Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T21678 | Target Info | |||
| Target Name | Alpha-galactosidase A (GLA) | ||||
| Synonyms | Melibiase; INN=Agalsidase; Alpha-D-galactoside galactohydrolase; Alpha-D-galactosidase A | ||||
| Target Type | Successful Target | ||||
| Gene Name | GLA | ||||
| Biochemical Class | Glycosylase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Levovist | Ligand Info | |||||
| Structure Description | Pharmacological Chaperoning in Human alpha-Galactosidase | PDB:3S5Z | ||||
| Method | X-ray diffraction | Resolution | 2.00 Å | Mutation | No | [1] |
| PDB Sequence |
LDNGLARTPT
41 MGWLHWERFM51 CNLDCQEEPD61 SCISEKLFME71 MAELMVSEGW81 KDAGYEYLCI 91 DDCWMAPQRD101 SEGRLQADPQ111 RFPHGIRQLA121 NYVHSKGLKL131 GIYADVGNKT 141 CAGFPGSFGY151 YDIDAQTFAD161 WGVDLLKFDG171 CYCDSLENLA181 DGYKHMSLAL 191 NRTGRSIVYS201 CEWPLYMWPF211 QKPNYTEIRQ221 YCNHWRNFAD231 IDDSWKSIKS 241 ILDWTSFNQE251 RIVDVAGPGG261 WNDPDMLVIG271 NFGLSWNQQV281 TQMALWAIMA 291 APLFMSNDLR301 HISPQAKALL311 QDKDVIAINQ321 DPLGKQGYQL331 RQGDNFEVWE 341 RPLSGLAWAV351 AMINRQEIGG361 PRSYTIAVAS371 LGKGVACNPA381 CFITQLLPVK 391 RKLGFYEWTS401 RLRSHINPTG411 TVLLQLENTM421
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: Migalastat | Ligand Info | |||||
| Structure Description | Pharmacological Chaperoning in Human alpha-Galactosidase | PDB:3S5Y | ||||
| Method | X-ray diffraction | Resolution | 2.10 Å | Mutation | No | [1] |
| PDB Sequence |
LDNGLARTPT
41 MGWLHWERFM51 CNLDCQEEPD61 SCISEKLFME71 MAELMVSEGW81 KDAGYEYLCI 91 DDCWMAPQRD101 SEGRLQADPQ111 RFPHGIRQLA121 NYVHSKGLKL131 GIYADVGNKT 141 CAGFPGSFGY151 YDIDAQTFAD161 WGVDLLKFDG171 CYCDSLENLA181 DGYKHMSLAL 191 NRTGRSIVYS201 CEWPLYMWPF211 QKPNYTEIRQ221 YCNHWRNFAD231 IDDSWKSIKS 241 ILDWTSFNQE251 RIVDVAGPGG261 WNDPDMLVIG271 NFGLSWNQQV281 TQMALWAIMA 291 APLFMSNDLR301 HISPQAKALL311 QDKDVIAINQ321 DPLGKQGYQL331 RQGDNFEVWE 341 RPLSGLAWAV351 AMINRQEIGG361 PRSYTIAVAS371 LGKGVACNPA381 CFITQLLPVK 391 RKLGFYEWTS401 RLRSHINPTG411 TVLLQLENTM421
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: Deoxynojirimycin | Ligand Info | |||||
| Structure Description | Crystal structure of alpha-galactosidase A at pH 4.5 complexed with 1-deoxygalactonijirimycin | PDB:3GXT | ||||
| Method | X-ray diffraction | Resolution | 2.70 Å | Mutation | No | [2] |
| PDB Sequence |
LDNGLARTPT
