Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T10513 Target Info
Target Name Integrin beta-2 (ITGB2)
Synonyms MFI7; Integrin alpha-M/beta-2; Complement receptor C3 subunit beta; Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta; CD18
Target Type Clinical trial Target
Gene Name ITGB2
Biochemical Class Integrin
UniProt ID
ITB2_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: 2-(Acetylamino)-2-Deoxy-a-D-Glucopyranose Ligand Info
Structure Description The crystal structure of the PSI/Hybrid domain/ I-EGF1 segment from the human integrin beta2 at 1.8 resolution PDB:1YUK
Method X-ray diffraction Resolution 1.80 Å Mutation No [1]
PDB Sequence
> Chain A
QECTKFKVSS
10
CRECIESGPG
20
CTWCQKLNFT
30
GPGDPDSIRC
40
DTRPQLLMRG
50

CAADDIMDPT
60
SLAETQEQKQ
75
LSPQKVTLYL
85
RPGQAAAFNV
95
TFRR
> Chain B
SRVFLDHNAL
352
PDTLKVTYDS
362
FCSNGVTHRN
372
QPRGDCDGVQ
382
INVPITFQVK
392

VTATECIQEQ
402
SFVIRALGFT
412
DIVTVQVLPQ
422
CECRCRDQSR
432
DRSLCHGKGF
442

LECGICRCDT
452
GYIGKNCEHH
462
Residue
Distance (Å)
LEU27[A]
3.868
ASN28[A]
2.630
ASN94[A]
2.708
ASN458[B]
3.774
Residue
Distance (Å)
PHE363[B]
3.149
THR388[B]
4.563
GLN390[B]
2.678
References  Top
REF 1 The crystal structure of the plexin-semaphorin-integrin domain/hybrid domain/I-EGF1 segment from the human integrin beta2 subunit at 1.8-A resolution. J Biol Chem. 2005 Aug 26;280(34):30586-93.

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