Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T99089 | Target Info | |||
| Target Name | Serine/threonine-protein kinase B-raf (BRAF) | ||||
| Synonyms |
V-Raf murine sarcoma viral oncogene homolog B1; RAFB1; Proto-oncogene B-Raf; P94; BRAF1; BRAF(V599E); BRAF serine/threonine kinase; B-raf protein; B-Raf
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| Target Type | Successful Target | ||||
| Gene Name | BRAF | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 127 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Imatinib
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|
Approved | Compound Info | ||
| Synonyms |
Cgp 57148; Glamox; Glamox (TN); Gleevec (TN); Glivec (TN); Imatinib (INN); Imatinib (STI571); Imatinib Methansulfonate; Imatinib [INN:BAN]; 112GI019; 152459-95-5; BKJ8M8G5HI; CCRIS 9076; CGP-57148; CHEMBL941; Imatinib free base; STI; UNII-BKJ8M8G5HI
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Niclosamide
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Approved | Compound Info | ||
| Synonyms |
niclosamide; 50-65-7; Niclocide; 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide; Tredemine; Bayluscid; Phenasal; Yomesan; Fenasal; Dichlosale; Helmiantin; Sagimid; Iomezan; Devermine; Atenase; Vermitid; Radeverm; Mansonil; Iomesan; Devermin; Cestocid; Sulqui; Lintex; Nasemo; Mato; Fedal-Telmin; Bayer 73; Radewerm; Zestocarp; Bayer 2353; 2',5-Dichloro-4'-nitrosalicylanilide; Chemagro 2353; BAY 2353; Benzamide, 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxy-; 5-Chloro-2'-chloro-4'-nitrosalicylanilide; nicolsamide; HL 2447; Niclosamidum [I
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Chembl4208998
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50451034
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
3-[4-[[4-Chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenyl]-N-(1-phenylethyl)benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3262871; BDBM50011572
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
3-(N-Methyl-1H-indol-3-yl)-4-(3,4,5-trimethoxyphenyl)-1,5-dihydro-2H-pyrrole-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL509435; SCHEMBL13961125; BDBM50243980; 4-(1-methylindol-3-yl)-3-(3,4,5-trimethoxyphenyl)-1,2-dihydropyrrol-5-one
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| Activity |
IC50 = 50000 nM
|
[5] | |||
| Compound Name |
7-Benzyl-3-methyl-8-[(2Z)-2-[(3-nitrophenyl)methylidene]hydrazinyl]purine-2,6-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL459936; ZINC5220219
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|
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
4-[4-[(E)-3-(4-Fluorophenyl)-3-oxoprop-1-enyl]phenoxy]-N-methylpyridine-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3945365; BDBM50199451
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| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
Chembl4202658
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Investigative | Compound Info | ||
| Synonyms |
BDBM50451033
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
1-(3-Fluorophenyl)-3-[3-[(2-oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]urea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL591264
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| Activity |
IC50 = 50200 nM
|
[8] | |||
| Compound Name |
6-(3-Fluorophenoxy)-N-(3,4,5-trimethoxyphenyl)pyrazin-2-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL520623; SCHEMBL1122943; BDBM25601; 2,6-Disubstituted Pyrazine, 64; 2-(3,4,5-Trimethoxyphenylamino)-6-(3-fluorophenyl-oxy)-pyrazine
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| Activity |
IC50 = 56000 nM
|
[9] | |||
| Compound Name |
N-[3-[(2-Oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]-3-(trifluoromethyl)benzenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL598624
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|
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| Activity |
IC50 = 57000 nM
|
[8] | |||
| Compound Name |
7-Benzyl-8-(3,5-dimethyl-1H-pyrazol-1-yl)-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione
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|
Investigative | Compound Info | ||
| Synonyms |
F2475-0035; purine-2,6-dione, 27; CHEMBL518187; BDBM25384; STK929065; ZINC12231347; AKOS005658847; CCG-290433; MCULE-4391692236; Z906123350
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| Activity |
IC50 = 57710 nM
|
[6] | |||
| Compound Name |
4-Nitrobenzaldehyde (7-benzyl-3-methyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-YL)hydrazone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL518163; ZINC6444794
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| Activity |
IC50 = 57890 nM
|
[6] | |||
| Compound Name |
CID 46197875
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1089691; SCHEMBL4460266; BDBM50482005
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| Activity |