41 MGWLHWERFM51 CNLDCQEEPD61 SCISEKLFME71 MAELMVSEGW81 KDAGYEYLCI 91 DDCWMAPQRD101 SEGRLQADPQ111 RFPHGIRQLA121 NYVHSKGLKL131 GIYADVGNKT 141 CAGFPGSFGY151 YDIDAQTFAD161 WGVDLLKFDG171 CYCDSLENLA181 DGYKHMSLAL 191 NRTGRSIVYS201 CEWPLYMWPF211 QKPNYTEIRQ221 YCNHWRNFAD231 IDDSWKSIKS 241 ILDWTSFNQE251 RIVDVAGPGG261 WNDPDMLVIG271 NFGLSWNQQV281 TQMALWAIMA 291 APLFMSNDLR301 HISPQAKALL311 QDKDVIAINQ321 DPLGKQGYQL331 RQGDNFEVWE 341 RPLSGLAWAV351 AMINRQEIGG361 PRSYTIAVAS371 LGKGVACNPA381 CFITQLLPVK 391 RKLGFYEWTS401 RLRSHINPTG411 TVLLQLENTM421
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .NOJ or .NOJ2 or .NOJ3 or :3NOJ;style chemicals stick;color identity;select .A:47 or .A:92 or .A:93 or .A:134 or .A:142 or .A:143 or .A:168 or .A:170 or .A:203 or .A:206 or .A:207 or .A:227 or .A:231 or .A:266 or .A:267; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: N-Acetyl-2-deoxy-2-amino-galactose | Ligand Info | |||||
| Structure Description | Interconversion of Human Lysosomal Enzyme Specificities | PDB:3LX9 | ||||
| Method | X-ray diffraction | Resolution | 2.04 Å | Mutation | Yes | [3] |
| PDB Sequence |
LDNGLARTPT
41 MGWLHWERFM51 CNLDCQEEPD61 SCISEKLFME71 MAELMVSEGW81 KDAGYEYLCI 91 DDCWMAPQRD101 SEGRLQADPQ111 RFPHGIRQLA121 NYVHSKGLKL131 GIYADVGNKT 141 CAGFPGSFGY151 YDIDAQTFAD161 WGVDLLKFDG171 CYCDSLENLA181 DGYKHMSLAL 191 NRTGRSIVYS201 CSWPAYMWPF211 QKPNYTEIRQ221 YCNHWRNFAD231 IDDSWKSIKS 241 ILDWTSFNQE251 RIVDVAGPGG261 WNDPDMLVIG271 NFGLSWNQQV281 TQMALWAIMA 291 APLFMSNDLR301 HISPQAKALL311 QDKDVIAINQ321 DPLGKQGYQL331 RQGDNFEVWE 341 RPLSGLAWAV351 AMINRQEIGG361 PRSYTIAVAS371 LGKGVACNPA381 CFITQLLPVK 391 RKLGFYEWTS401 RLRSHINPTG411 TVLLQLENTM421 Q
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .A2G or .A2G2 or .A2G3 or :3A2G;style chemicals stick;color identity;select .A:47 or .A:92 or .A:93 or .A:134 or .A:142 or .A:143 or .A:168 or .A:170 or .A:172 or .A:203 or .A:206 or .A:207 or .A:227 or .A:229 or .A:231 or .A:266 or .A:267; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: (3~{a}~{R},4~{S},5~{S},6~{S},7~{R},7~{a}~{S})-7-(hydroxymethyl)-2,2-bis(oxidanylidene)-3~{a},4,5,6,7,7~{a}-hexahydro-3~{H}-benzo[d][1,2,3]oxathiazole-4,5,6-triol | Ligand Info | |||||
| Structure Description | Crystal structure of human alpha-galactosidase A in complex with alpha-galactose configured cyclosulfamidate ME763 | PDB:6IBK | ||||
| Method | X-ray diffraction | Resolution | 1.99 Å | Mutation | No | [4] |
| PDB Sequence |
LDNGLARTPT
