Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T94880 | Target Info | |||
| Target Name | TYRO3 tyrosine kinase receptor (TYRO3) | ||||
| Synonyms |
Tyrosine-protein kinase receptor TYRO3; Tyrosine-protein kinase TIF; Tyrosine-protein kinase SKY; Tyrosine-protein kinase RSE; Tyrosine-protein kinase DTK; Tyrosine-protein kinase BYK; TIF; SKY; RSE; DTK; BYK
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| Target Type | Clinical trial Target | ||||
| Gene Name | TYRO3 | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 3 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
N-[3-[5-Amino-6-(4-hydroxypiperidine-1-carbonyl)pyrazin-2-yl]phenyl]methanesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2018007; BDBM50380776
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| Activity |
IC50 ~ 50000 nM
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[1] | |||
| Compound Name |
1-[(4-Aminocyclohexyl)methyl]-N,N-dimethyl-3-phenylpyrazolo[3,4-d]pyrimidin-6-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2036793; SCHEMBL14752556; BDBM50384601
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| Activity |
IC50 = 75000 nM
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[2] | |||
| Compound Name |
Chembl4293688
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Investigative | Compound Info | ||
| Synonyms |
BDBM50466391
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| Activity |
IC50 ~ 100000 nM
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[3] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Pyrazine-based Syk kinase inhibitors. Bioorg Med Chem Lett. 2012 Apr 15;22(8):2784-8. | ||||
| REF 2 | Discovery of Novel Small Molecule Mer Kinase Inhibitors for the Treatment of Pediatric Acute Lymphoblastic Leukemia. ACS Med Chem Lett. 2012 Feb 9;3(2):129-134. | ||||
| REF 3 | Design, synthesis, biological evaluation and cellular imaging of imidazo[4,5-b]pyridine derivatives as potent and selective TAM inhibitors. Bioorg Med Chem. 2018 Nov 1;26(20):5510-5530. | ||||
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