Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T88185 | Target Info | |||
| Target Name | Nicotinic acid receptor (HCAR2) | ||||
| Synonyms |
Niacin receptor 1; NIACR1; Hydroxycarboxylic acid receptor 2; HM74A; HCA2; GPR109A; G-protein coupled receptor HM74A; G-protein coupled receptor 109A
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| Target Type | Successful Target | ||||
| Gene Name | HCAR2 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 10 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Nicotinamide
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Approved | Compound Info | ||
| Synonyms |
Aminicotin; Amixicotyn; Amnicotin; Benicot; Dipegyl; Endobion; Enduramide; Hansamid; Mediatric; Niacevit; Niacinamide; Niacotinamide; Niamide; Nicamina; Nicamindon; Nicasir; Nicobion; Nicofort; Nicogen; Nicomidol; Nicosylamide; Nicota; Nicotamide; Nicotilamide; Nicotililamido; Nicotinamid; Nicotinamida; Nicotinamidum; Nicotinsaeureamid; Nicotinsaureamid; Nicotol; Nicotylamide; Nicotylamidum; Nicovit; Nicovitina; Nicovitol; Nicozymin; Nikasan; Nikazan; Nikotinamid; Nikotinsaeureamid; Niocinamide; Niozymin; Papulex; Pelmin; Pelmine; Savacotyl; Amid kyseliny nikotinove; Amid kyseliny nikotinove [Czech]; Amide PP; Astra Brand of Niacinamide; Austrovit PP; Delonin amide; Factor pp; Inovitan PP; Jenapharm Brand of Niacinamide; Merck Brand of Niacinamide; Niacinamide Astra Brand; Niacinamide Jenapharm Brand; Niacinamide Merck Brand; Niacinamide Pharmagenix Brand; Niacinamide [USAN]; Niavit PP; Nicotine acid amide; Nicotine amide; Nicotinic acid amide; Nicotinic amide; Nicotinsaureamid Jenapharm; Nicotinsaureamid [German]; Nikotinsaeureamid [German]; Pelonin amide; Pharmagenix Brand of Niacinamide; Vitamin B; Vitamin PP; Witamina PP; Nicosan 2; Vitamin H1; B 3, Vitamin; B3, Vitamin; Beta-Pyridinecarboxamide; Jenapharm, Nicotinsaureamid; Nandervit-N; Niacin-Vitamin B3; Niacinamide (USP); Nicotinamida [INN-Spanish]; Nicotinamide (Niacinamide); Nicotinamidum [INN-Latin]; Niko-tamin; PP-Faktor; Vi-Nicotyl; Vitamin B (VAN); M-(Aminocarbonyl)pyridine; Niacinamide, Nicotinic acid amide, Nicotinamide; Nicotinamide (JP15/INN); Nicotinamide, niacin, vitamin B3; Nicotinamide-carbonyl-14C; Pyridine-3-carboxamide; Pyridine-3-carboxylic acid amide; 3 Pyridinecarboxamide; 3-Carbamoylpyridine; 3-Pyridinecarboxamide; 3-Pyridinecarboxylic acid amide
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| Activity |
IC50 = 67300 nM
|
[1] | |||
| Compound Name |
2-(3-Phenylpropyl)pyrido[2,3-d]pyrimidin-4(3H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1223822; BDBM50325902
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
5-Methyl-4-oxo-5-vinyl-4,5-dihydro-furan-2-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL375534; BDBM50208133
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| Activity |
EC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
5-Ethyl-5-methyl-4-oxo-4,5-dihydro-furan-2-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL223704; BDBM50208118
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| Activity |
EC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
2-Benzylpyrido[2,3-d]pyrimidin-4(3H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1223820; BDBM50325905
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
