Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T14030 Target Info
Target Name Ras-related protein Rab-7a (RAB7A)
Synonyms RAB7
Target Type Literature-reported Target
Gene Name RAB7A
Biochemical Class Small GTPase
UniProt ID
RAB7A_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Guanosine-5'-Triphosphate Ligand Info
Structure Description crystal structure of human small GTPase Rab7(GTP) PDB:1T91
Method X-ray diffraction Resolution 1.90 Å Mutation Yes [1]
PDB Sequence
VLLKVIILGD
16
SGVGKTSLMN
26
QYVNKKFSNQ
36
YKATIGADFL
46
TKEVMVDDRL
56

VTMQIWDTAG
66
LERFQSLGVA
76
FYRGADCCVL
86
VFDVTAPNTF
96
KTLDSWRDEF
106

LIQASPRDPE
116
NFPFVVLGNK
126
IDLENRQVAT
136
KRAQAWCYSK
146
NNIPYFETSA
156

KEAINVEQAF
166
QTIARNALKQ
176
ETEVEL
Residue
Distance (Å)
GLY15
4.708
ASP16
3.717
SER17
2.777
GLY18
2.883
VAL19
3.450
GLY20
3.103
LYS21
2.748
THR22
2.952
SER23
2.945
PHE33
3.543
SER34
3.737
ASN35
3.484
GLN36
4.936
TYR37
2.593
LYS38
4.214
Residue
Distance (Å)
ALA39
3.917
THR40
2.877
ASP63
4.833
THR64
4.153
ALA65
3.947
GLY66
2.774
LEU67
4.233
ASN125
3.398
LYS126
2.529
ASP128
2.754
LEU129
2.971
SER155
3.299
ALA156
2.549
LYS157
2.853
GLU158
4.898
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Ligand Name: Phosphoaminophosphonic acid-guanylate ester Ligand Info
Structure Description Structure of GTP-bound L129F mutant Rab7 PDB:3LAW
Method X-ray diffraction Resolution 2.80 Å Mutation Yes [2]
PDB Sequence
KVLLKVIILG
15
DSGVGKTSLM
25
NQYVNKKFSN
35
QYKATIGADF
45
LTKEVMVDDR
55

LVTMQIWDTA
65
GQERFQSLGV
75
AFYRGADCCV
85
LVFDVTAPNT
95
FKTLDSWRDE
105

FLIQASPRDP
115
ENFPFVVLGN
125
KIDFENRQVA
135
TKRAQAWCYS
145
KNNIPYFETS
155

AKEAINVEQA
165
FQTIARNALK
175
QETEVEL
Residue
Distance (Å)
ASP16
3.437
SER17
3.128
GLY18
3.268
VAL19
3.231
GLY20
2.907
LYS21
2.753
THR22
2.616
SER23
2.683
PHE33
3.695
SER34
2.917
ASN35
3.025
GLN36
4.773
TYR37
3.359
LYS38
4.584
ALA39
3.981
Residue
Distance (Å)
THR40
2.467
ASP63
4.800
THR64
3.975
ALA65
4.176
GLY66
3.167
GLN67
4.721
ASN125
3.142
LYS126
3.055
ASP128
2.710
PHE129
3.241
THR154
4.854
SER155
3.524
ALA156
2.910
LYS157
3.486
References  Top
REF 1 Structural basis for recruitment of RILP by small GTPase Rab7. EMBO J. 2005 Apr 20;24(8):1491-501.
REF 2 Disease mutations in Rab7 result in unregulated nucleotide exchange and inappropriate activation. Hum Mol Genet. 2010 Mar 15;19(6):1033-47.

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