IC50 = 58000 nM
|
[10] | |||
| Compound Name |
2-(4-Methoxyphenyloxyethylamino)-6-(3-acetamidophenyl)-pyrazine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL198400; BDBM50180349
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|
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| Activity |
IC50 = 58000 nM
|
[11] | |||
| Compound Name |
CID 44186294
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL522724; SCHEMBL4469404; BDBM50480116
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|
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| Activity |
IC50 = 59000 nM
|
[12] | |||
| Compound Name |
N-(9H-Pyrido[3,4-b]indol-6-ylsulfonyl)acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2047073; BDBM50387082
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| Activity |
IC50 = 59110 nM
|
[13] | |||
| Compound Name |
5-Amino-4-(3,4-dichlorophenyl)thiopheno[2,3-d]pyrimidine-6-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1934498; SCHEMBL4908483; BDBM50360793; 5-amino-4-(3,4-dichlorophenyl)thieno[2,3-d]pyrimidine-6-carboxamide
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| Activity |
IC50 ~ 60000 nM
|
[14] | |||
| Compound Name |
5-Amino-1-phenyl-3-pyridin-4-ylpyrazole-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2011301; SCHEMBL14833703; BDBM50379215
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|
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| Activity |
IC50 = 64000 nM
|
[15] | |||
| Compound Name |
3-Chloro-2-fluoro-N-[3-[(2-oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]-5-(trifluoromethyl)benzenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL599441
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| Activity |
IC50 = 65000 nM
|
[8] | |||
| Compound Name |
2-Phenoxyethylamino-6-(3-acetamidophenyl)pyrazine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL200964; BDBM50180340
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| Activity |
IC50 = 65000 nM
|
[11] | |||
| Compound Name |
N-[3-[(2-Oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]-1-benzothiophene-5-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL597618
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|
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| Activity |
IC50 = 66000 nM
|
[8] | |||
| Compound Name |
4-Chloro-N-[3-[(2-oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]-3-(trifluoromethyl)benzenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL596981
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|
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| Activity |
IC50 = 66000 nM
|
[8] | |||
| Compound Name |
4-Chloro-N-[3-[(2-oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]benzenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL592616
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|
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| Activity |
IC50 = 68000 nM
|
[8] | |||
| Compound Name |
CID 44133365
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1214613; SCHEMBL3767302; BDBM50482442
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|
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| Activity |
IC50 = 69000 nM
|
[16] | |||
| Compound Name |
5-({6-[(3,4,5-Trimethoxyphenyl)amino]pyrazin-2-yl}oxy)-2,3-dihydro-1H-inden-1-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL521305; SCHEMBL1122222; BDBM25597; 2,6-Disubstituted Pyrazine, 60; 2-(3,4,5-Trimethoxyphenylamino)-6-(indanone-5-oxy)-pyrazine; 5-[6-(3,4,5-trimethoxyanilino)pyrazin-2-yl]oxy-2,3-dihydroinden-1-one
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|
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| Activity |
IC50 = 70000 nM
|
[9] | |||
| Compound Name |
1-[2-(4-Chlorophenyl)-5-methylpyrazol-3-yl]-3-[4-[(2-oxo-1,3-dihydroimidazo[4,5-b]pyridin-7-yl)oxy]phenyl]urea
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1092465; SCHEMBL4461769; BDBM50482020
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|
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| Activity |
IC50 = 70000 nM
|
[10] | |||
| Compound Name |
2-(2-Methoxyphenylamino)-6-(3-acetamidophenyl)pyrazine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL201023; SCHEMBL1121970; BDBM50180361; N-[3-[6-(2-methoxyanilino)pyrazin-2-yl]phenyl]acetamide
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| Activity |
IC50 = 74000 nM
|
[11] | |||
| Compound Name |
N-(4-Chlorophenyl)-2-phenylimidazo[1,2-a]pyrazin-3-amine
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2913681; CHEMBL1668903
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| Activity |
IC50 = 76000 nM
|
[17] | |||
| Compound Name |
6-({6-[(3,4,5-Trimethoxyphenyl)amino]pyrazin-2-yl}oxy)-1,2,3,4-tetrahydronaphthalen-1-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL483916; SCHEMBL12857511; BDBM25595; 2,6-Disubstituted Pyrazine, 58
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|
