Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T16285 Target Info
Target Name Tracheobronchial mucin 5A (MUC5AC)
Synonyms Tracheobronchial mucin; TBM; Mucin5AC; Mucin5 subtype AC, tracheobronchial; Mucin-5AC; Mucin-5 subtype AC, tracheobronchial; Major airway glycoprotein; MUC5; MUC-5AC; Lewis B blood group antigen; LeB; Gastric mucin
Target Type Literature-reported Target
Gene Name MUC5AC
UniProt ID
MUC5A_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Uridine-5'-Diphosphate Ligand Info
Structure Description Crystal structure of the active form of GalNAc-T2 in complex with UDP and the glycopeptide MUC5AC-13 PDB:5AJP
Method X-ray diffraction Resolution 1.65 Å Mutation Yes [1]
PDB Sequence
TTPSPVPTTS
11
TTSAA
Residue
Distance (Å)
PRO4
3.233
Residue
Distance (Å)
SER5
2.676
Ligand Name: N-Acetyl-2-deoxy-2-amino-galactose Ligand Info
Structure Description Crystal structure of the inactive form of GalNAc-T2 in complex with the glycopeptide MUC5AC-3,13 PDB:5AJO
Method X-ray diffraction Resolution 1.48 Å Mutation Yes [1]
PDB Sequence
AGTTPSPVPT
9
TSTTSAA
Residue
Distance (Å)
THR2
3.814
THR3
1.421
PRO4
3.595
SER5
2.537
PRO6
3.908
Residue
Distance (Å)
SER11
3.122
THR13
1.409
SER14
3.543
ALA15
3.395
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References  Top
REF 1 Dynamic interplay between catalytic and lectin domains of GalNAc-transferases modulates protein O-glycosylation. Nat Commun. 2015 May 5;6:6937.

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