Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T97149 | Target Info | |||
| Target Name | Dual-specificity tyrosine-phosphorylation regulated kinase 3 (DYRK3) | ||||
| Synonyms |
Regulatory erythroid kinase; REDK; Dual specificity tyrosine-phosphorylation-regulated kinase 3
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| Target Type | Patented-recorded Target | ||||
| Gene Name | DYRK3 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 3 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
10-Chloro-11H-indolo[3,2-c]quinoline-6-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3589660; BDBM50097867
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(2S)-2-[[3-[3-(Trifluoromethyl)phenyl]imidazo[1,2-b]pyridazin-6-yl]amino]butan-1-ol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4086402; BDBM50259411
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
10-Bromo-11H-indolo[3,2-c]quinoline-6-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3589661; BDBM50097868
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | 10-iodo-11H-indolo[3,2-c]quinoline-6-carboxylic acids are selective inhibitors of DYRK1A. J Med Chem. 2015 Apr 9;58(7):3131-43. | ||||
| REF 2 | Exploration of the imidazo[1,2-b]pyridazine scaffold as a protein kinase inhibitor. Eur J Med Chem. 2017 Jan 5;125:696-709. | ||||
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