Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T94324 | Target Info | |||
| Target Name | Histone deacetylase 10 (HDAC10) | ||||
| Synonyms |
Polyamine deacetylase HDAC10; HD10
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| Target Type | Patented-recorded Target | ||||
| Gene Name | HDAC10 | ||||
| Biochemical Class | Carbon-nitrogen hydrolase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 25 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
SNDX-275
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Phase 3 | Compound Info | ||
| Synonyms |
Entinostat; Histone Deacetylase Inhibitor I; IN1470; MS 275; SNDX 275; MS 27-275; Ms-275; Entinostat (USAN/INN); MS-27-275; Pyridin-3-ylmethyl 4-(2-aminophenylcarbamoyl)benzylcarbamate; Pyridin-3-ylmethyl N-[[4-[(2-aminophenyl)carbamoyl]phenyl]methyl]carbamate; Pyridin-3-ylmethyl {4-[(2-aminophenyl)carbamoyl]benzyl}carbamate; Pyridin-3-ylmethyl{4-[(2-aminophenyl)carbamoyl]benzyl}carbamate; Carbamic acid, [[4-[[(2-aminophenyl)amino]carbonyl]phenyl] methyl]-, 3-pyridinylmethyl ester; Carbamic acid, [[4-[[(2-aminophenyl)carbaonyl]phenyl]methyl]-, 3-pyridinylmethyl ester; Entinostat, SNDX-275, MS-27-275, MS-275; N-(2-Aminophenyl)-4-[N-(pyridin-3-yl-methoxycarbonyl)aminomethyl]benzamide; N-(2-aminophenyl)-4-(N-(pyridin-3-ylmethoxycarbonyl)aminomethyl)benzamide; Carbamic acid, ((4-(((2-aminophenyl)amino)carbonyl)phenyl)methyl)-, 3-pyridinylmethyl ester; 3-Pyridinylmethyl ((4-(((2-aminophenyl)amino)carbonyl)phenyl)methyl)carbamate
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| Activity |
IC50 = 50100 nM
|
[1] | |||
| Compound Name |
2-(2,2-Dimethylpropanoyl)-N-hydroxy-1,3-dihydroisoindole-5-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431907; SCHEMBL1262950; BDBM50440909
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| Activity |
IC50 ~ 50000 nM
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[2] | |||
| Compound Name |
N-Hydroxy-2-(1-methylpyrrole-2-carbonyl)-1,3,4,5-tetrahydro-2-benzazepine-7-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431912; SCHEMBL1264164; BDBM50440908
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| Activity |
IC50 ~ 50000 nM
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[2] | |||
| Compound Name |
N-Hydroxy-2-(1-methylpyrrole-2-carbonyl)-3,4-dihydro-1H-isoquinoline-6-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
MPI-5a; MPI_5a; CHEMBL2431901; SCHEMBL722256; SYN1218; BCP29593; EX-A1852; BDBM50440907; ZINC68248700; DB-092801; HY-113957; CS-0064770; MPI 5a;MPI5a;HDAC6 Inhibitor;Histone Deacetylase 6
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| Activity |
IC50 ~ 50000 nM
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[3] | |||
| Compound Name |
N-Hydroxy-2-[(1-methyl-1H-pyrrol-2-yl)carbonyl]isoindoline-5-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431906; SCHEMBL1263733; BDBM50440910; N-hydroxy-2-(1-methylpyrrole-2-carbonyl)-1,3-dihydroisoindole-5-carboxamide
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| Activity |
IC50 ~ 50000 nM
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[2] | |||
| Compound Name |
2-(2,2-Dimethylpropanoyl)-N-hydroxy-3,4-dihydro-1H-isoquinoline-6-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431902; SCHEMBL1263305; BDBM50440911
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| Activity |
IC50 ~ 50000 nM
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[2] | |||
| Compound Name |
Chembl4218266
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Investigative | Compound Info | ||
| Synonyms |
N-hydroxy-4-((5-(4-methoxybenzoyl)-1H-indol-1-yl)methyl)benzamide; TQP0842; BDBM50458571
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| Activity |
IC50 = 59800 nM
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[4] | |||
| Compound Name |
(E)-3-[4-[3-(1-Adamantyl)-4-(cyanomethyl)phenyl]-3-chlorophenyl]-N-hydroxyprop-2-enamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3235790; BDBM50005730
