Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T23000 Target Info
Target Name Gelsolin (GSN)
Synonyms GSN; Brevin; Actindepolymerizing factor; AGEL
Target Type Literature-reported Target
Gene Name GSN
UniProt ID
GELS_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: 2-(2-Methoxyethoxy)ethanol Ligand Info
Structure Description HUMAN GELSOLIN FROM RESIDUES GLU28 TO ARG161 WITH CALCIUM PDB:5ZZ0
Method X-ray diffraction Resolution 2.63 Å Mutation No [1]
PDB Sequence
HPEFLKAGKE
38
PGLQIWRVEK
48
FDLVPVPTNL
58
YGDFFTGDAY
68
VILKTVQLRN
78

GNLQYDLHYW
88
LGNECSQDES
98
GAAAIFTVQL
108
DDYLNGRAVQ
118
HREVQGFESA
128

TFLGYFKSGL
138
KYKKGGVASG
148
FK
Residue
Distance (Å)
GLN82
3.224
TYR83
3.876
Residue
Distance (Å)
ASP84
3.650
VAL117
3.164
References  Top
REF 1 Bonsai Gelsolin Survives Heat Induced Denaturation by Forming beta-Amyloids which Leach Out Functional Monomer. Sci Rep. 2018 Aug 22;8(1):12602.

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