)-4,5,6,7-tetrahydrobenzimidazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4092628; SCHEMBL17196962; BDBM50233477
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| Activity |
EC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
2-[(2-Chloro-6-fluorophenyl)methylsulfanyl]-7-(2,3-dihydro-1,4-benzodioxin-6-yl)-1-(4-fluorophenyl)-4,5,6,7-tetrahydrobenzimidazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4079911; SCHEMBL17197165; BDBM50233519
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| Activity |
EC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
2-[(2-Chloro-6-fluorophenyl)methylsulfanyl]-1-(4-fluorophenyl)-7-(3-methoxyphenyl)-4,5,6,7-tetrahydrobenzimidazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4092168; SCHEMBL17197190; BDBM50233508
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| Activity |
EC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
N-[[2-[(2-Chloro-6-fluorophenyl)methylsulfanyl]-3-(4-fluorophenyl)imidazol-4-yl]methyl]-N-(3,4-dimethoxyphenyl)acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4082365; BDBM50236996
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| Activity |
EC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
2-[(2-Chloro-6-fluorophenyl)methylsulfanyl]-7-(4-chloro-3-methoxyphenyl)-7-(fluoromethyl)-1-(4-fluorophenyl)-5,6-dihydro-4H-benzimidazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4091882; SCHEMBL17197106; BDBM50233487
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|
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| Activity |
EC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
2-[(2-Chloro-6-fluorophenyl)methylsulfanyl]-7-(4-chloro-3-methoxyphenyl)-7-ethyl-1-(4-fluorophenyl)-5,6-dihydro-4H-benzimidazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4084125; SCHEMBL17197103; BDBM50233486
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| Activity |
EC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
2-[(2-Chloro-6-fluorophenyl)methylsulfanyl]-7-(4-chloro-3-methoxyphenyl)-1-(4-fluorophenyl)-4,5,6,7-tetrahydrobenzimidazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4069934; SCHEMBL17197113; BDBM50233497
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| Activity |
EC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
7-(1,3-Benzodioxol-5-yl)-2-[(2-chloro-6-fluorophenyl)methylsulfanyl]-1-(4-fluorophenyl)-4,5,6,7-tetrahydrobenzimidazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4104148; BDBM50233501
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| Activity |
EC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
2-[(2-Chloro-6-fluorophenyl)methylsulfanyl]-4-(4-fluoro-3-methoxyphenyl)-3-(4-fluorophenyl)-6,7-dihydro-4H-pyrano[3,4-d]imidazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4099616; SCHEMBL17197069; BDBM50233483
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| Activity |
EC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
N-[[2-[(2-Chloro-6-fluorophenyl)methylsulfanyl]-3-(4-fluorophenyl)imidazol-4-yl]methyl]-3,4-dimethoxyaniline
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4101321; BDBM50237004
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| Activity |
EC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
2-[(2-Chloro-6-fluorophenyl)methylsulfanyl]-7-(4-chloro-3-methoxyphenyl)-1-(4-fluoro-3-methylphenyl)-4,5,6,7-tetrahydrobenzimidazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4091129; SCHEMBL17197114; BDBM50233506
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| Activity |
EC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
2-[(2-Chloro-6-fluorophenyl)methylsulfanyl]-7-(4-chloro-3-methoxyphenyl)-1-[4-fluoro-3-(trifluoromethyl)phenyl]-4,5,6,7-tetrahydrobenzimidazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4074596; SCHEMBL17197076; BDBM50233509
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| Activity |
EC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
2-[(3-Chloro-5-fluorophenyl)methylsulfanyl]-7-(4-chloro-3-methoxyphenyl)-1-(4-fluorophenyl)-4,5,6,7-tetrahydrobenzimidazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4062174; BDBM50233481
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|
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| Activity |
EC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
2-[(2-Chloro-6-fluorophenyl)methylsulfanyl]-7-(3-chloro-4-methoxyphenyl)-1-(4-fluorophenyl)-4,5,6,7-tetrahydrobenzimidazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4069164; SCHEMBL17197149; BDBM50233502
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| Activity |
