Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T90987 | Target Info | |||
| Target Name | ADAM metallopeptidase with thrombospondin 1 (ADAMTS1) | ||||
| Synonyms |
METH1; METH-1; KIAA1346; ADAMTS-1; ADAM-TS1; ADAM-TS 1
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| Target Type | Literature-reported Target | ||||
| Gene Name | ADAMTS1 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 6 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
CID 66560022
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2164122; SCHEMBL17809497; BDBM50395678
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
CID 66559934
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2164120; SCHEMBL17814861; BDBM50395680
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-[[(2R)-1-[4-[(1-Methylimidazol-4-yl)methylamino]-6-(propylamino)-1,3,5-triazin-2-yl]pyrrolidin-2-yl]methyl]-4-propylbenzenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2164094; BDBM50395675
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
CID 66560021
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2164121; SCHEMBL17809496; BDBM50395679
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
CID 66560479
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2164113; SCHEMBL19280619; BDBM50395676
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
CID 66560389
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2164111; SCHEMBL19280440; BDBM50395677
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Discovery of highly potent and selective small molecule ADAMTS-5 inhibitors that inhibit human cartilage degradation via encoded library technology (ELT). J Med Chem. 2012 Aug 23;55(16):7061-79. | ||||
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