2-(3-Phenoxypropyl)pyrido[2,3-d]pyrimidin-4(3H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1223879; BDBM50325906
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
2-Phenethylpyrido[2,3-d]pyrimidin-4(3H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1223821; SCHEMBL1871754; BDBM50325898; ZINC58583595; 2-(2-phenylethyl)-1H-pyrido[2,3-d]pyrimidin-4-one; 2-(2-phenylethyl)pyrido[2,3-d]pyrimidin-4(3H)-one
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
2-[3-(1,3-Benzodioxol-5-yl)propanoylamino]cyclohexene-1-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3297876; BDBM50022073
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| Activity |
EC50 = 51600 nM
|
[4] | |||
| Compound Name |
2-(1-(Naphthalen-2-yl)piperazine-4-carboxamido)benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL252505; SCHEMBL13666087; BDBM50227774
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| Activity |
IC50 = 76000 nM
|
[5] | |||
| Compound Name |
1-Oxaspiro[4.4]non-2-ene-2-carboxylic acid, 4-oxo-
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL223705; BDBM50208129; 5-spirocyclopentyl-4,5-dihydro-furan-2-carboxylic acid
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| Activity |
EC50 ~ 100000 nM
|
[3] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 18 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
3,5-dihydroxybenzoic acid
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Investigative | Compound Info | ||
| Synonyms |
NSC 22948; alpha-resorcylic acid; 5-carboxyresorcinol
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| Activity |
EC50 > 1000000 nM
|
[6] | |||
| Compound Name |
3-Hydroxybenzoic acid
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Investigative | Compound Info | ||
| Synonyms |
M-HYDROXYBENZOIC ACID; m-Salicylic acid; 3-Carboxyphenol; Benzoic acid, 3-hydroxy-; m-Hba; Benzoic acid, m-hydroxy-; meta-Hydroxybenzoic acid; Acido m-idrossibenzoico; 3-Hydroxy benzoic acid; Kyselina 3-hydroxybenzoova; 3-hydroxy-benzoic acid; UNII-2ZFW40OJ7U; MFCD00002506; NSC 55746; 2ZFW40OJ7U; CHEMBL65369; m-hydroxybenzoate; 3-Hydroxybenzoic acid, 99%; Acido m-idrossibenzoico [Italian]; Kyselina 3-hydroxybenzoova [Czech]; EINECS 202-726-5; BRN 0508160; m-salicylate; AI3-03110; 3-hydroxy benzoate; meta-hydroxybenzoate; meta-salicylic acid; Benzoic acid, 3-hydroxy-, ion(1-); 3-hydroxybenzoic-acid; metahydroxybenzoic acid; PubChem9161; 3-Hydroxybenzoate, II; Enamine_005356; DSSTox_CID_1610; bmse000324; DSSTox_RID_76235; DSSTox_GSID_21610; SCHEMBL40078; KSC349K8N; DTXSID6021610; HMS1409D10; ZINC388754; ACMC-209795; KS-000000YX; NSC55746; Tox21_200527; ANW-13671; BBL011983; BDBM50336491; KM3494; NSC-55746; s6367; SBB058844; STL163473; AKOS000118958; CS-W004049; HY-W004049; MCULE-3607182166; PS-5406; NCGC00248676-01; NCGC00258081-01; AK-50288; SC-07532; 3-Hydroxybenzoic acid, analytical standard; AB0007855; DB-028515; FT-0600874; ST51038596; 3-Hydroxybenzoic acid, ReagentPlus(R), 99%; C00587; AE-562/40227537; Q2823216; W-100054; 3-Hydroxybenzoic acid, Vetec(TM) reagent grade, 98%; F9995-1635; UNII-I3P9R8317T component IJFXRHURBJZNAO-UHFFFAOYSA-N; 713EC407-4844-477D-8207-DBD66E398D2C
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| Activity |
EC50 = 215000 nM
|
[6] | |||
| Compound Name |
5-Hydroxynicotinic acid
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Investigative | Compound Info | ||
