Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T87109 | Target Info | |||
| Target Name | Casein kinase I delta (CSNK1D) | ||||
| Synonyms |
Tau-protein kinase CSNK1D; HCKID; Casein kinase I isoform delta; CKId; CKI-delta
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|
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| Target Type | Preclinical Target | ||||
| Gene Name | CSNK1D | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 29 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
4-[2-(4-Ethynylphenyl)-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-methylsulfanylpyrimidine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3314286; BDBM50045571
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|
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| Activity |
IC50 = 66300 nM
|
[1] | |||
| Compound Name |
6-(2,9-Diazaspiro[5.5]undecan-9-Yl)-9h-Purine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2420911; BDBM50439463; 9-(9H-purin-6-yl)-2,9-diazaspiro[5.5]undecane; Q27451706; 15I
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| Activity |
IC50 = 97000 nM
|
[2] | |||
| Compound Name |
N-[3-[4-[[Amino-[4-chloro-3-(trifluoromethyl)anilino]methylidene]amino]anilino]phenyl]acetamide;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3290699; BDBM50019436
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Sodium;2-[4-[2-(4-fluorophenyl)-3-(2-methylsulfanylpyrimidin-4-yl)imidazo[1,2-a]pyrimidin-7-yl]triazol-1-yl]acetate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3314273
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-(4-Fluorophenyl)-3-(2-methylsulfanylpyrimidin-4-yl)imidazo[1,2-a]pyrimidin-7-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3314271; SCHEMBL6217129; BDBM50045555
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
1-[3-[[4-(Diaminomethylideneamino)phenyl]methyl]phenyl]-2-phenylguanidine;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3290691; BDBM50019454
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
1-[3-[4-(Diaminomethylideneamino)phenoxy]phenyl]-2-phenylguanidine;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3290690; BDBM50019453
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
2-[3-[4-(Diaminomethylideneamino)benzoyl]phenyl]guanidine;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3290432; BDBM50019442
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
N-[3-[4-[[Amino-[4-chloro-3-(trifluoromethyl)anilino]methylidene]amino]phenoxy]phenyl]acetamide;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3290698; BDBM50019432
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Disodium;2-[4-[2-(4-fluorophenyl)-3-(2-methylsulfanylpyrimidin-4-yl)imidazo[1,2-a]pyrimidin-7-yl]triazol-1-yl]ethyl-dioxido-oxo-lambda5-phosphane
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3314275
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
N-[4-[3-(4,5-Dihydro-1H-imidazol-2-ylamino)phenoxy]phenyl]-4,5-dihydro-1H-imidazol-2-amine;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3290435; BDBM50019446
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
7-Ethynyl-2-(4-fluorophenyl)-3-(2-methylsulfanylpyrimidin-4-yl)imidazo[1,2-a]pyrimidine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3314272; BDBM50045556
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-[4-[3-(Diaminomethylideneamino)anilino]phenyl]-1-phenylguanidine;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3290689; BDBM50019452
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
2-(4-Fluorophenyl)-3-[2-[[(1S)-1-phenylethyl]amino]pyrimidin-4-yl]imidazo[1,2-a]pyrimidin-7-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3120970; SCHEMBL13823117; BDBM50045580
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
1-[4-Chloro-3-(trifluoromethyl)phenyl]-2-[4-[3-(diaminomethylideneamino)phenoxy]phenyl]guanidine;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3290692; BDBM50019455
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
2-[4-[3-(Diaminomethylideneamino)benzoyl]phenyl]-1-phenylguanidine;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3290687; BDBM50019450
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
2-[3-[[4-(Diaminomethylideneamino)phenyl]methyl]phenyl]guanidine;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3290433; BDBM50019444
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
1-[4-Chloro-3-(trifluoromethyl)phenyl]-2-[4-[3-(diaminomethylideneamino)benzoyl]phenyl]guanidine;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3290693; BDBM50019456
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
[3-(4,5-Dihydro-1H-imidazol-2-ylamino)phenyl]-[4-(4,5-dihydro-1H-imidazol-2-ylamino)phenyl]methanone;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3290436; BDBM50019447
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
2-[4-Chloro-3-(trifluoromethyl)phenyl]-1-[3-[4-(diaminomethylideneamino)phenoxy]phenyl]guanidine;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3290696; BDBM50019428
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
2-[3-[4-(Diaminomethylideneamino)phenoxy]phenyl]guanidine;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3290431; BDBM50019441
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
N-[4-[[3-(4,5-Dihydro-1H-imidazol-2-ylamino)phenyl]methyl]phenyl]-4,5-dihydro-1H-imidazol-2-amine;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3290437; BDBM50019448
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
2-[3-[4-(Diaminomethylideneamino)anilino]phenyl]guanidine;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3290434; BDBM50019445
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
2-[4-[4-(Diaminomethylideneamino)phenoxy]phenyl]guanidine;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3290430; BDBM50019437
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
2-[4-Chloro-3-(trifluoromethyl)phenyl]-1-[3-[[4-(diaminomethylideneamino)phenyl]methyl]phenyl]guanidine;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3290697; BDBM50019429
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
1-[4-Chloro-3-(trifluoromethyl)phenyl]-2-[4-[3-(diaminomethylideneamino)anilino]phenyl]guanidine;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3290695; BDBM50019460
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
2-[4-[[3-(Diaminomethylideneamino)phenyl]methyl]phenyl]-1-phenylguanidine;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3290688; BDBM50019451
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
2-[4-[3-(Diaminomethylideneamino)phenoxy]phenyl]-1-phenylguanidine;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3290438; BDBM50019449
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
1-[4-Chloro-3-(trifluoromethyl)phenyl]-2-[4-[[3-(diaminomethylideneamino)phenyl]methyl]phenyl]guanidine;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3290694; BDBM50019459
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 1 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
6-(1,9-Diazaspiro[5.5]undecan-9-Yl)-9h-Purine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2420909; BDBM50439464; 9-(9H-purin-6-yl)-1,9-diazaspiro[5.5]undecane; Q27465376; SIJ
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|
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| Activity |
IC50 = 238000 nM
|
[2] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Synthesis and structure-activity relationships of 4-fluorophenyl-imidazole p38alpha MAPK, CK1 and JAK2 kinase inhibitors. Bioorg Med Chem Lett. 2014 Aug 1;24(15):3412-8. | ||||
| REF 2 | Synthesis and evaluation of heteroaryl substituted diazaspirocycles as scaffolds to probe the ATP-binding site of protein kinases. Bioorg Med Chem. 2013 Sep 15;21(18):5707-24. | ||||
| REF 3 | Guanidinium-based derivatives: searching for new kinase inhibitors. Eur J Med Chem. 2014 Jun 23;81:427-41. | ||||
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