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| Activity |
IC50 = 76000 nM
|
[9] | |||
| Compound Name |
2,5-Dimethyl-N-[3-[(2-oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]pyrazole-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL598652
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| Activity |
IC50 = 79000 nM
|
[8] | |||
| Compound Name |
N-[3-[(2-Oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]-2-(trifluoromethoxy)benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL598428
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| Activity |
IC50 = 79000 nM
|
[8] | |||
| Compound Name |
2-(6-Amino-9H-purine-9-yl)-1-(1H-indole-3-yl)ethanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL521155; BDBM50268223
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| Activity |
IC50 = 82000 nM
|
[18] | |||
| Compound Name |
2-[4-(Trifluoromethoxy)phenylamino]-6-(3-acetamidophenyl)-pyrazine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL378600; SCHEMBL1122219; BDBM50180355; N-[3-[6-[4-(trifluoromethoxy)anilino]pyrazin-2-yl]phenyl]acetamide; N-(3-(6-(4-(trifluoromethoxy)phenylamino)pyrazin-2-yl)phenyl)acetamide
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| Activity |
IC50 = 84000 nM
|
[11] | |||
| Compound Name |
(NE)-N-[6-[6-(3,4,5-trimethoxyanilino)pyrazin-2-yl]oxy-2,3-dihydroinden-1-ylidene]hydroxylamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL520632
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| Activity |
IC50 = 86000 nM
|
[9] | |||
| Compound Name |
N-[3-[(2-Oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]-1-phenylmethanesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL598834
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| Activity |
IC50 = 87000 nM
|
[8] | |||
| Compound Name |
6-(2,2-Dimethoxyethylsulfamoyl)-9H-pyrido[3,4-b]indole-1-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2047061; BDBM50387071
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| Activity |
IC50 = 91550 nM
|
[13] | |||
| Compound Name |
N-[3-[(2-Oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]-2-phenylpyrazole-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL598856
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| Activity |
IC50 = 92000 nM
|
[8] | |||
| Compound Name |
(NE)-N-[6-[6-(3,4,5-trimethoxyanilino)pyrazin-2-yl]oxy-3,4-dihydro-2H-naphthalen-1-ylidene]hydroxylamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL483297; SCHEMBL12857760
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| Activity |
IC50 = 92000 nM
|
[9] | |||
| Compound Name |
2-Chloro-N-[3-[(2-oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]pyridine-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL597619
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| Activity |
IC50 = 93000 nM
|
[8] | |||
| Compound Name |
N-[3-[(2-Oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]-3-(trifluoromethoxy)benzenesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL603252
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| Activity |
IC50 = 94000 nM
|
[8] | |||
| Compound Name |
N-[3-[(2-Oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]-2-phenylethanesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL598835
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| Activity |
IC50 = 94000 nM
|
[8] | |||
| Compound Name |
Chembl4285067
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Investigative | Compound Info | ||
| Synonyms |
BDBM50468566
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| Activity |
IC50 = 95900 nM
|
[19] | |||
| Compound Name |
2-(3-Chloro-4-fluorobenzylamino)-6-(3-acetamidophenyl)-pyrazine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL274738; BDBM50180347
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| Activity |
IC50 = 99000 nM
|
[11] | |||
| Compound Name |
1-[1-(2-Methoxyphenyl)-2,5-dioxopyrrolidin-3-yl]piperidine-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
Cambridge id 5613613; CHEMBL459714; STK002031; AKOS000585201; AKOS016301413; MCULE-2546335507; ST072722; AB00090524-01; SR-01000516038; SR-01000516038-1; 1-[1-(2-methoxyphenyl)-2,5-dioxoazolidin-3-yl]piperidine-4-carboxamide
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
1-(Thiophen-2-yl)-2-(4H-[1,2,4]triazolo[1,5-a]benzimidazol-4-yl)ethanone
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Investigative | Compound Info | ||
| Synonyms |
Oprea1_848448; CHEMBL502945; ZINC268668; CCG-20760; STK028159; AKOS000659816; MCULE-1017651970; EU-0078956; SR-01000497654; SR-01000497654-1
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
N-(2,6-Dimethylphenyl)-2-{[4-methyl-5-(4-morpholinylmethyl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL462280; DTXSID10966143; STK283984; ZINC19799015; AKOS000420534; MCULE-5653301448; AH-487/42362399; SR-01000367708; SR-01000367708-1
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