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| Activity |
IC50 = 63900 nM
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[5] | |||
| Compound Name |
Pimelic Diphenylamide 106
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Investigative | Compound Info | ||
| Synonyms |
TC-H 106; N1-(2-aminophenyl)-N7-(4-methylphenyl)-heptanediamide; N'-(2-aminophenyl)-N-(4-methylphenyl)heptanediamide; RGFA-8;TC-H 106;Histone Deacetylase Inhibitor VII; RGFA-8; SCHEMBL1065609; CHEMBL3940985; DTXSID10581754; EX-A916; TC-H106; BDBM207628; HMS3648I10; BCP16854; US9265734, RGFA8; 1900AH; MFCD17010287; s6738; ZINC34997445; AKOS024458065; CCG-208665; CS-5229; TC-H 106;Pimelic Diphenylamide 106; AK222718; AS-56015; HY-19348; FT-0700415; n1-(2-aminophenyl)-n7-p-tolylheptanediamide; EC-000.2470; Pimelic Diphenylamide 106, >=98% (HPLC); SR-01000946373; SR-01000946373-1; N-(4-Methylphenyl)-N'-(2-aminophenyl)heptanediamide; N1-(2-Aminophenyl)-N7-(4-methylphenyl)heptanediamide; Q27165947; N~1~-(2-Aminophenyl)-N~7~-(4-methylphenyl)heptanediamide
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| Activity |
IC50 = 66200 nM
|
[6] | |||
| Compound Name |
2-[5-(3-Nitrophenyl)furfuryl]-1,2,3,4-tetrahydroisoquinoline-7-carbohydroximic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3338404; BDBM50027664
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| Activity |
IC50 = 71100 nM
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[7] | |||
| Compound Name |
N-(2-Aminophenyl)-7,7-di(1H-indol-3-yl)heptanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL564916; ST-3071; SCHEMBL1308188; BDBM50297448
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| Activity |
IC50 = 73000 nM
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[8] | |||
| Compound Name |
Onc(cccc=1N=C(SC=1)\\C=C\\C1=CC=CC=C1)=O
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3792392; SCHEMBL17335750; SCHEMBL17335751; BDBM50156678
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| Activity |
IC50 = 78310 nM
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[9] | |||
| Compound Name |
3-[(2E,4E)-5-(3,4-Dimethoxyphenyl)penta-2,4-dienoyl]-7-methoxychromen-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3318732; BDBM50052830
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| Activity |
IC50 = 85000 nM
|
[10] | |||
| Compound Name |
N-Hydroxy-E-3-(4''-methoxybiphenyl-4-yl)-acrylamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL561209; SCHEMBL3292536; SCHEMBL3292542; BDBM50293361; (E)-N-hydroxy-3-[4-(4-methoxyphenyl)phenyl]prop-2-enamide
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| Activity |
IC50 = 91000 nM
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[5] | |||
| Compound Name |
Chembl4215954
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Investigative | Compound Info | ||
| Synonyms |
BDBM50458581
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| Activity |
IC50 ~ 100000 nM
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[4] | |||
| Compound Name |
Chembl4206537
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Investigative | Compound Info | ||
| Synonyms |
BDBM50458585
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| Activity |
IC50 ~ 100000 nM
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[4] | |||
| Compound Name |
(2E,4E)-5-[4-[3-(1-Adamantyl)-4-methoxyphenyl]phenyl]-N-hydroxypenta-2,4-dienamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3235787; BDBM50005732
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| Activity |
IC50 ~ 100000 nM
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[5] | |||
| Compound Name |
E,E-5-(4''-Methoxybiphenyl-4-yl)-penta-2,4-dienoic acid Nhydroxyamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL538364; BDBM50293369
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| Activity |
