Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T02617 | Target Info | |||
| Target Name | Transferrin (TF) | ||||
| Synonyms | Siderophilin; Serotransferrin; PRO1400; Beta-1 metal-binding globulin | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | TF | ||||
| Biochemical Class | Transferrin | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Nitrilotriacetic acid | Ligand Info | |||||
| Structure Description | Bismuth bound human serum transferrin | PDB:4H0W | ||||
| Method | X-ray diffraction | Resolution | 2.40 Å | Mutation | No | [1] |
| PDB Sequence |
VPDKTVRWCA
10 VSEHEATKCQ20 SFRDHMKSVI30 PSDGPSVACV40 KKASYLDCIR50 AIAANEADAV 60 TLDAGLVYDA70 YLAPNNLKPV80 VAEFYGSKED90 PQTFYYAVAV100 VKKDSGFQMN 110 QLRGKKSCHT120 GLGRSAGWNI130 PIGLLYCDLP140 EPRKPLEKAV150 ANFFSGSCAP 160 CADGTDFPQL170 CQLCPGCGCS180 TLNQYFGYSG190 AFKCLKDGAG200 DVAFVKHSTI 210 FENLANKADR220 DQYELLCLDN230 TRKPVDEYKD240 CHLAQVPSHT250 VVARSMGGKE 260 DLIWELLNQA270 QEHFGKDKSK280 EFQLFSSPHG290 KDLLFKDSAH300 GFLKVPPRMD 310 AKMYLGYEYV320 TAIRNLREGT330 CPEAPTDECK340 PVKWCALSHH350 ERLKCDEWSV 360 NSVGKIECVS370 AETTEDCIAK380 IMNGEADAMS390 LDGGFVYIAG400 KCGLVPVLAE 410 NYNKSDNCED420 TPEAGYFAIA430 VVKKSASDLT440 WDNLKGKKSC450 HTAVGRTAGW 460 NIPMGLLYNK470 INHCRFDEFF480 SEGCAPGSKK490 DSSLCKLCMG500 SGLNLCEPNN 510 KEGYYGYTGA520 FRCLVEKGDV530 AFVKHQTVPQ540 NTGGKNPDPW550 AKNLNEKDYE 560 LLCLDGTRKP570 VEEYANCHLA580 RAPNHAVVTR590 KDKEACVHKI600 LRQQQHLFGS 610 NVTDCSGNFC620 LFRSETKDLL630 FRDDTVCLAK640 LHDRNTYEKY650 LGEEYVKAVG 660 NLRKCSTSSL670 LEACTFRRP
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: Pyrophosphate 2- | Ligand Info | |||||
| Structure Description | Crystal structure of human transferrin bound to Triferic FPC iron pyrophosphate | PDB:6CTC | ||||
| Method | X-ray diffraction | Resolution | 2.60 Å | Mutation | No | [2] |
| PDB Sequence |
DKTVRWCAVS
12 EHEATKCQSF22 RDHMKSVIPS32 DGPSVACVKK42 ASYLDCIRAI52 AANEADAVTL 62 DAGLVYDAYL72 APNNLKPVVA82 EFYGSKEDPQ92 TFYYAVAVVK102 KDSGFQMNQL 112 RGKKSCHTGL122 GRSAGWNIPI132 GLLYCDLPEP142 RKPLEKAVAN152 FFSGSCAPCA 162 DGTDFPQLCQ172 LCPGCGCSTL182 NQYFGYSGAF192 KCLKDGAGDV202 AFVKHSTIFE 212 NLANKADRDQ222 YELLCLDNTR232 KPVDEYKDCH242 LAQVPSHTVV252 ARSMGGKEDL 262 IWELLNQAQE272 HFGKDKSKEF282 QLFSSPHGKD292 LLFKDSAHGF302 LKVPPRMDAK 312 MYLGYEYVTA322 IRNLREGTCP332 EECKPVKWCA346 LSHHERLKCD356 EWSVNSVGKI 366 ECVSAETTED376 CIAKIMNGEA386 DAMSLDGGFV396 YIAGKCGLVP406 