41 MGWLHWERFM51 CNLDCQEEPD61 SCISEKLFME71 MAELMVSEGW81 KDAGYEYLCI 91 DDCWMAPQRD101 SEGRLQADPQ111 RFPHGIRQLA121 NYVHSKGLKL131 GIYADVGNKT 141 CAGFPGSFGY151 YDIDAQTFAD161 WGVDLLKFDG171 CYCDSLENLA181 DGYKHMSLAL 191 NRTGRSIVYS201 CEWPLYMWPF211 QKPNYTEIRQ221 YCNHWRNFAD231 IDDSWKSIKS 241 ILDWTSFNQE251 RIVDVAGPGG261 WNDPDMLVIG271 NFGLSWNQQV281 TQMALWAIMA 291 APLFMSNDLR301 HISPQAKALL311 QDKDVIAINQ321 DPLGKQGYQL331 RQGDNFEVWE 341 RPLSGLAWAV351 AMINRQEIGG361 PRSYTIAVAS371 LGKGVACNPA381 CFITQLLPVK 391 RKLGFYEWTS401 RLRSHINPTG411 TVLLQLENTM421
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .YTW or .YTW2 or .YTW3 or :3YTW;style chemicals stick;color identity;select .A:47 or .A:92 or .A:93 or .A:134 or .A:142 or .A:143 or .A:168 or .A:170 or .A:172 or .A:203 or .A:206 or .A:207 or .A:227 or .A:231 or .A:266 or .A:267; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: beta-D-galactose | Ligand Info | |||||
| Structure Description | Pharmacological Chaperoning in Human alpha-Galactosidase | PDB:3S5Z | ||||
| Method | X-ray diffraction | Resolution | 2.00 Å | Mutation | No | [1] |
| PDB Sequence |
LDNGLARTPT
41 MGWLHWERFM51 CNLDCQEEPD61 SCISEKLFME71 MAELMVSEGW81 KDAGYEYLCI 91 DDCWMAPQRD101 SEGRLQADPQ111 RFPHGIRQLA121 NYVHSKGLKL131 GIYADVGNKT 141 CAGFPGSFGY151 YDIDAQTFAD161 WGVDLLKFDG171 CYCDSLENLA181 DGYKHMSLAL 191 NRTGRSIVYS201 CEWPLYMWPF211 QKPNYTEIRQ221 YCNHWRNFAD231 IDDSWKSIKS 241 ILDWTSFNQE251 RIVDVAGPGG261 WNDPDMLVIG271 NFGLSWNQQV281 TQMALWAIMA 291 APLFMSNDLR301 HISPQAKALL311 QDKDVIAINQ321 DPLGKQGYQL331 RQGDNFEVWE 341 RPLSGLAWAV351 AMINRQEIGG361 PRSYTIAVAS371 LGKGVACNPA381 CFITQLLPVK 391 RKLGFYEWTS401 RLRSHINPTG411 TVLLQLENTM421
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GAL or .GAL2 or .GAL3 or :3GAL;style chemicals stick;color identity;select .A:250 or .A:251 or .A:254 or .A:255 or .A:329 or .A:330 or .A:374; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: (1beta,6beta)-5beta-(Hydroxymethyl)-7-oxabicyclo[4.1.0]heptane-2alpha,3beta,4beta-triol | Ligand Info | |||||
| Structure Description | Crystal structure of human alpha-galactosidase A in complex with alpha-galactose configured cyclophellitol epoxide LWA481 | PDB:6IBR | ||||
| Method | X-ray diffraction | Resolution | 2.02 Å | Mutation | No | [4] |
| PDB Sequence |
LDNGLARTPT
41 MGWLHWERFM51 CNLDCQEEPD61 SCISEKLFME71 MAELMVSEGW81 KDAGYEYLCI 91 DDCWMAPQRD101 SEGRLQADPQ111 RFPHGIRQLA121 NYVHSKGLKL131 GIYADVGNKT 141 CAGFPGSFGY151 YDIDAQTFAD161 WGVDLLKFDG171 CYCDSLENLA181 DGYKHMSLAL 191 NRTGRSIVYS201 CEWPLYMWPF211 QKPNYTEIRQ221 YCNHWRNFAD231 IDDSWKSIKS 241 ILDWTSFNQE251 RIVDVAGPGG261 WNDPDMLVIG271 NFGLSWNQQV281 TQMALWAIMA 291 APLFMSNDLR301 HISPQAKALL311 QDKDVIAINQ321 DPLGKQGYQL331 RQGDNFEVWE 341 RPLSGLAWAV351 AMINRQEIGG361 PRSYTIAVAS371 LGKGVACNPA381 CFITQLLPVK 391 RKLGFYEWTS401 RLRSHINPTG411 TVLLQLENTM421