N-[3-[(2-Oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]-3,4-dihydro-2H-1,5-benzodioxepine-6-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL597617
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| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
N-[3-[(2-Oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL591257
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| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
Pyridoimidazolone, 5g
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL476067; SCHEMBL4458189; BDBM29707; 1-[4-[(2-oxo-1,3-dihydroimidazo[4,5-b]pyridin-7-yl)oxy]phenyl]-3-[4-(trifluoromethyl)phenyl]urea
Click to Show/Hide
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| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
N-[4-[(2-Oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]-3-(trifluoromethyl)benzenesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL598625
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| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
N-[3-[(2-Oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]-1,3-dihydro-2,1,3-benzothiadiazole-5-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL604919
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| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
2-(Phenyl-N-methylamino)-6-(3-acetamidophenyl)pyrazine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL199805; BDBM50180346
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| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
2-(3,4,5-Trimethoxyphenylamino)-3-acetamido-6-(3-acetamidophenyl)pyrazine
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Investigative | Compound Info | ||
| Synonyms |
Acetamidopyrazine, 16; CHEMBL484917; SCHEMBL1122073; BDBM25571; N-[3-[5-acetamido-6-(3,4,5-trimethoxyanilino)pyrazin-2-yl]phenyl]acetamide; N-[5-(3-acetamidophenyl)-3-[(3,4,5-trimethoxyphenyl)amino]pyrazin-2-yl]acetamide
Click to Show/Hide
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| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
1-(2-Fluoro-5-(trifluoromethyl)phenyl)-3-(3-(2-oxo-1,2-dihydropyrido[2,3-b]pyrazin-8-yloxy)phenyl)urea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1214504; SCHEMBL2935792; BDBM50482470; 1-[2-fluoro-5-(trifluoromethyl)phenyl]-3-[3-[(2-oxo-1H-pyrido[2,3-b]pyrazin-8-yl)oxy]phenyl]urea
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
5-Pyridin-4-yl-2-(2,4,6-trichlorophenyl)pyrazol-3-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2011303; SCHEMBL14839420; BDBM50379219
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| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
1-{2-[5-(2-Furyl)-3-(2-thienyl)-4,5-dihydro-1H-pyrazol-1-yl]-2-oxoethyl}-4-methylpiperazine
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Investigative | Compound Info | ||
| Synonyms |
F3172-0005; AO-476/43250206; MLS000701182; CHEMBL459715; HMS2519P23; AKOS001470406; MCULE-4805935868; SMR000229621; Z46161037
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
4-[(4-Methylpiperazin-1-yl)methyl]-N-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1213923; BDBM50323916; 4-((4-methylpiperazin-1-yl)methyl)-N-(4-(2-morpholinoethoxy)naphthalen-1-yl)benzamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
N-[4-[(2-Oxo-1,3-dihydroimidazo[4,5-b]pyridin-7-yl)oxy]naphthalen-1-yl]-2-[3-(trifluoromethyl)phenyl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL521557; BDBM50480128
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
2-Benzyl-5-tert-butyl-N-[3-[(2-oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]pyrazole-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL603253
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
5-[4-[2-[4-[2-(Dimethylamino)ethoxy]phenyl]-5-pyridin-4-yl-1H-imidazol-4-yl]phenyl]-1H-pyrazole-4-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1253868; BDBM50482736
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(2-oxo-1,2-dihydro pyrido[2,3-b]pyrazin-8-yloxy)phenyl)urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1214137; SCHEMBL3755881; BDBM50482503; 1-[4-chloro-3-(trifluoromethyl)phenyl]-3-[4-[(2-oxo-1H-pyrido[2,3-b]pyrazin-8-yl)oxy]phenyl]urea
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
Pyridoimidazolone, 29c
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL489649; SCHEMBL4468466; BDBM29739; 4-chloro-N-[4-[(2-oxo-1,3-dihydroimidazo[4,5-b]pyridin-7-yl)oxy]phenyl]benzenesulfonamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
N-Methyl-4-(4-(4-((4-methylpiperazin-1-yl)methyl)benzamido)phenoxy)picolinamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1213922; BDBM50323915
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-(3-Phenylpropylamino)-6-(3-acetamidophenyl)pyrazine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL200130; BDBM50180338
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
Pyridoimidazolone, 5b