VLAENYNKSD 416 NCEDTPEAGY426 FAIAVVKKSA436 SDLTWDNLKG446 KKSCHTAVGR456 TAGWNIPMGL 466 LYNKINHCRF476 DEFFSEGCAP486 GSKKDSSLCK496 LCMGSGLNLC506 EPNNKEGYYG 516 YTGAFRCLVE526 KGDVAFVKHQ536 TVPQNTGGKN546 PDPWAKNLNE556 KDYELLCLDG 566 TRKPVEEYAN576 CHLARAPNHA586 VVTRKDKEAC596 VHKILRQQQH606 LFGSNVTDCS 616 GNFCLFRSET626 KDLLFRDDTV636 CLAKLHDRNT646 YEKYLGEEYV656 KAVGNLRKCS 666 TSSLLEACTF676 RRP
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| Ligand Name: N6-[(7-Azido-4-methyl-2-oxo-2H-1-benzopyran-3-yl)acetyl]-N2,N2-bis(carboxymethyl)-L-lysine | Ligand Info | |||||
| Structure Description | Human serum trnasferrin bound to a fluorescent probe | PDB:5Y6K | ||||
| Method | X-ray diffraction | Resolution | 2.86 Å | Mutation | No | [3] |
| PDB Sequence |
DKTVRWCAVS
12 EHEATKCQSF22 RDHMKSVIPS32 DGPSVACVKK42 ASYLDCIRAI52 AANEADAVTL 62 DAGLVYDAYL72 APNNLKPVVA82 EFYGSKEDPQ92 TFYYAVAVVK102 KDSGFQMNQL 112 RGKKSCHTGL122 GRSAGWNIPI132 GLLYCDLPEP142 RKPLEKAVAN152 FFSGSCAPCA 162 DGTDFPQLCQ172 LCPGCGCSTL182 NQYFGYSGAF192 KCLKDGAGDV202 AFVKHSTIFE 212 NLANKADRDQ222 YELLCLDNTR232 KPVDEYKDCH242 LAQVPSHTVV252 ARSMGGKEDL 262 IWELLNQAQE272 HFGKDKSKEF282 QLFSSPHGKD292 LLFKDSAHGF302 LKVPPRMDAK 312 MYLGYEYVTA322 IRNLREGTCP332 CKPVKWCALS348 HHERLKCDEW358 SVNSVGKIEC 368 VSAETTEDCI378 AKIMNGEADA388 MSLDGGFVYI398 AGKCGLVPVL408 AENYNAGYFA 428 IAVVKKSASD438 LTWDNLKGKK448 SCHTAVGRTA458 GWNIPMGLLY468 NKINHCRFDE 478 FFSEGCAPGS488 KKDSSLCKLC498 MGSGLNLCEP508 NNKEGYYGYT518 GAFRCLVEKG 528 DVAFVKHQTV538 PQNTGGKNPD548 PWAKNLNEKD558 YELLCLDGTR568 KPVEEYANCH 578 LARAPNHAVV588 TRKDKEACVH598 KILRQQQHLF608 GSNSETKDLL630 FRDDTVCLAK 640 LHDRNTYEKY650 LGEEYVKAVG660 NLRKCSTSSL670 LEACTFRRP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .8R6 or .8R62 or .8R63 or :38R6;style chemicals stick;color identity;select .A:63 or .A:95 or .A:123 or .A:124 or .A:125 or .A:188 or .A:206 or .A:248 or .A:292 or .A:296 or .A:602 or .A:603; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Iron and bismuth bound human serum transferrin reveals a partially-opened conformation in the N-lobe. Sci Rep. 2012;2:999. | ||||
| REF 2 | Ferric pyrophosphate citrate: interactions with transferrin. Biometals. 2018 Dec;31(6):1081-1089. | ||||
| REF 3 | Tracking iron-associated proteomes in pathogens by a fluorescence approach. Metallomics. 2018 Jan 24;10(1):77-82. | ||||
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