Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T86385 | Target Info | |||
| Target Name | Cathepsin G (CTSG) | ||||
| Synonyms |
CG
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| Target Type | Clinical trial Target | ||||
| Gene Name | CTSG | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 62 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Sivelestat
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|
Phase 4 | Compound Info | ||
| Synonyms |
127373-66-4; UNII-DWI62G0P59; 2-[[2-[[4-(2,2-dimethylpropanoyloxy)phenyl]sulfonylamino]benzoyl]amino]acetic acid; Elastase Inhibitor IV; C20H22N2O7S; N-(2-(4-(2,2-Dimethylpropionyloxy)phenylsulfonylamino)benzoyl)aminoacetic acid; Sivelestat (ONO-5046); LY544349; CHEMBL76688; LY 544349; DWI62G0P59; Glycine, N-(2-(((4-(2,2-dimethyl-1-oxopropoxy)phenyl)sulfonyl)amino)benzoyl)-; N-(o-(p-Pivaloyloxybenzene)sulfonylaminobenzoyl)glycine
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
3,4-dichloroisocoumarin
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Investigative | Compound Info | ||
| Synonyms |
3,4-dichloroisocoumarin; 51050-59-0; 3,4-Dcl; 3,4-Dichloro-1H-isochromen-1-one; 1H-2-Benzopyran-1-one,3,4-dichloro-; 3,4-DCI; 3,4 dichloroisocoumarin; 3,4-Dichloro-1H-2-benzopyran-1-one; 1H-2-Benzopyran-1-one, 3,4-dichloro-; CHEMBL24983; 3,4-dichloroisochromen-1-one; 3,4-Dichloro-2-benzopyran-1-one; C9H4Cl2O2; Lopac-D-7910; cid_1609; AC1Q3H9V; AC1L1BU9; Lopac0_000442; KBioGR_000269; KBioSS_000269; BSPBio_001549; MLS002153325; SCHEMBL106901; 3,4-Dichloro-isochromen-1-one; KBio3_000538; KBio2_002837; CTK4J3543; KBio2_005405
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| Activity |
IC50 = 93000 nM
|
[2] | |||
| Compound Name |
Camostat mesylate
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|
Phase 2/3 Trial | Compound Info | ||
| Synonyms |
Camostat (mesylate); Camostat Methanesulfonate; Camostat methanesulfate; DSSTox_CID_238; DSSTox_GSID_20238; DSSTox_RID_75452; FOY 305; FOY-305; FOY305; Foipan; Foipan (TN); Foipan mesylate; NCGC00167526-01; Q-200778; UNII-451M50A1EQ; camostat mesilate; 451M50A1EQ; C21H26N4O8S; CAS-59721-29-8; CHEMBL85164
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(2R)-2-[[(2R)-2-[[2-[[2-[[2-[[(2S)-2-[[(1R,7S,10S,13S,16S,22S,25S,28S,40R,43S,46S,49S,52S,58S,61S)-40-Acetamido-43,52-bis(2-amino-2-oxoethyl)-13-(carboxymethyl)-46-[(1R)-1-hydroxyethyl]-10,49,61-tris(1H-indol-3-ylmethyl)-16-methyl-25-(2-methylpropyl)-2,8,11,14,17,23,26,41,44,47,50,53,59,62-tetradecaoxo-30,38,65-trithia-3,9,12,15,18,24,27,42,45,48,51,54,60,63-tetradecazahexacyclo[32.29.3.132,36.03,7.018,22.054,58]heptahexaconta-32,34,36(67)-triene-28-carbonyl]amino]propanoyl]-methylamino]acetyl]-methylamino]acetyl]-methylamino]acetyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4059991; BDBM50256261
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| Activity |
Ki ~ 50000 nM
|
[4] | |||
| Compound Name |
Trifluoroethylamine inhibitor, 2
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL400387; SCHEMBL3476615; BDBM19492
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
(2R)-2-Amino-N-[(1S,2S)-1-cyano-2-phenylcyclopropyl]-3-thiophen-2-ylpropanamide;2,2,2-trifluoroacetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL478737
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
(2S)-2-Amino-N-[(1R,2R)-1-cyano-2-phenylcyclopropyl]-3-thiophen-2-ylpropanamide;2,2,2-trifluoroacetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL516292
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
(7R,10S,13S,21S,24S,27S,30S,33S,36S,39S,42S,45R)-7-Acetamido-36-(3-amino-3-oxopropyl)-13-benzyl-24-(4-carbamimidamidobutyl)-39-(carboxymethyl)-10-(hydroxymethyl)-21-[(4-hydroxyphenyl)methyl]-33-(1H-imidazol-5-ylmethyl)-30-methyl-42-(2-methylpropyl)-8,11,14,19,22,25,28,34,37,40,43-undecaoxo-5,47,52-trithia-9,12,15,20,23,26,29,32,35,38,41,44-dodecazatetracyclo[25.23.3.13,49.015,18]tetrapentaconta-1,3(54),49-triene-45-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4094403; BDBM50256260
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| Activity |
Ki ~ 50000 nM
|
[4] | |||
| Compound Name |
cis-(S)-2-Amino-N-((1R,2R)-1-cyano-2-phenylcyclopropyl)-3-(thiophen-2-yl)propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1078411; BDBM50310690; (2S)-N-[[(1R)-1alpha-Cyano-2beta-phenylcyclopropane]-1-yl]-2-amino-3-(2-thienyl)propanamide