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL476859; SCHEMBL4458209; BDBM29702; 1-(4-(2,3-dihydro-2-oxo-1H-imidazo[4,5-b]pyridin-7-yl-oxy)phenyl)-3-phenyl-urea; 1-[4-[(2-oxo-1,3-dihydroimidazo[4,5-b]pyridin-7-yl)oxy]phenyl]-3-phenylurea
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
N-[2-Methyl-3-[(2-oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]-3-(trifluoromethoxy)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL599041
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
7-[2-[4-[2-(Dimethylamino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-imidazole-4-yl]quinoline-2(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2336803; BDBM50490677
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
N-[4-[(2-Oxo-1,3-dihydroimidazo[4,5-b]pyridin-7-yl)oxy]naphthalen-1-yl]-2-[3-(trifluoromethoxy)phenyl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL496409; BDBM50480118
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
Ethyl 5-amino-3-pyridin-4-yl-1-(2,4,6-trichlorophenyl)pyrazole-4-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2011300; SCHEMBL14833707; BDBM50379221; Ethyl 5-amino-3-(pyridin-4-yl)-1-(2,4,6-trichlorophenyl)-1H-pyrazole-4-carb-oxylate
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
1-Methyl-4-({8-[(4-methyl-1-piperazinyl)methyl]-1,2,3,5,6,7-hexahydro-s-indacen-4-yl}methyl)piperazine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Oprea1_270401; AE-641/30115011; CHEMBL459515; ZINC19802245; AKOS005065652
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
(4E)-4-[2,3-Dihydro-1,4-benzodioxin-6-yl(hydroxy)methylidene]-1-(3-imidazol-1-ylpropyl)-5-(5-methylfuran-3-yl)pyrrolidine-2,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL516807
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
N-[3-[(2-Oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]-4-(trifluoromethyl)benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL596984
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
Pyridoimidazolone, 5f
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL476066; SCHEMBL4468358; BDBM29706; 1-[4-[(2-oxo-1,3-dihydroimidazo[4,5-b]pyridin-7-yl)oxy]phenyl]-3-[2-(trifluoromethyl)phenyl]urea
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
N-[4-Methyl-3-[(2-oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]-3-(trifluoromethoxy)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL596788
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
Pyridoimidazolone, 29a
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL489648; SCHEMBL4462665; BDBM29737
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
Pyridoimidazolone, 27f
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL489842; SCHEMBL4475460; BDBM29731; 3-fluoro-5-morpholin-4-yl-N-[4-[(2-oxo-1,3-dihydroimidazo[4,5-b]pyridin-7-yl)oxy]phenyl]benzamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
2-Amino-4-[4-[(3,5-dimethyl-4-nitropyrazol-1-yl)methyl]-3-methoxyphenyl]-5-oxo-4,6,7,8-tetrahydrochromene-3-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL462279
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
N-[4-[(2-Oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]-4-(trifluoromethoxy)benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL597399
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
Pyridoimidazolone, 5c
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL477062; SCHEMBL4460240; BDBM29703; 1-(4-chlorophenyl)-3-[4-[(2-oxo-1,3-dihydroimidazo[4,5-b]pyridin-7-yl)oxy]phenyl]urea
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
N-Methyl-4-(4-(3-(4-((4-methylpiperazin-1-yl)methyl)phenyl)ureido)phenoxy)picolinamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1213975; BDBM50323920
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
5-Amino-3-pyridin-4-yl-1-(2,4,6-trichlorophenyl)pyrazole-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2011299; SCHEMBL14833763; BDBM50379222
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
1-(3,4-Difluorophenyl)-3-[4-[(2-oxo-1,3-dihydroimidazo[4,5-b]pyridin-7-yl)oxy]naphthalen-1-yl]urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL498113; BDBM50480120
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
N-(2,4-Dimethoxyphenyl)-5-(3-methoxyphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL461621; STK339127; AKOS000557491; AKOS022068323; MCULE-2364531860; ST50267439
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
3-(4-Benzylpiperazin-1-yl)-1-(3-methoxyphenyl)pyrrolidine-2,5-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
3-(4-benzyl-1-piperazinyl)-1-(3-methoxyphenyl)-2,5-pyrrolidinedione; AJ-292/41685725; CHEMBL462046; STK130648; AKOS002224854; AKOS016302100; MCULE-1549723756; ST50106205; 1-(3-methoxyphenyl)-3-[4-benzylpiperazinyl]azolidine-2,5-dione; 3-(4-benzylpiperazino)-1-(3-methoxyphenyl)dihydro-1H-pyrrole-2,5-dione; Pyrrolidine-2,5-dione, 3-(4-benzylpiperazin-1-yl)-1-(3-methoxyphenyl)-
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
