Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T98089 | Target Info | |||
| Target Name | Deoxycytidine kinase (DCK) | ||||
| Synonyms |
dCK
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| Target Type | Literature-reported Target | ||||
| Gene Name | DCK | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 1 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
5-Fluoro-2'-deoxycytidine
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Investigative | Compound Info | ||
| Synonyms |
2'-Deoxy-5-fluorocytidine; FdCyd; 5-Fluorodeoxycytidine; 5-Fluoro-2-deoxycytidine; Cytidine, 2'-deoxy-5-fluoro-; UNII-KUA4693H5W; NSC-48006; KUA4693H5W; CHEMBL1076257; MFCD00077348; Ro 5-1090; 5-Fluor-desoxycytidin; 2'-Deoxy-5-fluorcytidine; 5-Fluor-desoxycytidin [German]; NSC 48006; BRN 0619209; 5-Fluoro 2'-deoxycytidine; SCHEMBL8345; 2''-deoxy-5-fluorocytidine; 2'-deoxy-5-fluoro-Cytidine; MLS006010723; Cytidine,2'-deoxy-5-fluoro-; DTXSID2030437; CTK8A9064; BCP18422; 0860AA; ANW-14931; BDBM50311540; s2477; ZB1480; ZINC17311164; 5-Deoxy-5-fluorocytidine (5-DFCR); AKOS015853117; AKOS016002166; DB12957; SB17172; NCGC00346830-01; AC-32303; AS-74677; SC-54218; SMR004701686; CS-0064397; D3642; 335D384; 5-Fluoro-2'-deoxycytidine, >=98% (HPLC), powder; Q27282447
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| Activity |
IC50 = 120000 nM
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[1] | |||
| Non Binders of This Target (in total, 3 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Zalcitabine
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Approved | Compound Info | ||
| Synonyms |
zalcitabine; Dideoxycytidine; 7481-89-2; 2',3'-DIDEOXYCYTIDINE; ddCyd; HIVID; ddC; Cytidine, 2',3'-dideoxy-; Zalcitibine; 4-Amino-1-((2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one; 2,3-dideoxycytidine; NSC 606170; UNII-6L3XT8CB3I; CCRIS 692; HSDB 7156; C9H13N3O3; Ro-24-2027/000; Ro 24-2027/000; CHEMBL853; BRN 0654956; 6L3XT8CB3I; CHEBI:10101; 1-(2,3-Dideoxy-beta-D-ribofuranosyl)cytosine; WREGKURFCTUGRC-POYBYMJQSA-N; 4-amino-1-[(2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2(1H)-one; MFCD00012188; DdC; DdCyd; D 5782; DDC (DDC); DdC & Interferon alpha; DdC & sCD4; DdC (Antiviral); Hivid (TN); Hivid(TM); Interferon AD + ddC; KS-1130; SRI-7707; Beta-D-DDC; DS-4152 & ddC; DdC & GM-CSF; DdC & IFN-alpha; DdC & NP (from PHCA or HSA); PC-SOD & ddC; Zalcitabine [USAN:INN:BAN]; Hivid, Dideoxycytidine, NSC 606170, Zalcitabine; Zalcitabine (JAN/USP/INN); Beta-D-2',3'-Dideoxycytidine; Cytidine, 2',3'-dideoxy & Interferon alpha; Sulfated polysaccharide-peptidoglycan DS-4152 & 2',3'-Dideoxycytidine; Cytidine, 2',3'-dideoxy-& Colony-stimulating factor; Beta-D-2',3'-Dideoxycytidine & Granulocyte-macrophage colony-stimulating factor; Lecithinized superoxide dismutase & beta-D-2',3'-Dideoxycytidine; 2',3'-Dideoxycytidine & Interferon-alpha; 2',3'-Dideoxycytidine & Nanoparticles (from human serum albumin or polyhexylcyanoacrylate); 2',3'-Dideoxycytidine & sCD4(soluble recombinant protein); 3'-Azido-3'-deoxythymidine/2',3'-Dideoxycytidine; 4-amino-1-[(2R,5S)-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one; DdC
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| Activity |
Ki = 360000 nM
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[2] | |||
| Compound Name |
4-(1-Benzothiophen-2-yl)-6-[4-(2-oxo-2-pyrrolidin-1-ylethyl)piperazin-1-yl]pyrimidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1081559; BDBM50311539; Q27458265; 2-(4-(6-(benzo[b]thiophen-2-yl)pyrimidin-4-yl)piperazin-1-yl)-1-(pyrrolidin-1-yl)ethanone; 2-{4-[6-(1-benzothiophen-2-yl)pyrimidin-4-yl]piperazin-1-yl}-1-(pyrrolidin-1-yl)ethanone
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| Activity |
IC50 = 510000 nM
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[1] | |||
| Compound Name |
2',3'-Didehydro-2',3'-dideoxycytidine
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Investigative | Compound Info | ||
| Synonyms |
2',3'-Dideoxycytidinene; 2',3'-Dideoxy-2',3'-didehydrocytidine; UNII-CI9X00489L; 4-amino-1-[(2R,5S)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]pyrimidin-2-one; CHEMBL2115278; CI9X00489L; ddeCyd; Cytidine, 2,3'-didehydro-2',3'-dideoxy-; SCHEMBL5821; 2',3'-Dideoxydidehydrocytidine; DTXSID30225784; BDBM50421873; ZINC17175690; 2'3'-dideoxy-2',3'-didehydrocytidine; Cytidine, 2',3'-didehydro-2',3'-dideoxy-; Q27275480; 4-Amino-1-(5-hydroxymethyl-2,5-dihydro-furan-2-yl)-1H-pyrimidin-2-one; 4-Amino-1-((2R,5S)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl)pyrimidin-2(1H)-one
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| Activity |
Ki = 1100000 nM
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[2] | |||
| References | Top | ||||
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| REF 1 | 5-Fluorocytosine derivatives as inhibitors of deoxycytidine kinase. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6780-3. | ||||
| REF 2 | Synthesis and in vitro evaluation of some modified 4-thiopyrimidine nucleosides for prevention or reversal of AIDS-associated neurological disorders. J Med Chem. 1990 Jan;33(1):258-63. | ||||
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