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .HBE or .HBE2 or .HBE3 or :3HBE;style chemicals stick;color identity;select .A:47 or .A:92 or .A:93 or .A:134 or .A:142 or .A:143 or .A:168 or .A:170 or .A:203 or .A:206 or .A:207 or .A:227 or .A:231 or .A:266 or .A:267; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: (1S,2S,3S,4S,5R,6S)-5-(hydroxymethyl)-7-azabicyclo[4.1.0]heptane-2,3,4-triol | Ligand Info | |||||
| Structure Description | Crystal structure of human alpha-galactosidase A in complex with alpha-galactose configured cyclophellitol aziridine ME737 | PDB:6IBT | ||||
| Method | X-ray diffraction | Resolution | 2.04 Å | Mutation | No | [4] |
| PDB Sequence |
LDNGLARTPT
41 MGWLHWERFM51 CNLDCQEEPD61 SCISEKLFME71 MAELMVSEGW81 KDAGYEYLCI 91 DDCWMAPQRD101 SEGRLQADPQ111 RFPHGIRQLA121 NYVHSKGLKL131 GIYADVGNKT 141 CAGFPGSFGY151 YDIDAQTFAD161 WGVDLLKFDG171 CYCDSLENLA181 DGYKHMSLAL 191 NRTGRSIVYS201 CEWPLYMWPF211 QKPNYTEIRQ221 YCNHWRNFAD231 IDDSWKSIKS 241 ILDWTSFNQE251 RIVDVAGPGG261 WNDPDMLVIG271 NFGLSWNQQV281 TQMALWAIMA 291 APLFMSNDLR301 HISPQAKALL311 QDKDVIAINQ321 DPLGKQGYQL331 RQGDNFEVWE 341 RPLSGLAWAV351 AMINRQEIGG361 PRSYTIAVAS371 LGKGVACNPA381 CFITQLLPVK 391 RKLGFYEWTS401 RLRSHINPTG411 TVLLQLENTM421
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .H9T or .H9T2 or .H9T3 or :3H9T;style chemicals stick;color identity;select .A:47 or .A:92 or .A:93 or .A:134 or .A:142 or .A:143 or .A:168 or .A:170 or .A:203 or .A:206 or .A:207 or .A:227 or .A:231 or .A:266 or .A:267; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: [(1~{S},2~{R},3~{S},4~{S},5~{R},6~{S})-2-(hydroxymethyl)-3,4,5,6-tetrakis(oxidanyl)cyclohexyl] hydrogen sulfate | Ligand Info | |||||
| Structure Description | Crystal structure of human alpha-galactosidase A in complex with alpha-galactose configured cyclosulfate ME776 | PDB:6IBM | ||||
| Method | X-ray diffraction | Resolution | 2.07 Å | Mutation | No | [4] |
| PDB Sequence |
LDNGLARTPT
41 MGWLHWERFM51 CNLDCQEEPD61 SCISEKLFME71 MAELMVSEGW81 KDAGYEYLCI 91 DDCWMAPQRD101 SEGRLQADPQ111 RFPHGIRQLA121 NYVHSKGLKL131 GIYADVGNKT 141 CAGFPGSFGY151 YDIDAQTFAD161 WGVDLLKFDG171 CYCDSLENLA181 DGYKHMSLAL 191 NRTGRSIVYS201 CEWPLYMWPF211 QKPNYTEIRQ221 YCNHWRNFAD231 IDDSWKSIKS 241 ILDWTSFNQE251 RIVDVAGPGG261 WNDPDMLVIG271 NFGLSWNQQV281 TQMALWAIMA 291 APLFMSNDLR301 HISPQAKALL311 QDKDVIAINQ321 DPLGKQGYQL331 RQGDNFEVWE 341 RPLSGLAWAV351 AMINRQEIGG361 PRSYTIAVAS371 LGKGVACNPA381 CFITQLLPVK 391 RKLGFYEWTS401 RLRSHINPTG411 TVLLQLENTM421
