Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T86582 | Target Info | |||
| Target Name | Excitatory amino acid transporter 1 (SLC1A3) | ||||
| Synonyms |
Solute carrier family 1 member 3; Sodium-dependent glutamate/aspartate transporter 1; GLAST-1; EAAT1
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|
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| Target Type | Literature-reported Target | ||||
| Gene Name | SLC1A3 | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 24 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
L-beta-BA
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|
Investigative | Compound Info | ||
| Synonyms |
L-beta-threo-benzyl-aspartate
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|
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| Activity |
IC50 = 51000 nM
|
[1] | |||
| Compound Name |
(2S,4R)-4-Butylglutamic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL381004; BDBM50178685; ZINC13677532
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|
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| Activity |
Ki = 50000 nM
|
[2] | |||
| Compound Name |
(2S,4R)-4-Isobutylglutamic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL199617; BDBM50178687; ZINC13677538
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|
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| Activity |
Ki = 55000 nM
|
[2] | |||
| Compound Name |
(2S)-2-Amino-3-[(3,5-dimethylphenyl)sulfonylamino]butanedioic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3919821; BDBM50197043
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|
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| Activity |
IC50 = 63000 nM
|
[1] | |||
| Compound Name |
(2S)-2-Amino-4-[4-methyl-3-[3-(trifluoromethyl)phenyl]anilino]-4-oxobutanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2113114; BDBM50410446
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|
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| Activity |
IC50 = 63000 nM
|
[3] | |||
| Compound Name |
(2S)-2-Amino-3-(naphthalen-1-ylsulfonylamino)butanedioic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3967211; BDBM50197033
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|
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| Activity |
IC50 = 64565.42 nM
|
[1] | |||
| Compound Name |
(3S)-3-Methoxyaspartic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL78678; CHEMBL1790044; BDBM50093752; (2S, 3S)-3-Amino-2-methoxy-pentanedioic acid
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|
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| Activity |
IC50 = 69000 nM
|
[4] | |||
| Compound Name |
(2S)-2-Amino-3-(phenoxycarbonylamino)butanedioic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3896313; BDBM50197037
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|
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| Activity |
IC50 = 70000 nM
|
[1] | |||
| Compound Name |
Chembl4161764
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50366649
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|
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| Activity |
IC50 = 87000 nM
|
[5] | |||
| Compound Name |
Chembl4168620
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50366654
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|
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| Activity |
IC50 = 99000 nM
|
[5] | |||
| Compound Name |
L-Serine O-sulfate
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|
Investigative | Compound Info | ||
| Synonyms |
Serine O-sulfate; O-Sulfo-L-Serine; H-SER(SO3H)-OH; sulfoserine; O-sulfonato-L-serine; L-Serine, O-sulfo-; UNII-81K4VO7FNP; 81K4VO7FNP; (S)-2-Amino-3-(sulfooxy)propanoic acid; L-serine O-(hydrogen sulfate); (2S)-2-amino-3-(sulfooxy)propanoic acid; C3H7NO6S; l-serine-o-sulfate; (2S)-2-amino-3-sulfooxypropanoic acid; L-SOS; CHEMBL28885; SCHEMBL4314030; BDBM17663; CTK2F6092; DTXSID80211652; ZINC4095907; L-Serine, hydrogen sulfate (ester); 7239AH; KM0646; MFCD00672378; AKOS006271404; DB03497; AS-46936; C02703; Q27098248; UNII-63CV1GEK3Y component LFZGUGJDVUUGLK-REOHCLBHSA-N
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|
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| Activity |