1-[2-Methyl-4-(2-morpholin-4-ylethyl)-4H-pyrazolo[1,5-a]benzimidazol-3-yl]ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CBKinase1_000641; CBKinase1_013041; AE-848/33346018; CHEMBL516808; ZINC19770522; AKOS000659468; MCULE-5276209275; BRD-K61271893-003-01-2
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
1-[3-(5-Methylfuran-2-yl)-5-phenyl-3,4-dihydropyrazol-2-yl]-2-morpholin-4-ylethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL462071
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
2-[4-(4-Fluorophenyl)piperazin-1-yl]-N-[(E)-(4-hydroxy-3-methoxyphenyl)methylideneamino]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL459736
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
3-Bromo-N-[3-[(2-oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL603185
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[8] | |||
| Compound Name |
N-[3-[(2-Oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]-3-pyrrolidin-1-ylbenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL599048
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
1-Benzyl-5-chloro-2-[(4-ethylpiperazin-1-yl)methyl]benzimidazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL516655
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
N-[4-[(2-Oxo-1,3-dihydroimidazo[4,5-b]pyridin-7-yl)oxy]phenyl]-3-(trifluoromethoxy)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL489841
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
2-(3,4,5-Trimethoxyphenylamino)-6-(naphthalen-2-yloxy)pyrazine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL520330; SCHEMBL1122654; BDBM25581; 2,6-Disubstituted Pyrazine, 26a; 6-(naphthalen-2-yloxy)-N-(3,4,5-trimethoxyphenyl)pyrazin-2-amine; 6-naphthalen-2-yloxy-N-(3,4,5-trimethoxyphenyl)pyrazin-2-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
N-[3-[(2-Oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]-2,3-dihydro-1,4-benzodioxine-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL598019
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
1,3-Bis[(4-methoxyphenyl)methyl]-2-(6-methylpyridin-2-yl)-1,3-diazinane
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Maybridge2_000704; Oprea1_583790; CHEMBL460344; HMS1304P22; CCG-54647; ZINC19324521; AKOS000599700; MCULE-9702046308; SR-01000534662; SR-01000534662-1; SR-01000534662-2
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
Pyridoimidazolone, 28c
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL522582; SCHEMBL4461778; BDBM29734; 2-(3,5-difluorophenyl)-N-[4-[(2-oxo-1,3-dihydroimidazo[4,5-b]pyridin-7-yl)oxy]phenyl]acetamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
N-Phenyl-1H-pyrrolo[2,3-b]pyridin-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
UNII-B1XYZ89TUA; B1XYZ89TUA; CHEMBL1231605; N-Phenyl-1H-pyrrolo(2,3-b)pyridin-3-amine; 1H-Pyrrolo[2,3-b]pyridin-3-amine,N-phenyl-; SCHEMBL413177; BDBM50172099; DB07524; 1H-Pyrrolo(2,3-b)pyridin-3-amine, N-phenyl-; Q27096743
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
N-(3-(6-(2,2,3,3-Tetrafluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-ylamino)pyrazin-2-yl)phenyl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL199605; BDBM50180343
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
N-[4-Methoxy-3-[(2-oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]-3-(trifluoromethoxy)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL589802
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
3-Imidazol-1-yl-N-[3-[(2-oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL599661
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
6-[2-[4-[2-(Dimethylamino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-imidazole-4-yl]quinoline-2(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2336804; BDBM50490686
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
3-Fluoro-5-morpholin-4-yl-N-[4-[(2-oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL591263
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
N-(1-Morpholin-4-yl-2-oxo-2-phenylethyl)thiophene-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SMR000024697; N-[1-(morpholin-4-yl)-2-oxo-2-phenylethyl]thiophene-2-carboxamide; MLS000090079; MLS002585188; CHEMBL509283; HMS2479B05; STK027756; AKOS001665972; AKOS016289623; MCULE-6835055409; NCGC00044309-02; SR-01000492929; SR-01000492929-1; Z57215140
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
4-Chloro-N-[4-[(2-oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]-3-(trifluoromethyl)benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL599439
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
2-(2-Pyridylmethylamino)-6-(3-acetamidophenyl)pyrazine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL433992; BDBM50180348
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
4-[3-[[3-(Trifluoromethoxy)phenyl]methyl]phenoxy]-1,3-dihydrobenzimidazol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL603674