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .HF8 or .HF82 or .HF83 or :3HF8;style chemicals stick;color identity;select .A:47 or .A:92 or .A:93 or .A:134 or .A:142 or .A:143 or .A:168 or .A:170 or .A:172 or .A:203 or .A:206 or .A:207 or .A:227 or .A:231 or .A:266 or .A:267; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: Tris(hydroxyethyl)aminomethane | Ligand Info | |||||
| Structure Description | Crystal structure of acid-alpha-galactosidase A complexed with galactose at pH 4.5 | PDB:3GXP | ||||
| Method | X-ray diffraction | Resolution | 2.20 Å | Mutation | No | [2] |
| PDB Sequence |
LDNGLARTPT
41 MGWLHWERFM51 CNLDCQEEPD61 SCISEKLFME71 MAELMVSEGW81 KDAGYEYLCI 91 DDCWMAPQRD101 SEGRLQADPQ111 RFPHGIRQLA121 NYVHSKGLKL131 GIYADVGNKT 141 CAGFPGSFGY151 YDIDAQTFAD161 WGVDLLKFDG171 CYCDSLENLA181 DGYKHMSLAL 191 NRTGRSIVYS201 CEWPLYMWPF211 QKPNYTEIRQ221 YCNHWRNFAD231 IDDSWKSIKS 241 ILDWTSFNQE251 RIVDVAGPGG261 WNDPDMLVIG271 NFGLSWNQQV281 TQMALWAIMA 291 APLFMSNDLR301 HISPQAKALL311 QDKDVIAINQ321 DPLGKQGYQL331 RQGDNFEVWE 341 RPLSGLAWAV351 AMINRQEIGG361 PRSYTIAVAS371 LGKGVACNPA381 CFITQLLPVK 391 RKLGFYEWTS401 RLRSHINPTG411 TVLLQLENTM421
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .TAM or .TAM2 or .TAM3 or :3TAM;style chemicals stick;color identity;select .A:234 or .A:235 or .A:236 or .A:237 or .A:238 or .A:240 or .A:274 or .A:275 or .A:279 or .A:358; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 2-Deoxy-2,2-Difluoro-Beta-D-Lyxo-Hexopyranose | Ligand Info | |||||
| Structure Description | Human alpha-galactosidase catalytic mechanism 3. Covalent intermediate | PDB:3HG4 | ||||
| Method | X-ray diffraction | Resolution | 2.30 Å | Mutation | No | [5] |
| PDB Sequence |
LDNGLARTPT
41 MGWLHWERFM51 CNLDCQEEPD61 SCISEKLFME71 MAELMVSEGW81 KDAGYEYLCI 91 DDCWMAPQRD101 SEGRLQADPQ111 RFPHGIRQLA121 NYVHSKGLKL131 GIYADVGNKT 141 CAGFPGSFGY151 YDIDAQTFAD161 WGVDLLKFDG171 CYCDSLENLA181 DGYKHMSLAL 191 NRTGRSIVYS201 CEWPLYMWPF211 QKPNYTEIRQ221 YCNHWRNFAD231 IDDSWKSIKS 241 ILDWTSFNQE251 RIVDVAGPGG261 WNDPDMLVIG271 NFGLSWNQQV281 TQMALWAIMA 291 APLFMSNDLR301 HISPQAKALL311 QDKDVIAINQ321 DPLGKQGYQL331 RQGDNFEVWE 341 RPLSGLAWAV351 AMINRQEIGG361 PRSYTIAVAS371 LGKGVACNPA381 CFITQLLPVK 391 RKLGFYEWTS401 RLRSHINPTG411 TVLLQLENTM421