IC50 = 100000 nM
|
[6] | |||
| Compound Name |
(2S)-2-Amino-3-[(2,6-dichlorophenyl)sulfonylamino]butanedioic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3946565; BDBM50197042
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|
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| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
(2S,4R)-2-Amino-4-[2-(phenylmethoxycarbonylamino)ethyl]pentanedioic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312681; BDBM50426291
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|
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| Activity |
IC50 = 100000 nM
|
[7] | |||
| Compound Name |
(RS)-2-amino-3-(1-hydroxy-1,2,3-triazol-5-yl)propionate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL321164; BDBM50107950; 3-Hydroxy-alpha-amino-3H-1,2,3-triazole-4-propionic acid; 2-Amino-3-(3-hydroxy-3H-[1,2,3]triazol-4-yl)-propionic acid
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|
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| Activity |
IC50 = 100000 nM
|
[6] | |||
| Compound Name |
5-Oxo-4,7-Diphenyl-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1259065; BDBM50328517
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|
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| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
(2S)-2-Amino-3-[[3-(trifluoromethyl)phenyl]sulfonylamino]butanedioic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3894651; BDBM50197040
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|
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| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
N-(3-Cyano-5-oxo-4,7-diphenyl-4,6,7,8-tetrahydrochromen-2-yl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1259064; BDBM50328516; N-(3-Cyano-5-oxo-4,7-diphenyl-5,6,7,8-tetrahydro-4H-chromen-2-yl)acetamide
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|
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| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
(2S)-2-Amino-4-(4-naphthalen-2-ylanilino)-4-oxobutanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2113128; BDBM50410453
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|
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| Activity |
IC50 = 100000 nM
|
[3] | |||
| Compound Name |
(2S,4R)-4-Pentylglutamic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL58027; 2-Amino-4-pentyl-pentanedioic acid; BDBM50088220; ZINC13677534
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|
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| Activity |
Ki = 117489.76 nM
|
[2] | |||
| Compound Name |
(1R,4S,5R,6S)-3-Azabicyclo[3.3.0]octane-4,6-dicarboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL371301; Azabicyclo-ODD; BDBM50180145
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|
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| Activity |
Ki = 127000 nM
|
[9] | |||
| Compound Name |
(2S,3R)-2-Amino-3-(benzenesulfonamido)butanedioic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3911432; BDBM50197036
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|
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| Activity |
IC50 = 199526.23 nM
|
[1] | |||
| Compound Name |
(2S,4R)-2-Amino-4-(2-cyanoethyl)pentanedioic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312682; BDBM50426290
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|
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| Activity |
IC50 = 200000 nM
|
[7] | |||
| Compound Name |
(1R,2S)-2-[(S)-Amino(carboxy)methyl]-2-methylcyclobutane-1-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2373300
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|
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| Activity |
Ki = 200000 nM
|
[10] | |||
| Compound Name |
(1s,2r)-2-[(S)-Amino(Carboxy)methyl]cyclobutanecarboxylic Acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL384474; Cyclobutaneacetic acid, alpha-amino-2-carboxy-, (alphaS,1R,2S)-; BDBM50197103; (2S,1'R,2'S)-2-(2'-Carboxycyclobutyl)glycine; (2S,1''R,2''S)-2-(2''-Carboxycyclobutyl)glycine; Q27460598
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|
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| Activity |