| Synonyms |
5-hydroxypyridine-3-carboxylic acid; 3-Pyridinecarboxylic acid, 5-hydroxy-; 5-Hydroxy-nicotinic acid; 5-Hydroxy-3-pyridinecarboxylic acid; 5-hydroxy nicotinic acid; MFCD00129117; CHEMBL2146902; 5-hydroxynicotinicacid; BRN 0115847; NICOTINIC ACID, 5-HYDROXY-; PubChem2415; ACMC-209gz9; Oprea1_058796; Oprea1_193943; 5-22-05-00113 (Beilstein Handbook Reference); KSC202E8T; SCHEMBL186161; 5-Hydroxynicotinic acid, 97%; CTK1A2289; 5-hydroxypyridinium-3-carboxylate; DTXSID50182143; 5-hydroxypyridine-3-carboxylicacid; HMS1671H22; ZINC332673; ACT02416; BCP27371; EBD49093; KS-000006OW; 3-Hydroxypyridine-5-carboxylic acid; ANW-26275; BBL010930; BDBM50391823; NSC606891; RW1130; SBB010273; STK531022; STK801985; 3-pyridinecarboxylic acid, 5-hydroxy; AKOS000272822; AKOS005463460; AC-2839; ACN-049106; CS-W009148; LS20727; MCULE-4896018532; NSC-606891; PB33816; PS-5446; NCGC00342404-01; AK-25698; BP-21442; BR-25698; SC-03080; SY003082; 3-HYDROXY-5-PYRIDINECARBOXYLIC ACID; AB0006010; DB-009085; 3-PYRIDINECARBOXYLIC ACID,5-HYDROXY-; AM20051033; FT-0602367; FT-0621168; ST50258394; 3-Pyridinecarboxylic acid, 5-hydroxy- (9CI); EN300-73559; C-5668; AB01334129-02; 828H713; AE-848/00984004; J-400705; Q27455772; Z57124104
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| Activity |
EC50 = 368000 nM
|
[6] | |||
| Compound Name |
5-Methyl-1H-pyrazole-3-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
3-methyl-1H-pyrazole-5-carboxylic acid; 5-METHYLPYRAZOLE-3-CARBOXYLIC ACID; 3-Methylpyrazole-5-carboxylic acid; 5-Methyl-2H-pyrazole-3-carboxylic acid; AS057278; UNII-U71778T48T; 5-methylpyrazole-3-carboxylicacid; 3-METHYL-1H-PYRAZOLE-5-CARBOXYLICACID; MFCD00462235; Pyrazole-3-carboxylic acid, 5-methyl-; CHEMBL391574; 5-methyl-pyrazole-3-carboxylic acid; U71778T48T; 5(OR 3)-METHYL-PYRAZOLE-3(OR 5)-CARBOXYLIC ACID; BRN 0002906; U 19425; LITHIUMTANTALATE; PubChem7842; 5-Methyl-2H-pyrazole-3-carboxylicacid; 1H-Pyrazole-3-carboxylicacid, 5-methyl-; AS-057278; 5-carb-oxy-3-methylpyrazole; 4-25-00-00731 (Beilstein Handbook Reference); 5-methyl-3-carboxyl-pyrazole; KSC236G1N; SCHEMBL220072; ARONIS001555; CTK1D6316; CTK8D4155; KS-00003UZR; 3-methyl-5-pyrazolecarboxylicacid; DTXSID50193198; NSC1408; 3-Methyl-5-Pyrazolecarboxylic Acid; ACN-P001119; ACT03800; ALBB-006653; CS-D1083; KS-000006KI; NSC-1408; ZINC3982495; ANW-50811; BBL008120; BDBM50211362; CL3431; HTS000463; MFCD00090754; s5434; SBB019482; STK012600; AKOS000145258; AKOS000265556; AKOS025394813; ACN-001037; ACN-001119; AS-5392; CCG-266102; LS20295; LS20817; MCULE-9971793748; PB13019; Pyrazole-5-carboxylic acid, 3-methyl-; QC-3945; SB19897; SDCCGMLS-0065489.P001; 1H-Pyrazole-3-carboxylicacid,5-methyl-; NCGC00326251-01; AC-23127; AK-27812; AK-76071; AM804242; BP-10275; BR-27812; SC-46128; SC-94258; SY007408; 3-Methylpyrazole-5-carboxylic acid, 97%; 5-Methyl-1H-pyrazole-3-carboxylic acid #; AB0001093; DB-011354; A6735; A9209; AM20100068; BB 0219106; BB 0253991; FT-0601812; FT-0601814; ST45038371; W6074; EN300-41425; L-2616; S-3039; AB00672916-01; AB00672916-03; 1Y-0803; 402M619; U-19425; J-512825; J-517731; Q27144868; F0917-7550; F2120-0002; Z752370868
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| Activity |
IC50 = 434000 nM
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[1] | |||
| Compound Name |
3-Bromo-5-hydroxybenzoic acid
