Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T13017 Target Info
Target Name Syndecan-1 (SDC1)
Synonyms SYND1; SDC; CD138
Target Type Clinical trial Target
Gene Name SDC1
Biochemical Class Peptide translocating syndecan
UniProt ID
SDC1_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Phosphonotyrosine Ligand Info
Structure Description Crystal Structure of T-cell Lymphoma Invasion and Metastasis-1 PDZ in complex with phosphorylated Syndecan1 Peptide PDB:4GVC
Method X-ray diffraction Resolution 1.54 Å Mutation No [1]
PDB Sequence
TKQEEFA
Residue
Distance (Å)
GLU5
4.530
PHE6
1.333
Residue
Distance (Å)
ALA8
1.325
Ligand Name: 5-(Dimethylamino)naphthalene-1-sulfonic acid Ligand Info
Structure Description Crystal Structure of T-cell Lymphoma Invasion and Metastasis-1 PDZ in complex with phosphorylated Syndecan1 Peptide PDB:4GVC
Method X-ray diffraction Resolution 1.54 Å Mutation No [1]
PDB Sequence
TKQEEFA
Residue
Distance (Å)
THR1
1.769
Residue
Distance (Å)
LYS2
3.873
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References  Top
REF 1 The structure of the Tiam1 PDZ domain/ phospho-syndecan1 complex reveals a ligand conformation that modulates protein dynamics. Structure. 2013 Mar 5;21(3):342-54.

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