Ki = 200000 nM
|
[10] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 51 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
TAN-950A
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|
Terminated | Compound Info | ||
| Synonyms |
CHEMBL317234; 2-amino-3-(3-oxo-1,2-oxazol-4-yl)propanoic acid; 3-(3-hydroxy-1,2-oxazol-4-yl)alanine; AC1Q6BSY; AC1L2ZPH; AC1Q50A9; SCHEMBL5678957; BDBM50107954; AKOS030549352; 3-Hydroxy-alpha-aminoisoxazole-4-propionic acid; 2-Amino-3-(3-hydroxy-isoxazol-4-yl)-propionic acid; 4-Isoxazolepropanoic acid, alpha-amino-2,3-dihydro-3-oxo-
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|
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| Activity |
IC50 = 270000 nM
|
[11] | |||
| Compound Name |
HINOKININ
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|
Investigative | Compound Info | ||
| Synonyms |
Hinokinin; (-)-Hinokinin; 26543-89-5; CHEBI:5722; CHEMBL242011; (3R,4R)-3,4-Bis(benzo[d][1,3]dioxol-5-ylmethyl)dihydrofuran-2(3H)-one; (3R,4R)-3,4-bis(1,3-benzodioxol-5-ylmethyl)dihydrofuran-2(3H)-one; (3R-trans)-3,4-bis(1,3-benzodioxol-5-ylmethyl)dihydrofuran-2(3H)-one; hinoquinin; (-)-hinoquinin; AC1L9DKH; Epitope ID:116880; SCHEMBL1121862; MolPort-039-338-821; ZINC1872258; BDBM50218812; AKOS027324070; LS-190466; C10627; (2r,3r)-2,3-di-(3,4-methylenedioxybenzyl)-butyrolactone
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|
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| Activity |
IC50 > 500000 nM
|
[12] | |||
| Compound Name |
(2S,4R)-4-(3-Methoxy-3-oxopropyl)glutamic Acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL482080; (2s,4r)-4-(3-Methoxy-3-Oxopropyl) Glutamic Acid; (2S,4R)-4-(3-Methoxy-3-oxopropyl)glutamic Acid; ZINC40934342; BDBM50252048; (4R)-4-(3-methoxy-3-oxopropyl)-L-glutamic acid; (2S,4R)-2-amino-4-(3-methoxy-3-oxopropyl)pentanedioic acid
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|
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| Activity |
IC50 = 1000000 nM
|
[13] | |||
| Compound Name |
(2S,4R)-4-(3-Hydroxy-3-oxopropyl)glutamic Acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL482081; BDBM50252049; ZINC40934632; (1S,3R)-1-aminopentane-1,3,5-tricarboxylic acid
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|
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| Activity |
IC50 > 300000 nM
|
[14] | |||
| Compound Name |
(2S,4R)-2-Amino-4-[3-oxo-3-(prop-2-ynylamino)propyl]pentanedioic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312396; BDBM50426296
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|
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| Activity |
IC50 > 300000 nM
|
[7] | |||
| Compound Name |
(2S,4R)-2-Amino-4-(3-oxo-3-piperidin-1-ylpropyl)pentanedioic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312400; BDBM50426293
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|
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| Activity |
IC50 > 300000 nM
|
[7] | |||
| Compound Name |
(2S)-2-Amino-3-[(4-tert-butylphenyl)sulfonylamino]butanedioic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3903821; BDBM50197055
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|
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| Activity |
IC50 = 300000 nM
|
[1] | |||
| Compound Name |
(2S,4R)-2-Amino-4-[3-(diethylamino)-3-oxopropyl]pentanedioic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312399; BDBM50426294
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|
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| Activity |
IC50 > 300000 nM
|
[7] | |||
| Compound Name |
(2S)-2-Amino-3-[(4-methylsulfonylphenyl)sulfonylamino]butanedioic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3979993; BDBM50197056
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|
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| Activity |
IC50 = 300000 nM
|
[1] | |||
| Compound Name |
(2S)-2-Amino-3-[(2,3,4,5,6-pentafluorophenyl)sulfonylamino]butanedioic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3955070; BDBM50197047
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|
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| Activity |
IC50 > 300000 nM
|
[1] | |||
| Compound Name |