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Investigative | Compound Info | ||
| Synonyms |
Benzoic acid, 3-bromo-5-hydroxy-; 3-bromo-5-hydroxy benzoic acid; CHEMBL2146909; 3-BROMO-5-HYDROXYBENZOICACID; Benzoic acid,3-bromo-5-hydroxy-; ACMC-209ckn; SCHEMBL200289; 3-bromo-5-hydroxy-benzoic acid; 5-hydroxy-3-bromo-benzoic acid; CTK4C2222; DTXSID10577677; KS-000017MM; ANW-20565; BBL103606; BDBM50391815; MFCD06797980; STL557416; ZINC12956775; 3-Bromo-5-hydroxybenzoic acid, 97%; 5-BROMO-3-HYDROXYBENZOIC ACID; AKOS015834264; AB29744; AS06301; CM10203; CS-W014828; AK-59149; AS-19422; SC-53216; AB0033968; B4740; X8047; B-3141; J-007395
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| Activity |
EC50 > 1000000 nM
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[6] | |||
| Compound Name |
3-Hydroxy-5-(trifluoromethyl)benzoic Acid
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Investigative | Compound Info | ||
| Synonyms |
3-Hydroxy-5-trifluoromethylbenzoic acid; CHEMBL2146907; Benzoic acid, 3-hydroxy-5-(trifluoromethyl)-; MFCD07368783; 3-Hydroxy-5-trifluoromethyl-benzoic acid; 3-hydroxy-5-trifluoromethylbenzoicacid; ACMC-1CPRZ; KSC496I2D; SCHEMBL477824; CTK3J6421; KS-00000NMX; DTXSID00382459; ACT00885; ANW-72881; BBL101599; BDBM50391821; CL8089; SBB093590; STL555395; ZINC15442784; AKOS005259697; AB32076; AM84002; CM12815; CS-W015347; FS-2057; 5-hydroxy-3-trifluoromethyl-benzoic acid; AC-26052; AK-34710; BR-34710; SC-52492; 5-hydroxy-3-(trifluoromethyl)benzoic acid; AB0024236; A5872; FT-0651162; W5461; S-5405; 328H698; Z1741967079
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| Activity |
EC50 > 1000000 nM
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[6] | |||
| Compound Name |
3-Hydroxyphenylboronic acid
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Investigative | Compound Info | ||
| Synonyms |
(3-hydroxyphenyl)boronic Acid; 3-Hydroxybenzeneboronic acid; MFCD01074603; 3-Hydroxyphenylboronicacid; M-HYDROXYPHENYLBORONIC ACID; Boronic acid, (3-hydroxyphenyl)-; CHEMBL2146990; 3-Hydroxyphenylboronic acid, 97%; PubChem1728; 3-BORONOPHENOL; ACMC-209qip; 3-hydroxyphenyboronic acid; SCHEMBL8884; 3-hydroxy phenylboronic acid; 3-hydroxy-phenylboronic acid; 3-hydroxyphenyl boronic acid; 3-hydroxyphenyl-boronic acid; 3-hydroxy benzeneboronic acid; 3-hydroxylphenyl boronic acid; KSC447S9P; 3-hydroxy phenyl boronic acid; (3-hydroxyphenyl) boronic acid; (3-hydroxyphenyl)-boronic acid; (3-hydroxy-phenyl)-boronic acid; CTK3E7997; WFWQWTPAPNEOFE-UHFFFAOYSA-; DTXSID90370249; M-HYDROXYBENZENEBORONIC ACID; ACN-S003923; ACT02211; BCP03518; Boronicacid, B-(3-hydroxyphenyl)-; KS-000000KW; ANW-38639; BBL100525; BDBM50391826; SBB052523; STL554319; AKOS004116323; HEX-2-ENEDIOICACIDDIMETHYLESTER; ZINC169743259; AB08061; AS-2488; CS-W002734; LS10839; QC-1420; VB10320; 3-Hydroxyphenylboronic acid, >=95.0%; NCGC00249443-01; AC-24801; AK-44803; BP-20369; BR-44803; SC-07076; SY003747; AB0010406; DB-031699; (3-(Boc-aminomethyl)-3-hydroxyoxetan-3-ol; AM20050286; FT-0615831; B-5047; 199H186; Q-102215
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| Activity |
EC50 > 1000000 nM
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[6] | |||
| Compound Name |
