Binding Site Information of Target
Target General Information | Top | ||||
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Target ID | T10513 | Target Info | |||
Target Name | Integrin beta-2 (ITGB2) | ||||
Synonyms | MFI7; Integrin alpha-M/beta-2; Complement receptor C3 subunit beta; Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta; CD18 | ||||
Target Type | Clinical trial Target | ||||
Gene Name | ITGB2 | ||||
Biochemical Class | Integrin | ||||
UniProt ID |
Drug Binding Sites of Target | Top | |||||
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Ligand Name: 2-(Acetylamino)-2-Deoxy-a-D-Glucopyranose | Ligand Info | |||||
Structure Description | The crystal structure of the PSI/Hybrid domain/ I-EGF1 segment from the human integrin beta2 at 1.8 resolution | PDB:1YUK | ||||
Method | X-ray diffraction | Resolution | 1.80 Å | Mutation | No | [1] |
PDB Sequence |
> Chain A
QECTKFKVSS 10 CRECIESGPG20 CTWCQKLNFT30 GPGDPDSIRC40 DTRPQLLMRG50 CAADDIMDPT 60 SLAETQEQKQ75 LSPQKVTLYL85 RPGQAAAFNV95 TFRR> Chain B SRVFLDHNAL 352 PDTLKVTYDS362 FCSNGVTHRN372 QPRGDCDGVQ382 INVPITFQVK392 VTATECIQEQ 402 SFVIRALGFT412 DIVTVQVLPQ422 CECRCRDQSR432 DRSLCHGKGF442 LECGICRCDT 452 GYIGKNCEHH462
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References | Top | ||||
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REF 1 | The crystal structure of the plexin-semaphorin-integrin domain/hybrid domain/I-EGF1 segment from the human integrin beta2 subunit at 1.8-A resolution. J Biol Chem. 2005 Aug 26;280(34):30586-93. |
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