2-Amino-5-oxo-4,7-diphenyl-7,8-dihydro-4H-pyrano[3,2-c]pyran-3-carbonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2062779
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|
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| Activity |
IC50 > 300000 nM
|
[15] | |||
| Compound Name |
(1R)-1-[(S)-2-Amino-3-oxo-3-hydroxypropyl]cyclopropane-1alpha,2alpha-dicarboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3786667; BDBM50159148; J3.605.576F
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|
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| Activity |
IC50 > 300000 nM
|
[14] | |||
| Compound Name |
(1S)-1-[(S)-2-Amino-3-oxo-3-hydroxypropyl]cyclopropane-1beta,2beta-dicarboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3786026; BDBM50159147; J3.605.575H
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|
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| Activity |
IC50 > 300000 nM
|
[14] | |||
| Compound Name |
(2S,4R)-Azepane-2,4-dicarboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312686; BDBM50426286; ZINC95593971
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|
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| Activity |
IC50 > 300000 nM
|
[7] | |||
| Compound Name |
(1R)-1-[(S)-2-Amino-3-oxo-3-hydroxypropyl]cyclopropane-1alpha,2beta-dicarboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3787264; BDBM50159150; J3.605.574J
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|
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| Activity |
IC50 > 300000 nM
|
[14] | |||
| Compound Name |
(2S)-2-Amino-3-benzamidobutanedioic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3913275; BDBM50196925
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|
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| Activity |
IC50 = 300000 nM
|
[1] | |||
| Compound Name |
(2S)-2-Amino-3-[(3-carboxyphenyl)sulfonylamino]butanedioic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3947455; BDBM50197045
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|
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| Activity |
IC50 > 300000 nM
|
[1] | |||
| Compound Name |
(2S)-2-Amino-3-[benzenesulfonyl(methyl)amino]butanedioic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3964129; BDBM50197052
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|
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| Activity |
IC50 > 300000 nM
|
[1] | |||
| Compound Name |
2-Amino-5-oxo-4,7-diphenyl-4,6,7,8-tetrahydropyrano[3,2-c]pyridine-3-carbonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2062778
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|
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| Activity |
IC50 > 300000 nM
|
[15] | |||
| Compound Name |
(1S,2R)-1-[(2S)-2-Amino-2-carboxyethyl]cyclopropane-1,2-dicarboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3786938; BDBM50159146
Click to Show/Hide
|
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| Activity |
IC50 > 300000 nM
|
[14] | |||
| Compound Name |
(2S,4R)-2-Amino-4-(3-anilino-3-oxopropyl)pentanedioic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312397; BDBM50426295
Click to Show/Hide
|
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| Activity |
IC50 > 300000 nM
|
[7] | |||
| Compound Name |
(3S,5S)-2-Aza-bicyclo[2.2.1]heptane-3,5-dicarboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL199331; BDBM50180146
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|
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| Activity |
Ki > 400000 nM
|
[9] | |||
| Compound Name |
(2S,4S)-4-(Benzyloxymethyl)glutamic Acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL446256; BDBM50252046; ZINC40833931; (2S,4S)-2-amino-4-(benzyloxymethyl)pentanedioic acid
Click to Show/Hide
|
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| Activity |
Ki = 450000 nM
|
[13] | |||
| Compound Name |
(2S,4R)-2-Amino-4-[3-oxo-3-(phenylmethoxyamino)propyl]pentanedioic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312402; BDBM50426292
Click to Show/Hide
|
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| Activity |
IC50 > 1000000 nM
|
[7] | |||
| Compound Name |