3-Hydroxy-5-methoxybenzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2146904; Benzoic acid, 3-hydroxy-5-methoxy-; SCHEMBL618373; CTK0A0561; DTXSID30428677; 3-hydroxy-5-methoxy-benzoic acid; ZINC5046498; BDBM50391818; MFCD06655980; AKOS000277131; AB25434; AK134172; AS-50131; DA-08627; SC-71286; FT-0721622
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| Activity |
EC50 > 1000000 nM
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[6] | |||
| Compound Name |
3-Chloro-5-hydroxybenzoic acid
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Investigative | Compound Info | ||
| Synonyms |
3-CHLORO-5-HYDROXY-BENZOIC ACID; Benzoic acid, 3-chloro-5-hydroxy-; CHEMBL2146910; Benzoic acid,3-chloro-5-hydroxy-; MFCD04114327; 3-Chloro-5-hydroxybenzoicacid; ACMC-209lbs; 3-Chloro-5-hydroxy BA; 3-hydroxy-5-chlorobenzoic acid; SCHEMBL1999585; CTK4J9210; DTXSID50517335; KS-00000K5A; ZINC2599133; 3-chloranyl-5-oxidanyl-benzoic acid; ANW-31910; BDBM50391825; CL8082; s5400; SBB052708; AKOS006293910; AB18080; AM84171; CCG-266375; CS-W017584; AK107678; SC-73033; SY025109; TS-02354; AB0033979; DB-006403; FT-0650742; X8059; K-9757; 3-Chloro-5-hydroxybenzoic acid, >=97% (HPLC); 984C364; A829885
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| Activity |
EC50 > 1000000 nM
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[6] | |||
| Compound Name |
5-Hydroxy-3-phenylbenzoic acid
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Investigative | Compound Info | ||
| Synonyms |
5-Hydroxy-[1,1'-biphenyl]-3-carboxylic acid; CHEMBL2146906; ACMC-209ih9; 3-hydroxy-5-phenylbenzoic acid; SCHEMBL18706550; CTK4H4648; DTXSID50688498; 4430AB; ANW-28219; BDBM50391816; MFCD18086680; ZINC65349369; AKOS015856249; 5-Hydroxy-1,1'-biphenyl-3-carboxylic acid; 5-Hydroxy[1,1'-biphenyl]-3-carboxylic acid; A-3342
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| Activity |
EC50 > 1000000 nM
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[6] | |||
| Compound Name |
3-t-Butyl-5-hydroxybenzoic acid
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Investigative | Compound Info | ||
| Synonyms |
3-TERT-BUTYL-5-HYDROXYBENZOIC ACID; CHEMBL2146485; 3-(tert-Butyl)-5-hydroxybenzoic acid; Benzoic acid,3-(1,1-dimethylethyl)-5-hydroxy-; 3-T-BUTYL-5-HYDROXYBENZOICACID; SCHEMBL1188570; CTK4J1756; DTXSID20618227; BDBM50391817; ZINC14986119; AKOS006326249; MB07578; W-2747; Benzoic acid, 3-(1,1-dimethylethyl)-5-hydroxy-
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| Activity |
EC50 > 1000000 nM
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[6] | |||
| Compound Name |
5-(2H-Tetrazol-5-yl)benzene-1,3-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2146993; BDBM50391829
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| Activity |
EC50 > 1000000 nM
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[6] | |||
| Compound Name |
3-Cyano-5-hydroxybenzoic acid
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Investigative | Compound Info | ||
| Synonyms |
Benzoic acid, 3-cyano-5-hydroxy-; CHEMBL2146908; SCHEMBL2562951; 2257AJ; BDBM50391820; ZINC95558795; AB71614; AS06302; CM10204; MCULE-2254411035; NE40937; DA-23707; FT-0708661; Z1815157430
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| Activity |
EC50 > 1000000 nM
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[6] | |||
| Compound Name |
5-Hydroxy-1-oxidopyridin-1-ium-3-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2146903; BDBM50391824
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| Activity |
