Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T01597 | Target Info | |||
| Target Name | Catalase (CAT) | ||||
| Synonyms | Human catalase | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | CAT | ||||
| Biochemical Class | Peroxide acceptor oxidoreductase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: NADPH | Ligand Info | |||||
| Structure Description | HUMAN ERYTHROCYTE CATALASE | PDB:1DGF | ||||
| Method | X-ray diffraction | Resolution | 1.50 Å | Mutation | No | [1] |
| PDB Sequence |
RDPASDQMQH
14 WKEQRAAQKA24 DVLTTGAGNP34 VGDKLNVITV44 GPRGPLLVQD54 VVFTDEMAHF 64 DRERIPERVV74 HAKGAGAFGY84 FEVTHDITKY94 SKAKVFEHIG104 KKTPIAVRFS 114 TVAGESGSAD124 TVRDPRGFAV134 KFYTEDGNWD144 LVGNNTPIFF154 IRDPILFPSF 164 IHSQKRNPQT174 HLKDPDMVWD184 FWSLRPESLH194 QVSFLFSDRG204 IPDGHRHMNG 214 YGSHTFKLVN224 ANGEAVYCKF234 HYKTDQGIKN244 LSVEDAARLS254 QEDPDYGIRD 264 LFNAIATGKY274 PSWTFYIQVM284 TFNQAETFPF294 NPFDLTKVWP304 HKDYPLIPVG 314 KLVLNRNPVN324 YFAEVEQIAF334 DPSNMPPGIE344 ASPDKMLQGR354 LFAYPDTHRH 364 RLGPNYLHIP374 VNCPYRARVA384 NYQRDGPMCM394 QDNQGGAPNY404 YPNSFGAPEQ 414 QPSALEHSIQ424 YSGEVRRFNT434 ANDDNVTQVR444 AFYVNVLNEE454 QRKRLCENIA 464 GHLKDAQIFI474 QKKAVKNFTE484 VHPDYGSHIQ494 ALLDKYN
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PRO151
3.570
HIS194
2.632
PHE198
3.370
SER201
3.067
ASP202
4.512
ARG203
2.829
ASN213
2.589
TYR215
4.270
HIS235
3.479
LYS237
2.721
ILE242
4.348
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: [Histidin-1-YL-4H-[1,2,4]triazol-5-YL]-amine | Ligand Info | |||||
| Structure Description | HUMAN ERYTHROCYTE CATALASE 3-AMINO-1,2,4-TRIAZOLE COMPLEX | PDB:1DGH | ||||
| Method | X-ray diffraction | Resolution | 2.00 Å | Mutation | Yes | [1] |
| PDB Sequence |
SRDPASDQMQ
13 HWKEQRAAQK23 ADVLTTGAGN33 PVGDKLNVIT43 VGPRGPLLVQ53 DVVFTDEMAH 63 FDRERIPERV73 VAKGAGAFGY84 FEVTHDITKY94 SKAKVFEHIG104 KKTPIAVRFS 114 TVAGESGSAD124 TVRDPRGFAV134 KFYTEDGNWD144 LVGNNTPIFF154 IRDPILFPSF 164 IHSQKRNPQT174 HLKDPDMVWD184 FWSLRPESLH194 QVSFLFSDRG204 IPDGHRHMNG 214 YGSHTFKLVN224 ANGEAVYCKF234 HYKTDQGIKN244 LSVEDAARLS254 QEDPDYGIRD 264 LFNAIATGKY274 PSWTFYIQVM284 TFNQAETFPF294 NPFDLTKVWP304 HKDYPLIPVG 314 KLVLNRNPVN324 YFAEVEQIAF334 DPSNMPPGIE344 ASPDKMLQGR354 LFAYPDTHRH 364 RLGPNYLHIP374 VNCPYRARVA384 NYQRDGPMCM394 QDNQGGAPNY404 YPNSFGAPEQ 414 QPSALEHSIQ424 YSGEVRRFNT434 ANDDNVTQVR444 AFYVNVLNEE454 QRKRLCENIA 464 GHLKDAQIFI474 QKKAVKNFTE484 VHPDYGSHIQ494 ALLDKYN
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Active and inhibited human catalase structures: ligand and NADPH binding and catalytic mechanism. J Mol Biol. 2000 Feb 11;296(1):295-309. | ||||
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