2-Amino-3-(3-hydroxy-3H-imidazol-4-yl)-propionic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL102612; 3-l-histidinol; SCHEMBL743804; BDBM50107946; 3-Hydroxy-alpha-amino-3H-imidazole-4-propionic acid
Click to Show/Hide
|
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| Activity |
IC50 > 1000000 nM
|
[11] | |||
| Compound Name |
(2S,4R)-2-Amino-4-(2-aminoethyl)pentanedioic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312684; BDBM50426288
Click to Show/Hide
|
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| Activity |
IC50 > 1000000 nM
|
[7] | |||
| Compound Name |
Ethyl (1E)-N-(3-cyano-5-oxo-4,7-diphenyl-4,6,7,8-tetrahydrochromen-2-yl)methanimidate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1259045; BDBM50328515; (E)-Ethyl N-3-Cyano-5-oxo-4,7-diphenyl-5,6,7,8-tetrahydro-4H-chromen-2-ylformimidate
Click to Show/Hide
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| Activity |
IC50 > 1000000 nM
|
[8] | |||
| Compound Name |
(2S,4R)-4-(2-Carboxyphenoxy)pyrrolidine-2-carboxylic acid;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4089715; BDBM50234094
Click to Show/Hide
|
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| Activity |
IC50 > 1000000 nM
|
[16] | |||
| Compound Name |
2-Amino-3-(1-hydroxy-1H-imidazol-2-yl)-propionic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL104197; BDBM50107955; 1-Hydroxy-alpha-amino-1H-imidazole-2-propionic acid
Click to Show/Hide
|
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| Activity |
IC50 > 1000000 nM
|
[11] | |||
| Compound Name |
5-Methyl-1-hydroxy-alpha-amino-1H-imidazole-2-propionic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL104039; BDBM50107947; 2-Amino-3-(1-hydroxy-5-methyl-1H-imidazol-2-yl)-propionic acid
Click to Show/Hide
|
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| Activity |
IC50 > 1000000 nM
|
[11] | |||
| Compound Name |
(2S,4R)-2-Amino-4-(3-aminopropyl)pentanedioic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312685; BDBM50426287
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|
||||
| Activity |
IC50 > 1000000 nM
|
[7] | |||
| Compound Name |
(2S)-2-Amino-3-(4-phenyltriazol-1-yl)butanedioic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3921460; BDBM50197051
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[1] | |||
| Compound Name |
(4r)-4-[3-(Methylamino)-3-Oxopropyl]-L-Glutamic Acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL500042; BDBM50252051; ZINC40974521; (2S,4R)-4-(3-Methylamino-3-oxopropyl)glutamic acid; Q27453181; (2S,4R)-2-amino-4-(3-(methylamino)-3-oxopropyl)pentanedioic acid
Click to Show/Hide
|
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| Activity |
IC50 > 1000000 nM
|
[13] | |||
| Compound Name |
2-Amino-3-(2-hydroxy-2H-pyrazol-3-yl)-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL320290; BDBM50107948; 2-Hydroxy-alpha-amino-2H-pyrazole-3-propionic acid
Click to Show/Hide
|
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| Activity |
IC50 > 1000000 nM
|
[11] | |||
| Compound Name |
5-Methyl-3-hydroxy-alpha-amino-3H-1,2,3-triazole-4-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL104208; BDBM50107949; 2-Amino-3-(3-hydroxy-5-methyl-3H-[1,2,3]triazol-4-yl)-propionic acid
Click to Show/Hide
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||||
| Activity |
IC50 > 1000000 nM
|
[11] | |||
| Compound Name |
(2S,4R)-2-Amino-4-[3-(hydroxyamino)-3-oxopropyl]pentanedioic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312683; BDBM50426289
Click to Show/Hide
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||||
| Activity |
IC50 > 1000000 nM
|
[7] | |||
| Compound Name |
(2S,4R)-4-(4-Carboxyphenoxy)pyrrolidine-2-carboxylic acid;hydrochloride
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4100460; BDBM50234095
Click to Show/Hide
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||||
| Activity |
IC50 > 1000000 nM
|
[16] | |||
| Compound Name |
(2S,4R)-4-(3-Carboxyphenoxy)pyrrolidine-2-carboxylic acid;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4073637; BDBM50234092
Click to Show/Hide
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||||
| Activity |
IC50 > 1000000 nM
|
[16] | |||
| Compound Name |
(2S,4R)-4-(2,2-Diphenylethylamino-3-oxopropyl)glutamic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL480169; BDBM50251894