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .7JZ or .7JZ2 or .7JZ3 or :37JZ;style chemicals stick;color identity;select .A:47 or .A:92 or .A:93 or .A:134 or .A:142 or .A:143 or .A:168 or .A:170 or .A:172 or .A:203 or .A:206 or .A:207 or .A:227 or .A:231 or .A:266 or .A:267; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: (2r,3s,4r,5s)-N-(4-Fluorophenyl)-3,4,5-Trihydroxy-2-(Hydroxymethyl)piperidine-1-Carbothioamide | Ligand Info | |||||
| Structure Description | Crystal structure of human alpha-galactosidase A in complex with 1-deoxygalactonojirimycin-pFPhT | PDB:4NXS | ||||
| Method | X-ray diffraction | Resolution | 2.55 Å | Mutation | No | [6] |
| PDB Sequence |
LDNGLARTPT
41 MGWLHWERFM51 CNLDCQEEPD61 SCISEKLFME71 MAELMVSEGW81 KDAGYEYLCI 91 DDCWMAPQRD101 SEGRLQADPQ111 RFPHGIRQLA121 NYVHSKGLKL131 GIYADVGNKT 141 CAGFPGSFGY151 YDIDAQTFAD161 WGVDLLKFDG171 CYCDSLENLA181 DGYKHMSLAL 191 NRTGRSIVYS201 CEWPLYMWPF211 QKPNYTEIRQ221 YCNHWRNFAD231 IDDSWKSIKS 241 ILDWTSFNQE251 RIVDVAGPGG261 WNDPDMLVIG271 NFGLSWNQQV281 TQMALWAIMA 291 APLFMSNDLR301 HISPQAKALL311 QDKDVIAINQ321 DPLGKQGYQL331 RQGDNFEVWE 341 RPLSGLAWAV351 AMINRQEIGG361 PRSYTIAVAS371 LGKGVACNPA381 CFITQLLPVK 391 RKLGFYEWTS401 RLRSHINPTG411 TVLLQLENTM421
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .2OZ or .2OZ2 or .2OZ3 or :32OZ;style chemicals stick;color identity;select .A:47 or .A:92 or .A:93 or .A:134 or .A:142 or .A:143 or .A:168 or .A:170 or .A:172 or .A:203 or .A:206 or .A:207 or .A:227 or .A:230 or .A:231 or .A:266 or .A:267; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | The molecular basis of pharmacological chaperoning in human Alpha-galactosidase. Chem Biol. 2011 Dec 23;18(12):1521-6. | ||||
| REF 2 | Effects of pH and iminosugar pharmacological chaperones on lysosomal glycosidase structure and stability. Biochemistry. 2009 Jun 9;48(22):4816-27. | ||||
| REF 3 | Interconversion of the specificities of human lysosomal enzymes associated with Fabry and Schindler diseases. J Biol Chem. 2010 Jul 9;285(28):21560-6. | ||||
| REF 4 | Alpha-d-Gal-cyclophellitol cyclosulfamidate is a Michaelis complex analog that stabilizes therapeutic lysosomal alpha-galactosidase A in Fabry disease. doi:10.1039/C9SC03342D. | ||||
| REF 5 | Catalytic mechanism of human alpha-galactosidase. J Biol Chem. 2010 Feb 5;285(6):3625-3632. | ||||
| REF 6 | Molecular basis of 1-deoxygalactonojirimycin arylthiourea binding to human Alpha-galactosidase a: pharmacological chaperoning efficacy on Fabry disease mutants. ACS Chem Biol. 2014 Jul 18;9(7):1460-9. | ||||
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