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
(3S)-1-Diazo-3-[(aminoacetyl)amino]-4-(4-iodophenyl)-2-butanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL450997; BDBM50270029; 2-Amino-N-[(S)-3-diazo-1-(4-iodo-benzyl)-2-oxo-propyl]-acetamide
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
(2R)-2-[[(2R)-2-[[2-[[2-[[2-[[(2S)-2-[[(7R,10S,13S,16S,22S,25S,28S,31R,34S,37S,45S,48S,51R)-51-Acetamido-45-benzyl-10-[(2S)-butan-2-yl]-34-(4-carbamimidamidobutyl)-13-(carboxymethyl)-48-(hydroxymethyl)-22,25,37-tris[(4-hydroxyphenyl)methyl]-9,12,15,21,24,27,30,33,36,39,44,47,50-tridecaoxo-28-propan-2-yl-5,53,58-trithia-8,11,14,20,23,26,29,32,35,38,43,46,49-tridecazapentacyclo[29.25.3.13,55.016,20.040,43]hexaconta-1(56),2,55(60)-triene-7-carbonyl]amino]propanoyl]-methylamino]acetyl]-methylamino]acetyl]-methylamino]acetyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4070056; BDBM50256262
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| Activity |
Ki ~ 50000 nM
|
[4] | |||
| Compound Name |
Benzyl (3aS,6aR)-6-allyl-4-(methylsulfonyl)-5-oxohexahydropyrrolo[3,2-b]pyrrole-1(2H)-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2367632; SCHEMBL6618851; BDBM50066997
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| Activity |
IC50 = 53000 nM
|
[7] | |||
| Compound Name |
2-Butyl-1-hydroxy-8-methoxyanthracene-9,10-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL43576; 9,10-Anthracenedione, 2-butyl-1-hydroxy-8-methoxy-; ACMC-20mz0p; CTK0F2112; DTXSID40658160; BDBM50005905; ZINC13454717; 2-Butyl-1-hydroxy-8-methoxy-anthraquinone; 1-Hydroxy-8-methoxy-2-butyl-9,10-anthraquinone
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| Activity |
IC50 = 55000 nM
|
[8] | |||
| Compound Name |
1,8-Dihydroxy-2-methylanthracene-9,10-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL40849; Isochrysophanol; 1,8-Dihydroxy-2-methylanthraquinone; SCHEMBL19461991; DTXSID30460239; BDBM50005890; ZINC13334406; 1,8-Dihydroxy-2-methyl-anthraquinone
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| Activity |
IC50 = 55000 nM
|
[8] | |||
| Compound Name |
2-Benzyl-1,8-dihydroxy-anthraquinone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL41525; BDBM50005912; 1,8-Dihydroxy-2-benzyl-9,10-anthraquinone
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| Activity |
IC50 = 56000 nM
|
[8] | |||
| Compound Name |
N-((S)-1-Benzyl-3-chloro-2-oxo-propyl)-3-(3-hydroxy-phenyl)-propionamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL59998; BDBM50085361; N-[(S)-alpha-(Chloroacetyl)phenethyl]-3-hydroxybenzenepropionamide
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| Activity |
IC50 = 58000 nM
|
[9] | |||
| Compound Name |
2-Allyl-1-hydroxy-8-methoxy-anthraquinone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL40861; SCHEMBL16225888; CTK3C8975; DTXSID00441196; BDBM50005893; ZINC13454754; 1-Hydroxy-2-allyl-8-methoxy-9,10-anthraquinone; 2-Allyl-1-hydroxy-8-methoxyanthracene-9,10-dione; 9,10-Anthracenedione, 1-hydroxy-8-methoxy-2-(2-propenyl)-
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| Activity |
IC50 ~ 60000 nM
|
[8] | |||
| Compound Name |
2-Hexyl-1-hydroxy-8-methoxy-anthraquinone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL40805; BDBM50005885; 1-Hydroxy-8-methoxy-2-hexyl-9,10-anthraquinone
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| Activity |
IC50 ~ 60000 nM
|
[8] | |||
| Compound Name |
1-Hydroxy-8-methoxy-2-propyl-anthraquinone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL289034; BDBM50005892; ZINC13454714; 1-Hydroxy-8-methoxy-2-propyl-9,10-anthraquinone
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| Activity |
IC50 ~ 60000 nM
|
[8] | |||
| Compound Name |
1-Hydroxy-2-methylanthraquinone
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Investigative | Compound Info | ||
| Synonyms |
1-hydroxy-2-methyl-9,10-anthraquinone; 1-hydroxy-2-methylanthracene-9,10-dione; Anthraquinone, 1-hydroxy-2-methyl-; CHEMBL42302; 1-Hydroxy-2-methyl-anthraquinone; C15H10O3; CCRIS 6433; NSC37131; 9, 1-hydroxy-2-methyl-; SCHEMBL1426900; CTK2A5513; CTK5B5574; DTXSID80211733; ZINC4783164; BDBM50005901; NSC-37131; AKOS022660290; 1-hydroxy-2-methyl-anthracene-9,10-dione; 1-Hydroxy-2-methylanthra-9,10-quinone #; 9,10-Anthracenedione,1-hydroxy-2-methyl-; 1,10-Anthracenedione, 9-hydroxy-2-methyl-; 9,10-Anthracenedione, 1-hydroxy-2-methyl-; FT-0775767; Q27137873