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||||
| Activity |
Ki = 1000000 nM
|
[13] | |||
| Compound Name |
2-Methyl-3-hydroxy-alpha-amino-3H-imidazole-4-propionic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL104065; BDBM50107952; 2-Amino-3-(3-hydroxy-2-methyl-3H-imidazol-4-yl)-propionic acid
Click to Show/Hide
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||||
| Activity |
IC50 > 1000000 nM
|
[11] | |||
| Compound Name |
4-Methyl-2-hydroxy-alpha-amino-2H-pyrazole-3-propionic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL107160; BDBM50107951; 2-Amino-3-(2-hydroxy-4-methyl-2H-pyrazol-3-yl)-propionic acid
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[11] | |||
| Compound Name |
5-Methyl-3-hydroxy-alpha-amino-3H-imidazole-4-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL323289; BDBM50107953; 2-Amino-3-(3-hydroxy-5-methyl-3H-imidazol-4-yl)-propionic acid
Click to Show/Hide
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||||
| Activity |
IC50 > 1000000 nM
|
[11] | |||
| Compound Name |
(2S,4R)-4-(3-Benzylamino-3-oxopropyl)glutamic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL518313; BDBM50251893; (2S,4R)-2-amino-4-(3-(benzylamino)-3-oxopropyl)pentanedioic acid
Click to Show/Hide
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||||
| Activity |
Ki = 1000000 nM
|
[13] | |||
| Compound Name |
(2S,4S)-4-(2-Carboxyphenoxy)pyrrolidine-2-carboxylic acid;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4102927; BDBM50234097
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[16] | |||
| Compound Name |
Dihydrokainic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Dihydrokainate; (2S,3S,4R)-2-Carboxy-4-isopropyl-3-pyrrolidineacetic acid; CHEMBL279561; (2S,3S,4R)-2-carboxy-4-(1-methylethyl)-3-pyrrolidineacetic acid; (3S,4R)-3-(carboxymethyl)-4-(propan-2-yl)-L-proline; (2S,3S,4R)-3-(carboxymethyl)-4-(propan-2-yl)pyrrolidine-2-carboxylic acid; (2S,3S,4R)-3-(carboxymethyl)-4-isopropylpyrrolidine-2-carboxylic acid; Dihydrokainic Acid, Natural; Dihydrokaioic Acid; SCHEMBL155919; CTK1H2670; DTXSID20200489; HMS3261K11; ZINC3995564; Tox21_500375; BDBM50240399; PDSP2_001490; AKOS024456387; CCG-221679; LP00375; SDCCGSBI-0633704.P001; VZ31869; NCGC00261060-01; B6208; Dihydrokainic acid, >=98% (HPLC), powder; A829114; SR-01000597697; SR-01000597697-1; (2R,3R,4S)-3-(carboxymethyl)-4-isopropylpyrrolidinium-2-carboxylate; (2S,3S,4R)-3-(carboxymethyl)-4-propan-2-yl-2-pyrrolidinecarboxylic acid; (2S,3S,4R)-4-isopropyl-3-(2-oxido-2-oxoethyl)pyrrolidinium-2-carboxylate; 3-Pyrrolidineacetic acid, 2-carboxy-4-(1-methylethyl)-, (2S,3S,4R)-; 3-Pyrrolidineaceticacid, 2-carboxy-4-(1-methylethyl)-, (2S,3S,4R)-; (2S,3S,4R)-3-(2-hydroxy-2-oxoethyl)-4-propan-2-yl-pyrrolidine-2-carboxylic acid; (2S-(2alpha,3beta,4beta))-2-Carboxy-4-(1-methylethyl)-3-pyrrolidineacetic acid
Click to Show/Hide
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||||
| Activity |
IC50 > 3000000 nM
|
[13] | |||
| Compound Name |
(4r)-4-{3-[Hydroxy(Methyl)amino]-3-Oxopropyl}-L-Glutamic Acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312403; 3ZA; BDBM50426285; Q27454276
Click to Show/Hide
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||||
| Activity |
IC50 > 3000000 nM
|
[7] | |||
| Compound Name |
1,2,4-Butanetricarboxylic acid, 4-amino-, (2S,4S)-
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL479797; BDBM50252047; (2S,4S)-4-(2-Hydroxy-2-oxoethyl)glutamic Acid; (2S,4S)-4-aminobutane-1,2,4-tricarboxylic acid
Click to Show/Hide
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||||
| Activity |
Ki > 3000000 nM
|
[13] | |||
| Compound Name |
(2S,4S)-4-(Hydroxymethyl)glutamic Acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL500448; BDBM50251951; ZINC40979474; (2S,4S)-2-amino-4-(hydroxymethyl)pentanedioic acid
Click to Show/Hide
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||||
| Activity |
IC50 = 3000000 nM
|
[13] | |||
| Compound Name |
(2S,4R)-4-(3-Amino-3-oxopropyl)glutamic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL479804; BDBM50252050; ZINC40933343; (2S,4R)-2-amino-4-(3-amino-3-oxopropyl)pentanedioic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 3000000 nM
