Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T93440 | Target Info | |||
| Target Name | Interleukin 6 receptor (IL6R) | ||||
| Synonyms |
Membrane glycoprotein; Interleukin-6 receptor; IL-6R; IL-6 receptor
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| Target Type | Successful Target | ||||
| Gene Name | IL6R; IL6ST | ||||
| Biochemical Class | Cytokine receptor | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 2 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(4S)-3-[(2S,3S)-3-Hydroxy-2-methyl-4-methylideneundecanoyl]-4-propan-2-yl-1,3-oxazolidin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3763626; BDBM50145190
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| Activity | Interleukin-6 receptor subunit beta |
IC50 ~ 100000 nM
|
[1] | ||
| Compound Name |
(4S)-3-[(2S,3S)-3-Hydroxy-2,4-dimethylpent-4-enoyl]-4-propan-2-yl-1,3-oxazolidin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3765446; BDBM50145196; (4S)-3-[(2S,3S)-3-Hydroxy-2,4-dimethyl-4-pentenoyl]-4beta-isopropyloxazolidin-2-one
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| Activity | Interleukin-6 receptor subunit beta |
IC50 ~ 100000 nM
|
[1] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structure-activity relationship study of a series of novel oxazolidinone derivatives as IL-6 signaling blockers. Bioorg Med Chem Lett. 2016 Feb 15;26(4):1282-6. | ||||
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