EC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
2-[(2-Chloro-6-fluorophenyl)methylsulfanyl]-7-(4-fluoro-3-methoxyphenyl)-1-(4-fluorophenyl)-4,5,6,7-tetrahydrobenzimidazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4104842; BDBM50233518
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| Activity |
EC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
3-[[4-[[5-[(3,4-Dimethoxyphenyl)sulfanylmethyl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-3,5-difluorophenyl]sulfonyl-[3-(trimethylazaniumyl)propyl]amino]propyl-trimethylazanium;2,2,2-trifluoroacetate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4078375; BDBM50236995
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|
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| Activity |
EC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
7-(4-Chloro-3-methoxyphenyl)-2-[(2,6-difluorophenyl)methylsulfanyl]-1-(4-fluorophenyl)-4,5,6,7-tetrahydrobenzimidazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4065966; SCHEMBL17185990; BDBM50233475
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|
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| Activity |
EC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
1-(3-Chloro-4-fluorophenyl)-2-[(2-chloro-6-fluorophenyl)methylsulfanyl]-7-(4-chloro-3-methoxyphenyl)-4,5,6,7-tetrahydrobenzimidazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4070183; SCHEMBL17197094; BDBM50233507
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|
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| Activity |
EC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
2-[(2-Chloro-6-fluorophenyl)methylsulfanyl]-7-(4-chloro-3-methoxyphenyl)-1-(3,4-difluorophenyl)-4,5,6,7-tetrahydrobenzimidazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4087791; SCHEMBL17197056; BDBM50233505
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|
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| Activity |
EC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
7-(4-Chloro-3-methoxyphenyl)-2-[(2-fluoro-6-nitrophenyl)methylsulfanyl]-1-(4-fluorophenyl)-4,5,6,7-tetrahydrobenzimidazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4087370; SCHEMBL17196972; BDBM50233476
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|
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| Activity |
EC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
2-[(2-Chloro-6-fluorophenyl)methylsulfanyl]-4-(4-chloro-3-methoxyphenyl)-3-(4-fluorophenyl)-6,7-dihydro-4H-pyrano[3,4-d]imidazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4072719; SCHEMBL17197085; BDBM50233482
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|
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| Activity |
EC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
2-[[4-[[5-[(3,4-Dimethoxyphenyl)sulfanylmethyl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-3,5-difluorobenzoyl]amino]ethyl-trimethylazanium;chloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4083747; BDBM50237001
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|
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| Activity |
EC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
7-(4-Chloro-3-methoxyphenyl)-2-[(2-fluoro-6-methoxyphenyl)methylsulfanyl]-1-(4-fluorophenyl)-4,5,6,7-tetrahydrobenzimidazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4064931; SCHEMBL17196961; BDBM50233511
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| Activity |
EC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
7-(4-Chloro-3-methoxyphenyl)-2-[(2,5-difluorophenyl)methylsulfanyl]-1-(4-fluorophenyl)-4,5,6,7-tetrahydrobenzimidazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4084863; SCHEMBL17196960; BDBM50233478
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|
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| Activity |
EC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
2-[(2-Chloro-6-fluorophenyl)methylsulfanyl]-7-(4-chloro-3-methoxyphenyl)-1-(4-fluorophenyl)-7-methyl-5,6-dihydro-4H-benzimidazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4083189; SCHEMBL17197168; BDBM50233484
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| Activity |
EC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
2-[(2-Chloro-6-fluorophenyl)methylsulfanyl]-7-(4-chloro-3-methoxyphenyl)-1-(4-methoxyphenyl)-4,5,6,7-tetrahydrobenzimidazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4095497; SCHEMBL17196952; BDBM50233503
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| Activity |
EC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