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| Activity |
IC50 ~ 60000 nM
|
[8] | |||
| Compound Name |
2-Allyl-1,8-dimethoxy-anthraquinone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL41047; CTK3C8974; DTXSID40407514; ZINC5275075; BDBM50005913; AKOS024341752; MCULE-1163939888; 2-allyl-1,8-dimethoxyanthra-9,10-quinone; 2-Allyl-1,8-dimethoxyanthracene-9,10-dione; 1,8-Dimethoxy-2-(2-propenyl)-9,10-anthraquinone; 9,10-Anthracenedione, 1,8-dimethoxy-2-(2-propenyl)-
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| Activity |
IC50 ~ 60000 nM
|
[8] | |||
| Compound Name |
1-Hydroxy-8-methoxy-2-pentyl-anthraquinone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL40281; BDBM50005888; 1-Hydroxy-8-methoxy-2-pentyl-9,10-anthraquinone
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| Activity |
IC50 ~ 60000 nM
|
[8] | |||
| Compound Name |
N-((S)-1-Benzyl-3-chloro-2-oxo-propyl)-3-phenyl-propionamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL64495; BDBM50085349; N-[(S)-alpha-(Chloroacetyl)phenethyl]benzenepropionamide
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| Activity |
IC50 = 63000 nM
|
[9] | |||
| Compound Name |
N-((S)-1-Benzyl-3-chloro-2-oxo-propyl)-3-(4-isopropyl-phenyl)-propionamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL448737; BDBM50085340; N-[(S)-alpha-(Chloroacetyl)phenethyl]-4-isopropylbenzenepropionamide
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| Activity |
IC50 = 65000 nM
|
[9] | |||
| Compound Name |
(3S,6As)-3-Allyl-2-oxo-hexahydro-furo[3,2-b]pyrrole-4-carboxylic acid benzyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL125796; BDBM50066996
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| Activity |
IC50 = 67000 nM
|
[7] | |||
| Compound Name |
3-(4-Chloro-benzenesulfonyl)-1-cyclohexyl-imidazolidine-2,4-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL68431; BDBM50058981
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| Activity |
IC50 = 75000 nM
|
[10] | |||
| Compound Name |
N-((S)-1-Benzyl-3-chloro-2-oxo-propyl)-3-p-tolyl-propionamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL60715; BDBM50085348; N-[(S)-alpha-(Chloroacetyl)phenethyl]-4-methylbenzenepropionamide
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| Activity |
IC50 = 80000 nM
|
[9] | |||
| Compound Name |
(S)-2-[3-(4-Cyano-benzoylamino)-2,2-dimethyl-heptanoylamino]-3-phenyl-propionic acid ethyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL109601; BDBM50073134; N-[2,2-Dimethyl-3-[(4-cyanobenzoyl)amino]heptanoyl]-L-phenylalanine ethyl ester
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| Activity |
IC50 = 83000 nM
|
[11] | |||
| Compound Name |
N-((S)-1-Benzyl-3-chloro-2-oxo-propyl)-3-(4-hydroxy-phenyl)-propionamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL60776; BDBM50085345; N-[(S)-alpha-(Chloroacetyl)phenethyl]-4-hydroxybenzenepropionamide
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| Activity |
IC50 = 91000 nM
|
[9] | |||
| Compound Name |
(3Ar,6S,6aS)-4-methylsulfonyl-6-propan-2-yl-1-[2-(pyrrolidin-1-ylmethyl)-1,3-oxazole-4-carbonyl]-3,3a,6,6a-tetrahydro-2H-pyrrolo[3,2-b]pyrrol-5-one;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL542949; SCHEMBL7479844
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| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
2-(2,3,4,5,6-Pentafluorophenyl)-4,5,6,7-tetrahydro-1,2-benzisothiazol-3(2H)-one 1,1-dioxide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL503392; BDBM50244754
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| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
(3Ar,6S,6aS)-1-[1-(2,2-dimethylpropyl)azetidine-3-carbonyl]-4-methylsulfonyl-6-propan-2-yl-3,3a,6,6a-tetrahydro-2H-pyrrolo[3,2-b]pyrrol-5-one;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL554013; SCHEMBL7352201
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| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
2-(6-Bromopyridin-2-yl)-4,5,6,7-tetrahydro-1,2-benzisothiazol-3(2H)-one 1,1-dioxide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL459683; BDBM50244704