EC50 > 1000000 nM
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[6] | |||
| Compound Name |
3-Hydroxy-5-methylbenzoic acid
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Investigative | Compound Info | ||
| Synonyms |
3-Hydroxy-5-methyl-benzoic acid; 3,5-Cresotic acid; Benzoic acid, 3-hydroxy-5-methyl-; CHEMBL2146905; 3-Hydroxy-5-methyl benzoic acid; 3-methyl-5-oxidanyl-benzoic acid; MFCD09833213; 3-hydroxy-5-methylbenzoicacid; NSC28456; PubChem18175; 5-Hydroxy-m-toluic acid; KSC494S9N; SCHEMBL987044; 3-hydroxy-5-methylbenzoic aicd; 3-methyl-5-hydroxy-benzoic acid; CTK3J4996; KS-00000NMY; DTXSID00207219; ACT07354; ZINC1646464; AC-944; ANW-48428; BBL101580; BDBM50391819; CL8088; NSC-28456; STL555376; 3-HYDROX-5-METHYLBENZOIC ACID; AKOS005259855; 3-HYDROXY-5-METHYL-BENZOICACID; AB52735; AM84165; FS-2415; MCULE-6111297909; AK-47209; BR-47209; QC-10603; SY012261; AB0030856; DB-072503; CS-0030557; FT-0757074; X3116; EN300-84081; S-5999; 585H819; W-203198; Z1255523409
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| Activity |
EC50 > 1000000 nM
|
[6] | |||
| Compound Name |
3,5-Dihydroxyphenylphosphonic Acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2146991; SCHEMBL6395721; BDBM50391827; (3,5-dihydroxyphenyl)phosphonic acid
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| Activity |
EC50 > 1000000 nM
|
[6] | |||
| Compound Name |
3,5-Dihydroxyphenyl(Methyl)Phosphinic Acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2146992; SCHEMBL20518823; BDBM50391828; (3,5-dihydroxyphenyl)-methylphosphinic acid
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| Activity |
EC50 > 1000000 nM
|
[6] | |||
| Compound Name |
3-Fluoro-5-hydroxybenzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2146989; MFCD11846515; 3-Fluoro-5-hydroxybenzoicAcid; 3-fluoro-5-hydroxy-benzoic Acid; ACMC-209q89; SCHEMBL1264934; CTK5F6202; KS-00000CYD; DTXSID60459358; ANW-38263; BDBM50391822; CL8086; SBB087118; ZINC36533778; AKOS006342851; AB64637; CS-W005392; FS-3463; AK-67889; SC-49447; SY030488; 3-Fluoro-5-hydroxybenzoic acid, AldrichCPR; AB0027054; FT-0682919; W8841; B-5308
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| Activity |
EC50 > 1000000 nM
|
[6] | |||
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Nicotinic acid receptor agonists differentially activate downstream effectors. J Biol Chem. 2007 Jun 22;282(25):18028-18036. | ||||
| REF 2 | Pyrido pyrimidinones as selective agonists of the high affinity niacin receptor GPR109A: optimization of in vitro activity. Bioorg Med Chem Lett. 2010 Sep 15;20(18):5426-30. | ||||
| REF 3 | Analogues of acifran: agonists of the high and low affinity niacin receptors, GPR109a and GPR109b. J Med Chem. 2007 Apr 5;50(7):1445-8. | ||||
| REF 4 | Synthesis and evaluation of (E)-2-(acrylamido)cyclohex-1-enecarboxylic acid derivatives as HCA1, HCA2, and HCA3 receptor agonists. Bioorg Med Chem. 2014 Jul 15;22(14):3654-69. | ||||
| REF 5 | Discovery of orally bioavailable and novel urea agonists of the high affinity niacin receptor GPR109A. Bioorg Med Chem Lett. 2007 Dec 15;17(24):6723-8. | ||||
| REF 6 | Identification of Hydroxybenzoic Acids as Selective Lactate Receptor (GPR81) Agonists with Antilipolytic Effects. ACS Med Chem Lett. 2012 Jun 11;3(8):637-9. | ||||
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