IC50 ~ 100000 nM
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[5] | |||
| Compound Name |
Chembl4218915
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Investigative | Compound Info | ||
| Synonyms |
BDBM50458572
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| Activity |
IC50 ~ 100000 nM
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[4] | |||
| Compound Name |
Chembl4214502
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Investigative | Compound Info | ||
| Synonyms |
BDBM50458584
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
(7R)-N-Hydroxy-7-[(4-pyridin-3-ylpyrimidin-2-yl)amino]-5,6,7,8-tetrahydronaphthalene-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3338418; BDBM50027662
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| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
Chembl4209463
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Investigative | Compound Info | ||
| Synonyms |
BDBM50458570
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
N-(2-Aminophenyl)-4-[[[(4R,5S)-4,5-diphenyl-1,3-oxazolidin-2-ylidene]amino]methyl]benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3605506; BDBM50113971
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|
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| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
(E)-3-[4-[3-(1-Adamantyl)-4-hydroxyphenyl]phenyl]-N-hydroxyprop-2-enamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3235463; SCHEMBL3295457; SCHEMBL3295460; BDBM50005744; E-3-[3'-(1-adamantyl)-4'-hydroxy-biphenyl-4-yl]-N-hydroxy-acrylamide
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| Activity |
IC50 ~ 100000 nM
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[5] | |||
| Compound Name |
Chembl4202838
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Investigative | Compound Info | ||
| Synonyms |
BDBM50458579
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Appraisal of GABA and PABA as linker: design and synthesis of novel benzamide based histone deacetylase inhibitors. Eur J Med Chem. 2012 Jul;53:390-7. | ||||
| REF 2 | Potent histone deacetylase inhibitors derived from 4-(aminomethyl)-N-hydroxybenzamide with high selectivity for the HDAC6 isoform. J Med Chem. 2013 Sep 26;56(18):7201-11. | ||||
| REF 3 | Histone deacetylase inhibitors derived from 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine and related heterocycles selective for the HDAC6 isoform. Bioorg Med Chem Lett. 2014 Dec 1;24(23):5450-4. | ||||
| REF 4 | 5-Aroylindoles Act as Selective Histone Deacetylase 6 Inhibitors Ameliorating Alzheimer's Disease Phenotypes. J Med Chem. 2018 Aug 23;61(16):7087-7102. | ||||
| REF 5 | Influence of the adamantyl moiety on the activity of biphenylacrylohydroxamic acid-based HDAC inhibitors. Eur J Med Chem. 2014 May 22;79:251-9. | ||||
| REF 6 | US patent application no. 9265734B2, Compositions including 6-aminohexanoic acid derivatives as HDAC inhibitors | ||||
| REF 7 | Identification of a novel aminotetralin class of HDAC6 and HDAC8 selective inhibitors. J Med Chem. 2014 Oct 9;57(19):8026-34. | ||||
| REF 8 | Exploring bis-(indolyl)methane moiety as an alternative and innovative CAP group in the design of histone deacetylase (HDAC) inhibitors. Bioorg Med Chem Lett. 2009 May 15;19(10):2840-3. | ||||
| REF 9 | Computer-aided identification of new histone deacetylase 6 selective inhibitor with anti-sepsis activity. Eur J Med Chem. 2016 Jun 30;116:126-135. | ||||
| REF 10 | Novel inhibitors of human histone deacetylases: design, synthesis and bioactivity of 3-alkenoylcoumarines. Bioorg Med Chem Lett. 2014 Aug 15;24(16):3797-801. | ||||
| REF 11 | Potent and Selective Inhibitors of Histone Deacetylase-3 Containing Chiral Oxazoline Capping Groups and a N-(2-Aminophenyl)-benzamide Binding Unit. J Med Chem. 2015 Sep 10;58(17):6803-18. | ||||
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