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| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
4,5-Dimethyl-2-(2,3,5,6-tetrafluoropyridin-4-yl)-isothiazol-3(2H)-one 1,1-dioxide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL512758; BDBM50244752
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| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
2-(2,3,5,6-Tetrafluoropyridin-4-yl)-4,5,6,7-tetrahydro-1,2-benzisothiazol-3(2H)-one 1,1-dioxide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL461945; BDBM50244751; 2-(2,3,5,6-Tetrafluoro-4-pyridyl)-4,5,6,7-tetrahydro-1,2-benzoisothiazole-3(2H)-one 1,1-dioxide
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| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
N-{4-[3-(4-Chloro-benzenesulfonyl)-2,4-dioxo-imidazolidin-1-yl]-phenyl}-acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL67334; SCHEMBL7835283; BDBM50059008; N-[4-[3-(4-chlorophenyl)sulfonyl-2,4-dioxoimidazolidin-1-yl]phenyl]acetamide
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| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
(3R,6As)-3-Allyl-2-oxo-hexahydro-furo[3,2-b]pyrrole-4-carboxylic acid benzyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL435213; BDBM50067002
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| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
3-(4-Chloro-benzenesulfonyl)-1-[4-(4-methyl-piperazine-1-carbonyl)-phenyl]-imidazolidine-2,4-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL68162; BDBM50058978
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| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
(4-Carbamimidoylphenyl) 4-[(E)-3-[(2-ethoxy-2-oxoethyl)-prop-2-enylamino]-2-methyl-3-oxoprop-1-enyl]benzoate;methanesulfonic acid
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Investigative | Compound Info | ||
| Synonyms |
ONO 3403; ONO-3403; CHEMBL85136; ONO3403; SCHEMBL1650235
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
4-(4-Guanidinobenzoyloxy)phenylacetic acid
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Investigative | Compound Info | ||
| Synonyms |
Foy 251; 4-GBCE (methanesulfonate); 2-(4-((4-Guanidinobenzoyl)oxy)phenyl)acetic acid methanesulfonic acid salt; CHEMBL433135; Foy-251; {4-[(4-carbamimidamidobenzoyl)oxy]phenyl}acetic acid methanesulfonate(1:1); FOY 251Camostat metabolite; SCHEMBL1649708; SCHEMBL11417275; CTK8D7311; DTXSID20991365; HY-19727A; CS-0016501; FT-0668867
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
2-(6-Chloropyridin-2-yl)-4,5,6,7-tetrahydro-1,2-benzisothiazol-3(2H)-one 1,1-dioxide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL513281; BDBM50244703; 2-(6-Chloro-2-pyridyl)-4,5,6,7-tetrahydro-1,2-benzoisothiazole-3(2H)-one 1,1-dioxide
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| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
1,1-Dioxo-2-pyridin-4-yl-4,5,6,7-tetrahydro-1,2-benzothiazol-3-one;perchloric acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL512569
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| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
1-Phenyl-3-phenylmethanesulfonyl-imidazolidine-2,4-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL69090; BDBM50058986
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| Activity |
IC50 = 100000 nM
|
[10] | |||
| Compound Name |
(3Ar,6S,6aS)-1-[5-[(cyclopropylamino)methyl]pyrazine-2-carbonyl]-4-methylsulfonyl-6-propan-2-yl-3,3a,6,6a-tetrahydro-2H-pyrrolo[3,2-b]pyrrol-5-one;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL543416; SCHEMBL7541127
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| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
4-[3-(4-Chloro-benzenesulfonyl)-2,4-dioxo-imidazolidin-1-yl]-benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL302046; SCHEMBL7825815; BDBM50058991; 1-(4-carboxyphenyl)-3-(4-chlorobenzenesulfonyl)-imidazolidin-2,4-dione; 4-[3-(4-chlorophenyl)sulfonyl-2,4-dioxoimidazolidin-1-yl]benzoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
5-Methyl-4-phenyl-2-(2,3,5,6-tetrafluoropyridin-4-yl)-isothiazol-3(2H)-one 1,1-dioxide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL461946; BDBM50244753
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