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
N-[2-Methyl-5-[(2-oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]-3-(trifluoromethoxy)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL599861
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
7-[2-[4-[2-(Dimethylamino)ethoxy]phenyl]-5-pyridin-4-yl-1H-imidazol-4-yl]-2,4,4a,5-tetrahydroindeno[1,2-c]pyridazin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1254044; BDBM50482734
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[21] | |||
| Compound Name |
3-(Dimethylamino)-N-[3-[(2-oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL598836
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
2-(3,4,5-Trimethoxybenzylamino)-6-(3-acetamidophenyl)pyrazine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL199892; BDBM50180336
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
N-[4-[(2-Oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL591258
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
N-[3-[(2-Oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]-1-phenyl-5-(trifluoromethyl)pyrazole-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL597388
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
1-(4-Amino-1,2,5-oxadiazol-3-yl)-5-[(diethylamino)methyl]-N'-(2-furylmethylene)-1H-1,2,3-triazole-4-carbohydrazide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
MLS001240071; SMR000673232; CHEMBL459500; STK673322; AKOS001716990; MCULE-3900986540; AG-205/36957103; SR-01000090024; SR-01000090024-1
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
Chembl4276946
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
GTPL9965; compound 3a [Pipionne et al, 2018]; 1-[5-amino-4-(3,4-dichlorophenyl)-3-methyl-1H-pyrazol-1-yl]ethan-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[24] | |||
| Compound Name |
1-[4-Chloro-3-(trifluoromethyl)phenyl]-3-[2-methoxy-4-[(2-oxo-1,3-dihydroimidazo[4,5-b]pyridin-7-yl)oxy]phenyl]urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL523229; BDBM50480119
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
Pyridoimidazolone, 29e
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL485300; SCHEMBL4467723; BDBM29741; 4-fluoro-N-[4-[(2-oxo-1,3-dihydroimidazo[4,5-b]pyridin-7-yl)oxy]phenyl]benzenesulfonamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
Pyridoimidazolone, 27a
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL489229; SCHEMBL4476135; BDBM29726; N-[4-[(2-oxo-1,3-dihydroimidazo[4,5-b]pyridin-7-yl)oxy]phenyl]benzamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
N-[2,4-Dichloro-5-[(2-oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]-3-(trifluoromethoxy)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL591492
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
3-[(2,5-Dimethoxyphenyl)(hydroxy)methyl]-4-(morpholin-4-ylmethyl)-1-benzofuran-5-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SMR000036355; MLS000077820; Cambridge id 5921350; Oprea1_406717; MLS002582476; CHEMBL516494; HMS2447G23; STK854031; AKOS005630762; MCULE-6354158620; SR-01000001973; SR-01000001973-2
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
2-(3-Chloro-4-fluorophenylamino)-6-(3-acetamidophenyl)-pyrazine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL198348; SCHEMBL1122334; BDBM50180364; N-[3-[6-(3-chloro-4-fluoroanilino)pyrazin-2-yl]phenyl]acetamide; N-(3-(6-(3-chloro-4-fluorophenylamino)pyrazin-2-yl)phenyl)acetamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
5-(1H-Indol-3-yl)-3-(3,4,5-trimethoxyphenyl)-1H-pyrazin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3358966
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
5-Amino-3-pyridin-4-yl-1-(2,4,6-trichlorophenyl)pyrazole-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2011302; SCHEMBL14833637; BDBM50379220; 5-Amino-3-(pyridine-4-yl)-1-(2,4,6-trichlorophenyl)-1H-pyrazole-4-carboxylic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
Pyridoimidazolone, 29d
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL485299; SCHEMBL4473421; BDBM29740
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
N-[2-Chloro-5-[(2-oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]-3-(trifluoromethoxy)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL606189
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
CID 44186297
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL524812; SCHEMBL4461589; BDBM50480117
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
Chembl4288433
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50468564
Click to Show/Hide
|
||||
| Activity |
IC50 = 124000 nM
|
[19] | |||
| Compound Name |
Chembl4291854
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50468568
Click to Show/Hide
|
||||
| Activity |
IC50 = 156000 nM
|
[19] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 5 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Chembl4283993
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50468569