(7R)-2-[(2-Chloro-6-fluorophenyl)methylsulfanyl]-7-(3,4-dimethoxyphenyl)-1-(4-fluorophenyl)-4,5,6,7-tetrahydrobenzimidazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4065113; SCHEMBL17185909; BDBM50233500
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| Activity |
EC50 ~ 50000 nM
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[2] | |||
| Compound Name |
7-(4-Chloro-3-methoxyphenyl)-2-[(2,4-difluorophenyl)methylsulfanyl]-1-(4-fluorophenyl)-4,5,6,7-tetrahydrobenzimidazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4102817; BDBM50233480
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| Activity |
EC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
2-[(2-Chloro-6-fluorophenyl)methylsulfanyl]-7-(4-chloro-3-methoxyphenyl)-1-(4-chlorophenyl)-4,5,6,7-tetrahydrobenzimidazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4075062; BDBM50233504
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| Activity |
EC50 ~ 50000 nM
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[2] | |||
| Compound Name |
4-[[5-[(3,4-Dimethoxyphenyl)sulfanylmethyl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-3,5-difluorobenzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4071870; BDBM50236998
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| Activity |
EC50 ~ 50000 nM
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[3] | |||
| Compound Name |
4-[[5-[(3,4-Dimethoxyphenyl)sulfanylmethyl]-1-(4-fluorophenyl)imidazol-2-yl]sulfinylmethyl]-3,5-difluorobenzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4102235; BDBM50237007
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| Activity |
EC50 ~ 50000 nM
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[3] | |||
| Compound Name |
(2R,4R)-2-Methyl-4-[(3R,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL388679
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| Activity |
EC50 ~ 51900 nM
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[4] | |||
| Compound Name |
[(E)-3-Phenylprop-2-enyl] N-[(3R)-3-[(3R,5S,6R,7R,8S,9S,10S,13R,14S,17R)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]butyl]carbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1765565; BDBM50342396; 23-N-(carbocinnamyloxy)-3alpha,7alpha-dihydroxy-6alpha-ethyl-24-nor-5beta-cholan-23-amine
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| Activity |
EC50 = 55000 nM
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[5] | |||
| Compound Name |
(22R,23R)-3alpha,7alpha-Dihydroxy-22,23-methylene-5beta-cholan-24-oic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL409510; SCHEMBL592441; BDBM50375569
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| Activity |
EC50 = 75700 nM
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[6] | |||
| Compound Name |
(3S)-N-[2-(4-Chlorophenyl)ethyl]-1-pyrimidin-2-ylpiperidine-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3234548; BDBM50003564
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| Activity |
EC50 ~ 80000 nM
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[7] | |||
| Compound Name |
6alpha-Ethyl-Avicholic Acid Sodium Salt
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2062553
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| Activity |
EC50 = 87000 nM
|
[8] | |||
| Compound Name |
[(E)-3-Phenylprop-2-enyl] N-[(3R)-3-[(3R,7R,8R,9S,10S,13R,14S)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]butyl]carbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3138092; BDBM50002614
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| Activity |
EC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
(1S,2R)-2-[(1R)-1-[(3R,5S,7R,8R,9S,10S,13R,14S,17R)-3,7-Dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethyl]cyclopropane-1-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL270912; SCHEMBL593353; BDBM50375568
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| Activity |
EC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
Sulfolithocholic acid
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Investigative | Compound Info | ||
| Synonyms |
lithocholic acid sulfate; lithocholic acid 3-sulfate; UNII-0ENK5NMI1I; 0ENK5NMI1I; 3a-Sulfooxy-5b-cholanic acid; 3alpha-sulfooxy-5beta-cholan-24-oic acid; CHEMBL260315; (3alpha,5beta)-3-(sulfooxy)cholan-24-oic acid; Lithocholic acid 3-alpha-sulfate; Lithocholic acid, 3-sulfate; SCHEMBL232940; CTK4H2814; Cholan-24-oic acid, 3-(sulfooxy)-, (3a-alpha,5-beta)-; BDBM50375583; LMST05020015; ZINC12494532; (3a,5b)-3-(Sulfooxy)cholan-24-oic acid; Cholan-24-oic acid,3-(sulfooxy)-, (3a,5b)-; Q27116471; 3-Hydroxy-cholan-24-oic acid, 3-sulfate (3-.alpha., 5-.beta.)