2-(Benzothiazole-2-ylthiomethyl)-5-(pivaloyloxy)-4H-pyran-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3093815; BDBM50444297
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-(5-Carboxybenzoxazole-2-ylthiomethyl)-5-(pivaloyloxy)-4H-pyran-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3093814; BDBM50444296
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-[[(E)-3-[4-(4-Carbamimidoylphenoxy)carbonylphenyl]-2-methylprop-2-enoyl]-prop-2-enylamino]acetic acid;methanesulfonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL85154; SCHEMBL5574445
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
3-(4-Chlorophenyl)sulfonyl-1-(3,4-dimethoxyphenyl)imidazolidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL303194; SCHEMBL7825499; BDBM50058970; 3-(4-Chloro-benzenesulfonyl)-1-(3,4-dimethoxy-phenyl)-imidazolidine-2,4-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
3-[3-(4-Chloro-benzenesulfonyl)-2,4-dioxo-imidazolidin-1-yl]-benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL69849; SCHEMBL7825119; BDBM50058988; 3-[3-(4-chlorophenyl)sulfonyl-2,4-dioxoimidazolidin-1-yl]benzoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
3-(3,4-Dimethoxyphenyl)sulfonyl-1-(3,4-dimethylphenyl)imidazolidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL68915; SCHEMBL7838741; BDBM50058990; 3-(3,4-Dimethoxy-benzenesulfonyl)-1-(3,4-dimethyl-phenyl)-imidazolidine-2,4-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
2-(3,5-Difluoropyridin-2-yl)-4,5,6,7-tetrahydro-1,2-benzisothiazol-3(2H)-one 1,1-dioxide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL459684; BDBM50244705
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
Tosylphenylalanyl chloromethyl ketone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
N-Tosyl-L-phenylalanyl chloromethyl ketone; Tos-Phe-CH2Cl; N-Tosyl-L-phenylalanine chloromethyl ketone; N-p-Tosyl-L-phenylalanine chloromethyl ketone; L-1-Tosylamido-2-phenylethyl chloromethyl ketone; l-N-(alpha-(Chloroacetyl)phenethyl)-p-toluenesulfonamide; (S)-N-(4-Chloro-3-oxo-1-phenylbutan-2-yl)-4-methylbenzenesulfonamide; Benzenesulfonamide,N-[(1S)-3-chloro-2-oxo-1-(phenylmethyl)propyl]-4-methyl-; CHEMBL60718; UNII-P598716LJT; MLS000028752; P598716LJT; N-[(2S)-4-chloro-3-oxo-1-phenylbutan-2-yl]-4-methylbenzenesulfonamide; SMR000058518; p-Toluenesulfonamide, N-(alpha-(chloroacetyl)phenethyl)-, (-)-; Benzenesulfonamide, N-(3-chloro-2-oxo-1-(phenylmethyl)propyl)-4-methyl-, (S)-; N-(p-Toluenesulfonyl)-L-phenylalanine chloromethyl ketone; L-1-4'-Tosylamino-2-phenylethyl chloromethyl ketone, 99+%; Benzenesulfonamide, N-[3-chloro-2-oxo-1-(phenylmethyl)propyl]-4-methyl-, (S)-; EINECS 206-954-6; Tosylphenylalanyl chloromethyl ketone, (L)-; BRN 2895215; L-Chloromethyl (2-phenyl-1-(p-toluenesulphonylamino)ethyl) ketone; Opera_ID_1094; Lopac-T-4376; Tosyl-Phe-CMK (TPCK); tosylphenylalanylchloromethane; Lopac0_001157; BSPBio_001541; KBioGR_000261; KBioSS_000261; L-1-p-Tosylamino-2-phenylethyl chloromethyl ketone; MLS001076075; MLS006010721; SCHEMBL927265; cid_439647; Tosyl-L-phenylalanylchloromethane; KBio2_000261; KBio2_002829; KBio2_005397; KBio3_000521; KBio3_000522; KS-00000XQS; BRD5988; DTXSID60883376; Benzenesulfonamide, N-((1S)-3-chloro-2-oxo-1-(phenylmethyl)propyl)-4-methyl-; Bio2_000261; Bio2_000741; HMS1361N03; HMS1791N03; HMS1989N03; HMS3263H15; HMS3402N03; ZINC901254; BRD-5988; Tox21_501157; 7793AH; BDBM50085363; MFCD00000935; NSC727365; PI-122; CCG-205231; LP01157; NSC-727365; SDCCGSBI-0051124.P003; IDI1_034011; NCGC00016020-01; NCGC00094419-01; NCGC00094419-02; NCGC00094419-03; NCGC00094419-04; NCGC00094419-05; NCGC00094419-06; NCGC00094419-07; NCGC00261842-01; AS-35326; p-Tosyl-L-phenylalanine chloromethylketone; EU-0101157; N-P-tosyl-L-phenylalanyl chloromethyl ketone; C02088; K-8605; L-1-Tosylamido-2-phenylethylchloromethyl ketone; T 4376; SR-01000076157; Q7827912; SR-01000076157-1; BRD-K07055988-001-02-4; L-1-TOSYLAMIDE-2-PHENYLETHYL-CHLOROMETHYL KETONE; l-N-(.alpha.-(Chloroacetyl)phenethyl)-p-toluenesulfonamide; (3S)-3-(p-Toluenesulfonyl)amino-1-chloro-4-phenyl-2-butanone; (S)-N-(4-Chloro-3-oxo-1-phenyl-2-butyl)-p-toluenesulfonamide; L-([Toluene-4-sulfonamido]-2-phenyl)ethyl chloromethyl ketone; p-Toluenesulfonamide, N-(.alpha.-(chloroacetyl)phenethyl)-, (-)-; N-[(1S)-1-benzyl-3-chloro-2-oxo-propyl]-4-methyl-benzenesulfonamide; N-p-Tosyl-L-phenylalanine chloromethyl ketone, >=97% (TLC), powder
