Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T01973 | Target Info | |||
| Target Name | Macrophage-stimulating protein receptor (RON) | ||||
| Synonyms | p185Ron; Proteintyrosine kinase 8; Macrophagestimulating protein receptor beta chain; Macrophagestimulating protein receptor; MST1R; MSP receptor; CDw136; CD136 | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | MST1R | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: AMP-PNP | Ligand Info | |||||
| Structure Description | RON in complex with ligand AMP-PNP | PDB:3PLS | ||||
| Method | X-ray diffraction | Resolution | 2.24 Å | Mutation | Yes | [1] |
| PDB Sequence |
RDLDSALLAE
1069 VKDVLIPHER1079 VVTHSDRVIG1089 KGHFGVVYHG1099 EYIDQAQNRI1109 QCAIKSLSRI 1119 TEMQQVEAFL1129 REGLLMRGLN1139 HPNVLALIGI1149 MLPPEGLPHV1159 LLPYMCHGDL 1169 LQFIRSPQRN1179 PTVKDLISFG1189 LQVARGMEYL1199 AEQKFVHRDL1209 AARNCMLDES 1219 FTVKVADFGL1229 ARDILDREYY1239 SVQQHRHARL1249 PVKWTALESL1259 QTYRFTTKSD 1269 VWSFGVLLWE1279 LLTRGAPPYR1289 HIDPFDLTHF1299 LAQGRRLPQP1309 EYCPDSLYQV 1319 MQQCWEADPA1329 VRPTFRVLVG1339 EVEQIVSALL1349 GDHYVQLP
|
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|
|
ILE1088
3.618
GLY1089
3.742
LYS1090
3.718
GLY1091
3.399
HIS1092
4.798
GLY1094
4.024
VAL1096
3.188
ALA1112
3.848
LYS1114
3.250
LEU1144
3.903
LEU1161
3.725
|
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | The crystal structure of a constitutively active mutant RON kinase suggests an intramolecular autophosphorylation hypothesis. Biochemistry. 2010 Sep 21;49(37):7972-4. | ||||
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