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| Activity |
EC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
Dinorchenodeoxycholic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL272409; 24-dinor-3alpha,7alpha-dihydroxy-5beta-cholan-22-oic acid; BDBM50375572; LMST04050007; 3alpha,7alpha-Dihydroxy-23,24-dinor-5beta-cholan-22-oic acid
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| Activity |
EC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
(3beta,5beta,9beta)-3-(Acetyloxy)cholan-24-Oic Acid
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Investigative | Compound Info | ||
| Synonyms |
lithocholic acid acetate; CHEMBL272041; Lithocholic acid 3-acetate; ACETYLLITHOCHOLIC ACID; SCHEMBL678540; 3alpha-Acetoxy-5beta-cholanic acid; BDBM50375582; ZINC28536877; 3-(Acetyloxy)cholan-24-oic acid #; 3alpha-acetoxy-5beta-cholan-24-oic acid; Q27462645
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| Activity |
EC50 ~ 102000 nM
|
[6] | |||
| Compound Name |
Dehydroepiandrosterone sulfate
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Investigative | Compound Info | ||
| Synonyms |
Prasterone sulfate; DHEA sulfate; Dehydroisoandrosterone sulfate; DHEAS; Dehydroepiandrosterone sulphate; Dehydroepiandrosterone monosulfate; 3-O-Sulfodehydroepiandrosterone; Dehydroandrosterone sulfate; Dehydroepiandrosterone 3-sulfate; Dehydroisoandrosterone-3-sulfate; 17-Ketoandrost-5-en-3beta-yl sulfate; 3beta-Hydroxyandrost-5-en-17-one 3-sulfate; Androst-5-en-17-on-3beta-yl sulfuric acid; CCRIS 6746; DHEA-S; DHEA sulphate; Prasterone sulphate; UNII-57B09Q7FJR; (3-beta)-3-(Sulfooxy)androst-5-en-17-one; Mylis; 57B09Q7FJR; CHEMBL259898; 651-48-9 (free acid); 17-oxoandrost-5-en-3beta-yl hydrogen sulphate; Androst-5-en-17-one, 3-(sulfooxy)-, (3b)-; Androst-5-en-17-one, 3-(sulfooxy)-, (3beta)-; 17-oxoandrost-5-en-3beta-yl hydrogen sulfate; Prasterone-3-sulfate; NSC72822; Formylisoglutamic acid; 5-Androsten-3beta-sulfate-17-one; 3-beta-hydroxyandrost-5-en-17-one 3-sulfate; Inflarest; 3beta-Hydroxyandrost-5-en-17-one-3-sulfate; Prasterone-3-sulphate; Mylis (*Sodium Salt*); Teloin (*Sodium salt*); Epitope ID:150912; Lopac0_000379; SCHEMBL27640; Dehydroisoandrosterone sulphate; Androst-5-en-17-one, 3-(sulfooxy)-, (3-beta)-; PRASTERONE SULFURIC ACID; Androst-5-en-17-one, 3-(sulfooxy)-, (3.beta.)-; Dehydroepiandrosterone-3-sulfate; Androst-5-en-17-one, 3-beta-hydroxy-, hydrogen sulfate; dehydroepiandrosterone-3-sulphate; DTXSID8040228; Dehydroepiandrosterone 3-sulphate; Dehydroepiandrosterone 3beta-sulfate; ZINC4096458; 3beta-Sulfooxy-5-androsten-17-one; 5-Androsten-3-beta-sulfate-17-one; BDBM50375559; CMC_13438; LMST05020010; PB-005; Androst-5-en-17-on-3beta-yl sulfate; DB05804; Androst-5-en-17-one-3beta-yl sulfate; Androst-5-ene-17-one-3beta-yl-sulfate; 17-Oxoandrost-5-en-3-yl hydrogen sulfate; 3b-hydroxyandrost-5-en-17-one 3-sulfate; 3beta-Hydroxy-5-androsten-17-one sulfate; 17-Oxoandrost-5-en-3-yl hydrogen sulphate; 17-oxoandrost-5-en-3b-yl hydrogen sulfate; 3-b-hydroxyandrost-5-en-17-one 3-sulfate; 3b-Hydroxyandrost-5-en-17-one 3-sulphate; 17-Oxoandrost-5-en-3b-yl hydrogen sulphate; 3-b-Hydroxyandrost-5-en-17-one 3-sulphate; 3beta-Hydroxy-5-androsten-17-one 3-sulfate; (3beta)-3-(sulfooxy)-Androst-5-en-17-one; 3beta-Hydroxy-5-androsten-17-one monosulfate; 3beta-hydroxyandrost-5-en-17-one 3-sulphate; 3-beta-Hydroxyandrost-5-en-17-one 3-sulphate; C04555; 3b-hydroxy-Androst-5-en-17-one hydrogen sulfate; 3b-Hydroxy-Androst-5-en-17-one hydrogen sulphate; (3beta)-17-oxoandrost-5-en-3-yl hydrogen sulfate; 3beta-hydroxy-Androst-5-en-17-one hydrogen sulfate; Q2505402; 3beta-hydroxy-Androst-5-en-17-one hydrogen sulphate; Androst-5-en-17-one, 3-(sulfooxy)-, (3beta)- (9CI); Androst-5-en-17-one, 3beta-hydroxy-, hydrogen sulfate (6CI,8CI)