Click to Show/Hide
|
||||
| Activity |
IC50 = 110000 nM
|
[9] | |||
| Compound Name |
(2S,3S)-N-[(1R)-1-[[3-(Butylamino)-3-oxopropyl]-diphenylsilyl]-3-methylbutyl]-3-methyl-2-[(2-naphthalen-2-ylacetyl)amino]pentanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2182018; BDBM50398079
Click to Show/Hide
|
||||
| Activity |
IC50 = 120000 nM
|
[14] | |||
| Compound Name |
N-((S)-1-Benzyl-3-chloro-2-oxo-propyl)-3-(4-fluoro-phenyl)-propionamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL60241; BDBM50085359; N-[(S)-alpha-(Chloroacetyl)phenethyl]-4-fluorobenzenepropionamide
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||||
| Activity |
IC50 = 130000 nM
|
[9] | |||
| Compound Name |
1-Oxo-2-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-methyl]-2,9-dihydro-1H-beta-carboline-8-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL174215; BDBM50036060
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|
||||
| Activity |
Ki = 130000 nM
|
[15] | |||
| Compound Name |
6-(((5-(Cyclopropanecarboxamido)-1,3,4-thiadiazol-2-yl)thio)methyl)-4-oxo-4H-pyran-3-yl 3-fluorobenzoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3093805; BDBM50444298; ZINC11025900; AKOS024657172; MCULE-3931999485; SR-01000021298; SR-01000021298-1; F2532-0362
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 134000 nM
|
[16] | |||
| Compound Name |
2-[(5-Amino-4H-1,2,4-triazol-3-yl)sulfanyl]-N-(3,5-dichlorophenyl)-2-phenylacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3219672; AKOS033611139; MCULE-4764172078; Z18355736
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 139000 nM
|
[16] | |||
| Compound Name |
N-((S)-1-Benzyl-3-chloro-2-oxo-propyl)-3-(3,4-dimethoxy-phenyl)-propionamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL60245; BDBM50085350; N-[(S)-alpha-(Chloroacetyl)phenethyl]-3,4-dimethoxybenzenepropionamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 140000 nM
|
[9] | |||
| Compound Name |
6-(3,5-Difluoroanilino)-9-(2,2-difluoroethyl)purine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
compound 33 [PMID: 19908842]; CHEMBL578159; MLS002471784; GTPL8874; SCHEMBL3346407; HMS2213P07; HMS3348G08; BDBM50303436; NCGC00182115-01; NCGC00182115-02; SMR001395198; Q27076570; 9-(2,2-difluoroethyl)-6-(3,5-difluorophenylamino)-9H-purine-2-carbonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 = 147910.84 nM
|
[17] | |||
| Compound Name |
N-[(2S)-6-Amino-1-[5-[[4-[2-(3,4-dichlorophenyl)ethoxy]phenyl]methyl]-1,2,4-oxadiazol-3-yl]-1-oxohexan-2-yl]-3,4-difluorobenzamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL536972
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|
||||
| Activity |
Ki ~ 150000 nM
|
[18] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 13 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Acetyl-Ala-Ala-Pro-Ala-trifluromethane
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL130128; Acetyl-Ala-Ala-Pro-Ala-trifluromethane; BDBM50014742
Click to Show/Hide
|
||||
| Activity |
Ki > 800000 nM
|
[19] | |||
| Compound Name |
N-((S)-1-Benzyl-3-chloro-2-oxo-propyl)-3-(3-methoxy-phenyl)-propionamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL59988; BDBM50085347; N-[(S)-alpha-(Chloroacetyl)phenethyl]-3-methoxybenzenepropionamide
Click to Show/Hide
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||||
| Activity |
IC50 = 210000 nM
|
[9] | |||
| Compound Name |
4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
AEBSF HCl; AEBSF hydrochloride; AEBSF; Pefabloc SC; AEBSF (hydrochloride); AEBSF, Hydrochloride; MFCD00132962; 4-(2-Aminoethyl)benzene-1-sulfonyl fluoride hydrochloride; 4-(2-Aminoethyl)benzenesulphonyl fluoride hydrochloride; Benzenesulfonyl fluoride, 4-(2-aminoethyl)-, hydrochloride; AEBSF.HCl; 4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride; 30827-99-7 (HCl); Benzenesulfonyl fluoride, 4-(2-aminoethyl)-, hydrochloride (1:1); AEBSF hydrochloride, 98%; 4-(2-aminoethyl)benzenesulfonyl fluoride;hydrochloride; 4-(2-aminoethyl) benzenesulfonyl fluoride hydrochloride; Benzenesulfonylfluoride, 4-(2-aminoethyl)-, hydrochloride (1:1); CHEMBL1256178; SR-01000075690; AEBSF-hydrochloride; PubChem14462; EU-0100132; ACMC-1CTY2; 4-(2-Aminoethyl)benzenesulfonylfluoride, HCl; SCHEMBL25973; MLS002153464; AEBSF HCl Biochemistry grade; CTK1C4244; KS-00000VYT; DTXSID60184830; BCP32155; EX-A2487; Tox21_500132; ANW-43152; NSC727364; PC5642; Pefabloc(R) SC, analytical standard; s7378; SBB003219; AKOS015847774; CCG-207883; FS-5456; LP00132; NSC-727364; VZ27664; NCGC00093623-01; NCGC00260817-01; AK-82709; HY-12821; QC-10428; SMR001230821; SY007034; 4-(2-Aminoethyl)benzenesulfonylfluoride HCl; AB0014776; DB-047913; 2-AMINOETHYLPHENYLSULFONEHYDROCHLORIDE; FT-0616512; SW219355-1; 4-(2-Aminoethyl)Benzenesulfonyl Fluoride HCl; AEBSF Ready Made Solution, 100 mM in water; 4-(2-Aminoethyl)benzenesulfonyl fluoride, HCl; A 8456; A14270; K-7365; M01245; P-1195; [4-(2-aminoethyl)phenyl]fluorosulfone, chloride; Pefabloc, Antibiotic for Culture Media Use Only; 827A997; 4-(2-Aminoethyl)benzenesulfonylfluoridehydrochloride; SR-01000075690-1; 4-(2-aminoethyl)-benzenesulfonylfluoride hydrochloride; 4-(2-aminoethyl)benzenesulfonyl fluoride,hydrochloride; Benzenesulfonyl fluoride, p-(2-aminoethyl)-, hydrochloride; Pefabloc(R) SC, certified reference material, TraceCERT(R); 4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride, >=97%
Click to Show/Hide
|
||||
| Activity |
IC50 = 250000 nM
|
[14] | |||
| Compound Name |
5,5-Dimethyl-3-(4-methylphenyl)sulfonyl-1,3-oxazolidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2029557; BDBM50384112
Click to Show/Hide
|
||||
| Activity |
IC50 = 369000 nM
|
[20] | |||
| Compound Name |
Methyl 2-(3-benzamido-3-benzyl-2-oxoazetidin-1-yl)acetate
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL175648; BDBM50403613
Click to Show/Hide
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||||
| Activity |
Ki = 400000 nM
|
[21] | |||
| Compound Name |
2,2',4-Trihydroxybenzophenone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
1,1,3-Trihydroxybenzophenone; CHEMBL470701; (2,4-dihydroxyphenyl)-(2-hydroxyphenyl)methanone; Methanone, (2,4-dihydroxyphenyl)(2-hydroxyphenyl)-; Benzophenone, 2,2',4-trihydroxy-; SCHEMBL93207; 2,2'',4-trihydroxybenzophenone; CTK0F5619; DTXSID70342106; ZINC136125; BDBM50249353; AKOS022657180; MCULE-9477407393; ST029236; 2,4-dihydroxyphenyl 2-hydroxyphenyl ketone; (2,4-Dihydroxyphenyl)(2-hydroxyphenyl)methanone #
Click to Show/Hide
|
||||
| Activity |
IC50 = 433200 nM
|
[22] | |||
| Compound Name |
(S)-2-[3-(4-Cyano-benzoylamino)-2,2-dimethyl-decanoylamino]-3-phenyl-propionic acid ethyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL111166; BDBM50073124; N-[2,2-Dimethyl-3-[(4-cyanobenzoyl)amino]decanoyl]-L-phenylalanine ethyl ester
Click to Show/Hide
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||||
| Activity |
IC50 = 440000 nM
|
[11] | |||
| Compound Name |
(S)-1-(((5-(Dimethylamino)naphthalen-1-yl)sulfonyl)-L-alanyl-L-alanyl)-N-((S)-1,1,1-trifluoro-4-methyl-2-oxopentan-3-yl)pyrrolidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL339870; Mdl 27324; BDBM50014732; Dns-L-Ala-L-Ala-L-Pro-L-Val-Trifluoromethane
Click to Show/Hide
|
||||
| Activity |
Ki > 600000 nM
|
[19] | |||
| Compound Name |
N-((S)-1-Benzyl-3-chloro-2-oxo-propyl)-3-(3-fluoro-phenyl)-propionamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL305319; BDBM50085365; N-[(S)-alpha-(Chloroacetyl)phenethyl]-3-fluorobenzenepropionamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 890000 nM
|
[9] | |||
| Compound Name |
6-Chlorooxindole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
6-chloroindolin-2-one; 6-Chloro-1,3-dihydro-2H-indol-2-one; 6-Chloro-2-oxindole; 6-chloro-1,3-dihydroindol-2-one; 6-Chloro-2-indolinone; 6-Chloro 2-oxindole; 2H-Indol-2-one, 6-chloro-1,3-dihydro-; 6-chloroindole-2(3h)-one; MFCD00209962; 6-chloro-2,3-dihydro-1H-indol-2-one; 6-chloro-1,3-dihydro-indol-2-one; CHEMBL1232568; 6-Chlorooxindole, 98%; 6-chloro-oxindol; 6-chloro oxindole; 6-chloro-oxindole; zlchem 927; PubChem1674; 6-chloro-2-oxo-indole; 6-ctiloro-2-oxo-indole; 6-chloroindol-2(3h)-one; ACMC-1B12V; KSC492O1P; SCHEMBL221280; 6-Chloro-2-oxindole, 97%; IND066; CENVPIZOTHULGJ-UHFFFAOYSA-; CTK3J2717; DTXSID00353003; ZLD0393; ZINC157269; ACT06122; ALBB-021329; STR08222; ANW-32484; BBL009871; BDBM50434122; CC0122; SBB058442; STK709735; 6-Chloro-1,3,-dihydro-indol-2-one; AKOS000119599; AB04797; AC-2683; CS-W008657; MCULE-4425259060; KS-000004Z5; 6-chloro-1,3-dihydro-2h-indole-2-one; 6-chloroindole-1,3-dihydro(2h)-2-one; 6-chloro- 1,3-dihydro-2H-indol-2-one; AC-22698; AK-29404; BR-29404; SC-05371; SY002545; AB0008330; FT-0640375; ST50407077; EN300-17337; M-2864; 341C378; 5W-0082; Q27460049; F0001-1479
