Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T03661 Target Info
Target Name Adenosine deaminase (ADA)
Synonyms Adenosine aminohydrolase; ADA1
Target Type Successful Target
Gene Name ADA
Biochemical Class Carbon-nitrogen hydrolase
UniProt ID
ADA_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Deoxyadenosine Ligand Info
Structure Description The crystal structure of human adenosine deaminase PDB:3IAR
Method X-ray diffraction Resolution 1.52 Å Mutation No [1]
PDB Sequence
PAFDKPKVEL
14
HVHLDGSIKP
24
ETILYYGRRR
34
GIALPANTAE
44
GLLNVIGMDK
54

PLTLPDFLAK
64
FDYYMPAIAG
74
CREAIKRIAY
84
EFVEMKAKEG
94
VVYVEVRYSP
104

HLLANSKVEP
114
IPWNQAEGDL
124
TPDEVVALVG
134
QGLQEGERDF
144
GVKARSILCC
154

MRHQPNWSPK
164
VVELCKKYQQ
174
QTVVAIDLAG
184
DETIPGSSLL
194
PGHVQAYQEA
204

VKSGIHRTVH
214
AGEVGSAEVV
224
KEAVDILKTE
234
RLGHGYHTLE
244
DQALYNRLRQ
254

ENMHFEICPW
264
SSYLTGAWKP
274
DTEHAVIRLK
284
NDQANYSLNT
294
DDPLIFKSTL
304

DTDYQMTKRD
314
MGFTEEEFKR
324
LNINAAKSSF
334
LPEDEKRELL
344
DLLYKAYGMP
354

PSASAGQNLA
364
Residue
Distance (Å)
HIS15
3.825
HIS17
2.813
ASP19
2.639
LEU58
4.267
PHE61
3.951
LEU62
3.628
PHE65
3.554
ARG101
4.177
TYR102
3.827
SER103
3.774
Residue
Distance (Å)
LEU106
3.587
CYS153
4.252
MET155
3.728
ALA183
3.708
GLY184
3.074
HIS214
3.093
GLU217
2.799
HIS238
2.945
ASP295
2.853
ASP296
2.800
References  Top
REF 1 The crystal structure of human adenosine deaminase

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