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| Activity |
EC50 = 127000 nM
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[6] | |||
| Compound Name |
Avicholic Acid Sodium Salt
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2062551
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| Activity |
EC50 = 160000 nM
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[8] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 2 non binders) | Download | Top | |||
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| Compound Name |
Dinorursodeoxycholic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1254991; 24-dinor-3alpha,7beta-dihydroxy-5beta-cholan-22-oic acid; BDBM50334959; LMST04050008
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| Activity |
EC50 > 316000 nM
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[6] | |||
| Compound Name |
(E)-4-[2,5-Dichloro-4-[3-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)pyridin-4-yl]oxyphenyl]but-3-enoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3421895; BDBM50081121
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| Activity |
EC50 = 378000 nM
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[9] | |||
| References | Top | ||||
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| REF 1 | Mutational mapping of the transmembrane binding site of the G-protein coupled receptor TGR5 and binding mode prediction of TGR5 agonists. Eur J Med Chem. 2015 Nov 2;104:57-72. | ||||
| REF 2 | Discovery of Orally Efficacious Tetrahydrobenzimidazoles as TGR5 Agonists for Type 2 Diabetes. ACS Med Chem Lett. 2017 Apr 21;8(5):560-565. | ||||
| REF 3 | Evaluation of anti-diabetic effect and gall bladder function with 2-thio-5-thiomethyl substituted imidazoles as TGR5 receptor agonists. Bioorg Med Chem Lett. 2017 Apr 15;27(8):1760-1764. | ||||
| REF 4 | Nongenomic actions of bile acids. Synthesis and preliminary characterization of 23- and 6,23-alkyl-substituted bile acid derivatives as selective modulators for the G-protein coupled receptor TGR5. J Med Chem. 2007 Sep 6;50(18):4265-8. | ||||
| REF 5 | Extending SAR of bile acids as FXR ligands: discovery of 23-N-(carbocinnamyloxy)-3alpha,7alpha-dihydroxy-6alpha-ethyl-24-nor-5-cholan-23-amine. Bioorg Med Chem. 2011 Apr 15;19(8):2650-8. | ||||
| REF 6 | Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies. J Med Chem. 2008 Mar 27;51(6):1831-41. | ||||
| REF 7 | Discovery of trifluoromethyl(pyrimidin-2-yl)azetidine-2-carboxamides as potent, orally bioavailable TGR5 (GPBAR1) agonists: structure-activity relationships, lead optimization, and chronic in vivo efficacy. J Med Chem. 2014 Apr 24;57(8):3263-82. | ||||
| REF 8 | Avicholic Acid: A Lead Compound from Birds on the Route to Potent TGR5 Modulators. ACS Med Chem Lett. 2012 Feb 6;3(4):273-7. | ||||
| REF 9 | Discovery of Intestinal Targeted TGR5 Agonists for the Treatment of Type 2 Diabetes. J Med Chem. 2015 Apr 23;58(8):3315-28. | ||||
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