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[23] | |||
| Compound Name |
N-((S)-1-Benzyl-3-chloro-2-oxo-propyl)-3-(2-fluoro-phenyl)-propionamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL62160; BDBM50085351; N-[(S)-alpha-(Chloroacetyl)phenethyl]-2-fluorobenzenepropionamide
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[9] | |||
| Compound Name |
4-N-[(2S)-3-Methyl-1-oxo-1-[(2S)-2-[(5,5,6,6,6-pentafluoro-2-methyl-4-oxohexan-3-yl)carbamoyl]pyrrolidin-1-yl]butan-2-yl]-1-N-(4,4,4-trifluoro-3-oxo-1-phenylbutan-2-yl)benzene-1,4-dicarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL150384; BDBM50281590
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[24] | |||
| Compound Name |
2-{(S)-2-[((S)-1-{(S)-2-[4-(4-Chloro-benzenesulfonylaminocarbonyl)-benzoylamino]-3-methyl-butyryl}-pyrrolidine-2-carbonyl)-amino]-3-methyl-butyryl}-benzooxazole-5-carboxylic acid amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL419985; BDBM50031187
Click to Show/Hide
|
||||
| Activity |
Ki > 2000000 nM
|
[25] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Optimization of O3-acyl kojic acid derivatives as potent and selective human neutrophil elastase inhibitors. J Med Chem. 2013 Dec 12;56(23):9802-6. | ||||
| REF 2 | Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity. J Med Chem. 2008 Jul 24;51(14):4150-69. | ||||
| REF 3 | New orally active serine protease inhibitors. J Med Chem. 1995 Jul 7;38(14):2521-3. | ||||
| REF 4 | Stable and Long-Lasting, Novel Bicyclic Peptide Plasma Kallikrein Inhibitors for the Treatment of Diabetic Macular Edema. J Med Chem. 2018 Apr 12;61(7):2823-2836. | ||||
| REF 5 | Inhibition of the activation of multiple serine proteases with a cathepsin C inhibitor requires sustained exposure to prevent pro-enzyme processing. J Biol Chem. 2007 Jul 20;282(29):20836-46. | ||||
| REF 6 | Design and synthesis of dipeptidyl nitriles as potent, selective, and reversible inhibitors of cathepsin C. Bioorg Med Chem Lett. 2009 Sep 15;19(18):5392-6. | ||||
| REF 7 | Syntheses of trans-5-oxo-hexahydro-pyrrolo[3,2-b]pyrroles and trans-5-oxo-hexahydro-furo[3,2-b]pyrroles (pyrrolidine trans-lactams and trans-lactones): new pharmacophores for elastase inhibition. J Med Chem. 1998 Oct 8;41(21):3919-22. | ||||
| REF 8 | Novel anthraquinone inhibitors of human leukocyte elastase and cathepsin G. J Med Chem. 1992 May 1;35(9):1597-605. | ||||
| REF 9 | Structure-activity relationship studies of chloromethyl ketone derivatives for selective human chymase inhibitors. Bioorg Med Chem Lett. 2000 Feb 7;10(3):199-201. | ||||
| REF 10 | Substituted 3-(phenylsulfonyl)-1-phenylimidazolidine-2,4-dione derivatives as novel nonpeptide inhibitors of human heart chymase. J Med Chem. 1997 Jul 4;40(14):2156-63. | ||||
| REF 11 | N-[2,2-dimethyl-3-(N-(4-cyanobenzoyl)amino)nonanoyl]-L-phenylalanine ethyl ester as a stable ester-type inhibitor of chymotrypsin-like serine proteases: structural requirements for potent inhibition of alpha-chymotrypsin. J Med Chem. 1999 Jan 28;42(2):312-23. | ||||
| REF 12 | Discovery of further pyrrolidine trans-lactams as inhibitors of human neutrophil elastase (HNE) with potential as development candidates and the crystal structure of HNE complexed with an inhibitor (GW475151). J Med Chem. 2002 Aug 29;45(18):3878-90. | ||||
| REF 13 | Synthesis and elastase-inhibiting activity of 2-pyridinyl-isothiazol-3(2H)-one 1,1-dioxides. Bioorg Med Chem. 2008 Sep 1;16(17):8127-35. | ||||
| REF 14 | Synthesis and evaluation of silanediols as highly selective uncompetitive inhibitors of human neutrophil elastase. J Med Chem. 2012 Sep 13;55(17):7900-8. | ||||
| REF 15 | Non-peptidic inhibitors of human leukocyte elastase. 4. Design, synthesis, and in vitro and in vivo activity of a series of beta-carbolinone-containing trifluoromethyl ketones. J Med Chem. 1995 Jan 6;38(1):86-97. | ||||
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