|
[13] | |||
| Compound Name |
(2S,4R)-4-(3-Propylamino-3-oxopropyl)glutamic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL494878; BDBM50252662; ZINC40957070
Click to Show/Hide
|
||||
| Activity |
IC50 > 3000000 nM
|
[13] | |||
| Compound Name |
Click to Show/Hide
|
Compound Info | |||
| Activity |
IC50 > 1000000 nM
|
[11] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | beta-Sulfonamido Functionalized Aspartate Analogues as Excitatory Amino Acid Transporter Inhibitors: Distinct Subtype Selectivity Profiles Arising from Subtle Structural Differences. J Med Chem. 2016 Oct 13;59(19):8771-86. | ||||
| REF 2 | Chemoenzymatic synthesis of a series of 4-substituted glutamate analogues and pharmacological characterization at human glutamate transporters subtypes 1-3. J Med Chem. 2005 Dec 15;48(25):7980-92. | ||||
| REF 3 | Synthesis and biological activities of aryl-ether-, biaryl-, and fluorene-aspartic acid and diaminopropionic acid analogs as potent inhibitors of the high-affinity glutamate transporter EAAT-2. Bioorg Med Chem Lett. 2005 Nov 15;15(22):4985-8. | ||||
| REF 4 | Syntheses of optically pure beta-hydroxyaspartate derivatives as glutamate transporter blockers. Bioorg Med Chem Lett. 2000 Nov 6;10(21):2407-10. | ||||
| REF 5 | Chemoenzymatic Synthesis and Pharmacological Characterization of Functionalized Aspartate Analogues As Novel Excitatory Amino Acid Transporter Inhibitors. J Med Chem. 2018 Sep 13;61(17):7741-7753. | ||||
| REF 6 | Discovery of the first selective inhibitor of excitatory amino acid transporter subtype 1. J Med Chem. 2009 Feb 26;52(4):912-5. | ||||
| REF 7 | Chemoenzymatic synthesis of new 2,4-syn-functionalized (S)-glutamate analogues and structure-activity relationship studies at ionotropic glutamate receptors and excitatory amino acid transporters. J Med Chem. 2013 Feb 28;56(4):1614-28. | ||||
| REF 8 | Structure-activity relationship study of first selective inhibitor of excitatory amino acid transporter subtype 1: 2-Amino-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (UCPH-101). J Med Chem. 2010 Oct 14;53(19):7180-91. | ||||
| REF 9 | Rational design and enantioselective synthesis of (1R,4S,5R,6S)-3-azabicyclo[3.3.0]octane-4,6-dicarboxylic acid - a novel inhibitor at human glutamate transporter subtypes 1, 2, and 3. J Med Chem. 2006 Jan 12;49(1):172-8. | ||||
| REF 10 | Stereoselective chemoenzymatic synthesis of the four stereoisomers of l-2-(2-carboxycyclobutyl)glycine and pharmacological characterization at human excitatory amino acid transporter subtypes 1, 2, and 3. J Med Chem. 2006 Nov 2;49(22):6532-8. | ||||
| REF 11 | Novel 1-hydroxyazole bioisosteres of glutamic acid. Synthesis, protolytic properties, and pharmacology. J Med Chem. 2002 Jan 3;45(1):19-31. | ||||
| REF 12 | The lignan (-)-hinokinin displays modulatory effects on human monoamine and GABA transporter activities. J Nat Prod. 2013 Oct 25;76(10):1889-95. | ||||
| REF 13 | Chemo-enzymatic synthesis of (2S,4R)-2-amino-4-(3-(2,2-diphenylethylamino)-3-oxopropyl)pentanedioic acid: a novel selective inhibitor of human exci... J Med Chem. 2008 Jul 24;51(14):4085-92. | ||||
| REF 14 | New 4-Functionalized Glutamate Analogues Are Selective Agonists at Metabotropic Glutamate Receptor Subtype 2 or Selective Agonists at Metabotropic Glutamate Receptor Group III. J Med Chem. 2016 Feb 11;59(3):914-24. | ||||
| REF 15 | Structure-activity relationship study of selective excitatory amino acid transporter subtype 1 (EAAT1) inhibitor 2-amino-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (UCPH-101) and absolute configurational assignment using infrared and vibrational circular dichroism spectroscopy in combination with ab initio Hartree-Fock calculations. J Med Chem. 2012 Jun 14;55(11):5403-12. | ||||
| REF 16 | Design and Synthesis of a Series of l-trans-4-Substituted Prolines as Selective Antagonists for the Ionotropic Glutamate Receptors Including Functional and X-ray Crystallographic Studies of New Subtype Selective Kainic Acid Receptor Subtype 1 (GluK1) Antagonist (2S,4R)-4-(2-Carboxyphenoxy)pyrrolidine-2-carboxylic Acid. J Med Chem. 2017 Jan 12;60(1):441-457. | ||||
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