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[19] | |||
| Compound Name |
Chembl4276699
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50468563
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[19] | |||
| Compound Name |
Chembl4282640
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50468560
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[19] | |||
| Compound Name |
Chembl4280550
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50468561
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[19] | |||
| Compound Name |
Chembl4277125
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50468565
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[19] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | The design, synthesis, and evaluation of 8 hybrid DFG-out allosteric kinase inhibitors: a structural analysis of the binding interactions of Gleevec, Nexavar, and BIRB-796. Bioorg Med Chem. 2010 Aug 1;18(15):5738-48. | ||||
| REF 2 | Identification of Niclosamide as a New Small-Molecule Inhibitor of the STAT3 Signaling Pathway. ACS Med Chem Lett. 2010 Sep 7;1(9):454-9. | ||||
| REF 3 | Design, synthesis and antitumor activity of Novel Sorafenib derivatives bearing pyrazole scaffold. Bioorg Med Chem. 2017 Oct 15;25(20):5754-5763. | ||||
| REF 4 | Design, synthesis and evaluation of novel diaryl urea derivatives as potential antitumor agents. Eur J Med Chem. 2014 Apr 22;77:351-60. | ||||
| REF 5 | Design, synthesis, and biological evaluation of novel 3-aryl-4-(1H-indole-3yl)-1,5-dihydro-2H-pyrrole-2-ones as vascular endothelial growth factor receptor (VEGF-R) inhibitors. J Med Chem. 2008 Jul 10;51(13):3814-24. | ||||
| REF 6 | Identification of BRAF inhibitors through in silico screening. J Med Chem. 2008 Oct 9;51(19):6121-6127. | ||||
| REF 7 | Design, synthesis and activity of novel sorafenib analogues bearing chalcone unit. Bioorg Med Chem Lett. 2016 Nov 15;26(22):5450-5454. | ||||
| REF 8 | BRAF inhibitors based on an imidazo[4,5]pyridin-2-one scaffold and a meta substituted middle ring. J Med Chem. 2010 Mar 11;53(5):1964-78. | ||||
| REF 9 | Novel inhibitors of the v-raf murine sarcoma viral oncogene homologue B1 (BRAF) based on a 2,6-disubstituted pyrazine scaffold. J Med Chem. 2008 Jun 12;51(11):3261-74. | ||||
| REF 10 | Development of novel, highly potent inhibitors of V-RAF murine sarcoma viral oncogene homologue B1 (BRAF): increasing cellular potency through optimization of a distal heteroaromatic group. J Med Chem. 2010 Apr 8;53(7):2741-56. | ||||
| REF 11 | Novel inhibitors of B-RAF based on a disubstituted pyrazine scaffold. Generation of a nanomolar lead. J Med Chem. 2006 Jan 12;49(1):407-16. | ||||
| REF 12 | Novel potent BRAF inhibitors: toward 1 nM compounds through optimization of the central phenyl ring. J Med Chem. 2009 Jul 9;52(13):3881-91. | ||||
| REF 13 | Design, synthesis and biological evaluation of -carboline derivatives as novel inhibitors targeting B-Raf kinase. Bioorg Med Chem Lett. 2012 Jul 15;22(14):4783-6. | ||||
| REF 14 | Discovery and optimization of thieno[2,3-d]pyrimidines as B-Raf inhibitors. Bioorg Med Chem Lett. 2012 Jan 1;22(1):747-52. | ||||
| REF 15 | US patent application no. 9416123B2, Kinase modulators for the treatment of cancer | ||||
| REF 16 | Novel hinge binder improves activity and pharmacokinetic properties of BRAF inhibitors. J Med Chem. 2010 Aug 12;53(15):5639-55. | ||||
| REF 17 | The discovery of furo[2,3-c]pyridine-based indanone oximes as potent and selective B-Raf inhibitors. Bioorg Med Chem Lett. 2011 Feb 15;21(4):1248-52. | ||||
| REF 18 | Design, synthesis and characterization of N9/N7-substituted 6-aminopurines as VEGF-R and EGF-R inhibitors. Eur J Med Chem. 2009 Apr;44(4):1788-93. | ||||
| REF 19 | Design and biological evaluation of novel triaryl pyrazoline derivatives with dioxane moiety for selective BRAF V600E inhibition. Eur J Med Chem. 2018 Jul 15;155:725-735. | ||||
| REF 20 | Pyridoimidazolones as novel potent inhibitors of v-Raf murine sarcoma viral oncogene homologue B1 (BRAF). J Med Chem. 2009 Apr 23;52(8):2255-64. | ||||
| REF 21 | Novel tricyclic pyrazole BRAF inhibitors with imidazole or furan central scaffolds. Bioorg Med Chem. 2010 Sep 15;18(18):6934-52. | ||||
| REF 22 | Potent BRAF kinase inhibitors based on 2,4,5-trisubstituted imidazole with naphthyl and benzothiophene 4-substituents. Bioorg Med Chem. 2013 Mar 1;21(5):1284-304. | ||||
| REF 23 | Natural Products as Sources of New Drugs from 1981 to 2014. J Nat Prod. 2016 Mar 25;79(3):629-61. | ||||
| REF 24 | N-Acetyl-3-aminopyrazoles block the non-canonical NF-kB cascade by selectively inhibiting NIK. Medchemcomm. 2018 Apr 12;9(6):963-968. | ||||
| REF 25 | Optimization of potent DFG-in inhibitors of platelet derived growth factor receptor (PDGF-R) guided by water thermodynamics. J Med Chem. 2015 Jan 8;58(1):170-82. | ||||
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