Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T17427 | Target Info | |||
| Target Name | Platelet glycoprotein Ib alpha (CD42b) | ||||
| Synonyms | Platelet glycoprotein Ib alpha chain; Glycoprotein Ibalpha; Glycocalicin; GPIbalpha; GPIbA; GPIb-alpha; GPIb alpha; GP-Ib alpha; Antigen CD42balpha; Antigen CD42b-alpha | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | GP1BA | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: tyrosine O-sulfate | Ligand Info | |||||
| Structure Description | CRYSTAL STRUCTURE OF THE COMPLEX OF PLATELET RECEPTOR GPIB-ALPHA AND ALPHA-THROMBIN AT 2.6A | PDB:1P8V | ||||
| Method | X-ray diffraction | Resolution | 2.60 Å | Mutation | Yes | [1] |
| PDB Sequence |
HPICEVSKVA
10 SHLEVNCDKR20 DLTALPPDLP30 KDTTILHLSE40 NLLYTFSLAT50 LMPYTRLTQL 60 NLDRCELTKL70 QVDGTLPVLG80 TLDLSHNQLQ90 SLPLLGQTLP100 ALTVLDVSFN 110 RLTSLPLGAL120 RGLGELQELY130 LKGNELKTLP140 PGLLTPTPKL150 EKLSLANNNL 160 TELPAGLLNG170 LENLDTLLLQ180 ENSLYTIPKG190 FFGSHLLPFA200 FLHGNPWLCN 210 CEILYFRRWL220 QDNAENVYVW230 KQGVDVKAMT240 SNVASVQCDN250 SDKFPVYKYP 260 GKGCPTLGDE270 GDTDLDY
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Crystal structure of the GpIbalpha-thrombin complex essential for platelet aggregation. Science. 2003 Jul 11;301(5630):222-6. | ||||
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